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2. ICU-acquired hypernatremia: Prevalence, patient characteristics, trajectory, risk factors, and outcomes

Author

Ramanan, Mahesh, Marella, Prashanti, Young, Patrick, McIlroy, Philippa, Nash, Ben, McCullough, James, Denny, Kerina J., Tallott, Mandy, Marshall, Andrea, Moore, David, Sane, Sunil, Kumar, Aashish, Morrison, Lynette, Dipplesman, Pam, Taylor, Jennifer, Luke, Stephen, Paasilahti, Anni, Asimus, Ray, White, Kyle, Meyer, Jason, Hurford, Rod, Harward, Meg, Walsham, James, Bhadange, Neeraj, Stevens, Wayne, Plumpton, Kevin, Raman, Sainath, Barlow, Andrew, Tabah, Alexis, Pollock, Hamish, Baker, Stuart, Jacobs, Kylie, Attokaran, Antony G., Austin, David, Poggenpoel, Jacobus, Reoch, Josephine, Laupland, Kevin B., Edwards, Felicity, Evans, Tess, Dhanani, Jayesh, Kirrane, Marianne, Clement, Pierre, Karamujic, Nermin, Lister, Paula, Masurkar, Vikram, Murray, Lauren, Brailsford, Jane, Erbacher, Todd, Shekar, Kiran, Lavana, Jayshree, Cornmell, George, Senthuran, Siva, Whebell, Stephen, Gatton, Michelle, Keogh, Sam, Nasser, Ahmad, Chaba, Anis, Garrett, Peter, Bellomo, Rinaldo, and White, Kyle C.

Published
2024
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3. Timing of adjunctive vasopressin initiation for septic shock patients and hospital mortality: A multicentre observational study

Author

Ramanan, Mahesh, Marella, Prashanti, Young, Patrick, McIlroy, Pip, Nash, Ben, McCullough, James, Denny, Kerina J., Tallott, Mandy, Marshall, Andrea, Moore, David, White, Hayden, Sane, Sunil, Kumar, Aashish, Morrison, Lynette, Dipplesman, Pam, Taylor, Jennifer, Luke, Stephen, Paasilahti, Anni, Asimus, Ray, White, Kyle, Meyer, Jason, Hurford, Rod, Harward, Meg, Walsham, James, Bhadange, Neeraj, Stevens, Wayne, Plumpton, Kevin, Raman, Sainath, Barlow, Andrew, Tabah, Alexis, Pollock, Hamish, Baker, Stuart, Jacobs, Kylie, Attokaran, Antony G., Austin, David, Poggenpoel, Jacobus, Reoch, Josephine, Laupland, Kevin B., Edwards, Felicity, Evans, Tess, Dhanani, Jayesh, Kirrane, Marianne, Clement, Pierre, Karamujic, Nermin, Lister, Paula, Masurkar, Vikram, Garrett, Peter, Murray, Lauren, Brailsford, Jane, Erbacher, Todd, Shekar, Kiran, Lavana, Jayshree, Cornmell, George, Senthuran, Siva, Whebell, Stephen, Gatton, Michelle, Andrews, Robert, Keogh, Sam, White, Kyle C., Costa-Pinto, Rahul, Chaba, Anis, McIlroy, Philippa, Udy, Andrew, Eastwood, Glenn, and Bellomo, Rinaldo

Published
2024
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4. Epidemiology of hypophosphatemia in critical illness: A multicentre, retrospective cohort study

Author

Ramanan, Mahesh, Marella, Prashanti, Young, Patrick, McIlroy, Pip, Nash, Ben, McCullough, James, Denny, Kerina J, Tallott, Mandy, Marshall, Andrea, Moore, David, White, Hayden, Sane, Sunil, Kumar, Aashish, Morrison, Lynette, Dipplesman, Pam, Taylor, Jennifer, Luke, Stephen, Paasilahti, Anni, Asimus, Ray, White, Kyle, Meyer, Jason, Hurford, Rod, Haward, Meg, Walsham, James, Bhadange, Neeraj, Stevens, Wayne, Plumpton, Kevin, Raman, Sainath, Barlow, Andrew, Tabah, Alexis, Pollock, Hamish, Baker, Stuart, Jacobs, Kylie, Attokaran, Antony G., Austin, David, Poggenpoel, Jacobus, Reoch, Josephine, Laupland, Kevin B., Edwards, Felicity, Evans, Tess, Dhanani, Jayesh, Kirrane, Marianne, Clement, Pierre, Karamujic, Nermin, Lister, Paula, Masurkar, Vikram, Murray, Lauren, Brailsford, Jane, Erbacher, Todd, Shekar, Kiran, Lavana, Jayshree, Cornmell, George, Senthuran, Siva, Whebell, Stephen, Gatton, Michelle, Tyack, Zephanie, Andrews, Robert, Keogh, Sam, Attokaran, Antony George, White, Kyle C, Doola, Ra'eesa, McIlroy, Philippa, Garrett, Peter, McCullough, James PA, and Laupland, Kevin B

Published
2024
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5. How often are infusion sets for central venous catheters changed in Australian and New Zealand Intensive Care Units? A point prevalence survey

