85 results on '"Maret, E."'
Search Results
2. Reduced Pulmonary Artery Distensibility Is Independently Associated With 2-year Mortality In Transcatheter Aortic Valve Replacement Patients: A Retrospective Longitudinal Study
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Turner, V., primary, Willemink, M., additional, Kim, J., additional, Maret, E., additional, Watkins, A., additional, Fearon, W., additional, Haddad, F., additional, and Fleischmann, D., additional
- Published
- 2021
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3. P158Mangafodipir as an adjunct to percutaneous coronary intervention in patients with acute myocardial infarction
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El-Saadi, W, Maret, E, Andersson, R, Puskar, W, Ali, M, Skogvard, P, Koch, A, and Karlsson, JE
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- 2014
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4. Moderated Posters sessionThe emerging role of 2-dimensional strain in clinical practice: 13/12/2013, 14: 00–18: 00Location: Moderated Poster area
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Nylander, E, Hard, L, Andersson, J, Lindqvist, P, Remmets, J, Winter, R, Andersson, B, Roijer, A, Gao, S, and Maret, E
- Published
- 2013
5. Poster Session: Right ventricular systolic function
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Maret, E, Ahlander, B-M, Bjorklund, P-G, and Engvall, JE
- Published
- 2012
6. Validation of Non-Invasive RAMP-Testing for HeartMate 3
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Najjar, E., primary, Thorvaldsen, T., additional, Kristensen, A. Hallberg, additional, Dalen, M., additional, Lund, L.H., additional, Eriksson, M.J., additional, and Maret, E., additional
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- 2020
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7. P740 Right ventricular function evaluated by conventional echocardiography and strain imaging: study in young adults born preterm with and without lung disease
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Bolander, V, primary, Maret, E, additional, Um Bergstrom, P, additional, Skold, M, additional, and Eriksson, M J, additional
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- 2020
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8. P1423 Significantly higher 1-year mortality rate in patients undergoing TAVR with higher right ventricular volumes, as calculated by pre-procedural CT angiography
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Maret, E, primary, Rozenbaum, Z, additional, Lax, L, additional, Shmilovich, H, additional, Finkelstein, A, additional, Steinvil, A, additional, Halkin, A, additional, Banai, S, additional, Cohen, D, additional, Topilsky, Y, additional, Berliner, S, additional, Fleischmann, D, additional, and Aviram, G, additional
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- 2020
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9. P3662Relationships between bacteria and echocardiographic manifestations in infective endocarditis - data from the Swedish endocarditis registry
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Damlin, A, primary, Westling, K, additional, Maret, E, additional, Caidahl, K, additional, and Eriksson, M J, additional
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- 2019
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10. Pathophysiology and clinical implications of lower respiratory tract infection (LRTI) with respiratory enteric orphan virus (reovirus): Background and experimental evidence
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Maret E. Bernard
- Subjects
Orphan virus ,Lower respiratory tract infection ,Immunology ,medicine ,Respiratory system ,Biology ,medicine.disease ,Virology ,Pathophysiology - Published
- 2019
11. P439Understanding the geometric basis for longitudinal left atrial strain and its relation to left ventricular measures
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Soundappan, D, primary, Frojdh, F, additional, Loewenstein, D, additional, Sorensson, P, additional, Sigfridsson, A, additional, Maret, E, additional, Schelbert, E, additional, Kozor, R, additional, and Ugander, M, additional
- Published
- 2019
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12. 332Diastolic dysfunction grading with a comprehensive CMR protocol - feasibility and agreement compared to echocardiography
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Afonso, J G, primary, Fyrdahl, A, additional, Wieslander, B, additional, Thalen, S, additional, Reiter, G, additional, Reiter, U, additional, Jin, N, additional, Maret, E, additional, Eriksson, M, additional, Caidahl, K, additional, Sorensson, P, additional, Sigfridsson, A, additional, and Ugander, M, additional
- Published
- 2019
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13. The value of a new cardiac magnetic resonance imaging protocol in Myocardial Infarction with Non-obstructive Coronary Arteries (MINOCA) – a case-control study using historical controls from a previous study with similar inclusion criteria
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Tornvall, Per, primary, Brolin, E. B., additional, Caidahl, K., additional, Cederlund, K., additional, Collste, O., additional, Daniel, M., additional, Ekenbäck, C., additional, Jensen, J., additional, Y-Hassan, S., additional, Henareh, L., additional, Hofman-Bang, C., additional, Lyngå, P., additional, Maret, E., additional, Sarkar, N., additional, Spaak, J., additional, Sundqvist, M., additional, Sörensson, P., additional, Ugander, M., additional, and Agewall, S., additional
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- 2017
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14. Perception in Sport: Basketball.
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Allard, Fran, Graham, Sheree, and Paarsalu, Maret E.
- Abstract
Performance of basketball players and nonplayers was compared on a task requiring the recall of slides of basketball games after a 4-second view of each slide. All slides viewed depicted basketball games; one half of the slides contained structured game information (slide represented an offensive playing progress) and the other half of the slides showed unstructured game information (slide represented a turnover or rebound). As has been found for skilled chess, bridge, and Go players, basketball players were superior to nonplayers in recall for structured slides only. Furthermore, players were superior to nonplayers in a recognition task for both structured and unstructured slides, showing that players' superiority in the experimental tasks is a function of encoding information to a deeper level than nonplayers. [ABSTRACT FROM AUTHOR]
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- 1980
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15. Left ventricular diastolic function, assessed by echocardiography and tissue Doppler imaging, is a strong predictor of cardiovascular events, superior to global left ventricular longitudinal strain, in patients with type 2 diabetes
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Blomstrand, P., primary, Engvall, M., additional, Festin, K., additional, Lindstrom, T., additional, Lanne, T., additional, Maret, E., additional, Nystrom, F. H., additional, Maret-Ouda, J., additional, Ostgren, C. J., additional, and Engvall, J., additional
- Published
- 2015
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16. These abstracts have been selected for VIEWING only as ePosters and in print. ePosters will be available on Screen A & B throughout the meeting, Print Posters at the times indicated below. Please refer to the PROGRAM for more details.
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Secchi, F., primary, Cannao, P., additional, Pluchinotta, F., additional, Butera, G., additional, Carminati, M., additional, Sardanelli, F., additional, Lombardi, M., additional, Monney, P., additional, Piccini, D., additional, Rutz, T., additional, Vincenti, G., additional, Coppo, S., additional, Koestner, S., additional, Stuber, M., additional, Schwitter, J., additional, Romana, P., additional, Francesco, S., additional, Gianfranco, B., additional, Mario, C., additional, Massimo, L., additional, Alizadeh Sani, Z., additional, Vojdan-Parast, M., additional, Alimohammadi, M., additional, Sarafan-Sadeghi, S., additional, Seifi, A., additional, Fallahabadi, H., additional, Karami Tanha, F., additional, Jamshidi, M., additional, Hesamy, M., additional, Bonello, B., additional, Sorensen, C., additional, Fouilloux, V., additional, Gorincour, G., additional, Mace, L., additional, Fraisse, A., additional, Jacquier, A., additional, de Meester, C., additional, Amzulescu, M., additional, Bouzin, C., additional, Boileau, L., additional, Melchior, J., additional, Boulif, J., additional, Lazam, S., additional, Pasquet, A., additional, Vancrayenest, D., additional, Vanoverschelde, J., additional, Gerber, B., additional, Loudon, M., additional, Bull, S., additional, Bissell, M., additional, Joseph, J., additional, Neubauer, S., additional, Myerson, S., additional, Dorniak, K., additional, Hellmann, M., additional, Rawicz-Zegrzda, D., additional, W sierska, M., additional, Sabisz, A., additional, Szurowska, E., additional, Heiberg, E., additional, Dudziak, M., additional, Kwok, T., additional, Chin, C., additional, Dweck, M., additional, Hadamitzky, M., additional, Nadjiri, J., additional, Hendrich, E., additional, Pankalla, C., additional, Will, A., additional, Schunkert, H., additional, Martinoff, S., additional, Sonne, C., additional, Pepe, A., additional, Meloni, A., additional, Terrazzino, F., additional, Spasiano, A., additional, Filosa, A., additional, Bitti, P., additional, Tangari, C., additional, Restaino, G., additional, Resta, M., additional, Ricchi, P., additional, Tudisca, C., additional, Grassedonio, E., additional, Positano, V., additional, Piraino, B., additional, Romano, N., additional, Keilberg, P., additional, Midiri, M., additional, Macchi, S., additional, Ambrosio, D., additional, De Marchi, D., additional, Chiodi, E., additional, Salvatori, C., additional, Artang, R., additional, Bogachkov, A., additional, Botelho, M., additional, Bou-Ayache, J., additional, Vazquez, M., additional, Carr, J., additional, Collins, J., additional, Maret, E., additional, Ahlander, B., additional, Bjorklund, P., additional, Engvall, J., additional, Cimermancic, R., additional, Inage, A., additional, Mizuno, N., additional, Santarelli, M., additional, Izzi, G., additional, Maddaloni, D., additional, Landini, L., additional, Carulli, G., additional, Oliva, E., additional, Arcioni, F., additional, Fraticelli, V., additional, Toia, P., additional, Renne, S., additional, Rizzo, M., additional, Reinstadler, S., additional, Klug, G., additional, Feistritzer, H., additional, Aschauer, A., additional, Schocke, M., additional, Franz, W., additional, Metzler, B., additional, Melonil, A., additional, Positanol, V., additional, Roccamo, G., additional, Argento, C., additional, Benni, M., additional, De Marchil, D., additional, Missere, M., additional, Prezios, P., additional, Salvatoril, C., additional, Pepel, A., additional, Rossi, G., additional, Cirotto, C., additional, Filati, G., additional, Preziosi, P., additional, Mongeon, F., additional, Fischer, K., additional, Teixeira, T., additional, Friedrich, M., additional, Marcotte, F., additional, Zenge, M., additional, Schmidt, M., additional, Nadar, M., additional, Chevre, P., additional, Rohner, C., additional, Mouratoglou, S., additional, Kallifatidis, A., additional, Giannakoulas, G., additional, Grapsa, J., additional, Kamperidis, V., additional, Pitsiou, G., additional, Stanopoulos, I., additional, Hadjimiltiades, S., additional, Karvounis, H., additional, Ahmed, N., additional, Lawton, C., additional, Ghosh