Search

Your search keyword '"Marcus, Roy P."' showing total 121 results
Start Over Author "Marcus, Roy P."
121 results on '"Marcus, Roy P."'

4. Computed tomography angiography versus Agatston score for diagnosis of coronary artery disease in patients with stable chest pain: individual patient data meta-analysis of the international COME-CCT Consortium

Author

Wieske, Viktoria, Walther, Mario, Dubourg, Benjamin, Alkadhi, Hatem, Nørgaard, Bjarne L, Meijs, Matthijs FL, Diederichsen, Axel CP, Wan, Yung-Liang, Mickley, Hans, Nikolaou, Konstantin, Shabestari, Abbas A, Halvorsen, Bjørn A, Martuscelli, Eugenio, Sun, Kai, Herzog, Bernhard A, Marcus, Roy P, Leschka, Sebastian, Garcia, Mario J, Ovrehus, Kristian A, Knuuti, Juhani, Mendoza-Rodriguez, Vladymir, Bettencourt, Nuno, Muraglia, Simone, Buechel, Ronny R, Kaufmann, Philipp A, Zimmermann, Elke, Tardif, Jean-Claude, Budoff, Matthew J, Schlattmann, Peter, and Dewey, Marc

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Heart Disease - Coronary Heart Disease, Atherosclerosis, Cardiovascular, Heart Disease, Biomedical Imaging, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Calcium, Chest Pain, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Coronary Stenosis, Humans, Predictive Value of Tests, Tomography, X-Ray Computed, Computed tomography angiography, Coronary angiography, Coronary artery disease, COME-CCT Consortium, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

ObjectivesThere is conflicting evidence about the comparative diagnostic accuracy of the Agatston score versus computed tomography angiography (CTA) in patients with suspected obstructive coronary artery disease (CAD).PurposeTo determine whether CTA is superior to the Agatston score in the diagnosis of CAD.MethodsIn total 2452 patients with stable chest pain and a clinical indication for invasive coronary angiography (ICA) for suspected CAD were included by the Collaborative Meta-analysis of Cardiac CT (COME-CCT) Consortium. An Agatston score of > 400 was considered positive, and obstructive CAD defined as at least 50% coronary diameter stenosis on ICA was used as the reference standard.ResultsObstructive CAD was diagnosed in 44.9% of patients (1100/2452). The median Agatston score was 74. Diagnostic accuracy of CTA for the detection of obstructive CAD (81.1%, 95% confidence interval [CI]: 77.5 to 84.1%) was significantly higher than that of the Agatston score (68.8%, 95% CI: 64.2 to 73.1%, p < 0.001). Among patients with an Agatston score of zero, 17% (101/600) had obstructive CAD. Diagnostic accuracy of CTA was not significantly different in patients with low to intermediate (1 to < 100, 100-400) versus moderate to high Agatston scores (401-1000, > 1000).ConclusionsResults in our international cohort show CTA to have significantly higher diagnostic accuracy than the Agatston score in patients with stable chest pain, suspected CAD, and a clinical indication for ICA. Diagnostic performance of CTA is not affected by a higher Agatston score while an Agatston score of zero does not reliably exclude obstructive CAD.Key points• CTA showed significantly higher diagnostic accuracy (81.1%, 95% confidence interval [CI]: 77.5 to 84.1%) for diagnosis of coronary artery disease when compared to the Agatston score (68.8%, 95% CI: 64.2 to 73.1%, p < 0.001). • Diagnostic performance of CTA was not affected by increased amount of calcium and was not significantly different in patients with low to intermediate (1 to 1000). • Seventeen percent of patients with an Agatston score of zero showed obstructive coronary artery disease by invasive angiography showing absence of coronary artery calcium cannot reliably exclude coronary artery disease.

Published
2022

7. Correction to: Computed tomography angiography versus Agatston score for diagnosis of coronary artery disease in patients with stable chest pain: individual patient data meta-analysis of the international COME-CCT Consortium

Author

Wieske, Viktoria, Walther, Mario, Dubourg, Benjamin, Alkadhi, Hatem, Nørgaard, Bjarne L., Meijs, Matthijs F. L., Diederichsen, Axel C. P., Wan, Yung-Liang, Mickley, Hans, Nikolaou, Konstantin, Shabestari, Abbas A., Halvorsen, Bjørn A., Martuscelli, Eugenio, Sun, Kai, Herzog, Bernhard A., Marcus, Roy P., Leschka, Sebastian, Garcia, Mario J., Ovrehus, Kristian A., Knuuti, Juhani, Mendoza-Rodriguez, Vladymir, Bettencourt, Nuno, Muraglia, Simone, Buechel, Ronny R., Kaufmann, Philipp A., Zimmermann, Elke, Tardif, Jean-Claude, Budoff, Matthew J., Schlattmann, Peter, and Dewey, Marc

Published
2022
Full Text
View/download PDF

10. Fat Fractions of the Rotator Cuff Muscles Acquired With 2-Point Dixon MRI: Predicting Outcome After Arthroscopic Rotator Cuff Repair

Author

Feuerriegel, Georg C, Marcus, Roy P, Sommer, Stefan; https://orcid.org/0000-0002-4092-7068, Wieser, Karl; https://orcid.org/0000-0001-8495-6189, Bouaicha, Samy; https://orcid.org/0000-0002-1111-9213, Sutter, Reto; https://orcid.org/0000-0001-6355-9838, Feuerriegel, Georg C, Marcus, Roy P, Sommer, Stefan; https://orcid.org/0000-0002-4092-7068, Wieser, Karl; https://orcid.org/0000-0001-8495-6189, Bouaicha, Samy; https://orcid.org/0000-0002-1111-9213, and Sutter, Reto; https://orcid.org/0000-0001-6355-9838

Abstract

OBJECTIVES The aim of this study was to quantify and compare fat fraction (FF) and muscle volume between patients with failed and intact rotator cuff (RC) repair as well as a control group with nonsurgical conservative treatment to define FF cutoff values for predicting the outcome of RC repair. MATERIALS AND METHODS Patients with full-thickness RC tears who received magnetic resonance imaging (MRI) before and after RC repair including a 2-point Dixon sequence were retrospectively screened. Patients with retear of 1 or more tendons diagnosed on MRI (Sugaya IV-V) were enrolled and matched to patients with intact RC repair (Sugaya I-II) and to a third group with conservatively treated RC tears. Two radiologists evaluated morphological features (Cofield, Patte, and Goutallier), as well as the integrity of the RC after repair (Sugaya). Fat fractions were calculated from the 2-point Dixon sequence, and the RC muscles were segmented semiautomatically to calculate FFs and volume for each muscle. Receiver operator characteristics curves were used to determine FF cutoff values that best predict RC retears. RESULTS In total, 136 patients were enrolled, consisting of 3 groups: 41 patients had a failed RC repair (58 ± 7 years, 16 women), 50 patients matched into the intact RC repair group, and 45 patients were matched into the conservative treatment group. Receiver operator characteristics curves showed reliable preoperative FF cutoff values for predicting retears at 6.0% for the supraspinatus muscle (0.83 area under the curve [AUC]), 7.4% for the infraspinatus muscle (AUC 0.82), and 8.3% for the subscapularis muscle (0.94 AUC). CONCLUSIONS Preoperative quantitative FF calculated from 2-point Dixon MRI can be used to predict the risk of retear after arthroscopic RC repair with cutoff values between 6% and 8.3%.

