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1. Gastrointestinal and Nutritional Disorders

Author

Scherbakova, Ioana, Chen, Royce W. S., Marcus, Dennis M., Rustgi, Anil, Sundstrom, Jeffrey M., Section editor, Quillen, David A., Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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3. Clinical Performance of Semi-Automated Spectral-Domain Optical Coherence Tomography Angiography.

Author

Alibhai, A. Yasin, Durbin, Mary K., Hou, Huiyuan, Sadda, Srinivas R., Marcus, Dennis M., You, Timothy T., El-Nimri, Nevin W., Huebschmann, Lukas, and Waheed, Nadia K.

Abstract

Background/Objectives: To evaluate the clinical performance of two optical coherence tomography angiography (OCTA) devices, including a semi-automated device, with respect to image quality and pathology detection, with fluorescein angiography (FA) and indocyanine green angiography (ICGA) serving as the reference standards. Methods: In this prospective cross-sectional study, normal eyes and those with various retinal and choroidal pathologies were enrolled and underwent OCTA scanning using semi-automated 3D OCT-1 Maestro2 and Cirrus™ HD-OCT 5000 devices, as well as FA/ICGA imaging. OCTA scans and FA/ICGA images were independently graded for image quality and the visibility of prespecified anatomic vascular features, along with the presence or absence of pathology on the OCTA scans and the FA/ICGA images (within regions corresponding to the OCTA scan areas). Positive percent agreement (PPA), defined as the proportion of eyes in which the OCTA demonstrated pathology when the corresponding FA/ICGA showed pathology, and negative percent agreement (NPA), defined as the proportion of eyes in which the OCTA showed no pathology when the FA/ICGA also showed no pathology, were calculated. Results: In total, 38 normal eyes and 86 pathologic eyes were enrolled in the study. The majority of images for both devices were considered clinically useful. The PPA and NPA were high for both devices, indicating a good ability to identify disease when present and to rule it out when not present. Conclusions: The findings of this study suggest that the semi-automated Maestro2 and Cirrus have comparably good clinical performance, particularly with regard to accuracy when identifying vascular pathologies. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Review of Suprachoroidal Delivery and its Application in Small Molecule Therapy.

Author

Qin, Luke G., Kasetty, Venkatkrish M., Espinosa-Heidmann, Diego, and Marcus, Dennis M.

Subjects
RETINAL diseases, SMALL molecules, DRUG bioavailability, DRUG delivery systems, STEROID drugs
Abstract

Therapies for retinal diseases have witnessed remarkable progress, particularly in the domain of drug delivery routes. Intravitreal injections have especially revolutionized the treatment landscape for various proliferative retinopathies. The emergence of suprachoroidal space as a novel drug delivery site is poised to overcome challenges seen in optimizing drug penetration, targeting, and bioavailability. This approach holds promise for delivering various agents, including steroids, anti-vascular endothelial growth factor molecules, gene vectors, and small molecules, with multiple clinical trials demonstrating this delivery method's potential to reduce treatment burdens and optimize visual outcomes. Particularly, small molecule therapy for retinal diseases finds ease of application through the suprachoroidal route in that small molecule agents have a wide range of targets in disease pathway, greater tissue penetration, and cost-effectiveness in production. The suprachoroidal administration of axitinib, a tyrosine kinase inhibitor, has shown promise in the OASIS trial for treating neovascular age-related macular degeneration. Integrin antagonists and plasma Kallikrein-kinin system inhibitors, also delivered suprachoroidally, exhibit targeted distribution and potential for long-acting therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Aflibercept Monotherapy or Bevacizumab First for Diabetic Macular Edema

Author

Jhaveri, Chirag D., primary, Glassman, Adam R., additional, Ferris, Frederick L., additional, Liu, Danni, additional, Maguire, Maureen G., additional, Allen, John B., additional, Baker, Carl W., additional, Browning, David, additional, Cunningham, Matthew A., additional, Friedman, Scott M., additional, Jampol, Lee M., additional, Marcus, Dennis M., additional, Martin, Daniel F., additional, Preston, Carin M., additional, Stockdale, Cynthia R., additional, and Sun, Jennifer K., additional

Published
2022
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16. Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial

Author

Gross, Jeffrey G., Glassman, Adam R., Jampol, Lee M., Inusah, Seidu, Aiello, Lloyd Paul, Antoszyk, Andrew N., Baker, Carl W., Berger, Brian B., Bressler, Neil M., Browning, David, Elman, Michael J., Ferris, Frederick L., III, Friedman, Scott M., Marcus, Dennis M., Melia, Michele, Stockdale, Cynthia R., Sun, Jennifer K., and Beck, Roy W.

