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Your search keyword '"Margolick, J.B."' showing total 22 results
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22 results on '"Margolick, J.B."'

1. Majority of the latent reservoir resides in CD32a negative CD4+ T cells

Author

Bertagnolli, L.N., primary, White, J.A., additional, Beg, S.A., additional, Simonetti, F.R., additional, Lai, J., additional, Tomescu, C., additional, Murray, A.J., additional, Antar, Annukka A.R., additional, Zhang, H.a.o., additional, Margolick, J.B., additional, Montaner, L.J., additional, Siliciano, R.F., additional, Laird, G.M., additional, and Siliciano, J.D., additional

Published
2017
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3. Antiretroviral therapy and the prevalence and incidence of diabetes [2] (multiple letters)

Author

Brown, T.T., Margolick, J.B., Kingsley, L.A., Li, X., Riddler, S.A., Cole, S.R., Visscher, B.R., Palella, F.J., and Dobs, A.S.

Abstract

In the study by Brown et al,1 the authors did not mention several limitations that might have an important impact on the interpretation of the results. First, the study only included men, who were mostly white (approximately 86%). Therefore, the results cannot be extrapolated to women and other ethnic groups. Second, the family history of diabetes was not ascertained in the study participants, and this could have confounded the magnitude of differences in prevalence and incidence of diabetes between the 2 study groups. Third, the reported prevalence and incidence rates of diabetes were likely to be overestimated because the diagnosis of diabetes was not confirmed by a repeated measurement of fasting plasma glucose.

Published
2005
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6. Common genetic variation and the control of HIV-1 in humans

Author

Fellay, J., Ge, D., Shianna, K.V., Colombo, S., Ledergerber, B., Cirulli, E.T., Urban, T.J., Zhang, K., Gumbs, C.E., Smith, J. P., Castagna, A., Cozzi-Lepri, A., De Luca, A., Easterbrook, P., Günthard, H.F., Mallal, S., Mussini, C., Dalmau, J., Martinez-Picado, J., Miro, J.M., Obel, N., Wolinsky, S.M., Martinson, J.J., Detels, R., Margolick, J.B., Jacobson, L.P., Descombes, P., Antonarakis, S.E., Beckmann, J.S., O'Brien, S.J., Letvin, N.L., McMichael, A.J., Haynes, B.F., Carrington, M., Feng, S., Telenti, A., Goldstein, D.B., McCarthy, M.I., Fellay, J., Ge, D., Shianna, K.V., Colombo, S., Ledergerber, B., Cirulli, E.T., Urban, T.J., Zhang, K., Gumbs, C.E., Smith, J. P., Castagna, A., Cozzi-Lepri, A., De Luca, A., Easterbrook, P., Günthard, H.F., Mallal, S., Mussini, C., Dalmau, J., Martinez-Picado, J., Miro, J.M., Obel, N., Wolinsky, S.M., Martinson, J.J., Detels, R., Margolick, J.B., Jacobson, L.P., Descombes, P., Antonarakis, S.E., Beckmann, J.S., O'Brien, S.J., Letvin, N.L., McMichael, A.J., Haynes, B.F., Carrington, M., Feng, S., Telenti, A., Goldstein, D.B., and McCarthy, M.I.

Abstract

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.

Published
2009

7. Effects of CCR5-Δ 32, CCR2-64I, and SDF-1 3′A Alleles on HIV-1 Disease Progression: An International Meta-Analysis of Individual-Patient Data

Author

Ioannidis, J.P.A., Rosenberg, P.S., Goedert, J.J., Ashton, L.J., Benfield, T.L., Buchbinder, S.P., Coutinho, R.A., Eugen-Olsen, J., Gallart, T., Katzenstein, T.L., Kostrikis, L.G., Kuipers, H., Louie, L.G., Mallal, S.A., Margolick, J.B., Martinez, O.P., Meyer, L., Michael, N.L., Operskalski, E., Pantaleo, G., Rizzardi, G.P., Schuitemaker, H., Sheppard, H.W., Stewart, G.J., Theodorou, I.D., Ullum, H., Vicenzi, E., Vlahov, D., Wilkinson, D., Workman, C., Zagury, J-F, O'Brien, T.R., Ioannidis, J.P.A., Rosenberg, P.S., Goedert, J.J., Ashton, L.J., Benfield, T.L., Buchbinder, S.P., Coutinho, R.A., Eugen-Olsen, J., Gallart, T., Katzenstein, T.L., Kostrikis, L.G., Kuipers, H., Louie, L.G., Mallal, S.A., Margolick, J.B., Martinez, O.P., Meyer, L., Michael, N.L., Operskalski, E., Pantaleo, G., Rizzardi, G.P., Schuitemaker, H., Sheppard, H.W., Stewart, G.J., Theodorou, I.D., Ullum, H., Vicenzi, E., Vlahov, D., Wilkinson, D., Workman, C., Zagury, J-F, and O'Brien, T.R.