Dastidar, A., additional, Frontera, A., additional, Jackson, A., additional, Cripps, T., additional, Diab, I., additional, Duncan, E., additional, Thomas, G., additional, Bucciarelli-Ducci, C., additional, Kannoly, S., additional, Gosling, O., additional, Ninan, T., additional, Fulford, J., additional, Dalrymple-Haym, M., additional, Shore, A., additional, Bellenger, N., additional, Alegret, J., additional, Beltran, R., additional, Martin, M., additional, Mendoza, M., additional, Elisabetta, C., additional, Teresa, C., additional, Zairo, F., additional, Marcello, N., additional, Clorinda, M., additional, Bruna, M., additional, Vincenzo, P., additional, Alessia, P., additional, Giorgio, B., additional, Mair, J., additional, Kremser, C., additional, Aschauer, S., additional, Tufaro, C., additional, Kammerlander, A., additional, Pfaffenberger, S., additional, Marzluf, B., additional, Bonderman, D., additional, Mascherbauer, J., additional, Kliegel, A., additional, Sailer, A., additional, Brustbauer, R., additional, Sedivy, R., additional, Mayr, H., additional, Manessi, M., additional, Castelvecchio, S., additional, Votta, E., additional, Stevanella, M., additional, Menicanti, L., additional, Secchi, F., additional, Redaelli, A., additional, Reiter, U., additional, Reiter, G., additional, Kovacs, G., additional, Greiser, A., additional, Olschewski, H., additional, Fuchsjager, M., additional, Babayev, J., additional, Mlynarski, R., additional, Mlynarska, A., additional, Sosnowski, M., additional, Pontone, G., additional, Bertella, E., additional, Petulla, M., additional, Russo, E., additional, Innocenti, E., additional, Baggiano, A., additional, Mushtaq, S., additional, Gripari, P., additional, Andreini, D., additional, Tondo, C., additional, Nyktari, E., additional, Izgi, C., additional, Haidar, S., additional, Wage, R., additional, Keegan, J., additional, Wong, T., additional, Mohiaddin, R., additional, Durante, A., additional, Rimoldi, O., additional, Laforgia, P., additional, Gianni, U., additional, Benedetti, G., additional, Cava, M., additional, Damascelli, A., additional, Laricchia, A., additional, Ancona, M., additional, Aurelio, A., additional, Pizzetti, G., additional, Esposito, A., additional, Margonato, A., additional, Colombo, A., additional, De Cobelli, F., additional, Camici, P., additional, Zvaigzne, L., additional, Sergejenko, S., additional, Kal js, O., additional, Ripley, D., additional, Swarbrick, D., additional, Hossain, E., additional, Chawner, R., additional, Moore, J., additional, Aquaro, G., additional, Barison, A., additional, Masci, P., additional, Todiere, G., additional, Strata, E., additional, Di Bella, G., additional, Monasterio, F., additional, Levelt, E., additional, Mahmod, M., additional, Ntusi, N., additional, Ariga, R., additional, Upton, R., additional, Piechnick, S., additional, Francis, J., additional, Schneider, J., additional, Stoll, V., additional, Davis, A., additional, Karamitsos, T., additional, Leeson, P., additional, Holloway, C., additional, Clarke, K., additional, Karwat, K., additional, Tomala, M., additional, Miszalski-Jamka, K., additional, Mrozi ska, S., additional, Kowalczyk, M., additional, Mazur, W., additional, Kereiakes, D., additional, Nessler, J., additional, Zmudka, K., additional, Ja wiec, P., additional, Miszalski-Jamka, T., additional, Ben Yaacoub-Kzadri, I., additional, Harguem, S., additional, Bennaceur, R., additional, Ganzoui, I., additional, Ben Miled, A., additional, Mnif, N., additional, Rodriguez Palomares, J., additional, Ortiz, J., additional, Tejedor, P., additional, Lee, D., additional, Wu, E., additional, Bonow, R., additional, Khanji, M., additional, Castiello, T., additional, Westwood, M., additional, Petersen, S., additional, Storti, S., additional, Quota, A., additional, Smacchia, M., additional, Paci, C., additional, Vallone, A., additional, Valeri, G., additional, keilberg, P., additional, Gargani, L., additional, Guiducci, S., additional, Pugliese, N., additional, Pingitore, A., additional, Cole, B., additional, Douglas, H., additional, Rodden, S., additional, Horan, P., additional, Harbinson, M., additional, Johnston, N., additional, Dixon, L., additional, Choudhary, P., additional, Hsu, C., additional, Grieve, S., additional, Semsarian, C., additional, Richmond, D., additional, Celermajer, D., additional, Puranik, R., additional, Hinojar Baydes, R., additional, Varma, N., additional, Goodman, B., additional, Khan, S., additional, Arroyo Ucar, E., additional, Dabir, D., additional, Schaeffter, T., additional, Nagel, E., additional, Puntmann, V., additional, Hinojar, R., additional, Ucar, E., additional, Ngah, N., additional, Kuo, N., additional, D'Cruz, D., additional, Gaddum, N., additional, Foote, L., additional, Schnackenburg, B., additional, Higgins, D., additional, Nucifora, G., additional, Muser, D., additional, Morocutti, G., additional, Gianfagna, P., additional, Zanuttini, D., additional, Piccoli, G., additional, Proclemer, A., additional, Prati, G., additional, Vitrella, G., additional, Allocca, G., additional, Buttignoni, S., additional, Delise, P., additional, Sinagra, G., additional, Silva, G., additional, Almeida, A., additional, David, C., additional, Francisco, A., additional, Magalhaes, A., additional, Placido, R., additional, Menezes, M., additional, Guimaraes, T., additional, Mendes, A., additional, Nunes Diogo, A., additional, Aneq, M., additional, Papavassiliu, T., additional, Sandberg, R., additional, Schimpf, R., additional, Schoenberg, S., additional, Borggrefe, M., additional, Doesch, C., additional, Tamin, S., additional, Tan, L., additional, Joshi, S., additional, Memon, S., additional, Tangcharoen, T., additional, Prasertkulchai, W., additional, Yamwong, S., additional, Sritara, P., additional, Binti Ngah, N., additional, Cruz, D., additional, Rebellato, L., additional, Daleffe, E., additional, Facchin, D., additional, Melao, F., additional, Paiva, M., additional, Pinho, T., additional, Martins, E., additional, Vasconcelos, M., additional, Madureira, A., additional, Macedo, F., additional, Ramos, I., additional, Maciel, M., additional, Agoston-Coldea, L., additional, Marjanovic, Z., additional, Hadj Khelifa, S., additional, Kachenoura, N., additional, Lupu, S., additional, Soulat, G., additional, Farge-Bancel, D., additional, Mousseaux, E., additional, Dastidar, A., additional, Augustine, D., additional, McAlindon, E., additional, Leite, S., additional, Sousa, C., additional, Rangel, I., additional, El ghannudi, S., additional, Lefoulon, A., additional, Noel, E., additional, Germain, P., additional, Doutreleau, S., additional, Jeung, M., additional, Gangi, A., additional, Roy, C., additional, Pisciella, L., additional, Zachara, E., additional, Federica, R., additional, Emdin, M., additional, Baydes, R., additional, Mahmoud, I., additional, and Jackson, T., additional
- Published
- 2014
- Full Text
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17. Poster Session: Right ventricular systolic function
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Altman, M., primary, Bergerot, C., additional, Thibault, H., additional, Aussoleil, A., additional, Skuldadt Davidsen, E., additional, Barthelet, M., additional, Derumeaux, G. A., additional, Grapsa, J., additional, Zimbarra Cabrita, I., additional, Afilalo, J., additional, Paschou, S., additional, Dawson, D., additional, Durighel, G., additional, O'regan, D., additional, Howard, L., additional, Gibbs, J., additional, Nihoyannopoulos, P., additional, Morenate Navio, M., additional, Mesa Rubio, M., additional, Ortega, M. D., additional, Ruiz Ortiz, M., additional, Castillo Bernal, F., additional, Del Pino, C. L., additional, Toledano, F., additional, Alvarez-Ossorio, M. P., additional, Ojeda Pineda, S., additional, Lezo Cruz-Conde, J. S. D., additional, Jasaityte, R., additional, Claus, P., additional, Teske, A., additional, Herbots, L., additional, Verheyden, B., additional, Rademakers, F., additional, D'hooge, J., additional, Tocchetti, C. G., additional, Coppola, C., additional, Rea, D., additional, Quintavalle, C., additional, Guarino, L., additional, Castaldo, N., additional, De Lorenzo, C., additional, Condorelli, G., additional, Arra, C., additional, Maurea, N., additional, Voilliot, D., additional, Huttin, O., additional, Camara, Y., additional, Djaballah, W., additional, Carillo, S., additional, Zinzius, P., additional, Sellal, J., additional, Angioi, M., additional, Juilliere, Y., additional, Selton-Suty, C., additional, Dobrowolski, P., additional, Klisiewicz, A., additional, Florczak, E., additional, Prejbisz, A., additional, Szwench, E., additional, Rybicka, J., additional, Januszewicz, A., additional, Hoffman, P., additional, Jurado Roman, A., additional, De Dios Perez, S., additional, De Nicolas, J. M. M., additional, Diaz Anton, B., additional, Rubio Alonso, B., additional, Martin Asenjo, R., additional, Mayordomo Gomez, S., additional, Villagraz Tecedor, L., additional, Blazquez, L., additional, De Meneses, R. T., additional, Bernard, A., additional, Hernandez, A. I., additional, Reynaud, A., additional, Lerclercq, C., additional, Daubert, J., additional, Donal, E., additional, Arjan Singh, R., additional, Sivarani, S., additional, Lim, S., additional, Azman, W., additional, Almeida, M., additional, Cardim, N., additional, Fonseca, V., additional, Carmelo, V., additional, Santos, S., additional, Santos, T., additional, Toste, J., additional, Kosmala, W., additional, Orda, A., additional, Karolko, B., additional, Mysiak, A., additional, Przewlocka-Kosmala, M., additional, Farsalinos, K., additional, Tsiapras, D., additional, Kyrzopoulos, S., additional, Avramidou, E., additional, Vassilopoulou, D., additional, Voudris, V., additional, Hayrapetyan, H., additional, Adamyan, K., additional, Montero Cabezas, J., additional, Granda Nistal, C., additional, Garcia Aranda, B., additional, Sanchez Sanchez, V., additional, Sestito, A., additional, Lamendola, P., additional, Di Franco, A., additional, Lauria, C., additional, Lanza, G., additional, Kukucka, M., additional, Unbehaun, A., additional, Buz, S., additional, Mladenow, A., additional, Kuppe, H., additional, Pasic, M., additional, Habazettl, H., additional, Gemma, D., additional, Montoro Lopez, N., additional, De Celix, M. G. R., additional, Lopez Fernandez, T., additional, De Torres Alba, F., additional, Del Valle, D. I., additional, Ramirez, U., additional, Mesa, J., additional, Moreno Yanguela, M., additional, Lopez Sendon, J., additional, Eveborn, G. W., additional, Schirmer, H., additional, Lunde, P., additional, Heggelund, G., additional, Rasmussen, K., additional, Wang, Z., additional, Lasota, B., additional, Mizia-Stec, K., additional, Mizia, M., additional, Chmiel, A., additional, Adamczyk, T., additional, Chudek, J., additional, Gasior, Z., additional, Venkatesh, A., additional, Johnson, J., additional, Sahlen, A., additional, Brodin, L., additional, Winter, R., additional, Shahgaldi, K., additional, Manouras, A., additional, Valbuena, S., additional, Iniesta, A., additional, Lopez, T., additional, De Torres, F., additional, Salinas, P., additional, Garcia, S., additional, Moreno, M., additional, Lopez-Sendon, J., additional, Lebid, I., additional, Kobets, T., additional, Kuzmenko, T., additional, Katsanos, S., additional, Yiu, K., additional, Clavel, M., additional, Nina Ajmone, N., additional, Van Der Kley, F., additional, Rodes Cabau, J., additional, Schalij, M., additional, Bax, J., additional, Pibarot, P., additional, Delgado, V., additional, Fusini, L., additional, Tamborini, G., additional, Muratori, M., additional, Gripari, P., additional, Marsan, N., additional, Cefalu', C., additional, Ewe, S., additional, Maffessanti, F., additional, Pepi, M., additional, Hasselberg, N., additional, Haugaa, K., additional, Petri, H., additional, Berge, K., additional, Leren, T., additional, Bundgaard, H., additional, Edvardsen, T., additional, Ancona, R., additional, Comenale Pinto, S., additional, Caso, P., additional, Coppola, M., additional, Rapisarda, O., additional, Cavallaro, C., additional, Vecchione, F., additional, D'onofrio, A., additional, Calabro', R., additional, Rimbas, R., additional, Mihaila, S., additional, Enescu, O., additional, Patrascu, N., additional, Dragoi, R., additional, Rimbas, M., additional, Pop, C., additional, Vinereanu, D., additional, Gustafsson, S., additional, Morner, S., additional, Gronlund, C., additional, Suhr, O., additional, Lindqvist, P., additional, Di