Published
2015
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22. List of Contributors

Author

Abad, Juan-Carlos, primary, Abelson, Mark B, additional, Abramson, David H, additional, Acquadro, Martin A, additional, Adamis, Anthony P, additional, Adams, Wesley H, additional, Afshari, Natalie A, additional, Ai, Everett, additional, Aiello, Lloyd M, additional, Aiello, Lloyd P, additional, Akduman, Levent, additional, Albano, Marissa L, additional, Albert, Daniel M., additional, Alexandrou, Terry J, additional, Alfonso, Eduardo C, additional, Alié, Jorge L, additional, Alizadeh, Hassan, additional, Al Jadaan, Ibrahim A, additional, Al-Jastaneiah, Sabah, additional, Allen, Calliope E, additional, Allen, David, additional, Allen, Robert C, additional, Alm, Albert, additional, Al-Swailem, Samar, additional, Alt, Abigail K, additional, Altaweel, Michael M, additional, Anderson, Russell, additional, Andreoli, Christopher M, additional, Androudi, Sofia, additional, Ang, Leonard PK, additional, Anzaar, Fahd, additional, Apple, David J, additional, Arrigg, Claudia A, additional, Artal, Pablo, additional, Asbell, Penny, additional, Asdourian, George K, additional, Atebara, Neal, additional, Atmaca-Sonmez, Pelin, additional, Audo, Isabelle, additional, Auffarth, Gerd U, additional, Avery, Robin K, additional, Azar, Dimitri T, additional, Baker, Ann S, additional, Balles, Mark, additional, Barnes, Scott D, additional, Barnett, Donald M, additional, Barney, Neal P, additional, Barouch, Fina C, additional, Bartley, George B, additional, Barton, Jason JS, additional, Behlau, Irmgard, additional, Belda, Jose I, additional, Bennett, Jeffrey L, additional, Bennett, Timothy J, additional, Berdy, Gregg J, additional, Bernardino, Carlo Roberto, additional, Bernardino, Vitaliano, additional, Berson, Eliot L, additional, Bharadwaj, Amitabh, additional, Bhisitkul, Robert, additional, Bhui, Ravinder D, additional, Bilyk, Jurij, additional, Biousse, Valérie, additional, Bird, Alan C, additional, Blair, Norman Paul, additional, Blodi, Barbara A, additional, Blumenkranz, Mark S, additional, Boldt, H Culver, additional, Borchert, Mark S, additional, Borrillo, Luigi, additional, Borodic, Gary E, additional, Boruchoff, S Arthur, additional, Bose, Swaraj, additional, Boulton, Michael E, additional, Bowman, RW, additional, Bradley, Elizabeth A, additional, Brazitikos, Periklis D, additional, Breeze, Robert, additional, Bressler, Neil M, additional, Bressler, Susan B, additional, Brini, Alfred, additional, Budenz, Donald L, additional, Buffenn, Angela N, additional, Burk, Scott E, additional, Butrus, Salim, additional, Callanan, David, additional, Cameron, J Douglas, additional, Cantor, Louis B, additional, Cantore, William A, additional, Cantu-Dibildox, Jorge, additional, Casas, Victoria, additional, Casper, Miriam, additional, Casten, Robin J, additional, Catoira, Yara P, additional, Cavallerano, Jerry, additional, Chai, Samantha J, additional, Chalita, Maria R, additional, Chamberlain, Sherman M, additional, Chan, Audrey S, additional, Chan, Chi-Chao, additional, Chan, Paul, additional, Chapin, Matthew J, additional, Chapman, Karen L, additional, Chen, Eric, additional, Chen, Joe, additional, Chen, Julie A, additional, Chen, Teresa C, additional, Chen, Zhou, additional, Chévez-Barrios, Patricia, additional, Chew, Emily Y, additional, Chiang, Mark, additional, Chodosh, James, additional, Chong, Eva-Marie, additional, Chun, Denise, additional, Chylack, Leo T, additional, Ciardella, Antonio P, additional, Civan, Mortimer, additional, Clamen, Liane, additional, Clark, John I, additional, Cockerham, Glenn, additional, Cohen, Andre, additional, Cohen, Elisabeth J, additional, Colby, Kathryn A, additional, Coleman, Anne L, additional, Coleman, Hanna R, additional, Colin, Joseph, additional, Collier, J Michael, additional, Comer, Grant M, additional, Conlon, M Ronan, additional, Cooper, Kim E, additional, Corbett, James J, additional, Coma, Miguel C, additional, Cyrlin, Marshall N, additional, Dagi, Linda R, additional, Dahlgren, Matthew A, additional, Daley, Timothy