Published
2024

13. Individual patient data meta-analysis for the clinical assessment of coronary computed tomography angiography: protocol of the Collaborative Meta-Analysis of Cardiac CT (CoMe-CCT)

Author

Schuetz, Georg M, Schlattmann, Peter, Achenbach, Stephan, Budoff, Matthew, Garcia, Mario J, Roehle, Robert, Pontone, Gianluca, Meijboom, Willem Bob, Andreini, Daniele, Alkadhi, Hatem, Honoris, Lily, Bettencourt, Nuno, Hausleiter, Jörg, Leschka, Sebastian, Gerber, Bernhard L, Meijs, Matthijs FL, Shabestari, Abbas Arjmand, Sato, Akira, Zimmermann, Elke, Schoepf, Uwe J, Diederichsen, Axel, Halon, David A, Mendoza-Rodriguez, Vladimir, Hamdan, Ashraf, Nørgaard, Bjarne L, Brodoefel, Harald, Øvrehus, Kristian A, Jenkins, Shona MM, Halvorsen, Bjørn A, Rixe, Johannes, Sheikh, Mehraj, Langer, Christoph, Martuscelli, Eugenio, Romagnoli, Andrea, Scholte, Arthur JHA, Marcus, Roy P, Ulimoen, Geir R, Nieman, Koen, Mickley, Hans, Nikolaou, Konstantin, Tardif, Jean-Claude, Johnson, Thorsten RC, Muraglia, Simone, Chow, Benjamin JW, Maintz, David, Laule, Michael, and Dewey, Marc

Abstract

Abstract Background Coronary computed tomography angiography has become the foremost noninvasive imaging modality of the coronary arteries and is used as an alternative to the reference standard, conventional coronary angiography, for direct visualization and detection of coronary artery stenoses in patients with suspected coronary artery disease. Nevertheless, there is considerable debate regarding the optimal target population to maximize clinical performance and patient benefit. The most obvious indication for noninvasive coronary computed tomography angiography in patients with suspected coronary artery disease would be to reliably exclude significant stenosis and, thus, avoid unnecessary invasive conventional coronary angiography. To do this, a test should have, at clinically appropriate pretest likelihoods, minimal false-negative outcomes resulting in a high negative predictive value. However, little is known about the influence of patient characteristics on the clinical predictive values of coronary computed tomography angiography. Previous regular systematic reviews and meta-analyses had to rely on limited summary patient cohort data offered by primary studies. Performing an individual patient data meta-analysis will enable a much more detailed and powerful analysis and thus increase representativeness and generalizability of the results. The individual patient data meta-analysis is registered with the PROSPERO database (CoMe-CCT, CRD42012002780). Methods/Design The analysis will include individual patient data from published and unpublished prospective diagnostic accuracy studies comparing coronary computed tomography angiography with conventional coronary angiography. These studies will be identified performing a systematic search in several electronic databases. Corresponding authors will be contacted and asked to provide obligatory and additional data. Risk factors, previous test results and symptoms of individual patients will be used to estimate the pretest likelihood of coronary artery disease. A bivariate random-effects model will be used to calculate pooled mean negative and positive predictive values as well as sensitivity and specificity. The primary outcome of interest will be positive and negative predictive values of coronary computed tomography angiography for the presence of coronary artery disease as a function of pretest likelihood of coronary artery disease, analyzed by meta-regression. As a secondary endpoint, factors that may influence the diagnostic performance and clinical value of computed tomography, such as heart rate and body mass index of patients, number of detector rows, and administration of beta blockade and nitroglycerin, will be investigated by integrating them as further covariates into the bivariate random-effects model. Discussion This collaborative individual patient data meta-analysis should provide answers to the pivotal question of which patients benefit most from noninvasive coronary computed tomography angiography and thus help to adequately select the right patients for this test.

Published
2013

19. Applicability and accuracy of pretest probability calculations implemented in the NICE clinical guideline for decision making about imaging in patients with chest pain of recent onset

Author

Roehle, Robert, Wieske, Viktoria, Schuetz, Georg M., Gueret, Pascal, Andreini, Daniele, Meijboom, Willem Bob, Pontone, Gianluca, Garcia, Mario, Alkadhi, Hatem, Honoris, Lily, Hausleiter, Jörg, Bettencourt, Nuno, Zimmermann, Elke, Leschka, Sebastian, Gerber, Bernhard, Rochitte, Carlos, Schoepf, U. Joseph, Shabestari, Abbas Arjmand, Nørgaard, Bjarne, Sato, Akira, Knuuti, Juhani, Meijs, Matthijs F. L., Brodoefel, Harald, Jenkins, Shona M. M., Øvrehus, Kristian Altern, Diederichsen, Axel Cosmus Pyndt, Hamdan, Ashraf, Halvorsen, Bjørn Arild, Mendoza Rodriguez, Vladimir, Wan, Yung Liang, Rixe, Johannes, Sheikh, Mehraj, Langer, Christoph, Ghostine, Said, Martuscelli, Eugenio, Niinuma, Hiroyuki, Scholte, Arthur, Nikolaou, Konstantin, Ulimoen, Geir, Zhang, Zhaoqi, Mickley, Hans, Nieman, Koen, Kaufmann, Philipp A., Buechel, Ronny Ralf, Herzog, Bernhard A., Clouse, Melvin, Halon, David A., Leipsic, Jonathan, Bush, David, Jakamy, Reda, Sun, Kai, Yang, Lin, Johnson, Thorsten, Laissy, Jean-Pierre, Marcus, Roy, Muraglia, Simone, Tardif, Jean-Claude, Chow, Benjamin, Paul, Narinder, Maintz, David, Hoe, John, de Roos, Albert, Haase, Robert, Laule, Michael, Schlattmann, Peter, and Dewey, Marc

Published
2018
Full Text
View/download PDF

20. Correction to: Applicability and accuracy of pretest probability calculations implemented in the NICE clinical guideline for decision making about imaging in patients with chest pain of recent onset

Author

Roehle, Robert, Wieske, Viktoria, Schuetz, Georg M., Gueret, Pascal, Andreini, Daniele, Meijboom, Willem Bob, Pontone, Gianluca, Garcia, Mario, Alkadhi, Hatem, Honoris, Lily, Hausleiter, Jörg, Bettencourt, Nuno, Zimmermann, Elke, Leschka, Sebastian, Gerber, Bernhard, Rochitte, Carlos, Schoepf, U. Joseph, Shabestari, Abbas Arjmand, Nørgaard, Bjarne, Sato, Akira, Knuuti, Juhani, Meijs, Matthijs F. L., Brodoefel, Harald, Jenkins, Shona M. M., Øvrehus, Kristian Altern, Diederichsen, Axel Cosmus Pyndt, Hamdan, Ashraf, Halvorsen, Bjørn Arild, Rodriguez, Vladimir Mendoza, Wan, Yung Liang, Rixe, Johannes, Sheikh, Mehraj, Langer, Christoph, Ghostine, Said, Martuscelli, Eugenio, Niinuma, Hiroyuki, Scholte, Arthur, Nikolaou, Konstantin, Ulimoen, Geir, Zhang, Zhaoqi, Mickley, Hans, Nieman, Koen, Kaufmann, Philipp A., Buechel, Ronny Ralf, Herzog, Bernhard A., Clouse, Melvin, Halon, David A., Leipsic, Jonathan, Bush, David, Jakamy, Reda, Sun, Kai, Yang, Lin, Johnson, Thorsten, Laissy, Jean-Pierre, Marcus, Roy, Muraglia, Simone, Tardif, Jean-Claude, Chow, Benjamin, Paul, Narinder, Maintz, David, Hoe, John, de Roos, Albert, Haase, Robert, Laule, Michael, Schlattmann, Peter, and Dewey, Marc

Published
2018
Full Text
View/download PDF

22. Correction to:Computed tomography angiography versus Agatston score for diagnosis of coronary artery disease in patients with stable chest pain: individual patient data meta-analysis of the international COME-CCT Consortium (European Radiology, (2022), 32, 8, (5233-5245), 10.1007/s00330-022-08619-4)

Author

Wieske, Viktoria, Walther, Mario, Dubourg, Benjamin, Alkadhi, Hatem, Nørgaard, Bjarne L, Meijs, Matthijs F L, Diederichsen, Axel C P, Wan, Yung-Liang, Mickley, Hans, Nikolaou, Konstantin, Shabestari, Abbas A, Halvorsen, Bjørn A, Martuscelli, Eugenio, Sun, Kai, Herzog, Bernhard A, Marcus, Roy P, Leschka, Sebastian, Garcia, Mario J, Ovrehus, Kristian A, Knuuti, Juhani, Mendoza-Rodriguez, Vladymir, Bettencourt, Nuno, Muraglia, Simone, Buechel, Ronny R, Kaufmann, Philipp A, Zimmermann, Elke, Tardif, Jean-Claude, Budoff, Matthew J, Schlattmann, Peter, and Dewey, Marc

Abstract

The original version of this article, published on 10 March 2022, unfortunately contained a mistake. The author name Bjarne L. Nørgaard was incorrectly given as Bjarne L. Nørgard. The original article has been corrected.