Bella, G., additional, Zito, C., additional, Minutoli, F., additional, Madaffari, A., additional, Cusma Piccione, M., additional, Mazzeo, A., additional, Massimo, R., additional, Pasquale, M., additional, Vita, G., additional, Carerj, S., additional, Rangel, I., additional, Goncalves, A., additional, Sousa, C., additional, Correia, A., additional, Martins, E., additional, Silva-Cardoso, J., additional, Macedo, F., additional, Maciel, M., additional, Pfeiffer, B., additional, Rigopoulos, A., additional, Seggewiss, H., additional, Alvarez Fuente, M., additional, Sainz Costa, T., additional, Medrano, C., additional, Navarro, M., additional, Blazquez Gamero, D., additional, Ramos, J., additional, Mellado, M., additional, De Jose, M., additional, Munoz, M., additional, Maroto, E., additional, Gargani, L., additional, Gosciniak, P., additional, Pratali, L., additional, Agoston, G., additional, Bruni, C., additional, Guiducci, S., additional, Matucci Cerinic, M., additional, Varga, A., additional, Sicari, R., additional, Picano, E., additional, Zhao, C., additional, Mei, M., additional, Yeung, C., additional, Siu, C., additional, Tse, H., additional, Florescu, M., additional, Magda, L., additional, Mincu, R., additional, Daha, I., additional, Stanescu, C. M., additional, Chirila, L., additional, Baicus, C., additional, Vlase, A., additional, Dan, G., additional, Montoro Lopez, M., additional, Florez Gomez, R., additional, Alonso Ladreda, A., additional, Itziar Soto, C., additional, Rios Blanco, J., additional, Guzman Martinez, G., additional, Lichodziejewska, B., additional, Kurnicka, K., additional, Goliszek, S., additional, Kostrubiec, M., additional, Dzikowska-Diduch, O., additional, Ciurzynski, M., additional, Labyk, A., additional, Krupa, M., additional, Palczewski, P., additional, Pruszczyk, P., additional, De Sousa, C. C., additional, Vigario, A., additional, Pinho, T., additional, Silva Cardoso, J., additional, Park, S.-J., additional, Song, J.-E., additional, Lee, Y.-J., additional, Ha, M.-R., additional, Chang, S.-A., additional, Choi, J.-O., additional, Lee, S.-C., additional, Park, S., additional, Oh, J., additional, Van De Bruaene, A., additional, De Meester, P., additional, Buys, R., additional, Vanhees, L., additional, Delcroix, M., additional, Voigt, J., additional, Budts, W., additional, Blundo, A., additional, Buccheri, S., additional, Monte, I. P., additional, Leggio, S., additional, Tamburino, C., additional, Sotaquira, M., additional, Lang, R., additional, Caiani, E., additional, Floria, M., additional, De Roy, L., additional, Xhaet, O., additional, Blommaert, D., additional, Jamart, J., additional, Gerard, M., additional, Deceuninck, O., additional, Marchandise, B., additional, Seldrum, S., additional, Schroeder, E., additional, Unsworth, B., additional, Sohaib, S., additional, Kulwant-Kaur, K., additional, Malcolme-Lawes, L., additional, Kanagaratnam, P., additional, Malik, I., additional, Ren, B., additional, Mulder, H., additional, Haak, A., additional, Van Stralen, M., additional, Szili-Torok, T., additional, Pluim, J., additional, Geleijnse, M., additional, Bosch, J., additional, Baglini, R., additional, Amaducci, A., additional, D'ancona, G., additional, Van Den Oord, S., additional, Akkus, Z., additional, Ten Kate, G., additional, Renaud, G., additional, Sijbrands, E., additional, De Jong, N., additional, Van Der Lugt, A., additional, Van Der Steen, A., additional, Schinkel, A., additional, Bjallmark, A., additional, Larsson, M., additional, Grishenkov, D., additional, Brodin, L.-A., additional, Brismar, T., additional, Paradossi, G., additional, Sveen, K. A., additional, Nerdrum, T., additional, Hanssen, K., additional, Dahl-Jorgensen, K., additional, Steine, K., additional, Cimino, S., additional, Pedrizzetti, G., additional, Tonti, G., additional, Canali, E., additional, Petronilli, V., additional, Cicogna, F., additional, Arcari, L., additional, De Luca, L., additional, Iacoboni, C., additional, Agati, L., additional, Abdel Moneim, S. S., additional, Eifert Rain, S., additional, Bernier, M., additional, Bhat, G., additional, Hagen, M., additional, Bott-Kitslaar, D., additional, Castello, R., additional, Wilansky, S., additional, Pellikka, P., additional, Mulvagh, S., additional, Delithanasis, I., additional, Celutkiene, J., additional, Kenny, C., additional, Monaghan, M., additional, Park, W., additional, Hong, G., additional, Son, J., additional, Lee, S., additional, Kim, U., additional, Park, J., additional, Shin, D., additional, Kim, Y., additional, Toutouzas, K., additional, Drakopoulou, M., additional, Aggeli, C., additional, Felekos, I., additional, Nikolaou, C., additional, Synetos, A., additional, Stathogiannis, K., additional, Tsiamis, E., additional, Siores, E., additional, Stefanadis, C., additional, Plicht, B., additional, Kahlert, P., additional, Grave, T., additional, Buck, T., additional, Konorza, T., additional, Gursoy, M., additional, Gokdeniz, T., additional, Astarcioglu, M., additional, Bayram, Z., additional, Cakal, B., additional, Karakoyun, S., additional, Kalcik, M., additional, Acar, R., additional, Kahveci, G., additional, Ozkan, M., additional, Tsang, W., additional, Weinert, L., additional, Yurdakul, S., additional, Avci, B., additional, Sahin, S., additional, Dilekci, B., additional, Aytekin, S., additional, Arenga, F., additional, Hascoet, S., additional, Martin, R., additional, Dulac, Y., additional, Peyre, M., additional, Benzouid, C., additional, Hadeed, K., additional, Acar, P., additional, Zakarkaite, D., additional, Skorniakov, V., additional, Zvironaite, V., additional, Grabauskiene, V., additional, Burca, J., additional, Ciparyte, L., additional, Laucevicius, A., additional, Di Salvo, G., additional, Rea, A., additional, D'aiello, A., additional, Del Gaizo, F., additional, Pergola, V., additional, D'andrea, A., additional, Pacileo, G., additional, Calabro, R., additional, Russo, M., additional, Dedobbeleer, C., additional, Hadefi, A., additional, Naeije, R., additional, Unger, P., additional, Mornos, C., additional, Cozma, D., additional, Ionac, A., additional, Mornos, A., additional, Valcovici, M., additional, Pescariu, S., additional, Petrescu, L., additional, Hu, K., additional, Liu, D., additional, Niemann, M., additional, Herrmann, S., additional, Cikes, M., additional, Stoerk, S., additional, Knop, S., additional, Ertl, G., additional, Bijnens, B., additional, Weidemann, F., additional, De Knegt, M., additional, Biering-Sorensen, T., additional, Sogaard, P., additional, Sivertsen, J., additional, Jensen, J., additional, Mogelvang, R., additional, Lam, W., additional, Tang, M., additional, Chan, K., additional, Yang, Y., additional, Fang, F., additional, Sun, J., additional, Yu, C., additional, Lam, Y., additional, Panoulas, V., additional, Sulemane, S., additional, Bratsas, A., additional, Konstantinou, K., additional, Francone, M., additional, Schau, T., additional, Seifert, M., additional, Ridjab, D., additional, Schoep, M., additional, Gottwald, M., additional, Neuss, M., additional, Meyhoefer, J., additional, Zaenker, M., additional, Butter, C., additional, Tarr, A., additional, Stoebe, S., additional, Pfeiffer, D., additional, Hagendorff, A., additional, Maret, E., additional, Ahlander, B.-M., additional, Bjorklund, P.-G., additional, Engvall, J., additional, Staskiewicz, G., additional, Czekajska-Chehab, E., additional, Adamczyk, P., additional, Siek, E., additional, Przybylski, P., additional, Maciejewski, R., additional, Drop, A., additional, Jimenez Rubio, C., additional, Isasti Aizpurua, G., additional, Miralles Ibarra, J., additional, Al-Mallah, M., additional, Somg, T., additional, Alam, S., additional, Chattahi, J., additional, Zweig, B., additional, Dhanalakota, K., additional, Boedeker, S., additional, Ananthasubramaniam, K., additional, Park, C., additional, March, K., additional, Jones, S., additional, Mayet, J., additional, Tillin, T., additional, Chaturvedi, N., additional, Hughes, A., additional, Hamodraka, E., additional, Kallistratos, E., additional, Karamanou, A., additional, Tsoukas, T., additional, Mavropoulos, D., additional, Kouremenos, N., additional, Zaharopoulou, I., additional, Nikolaidis, N., additional, Kremastinos, D., additional, Manolis, A., additional, Loboz-Rudnicka, M., additional, Jaroch, J., additional, Bociaga, Z., additional, Kruszynska, E., additional, Ciecierzynska, B., additional, Dziuba, M., additional, Dudek, K., additional, Uchmanowicz, I., additional, Loboz-Grudzien, K., additional, Silva, D., additional, Magalhaes, A., additional, Jorge, C., additional, Cortez-Dias, N., additional, Carrilho-Ferreira, P., additional, Silva Marques, J., additional, Portela, I., additional, Pascoa, C., additional, Nunes Diogo, A., additional, Brito, D., additional, Roosens, B., additional, Bala, G., additional, Droogmans, S., additional, Hostens, J., additional, Somja, J., additional, Delvenne, E., additional, Schiettecatte, J., additional, Lahoutte, T., additional, Van Camp, G., additional, and Cosyns, B., additional
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- 2012
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18. Pathophysiology and clinical implications of lower respiratory tract infection (LRTI) with respiratory enteric orphan virus (reovirus): Background and experimental evidence
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Bernard, Maret E., primary
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19. Perception in Sport: Basketball
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Fran Allard, Sheree Graham, and Maret E. Paarsalu
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Stimulus Complexity ,Basketball ,Recall ,Perception ,media_common.quotation_subject ,ComputingMilieux_PERSONALCOMPUTING ,Offensive ,Basketball games ,Psychology ,media_common ,Cognitive psychology ,Task (project management) - Abstract
Performance of basketball players and nonplayers was compared on a task requiring the recall of slides of basketball games after a 4-second view of each slide. All slides viewed depicted basketball games; one half of the slides contained structured game information (slide represented an offensive play in progress) and the other half of the slides showed unstructured game information (slide represented a turnover or rebound). As has been found for skilled chess, bridge, and Go players, basketball players were superior to nonplayers in recall for structured slides only. Furthermore, players were superior to nonplayers in a recognition task for both structured and unstructured slides, showing that players' superiority in the experimental tasks is a function of encoding information to a deeper level than nonplayers.
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- 1980
20. P439 Understanding the geometric basis for longitudinal left atrial strain and its relation to left ventricular measures.
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Soundappan, D, Frojdh, F, Loewenstein, D, Sorensson, P, Sigfridsson, A, Maret, E, Schelbert, E, Kozor, R, and Ugander, M
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LEFT heart ventricle ,CONFERENCES & conventions ,MAGNETIC resonance imaging ,LEFT heart atrium ,ANATOMY - Published
- 2019
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21. 332 Diastolic dysfunction grading with a comprehensive CMR protocol - feasibility and agreement compared to echocardiography.
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Afonso, J G, Fyrdahl, A, Wieslander, B, Thalen, S, Reiter, G, Reiter, U, Jin, N, Maret, E, Eriksson, M, Caidahl, K, Sorensson, P, Sigfridsson, A, and Ugander, M
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CONFERENCES & conventions ,HEART ventricle diseases ,DIASTOLE (Cardiac cycle) ,ECHOCARDIOGRAPHY ,LEFT heart ventricle ,MAGNETIC resonance imaging ,DIAGNOSIS - Published
- 2019
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22. Pathophysiology and clinical implications of lower respiratory tract infection (LRTI) with respiratory enteric orphan virus (reovirus): Background and experimental evidence
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Bernard, Maret E. and Bernard, Maret E.