J, additional, Da Mata, Andrea P, additional, Damato, Bertil, additional, D'Amico, Donald J, additional, Dana, Reza, additional, Danan-Husson, Aude, additional, Danesh-Meyer, Helen B, additional, Danis, Ronald P, additional, Darlington, Jason K, additional, Davidson, Stefanie L, additional, Davis, Janet L, additional, Davis, Elizabeth A, additional, de la Cruz, Jose J, additional, de la Garza, Adam G, additional, DeAngelis, Margaret M, additional, DeMartelaere, Sheri L, additional, Demer, Joseph L, additional, Dhaliwal, Avninder, additional, Dieckert, J Paul, additional, Do, Diana V, additional, Doane, Marshall G, additional, Dodds, Christopher, additional, Dohlman, Claes H, additional, Donati, Guy, additional, Donnenfeld, Eric D, additional, Drack, Arlene, additional, Dryja, Thaddeus P, additional, Dueker, David, additional, Duker, Jay S, additional, Dunbar, Jennifer A, additional, Dunn, James P, additional, Dupps, William J, additional, Durand, Marlene L, additional, Dutton, Jonathan J, additional, Eandi, Chiara M, additional, Edward, Deepak P, additional, Egan, Robert A, additional, Eichenbaum, David A, additional, Eklund, Susan E, additional, Engle, Elizabeth C, additional, Erickson, Kristine, additional, Esmaeli, Bita, additional, Fay, Aaron, additional, Feiner, Leonard, additional, Fekrat, Sharon, additional, Ferris, Frederick L, additional, Fine, Howard F, additional, Fletcher, Donald C, additional, Flikier, Paul, additional, Floyd, Richard P, additional, Flynn, Harry W, additional, Fong, Donald S, additional, Font, Ramon L, additional, Forbes, Brian JR, additional, Foroozan, Rod, additional, Foster, Bradley S, additional, Foster, C Stephen, additional, Foster, Jill A, additional, Foulks, Gary N, additional, Fountain, Tamara R, additional, Fox, Gregory M, additional, Freddo, Thomas F, additional, Freedman, Sharon F, additional, Freund, K Bailey, additional, Friberg, Thomas R, additional, Friedman, Alan H, additional, Friedman, David, additional, Friedman, Deborah I, additional, Friedman, Ephraim, additional, Fu, Arthur D, additional, Fulton, Anne B, additional, Galal, Ahmed, additional, Galetta, Steven, additional, Gallardo, Mark, additional, Gallie, Brenda, additional, Garner, Alec, additional, Garrity, James A, additional, Gatinel, Damien, additional, Gedde, Steven J, additional, Geist, Craig E, additional, Gerber, Steve, additional, Ghanem, Ramon C, additional, Gieser, Jon P, additional, Gilmore, Michael S, additional, Gimbel, Howard V, additional, Gipson, Ilene K, additional, Glover, Tyrone, additional, Goldberg, Robert A, additional, Goldenfeld, Mordechai, additional, Goldstein, Scott M, additional, Gomi, Cintia F, additional, Gong, Haiyan, additional, Gonzales, John A, additional, Goosey, John, additional, Gottlieb, Justin L, additional, Gould, Joshua, additional, Gragoudas, Evangelos S, additional, Granet, David B, additional, Greaney, Michael J, additional, Green, Daniel G, additional, Grehn, Franz, additional, Greiner, Jack V, additional, Greven, Craig M, additional, Griepentrog, Gregory J, additional, Groenewald, Carl, additional, Grosskreutz, Cynthia L, additional, Grover, Lori Latowski, additional, Gullapalli, Vamsi K, additional, Gulur, Padma, additional, Gunther, Jonathan, additional, Gupta, Manish, additional, Gupta, Mayank, additional, Guyer, David R, additional, Haivala, Darin R, additional, Haller, Julia A, additional, Halmagyi, GM, additional, Halperin, Lawrence S, additional, Hamdi, Islam M, additional, Hamilton, Steven R, additional, Hammersmith, Kristin M, additional, Han, Dennis P, additional, Hansen, Ronald M, additional, Harbour, J William, additional, Hariprasad, Seenu M, additional, Harissi-Dagher, Mona, additional, Hassan, Shirin E., additional, Hatton, Mark P, additional, Hawley, Pamela, additional, Hayashida, Yasutaka, additional, Heckenlively, John R, additional, Hedges, Thomas R, additional, Heggie, Alfred D, additional, Heher, Katrinka L, additional, Heier, Jeffrey S, additional, Hejtmancik, J Fielding, additional, Henderson, Bonnie A, additional, Hersh, Peter S, additional, Hidayat, Ahmed A, additional, Higginbotham, Eva