Author

Hammond, Naomi, Freeman-Sanderson, Amy, Ganu, Subodh, Howe, Belinda, Litton, Ed, Mackle, Diane, Saxena, Manoj, Seppelt, Ian, Towns, Miriam, Yarad, Elizabeth, Knowles, Serena, Gao, Annie, Li, Yang, Myburgh, John, Nangla, Conrad, Butt, Fatima, Duke, Graeme, Hunter, Stephanie, Evans, Julie, Parker, Dianne, Loughnan, Clare, Thomas, Blessy, Gilder, Eileen, Robertson, Melissa, McMahon, Ellie, Ali, Farisha, Cowdrey, Keri-Anne, McArthur, Colin, Chen, Yan, Simmonds, Catherine, McConnochie, Rachael, O'Connor, Caroline, El-Khawas, Khaled, Hill, Dianne, Cattigan, Claire, Horton, Michelle, Trickey, Jemma, Knott, Cameron, Smith, Julie, Boschert, Catherine, Sara, Treena, Nand, Kiran, Ramanan, Mahesh, Marella, Prashanti, Affleck, Julia, Simpson, Shannon, Ellem, Katrina, McKenna, Toni, Nourse, Mary, Leung, Kristine, Edmunds, Tash, McDonald, Bree, Mehrtens, Jan, Cross, Rosalba, Wong, Helen, Twardowski, Pawel, France, Dawn, Hanlon, Gabrielle, Barrett, Jonathan, Palermo, Annamaria, Pellicano, Susan, Eroglu, Ege, Bihari, Shailesh, Brown, Julia, Grear, Laura, Jin, Xia, French, Craig, Bates, Samantha, Marshall, Fiona, McEldrew, Rebecca, McCullough, James, Tallott, Mandy, Gough, Maimoonbe, Nalos, Marek, Younger, Laura, Krishnamurphy, Ravi, Trent, Louise, How, Janet, Stuart, Anne, Chadwick, Llesley, Bhadange, Neeraj, Tyler, Steven, Sosnowski, Kellie, Morrison, Lynette, Sutton, Joanne, Soar, Natalie, Lee, David, Doyle, Marina, Jongebloed, Katherine, Finnis, Mackenzie, Wilson, Jane, Williams, Tony, Song, Rima, Lai, Vivian, Girijadevi, Dinu, Habraken, Hannah, Browne, Alex, Koelle, Jette, McNab, Charlotte, Masters, Kristy, Gresham, Rebecca, Lowrey, Julie, Whitehead, Christina, Liang, Janet, Harward, Meg, Jones, Cassie, Peake, Sandra, Williams, Tricia, Kurenda, Catherine, Tabah, Alexis, Duroux, Maree, Warhurst, Timothy, Ratcliffe, Megan, Pollock, Hamish, Baker, Stuart, Sonawane, Ravikiran, O'Connor, Stephanie, Brown, Nerissa, Glasby, Kathleen, Rivett, Justine, Campbell, Lewis, Tabuzo, Vera, Smyth, Kirsty, Bass, Frances, O'Connor, Anne, Leonard, Anton, Waterson, Sharon, Coles, Jennifer, Buhr, Heidi, Newman, Duncan, Boorawong, Piyaporn, Bregolin, Vanessa, Yun, Ji-Hyun, Anstey, Matthew, Rock, Lara, Endemann, Anthadene, Lo, Wei, Ferrier, Janet, Reynolds, Claire, Santamaria, John, Holmes, Jennifer, Beca, John, Sherring, Claire, Garrett, Peter, Murray, Lauren, Brailsford, Jane, Browne, Troy, Goodson, Jennifer, Udy, Andrew, Young, Meredith, Board, Jasmin, McCracken, Phoebe, Martin, Emma-Leah, Martynoga, Robert, Butler, Amelia, Trask, Kara, Olatunji, Shaanti, Cruz, Rhoze Sol, Cruz, Raulle Sol, Navarra, Leanlove, Delaney, Kirsha, Lesona, Eden, Young, Chelsea, Spring, Amelia, Aguilar, April, Young, Paul, Law, Erin, Anstey, Matthew H., Maxwell, Nicky, Rickard, Claire M., Hammond, Naomi E., and McGain, Forbes

Published
2024
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6. Predicting a strongly positive fluid balance in critically ill patients with acute kidney injury: A multicentre, international study

Author

Ramanan, Mahesh, Marella, Prashanti, Young, Patrick, McIlroy, Phillipa, Nash, Ben, McCullough, James, Denny, Kerina J., Tallott, Mandy, Marshall, Andrea, Moore, David, White, Hayden, Sane, Sunil, Kumar, Aashish, Morrison, Lynette, Dipplesman, Pam, Taylor, Jennifer, Luke, Stephen, Paasilahti, Anni, Asimus, Ray, White, Kyle, Meyer, Jason, Hurford, Rod, Harward, Meg, Walsham, James, Bhadange, Neeraj, Stevens, Wayne, Tabah, Alexis, Pollock, Hamish, Baker, Stuart, Jacobs, Kylie, Attokaran, Antony G., Poggenpoel, Jacobus, Reoch, Josephine, Laupland, Kevin B., Edwards, Felicity, Evans, Tess, Dhanani, Jayesh, Clement, Pierre, Karamujic, Nermin, Lister, Paula, Masurkar, Vikram, Murray, Lauren, Brailsford, Jane, Erbacher, Todd, Shekar, Kiran, Lavana, Jayshree, Cornmell, George, Senthuran, Siva, Whebell, Stephen, Gatton, Michelle, Tyack, Zephanie, Keogh, Sam, White, Kyle C., Bellomo, Rinaldo, Gatton, Michelle L., Ostermann, Marlies, McIlroy, Philipa, Garrett, Peter, Sanderson, Barnaby, and Serpa-Neto, Ary

Published
2025
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8. How much do we throw away in the intensive care unit? An observational point prevalence study of Australian and New Zealand ICUs