Abstract

The burgeoning information on the human genome creates opportunities and challenges for studies of disease associations. Because genetic differences often produce modest effects, many patients must be studied to reach definitive conclusions. In the absence of a single large study, meta-analysis of individual-patient data (1 - 3) from smaller studies offers a way to assemble an adequate sample size. This approach is based on a unifying protocol that has standardized analytic definitions. When the protocol is applied to data contributed by most investigators working in a field, this method can provide more convincing results than a simple pooling of data or a meta-analysis of published reports (3). A meta-analysis of individual-patient data is also superior to a meta-analysis of published reports for examining differences in reported results.

Published
2001

10. Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study

Author

Brown, T.T., Cole, S.R., Li, X., Kingsley, L.A., Palella, F.J., Riddler, S.A., Vissche, B.R., Margolick, J.B., and Dobs, A.S.

Subjects
Drug therapy, Research, Dosage and administration, Diabetes mellitus -- Drug therapy -- Research, HIV infections -- Drug therapy -- Research, Antiretroviral agents -- Dosage and administration -- Research, Diabetes -- Drug therapy -- Research, Antiviral agents -- Dosage and administration -- Research, HIV infection -- Drug therapy -- Research
Abstract

Brown TT, Cole SR, Li X, Kingsley LA, Palella FJ, Riddler SA, Visscher BR, Margolick JB, Dobs AS: Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the [...]

Published
2005

12. Changes in T-lymphocyte subsets in intravenous drug users with HIV-1 infection.

Author

Margolick, J.B. and Munoz, A.

Subjects
*HIV
Abstract

Evaluates changes in T-cell subsets in prevalent human immunodeficiency virus type 1 (HIV-1) seronegative and seropositive intravenous drug users (IVDU) and in HIV-1 seropositive IVDUs with known time of seroconversion. Methods; Results; Conclusion; AIDS Links to Intravenous Experiences (ALIVE) study; Investigation of four specific factors for their possible effects on the rate of change in CD4 cells among seropositive IVDUs; Zidovudine; More.

Published
1992
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13. Reduced adenylyl cyclase activation with no decrease in @b-adrenergic receptors in basenji greyhound leukocytes: Relevance to @b-adrenergic responses in airway smooth muscle

Author

Emala, C.W., Levine, M.A., Aryana, A., Margolick, J.B., and Hirshman, C.A.

Abstract

Mononuclear leukocytes (MNLs) have been used as a model of @b-adrenergic responsiveness of airway smooth muscle, but the relevance of this model remains controversial. The basenji greyhound (BG) dog model of airway hyperresponsiveness shares some features with human asthma, and airway smooth muscle shows a selective impairment in isoproterenol-stimulated adenylyl cyclase activity. In this study, MNL membranes were obtained from these same dogs, and the @b-adrenergic receptor-adenylyl cyclase cascade function was compared with that in airway smooth muscle. @b-Adrenergic receptor numbers and affinities for iodine 125-cyanopindolol were similar in the two dog groups (receptor numbers [B"m"a"x] = 441 +/- 101 and 447 +/- 61 fmol/mg protein and dissociation constant [K"d] = 269 +/- 44 and 312 +/- 60 pmol/L for mongrel and BG MNLs, respectively). Quantities of the G "s@a protein were not different in the membranes as determined by immunoblotting. Stimulation of adenylyl cyclase by isoproterenol (100 @mmol/L) was impaired in MNL membranes of BG membranes (22% +/- 4% increase over guanosine triphosphate [10 @mmol/L]) compared with mongrel membranes (47% +/- 8.6% increase over guanosine triphosphate [10 @mmol/L], p < 0.05). Stimulation of adenylyl cyclase by prostaglandin E"1 (10 @mmol/L), NaF (10 mmol/L), or forskolin (10 @mmol/L) did not differ in membranes from the two groups. No difference was found in the lymphocyte subsets in the two groups as determined by flow cytometry. These findings are qualitatively similar to studies of trachealis muscle membranes from these same dogs. We have found a selective impairment of isoproterenol stimulation of adenylyl cyclase in membranes prepared from MNLs of the BG dog, which was previously found in airway smooth muscle membranes despite no decrease in numbers of @b-adrenergic receptors. (J A LLERGY CLIN I MMUNOL 1995;95:860-7.)

Published
1995
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14. Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection

Author

Mellors, J.W., Munoz, A., Giorgi, J.V., Margolick, J.B., Tassoni, C.J., Gupta, P., Kingsley, L.A., Todd, J.A., Saah, A.J., Detels, R., Phair, J.P., and Rinaldo, C.R.