23. Actor's apartment collapses
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Maret, E. Jack
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Actors -- Personal narratives ,Apartment houses -- New York - Published
- 1979
24. P158 Mangafodipir as an adjunct to percutaneous coronary intervention in patients with acute myocardial infarction.
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El-Saadi, W, Maret, E, Andersson, R, Puskar, W, Ali, M, Skogvard, P, Koch, A, and Karlsson, JE
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- *
PULMONARY infarction , *FEASIBILITY studies , *BIOMARKERS , *REPERFUSION injury , *CARDIAC magnetic resonance imaging , *SUPEROXIDE dismutase - Abstract
Background: Animal studies have shown that the superoxide dismutase mimetic mangafodipir (manganese dipyridoxyl diphosphate) with an active metabolite (manganese dipyridoxyl ethyldiamine) reduces reperfusion injuries and thereby infarct size in acute myocardial infarction (MI). In this small pilot trial we attempted to assess the feasibility of applying mangafodipir as a cardioprotective adjunct to Percutaneus Coronary Intervention (PCI).Methods: 20 patients with their first acute ST-elevation MI (STEMI) were assigned into two groups receiving an intravenous bolus dose of mangafodipir, 2 μmol per kilogram of body weight, or saline (control group) immediately before performing PCI. Infarct size was assessed by ST-segment changes, release of plasma biomarkers and cardiac magnetic resonance imaging (MRI) at routine follow up.Results: On cardiac MRI, the mangafodipir group revealed a smaller mean infarct size (26.2% scar vs 32.5%) and a higher mean ejection fraction (47.7 % vs 41.8 %), despite a significant prolonged ischemia time (205 min vs 144 min). ST-segment elevation also regressed more rapidly in the mangafodipir group, whereas there were no apparent differences in biomarker release.Conclusions: In this small local feasibility study with a skewed distribution of patients the administration of mangafodipir at the time of reperfusion was associated with a non-significant smaller scar tissue and better ejection fraction compared with placebo. The results give the impression that mangafodipir may reduce infarct size in STEMI patients, however this require confirmation in a larger clinical trial. No adverse effects of mangafodipir administration were detected. [ABSTRACT FROM PUBLISHER]
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- 2014
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25. Pathophysiology and clinical implications of lower respiratory tract infection (LRTI) with respiratory enteric orphan virus (reovirus): Background and experimental evidence
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Bernard, Maret E.
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- Immunology, Pathology
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Background. Respiratory viral infection early in life is a predominant factor in the inception of episodic wheezing and development of asthma amongst young children [1] and a serious health challenge. Previous studies of lower respiratory tract infections (LRTI) with respiratory syncytial virus (RSV) in animal models have indicated that early life viral exposure results in dysregulated neuroimmune interactions and altered synthesis/release of pro-inflammatory neuropeptides generating increased airway reactivity and neurogenic-inflammation. Similar to RSV, respiratory enteric orphan virus (Reovirus) is a common respiratory pathogen associated with pulmonary infections in children. Also, reovirus pulmonary infection has been shown to induce increased collagen deposition and be associated with the pathogenesis of bronchiolitis obliterans with organizing pneumonia (BOOP). In this study, we investigated the effects of reovirus exposure on physiological airway responses and whether these responses were associated with neurogenic inflammation and airway remodeling.;Methods. Adult (12 weeks) and weanling (2 weeks) Fisher-344 (F-344) rats were infected with reovirus or a pathogen-free vehicle and the changes in airway vascular permeability, neurotrophin expression, inflammatory response and protein content were measured at either 5 or 30 days after infection to determine changes in neurogenic inflammation and airway remodeling.;Results. Neurogenic inflammation increased in all treated animals 5 days after inoculation and up to 30 days in adult rats. This effect was not associated with any changes in nerve growth factor (NGF) and brain-derived neurotrphic factor (BDNF) expression in any animals at both time points. All treated animals developed acute pneumonia which resolved at 30 days. However, weanling rats showed mild peri-alveolar fibrosis at 30 days.;Conclusions. Reovirus potentiates neurogenic inflammation in rat airways. This effect is not associated with changes in neurotrophin expression. In weanling rats, reovirus infection induced peri-alveolar fibrosis suggesting that early exposure may carry long-term effects which may be clinically relevant.
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- 2010
26. Moderated Posters session * The emerging role of 2-dimensional strain in clinical practice: 13/12/2013, 14:00-18:00 * Location: Moderated Poster area
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Muraru, D, Mihaila, S, Piasentini, E, Casablanca, S, Naso, P, Puma, L, Ermacora, D, Zoppellaro, G, Iliceto, S, Badano, LP, Farsalinos, K, Daraban, A, Unlu, S, Pellikka, P, Lancellotti, P, Thomas, J, Badano, L, Voigt, J-U, Force, EACVI-ASE Standardization Task, Antoine, C, Dadfarin-Bejou, A, Gallet, R, Bremont, C, Dubois-Rande, JL, Lim, P, Acosta Martinez, J, Lopez-Haldon, JE, Rodriguez-Rodriguez, JE, Lopez-Pardo, F, Martinez-Martinez, A, Nylander, E, Hard, L, Andersson, J, Lindqvist, P, Remmets, J, Winter, R, Andersson, B, Roijer, A, Gao, S, Maret, E, Esposito, R, Santoro, C, Raia, R, Schiano-Lomoriello, V, Lauria, R, Arpino, G, De Simone, G, Galderisi, M, El Ghannudi, S, Samet, H, Germain, P, Jeung, MI-Y, Gangi, A, Roy, C, Marta, L, Placido, R, Ramalho, A, Cortez-Dias, N, Nobre Menezes, M, Santos, L, Infante Oliveira, E, Martins, S, Almeida, AG, Nunes Diogo, A, Bech-Hanssen, O, Pergola, V, Fadel, BM, Di Salvo, G, Buccheri, S, Mangiafico, S, Lavanco, V, Bottari, VE, Arcidiacono, A, Tamburino, C, and Monte, I P
- Abstract
Purpose: Intervendor differences of 2D/3D strain measurements are well known issues that significantly limit their adoption in clinical routine. Whether a similar discordance affects also the quantitation of left ventricular (LV) geometry and function and the LV normative ranges for different 3D echo softwares has not been investigated. Methods: Full-volume LV 3D data sets (35±6 vps) have been acquired in 235 healthy volunteers (44±14 years, range 18–76 years, 104 men) using a GE Vivid E9 scanner. Exclusion criteria were athletic training, pregnancy, body mass index > 30 kg/m2, and poor apical acoustic window. An experienced researcher analyzed all LV data sets using a vendor-specific software (EchoPac BT12, GE Healthcare, N). Three months later, the same researcher repeated the analysis with a vendor-independent DICOM-based software (4D LV Analysis 3.1, TomTec, D), being blinded from previous measurements. Results: Despite the differences in LV parameters obtained with the two softwares were statistically significant (Table), Bland-Altman analysis shows a clinically irrelevant bias and reasonable limits of agreement for LV volumes and EF. LV mass measurements by EchoPac were slightly larger than those by TomTec and had relatively wider limits of agreement than LV volumes. Both softwares showed significant and consistent relationships of LV 3D parameters with age, gender and body size in healthy subjects (p<0.0001 for all relationships). Conclusion: Our data shows that converting 3D data sets in DICOM format does not significantly affect the normative values for LV volumes and ejection fraction with respect to those provided by proprietary software. The availability of vendor-independent softwares and respective normative values will encourage the adoption of 3D echocardiography for routine LV quantitation in multi-vendor echo labs.
Vendor-specific software Vendor-independent software p Bias Limits of agreement End-diastolic volume (ml) 108±26 106±25 0.002 2 -17 to +21 End-systolic volume (ml) 40±11 39±11 0.516 0.2 -8 to +9 Stroke-volume (ml) 68±16 66±15 <0.001 2 -13 to +17 Ejection fraction (%) 64±4 63±4 0.007 1 -6 to +7 Mass (g) 133±22 124±28 <0.001 9 -24 to +43 - Published
- 2013
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27. Cardiac biopsies reveal differences in transcriptomics between left and right ventricle in patients with or without diagnostic signs of heart failure.
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Frisk C, Das S, Eriksson MJ, Walentinsson A, Corbascio M, Hage C, Kumar C, Ekström M, Maret E, Persson H, Linde C, and Persson B
- Subjects
- Humans, Heart Ventricles, Stroke Volume physiology, Echocardiography, Gene Expression Profiling, Biopsy, Ventricular Function, Left, Heart Failure diagnosis, Heart Failure genetics, Ventricular Dysfunction, Left
- Abstract
New or mild heart failure (HF) is mainly caused by left ventricular dysfunction. We hypothesised that gene expression differ between the left (LV) and right ventricle (RV) and secondly by type of LV dysfunction. We compared gene expression through myocardial biopsies from LV and RV of patients undergoing elective coronary bypass surgery (CABG). Patients were categorised based on LV ejection fraction (EF), diastolic function and NT-proBNP into pEF (preserved; LVEF ≥ 45%), rEF (reduced; LVEF < 45%) or normal LV function. Principal component analysis of gene expression displayed two clusters corresponding to LV and RV. Up-regulated genes in LV included natriuretic peptides NPPA and NPPB, transcription factors/coactivators STAT4 and VGLL2, ion channel related HCN2 and LRRC38 associated with cardiac muscle contraction, cytoskeleton, and cellular component movement. Patients with pEF phenotype versus normal differed in gene expression predominantly in LV, supporting that diastolic dysfunction and structural changes reflect early LV disease in pEF. DKK2 was overexpressed in LV of HFpEF phenotype, potentially leading to lower expression levels of β-catenin, α-SMA (smooth muscle actin), and enhanced apoptosis, and could be a possible factor in the development of HFpEF. CXCL14 was down-regulated in both pEF and rEF, and may play a role to promote development of HF., (© 2024. The Author(s).)
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- 2024
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28. Prognostic utility and characterization of left ventricular hypertrophy using global thickness.
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Lundin M, Heiberg E, Nordlund D, Gyllenhammar T, Steding-Ehrenborg K, Engblom H, Carlsson M, Atar D, van der Pals J, Erlinge D, Borgquist R, Khoshnood A, Ekelund U, Nickander J, Themudo R, Nordin S, Kozor R, Bhuva AN, Moon JC, Maret E, Caidahl K, Sigfridsson A, Sörensson P, Schelbert EB, Arheden H, and Ugander M
- Subjects
- Humans, Prognosis, Heart Ventricles, Ventricular Remodeling, Ventricular Function, Left, Hypertrophy, Left Ventricular, Heart Failure
- Abstract
Cardiovascular magnetic resonance (CMR) can accurately measure left ventricular (LV) mass, and several measures related to LV wall thickness exist. We hypothesized that prognosis can be used to select an optimal measure of wall thickness for characterizing LV hypertrophy. Subjects having undergone CMR were studied (cardiac patients, n = 2543; healthy volunteers, n = 100). A new measure, global wall thickness (GT, GTI if indexed to body surface area) was accurately calculated from LV mass and end-diastolic volume. Among patients with follow-up (n = 1575, median follow-up 5.4 years), the most predictive measure of death or hospitalization for heart failure was LV mass index (LVMI) (hazard ratio (HR)[95% confidence interval] 1.16[1.12-1.20], p < 0.001), followed by GTI (HR 1.14[1.09-1.19], p < 0.001). Among patients with normal findings (n = 326, median follow-up 5.8 years), the most predictive measure was GT (HR 1.62[1.35-1.94], p < 0.001). GT and LVMI could characterize patients as having a normal LV mass and wall thickness, concentric remodeling, concentric hypertrophy, or eccentric hypertrophy, and the three abnormal groups had worse prognosis than the normal group (p < 0.05 for all). LV mass is highly prognostic when mass is elevated, but GT is easily and accurately calculated, and adds value and discrimination amongst those with normal LV mass (early disease)., (© 2023. The Author(s).)
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- 2023
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29. Reduced Pulmonary Artery Distensibility Predicts Persistent Pulmonary Hypertension and 2-Year Mortality in Patients with Severe Aortic Stenosis Undergoing TAVR.