Author

Hammond, Naomi, Knowles, Serena, Freeman-Sanderson, Amy, Ganu, Subodh, Howe, Belinda, Litton, Ed, Mackle, Diane, Saxena, Manoj, Seppelt, Ian, Towns, Miriam, Yarad, Elizabeth, Hammond, Gao, Annie, Li, Yang, Myburgh, John, Nangla, Conrad, Butt, Fatima, Duke, Graeme, Hunter, Stephanie, Evans, Julie, Parker, Dianne, Loughnan, Clare, Thomas, Blessy, Gilder, Eileen, Robertson, Melissa, McMahon, Ellie, Ali, Farisha, Cowdrey, Keri-Anne, McArthur, Colin, Chen, Yan, Simmonds, Catherine, McConnochie, Rachael, O'Connor, Caroline, El-Khawas, Khaled, Hill, Dianne, Cattigan, Claire, Horton, Michelle, Trickey, Jemma, Knott, Cameron, Smith, Julie, Boschert, Catherine, Sara, Treena, Nand, Kiran, Ramanan, Mahesh, Marella, Prashanti, Affleck, Julia, Simpson, Shannon, Ellem, Katrina, McKenna, Toni, Nourse, Mary, Leung, Kristine, Edmunds, Tash, McDonald, Bree, Mehrtens, Jan, Cross, Rosalba, Wong, Helen, Twardowski, Pawel, France, Dawn, Hanlon, Gabrielle, Barrett, Jonathan, Palermo, Annamaria, Pellicano, Susan, Eroglu, Ege, Bihari, Shailesh, Brown, Julia, Grear, Laura, Jin, Xia, French, Craig, Bates, Samantha, Marshall, Fiona, McEldrew, Rebecca, McCullough, James, Tallott, Mandy, Gough, Maimoonbe, Nalos, Marek, Younger, Laura, Krishnamurphy, Ravi, Trent, Louise, How, Janet, Stuart, Anne, Chadwick, Llesley, Bhadange, Neeraj, Tyler, Steven, Sosnowski, Kellie, Morrison, Lynette, Sutton, Joanne, Soar, Natalie, Lee, David, Doyle, Marina, Jongebloed, Katherine, Finnis, Mackenzie, Wilson, Jane, Williams, Tony, Song, Rima, Lai, Vivian, Girijadevi, Dinu, Habraken, Hannah, Browne, Alex, Koelle, Jette, McNab, Charlotte, Masters, Kristy, Gresham, Rebecca, Lowrey, Julie, Whitehead, Christina, Liang, Janet, Harward, Meg, Jones, Cassie, Peake, Sandra, Williams, Tricia, Kurenda, Catherine, Tabah, Alexis, Duroux, Maree, Warhurst, Timothy, Ratcliffe, Megan, Pollock, Hamish, Baker, Stuart, Sonawane, Ravikiran, O'Connor, Stephanie, Brown, Nerissa, Glasby, Kathleen, Rivett, Justine, Campbell, Lewis, Tabuzo, Vera, Smyth, Kirsty, Bass, Frances, O'Connor, Anne, Leonard, Anton, Waterson, Sharon, Coles, Jennifer, Buhr, Heidi, Newman, Duncan, Boorawong, Piyaporn, Bregolin, Vanessa, Yun, Ji-Hyun, Anstey, Matthew, Rock, Lara, Endemann, Anthadene, Lo, Wei, Ferrier, Janet, Reynolds, Claire, Santamaria, John, Holmes, Jennifer, Beca, John, Sherring, Claire, Garrett, Peter, Murray, Lauren, Brailsford, Jane, Browne, Troy, Goodson, Jennifer, Udy, Andrew, Young, Meredith, Board, Jasmin, McCracken, Phoebe, Martin, Emma-Leah, Martynoga, Robert, Butler, Amelia, Trask, Kara, Olatunji, Shaanti, Cruz, Rhoze Sol, Cruz, Raulle Sol, Navarra, Leanlove, Delaney, Kirsha, Lesona, Eden, Young, Chelsea, Spring, Amelia, Aguilar, April, Young, Paul, Law, Erin, Anstey, Matthew H., Bhonagiri, Deepak, Hammond, Naomi E., and McGain, Forbes

Published
2023
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10. Sepsis‐associated acute kidney injury in patients with chronic kidney disease: Patient characteristics, prevalence, timing, trajectory, treatment and associated outcomes.

Author

White, Kyle C., Bellomo, Rinaldo, Tabah, Alexis, Attokaran, Antony G., White, Hayden, McCullough, James, Shekar, Kiran, Ramanan, Mahesh, Garrett, Peter, McIlroy, Philippa, Senthuran, Siva, Luke, Stephen, Serpa‐Neto, Ary, Larsen, Tom, Laupland, Kevin B., Marella, Prashanti, Young, Patrick, McIlroy, Phillipa, Nash, Ben, and Denny, Kerina J

Subjects
APACHE (Disease classification system), ACUTE kidney failure, CHRONIC kidney failure, INTENSIVE care units, RENAL replacement therapy
Abstract

Aim: The features and outcomes of sepsis‐associated acute kidney injury (SA‐AKI) may be affected by chronic kidney disease (CKD). Accordingly, we aimed to compare SA‐AKI in patients with or without CKD. Methods: Retrospective cohort study in 12 intensive care units (ICU). We studied the prevalence, patient characteristics, timing, trajectory, treatment and outcomes of SA‐AKI with and without CKD. Results: Of 84 240 admissions, 7255 (8.6%) involved patients with CKD. SA‐AKI was more common in patients with CKD (21% vs 14%; p <.001). CKD patients were older (70 vs. 60 years; p <.001), had a higher median Charlson co‐morbidity index (5 vs. 3; p <.001) and acute physiology and chronic health evaluation (APACHE) III score (78 vs. 60; p <.001) and were more likely to receive renal replacement therapy (RRT) (25% vs. 17%; p <.001). They had less complete return to baseline function at ICU discharge (48% vs. 60%; p <.001), higher major adverse kidney events at day 30 (MAKE‐30) (38% vs. 27%; p <.001), and higher hospital and 90‐day mortality (21% vs. 13%; p <.001, and 27% vs. 16%; p <.001, respectively). After adjustment for patient characteristics and severity of illness, however, CKD was not an independent risk factor for increased 90‐day mortality (OR 0.88; 95% CI 0.76–1.02; p =.08) or MAKE‐30 (OR 0.98; 95% CI 0.80–1.09; p =.4). Conclusion: SA‐AKI is more common in patients with CKD. Such patients are older, more co‐morbid, have higher disease severity, receive different ICU therapies and have different trajectories of renal recovery and greater unadjusted mortality. However, after adjustment day‐90 mortality and MAKE‐30 risk were not increased by CKD. Summary at a Glance: It was previously unknown how sepsis‐associated acute kidney injury affects patients with chronic kidney disease. In a study involving a large group of critically ill patients, it was found that those with CKD were more likely to develop the condition, were older and had more health problems, received different treatments, and had a higher unadjusted mortality rate. However, after adjusting for other factors, there was no significant increase in mortality. [ABSTRACT FROM AUTHOR]