Juliet, additional, Hirose, Tatsuo, additional, Ho, Allen C, additional, Ho, ThucAnh T, additional, Hogan, R Nick, additional, Holck, David E, additional, Holekamp, Nancy M, additional, Hovland, Peter G, additional, Hsu, Thomas C, additional, Hsu, William C, additional, Huang, Andrew JW, additional, Hughes, Mark S, additional, Hui, Jennifer, additional, Hunter, David G, additional, Huryn, Laryssa A, additional, Husain, Deeba, additional, Hyndiuk, Robert A, additional, Ip, Michael, additional, Jacobs, Brian J, additional, Jakobiec, Frederick A, additional, Jampol, Lee M, additional, Jensen, Harold G, additional, Ji, Fei, additional, Johnson, David L, additional, Johnson, Douglas H, additional, Johnson, Mark W, additional, Johnson, R Paul, additional, Johnson, Robert N, additional, Joos, Karen M, additional, Joyce, Nancy C, additional, Jumper, J Michael, additional, Jurkunas, Ula V., additional, Kahana, Alon, additional, Kahook, Malik Y, additional, Kanner, Elliott, additional, Kalwerisky, Kevin, additional, Kaplan, Henry J, additional, Karatza, Ekaterini C, additional, Kardon, Randy, additional, Katowitz, James A, additional, Katowitz, William R, additional, Kazlas, Melanie, additional, Keefe, Kelly S, additional, Kelley, Lara, additional, Kent, Charles J, additional, Kenyon, Kenneth R, additional, Khan, Bilal F, additional, Khan, Jemshed A, additional, Khan, Naheed W, additional, Khaw, Peng Tee, additional, Kherani, Femida, additional, Kim, Eva C, additional, Kim, Hee Joon, additional, Kim, Ivana K, additional, Kim, Jonathan W, additional, Kim, Rosa Y, additional, Kim, Stella K, additional, Kim, Tae-Im, additional, Klais, Christina M, additional, Klapper, Stephen R, additional, Klein, Barbara EK, additional, Kleinmann, Guy, additional, Klink, Thomas, additional, Klisovic, Dino D, additional, Klyce, Stephen D, additional, Kocaturk, Tolga, additional, Kohnen, Thomas, additional, Kojima, Takeshi, additional, Koller, Tobias, additional, Kostick, David A, additional, Kraut, Joel A, additional, Krishnan, Chandrasekharan, additional, Krueger, Ronald R, additional, Krug, Joseph H, additional, Krupsky, Sara, additional, Kuchtey, Rachel W, additional, Kurban, Ramsay S, additional, Kurz, Paul A, additional, Kuszak, JR, additional, Kwon, Young H, additional, Labbe, Thad A, additional, Lam, Deborah L, additional, Lamkin, Jeffrey C, additional, Lamping, Kathleen A, additional, Lane, Anne Marie, additional, Lane, Katherine A, additional, Lane, Keith J, additional, Lass, Jonathan H, additional, Lawrence, Mary G, additional, Lee, Andrew G, additional, Lee, Carol M, additional, Lee, Michael S, additional, Lee, Paul P, additional, Lee, William B, additional, Leibovitch, Igal, additional, Lemke, Bradley N, additional, Lemley, Craig A, additional, Leonardi, Andrea, additional, Lessell, Simmons, additional, Levin, Leonard A, additional, Levy-Clarke, Grace A, additional, Lew, Julie C, additional, Lewis, Craig, additional, Li, Wei, additional, Lim, Laurence S, additional, Lim, Lyndell L, additional, Lim, Wee-Kiak, additional, Liu, Grant T, additional, Loewenstein, John I, additional, Lott, McGregor N, additional, Lowry, Jonathan C, additional, Lyon, David B, additional, Lytle, Robert E, additional, MacCumber, Mathew, additional, Mackool, Bonnie T, additional, Madiwale, Nalini A, additional, Mah, Francis, additional, Mainster, Martin A, additional, Manning, Michael H, additional, Mansberger, Steven L, additional, Marc, Robert E, additional, Marchong, Mellone, additional, Marcus, Dennis M, additional, Mares, Julie A, additional, Marr, Brian P, additional, Martinez, Carlos E, additional, Massof, Robert W, additional, Matsumoto, Yukihiro, additional, Mattox, Cynthia, additional, Maus, Marlon, additional, McCabe, Cathleen M, additional, McCormick, Steven A, additional, McCrakken, Michael, additional, McCulley, James P, additional, McDermott, John A, additional, McDonald, H Richard, additional, McDonald, Marguerite B, additional, McDonnell, Peter J, additional, McGillivray, Robert, additional, McKeown, Craig A, additional, McLaughlin, James, additional, McMullen, W