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Turner V, Maret E, Kim JB, Codari M, Hinostroza V, Mastrodicasa D, Watkins AC, Fearon WF, Fischbein MP, Haddad F, Willemink MJ, and Fleischmann D
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- Humans, Aortic Valve, Pulmonary Artery diagnostic imaging, Treatment Outcome, Longitudinal Studies, Retrospective Studies, Risk Factors, Severity of Illness Index, Transcatheter Aortic Valve Replacement, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Aortic Valve Stenosis complications, Hypertension, Pulmonary diagnostic imaging, Hypertension, Pulmonary complications
- Abstract
Rationale and Objectives: Post-TAVR persistent pulmonary hypertension (PH) is a better predictor of poor outcome than pre-TAVR PH. In this longitudinal study we sought to evaluate whether pulmonary artery (distensibility (D
PA ) measured on preprocedural ECG-gated CTA is associated with persistent-PH and 2-year mortality after TAVR., Materials and Methods: Three hundred and thirty-six patients undergoing TAVR between July 2012 and March 2016 were retrospectively included and followed for all-cause mortality until November 2017. All patients underwent retrospectively ECG-gated CTA prior to TAVR. Main pulmonary artery (MPA) area was measured in systole and in diastole. DPA was calculated as: [(area-MPAmax -area-MPAmin )/area-MPAmax ]%. ROC analysis was performed to assess the AUC for persistent-PH. Youden Index was used to determine the optimal threshold of DPA for persistent-PH. Two groups were compared based on a DPA threshold of 8% (specificity of 70% for persistent-PH). Kaplan-Meier, Cox proportional-hazard, and logistic regression analyses were performed. The primary clinical endpoint was defined as persistent-PH post-TAVR. The secondary endpoint was defined as all-cause mortality 2 years after TAVR., Results: Median follow-up time was 413 (interquartiles 339-757) days. A total of 183 (54%) had persistent-PH and 68 (20%) patients died within 2-years after TAVR. Patients with DPA <8% had significantly more persistent-PH (67% vs 47%, p<0.001) and 2-year deaths (28% vs 15%, p=0.006), compared to patients with DPA >8%. Adjusted multivariable regression analyses showed that DPA <8% was independently associated with persistent-PH (OR 2.10 [95%-CI 1.3-4.5], p=0.007) and 2-year mortality (HR 2.91 [95%-CI 1.5-5.8], p=0.002). Kaplan-Meier analysis showed that 2-year mortality of patients with DPA <8% was significantly higher compared to patients with DPA ≥8% (mortality 28% vs 15%; log-rank p=0.003)., Conclusion: DPA on preprocedural CTA is independently associated with persistent-PH and two-year mortality in patients who undergo TAVR., Competing Interests: Declaration of Competing Interest None., (Copyright © 2023 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.)- Published
- 2023
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30. CMR Is Often Abnormal Despite Normal Echocardiography in Suspected Myocardial Infarction With Nonobstructed Coronary Arteries.
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Sundqvist MG, Sörensson P, Ekenbäck C, Lundin M, Agewall S, Brolin EB, Cederlund K, Collste O, Daniel M, Jensen J, Y-Hassan S, Henareh L, Hofman-Bang C, Lyngå P, Maret E, Sarkar N, Spaak J, Winnberg O, Caidahl K, Ugander M, and Tornvall P
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- Humans, Predictive Value of Tests, Echocardiography, Coronary Angiography, Coronary Vessels diagnostic imaging, Myocardial Infarction diagnostic imaging
- Published
- 2023
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31. Four- to seven-year follow-up of pharmacological postconditioning with mangafodipir as an adjunct to primary PCI in ST-segment elevation myocardial infarction.
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El-Saadi W, Engvall J, Karlsson JE, and Maret E
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- Humans, Stroke Volume, Ventricular Function, Left, Follow-Up Studies, Treatment Outcome, ST Elevation Myocardial Infarction diagnostic imaging, ST Elevation Myocardial Infarction drug therapy, Percutaneous Coronary Intervention adverse effects
- Abstract
Introduction: Adverse left ventricular remodelling (AR) develops over time in approximately 30% of patients with a history of coronary artery disease. AR manifests as a structural change in the left ventricle (LV) in terms of increased volumes and reduced left ventricular ejection fraction (LVEF). Manganese dipyridoxyl diphosphate (mangafodipir) has demonstrated interesting cardioprotective features in acute myocardial ischaemia. Pharmacological postconditioning (PP) with mangafodipir as an adjunct to primary percutaneous coronary intervention may possibly reduce the development of AR over time in ST-elevation myocardial infarction (STEMI). The aim of this 4-7-year follow-up study is to investigate the potential benefits of PP with mangafodipir in STEMI patients., Method: Thirteen out of the initial 20 patients that were included in the primary study of Karlsson et al. were followed up between April and June 2017. The study group underwent review of the hospital records, a clinical examination with ECG and blood sample analysis before cardiac magnetic resonance examination of the patient. LVEF, left ventricular diastolic volume, left ventricular end systolic volume, LV mass and myocardial strain in all directions were computed., Results: The PP group showed a decrease in LV volume, mass and higher LVEF at follow-up (p < 0.05) while the individual response of the placebo group showed features that are seen in AR. Although there was no difference in myocardial strain, measurement for the PP-group was higher in absolute terms., Conclusion: Pharmacological postconditioning with mangafodipir in STEMI demonstrated cardioprotective features compared to the placebo group at follow-up. This article is protected by copyright. All rights reserved., (© 2023 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine.)
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- 2023
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32. Health-related quality-of-life up to one year after myocardial infarction with non-obstructive coronary arteries.
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Berg E, Agewall S, Brolin EB, Caidahl K, Cederlund K, Collste O, Daniel M, Ekenbäck C, Jensen J, Y-Hassan S, Henareh L, Maret E, Spaak J, Sörensson P, Tornvall P, and Lyngå P
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- Female, Humans, Male, Middle Aged, Coronary Angiography methods, Quality of Life, Risk Factors, MINOCA, Myocardial Infarction complications
- Abstract
Aims: Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) are a heterogenous group and previous studies indicate a decreased Health-related quality-of-life (HRQoL) compared with patients with myocardial infarction with obstructive coronary artery disease and healthy individuals. However, longitudinal data are scarce. Therefore, the aim was to explore HRQoL among patients with MINOCA during a one-year period after the acute event in comparison with a group of healthy individuals and to describe HRQoL in patients with Takotsubo Syndrome (TTS)., Methods and Results: Patients with MINOCA were recruited from five hospitals in the Stockholm region (SMINC-2 study, clinical trials: NCT2318498). Patients responded to the HRQoL questionnaire RAND-36 between days 2-4, after 6 and 12 months respectively. A sample of population-based individuals was used as a comparison group. A total of 142 MINOCA patients, (70% women) mean age of 56 years, responded. A population-based sample of 317 volunteers (66% women) mean age of 57 years. Patients with MINOCA scored lower than the comparison group in the domains role functioning physical, social functioning, and role functioning emotional (P = 0.01-0.02) at 12 months. In these domains of HRQoL there was no improvement in MINOCA patients during 12 months follow-up. In the domains of energy/fatigue vitality and emotional well-being the scores improved and were similar to the comparison group at 12 months. Patients with TTS scored generally lower on RAND-36 than MINOCA patients without TTS., Conclusion: Physical, social, and emotional functioning did not improve during the first year after MINOCA, indicating a need for increased follow-up including psychological support., (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.)
- Published
- 2023
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33. The effects of iron injection on blood doping biomarkers in dried blood spots.
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Loria F, Maret E, Schobinger C, Kuuranne T, Grabherr S, and Leuenberger N
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- Humans, Reticulocytes metabolism, Iron, Biomarkers, Ferritins, Hemoglobins analysis, 5-Aminolevulinate Synthetase, Doping in Sports methods
- Abstract
Iron supplementation is not considered as a doping method; however, it can affect the levels of several biomarkers of the hematologic module of the athlete biological passport (ABP), such as the reticulocyte percentage (%RET) and hemoglobin (HGB) level. Thus, iron injection could be a confounding factor in antidoping analyses. Previous studies have suggested that the HGB level and the expression levels of reticulocyte-related-mRNAs, such as 5'-aminolevulinate synthase 2 (ALAS2) and carbonic anhydrase 1 (CA1), could be promising biomarkers for the ABP and detectable in dried blood spots (DBSs). Therefore, in this study, we examined the impact of iron injection on the levels of these potential biomarkers in DBSs. Reticulocyte-related-mRNAs analyses were performed by RT-qPCR. Ferritin level in DBS was measured with enzyme-linked immunosorbent assay (ELISA) method. Notably, there were no significant effects of iron supplementation on the levels of ALAS2 and CA1 mRNAs but by contrast, the %RET and immature reticulocyte fraction (IRF) measured in whole blood increased significantly following iron injection. As expected, iron supplementation increased the ferritin level significantly in both serum and DBS samples. In conclusion, these findings reinforce the specificity of reticulocyte-related mRNAs in DBSs as biomarkers of blood doping to target in antidoping analyses., (© 2022 John Wiley & Sons Ltd.)
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- 2023
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34. Can transthoracic echocardiography be used to a greater extent in the diagnostics of infective endocarditis to avoid unnecessary transoesophageal examinations without jeopardising accuracy?
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Damlin A, Eriksson MJ, and Maret E
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- Humans, Positron Emission Tomography Computed Tomography adverse effects, Echocardiography methods, Echocardiography, Transesophageal methods, Endocarditis, Bacterial, Endocarditis diagnostic imaging, Endocarditis etiology
- Abstract
Background: Infective endocarditis (IE) is a serious condition that requires prompt diagnosis and treatment. Transthoracic echocardiography (TTE) is usually the initial imaging modality, however transoesophageal echocardiography (TOE) is sometimes necessary because of its higher sensitivity for IE. Yet, TOE may imply an increased risk of complications. This project aims to evaluate whether TTE can be used to a greater extent in the diagnostics of IE to avoid unnecessary TOE examinations without jeopardizing diagnostic accuracy., Methods: Data from all TOE examinations performed on patients hospitalized with clinical suspicion of IE between 2019-05-01 and 2020-04-30 at a university hospital in Stockholm, Sweden, were obtained and analysed. Variables included for analysis were age, sex, blood culture results, aetiology, results from TOE, number of TOEs during the inclusion period, results from positron emission tomography/computed tomography (PET/CT), new regurgitation, cardiac murmur, previous IE, prosthetic valve, predisposing factors, i.e. cardiac comorbidities, injection drug use, fever, vascular phenomena, and immunological phenomena. To assess associations between predisposing factors or aetiology of IE and TOE findings, chi square tests and logistic regression models were used. For continuous variables, linear regression was used for comparisons of means and quantile regression was used for comparisons of medians. P < 0.05 was considered significant., Results: In total 195 TOE examinations (Table 1) from 160 patients were included, of which 61 (31%) were positive for IE. In total, 36 examinations had negative TTE prior to TOE of which 32 (86%) also had negative TOE. Of the 5 (14%) negative TTE prior to TOE that had positive TOE, all had cardiovascular implantable electronic device (CIED) and/or prosthetic valves., Conclusions: The existing recommendations for TOE in patients with clinical suspicion of IE are probably broad enough not to miss patients with IE, but there might be an unnecessarily large number of patients being referred for TOE with negative results. Negative TTE examination with good image quality and no CIED or prosthetic valves, may be sufficient without jeopardizing the IE diagnosis., (© 2023. The Author(s).)
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- 2023
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35. Comprehensive Follow-Up Cardiac Magnetic Resonance of Patients With Myocardial Infarction With Nonobstructive Coronary Arteries.
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Nickander J, Ekenbäck C, Agewall S, Bacsovics Brolin E, Caidahl K, Cederlund K, Collste O, Daniel M, Jensen J, Y-Hassan S, Henareh L, Hofman-Bang C, Lyngå P, Maret E, Sarkar N, Spaak J, Winnberg O, Sundqvist M, Ugander M, Tornvall P, and Sörensson P
- Subjects
- Humans, Follow-Up Studies, MINOCA, Predictive Value of Tests, Magnetic Resonance Spectroscopy, Coronary Vessels diagnostic imaging, Coronary Vessels pathology, Coronary Angiography, Risk Factors, Myocardial Infarction diagnostic imaging, Myocardial Infarction therapy, Myocardial Infarction pathology, Coronary Artery Disease pathology
- Published
- 2023
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36. Baseline characteristics of 547 new onset heart failure patients in the PREFERS heart failure study.