Published
2024
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12. ICU-acquired hypernatremia: Prevalence, patient characteristics, trajectory, risk factors, and outcomes

Author

Nasser, Ahmad, Chaba, Anis, Laupland, Kevin B., Ramanan, Mahesh, Tabah, Alexis, Attokaran, Antony G., Kumar, Aashish, McCullough, James, Shekar, Kiran, Garrett, Peter, McIlroy, Philippa, Luke, Stephen, Senthuran, Siva, Bellomo, Rinaldo, White, Kyle C., Ramanan, Mahesh, Marella, Prashanti, Young, Patrick, McIlroy, Philippa, Nash, Ben, McCullough, James, Denny, Kerina J., Tallott, Mandy, Marshall, Andrea, Moore, David, Sane, Sunil, Kumar, Aashish, Morrison, Lynette, Dipplesman, Pam, Taylor, Jennifer, Luke, Stephen, Paasilahti, Anni, Asimus, Ray, Taylor, Jennifer, White, Kyle, Meyer, Jason, Hurford, Rod, Harward, Meg, Walsham, James, Bhadange, Neeraj, Stevens, Wayne, Plumpton, Kevin, Raman, Sainath, Barlow, Andrew, Tabah, Alexis, Pollock, Hamish, Baker, Stuart, Jacobs, Kylie, Attokaran, Antony G., Austin, David, Poggenpoel, Jacobus, Reoch, Josephine, Laupland, Kevin B., Edwards, Felicity, Evans, Tess, Dhanani, Jayesh, Kirrane, Marianne, Clement, Pierre, Karamujic, Nermin, Lister, Paula, Masurkar, Vikram, Murray, Lauren, Brailsford, Jane, Erbacher, Todd, Shekar, Kiran, Lavana, Jayshree, Cornmell, George, Senthuran, Siva, Whebell, Stephen, Gatton, Michelle, and Keogh, Sam

Abstract

Knowledge of intensive care unit (ICU) acquired hypernatremia (ICU-AH) has been hampered by the absence of granular data and confounded by variable definitions and inclusion criteria.

Published
2024
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13. Timing of adjunctive vasopressin initiation for septic shock patients and hospital mortality: A multicentre observational study

Author

White, Kyle C., Costa-Pinto, Rahul, Chaba, Anis, McIlroy, Philippa, Senthuran, Siva, Luke, Stephen, Attokaran, Antony G., Garrett, Peter, Ramanan, Mahesh, Tabah, Alexis, Shekar, Kiran, Laupland, Kevin B., White, Hayden, McCullough, James, Udy, Andrew, Eastwood, Glenn, Bellomo, Rinaldo, Ramanan, Mahesh, Marella, Prashanti, Young, Patrick, McIlroy, Pip, Nash, Ben, McCullough, James, Denny, Kerina J., Tallott, Mandy, Marshall, Andrea, Moore, David, White, Hayden, Sane, Sunil, Kumar, Aashish, Morrison, Lynette, Dipplesman, Pam, Taylor, Jennifer, Luke, Stephen, Paasilahti, Anni, Asimus, Ray, White, Kyle, Meyer, Jason, Hurford, Rod, Harward, Meg, Walsham, James, Bhadange, Neeraj, Stevens, Wayne, Plumpton, Kevin, Raman, Sainath, Barlow, Andrew, Tabah, Alexis, Pollock, Hamish, Baker, Stuart, Jacobs, Kylie, Attokaran, Antony G., Austin, David, Poggenpoel, Jacobus, Reoch, Josephine, Laupland, Kevin B., Edwards, Felicity, Evans, Tess, Dhanani, Jayesh, Kirrane, Marianne, Clement, Pierre, Karamujic, Nermin, Lister, Paula, Masurkar, Vikram, Garrett, Peter, Murray, Lauren, Brailsford, Jane, Erbacher, Todd, Shekar, Kiran, Lavana, Jayshree, Cornmell, George, Senthuran, Siva, Whebell, Stephen, Gatton, Michelle, Andrews, Robert, and Keogh, Sam

Abstract

The optimal timing of vasopressin initiation as an adjunctive vasopressor remains unclear. We aimed to study the association between the timing of vasopressin commencement, pre-specified physiological parameters, and hospital mortality.

Published
2024
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14. How often are infusion sets for central venous catheters changed in Australian and New Zealand Intensive Care Units? A point prevalence survey

