1. Long-Chain Polyunsaturated Fatty Acids (LC-PUFA) During Early Development
- Author
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Paul Hamosh, Margit Hamosh, Margaret A Kemper, Nicole M. Orr, Amaryllis Gil, and Theresa R. Henderson
- Subjects
chemistry.chemical_classification ,medicine.medical_specialty ,Fetus ,food and beverages ,Adipose tissue ,eye diseases ,Accretion (finance) ,chemistry.chemical_compound ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Docosahexaenoic acid ,Internal medicine ,Lactation ,medicine ,Weaning ,lipids (amino acids, peptides, and proteins) ,Arachidonic acid ,sense organs ,human activities ,Polyunsaturated fatty acid - Abstract
Long-chain polyunsaturated fatty acids (LC-PUFA) accretion (essential for growth and neural development) was studied from late fetal throughout weaning age in the ferret, a species with maternal LC-PUFA sufficiency during pregnancy and lactation. The data show that a) accretion rate of LC-PUFA is rapid during early postnatal development, b) milk LC-PUFA decrease during lactation, c) adipose tissur, LC-PUFA level is directly related to milk LC-PUFA level, while accretion in brair and liver exceeds dietary intake, d) accretion of arachidonic acid occurs earlier than docosahexaenoic acid, suggesting earlier development of n6-fatty acid endogenous synthesis.
- Published
- 2001
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