Subjects
AIDS (Disease) -- Development and progression, Viremia -- Health aspects, HIV (Viruses) -- Measurement, CD4 lymphocytes -- Measurement, HIV infection -- Prognosis
Abstract

Mellors, J.W.; Munoz, A.; Giorgi, J.V.; Margolick, J.B.; Tassoni, C.J.; Gupta, P.; Kingsley, L.A.; Todd, J.A.; Saah, A.J.; Detels, R.; Phair, J.P.; Rinaldo, C.R. "Plasma Viral Load and CD4(+) Lymphocytes [...]

Published
1997

15. T-helper lymphocyte count: TRAx CD4 test kit versus conventional flow cytometry

Author

Saah, A.J., Spruill, C., Hoover, D.R., Prevots, R., Taylor, E., Margolick, J.B., and Vlahov, D.

Subjects
CD4 lymphocytes -- Measurement, Enzyme-linked immunosorbent assay -- Evaluation, Flow cytometry -- Evaluation
Abstract

According to an abstract submitted by the authors to the 11th International Conference on AIDS, held July 7-12, 1996, in Vancouver, British Columbia, "OBJECTIVE: To evaluate a newly developed enzyme [...]

Published
1996

16. Relationship between infectious cell-associated human immunodeficiency virus type 1 load, T lymphocyte subsets, and stage of infection in homosexual men

Author

Margolick, J.B., Farzadegan, H., Hoover, D.R., and Saah, A.J.

Subjects
Gay men -- Health aspects, HIV infection -- Development and progression
Abstract

According to the authors' abstract of an article published in Journal of Infectious Diseases, "The relationship between cell-associated infectious human immunodeficiency virus type 1 (HIV) load (infectious units/10(6) peripheral blood [...]

Published
1996

18. Effect of influenza vaccination on human immunodeficiency virus type 1 load: a randomized, double-blind, placebo-controlled study

Author

Glesby, M.J., Hoover, D.R., Farzdegan, H., Margolick, J.B., and Saah, A.J.

Subjects
Influenza vaccines -- Physiological aspects, HIV infection -- Physiological aspects
Abstract

According to the authors' abstract of an article published in Journal of Infectious Diseases, "To determine if vaccination induces replication of human immunodeficiency virus type 1 (HIV-1), 42 HIV-1-infected subjects [...]

Published
1997

19. Survival in HIV-infected patients who have received zidovudine: comparison of combination therapy with sequential monotherapy and continued zidovudine monotherapy

Author

Graham, N.M.H., Hoover, D.R., Park, L.P., Stein, D.S., Phair, J.P., Mellors, J.W., Detels, R., Saah, A.J., Taylor, E., Margolick, J.B., Markham, R., Mcarthur, J., Farzadegan, H., Armenian, H., Chmiel, J.S., Cohen, B., Wesch, J., and Wolinsky, S.

Subjects
HIV infection -- Drug therapy, Zidovudine -- Evaluation, Drug therapy, Combination -- Evaluation
Abstract

According to the authors' abstract of an article published in Annals of Internal Medicine, "BACKGROUND: Among patients who begin receiving zidovudine during intermediate-stage human immunodeficiency virus (HIV) infection, it is [...]

Published
1996

20. Existence and failure of T-cell homeostasis prior to AIDS onset in HIV-infected injection drug users

Author

Galai, N., Margolick, J.B., Astemborski, J., and Vlahov, D.

Subjects
Homeostasis -- Physiological aspects, HIV infection -- Physiological aspects, T cells -- Physiological aspects, AIDS (Disease) -- Development and progression
Abstract

According to the authors' abstract of an article published in Clinical Immunology and Immunopathology, "Prior studies, based on populations of homosexual men, have shown that during HIV infection, levels of [...]

Published
1996

21. Lack of sensitivity of HIV-1 primary isolates to IFNA is not associated with disease progression

Author

Kunzi, M.S., Farzadegan, H., Margolick, J.B., Vlahov, D., and Pitha, P.M.

Subjects
Interferon alpha -- Physiological aspects, HIV (Viruses) -- Reproduction, Drug resistance -- Physiological aspects
Abstract

According to an abstract submitted by the authors to the Annual Meeting of the International Society for Interferon and Cytokine Research, held October 2-7, 1994, in Budapest, Hungary, "IFN inhibits [...]

Published
1994

22. Direct comparison of the relationship between clinical outcome and change in CD4+ lymphocytes in human immunodeficiency virus-positive homosexual men and injecting drug users

Author

Margolick, J.B., Munoz, A., Vlahov, D., Astemborski, J., Solomon, L., He, X.Y., Nelson, K.E., and Saah, A.J.

Subjects
HIV patients -- Physiological aspects, Drug addicts -- Physiological aspects, CD4 lymphocytes -- Measurement
Abstract

According to the authors' abstract of an article published in Archives of Internal Medicine, "Background and Methods: To compare rates of decline of CD4(+) lymphocytes among human immunodeficiency virus-positive lymphocytes [...]

Published
1994

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