Author

Anstey, Matthew H., primary, Maxwell, Nicky, additional, Rickard, Claire M., additional, Hammond, Naomi E., additional, Knowles, Serena, additional, McGain, Forbes, additional, Hammond, Naomi, additional, Freeman-Sanderson, Amy, additional, Ganu, Subodh, additional, Howe, Belinda, additional, Litton, Ed, additional, Mackle, Diane, additional, Saxena, Manoj, additional, Seppelt, Ian, additional, Towns, Miriam, additional, Yarad, Elizabeth, additional, Gao, Annie, additional, Li, Yang, additional, Myburgh, John, additional, Nangla, Conrad, additional, Butt, Fatima, additional, Duke, Graeme, additional, Hunter, Stephanie, additional, Evans, Julie, additional, Parker, Dianne, additional, Loughnan, Clare, additional, Thomas, Blessy, additional, Gilder, Eileen, additional, Robertson, Melissa, additional, McMahon, Ellie, additional, Ali, Farisha, additional, Cowdrey, Keri-Anne, additional, McArthur, Colin, additional, Chen, Yan, additional, Simmonds, Catherine, additional, McConnochie, Rachael, additional, O'Connor, Caroline, additional, El-Khawas, Khaled, additional, Hill, Dianne, additional, Cattigan, Claire, additional, Horton, Michelle, additional, Trickey, Jemma, additional, Knott, Cameron, additional, Smith, Julie, additional, Boschert, Catherine, additional, Sara, Treena, additional, Nand, Kiran, additional, Ramanan, Mahesh, additional, Marella, Prashanti, additional, Affleck, Julia, additional, Simpson, Shannon, additional, Ellem, Katrina, additional, McKenna, Toni, additional, Nourse, Mary, additional, Leung, Kristine, additional, Edmunds, Tash, additional, McDonald, Bree, additional, Mehrtens, Jan, additional, Cross, Rosalba, additional, Wong, Helen, additional, Twardowski, Pawel, additional, France, Dawn, additional, Hanlon, Gabrielle, additional, Barrett, Jonathan, additional, Palermo, Annamaria, additional, Pellicano, Susan, additional, Eroglu, Ege, additional, Bihari, Shailesh, additional, Brown, Julia, additional, Grear, Laura, additional, Jin, Xia, additional, French, Craig, additional, Bates, Samantha, additional, Marshall, Fiona, additional, McEldrew, Rebecca, additional, McCullough, James, additional, Tallott, Mandy, additional, Gough, Maimoonbe, additional, Nalos, Marek, additional, Younger, Laura, additional, Krishnamurphy, Ravi, additional, Trent, Louise, additional, How, Janet, additional, Stuart, Anne, additional, Chadwick, Llesley, additional, Bhadange, Neeraj, additional, Tyler, Steven, additional, Sosnowski, Kellie, additional, Morrison, Lynette, additional, Sutton, Joanne, additional, Soar, Natalie, additional, Lee, David, additional, Doyle, Marina, additional, Jongebloed, Katherine, additional, Finnis, Mackenzie, additional, Wilson, Jane, additional, Williams, Tony, additional, Song, Rima, additional, Lai, Vivian, additional, Girijadevi, Dinu, additional, Habraken, Hannah, additional, Browne, Alex, additional, Koelle, Jette, additional, McNab, Charlotte, additional, Masters, Kristy, additional, Gresham, Rebecca, additional, Lowrey, Julie, additional, Whitehead, Christina, additional, Liang, Janet, additional, Harward, Meg, additional, Jones, Cassie, additional, Peake, Sandra, additional, Williams, Tricia, additional, Kurenda, Catherine, additional, Tabah, Alexis, additional, Duroux, Maree, additional, Warhurst, Timothy, additional, Ratcliffe, Megan, additional, Pollock, Hamish, additional, Baker, Stuart, additional, Sonawane, Ravikiran, additional, O'Connor, Stephanie, additional, Brown, Nerissa, additional, Glasby, Kathleen, additional, Rivett, Justine, additional, Campbell, Lewis, additional, Tabuzo, Vera, additional, Smyth, Kirsty, additional, Bass, Frances, additional, O'Connor, Anne, additional, Leonard, Anton, additional, Waterson, Sharon, additional, Coles, Jennifer, additional, Buhr, Heidi, additional, Newman, Duncan, additional, Boorawong, Piyaporn, additional, Bregolin, Vanessa, additional, Yun, Ji-Hyun, additional, Anstey, Matthew, additional, Rock, Lara, additional, Endemann, Anthadene, additional, Lo, Wei, additional, Ferrier, Janet, additional, Reynolds, Claire, additional, Santamaria, John, additional, Holmes, Jennifer, additional, Beca, John, additional, Sherring, Claire, additional, Garrett, Peter, additional, Murray, Lauren, additional, Brailsford, Jane, additional, Browne, Troy, additional, Goodson, Jennifer, additional, Udy, Andrew, additional, Young, Meredith, additional, Board, Jasmin, additional, McCracken, Phoebe, additional, Martin, Emma-Leah, additional, Martynoga, Robert, additional, Butler, Amelia, additional, Trask, Kara, additional, Olatunji, Shaanti, additional, Cruz, Rhoze Sol, additional, Cruz, Raulle Sol, additional, Navarra, Leanlove, additional, Delaney, Kirsha, additional, Lesona, Eden, additional, Young, Chelsea, additional, Spring, Amelia, additional, Aguilar, April, additional, Young, Paul, additional, and Law, Erin, additional

Published
2024
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15. Associations between Late Lactate Clearance and Clinical Outcomes in Adults with Hyperlactataemia in the Setting of Diabetic Ketoacidosis.

Author

Kumar, Aashish, Anstey, Christopher, Doola, Ra'eesa, Mcllroy, Philippa, Whebell, Stephen, Shekar, Kiran, Attokaran, Antony, Marella, Prashanti, White, Kyle, Luke, Stephen, Tabah, Alexis, Laupland, Kevin, and Ramanan, Mahesh

Subjects
APACHE (Disease classification system), DIABETIC acidosis, LENGTH of stay in hospitals, INTENSIVE care units, HYPERLACTATEMIA
Abstract