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Linde C, Ekström M, Eriksson MJ, Maret E, Wallén H, Lyngå P, Wedén U, Cabrera C, Löfström U, Stenudd J, Lund LH, Persson B, Persson H, and Hage C
- Subjects
- Biomarkers, Echocardiography, Female, Humans, Natriuretic Peptide, Brain, Peptide Fragments, Prognosis, Stroke Volume physiology, Ventricular Function, Left physiology, Heart Failure diagnostic imaging
- Abstract
Aim: We present the baseline characteristics of the PREFERS Stockholm epidemiological study on the natural history and course of new onset heart failure (HF) aiming to improve phenotyping focusing on HF with preserved left ventricular ejection fraction (HFpEF) pathophysiology., Methods and Results: New onset HF patients diagnosed in hospital or at outpatient HF clinics were included at five Stockholm hospitals 2015-2018 and characterized by N-terminal pro brain natriuretic peptide (NT-proBNP), biomarkers, echocardiography, and cardiac magnetic resonance imaging (subset). HFpEF [left ventricular ejection fraction (LVEF) ≥ 50%] was compared with HF with mildly reduced LVEF (HFmrEF; LVEF 41-49%) and with HF with reduced LVEF (HFrEF; LVEF ≤ 40%). We included 547 patients whereof HFpEF (n = 137; 25%), HFmrEF (n = 61; 11%), and HFrEF (n = 349; 64%). HFpEF patients were older (76; 70-81 years; median; interquartile range) than HFrEF (67; 58-74; P < 0.001), more often women (49% vs. 30%; P < 0.001), and had significantly higher comorbidity burden. They more often had atrial fibrillation, hypertension, and renal dysfunction. NT-proBNP was lower in HFpEF (896; 462-1645 ng/L) than in HFrEF (1160; 563-2370; P = 0.005). In HFpEF, left ventricular (LV) diameters and volumes were smaller (P < 0.001) and septal and posterior wall thickness and relative wall thickness higher (P < 0.001). E/é ≥ 14 was present in 26% of HFpEF vs. 32% of HFrEF (P = 0.017) and left atrial volume index > 34 mL/m
2 in 57% vs. 61% (P = 0.040). HFmrEF patients were intermediary between HFpEF and HFrEF for LV mass, LV volumes, and RV volumes but had the highest proportion of left ventricular hypertrophy and the lowest proportion of elevated E/é., Conclusions: Phenotype data in new onset HF patients recruited in a broad clinical setting showed that 25% had HFpEF, were older, more often women, and had greater comorbidity burden. PREFERS is well suited to further explore biomarker and imaging components of HFpEF pathophysiology and may contribute to the emerging knowledge of HF epidemiology., Clinical Trial Registration: Clinicaltrials.gov identifier: NCT03671122., (© 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)- Published
- 2022
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37. [Cosmetic breast implants can influence cardiac imaging].
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Forsberg L, Maret E, Rickenlund A, and Åström Aneq M
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- Artifacts, Echocardiography methods, Female, Heart, Humans, Magnetic Resonance Imaging, Breast Implants adverse effects
- Abstract
Cosmetic breast implants are increasing in popularity. The presence of foreign material overlying the anterior wall of the heart can influence cardiac imaging and lead to misdiagnosis of cardiac disease. Echocardiography is commonly used in patients for evaluation of cardiac structure and function. Breast implants can cause impaired quality of the echocardiographic images because of an interaction between the implant material and the ultrasound beam, and as a consequence this can lead to a decreased diagnostic accuracy. In myocardial perfusion imaging breast implant can induce attenuation artifacts, which can be mistaken for myocardial infarction. The number of indications for cardiac MRI examinations are increasing, but also with this technique the presence of breast implants can induce artefacts that impair the possibilities to optimal quality. Women considering breast augmentation should be informed of the risk that the procedure can result in impaired quality of different cardiac imaging modalities.
- Published
- 2022
38. Thrombosis and Bleeding After Implementation of an Intermediate-Dose Prophylactic Anticoagulation Protocol in ICU Patients With COVID-19: A Multicenter Screening Study.
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Al-Abani K, Kilhamn N, Maret E, and Mårtensson J
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- Anticoagulants adverse effects, Humans, Intensive Care Units, Multicenter Studies as Topic, Observational Studies as Topic, Prospective Studies, COVID-19 complications, Pulmonary Embolism etiology, Thrombosis etiology
- Abstract
Thrombosis and bleeding after implementation of an intermediate-dose prophylactic anticoagulation protocol in intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19): a multicenter screening study Background: Venous thromboembolism (VTE) is common among critically ill patients with COVID-19. Information regarding VTE prevalence and bleeding complications after implementation of intermediate-dose prophylactic anticoagulation in such patients is, however, limited. Methods: We performed a prospective, observational study in 6 ICUs in 2 university-affiliated teaching hospitals in Sweden. After implementation of an intermediate-dose prophylactic anticoagulation protocol, we performed ultrasound screening for proximal lower-extremity deep vein thrombosis (DVT) and collected routine computed tomography pulmonary angiography exam results. Results: A total of 100 COVID-19 patients were included from June 21, 2020, through February 18, 2021. During a median follow-up of 120 (IQR, 89-134) days, we found VTE in 37 patients with the majority (78.4%) being diagnosed after ICU arrival. Overall, 20 patients had proximal lower-extremity DVT with 95% being detected on ultrasound screening; 22 patients had pulmonary vascular thrombosis; and 4 patients had venous thrombosis at other sites. A total of 6 patients had both proximal lower-extremity DVT and pulmonary vascular thrombosis. On univariate logistic regression analysis of 14 baseline characteristics, only pre-existing heart failure was associated with VTE (OR 4.67, 95% CI 1.13-19.34). Major and non-major bleeding occurred in 10 and 18 patients, respectively. Conclusions: In our cohort of ICU patients with COVID-19, we observed a high prevalence of VTE and bleeding complications after implementation of intermediate-dose anticoagulation. In approximately half of patients, VTE was identified on screening ultrasound.
- Published
- 2022
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39. Evaluation of left ventricular diastolic function in patients operated for aortic stenosis.
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Hultkvist H, Nylander E, Tamás É, Svedjeholm R, Engvall J, Holm J, Maret E, and Vánky F
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- Aged, Aged, 80 and over, Female, Humans, Longitudinal Studies, Male, Prospective Studies, Ventricular Function, Left, Aortic Valve diagnostic imaging, Aortic Valve physiopathology, Aortic Valve surgery, Aortic Valve Stenosis blood, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis physiopathology, Aortic Valve Stenosis surgery, Echocardiography, Doppler, Heart Valve Prosthesis Implantation, Natriuretic Peptide, Brain blood, Peptide Fragments blood
- Abstract
Background: Left ventricular diastolic dysfunction is common in patients with aortic valve stenosis (AS) and reportedly affects prognosis after surgical aortic valve replacement (SAVR). Here we investigated whether and how diastolic function (assessed following the most recent guidelines) was affected by SAVR, and whether preoperative diastolic function affected postoperative outcome. We also examined whether long-term mortality was associated with preoperative NT-proBNP and postoperative heart failure (PHF)., Methods: We performed a prospective observational study of 273 patients with AS who underwent AVR with or without concomitant coronary artery bypass surgery. Of these patients, 247 were eligible for assessment of left ventricular (LV) filling pressure. Preoperatively and at the 6-month postoperative follow-up, we measured N-terminal pro-B type natriuretic peptide (NT-proBNP) in serum and assessed diastolic function with Doppler echocardiography. PHF was diagnosed using prespecified criteria. Multivariable logistic regression was performed to explore variables associated with high LV filling pressure. Cox regression was performed to explore variables associated with mortality, accounting for timeto-event., Results: At the time of surgery, 22% (n = 54) of patients had diastolic dysfunction expressed as high LV filling pressure. Of these 54 patients, 27 (50%) showed postoperative diastolic function improvement. Among the 193 patients with preoperative low LV filling pressure, 24 (12%) showed postoperative diastolic function deterioration. Increased long-term mortality was associated with PHF and high preoperative NT-proBNP, but not with preoperative or postoperative diastolic dysfunction. Cox regression revealed the following independent risk factors for long-term mortality: diabetes, renal dysfunction, preoperative NT-proBNP>960 ng/L, age, and male gender., Conclusions: Surgery for aortic stenosis improved diastolic function in patients with high LV filling pressure in 50% of the patients. Our results could not confirm the previously suggested role of diastolic dysfunction as a marker for poor long-term survival after SAVR. Our findings showed that both PHF and high preoperative NT-proBNP were associated with long-term mortality., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2022
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40. Diffusely Increased Myocardial Extracellular Volume With or Without Focal Late Gadolinium Enhancement: Prevalence and Associations With Left Ventricular Size and Function.
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Lundin M, Sörensson P, Maret E, Jenner J, Abdula G, Nickander J, Themudo R, Caidahl K, Kellman P, Sigfridsson A, and Ugander M
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- Female, Fibrosis, Humans, Magnetic Resonance Imaging, Cine, Male, Myocardium pathology, Predictive Value of Tests, Prevalence, Prospective Studies, Ventricular Function, Left, Contrast Media, Gadolinium
- Abstract
Purpose: Myocardial extracellular volume fraction (ECV) using cardiovascular magnetic resonance (CMR) can identify diffuse lesions not detected by late gadolinium enhancement (LGE). We aimed to determine the prevalence of increased ECV and its relation to other CMR findings., Materials and Methods: Consecutive patients (n=609, age median [interquartile range] 53 [39 to 66] y, 62% male) underwent CMR at 1.5 T. Focal lesions on LGE images were noted. ECV in regions without focal LGE findings defined diffuse changes. Pronounced increases in left ventricular (LV) end-diastolic volume index and LV mass index, and pronounced decreases in LV ejection fraction were defined as >3 SD from the sex-specific mean in healthy volunteers., Results: Of 609 patients without amyloidosis or hypertrophic cardiomyopathy, 8% had diffusely increased ECV and 5% of all patients had diffusely increased ECV without any focal LGE findings. Multivariate analysis showed that a pronounced increase in the LV end-diastolic volume index was associated with increased ECV (P=0.001), but not LGE (P=0.52). A pronounced decrease in LV ejection fraction was associated with the presence of LGE (P<0.001), but not with increased ECV (P=0.41)., Conclusions: Eight percent of patients in this clinical cohort with known or suspected heart disease had diffusely increased ECV and 60% of these lacked focal LGE findings. LV size is independently associated with increased ECV, whereas systolic dysfunction is independently associated with LGE. This image-based clinical study demonstrates that ECV-CMR provides additional information negligibly related to the results of LGE imaging, and thereby increases the diagnostic yield of CMR., (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2022
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41. Moderately trained male football players, compared to sedentary male adults, exhibit anatomical but not functional cardiac remodelling, a cross-sectional study.