Published
2022
Full Text
View/download PDF

24. Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: a randomised, controlled, phase 2 trial

Author

Tuttle, Katherine R, Hauske, Sibylle J, Canziani, Maria Eugenia, Caramori, Maria Luiza, Cherney, David, Cronin, Lisa, Heerspink, Hiddo J L, Hugo, Christian, Nangaku, Masaomi, Rotter, Ricardo Correa, Silva, Arnold, Shah, Shimoli V, Sun, Zhichao, Urbach, Dorothea, de Zeeuw, Dick, Rossing, Peter, Tuttle, Katherine R, Hauske, Sibylle J, Canziani, Maria Eugenia, Caramori, Maria Luiza, Cherney, David, Cronin, Lisa, Heerspink, Hiddo J L, Hugo, Christian, Nangaku, Masaomi, Rotter, Ricardo Correa, Silva, Arnold, Shah, Shimoli V, Sun, Zhichao, Urbach, Dorothea, de Zeeuw, Dick, Rossing, Peter, SZETO, Cheuk Chun, Echeverri, Diego, Martin, Edouard, Yee, Ming Li, Wah, William, Wang, Ray, Chacko, Bobby, Swaminathan, Shriram, MacIsaac, Richard, Hashimura, Hikaru, Ward, Glenn, De Vusser, Katrien, Claes, Kathleen, Kuypers, Dirk, Meijers, Björn, Van Craenenbroeck, Amaryllis, Hilbrands, Robert, Debroye, Corinne, Wissing, Karl Martin, Jadoul, Michel, Demoulin, Nathalie, Treille De Grandsaigne, Serge, Beklevic, Ishak, Marcoux, Diane, Liénart, Fabienne, Daper, Claude, De Brouckere, Véronique, Heureux, Mercédès, Felicio, Joao, Felicio, Karem Mileo, Leite, Daniella, Melo, Franciane, Queiroz, Natercia, Souza, Ana Carolina, Vieira, Jocyelle, Franco, Roberto, Mendes, Adriana, Picolli, Giovana, Canani, Luis Henrique, Sartori, Carla, Valenti, Adriana, Eliaschewitz, Freddy, Bona, Renata, Franco, Denise, Ludovico Costa de Castro, Denise, Magalhaes, Vanessa, Oliveira, Marcelo, Sampaio, Célia Regina, Visconti, Guilherme, Halpern, Bruno, Nihei, Camila, Pessoa, Bruna, Seraphim, Carlos, Santos, Daniel, Brito, Claudia, Douverny, Joao, Colella, Marina, Gazeta, Cristina, Vercia, Monique, Watanabe, Renato, Temelkova, Theodora, Kjurkchiev, Dimo, Statkova, Silviya, Popov, Iliya, Radeva, Radosveta, Arabadzhiev, Lachezar, Binova, Mariya, Bosilkov, Aleksandar, Koleva-Stoicheva, Neli, Ivanov, Ivaylo, Ivanova, Zornitsa, Kotseva, Viktoria, Spasov, Petar, Tsvetkov, Ivaylo, Jolly, Shivinder, Bailey, Gordon, Ye, Zhiming, Niu, Jianying, Li, Hongmei, Wu, Qing, Liao, Bing, Hao, Chuanming, Lai, Lingyun, Xu, Yunyu, Zhang, Min, Li, Yiwen, Liu, Bo, Shao, Lina, Chen, Wei, Wu, Haishan, Pirchala, Marian, Skarpova, Iva, Hraskova, Marketa, Soukupova, Simoneta, Veberova, Lucie, Drasnar, Tomas, Falc, Matej, Racz, Blazej, Votocek, Stepan, Weissova, Danica, Syc-Krivanova, Lenka, Slezak, Dagmar, Kantola, Ilkka, Nieminen, Sakari, Anttonen, Milla, Taurio, Jyrki, Lahtela, Jorma, Tsimihodimos, Vasileios, Balafa, Olga, Dounousi, Evangelia, Sakkou, Sissy, Tentolouris, Nikolaos, Siafarikas, Christos, Siami, Evangelia, Doupis, Ioannis, Angelopoulos, Theodoros, Georgoulias, Christodoulos, Pall, Denes, Esze, Regina, Kobling, Tamas, Varadi, Zita, Zsiros, Noemi, Vass, Viktor, Balo, Timea, Csanyi, Erika, Ory, Ivan, Pall, Istvan, Patai, Valentina, Zeak, Zsuzsanna, Takacs, Istvan, Petho, Akos, Szili, Balazs, Koranyi, Laszlo, Bezzegh, Katalin, Pauer, Jozsef, Peterfai, Eva, Konyves, Laszlo, Szoke, Brigitta, Hajdu, Csaba, Kalman, Krisztina, Yadav, Raj, Saxena, Navneet, Bhattacharya, Meenakshi, Sharma, Bal, Thomas, Nihal, K, Felix Jebasingh, Kapoor, Nitin, Kurian, Mathews E., Paul, Jinson, Ramesh, Priyadharshini, Varghese, Sheeba, Shibusawa, Nobuyuki, Nishi, Hiroshi, Noritake, Nobuyasu, Oda, Takashi, Okamoto, Hideki, Kasuga, Hirotake, Hori, Hiroshi, Ito, Yukiko, Mizukoshi, Toshihiro, Ishii, Hideto, Han, Seung Hyeok, Kim, Hyung Woo, Oh, Kook-Hwan, Han, Seung Seok, Han, Sang Youb, Cha, Dae Ryong, Cha, Jin Joo, Kwon, Soon-Kil, Cho, Hyunjeong, Kim, Hye-Young, Kim, Sun Moon, Lee, Jung Pyo, Lee, Jeonghwan, Lee, Li Yuan, Chang, Meng Lee, Laang, Shian Tuck, Tan, Zhao Zhi, Ahmad Rosdi, Hajar, Mohammad Ismail, Siti Hafizah, Simatherai, Devamalar, Tay, Ju Fan, Eddie, Wong, Fook Sem, Yakob, Suryati, Abdul Sukur, Noorhafini, Anuar, Amalina, Md. Rasid, Syaliza, Mushaddik, Irma Liyana, Mustafar, Ruslinda, Abu Shamsi, Muhammad Yusuf, Fong, Voon Ken, Kamaruzaman, Lydia, Mohd, Rozita, Wan Daud, Wan Rohaslizan, Wan Hassan, Wan Hasnul Halimi, Ab Hamid, Suhaidarwani, Abdullah, Muhammad Nabil, Yusoff, Mohd Yusran, Ramanathan, G R Letchuman, Lee, Kim Yen, Wan Ismail, Wan Fadhilah, Morales Villegas, Enrique, Ramirez Baez, Rubria, Vital Lopez, Jorge, Arias Delgadillo, Cristhian, Herrera Marmolejo, Marisol, Parra Perez, Rosa, Alpizar Salazar, Melchor, Flores Montealegre, Ana, Galvan Magaña, Jose, Gutierrez Tlapale, Minerva, Reyes Munguia, Daniela, Witczak, Bartlomiej, Gøransson, Lasse, Strand Thorsen, Inga, Caringal, Clodoaido, Villardo, Mario, Toledo, Ronaldo, Dijamco, Emerlinda Fausto, De Asis, Norman Cornelio, Kuizon, Angelica, Catindig, Elizabeth Ann, Perez, Ronald, Aquitania, Grace, Pableo, Jimrie David, Sanchez, Jay Karlou, Czernecka, Ewa, Cegiel, Aleksandra, Knychas, Dorota, Ochnio, Malgorzata, Kuligowska-Jakubowska, Monika, Cesarz, Marek, Kowalewska-Celejewska, Milena, Masajtis-Zagajewska, Anna, Jankowski, Lukasz, Ojrzanowski, Marcin, Olszewska-Jander, Magdalena, Skokowska, Ewa, Giermakowska-Samek, Malgorzata, Luchowska, Elzbieta, Patkowska, Renata, Sekulska, Marzenna, Marczuk-Krynicka, Dorota, Marciniak, Andrzej, Barwijuk, Michal, Myslicki, Marcin, Siek, Michal, Wronska, Danuta, Tomsia-Goncerz, Jadwiga, Wronski, Krzysztof, Junik, Roman, Dzialak, Szymon, Kurlapska, Ewelina, Malecha, Wieslaw, Suwala, Szymon, Branco, Patrícia, Birne, Rita, Raposo, João, Ferreira, Marta, Alexandrino, Henrique, Alves, Helena, Correia, Sara, Oliveira, Maria