Objective: This study aimed to determine the associations between lactate clearance in hyperlactataemic patients with diabetic ketoacidosis (DKA) and intensive care unit (ICU), hospital length of stay (LOS), and case-fatality. Methods: A retrospective, multicentre, cohort study of adult patients admitted to ICU with hyperlactataemia and a primary diagnosis of DKA from twelve sites in Queensland, Australia was conducted utilising pre-existing datasets that were linked for research purposes. The patients were divided into early and late lactate clearance groups; the early lactate clearance group included patients whose lactate returned to <2.0 mmol/L within 12 h, and the remainder were classified as late lactate clearance group. Results: The final dataset included 511 patients, 427 in the early lactate clearance group and 84 in the late lactate clearance group. Late lactate clearance was associated with increasing ICU LOS (β = +15.82, 95% CI +0.05 to +31.59, p < 0.049), increasing hospital LOS (β = +7.24, 95% CI +0.11 to 14.37, p = 0.048) and increasing Acute Physiology and Chronic Health Evaluation(APACHE) III score (ICU LOS outcome variable β = +1.05, 95% CI +0.88 to +1.22, p < 0.001; hospital LOS outcome variable β = +3.40, 95% CI +2.22 to 4.57, p < 0.001). Hospital case-fatality was not significantly different (2.2% in the early clearance group vs. 1.7% in the late clearance group, p = 0.496). Conclusions: In hyperlactataemic patients with DKA, late lactate clearance was associated with a statistically significant increase in both ICU and hospital LOS, though the clinical significance in both is minor. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Sepsis-associated acute kidney injury in the intensive care unit: incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes. A multicenter, observational study.

Author

White, Kyle C., Serpa-Neto, Ary, Hurford, Rod, Clement, Pierre, Laupland, Kevin B., See, Emily, McCullough, James, White, Hayden, Shekar, Kiran, Tabah, Alexis, Ramanan, Mahesh, Garrett, Peter, Attokaran, Antony G., Luke, Stephen, Senthuran, Siva, McIlroy, Philippa, Bellomo, Rinaldo, Marella, Prashanti, Young, Patrick, and McIlroy, Pip

Subjects
ACUTE kidney failure, INTENSIVE care units, RENAL replacement therapy, HOSPITAL mortality, SCIENTIFIC observation
Abstract

Purpose: The Acute Disease Quality Initiative (ADQI) Workgroup recently released a consensus definition of sepsis-associated acute kidney injury (SA-AKI), combining Sepsis-3 and Kidney Disease Improving Global Outcomes (KDIGO) AKI criteria. This study aims to describe the epidemiology of SA-AKI. Methods: This is a retrospective cohort study carried out in 12 intensive care units (ICUs) from 2015 to 2021. We studied the incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes of SA-AKI based on the ADQI definition. Results: Out of 84,528 admissions, 13,451 met the SA-AKI criteria with its incidence peaking at 18% in 2021. SA-AKI patients were typically admitted from home via the emergency department (ED) with a median time to SA-AKI diagnosis of 1 day (interquartile range (IQR) 1–1) from ICU admission. At diagnosis, most SA-AKI patients (54%) had a stage 1 AKI, mostly due to the low urinary output (UO) criterion only (65%). Compared to diagnosis by creatinine alone, or by both UO and creatinine criteria, patients diagnosed by UO alone had lower renal replacement therapy (RRT) requirements (2.8% vs 18% vs 50%; p < 0.001), which was consistent across all stages of AKI. SA-AKI hospital mortality was 18% and SA-AKI was independently associated with increased mortality. In SA-AKI, diagnosis by low UO only, compared to creatinine alone or to both UO and creatinine criteria, carried an odds ratio of 0.34 (95% confidence interval (CI) 0.32–0.36) for mortality. Conclusion: SA-AKI occurs in 1 in 6 ICU patients, is diagnosed on day 1 and carries significant morbidity and mortality risk with patients mostly admitted from home via the ED. However, most SA-AKI is stage 1 and mostly due to low UO, which carries much lower risk than diagnosis by other criteria. [ABSTRACT FROM AUTHOR]

Published
2023
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18. How much do we throw away in the intensive care unit? An observational point prevalence study of Australian and New Zealand ICUs

