867 results on '"Mardinoglu, Adil"'
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2. Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability
3. Drug repositioning for immunotherapy in breast cancer using single-cell analysis
4. Boric Acid and Borax Protect Human Lymphocytes from Oxidative Stress and Genotoxicity Induced by 3-Monochloropropane-1,2-diol
5. Synthesis, spectroscopic characterization, DFT and molecular docking of N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl) naphthalene-1-sulfonamide derivatives
6. Unveiling structural features, chemical reactivity, and bioactivity of a newly synthesized purine derivative through crystallography and computational approaches
7. Genome-wide expression analysis in a Fabry disease human podocyte cell line
8. Novel drug targets and molecular mechanisms for sarcopenia based on systems biology
9. A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in ovariectomized rats
10. Design and evaluation of novel inhibitors for the treatment of clear cell renal cell carcinoma
11. Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma
12. Sulfone-based human liver pyruvate kinase inhibitors – Design, synthesis and in vitro bioactivity
13. A comparison between different human hepatocyte models reveals profound differences in net glucose production, lipid composition and metabolism in vitro
14. Systematic transcriptional analysis of human cell lines for gene expression landscape and tumor representation
15. Next generation pan-cancer blood proteome profiling using proximity extension assay
16. Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients
17. Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia
18. Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial
19. Remodeling of the human skeletal muscle proteome found after long-term endurance training but not after strength training
20. The multifaceted role of post-translational modifications of LSD1 in cellular processes and disease pathogenesis
21. Molecular profiling of high-level athlete skeletal muscle after acute endurance or resistance exercise – A systems biology approach
22. Tuning of CHO secretional machinery improve activity of secreted therapeutic sulfatase 150-fold
23. Multi-omics network analysis on samples from sequential biopsies reveals vital role of proliferation arrest for Macrosteatosis related graft failure in rats after liver transplantation
24. Characterization of an in vitro steatosis model simulating activated de novo lipogenesis in MAFLD patients
25. The acute effect of different NAD+ precursors included in the combined metabolic activators
26. Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators
27. Discovery of drug targets and therapeutic agents based on drug repositioning to treat lung adenocarcinoma
28. Publisher Correction: MEMOTE for standardized genome-scale metabolic model testing
29. An atlas of human metabolism
30. BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH
31. Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats
32. Development of l-Dopa-containing diketopiperazines as blood-brain barrier shuttle
33. Revisiting the role of serine metabolism in hepatic lipogenesis
34. Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning
35. Genome-scale metabolic modelling of the human gut microbiome reveals changes in the glyoxylate and dicarboxylate metabolism in metabolic disorders
36. Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase
37. Genome-wide annotation of protein-coding genes in pig
38. Transient colonizing microbes promote gut dysbiosis and functional impairment.
39. Discovery of Cell-Permeable Allosteric Inhibitors of Liver Pyruvate Kinase: Design and Synthesis of Sulfone-Based Urolithins.
40. Discovery of a Therapeutic Agent for Glioblastoma Using a Systems Biology-Based Drug Repositioning Approach.
41. A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease
42. Altered Hippocampal Connectivity is Associated With Cognitive Impairment in Migraine Patients
43. Integrative Proteo-Transcriptomic Characterization of Advanced Fibrosis in Chronic Liver Disease Across Etiologies
44. Multi-Tissue Network Analysis Reveals the Effect of JNK Inhibition on Dietary Sucrose-Induced Metabolic Dysfunction in Rats
45. Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning
46. Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI
47. Acute kidney injury leading to CKD is associated with a persistence of metabolic dysfunction and hypertriglyceridemia
48. Spatiotemporal dissection of the cell cycle with single-cell proteogenomics
49. Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells
50. Synthesis and Biological Evaluation of Novel Benzylidene Thiazolo Pyrimidin-3(5H)-One Derivatives.
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