João, Ramalho, Diogo, Tavares, Patricia, Coetzee, Kathleen, Blignaut, Sue, Viljoen, Winifred, Potgieter, Elsje, Malherbe, Elmien, Ortiz Arduán, Alberto, Goma Garcés, Elena, Pérez, María, Santamaría, Rafael, López López, Isabel, Pendón de Mier, Victoria, Rodelo Haad, Cristian, Marques, María, Domènech, Esther, Portoles, Josep Maria, Soler, María José, Agraz, Irene, Azancot, María Antonieta, Bermejo, Sheila, Bolufer, Mónica, López, Marina, Ramos, Natalia, Toapanta, Néstor, Cigarrán Guldris, Secundino, Primo, Juan Carlos, Pérez, Luis Enrique, Rebollido Fernández, María, Holmer, Helene, Bruchfeld, Annette, Rofors, Justus, Tengmark, Bengt-Olov, Wuerzner, Gregoire, Leanizbarrutia, Garazi, Ozturk, Savas, Guler, Nurana, Safak, Seda, Lee, Keung, Campbell, Stephen, Siddiqui, Imran, Abbasi, Nadia, Tahir, Faiza, Azizad, Masoud, Jackson, Timothy, Everhart, Brian, Oliver, Michael, Rust, William, Sniezek, Matthew, Arif, Ahmed, Syed, Mohammed, Bhasin, Nitin, Bien, Michael, Gallego, Claudio, Jamal, Aamir, Moghadam, Mojtaba, Rizvi, Abid, Rizvi, Amna, Rizvi, Syed, Wong, Christopher, Lucas, Kathryn, Buery, Andrea, Chang, Ku-Lang, Presswood, Claire, Smith, Justin, Doshi, Ankur, Parikh, Manish, Wallace, Jeannine, Krishna, Arvind, Daugherty, Heidi, Fearday, Aaron, Keller, Christopher, Meng, Jerry, Nielsen, Alexandra, Rovner, Sergio, Almeida, Javier, Marranzini, Benito, Selby, Lisa, Yablon, Zachary, Jean-Louis, Daphne, Kotzker, Wayne, Perez, Chabely, Richards, Marc, Rosario, Reinaldo, Marcus, Roy, Okechukwu, Chike, Ross, Dennis, Gromala, Rachel, Reed, Matthew, Weber, Lisa, Nazeer, Imran, Kumar, Prashant, Mir, Muhammad, Shea, Heidi, Hart, Amanda, Wiebel, Jaime, Kooienga, Laura, Newsome, Britt, Suyumova, Irina, Alvarez, German, Bireddy, Venkata, Lansang, Maria, Mandry, Jose, Freire, Maria, Herrera Albornoz, Oscarina, Desai, Anant, Gandhi, Dayan, Rajan, Sibu, Raymond, Louis, Posada, Jorge, Garcia-Mayol, Luis, Gutierrez-Alsina, Rodolfo, Fernandez, Juan, Bruce, Kendaling, Cuellar, Juan, Ranz y Alvarez, Maria, Bartolacci, Ines, Pautasso, Mauro, Stoppa, Daniela, Riella, Miguel, Barbosa, Maria, Harcsa, Eleonora, Gulati, Yuvraj, Savalia, Denish, Khetan, Prakash, Sinha, Dhananjay, R, Niranjan, K, Srinivas, Pazos, Fabiola, Gacutan-Liwag, Aretha, Duszynska, Malgorzata, Antkowiak-Piatyszek, Karolina, Konieczny, Grzegorz, Sidorowicz-Bialynicka, Anna, Ciesiolkiewicz-Wojcik, Agnieszka, Dwojak, Marek, Szymkowiak, Katarzyna, Gorczyca-Siudak, Daria, Janik-Palazzolo, Marzena, Siudak, Lukasz, Opiela, Jaroslaw, Iwanow, Dariusz, Solkiewicz, Monika, Sipinska-Surzynska, Malgorzata, Olszanecka - Glinianowicz, Magdalena, Rozmilowska, Izabela, Trokis, Julian, Prozesky, Hans, Burgess, Lesley, Cyster, Henry, Jordaan, Jurie, Mohamed, Hawa, Naude, Christina, Sitsila, Thembie, Mehta, Arvind, Mocherla, Bharat, Lee, Sungchun, Boren, Kenneth, Rudolph, Lance, Benjamin, Sabrina, Sugimoto, Danny, Hammoud, Jamal, Bakleh, Muhammad, Hashish, Yaseen, Da Costa, Jonathan, Gold, Marina, Majul, Claudio, Buscema, Juan, Gatto, Maria, Lombardi, Facundo, Paez, Olga, Puleio, Pablo, Alvarisqueta, Andrés, Pajon, Vanessa, Suarez, Gabriel, Hernandez Gauna, Adrian, Pereyra, Alejandro, Reig, Moira, Gelersztein, Elizabeth, Campestri, Gina, Gonzalez Santos, Maria, Sambresqui, Julieta, Catalano, Gustavo, Igarzabal, Cecilia, Vallejos, Augusto, Escobari, Claudio, Marchetto, Rocio, Chahin, Mariano, Aguilera, Andrea, Comes, Ana, Rodriguez Segade, Silvia, Baccaro, Claudia, Larrieu Lacoste, María Verónica, Saurral, Ruben, Cristino, Alberto, Dran, Dario, Koretzky, Martin, Ponti, Juan, Porto, Alejandro, Tenaglia, Yasmin, Maldonado, Natacha, Bertollo, Natalia, Van Perdeck, Verónica, Lopau, Kai, Wanner, Christoph, Berfelo, Florieke, Contzen, Christel, Arbi, Abdulwahab, Lee-Barkey, Young Hee, Maciejewska, Aleksandra, Arelin, Katrin, Haller, Hermann, Kaufeld, Jessica, Schmidt-Ott, Kai, Heinrichs, Sven, Krüger, Thilo, Gebauer, Chris, Paliege, Alexander, Henkel, Elena, Axthelm, Christoph, Derwahl, Karl-Michael, Trevisan, Roberto, Bellante, Rosalia, Borrella, Nicolò, Corsi, Anna, Gesualdo, Loreto, Ardillo, Teodora, Ficarella, Maria, Fikry, Sameh, Mazza, Giuseppe, Poirier, Lysane, Bajaj, Harpreet, Hatziagelaki, Erifili, Katopodis, Sokratis, Katsoudas, Spiros, Yamaura, Shuichi, Shikano, Tsutomu, Tosaki, Takahiro, Miho, Otoya, Tachibana, Naoki, Yumita, Wataru, Kado, Hiroshi, Villarreal Martinez, Jesus, Soto Miranda, Ernesto, Gonzalez Rodriguez, David, Panelo, Araceli, Santos, Telma, Birne, Rita, Branco, Patrícia, Martins, Ana, Mateus, Catarina, Teixeira e Costa, Fernando, Barreto, Sara, Silva Costa, Joana, Ferrer, Francisco, Silva, Joana, Awad, Ahmed, Khaleel, Shatha, Lustig, Ryan, Maharjan, Gajendra, Moya, Jaynier, Johnsingh, Amit, Acosta, Idalia, Newman, George, Buckle, Anita, and Hendon, Kendra

Abstract

Excess aldosterone accelerates chronic kidney disease progression. This phase 2 clinical trial assessed BI 690517, an aldosterone synthase inhibitor, for efficacy, safety, and dose selection.