Author

Anstey, Matthew H., Trent, Louise, Bhonagiri, Deepak, Hammond, Naomi E., Knowles, Serena, McGain, Forbes, Hammond, Naomi, Knowles, Serena, Freeman-Sanderson, Amy, Ganu, Subodh, Howe, Belinda, Litton, Ed, Mackle, Diane, Saxena, Manoj, Seppelt, Ian, Towns, Miriam, Yarad, Elizabeth, Hammond, Knowles, Serena, Gao, Annie, Li, Yang, Myburgh, John, Seppelt, Ian, Nangla, Conrad, Butt, Fatima, Duke, Graeme, Hunter, Stephanie, Evans, Julie, Parker, Dianne, Loughnan, Clare, Thomas, Blessy, Gilder, Eileen, Robertson, Melissa, McMahon, Ellie, Ali, Farisha, Cowdrey, Keri-Anne, McArthur, Colin, Chen, Yan, Simmonds, Catherine, McConnochie, Rachael, O'Connor, Caroline, El-Khawas, Khaled, Hill, Dianne, Cattigan, Claire, Horton, Michelle, Trickey, Jemma, Knott, Cameron, Smith, Julie, Boschert, Catherine, Sara, Treena, Nand, Kiran, Duke, Graeme, Hunter, Stephanie, Evans, Julie, Parker, Dianne, Loughnan, Clare, Thomas, Blessy, Ramanan, Mahesh, Marella, Prashanti, Affleck, Julia, Simpson, Shannon, Ellem, Katrina, McKenna, Toni, Nourse, Mary, Leung, Kristine, Edmunds, Tash, McDonald, Bree, Mehrtens, Jan, Cross, Rosalba, Wong, Helen, Twardowski, Pawel, France, Dawn, Hanlon, Gabrielle, Barrett, Jonathan, Palermo, Annamaria, Pellicano, Susan, Eroglu, Ege, Bihari, Shailesh, Brown, Julia, Grear, Laura, Jin, Xia, French, Craig, Bates, Samantha, Towns, Miriam, Marshall, Fiona, McEldrew, Rebecca, McCullough, James, Tallott, Mandy, Gough, Maimoonbe, Nalos, Marek, Younger, Laura, Krishnamurphy, Ravi, Trent, Louise, How, Janet, Stuart, Anne, Chadwick, Llesley, Bhadange, Neeraj, Tyler, Steven, Sosnowski, Kellie, Morrison, Lynette, Sutton, Joanne, Soar, Natalie, Lee, David, Duke, Graeme, Hunter, Stephanie, Evans, Julie, Parker, Dianne, Loughnan, Clare, Doyle, Marina, Jongebloed, Katherine, Finnis, Mackenzie, Wilson, Jane, Williams, Tony, Song, Rima, Lai, Vivian, Girijadevi, Dinu, Habraken, Hannah, Browne, Alex, Koelle, Jette, McNab, Charlotte, Masters, Kristy, Gresham, Rebecca, Lowrey, Julie, Whitehead, Christina, Liang, Janet, Harward, Meg, Jones, Cassie, Peake, Sandra, Williams, Tricia, Kurenda, Catherine, Tabah, Alexis, Duroux, Maree, Warhurst, Timothy, Ratcliffe, Megan, Pollock, Hamish, Baker, Stuart, Sonawane, Ravikiran, O'Connor, Stephanie, Brown, Nerissa, Glasby, Kathleen, Rivett, Justine, Campbell, Lewis, Tabuzo, Vera, Smyth, Kirsty, Yarad, Elizabeth, Bass, Frances, Hammond, Naomi, O'Connor, Anne, Leonard, Anton, Waterson, Sharon, Coles, Jennifer, Buhr, Heidi, Newman, Duncan, Boorawong, Piyaporn, Bregolin, Vanessa, Yun, Ji-Hyun, Anstey, Matthew, Rock, Lara, Endemann, Anthadene, Lo, Wei, Ferrier, Janet, Palermo, Annamaria, Reynolds, Claire, Santamaria, John, Holmes, Jennifer, Beca, John, Sherring, Claire, Garrett, Peter, Murray, Lauren, Brailsford, Jane, French, Craig, Bates, Samantha, Towns, Miriam, Marshall, Fiona, McEldrew, Rebecca, Browne, Troy, Goodson, Jennifer, Udy, Andrew, Young, Meredith, Board, Jasmin, McCracken, Phoebe, Martin, Emma-Leah, Martynoga, Robert, Butler, Amelia, Trask, Kara, Olatunji, Shaanti, Cruz, Rhoze Sol, Cruz, Raulle Sol, Navarra, Leanlove, Delaney, Kirsha, Lesona, Eden, Young, Chelsea, Spring, Amelia, Aguilar, April, Young, Paul, and Law, Erin

Abstract

During the current COVID pandemic, waste generation has been more evident with increased use of single use masks, gowns and other personal protective equipment. We aimed to understand the scale of waste generation, recycling rates and participation in Australian and New Zealand (ANZ) ICUs.

Published
2023
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20. Volume-outcome relationships for tracheostomies in Australia and New Zealand Intensive Care Units: a registry-based retrospective study.

Author

Marella, Prashanti, Ramanan, Mahesh, Tabah, Alexis, Litton, Ed, Edwards, Felicity, and Laupland, Kevin B.

Abstract

It is unknown whether volume-outcome relationship exists for patients who receive tracheostomy in the Intensive care unit (ICU) as has been observed in other healthcare settings. To determine the average number of tracheostomies performed per Intensivist per ICU in Australia and New Zealand (ANZ), and associations with case-fatality.

Published
2025
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22. Use of Adaptive Support Ventilation (ASV) in Ventilator Associated Pneumonia (VAP) - A Case Report

Author

Kath, Bipphy, Hemanth, N., Marella, Prashanti, and Rao, M.

Subjects
Bacterial pneumonia -- Care and treatment, Bacterial pneumonia -- Patient outcomes, Bacterial pneumonia -- Case studies, Pneumonia -- Care and treatment, Pneumonia -- Patient outcomes, Pneumonia -- Case studies, Artificial respiration -- Health aspects, Artificial respiration -- Patient outcomes, Subdural hematoma -- Diagnosis, Subdural hematoma -- Care and treatment, Subdural hematoma -- Patient outcomes, Subdural hematoma -- Case studies
Abstract

Byline: Bipphy. Kath, N. Hemanth, Prashanti. Marella, M. Rao Prolonged ventilation leads to a higher incidence of ventilator associated pneumonia(VAP) resulting in ventilator dependency, increased costs and subsequent weaning failures. [...]

Published
2009

23. How often are infusion sets for central venous catheters changed in Australian and New Zealand Intensive Care Units? A point prevalence survey