Wynn, additional, Melamed, Shlomo, additional, Meligonis, George, additional, Mendrinos, Efstratios, additional, Meyer, Dale R, additional, Meyerle, Catherine B, additional, Mieler, William F, additional, Migliori, Michael, additional, Mihm, Martin C, additional, Miller, Darlene, additional, Miller, David, additional, Miller, Joan W, additional, Miller, Neil R, additional, Mills, David M, additional, Mills, Monte D, additional, Milman, Tatyana, additional, Mogk, Lylas, additional, Mogk, Marja, additional, Monés, Jordi, additional, Montes-Micó, Robert, additional, Morse, Christie L, additional, Morton, Asa D, additional, Moskowitz, Anne, additional, Mukai, Shizuo, additional, Murphree, A Linn, additional, Murphy, Robert P, additional, Murray, Timothy G, additional, Murray, Philip I, additional, Nagao, Karina, additional, Neitz, Jay, additional, Neitz, Maureen, additional, Netland, Peter A, additional, Neufeld, Arthur H, additional, Newman, Nancy J, additional, Ng, Eugene WM, additional, Nguyen, Quan Dong, additional, Niederkorn, Jerry Y, additional, Noecker, Robert J, additional, Nussenblatt, Robert B, additional, O'Brien, Joan M, additional, O'Brien, Paul D, additional, O'Brien, Terrence P, additional, O'Day, Denis, additional, Olk, R Joseph, additional, Olsen, Karl R, additional, Onal, Sumru, additional, Ooi, Yen Hoong, additional, Opremcak, E Mitchel, additional, Ousler, George, additional, Ozment, Randall R, additional, Packer, Samuel, additional, Palmer, Millicent L, additional, Papaliodis, George N, additional, Park, DJ John, additional, Parke, David W, additional, Parsa, Cameron F, additional, Parsons, M Andrew, additional, Pasquale, Louis R, additional, Patel, Neha N, additional, Patel, Sayjal J, additional, Patrianakos, Thomas D, additional, Patrinely, James R, additional, Pavan-Langston, Deborah, additional, Peli, Eli, additional, Pepin, Susan M, additional, Perez, Victor L, additional, Pérez-Santonja, Juan J, additional, Perfect, John R, additional, Perry, Henry D, additional, Piatigorsky, Joram, additional, Pieramici, Dante, additional, Pierce, Eric A, additional, Pineda, Roberto, additional, Pless, Misha L, additional, Pomeranz, Howard D, additional, Pournaras, Constantin J, additional, Power, William, additional, Prakash, Manvi, additional, Prasad, Anita G, additional, Purvin, Valerie, additional, Quillen, David A, additional, Quinn, Graham E, additional, Rabena, Melvin D, additional, Rae, James L, additional, Raizman, Michael B, additional, Randazzo, Alessandro, additional, Rao, Narsing A, additional, Rapuano, Christopher J, additional, Reeves, Sherman W, additional, Regillo, Carl D, additional, Reichel, Elias, additional, Reinke, Martin H, additional, Rhee, Douglas, additional, Richter, Claudia U, additional, Rizzo, Joseph F, additional, Robb, Richard M, additional, Roden, Anja C, additional, Rodgers, I Rand, additional, Rodrigues, Merlyn M, additional, Ron, Yonina, additional, Rose, Geoffrey E, additional, Rosen, Emanuel S, additional, Rosenbaum, James T, additional, Rosenthal, Perry, additional, Rouse, Strutha C, additional, Rovner, Barry W, additional, Rozanowska, Malgorzata, additional, Rubin, Michael P, additional, Rubin, Peter AD, additional, Rumelt, Shimon, additional, Rustgi, Anil K, additional, Rutar, Tina, additional, Ruttum, Mark S, additional, Rutzen, Allan R, additional, Ryan, Edward T, additional, Sadun, Alfredo A, additional, Sahel, José-Alain, additional, Saligan, Leorey, additional, Salim, Sarwat, additional, Salmon, John F, additional, Salomão, Diva R, additional, Sami, David, additional, Sandberg, Michael A, additional, Sangwan, Virender S, additional, Saornil, Maria A, additional, Sassani, Joseph W, additional, Sayegh, Rony R, additional, Schachat, Andrew P, additional, Schell, Wiley A, additional, Schefler, Amy C, additional, Scheufele, Tina, additional, Schiedler, Vivian, additional, Schneider, Gretchen, additional, Schroeder, Alison, additional, Schuchard, Ronald A, additional, Schuman, Joel S, additional, Schwab, Ivan R, additional, Scott, Adrienne, additional, Scott, Ingrid U, additional, Sears, Marvin