Published
2024
Full Text
View/download PDF

26. Feasibility of dynamic CT-based adenosine stress myocardial perfusion imaging to detect and differentiate ischemic and infarcted myocardium in an large experimental porcine animal model

Author

Bamberg, Fabian, Hinkel, Rabea, Marcus, Roy P., Baloch, Elisabeth, Hildebrandt, Kristof, Schwarz, Florian, Hetterich, Holger, Sandner, Torleif A., Schlett, Christopher L., Ebersberger, Ullrich, Kupatt, Christian, Hoffmann, Udo, Reiser, Maximilian F., Theisen, Daniel, and Nikolaou, Konstantin

Published
2014
Full Text
View/download PDF

32. Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data

Author

Haase, Robert, Schlattmann, Peter, Gueret, Pascal, Andreini, Daniele, Pontone, Gianluca, Alkadhi, Hatem, Hausleiter, Jörg, Garcia, Mario J, Leschka, Sebastian, Meijboom, Willem B, Zimmermann, Elke, Gerber, Bernhard, Schoepf, U Joseph, Shabestari, Abbas A, Nørgaard, Bjarne L, Meijs, Matthijs F L, Sato, Akira, Ovrehus, Kristian A, Diederichsen, Axel C P, Jenkins, Shona M M, Knuuti, Juhani, Hamdan, Ashraf, Halvorsen, Bjørn A, Mendoza-Rodriguez, Vladimir, Rochitte, Carlos E, Rixe, Johannes, Wan, Yung Liang, Langer, Christoph, Bettencourt, Nuno, Martuscelli, Eugenio, Ghostine, Said, Buechel, Ronny R, Nikolaou, Konstantin, Mickley, Hans, Yang, Lin, Zhang, Zhaqoi, Chen, Marcus Y, Halon, David A, Rief, Matthias, Sun, Kai, Hirt-Moch, Beatrice, Niinuma, Hiroyuki, Marcus, Roy P, Muraglia, Simone, Jakamy, Réda, Chow, Benjamin J, Kaufmann, Philipp A, Tardif, Jean-Claude, Nomura, Cesar, Kofoed, Klaus F, Laissy, Jean-Pierre, Arbab-Zadeh, Armin, Kitagawa, Kakuya, Laham, Roger, Jinzaki, Masahiro, Hoe, John, Rybicki, Frank J, Scholte, Arthur, Paul, Narinder, Tan, Swee Y, Yoshioka, Kunihiro, Röhle, Robert, Schuetz, Georg M, Schueler, Sabine, Coenen, Maria H, Wieske, Viktoria, Achenbach, Stephan, Budoff, Matthew J, Laule, Michael, Newby, David E, Dewey, Marc, COME-CCT Consortium, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, University of Zurich, and Cardiology

Subjects
Computed Tomography Angiography, stable chest pain, ACCURACY, Coronary Vessels/diagnostic imaging, Settore MED/11 - Malattie dell'Apparato Cardiovascolare, Coronary Artery Disease, 2700 General Medicine, 030204 cardiovascular system & hematology, Chest pain, BIVARIATE METAANALYSIS, Coronary artery disease, Angina, 0302 clinical medicine, Positive predicative value, Medicine, 030212 general & internal medicine, SPECIFICITY, Computed tomography angiography, Computed Tomography Angiography/methods, medicine.diagnostic_test, 10042 Clinic for Diagnostic and Interventional Radiology, obstructive coronary artery disease, General Medicine, Coronary Vessels, 3. Good health, PREVALENCE, Pre- and post-test probability, Predictive value of tests, Radiology, medicine.symptom, SENSITIVITY, INTERVENTIONS, Coronary Artery Disease/complications, medicine.medical_specialty, OF-CARDIOLOGY FOUNDATION, 610 Medicine & health, computed tomography angiography (Englisch), AMERICAN-COLLEGE, Angina Pectoris, 03 medical and health sciences, Predictive Value of Tests, MANAGEMENT, Humans, cardiovascular diseases, Probability, CTA, business.industry, Research, Angina Pectoris/diagnostic imaging, 10181 Clinic for Nuclear Medicine, PERFORMANCE, medicine.disease, Confidence interval, Feasibility Studies, business
Abstract

Objective To determine whether coronary computed tomography angiography (CTA) should be performed in patients with any clinical probability of coronary artery disease (CAD), and whether the diagnostic performance differs between subgroups of patients. Design Prospectively designed meta-analysis of individual patient data from prospective diagnostic accuracy studies. Data sources Medline, Embase, and Web of Science for published studies. Unpublished studies were identified via direct contact with participating investigators. Eligibility criteria for selecting studies Prospective diagnostic accuracy studies that compared coronary CTA with coronary angiography as the reference standard, using at least a 50% diameter reduction as a cutoff value for obstructive CAD. All patients needed to have a clinical indication for coronary angiography due to suspected CAD, and both tests had to be performed in all patients. Results had to be provided using 2×2 or 3×2 cross tabulations for the comparison of CTA with coronary angiography. Primary outcomes were the positive and negative predictive values of CTA as a function of clinical pretest probability of obstructive CAD, analysed by a generalised linear mixed model; calculations were performed including and excluding non-diagnostic CTA results. The no-treat/treat threshold model was used to determine the range of appropriate pretest probabilities for CTA. The threshold model was based on obtained post-test probabilities of less than 15% in case of negative CTA and above 50% in case of positive CTA. Sex, angina pectoris type, age, and number of computed tomography detector rows were used as clinical variables to analyse the diagnostic performance in relevant subgroups. Results Individual patient data from 5332 patients from 65 prospective diagnostic accuracy studies were retrieved. For a pretest probability range of 7-67%, the treat threshold of more than 50% and the no-treat threshold of less than 15% post-test probability were obtained using CTA. At a pretest probability of 7%, the positive predictive value of CTA was 50.9% (95% confidence interval 43.3% to 57.7%) and the negative predictive value of CTA was 97.8% (96.4% to 98.7%); corresponding values at a pretest probability of 67% were 82.7% (78.3% to 86.2%) and 85.0% (80.2% to 88.9%), respectively. The overall sensitivity of CTA was 95.2% (92.6% to 96.9%) and the specificity was 79.2% (74.9% to 82.9%). CTA using more than 64 detector rows was associated with a higher empirical sensitivity than CTA using up to 64 rows (93.4% v 86.5%, P=0.002) and specificity (84.4% v 72.6%, Pv 0.907 (0.897 to 0.916), Pv all other age groups) and was not significantly influenced by angina pectoris type (typical angina 0.895 (0.873 to 0.917), atypical angina 0.898 (0.884 to 0.913), non-anginal chest pain 0.884 (0.870 to 0.899), other chest discomfort 0.915 (0.897 to 0.934)). Conclusions In a no-treat/treat threshold model, the diagnosis of obstructive CAD using coronary CTA in patients with stable chest pain was most accurate when the clinical pretest probability was between 7% and 67%. Performance of CTA was not influenced by the angina pectoris type and was slightly higher in men and lower in older patients. Systematic review registration PROSPERO CRD42012002780.