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Engvall JE, Aneq MÅ, Nylander E, Brudin L, and Maret E
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- Adult, Athletes, Cross-Sectional Studies, Heart Ventricles diagnostic imaging, Humans, Male, Ventricular Function, Left, Ventricular Remodeling, Young Adult, Echocardiography, Three-Dimensional, Football
- Abstract
Background: Elite athletes have been the subject of great interest, but athletes at an intermediate level of physical activity have received less attention in respect to the presence of cardiac enlargement and/or hypertrophy. We hypothesized that playing football, often defined as demanding less endurance components than running or cycling, would still induce remodelling similar to sports with a dominating endurance component., Methods: 23 male football players, age 25+/- 3.9 yrs. underwent exercise testing, 2D- and 3D- echocardiography and cardiac magnetic resonance (CMR). The results were compared with a control group of engineering students of similar age. The athletes exercised 12 h/week and the control subjects 1 h/week, p < 0.001., Results: The football players achieved a significantly higher maximal load at the exercise test (380 W vs 300 W, p < 0.001) as well as higher calculated maximal oxygen consumption, (49.7 vs 37.4 mL x kg
- 1 x min- 1 , p < 0.001) compared to the sedentary group. All left ventricular (LV) volumes assessed by 3DEcho and CMR, as well as CMR left atrial (LA) volume were significantly higher in the athletes (3D-LVEDV 200 vs 154 mL, CMR-LVEDV 229 vs 185 mL, CMR-LA volume 100 vs 89 mL, p < 0.001, p = 0.002 and p = 0.009 respectively). LVEF and RVEF, LV strain by CMR or by echo did not differentiate athletes from sedentary participants. Right ventricular (RV) longitudinal strain, LA and right atrial (RA) strain by CMR all showed similar results in the two groups., Conclusion: Moderately trained intermediate level football players showed anatomical but not functional cardiac remodelling compared to sedentary males., (© 2021. The Author(s).)- Published
- 2021
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42. Plasma catecholamine levels in the acute and subacute stages of takotsubo syndrome: Results from the Stockholm myocardial infarction with normal coronaries 2 study.
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Y-Hassan S, Sörensson P, Ekenbäck C, Lundin M, Agewall S, Brolin EB, Caidahl K, Cederlund K, Collste O, Daniel M, Jensen J, Hofman-Bang C, Lyngå P, Maret E, Sarkar N, Spaak J, Winnberg O, Ugander M, Tornvall P, and Henareh L
- Subjects
- Humans, Metanephrine, Normetanephrine, Adrenal Gland Neoplasms diagnostic imaging, Myocardial Infarction diagnosis, Takotsubo Cardiomyopathy diagnosis
- Abstract
Aims: It is well-accepted that takotsubo syndrome (TS) is characterized by a massive surge of plasma catecholamines despite lack of solid evidence. The objective of this study was to examine the hypothesis of a massive catecholamine elevation in TS by studying plasma-free catecholamine metabolites in patients participating in the Stockholm myocardial infarction (MI) with normal coronaries 2 (SMINC-2) study where TS constituted more than one third of the patients., Methods and Results: The patients included in the SMINC-2 study were classified, according to cardiac magnetic resonance (CMR) imaging findings (148 patients), which was performed at a median of 3 days after hospital admission. Plasma-free catecholamine metabolites; metanephrine, normetanephrine, and methoxy-tyramine were measured on day 2-4 after admission. Catecholamine metabolite levels were available in 125 patients. One hundred and ten (88%) of the 125 patients included in SMINC-2 study, and 38 (86.4%) of the 44 patients with TS had completely normal plasma metanephrine and normetanephrine levels. All patients had normal plasma methoxy-tyramine levels. Fourteen (11.2%) of the 125 patients included in SMINC-2 study, and 5 (11.6%) of the 43 patients with TS had mild elevations (approximately 1.2 times the upper normal limits) of either plasma metanephrine or normetanephrine. One patient with pheochromocytoma-triggered TS had marked elevation of plasma metanephrine and mild elevation of plasma normetanephrine. There were no significant differences between the number or degree of catecholamine metabolite elevations between the different groups of patients with CMR imaging diagnosis included in SMINC-2 study., Conclusion: There was no evidence of massive catecholamine elevations in the acute and subacute stages of TS apart from one patient with pheochromocytoma-induced TS. Most of the TS patients had normal catecholamine metabolites indicating that blood-borne catecholamines do not play a direct role in the pathogenesis of TS., (© 2021 The Authors. Clinical Cardiology published by Wiley Periodicals LLC.)
- Published
- 2021
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43. CTA pulmonary artery enlargement in patients with severe aortic stenosis: Prognostic impact after TAVR.
- Author
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Turner VL, Jubran A, Kim JB, Maret E, Moneghetti KJ, Haddad F, Amsallem M, Codari M, Hinostroza V, Mastrodicasa D, Sailer AM, Kobayashi Y, Nishi T, Yeung AC, Watkins AC, Lee AM, Miller DC, Fischbein MP, Fearon WF, Willemink MJ, and Fleischmann D
- Subjects
- Aortic Valve diagnostic imaging, Aortic Valve surgery, Computed Tomography Angiography, Humans, Kaplan-Meier Estimate, Predictive Value of Tests, Prognosis, Pulmonary Artery diagnostic imaging, Retrospective Studies, Risk Factors, Severity of Illness Index, Treatment Outcome, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Transcatheter Aortic Valve Replacement adverse effects
- Abstract
Background: Identifying high-risk patients who will not derive substantial survival benefit from TAVR remains challenging. Pulmonary hypertension is a known predictor of poor outcome in patients undergoing TAVR and correlates strongly with pulmonary artery (PA) enlargement on CTA. We sought to evaluate whether PA enlargement, measured on pre-procedural computed tomography angiography (CTA), is associated with 1-year mortality in patients undergoing TAVR., Methods: We retrospectively included 402 patients undergoing TAVR between July 2012 and March 2016. Clinical parameters, including Society of Thoracic Surgeons (STS) score and right ventricular systolic pressure (RVSP) estimated by transthoracic echocardiography were reviewed. PA dimensions were measured on pre-procedural CTAs. Association between PA enlargement and 1-year mortality was analyzed. Kaplan-Meier and Cox proportional hazards regression analyses were performed., Results: The median follow-up time was 433 (interquartiles 339-797) days. A total of 56/402 (14%) patients died within 1 year after TAVR. Main PA area (area-MPA) was independently associated with 1-year mortality (hazard ratio per standard deviation equal to 2.04 [95%-confidence interval (CI) 1.48-2.76], p < 0.001). Area under the curve (95%-CI) of the clinical multivariable model including STS-score and RVSP increased slightly from 0.67 (0.59-0.75) to 0.72 (0.72-0.89), p = 0.346 by adding area-MPA. Although the AUC increased, differences were not significant (p = 0.346). Kaplan-Meier analysis showed that mortality was significantly higher in patients with a pre-procedural non-indexed area-MPA of ≥7.40 cm
2 compared to patients with a smaller area-MPA (mortality 23% vs. 9%; p < 0.001)., Conclusions: Enlargement of MPA on pre-procedural CTA is independently associated with 1-year mortality after TAVR., Competing Interests: Declaration of competing interest This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors., (Copyright © 2021 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.)- Published
- 2021
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44. Early Comprehensive Cardiovascular Magnetic Resonance Imaging in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries.
- Author
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Sörensson P, Ekenbäck C, Lundin M, Agewall S, Bacsovics Brolin E, Caidahl K, Cederlund K, Collste O, Daniel M, Jensen J, Y-Hassan S, Henareh L, Hofman-Bang C, Lyngå P, Maret E, Sarkar N, Spaak J, Winnberg O, Ugander M, and Tornvall P
- Subjects
- Coronary Angiography, Humans, Magnetic Resonance Imaging, Predictive Value of Tests, Prospective Studies, Coronary Vessels diagnostic imaging, Myocardial Infarction diagnostic imaging
- Abstract
Objectives: The objective of the SMINC-2 (Stockholm Myocardial Infarction With Normal Coronaries 2) study was to determine if more than 70% of patients with myocardial infarction with nonobstructed coronary arteries (MINOCA), investigated early with comprehensive cardiovascular magnetic resonance (CMR), could receive a diagnosis entirely by imaging., Background: The etiology of MINOCA is heterogeneous, including coronary, cardiac, and noncardiac causes. Patients with MINOCA, therefore, represent a diagnostic challenge where CMR is increasingly used., Methods: The SMINC-2 study was a prospective study of 148 patients with MINOCA imaged with 1.5-T CMR with T
1 and extracellular volume mapping early after hospital admission, compared to 150 patients with MINOCA imaged using 1.5-T CMR without mapping techniques from the SMINC-1 study as historic controls., Results: CMR was performed at a median of 3 (SMINC-2) versus 12 (SMINC-1) days after hospital admission. In total, 77% of patients received a diagnosis with CMR imaging in the SMINC-2 study compared to 47% in the SMINC-1 study (p < 0.001). Compared to SMINC-1, CMR in SMINC-2 detected higher proportions of myocarditis (17% vs. 7%; p = 0.01) and takotsubo syndrome (35% vs. 19%; p = 0.002) but similar proportions of myocardial infarction (22% vs. 19%; p = 0.56) and other cardiomyopathies (3% vs. 2%; p = 0.46)., Conclusions: The results of the SMINC-2 study show that 77% of all patients with MINOCA received a diagnosis when imaged early with CMR, including advanced tissue characterization, which was a considerable improvement in comparison to the SMINC-1 study. This supports the use of early CMR imaging as a diagnostic tool in the investigation of patients with MINOCA. (Stockholm Myocardial Infarction With Normal Coronaries [SMINC]-2 Study on Diagnosis Made by Cardiac MRI [SCMINC-2]; NCT02318498)., Competing Interests: Funding Support and Author Disclosures This work was supported by the Swedish research council (grant no. 2013-02190), Stockholm county council (grant no. 20150051, 20170053), and Swedish Heart and Lung Foundation (grant no. 20150612). Peder Sörensson is affiliated with Karolinska University Hospital, which has a research agreement with Siemens Healthineers regarding cardiac magnetic resonance. Dr. Lundin is affiliated with Karolinska University Hospital, which has a research agreement with Siemens Healthineers regarding cardiac magnetic resonance. Dr. Spaak has in the last 3 years received personal fees from AstraZeneca (Cambridge, United Kingdom), Vifor Pharma (Glattbrugg, Switzerland), and NovoNordisk (Bagsværd, Denmark), outside the submitted work. Dr. Ugander is affiliated with Karolinska University Hospital, which has a research agreement with Siemens Healthineers regarding cardiac magnetic resonance. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2021
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45. Comprehensive Cardiovascular Magnetic Resonance Diastolic Dysfunction Grading Shows Very Good Agreement Compared With Echocardiography.
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Ramos JG, Fyrdahl A, Wieslander B, Thalén S, Reiter G, Reiter U, Jin N, Maret E, Eriksson M, Caidahl K, Sörensson P, Sigfridsson A, and Ugander M
- Subjects
- Aged, Diastole, Female, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged, Predictive Value of Tests, Echocardiography, Ventricular Dysfunction, Left
- Abstract
Objectives: The aims of this study were to develop a comprehensive cardiovascular magnetic resonance (CMR) approach to diastolic dysfunction (DD) grading and to evaluate the accuracy of CMR in the diagnosis of DD compared with echocardiography., Background: Left ventricular DD is routinely assessed using echocardiography., Methods: Consecutive clinically referred patients (n = 46; median age 59 years; interquartile range: 46 to 68 years; 33% women) underwent both conventional echocardiography and CMR. CMR diastolic transmitral velocities (E and A) and myocardial tissue velocity (e') were measured during breath-hold using a validated high-temporal resolution radial sector-wise golden-angle velocity-encoded sequence. CMR pulmonary artery pressure was estimated from 4-dimensional flow analysis of blood flow vortex duration in the pulmonary artery. CMR left atrial volume was measured using the biplane long-axis area-length method. Both CMR and echocardiographic data were used to perform blinded grading of DD according to the 2016 joint American and European recommendations., Results: Grading of DD by CMR agreed with that by echocardiography in 43 of 46 cases (93%), of which 9% were normal, 2% indeterminate, 63% grade 1 DD, 4% grade 2 DD, and 15% grade 3 DD. There was a very good categorical agreement, with a weighted Cohen kappa coefficient of 0.857 (95% confidence interval: 0.73 to 1.00; p < 0.001)., Conclusions: A comprehensive CMR protocol for grading DD encompassing diastolic blood and myocardial velocities, estimated pulmonary artery pressure, and left atrial volume showed very good agreement with echocardiography., Competing Interests: Author Disclosures Drs. Wieslander, Ramos, Sigfridsson, and Ugander were supported in part by the Swedish Research Council, the Swedish Heart-Lung Foundation, the Stockholm County Council, and Karolinska Institutet. Drs. Reiter and Jin are employed by Siemens. Dr. Maret was supported by the Swedish Heart-Lung Foundation. Dr. Eriksson was supported by the Swedish Heart-Lung Foundation and the Stockholm County Council. Dr. Caidahl was supported by the Swedish Heart Lung Foundation and the Västra Götaland Region; and is principal investigator for an institutional grant from CarlBennet. Dr. Ugander is principal investigator for an institutional research and development agreement regarding cardiovascular magnetic resonance imaging between Karolinska University Hospital and Siemens. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2020
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46. Impact of right ventricular volumes on the outcomes of TAVR: a volumetric analysis of preprocedural computed tomography.