L, additional, Seddon, Johanna M, additional, Seiler, Theo, additional, Selkin, Robert P, additional, Semba, Richard D, additional, Serbanescu, Irina, additional, Sexton, Briar, additional, Shaarawy, Tarek M, additional, Shah, Peter, additional, Shapiro, Aron, additional, Sharma, Savitri, additional, Shein, Jean, additional, Shetlar, Debra J, additional, Shields, M Bruce, additional, Shields, Carol L, additional, Shields, Jerry A, additional, Shingleton, Bradford J, additional, Shore, John W, additional, Shuba, Lesya M, additional, Simon, Guy J Ben, additional, Simmons, Richard J, additional, Simpson, Michael, additional, Singh, Arun D, additional, Singh, Omah S, additional, Sisley, Karen, additional, Sit, Arthur J, additional, Smerdon, David, additional, Smiddy, William E, additional, Smith, Ronald E, additional, Smith, Terry J, additional, Snebold, Neal G, additional, Sobrin, Lucia, additional, Sorenson, John A, additional, Soukiasian, Sarkis H, additional, Spaeth, George L, additional, Spaide, Richard F, additional, Srivastava, Monika, additional, Srivastava, Sunil K, additional, Stangos, Alexandros N, additional, Starck, Tomy, additional, Stark, Walter J, additional, Stein, Joshua D, additional, Steinert, Roger F, additional, Strauss, Leon, additional, Streeten, Barbara W, additional, Streilein, J Wayne, additional, Strong, James D, additional, Sugino, Ilene K, additional, Suhler, Eric B, additional, Sullivan, Timothy J, additional, Sun, Jennifer K, additional, Sunness, Janet S, additional, Sutula, Francis C, additional, Syed, Nasreen A, additional, Ta, Christopher N, additional, Takei, Hidehiro, additional, Talamo, Jonathan H, additional, Tamesis, Richard R, additional, Tamhankar, Madhura, additional, Tarbet, Kristen J, additional, Tarver-Carr, Michelle, additional, Terry, Mark A, additional, Thomas, Joseph M, additional, Thompson, Vance, additional, Thorne, Jennifer E, additional, Thurtell, Matthew J, additional, Tingey, David P, additional, To, King W, additional, Tobaigy, Faisal M, additional, Tolentino, Michael J, additional, Tong, Melissa G, additional, Torkildsen, Gail, additional, Toth, Cynthia A, additional, Traboulsi, Elias I, additional, Trucksis, Michele, additional, Tsai, James C, additional, Tsai, Julie H, additional, Tse, David T, additional, Tseng, Scheffer CG, additional, Tu, Elmer Y, additional, Udell, Ira J, additional, Valenzuela, Alejandra A, additional, Van Gelder, Russell N, additional, Van Stavern, Gregory P, additional, Vander Veen, Deborah K, additional, Vavvas, Demetrios, additional, Verity, David H, additional, Vinciguerra, Paolo, additional, Vinger, Paul F, additional, Volpe, Nicholas J, additional, Wackernagel, Werner, additional, Wadhwa, Sonal Desai, additional, Wagoner, Michael D, additional, Waheed, Nadia K, additional, Walton, David S, additional, Wand, Martin, additional, Wang, Jie Jin, additional, Warden, Scott M, additional, Webb, Lennox, additional, Weber, David, additional, Wee, Daniel, additional, Westerfeld, Corey B, additional, Westfall, Christopher T, additional, Whitcup, Scott M, additional, White, Valerie A, additional, White, William L, additional, Wickens, Jason, additional, Wiggs, Janey L, additional, Wilensky, Jacob T, additional, Wilkinson, Charles P, additional, Williams, Patrick D, additional, Wilson, David J, additional, Wilson, M Roy, additional, Wilson, Steven E, additional, Winokur, Jules, additional, Wirostko, William J, additional, Wollstein, Gadi, additional, Wong, Albert Chak Ming, additional, Wong, Tien Y, additional, Woog, John J, additional, Wride, Michael, additional, Wu, Carolyn S, additional, WuDunn, Darrell, additional, Yang, Jean, additional, Yannuzzi, Lawrence A, additional, Yaremchuk, Michael J, additional, Yeatts, R Patrick, additional, Yee, Richard W, additional, Yeh, Steven, additional, Young, Lucy HY, additional, Yu, Jenny Y, additional, Yue, Beatrice YJT, additional, Zacks, Charles M, additional, Zagelbaum, Bruce M, additional, Zamani, Maryam, additional, Zarbin, Marco, additional, Zografos, Leonidas, additional, and Zoumalan, Christopher I, additional