Published
2019
Full Text
View/download PDF

33. Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data

Author

Haase, Robert, primary, Schlattmann, Peter, additional, Gueret, Pascal, additional, Andreini, Daniele, additional, Pontone, Gianluca, additional, Alkadhi, Hatem, additional, Hausleiter, Jörg, additional, Garcia, Mario J, additional, Leschka, Sebastian, additional, Meijboom, Willem B, additional, Zimmermann, Elke, additional, Gerber, Bernhard, additional, Schoepf, U Joseph, additional, Shabestari, Abbas A, additional, Nørgaard, Bjarne L, additional, Meijs, Matthijs F L, additional, Sato, Akira, additional, Ovrehus, Kristian A, additional, Diederichsen, Axel C P, additional, Jenkins, Shona M M, additional, Knuuti, Juhani, additional, Hamdan, Ashraf, additional, Halvorsen, Bjørn A, additional, Mendoza-Rodriguez, Vladimir, additional, Rochitte, Carlos E, additional, Rixe, Johannes, additional, Wan, Yung Liang, additional, Langer, Christoph, additional, Bettencourt, Nuno, additional, Martuscelli, Eugenio, additional, Ghostine, Said, additional, Buechel, Ronny R, additional, Nikolaou, Konstantin, additional, Mickley, Hans, additional, Yang, Lin, additional, Zhang, Zhaqoi, additional, Chen, Marcus Y, additional, Halon, David A, additional, Rief, Matthias, additional, Sun, Kai, additional, Hirt-Moch, Beatrice, additional, Niinuma, Hiroyuki, additional, Marcus, Roy P, additional, Muraglia, Simone, additional, Jakamy, Réda, additional, Chow, Benjamin J, additional, Kaufmann, Philipp A, additional, Tardif, Jean-Claude, additional, Nomura, Cesar, additional, Kofoed, Klaus F, additional, Laissy, Jean-Pierre, additional, Arbab-Zadeh, Armin, additional, Kitagawa, Kakuya, additional, Laham, Roger, additional, Jinzaki, Masahiro, additional, Hoe, John, additional, Rybicki, Frank J, additional, Scholte, Arthur, additional, Paul, Narinder, additional, Tan, Swee Y, additional, Yoshioka, Kunihiro, additional, Röhle, Robert, additional, Schuetz, Georg M, additional, Schueler, Sabine, additional, Coenen, Maria H, additional, Wieske, Viktoria, additional, Achenbach, Stephan, additional, Budoff, Matthew J, additional, Laule, Michael, additional, Newby, David E, additional, and Dewey, Marc, additional

Published
2019
Full Text
View/download PDF

34. Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data.

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, Haase, Robert, Schlattmann, Peter, Gueret, Pascal, Andreini, Daniele, Pontone, Gianluca, Alkadhi, Hatem, Hausleiter, Jörg, Garcia, Mario J, Leschka, Sebastian, Meijboom, Willem B, Zimmermann, Elke, Gerber, Bernhard, Schoepf, U Joseph, Shabestari, Abbas A, Nørgaard, Bjarne L, Meijs, Matthijs F L, Sato, Akira, Ovrehus, Kristian A, Diederichsen, Axel C P, Jenkins, Shona M M, Knuuti, Juhani, Hamdan, Ashraf, Halvorsen, Bjørn A, Mendoza-Rodriguez, Vladimir, Rochitte, Carlos E, Rixe, Johannes, Wan, Yung Liang, Langer, Christoph, Bettencourt, Nuno, Martuscelli, Eugenio, Ghostine, Said, Buechel, Ronny R, Nikolaou, Konstantin, Mickley, Hans, Yang, Lin, Zhang, Zhaqoi, Chen, Marcus Y, Halon, David A, Rief, Matthias, Sun, Kai, Hirt-Moch, Beatrice, Niinuma, Hiroyuki, Marcus, Roy P, Muraglia, Simone, Jakamy, Réda, Chow, Benjamin J, Kaufmann, Philipp A, Tardif, Jean-Claude, Nomura, Cesar, Kofoed, Klaus F, Laissy, Jean-Pierre, Arbab-Zadeh, Armin, Kitagawa, Kakuya, Laham, Roger, Jinzaki, Masahiro, Hoe, John, Rybicki, Frank J, Scholte, Arthur, Paul, Narinder, Tan, Swee Y, Yoshioka, Kunihiro, Röhle, Robert, Schuetz, Georg M, Schueler, Sabine, Coenen, Maria H, Wieske, Viktoria, Achenbach, Stephan, Budoff, Matthew J, Laule, Michael, Newby, David E, Dewey, Marc, COME-CCT Consortium, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, Haase, Robert, Schlattmann, Peter, Gueret, Pascal, Andreini, Daniele, Pontone, Gianluca, Alkadhi, Hatem, Hausleiter, Jörg, Garcia, Mario J, Leschka, Sebastian, Meijboom, Willem B, Zimmermann, Elke, Gerber, Bernhard, Schoepf, U Joseph, Shabestari, Abbas A, Nørgaard, Bjarne L, Meijs, Matthijs F L, Sato, Akira, Ovrehus, Kristian A, Diederichsen, Axel C P, Jenkins, Shona M M, Knuuti, Juhani, Hamdan, Ashraf, Halvorsen, Bjørn A, Mendoza-Rodriguez, Vladimir, Rochitte, Carlos E, Rixe, Johannes, Wan, Yung Liang, Langer, Christoph, Bettencourt, Nuno, Martuscelli, Eugenio, Ghostine, Said, Buechel, Ronny R, Nikolaou, Konstantin, Mickley, Hans, Yang, Lin, Zhang, Zhaqoi, Chen, Marcus Y, Halon, David A, Rief, Matthias, Sun, Kai, Hirt-Moch, Beatrice, Niinuma, Hiroyuki, Marcus, Roy P, Muraglia, Simone, Jakamy, Réda, Chow, Benjamin J, Kaufmann, Philipp A, Tardif, Jean-Claude, Nomura, Cesar, Kofoed, Klaus F, Laissy, Jean-Pierre, Arbab-Zadeh, Armin, Kitagawa, Kakuya, Laham, Roger, Jinzaki, Masahiro, Hoe, John, Rybicki, Frank J, Scholte, Arthur, Paul, Narinder, Tan, Swee Y, Yoshioka, Kunihiro, Röhle, Robert, Schuetz, Georg M, Schueler, Sabine, Coenen, Maria H, Wieske, Viktoria, Achenbach, Stephan, Budoff, Matthew J, Laule, Michael, Newby, David E, Dewey, Marc, and COME-CCT Consortium

Abstract

OBJECTIVE: To determine whether coronary computed tomography angiography (CTA) should be performed in patients with any clinical probability of coronary artery disease (CAD), and whether the diagnostic performance differs between subgroups of patients. DESIGN: Prospectively designed meta-analysis of individual patient data from prospective diagnostic accuracy studies. DATA SOURCES: Medline, Embase, and Web of Science for published studies. Unpublished studies were identified via direct contact with participating investigators. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Prospective diagnostic accuracy studies that compared coronary CTA with coronary angiography as the reference standard, using at least a 50% diameter reduction as a cutoff value for obstructive CAD. All patients needed to have a clinical indication for coronary angiography due to suspected CAD, and both tests had to be performed in all patients. Results had to be provided using 2×2 or 3×2 cross tabulations for the comparison of CTA with coronary angiography. Primary outcomes were the positive and negative predictive values of CTA as a function of clinical pretest probability of obstructive CAD, analysed by a generalised linear mixed model; calculations were performed including and excluding non-diagnostic CTA results. The no-treat/treat threshold model was used to determine the range of appropriate pretest probabilities for CTA. The threshold model was based on obtained post-test probabilities of less than 15% in case of negative CTA and above 50% in case of positive CTA. Sex, angina pectoris type, age, and number of computed tomography detector rows were used as clinical variables to analyse the diagnostic performance in relevant subgroups. RESULTS: Individual patient data from 5332 patients from 65 prospective diagnostic accuracy studies were retrieved. For a pretest probability range of 7-67%, the treat threshold of more than 50% and the no-treat threshold of less than 15% post-test probability we