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Rozenbaum Z, Maret E, Lax L, Shmilovich H, Finkelstein A, Steinvil A, Halkin A, Banai S, Cohen D, Topilsky Y, Berliner S, Fleischmann D, and Aviram G
- Subjects
- Aortic Valve, Aortic Valve Insufficiency diagnostic imaging, Aortic Valve Insufficiency mortality, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis mortality, Humans, Israel epidemiology, Risk Factors, Severity of Illness Index, Treatment Outcome, Angiography, Aortic Valve Insufficiency etiology, Aortic Valve Stenosis surgery, Cardiac-Gated Imaging Techniques, Echocardiography, Heart Ventricles diagnostic imaging, Transcatheter Aortic Valve Replacement methods
- Abstract
Aims: The aim of this study was to assess the prognostic implications of increased right ventricle volume index (RVVI) using cardiac-gated computed tomography angiography (CCTA) data among patients undergoing transcatheter valve replacement (TAVR)., Methods and Results: CCTA of 323 patients who underwent TAVR at Stanford University Medical Center (CA, USA) and Tel Aviv Medical Center (Israel) between 2013 and 2016 was analysed by an automatic four-chamber volumetric software and grouped into quartiles according to RVVI. Higher one-year mortality rates were noted for the upper quartiles - 5%, 4.9%, 8.6%, and 16% (p=0.039), in Q1 <59 ml/m2, Q2 59-69 ml/m2, Q3 69-86 ml/m2, and Q4 >86 ml/m2, respectively. However, the differences were not significant after propensity score adjustments. Sub-analyses of Q1 demonstrated an escalating risk for one-year mortality in concordance to RVVI: HR 2.28, HR 2.76, and HR 4.7, for the upper 25th, 15th, and 5th percentiles, respectively (p<0.05 for all comparisons). After propensity score adjustments for clinical and echocardiographic characteristics, only the upper 5th percentiles (RVVI >120 ml/m2) retained statistical significance (HR 2.82, 95% CI: 1.02-7.78, p=0.045). Notably, 68.7% of patients from this group were considered low-intermediate risk for surgery., Conclusions: Cardiac volumetric data by CCTA performed for procedural planning may help to predict outcome in patients undergoing TAVR.
- Published
- 2020
- Full Text
- View/download PDF
47. Active chest tube clearance after aortic valve surgery did not influence amount residual pericardial fluid after aortic valve replacement in a randomised trial.
- Author
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Malgerud L, Maret E, Reitan C, and Ivert T
- Subjects
- Aged, Drainage adverse effects, Equipment Design, Female, Humans, Male, Middle Aged, Pericardial Effusion diagnostic imaging, Pericardial Effusion etiology, Postoperative Hemorrhage etiology, Prospective Studies, Sweden, Time Factors, Treatment Outcome, Aortic Valve surgery, Chest Tubes, Drainage instrumentation, Heart Valve Prosthesis Implantation adverse effects, Pericardial Effusion prevention & control, Postoperative Hemorrhage prevention & control
- Abstract
Objective. Evaluate if the use of active clearance of chest tubes after aortic valve surgery influenced bleeding and reduced postoperative residual pericardial effusion. Design. Prospective randomised trial comparing PleuraFlow
® 32 F chest tube with FlowGlide™ active clearance to a standard Argyle® 32 F chest tube in 100 patients undergoing aortic valve surgery. Chest tube outputs and pericardial effusion measurements assessed by two-dimensional transthoracic echocardiography were recorded before hospital discharge. Results. Postoperative chest tube outputs per hour did not differ between the two groups. The median chest tube output was 400 mL for patients who had a PleuraFlow® chest tube vs . 490 mL for patients with an Argyle® chest tube ( p = .08). Pericardial effusions ≥ 2 mm were detected in 76% vs. 68% of the patients ( p = .50) and postoperative atrial fibrillation occurred in 42% vs . 34% ( p = .54), respectively. Conclusions. Use of active clearance chest tubes, compared to standard chest tubes after aortic valve surgery did not differ significantly regarding postoperative bleeding or degree of pericardial effusion as measured by echocardiography prior to hospital discharge.- Published
- 2020
- Full Text
- View/download PDF
48. Validation of non-invasive ramp testing for HeartMate 3.
- Author
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Najjar E, Thorvaldsen T, Dalén M, Svenarud P, Hallberg Kristensen A, Eriksson MJ, Maret E, and Lund LH
- Subjects
- Echocardiography, Heart Ventricles diagnostic imaging, Humans, Retrospective Studies, Heart Failure, Heart-Assist Devices
- Abstract
Aims: Ramp testing in the postoperative period can be used to optimize left ventricular assist device (LVAD) speed for optimal left ventricular (LV) unloading. We tested the hypothesis that a non-invasive echocardiographic ramp test post-HeartMate 3 implantation improves LV unloading immediately after and 1-3 months after as compared with before the test. We also tested a secondary hypothesis that speed adjustments during echocardiography-guided ramp testing do not worsen right ventricular (RV) function immediately after and 1-3 months after., Methods and Results: We retrospectively reviewed data from patients who underwent an echocardiographic ramp test. A total of 14 out of 19 patients were clinically stable and were enrolled. Adequate LV unloading was defined as no more than mild mitral regurgitation, and intermittent aortic valve (AV) opening or closed AV, and reduction of left ventricular end-diastolic diameter (LVEDD); and for the follow-up measurement, decreased NT-proBNP. Median (interquartile range) time from implantation to ramp test was 27 (16; 56) days, and median time from ramp test to follow-up echocardiography was 55 (47; 102) days. Median LVAD speed achieved during ramp testing was 5550 (5375; 6025) revolutions per minute (rpm), and median final LVAD speed was 5200 (5000; 5425) rpm. Ramp testing resulted in final LVAD speed increase in 11 (79%) patients and a median net change of 200 (200; 300) rpm. Speed adjustments after ramp testing resulted in improved LVAD unloading that was achieved in additional 3 (21%) patients who were not originally optimized. RV function did not worsen significantly during ramp testing or at final LVAD speed., Conclusions: The echocardiographic ramp test allowed LVAD speed adjustment and optimization and improved LV unloading during ramp testing and at final speed with no evidence of worsening of RV function., (© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.)
- Published
- 2020
- Full Text
- View/download PDF
49. Stationary tissue background correction increases the precision of clinical evaluation of intra-cardiac shunts by cardiovascular magnetic resonance.
- Author
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Nickander J, Lundin M, Abdula G, Jenner J, Maret E, Sörensson P, Heiberg E, Sigfridsson A, and Ugander M
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Retrospective Studies, Sensitivity and Specificity, Aorta physiopathology, Blood Flow Velocity, Cardiovascular Diseases diagnosis, Cardiovascular Diseases physiopathology, Magnetic Resonance Imaging methods, Pulmonary Artery innervation, Pulmonary Artery physiopathology, Pulmonary Circulation
- Abstract
We aimed to evaluate the clinical utility of stationary tissue background phase correction for affecting precision in the measurement of Qp/Qs by cardiovascular magnetic resonance (CMR). We enrolled consecutive patients (n = 91) referred for CMR at 1.5T without suspicion of cardiac shunt, and patients (n = 10) with verified cardiac shunts in this retrospective study. All patients underwent phase contrast flow quantification in the ascending aorta and pulmonary trunk. Flow was quantified using two semi-automatic software platforms (SyngoVia VA30, Vendor 1; Segment 2.0R4534, Vendor 2). Measurements were performed both uncorrected and corrected for linear (Vendor 1 and Vendor 2) or quadratic (Vendor 2) background phase. The proportion of patients outside the normal range of Qp/Qs was compared using the McNemar's test. Compared to uncorrected measurements, there were fewer patients with a Qp/Qs outside the normal range following linear correction using Vendor 1 (10% vs 18%, p < 0.001), and Vendor 2 (10% vs 18%, p < 0.001), and following quadratic correction using Vendor 2 (7% vs 18%, p < 0.001). No patient with known shunt was reclassified as normal following stationary background correction. Therefore, we conclude that stationary tissue background correction reduces the number of patients with a Qp/Qs ratio outside the normal range in a consecutive clinical population, while simultaneously not reclassifying any patient with known cardiac shunts as having a normal Qp/Qs. Stationary tissue background correction may be used in clinical patients to increase diagnostic precision.
- Published
- 2020
- Full Text
- View/download PDF
50. Cardiovascular magnetic resonance 4D flow analysis has a higher diagnostic yield than Doppler echocardiography for detecting increased pulmonary artery pressure.
- Author
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Ramos JG, Fyrdahl A, Wieslander B, Reiter G, Reiter U, Jin N, Maret E, Eriksson M, Caidahl K, Sörensson P, Sigfridsson A, and Ugander M
- Subjects
- Aged, Female, Humans, Imaging, Three-Dimensional, Male, Middle Aged, Prospective Studies, Sensitivity and Specificity, Echocardiography, Doppler methods, Hypertension, Pulmonary diagnostic imaging, Magnetic Resonance Imaging, Cine methods
- Abstract
Background: Pulmonary hypertension is definitively diagnosed by the measurement of mean pulmonary artery (PA) pressure (mPAP) using right heart catheterization. Cardiovascular magnetic resonance (CMR) four-dimensional (4D) flow analysis can estimate mPAP from blood flow vortex duration in the PA, with excellent results. Moreover, the peak systolic tricuspid regurgitation (TR) pressure gradient (TRPG) measured by Doppler echocardiography is commonly used in clinical routine to estimate systolic PA pressure. This study aimed to compare CMR and echocardiography with regards to quantitative and categorical agreement, and diagnostic yield for detecting increased PA pressure., Methods: Consecutive clinically referred patients (n = 60, median [interquartile range] age 60 [48-68] years, 33% female) underwent echocardiography and CMR at 1.5 T (n = 43) or 3 T (n = 17). PA vortex duration was used to estimate mPAP using a commercially available time-resolved multiple 2D slice phase contrast three-directional velocity encoded sequence covering the main PA. Transthoracic Doppler echocardiography was performed to measure TR and derive TRPG. Diagnostic yield was defined as the fraction of cases in which CMR or echocardiography detected an increased PA pressure, defined as vortex duration ≥15% of the cardiac cycle (mPAP ≥25 mmHg) or TR velocity > 2.8 m/s (TRPG > 31 mmHg)., Results: Both CMR and echocardiography showed normal PA pressure in 39/60 (65%) patients and increased PA pressure in 9/60 (15%) patients, overall agreement in 48/60 (80%) patients, kappa 0.49 (95% confidence interval 0.27-0.71). CMR had a higher diagnostic yield for detecting increased PA pressure compared to echocardiography (21/60 (35%) vs 9/60 (15%), p < 0.001). In cases with both an observable PA vortex and measurable TR velocity (34/60, 56%), TRPG was correlated with mPAP (R
2 = 0.65, p < 0.001)., Conclusions: There is good quantitative and fair categorical agreement between estimated mPAP from CMR and TRPG from echocardiography. CMR has higher diagnostic yield for detecting increased PA pressure compared to echocardiography, potentially due to a lower sensitivity of echocardiography in detecting increased PA pressure compared to CMR, related to limitations in the ability to adequately visualize and measure the TR jet by echocardiography. Future comparison between echocardiography, CMR and invasive measurements are justified to definitively confirm these findings.- Published
- 2020
- Full Text
- View/download PDF
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