Author

Anstey, Matthew H., Maxwell, Nicky, Rickard, Claire M., Hammond, Naomi E., Knowles, Serena, McGain, Forbes, Hammond, Naomi, Knowles, Serena, Freeman-Sanderson, Amy, Ganu, Subodh, Howe, Belinda, Litton, Ed, Mackle, Diane, Saxena, Manoj, Seppelt, Ian, Towns, Miriam, Yarad, Elizabeth, Hammond, Naomi, Knowles, Serena, Gao, Annie, Li, Yang, Myburgh, John, Seppelt, Ian, Nangla, Conrad, Butt, Fatima, Duke, Graeme, Hunter, Stephanie, Evans, Julie, Parker, Dianne, Loughnan, Clare, Thomas, Blessy, Gilder, Eileen, Robertson, Melissa, McMahon, Ellie, Ali, Farisha, Cowdrey, Keri-Anne, McArthur, Colin, Chen, Yan, Simmonds, Catherine, McConnochie, Rachael, O’Connor, Caroline, El-Khawas, Khaled, Hill, Dianne, Cattigan, Claire, Horton, Michelle, Trickey, Jemma, Knott, Cameron, Smith, Julie, Boschert, Catherine, Sara, Treena, Nand, Kiran, Duke, Graeme, Hunter, Stephanie, Evans, Julie, Parker, Dianne, Loughnan, Clare, Thomas, Blessy, Ramanan, Mahesh, Marella, Prashanti, Affleck, Julia, Simpson, Shannon, Ellem, Katrina, McKenna, Toni, Nourse, Mary, Leung, Kristine, Edmunds, Tash, McDonald, Bree, Mehrtens, Jan, Cross, Rosalba, Wong, Helen, Twardowski, Pawel, France, Dawn, Hanlon, Gabrielle, Barrett, Jonathan, Palermo, Annamaria, Pellicano, Susan, Eroglu, Ege, Bihari, Shailesh, Brown, Julia, Grear, Laura, Jin, Xia, French, Craig, Bates, Samantha, Towns, Miriam, Marshall, Fiona, McEldrew, Rebecca, McCullough, James, Tallott, Mandy, Gough, Maimoonbe, Nalos, Marek, Younger, Laura, Krishnamurphy, Ravi, Trent, Louise, How, Janet, Stuart, Anne, Chadwick, Llesley, Bhadange, Neeraj, Tyler, Steven, Sosnowski, Kellie, Morrison, Lynette, Sutton, Joanne, Soar, Natalie, Lee, David, Duke, Graeme, Hunter, Stephanie, Evans, Julie, Parker, Dianne, Loughnan, Clare, Doyle, Marina, Jongebloed, Katherine, Finnis, Mackenzie, Wilson, Jane, Williams, Tony, Song, Rima, Lai, Vivian, Girijadevi, Dinu, Habraken, Hannah, Browne, Alex, Koelle, Jette, McNab, Charlotte, Masters, Kristy, Gresham, Rebecca, Lowrey, Julie, Whitehead, Christina, Liang, Janet, Harward, Meg, Jones, Cassie, Peake, Sandra, Williams, Tricia, Kurenda, Catherine, Tabah, Alexis, Duroux, Maree, Warhurst, Timothy, Ratcliffe, Megan, Pollock, Hamish, Baker, Stuart, Sonawane, Ravikiran, O'Connor, Stephanie, Brown, Nerissa, Glasby, Kathleen, Rivett, Justine, Campbell, Lewis, Tabuzo, Vera, Smyth, Kirsty, Yarad, Elizabeth, Bass, Frances, Hammond, Naomi, O'Connor, Anne, Leonard, Anton, Waterson, Sharon, Coles, Jennifer, Buhr, Heidi, Newman, Duncan, Boorawong, Piyaporn, Bregolin, Vanessa, Yun, Ji-Hyun, Anstey, Matthew, Rock, Lara, Endemann, Anthadene, Lo, Wei, Ferrier, Janet, Palermo, Annamaria, Reynolds, Claire, Santamaria, John, Holmes, Jennifer, Beca, John, Sherring, Claire, Garrett, Peter, Murray, Lauren, Brailsford, Jane, French, Craig, Bates, Samantha, Towns, Miriam, Marshall, Fiona, McEldrew, Rebecca, Browne, Troy, Goodson, Jennifer, Udy, Andrew, Young, Meredith, Board, Jasmin, McCracken, Phoebe, Martin, Emma-Leah, Martynoga, Robert, Butler, Amelia, Trask, Kara, Olatunji, Shaanti, Cruz, Rhoze Sol, Cruz, Raulle Sol, Navarra, Leanlove, Delaney, Kirsha, Lesona, Eden, Young, Chelsea, Spring, Amelia, Aguilar, April, Young, Paul, and Law, Erin

Abstract

Infusion sets (comprising the tubing, measuring burettes, fluid containers, transducers) that are connected to invasive vascular devices are changed on a regular basis in an effort to reduce bacterial colonisation and bloodstream infection. There is a balance between reducing infection and creating unnecessary waste. Current evidence suggests that for central venous catheters, changing infusion sets at 7 days does not increase infection risks.

Published
2023
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24. Composite Primary Outcomes Reported in Studies of Critical Care: A Scoping Review.

Author

Marella P, De Silva S, Attokaran AG, Laupland KB, Eriksson L, and Ramanan M

Subjects
Humans, Outcome Assessment, Health Care, Intensive Care Units, Critical Care methods
Abstract

Objective: Composite primary outcomes (CPO) (incorporating both mortality and non-mortality outcomes) offer several advantages over mortality as an outcome for critical care research. Our objective was to explore and map the literature to report on CPO evaluated in critical care research., Data Sources: PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, Scopus, and Cochrane Library from January 2000 to January 2024., Study Selection: All studies (both non-randomized controlled trial [RCT] and RCT) conducted in ICUs treating adult patients (18 yr old or older) that described CPOs and their definitions, were included for mapping, reporting, and analyzing CPOs without any restrictions., Data Extraction: Independent double-screening of abstracts/full texts and data extraction was performed using a pilot-tested extraction template. The data collected included characteristics of CPO, definitions, trends, and death handling techniques used while reporting the CPO., Data Synthesis: Seventeen CPOs were extracted from 71 studies, predominantly reported in the setting of pharmaceutical studies (48/71, 67.6%), used RCT methodology (60/71, 84.5%), and were mostly single-center studies (55/71, 77.5%). Ventilator-free days were the most commonly reported CPO (29/71, 40.8%) with marked variability in the definition used and death handling (0 d in 33 studies and -1 d in 7 studies). The most common statistical paradigm used was frequentist (63/71, 88.7%) and the study follow-up time was 90 days with 28 studies using this timeline (28/71, 39.4%). Narrative synthesis highlighted the variability in defining CPO., Conclusions: CPOs are an emerging set of outcomes increasingly reported in critical care research. There was significant heterogeneity in definitions used, follow-up times, and reporting trends., Competing Interests: The authors have disclosed that they do not have any potential conflicts of interest., (Copyright © 2025 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.)

Published
2025
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