Published
2019

35. Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups:Meta-analysis of individual patient data

Author

Haase, Robert, Schlattmann, Peter, Gueret, Pascal, Andreini, Daniele, Pontone, Gianluca, Alkadhi, Hatem, Hausleiter, Jörg, Garcia, Mario J., Leschka, Sebastian, Meijboom, Willem B., Zimmermann, Elke, Gerber, Bernhard, Schoepf, U. Joseph, Shabestari, Abbas A., Nørgaard, Bjarne L., Meijs, Matthijs F.L., Sato, Akira, Ovrehus, Kristian A., Diederichsen, Axel C.P., Jenkins, Shona M.M., Knuuti, Juhani, Hamdan, Ashraf, Halvorsen, Bjørn A., Mendoza-Rodriguez, Vladimir, Rochitte, Carlos E., Rixe, Johannes, Wan, Yung Liang, Langer, Christoph, Bettencourt, Nuno, Martuscelli, Eugenio, Ghostine, Said, Buechel, Ronny R., Nikolaou, Konstantin, Mickley, Hans, Yang, Lin, Zhang, Zhaqoi, Chen, Marcus Y., Halon, David A., Rief, Matthias, Sun, Kai, Hirt-Moch, Beatrice, Niinuma, Hiroyuki, Marcus, Roy P., Muraglia, Simone, Jakamy, Réda, Chow, Benjamin J., Kaufmann, Philipp A., Tardif, Jean Claude, Nomura, Cesar, Kofoed, Klaus F., Laissy, Jean Pierre, Arbab-Zadeh, Armin, Kitagawa, Kakuya, Laham, Roger, Jinzaki, Masahiro, Hoe, John, Rybicki, Frank J., Scholte, Arthur, Paul, Narinder, Tan, Swee Y., Yoshioka, Kunihiro, Röhle, Robert, Schuetz, Georg M., Schueler, Sabine, Coenen, Maria H., Wieske, Viktoria, Achenbach, Stephan, Budoff, Matthew J., Laule, Michael, Newby, David E., Dewey, Marc, Haase, Robert, Schlattmann, Peter, Gueret, Pascal, Andreini, Daniele, Pontone, Gianluca, Alkadhi, Hatem, Hausleiter, Jörg, Garcia, Mario J., Leschka, Sebastian, Meijboom, Willem B., Zimmermann, Elke, Gerber, Bernhard, Schoepf, U. Joseph, Shabestari, Abbas A., Nørgaard, Bjarne L., Meijs, Matthijs F.L., Sato, Akira, Ovrehus, Kristian A., Diederichsen, Axel C.P., Jenkins, Shona M.M., Knuuti, Juhani, Hamdan, Ashraf, Halvorsen, Bjørn A., Mendoza-Rodriguez, Vladimir, Rochitte, Carlos E., Rixe, Johannes, Wan, Yung Liang, Langer, Christoph, Bettencourt, Nuno, Martuscelli, Eugenio, Ghostine, Said, Buechel, Ronny R., Nikolaou, Konstantin, Mickley, Hans, Yang, Lin, Zhang, Zhaqoi, Chen, Marcus Y., Halon, David A., Rief, Matthias, Sun, Kai, Hirt-Moch, Beatrice, Niinuma, Hiroyuki, Marcus, Roy P., Muraglia, Simone, Jakamy, Réda, Chow, Benjamin J., Kaufmann, Philipp A., Tardif, Jean Claude, Nomura, Cesar, Kofoed, Klaus F., Laissy, Jean Pierre, Arbab-Zadeh, Armin, Kitagawa, Kakuya, Laham, Roger, Jinzaki, Masahiro, Hoe, John, Rybicki, Frank J., Scholte, Arthur, Paul, Narinder, Tan, Swee Y., Yoshioka, Kunihiro, Röhle, Robert, Schuetz, Georg M., Schueler, Sabine, Coenen, Maria H., Wieske, Viktoria, Achenbach, Stephan, Budoff, Matthew J., Laule, Michael, Newby, David E., and Dewey, Marc

Abstract

Objective To determine whether coronary computed tomography angiography (CTA) should be performed in patients with any clinical probability of coronary artery disease (CAD), and whether the diagnostic performance differs between subgroups of patients. Design Prospectively designed meta-analysis of individual patient data from prospective diagnostic accuracy studies. Data sources Medline, Embase, and Web of Science for published studies. Unpublished studies were identified via direct contact with participating investigators. Eligibility criteria for selecting studies Prospective diagnostic accuracy studies that compared coronary CTA with coronary angiography as the reference standard, using at least a 50% diameter reduction as a cutoff value for obstructive CAD. All patients needed to have a clinical indication for coronary angiography due to suspected CAD, and both tests had to be performed in all patients. Results had to be provided using 2×2 or 3×2 cross tabulations for the comparison of CTA with coronary angiography. Primary outcomes were the positive and negative predictive values of CTA as a function of clinical pretest probability of obstructive CAD, analysed by a generalised linear mixed model; calculations were performed including and excluding non-diagnostic CTA results. The no-treat/treat threshold model was used to determine the range of appropriate pretest probabilities for CTA. The threshold model was based on obtained post-test probabilities of less than 15% in case of negative CTA and above 50% in case of positive CTA. Sex, angina pectoris type, age, and number of computed tomography detector rows were used as clinical variables to analyse the diagnostic performance in relevant subgroups. Results Individual patient data from 5332 patients from 65 prospective diagnostic accuracy studies were retrieved. For a pretest probability range of 7-67%, the treat threshold of more than 50% and the no-treat threshold of less than 15% post-test probability were

Published
2019

39. Global Quantification of Left Ventricular Myocardial Perfusion at Dynamic CT: Feasibility in a Multicenter Patient Population

Author

Meinel, Felix G., primary, Ebersberger, Ullrich, additional, Schoepf, U. Joseph, additional, Lo, Gladys G., additional, Choe, Yeon Hyeon, additional, Wang, Yining, additional, Maivelett, Jordan A., additional, Krazinski, Aleksander W., additional, Marcus, Roy P., additional, Bamberg, Fabian, additional, and De Cecco, Carlo Nicola, additional

Published
2014
Full Text
View/download PDF

41. Individual patient data meta-analysis for the clinical assessment of coronary computed tomography angiography: protocol of the Collaborative Meta-Analysis of Cardiac CT (CoMe-CCT).

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, Schuetz, Georg M, Schlattmann, Peter, Achenbach, Stephan, Budoff, Matthew, Garcia, Mario J, Roehle, Robert, Pontone, Gianluca, Meijboom, Willem Bob, Andreini, Daniele, Alkadhi, Hatem, Honoris, Lily, Bettencourt, Nuno, Hausleiter, Jörg, Leschka, Sebastian, Gerber, Bernhard, Meijs, Matthijs Fl, Shabestari, Abbas Arjmand, Sato, Akira, Zimmermann, Elke, Schoepf, Uwe J, Diederichsen, Axel, Halon, David A, Mendoza-Rodriguez, Vladimir, Hamdan, Ashraf, Nørgaard, Bjarne L, Brodoefel, Harald, Ovrehus, Kristian A, Jenkins, Shona Mm, Halvorsen, Bjørn A, Rixe, Johannes, Sheikh, Mehraj, Langer, Christoph, Martuscelli, Eugenio, Romagnoli, Andrea, Scholte, Arthur Jha, Marcus, Roy P, Ulimoen, Geir R, Nieman, Koen, Mickley, Hans, Nikolaou, Konstantin, Tardif, Jean-Claude, Johnson, Thorsten Rc, Muraglia, Simone, Chow, Benjamin Jw, Maintz, David, Laule, Michael, Dewey, Marc, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, Schuetz, Georg M, Schlattmann, Peter, Achenbach, Stephan, Budoff, Matthew, Garcia, Mario J, Roehle, Robert, Pontone, Gianluca, Meijboom, Willem Bob, Andreini, Daniele, Alkadhi, Hatem, Honoris, Lily, Bettencourt, Nuno, Hausleiter, Jörg, Leschka, Sebastian, Gerber, Bernhard, Meijs, Matthijs Fl, Shabestari, Abbas Arjmand, Sato, Akira, Zimmermann, Elke, Schoepf, Uwe J, Diederichsen, Axel, Halon, David A, Mendoza-Rodriguez, Vladimir, Hamdan, Ashraf, Nørgaard, Bjarne L, Brodoefel, Harald, Ovrehus, Kristian A, Jenkins, Shona Mm, Halvorsen, Bjørn A, Rixe, Johannes, Sheikh, Mehraj, Langer, Christoph, Martuscelli, Eugenio, Romagnoli, Andrea, Scholte, Arthur Jha, Marcus, Roy P, Ulimoen, Geir R, Nieman, Koen, Mickley, Hans, Nikolaou, Konstantin, Tardif, Jean-Claude, Johnson, Thorsten Rc, Muraglia, Simone, Chow, Benjamin Jw, Maintz, David, Laule, Michael, and Dewey, Marc

Abstract

This collaborative individual patient data meta-analysis should provide answers to the pivotal question of which patients benefit most from noninvasive coronary computed tomography angiography and thus help to adequately select the right patients for this test.

Published
2013

42. Diabetes Mellitus: Long-term Prognostic Value of Whole-Body MR Imaging for the Occurrence of Cardiac and Cerebrovascular Events

Author

Bamberg, Fabian, primary, Parhofer, Klaus G., additional, Lochner, Elena, additional, Marcus, Roy P., additional, Theisen, Daniel, additional, Findeisen, Hannes M., additional, Hoffmann, Udo, additional, Schönberg, Stefan O., additional, Schlett, Christopher L., additional, Reiser, Maximilian F., additional, and Weckbach, Sabine, additional

Published
2013
Full Text
View/download PDF

43. Dynamic CT myocardial perfusion imaging: performance of 3D semi-automated evaluation software

Author

Ebersberger, Ullrich, primary, Marcus, Roy P., additional, Schoepf, U. Joseph, additional, Lo, Gladys G., additional, Wang, Yining, additional, Blanke, Philipp, additional, Geyer, Lucas L., additional, Gray, J. Cranston, additional, McQuiston, Andrew D., additional, Cho, Young Jun, additional, Scheuering, Michael, additional, Canstein, Christian, additional, Nikolaou, Konstantin, additional, Hoffmann, Ellen, additional, and Bamberg, Fabian, additional

Published
2013
Full Text
View/download PDF

44. Recent Scientific Evidence and Technical Developments in Cardiovascular Computed Tomography.

Author

Marcus, Roy, Ruff, Christer, Burgstahler, Christof, Notohamiprodjo, Mike, Nikolaou, Konstantin, Geisler, Tobias, Schroeder, Stephen, and Bamberg, Fabian

Abstract

Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
Full Text
View/download PDF

45. Imaging Evaluation of Acute Chest Pain

Author

Bamberg, Fabian, primary, Marcus, Roy P., additional, Schlett, Christopher L., additional, Schoepf, U. Joseph, additional, Johnson, Thorsten R., additional, Nance, John W., additional, Hoffmann, Udo, additional, Reiser, Maximilian F., additional, and Nikolaou, Konstantin, additional

Published
2012
Full Text
View/download PDF

46. Detection of Hemodynamically Significant Coronary Artery Stenosis: Incremental Diagnostic Value of Dynamic CT-based Myocardial Perfusion Imaging

Author

Bamberg, Fabian, primary, Becker, Alexander, additional, Schwarz, Florian, additional, Marcus, Roy P., additional, Greif, Martin, additional, von Ziegler, Franz, additional, Blankstein, Ron, additional, Hoffmann, Udo, additional, Sommer, Wieland H., additional, Hoffmann, Verena S., additional, Johnson, Thorsten R. C., additional, Becker, Hans-Christoph R., additional, Wintersperger, Bernd J., additional, Reiser, Maximilian F., additional, and Nikolaou, Konstantin, additional

Published
2011
Full Text
View/download PDF

48. Evidencia científica reciente y avances técnicos en la tomografía computarizada cardiovascular

Author

Marcus, Roy, Ruff, Christer, Burgstahler, Christof, Notohamiprodjo, Mike, Nikolaou, Konstantin, Geisler, Tobias, Schroeder, Stephen, and Bamberg, Fabian

Abstract

En los últimos años, la coronariografía (o angiografía coronaria) por tomografía computarizada se ha asentado cada vez más como una modalidad diagnóstica segura y no invasiva para la evaluación de la antomía del árbol arterial coronario, que aporta ventajas diagnósticas, en especial para pacientes con probabilidad pretest baja o intermedia de la enfermedad. Actualmente hay cada vez más evidencia de grandes ensayos aleatorizados sobre la influencia diagnóstica de la angiotomografía computarizada en el manejo de los pacientes con síndromes de dolor torácico agudo y crónico. Al mismo tiempo, los avances técnicos han reducido sustancialmente los efectos adversos y los factores limitantes, como la exposición a la radiación, la cantidad de medio de contraste yodado que se aplica y el tiempo de exploración, lo cual la hace apropiada para aplicaciones clínicas más amplias. En este trabajo se revisan los avances más recientes en la tecnología de la tomografía computarizada y se describe la evidencia científica existente sobre el uso de la angiotomografía computarizada cardiaca en la evaluación de los pacientes con síndromes de dolor torácico agudo y crónico.

Published
2016
Full Text
View/download PDF

49. Accuracy of Dynamic Computed Tomography Adenosine Stress Myocardial Perfusion Imaging in Estimating Myocardial Blood Flow at Various Degrees of Coronary Artery Stenosis Using a Porcine Animal Model

Author

Bamberg, Fabian, Hinkel, Rabea, Schwarz, Florian, Sandner, Torleif A., Baloch, Elisabeth, Marcus, Roy, Becker, Alexander, Kupatt, Christian, Wintersperger, Bernd J., Johnson, Thorsten R., Theisen, Daniel, Klotz, Ernst, Reiser, Maximilian F., and Nikolaou, Konstantin

Abstract

To determine the accuracy of computed tomography (CT) dynamic stress myocardial perfusion imaging to estimate myocardial blood flow (MBF) in a porcine animal model with variable degrees of induced coronary artery stenosis in comparison with microsphere-derived MBF.

Published
2012
Full Text
View/download PDF

50. Protein Intake Seems to Respond to Increases in Kt/V despite Baseline Kt/V Greater than 1.2

Author

Marcus, Roy G., Cohl, Edith, and Uribarri, Jaime

Abstract

The nutritional status is a strong predictor of outcome in hemodialysis patients. Adequate delivery of dialysis is necessary for hemodialysis patients to maintain their protein nutrition. In general, a single-pool Kt/V of 1.2 has been considered adequate dialysis. We recently decided to maximize the blood flow during hemodialysis in all of our patients; this enabled us to increase the dose of delivered dialysis in those patients who were not initially utilizing their maximum blood flow. There were 18 patients who already received a Kt/V greater than 1.2. We were able to increase Kt/V even further in 10 of them, resulting in a significant increase in nPCR and a trend to increase serum albumin over the next 6 months of follow-up. The mean normalized protein catabolic rate (nPCR) and serum albumin remained unchanged in the remaining 8 patients whose Kt/V could not be increased. Our data provide evidence that protein intake in hemodialysis patients will increase with an increase in delivered dialysis above the level generally considered to be adequate.

Published
1999
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results