Published
2008
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34. Effect of Intravitreous Anti-Vascular Endothelial Growth Factor vs Sham Treatment for Prevention of Vision-Threatening Complications of Diabetic Retinopathy: The Protocol W Randomized Clinical Trial.

Author

Maturi, Raj K, Glassman, Adam R, Josic, Kristin, Antoszyk, Andrew N, Blodi, Barbara A, Jampol, Lee M, Marcus, Dennis M, Martin, Daniel F, Melia, Michele, Salehi-Had, Hani, Stockdale, Cynthia R, Punjabi, Omar S, Sun, Jennifer K, and DRCR Retina Network

Published
2021
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36. Retinoblastoma in transgenic mice

Author

Windle, Jolene J., Albert, Daniel M., O'Brien, Joan M., Marcus, Dennis M., Disteche, Christine M., Bernards, Rene, and Mellon, Pamela L.

Subjects
Retinoblastoma -- Causes of, Retinoblastoma -- Models, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Retinoblastoma, a malignant tumor of the eye which occurs in children, is the result of an inherited defect in the Rb gene. Any mutations which inactivate or eliminate the product of both Rb genes will cause the tumor. Research in mice has now revealed that the introduction of a viral protein into mice can cause retinoblastoma. The protein, called T antigen, is a product of simian virus 40, an animal virus which causes tumors. When the gene for T antigen was injected into fertilized mouse eggs, it was possible to obtain 15 strains of mice which had been transfected, and now carry the T antigen gene among their own. These mice had tumors in a number of different tissues, but one male developed eye cancer at the age of five months. The cancer was completely heritable, and 50 percent of his offspring developed eye cancer, as would be expected from a Mendelian dominant gene. Histological examination of the tumors revealed that they were retinoblastomas. Since the development of retinoblastoma in humans involves a mutation in the Rb gene, it is not clear why the presence of T antigen or its gene should cause retinoblastoma in these mice. One intriguing possibility is that the T antigen specifically binds to and inactivates the Rb gene product, which is necessary to inhibit carcinogenesis. Binding between T antigen and the Rb gene product has been demonstrated in vitro. In the transgenic mice, the retinoblastoma cells express both the Rb gene product and T antigen; it is tempting to speculate that the inhibition of the Rb product is occurring in vivo as well, and is responsible for producing the highly characteristic retinoblastoma observed in these mice. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

37. The Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration

Author

Campochiaro, Peter A., primary, Marcus, Dennis M., additional, Awh, Carl C., additional, Regillo, Carl, additional, Adamis, Anthony P., additional, Bantseev, Vladimir, additional, Chiang, Yawen, additional, Ehrlich, Jason S., additional, Erickson, Signe, additional, Hanley, William D., additional, Horvath, Joshua, additional, Maass, Katie F., additional, Singh, Natasha, additional, Tang, Fan, additional, and Barteselli, Giulio, additional

Published
2019
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40. Nucleolar organizer regions in iris nevi and melanomas

Author

Marcus, Dennis M., Mawn, Louise A., Egan, Kathleen M., and Albert, Daniel M.

Subjects
Nucleolus organizer region -- Physiological aspects, Iris (Eye) -- Abnormalities, Eye cancer -- Genetic aspects, Health
Published
1992

41. The value of nucleolar organizer regions in uveal melanoma

Author

Marcus, Dennis M., Minkovitz, Jeffrey B., Wardwell, Scott D., and Albert, Daniel M.

Subjects
Eye cancer -- Genetic aspects, Melanoma -- Diagnosis, Nucleolus organizer region -- Research, Health
Abstract

Malignant melanoma is a malignant neoplasm composed of cells that produce melanin, a naturally occurring pigment found in the iris and choroid of the eye. Malignant melanoma of the uvea (the pigmented vascular tunic of the eye beneath the sclera that includes the iris, ciliary body, and choroid) can be assessed by study of cell nuclei and their features. Specific areas called nucleolar organizer regions are part of the nucleus of the cell and are responsible for the formation of the nucleolus (small dense structures composed of ribonucleic acid); these areas are essential in the production of ribosomal protein. One method used to evaluate the malignancy of various tumors is a silver staining of the nucleolar organizer regions. A study was undertaken to determine the effectiveness of this silver staining method in assessing the malignant potential of a variety of tumors of the eye. The tissue specimens studied included 126 ciliochoroidal melanomas, three nevi in eyes with melanoma, and one eye with a nevus. The results indicated that malignant lesions had higher average silver-stained nucleolar organizer region counts than did the benign nevi. Silver-stained nucleolar organizer regions correlated with cell division and tumor size. Silver staining of nucleolar organizer regions may be useful in assessing malignancy of uveal melanomas. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

42. Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti–Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema

Author

Jampol, Lee M., primary, Glassman, Adam R., additional, Liu, Danni, additional, Aiello, Lloyd Paul, additional, Bressler, Neil M., additional, Duh, Elia J., additional, Quaggin, Susan, additional, Wells, John A., additional, Wykoff, Charles C., additional, Browning, David, additional, Antoszyk, Andrew N., additional, Price, Angela K., additional, Fredenberg, Sherry L., additional, Herby, Jenna T., additional, Fleming, Christina J., additional, McClain, Ashley A., additional, Ennis, Sarah A., additional, Gallagher, Kelly R., additional, Karow, Angella S., additional, Grupp, Autumn C., additional, Puskas, Danielle, additional, Watson, Lynn, additional, Bojaj, Swann J., additional, Balasubramaniam, Uma M., additional, McClain, Donna, additional, Styles, Donna R., additional, Kuopus, Jeff A., additional, Kimrey, Kathryn, additional, Clark, Loraine M., additional, Jackson, Lisa A., additional, McOwen, Michael D., additional, Dunlap, Matt, additional, Held, Susannah J., additional, Pieramici, Dante J., additional, Nasir, Ma'an A., additional, Castellarin, Alessandro A., additional, Dhoot, Dilsher, additional, Fishbein, Sarah, additional, Giust, Jack, additional, Wan, Lisha, additional, Hanna, Michelle S., additional, Rabena, Melvin D., additional, Smith, Jerry, additional, Bone, Layne J., additional, Avery, Kelly, additional, Giust, Matthew, additional, Walker, Aimee, additional, Shook, Aimee H., additional, Esau, Sara, additional, Ruvalcaba, Nitce L., additional, Clark, W. Lloyd, additional, Johnson, David L., additional, Payne, John F., additional, Swinford, Tiffany R., additional, Taylor, Mallie M., additional, Garrison, Cassandra L., additional, Miller, Peggy D., additional, Houlahan, Amber R., additional, O'Neill, Charlotte A., additional, Floyd, Ashley, additional, Parker, Crystal C., additional, Sease, Courtney, additional, Graham, Tara, additional, Spencer, Robin, additional, Ogbuewu, Tiffany N., additional, Studebaker, Ashley, additional, Huggins, Tyler, additional, Spivey, Robbin, additional, Jones, Brian, additional, Williams, Ashley, additional, Petty, Ron, additional, Poston, Erin L., additional, Ward, G. Michael, additional, Baker, Carl W., additional, Tilford, Ron H., additional, Caldwell, Tracey M., additional, Lambert, Lynnette F., additional, Palmer, Mary J., additional, Martin, Tracey R., additional, Williams, Tana R., additional, Kettler, Samantha, additional, Camp, Alecia B., additional, Silva, Paolo S., additional, Arrigg, Paul G., additional, Sharuk, George S., additional, Shah, Sabera T., additional, Sun, Jennifer K., additional, Westerfeld, Corey, additional, Andreoli, Christopher Michael, additional, Schlossman, Deborah, additional, Murtha, Timothy, additional, Kwak, Hanna, additional, Flores, Flor M., additional, Stockman, Margaret E., additional, Kieser, Troy, additional, Krigman, Michael N., additional, Bestourous, Leila, additional, Weimann, Elizabeth S., additional, Cavallerano, Jerry D., additional, Hock, Kristen M., additional, Robertson, Mary Ann, additional, Kirby, Rita K., additional, Papaconstantinou, Steve L., additional, Madigan, Kylie M., additional, Cavicchi, Robert W., additional, Palitsch, Kate A., additional, Yilmaz, Taygan, additional, Berger, Brian B., additional, Jhaveri, Chirag D., additional, Moore, Tori, additional, Manhart, Ginger J., additional, Walsh, Rachel A., additional, Gunderson, Ivana, additional, Riepen, Dietrich, additional, Bravenec, Chelsey A., additional, Reid, Ryan M., additional, Ren, Yong, additional, Ostrander, Ben, additional, Stovall, Christopher C., additional, Elman, Michael J., additional, Liss, Robert A., additional, Leder, Henry A., additional, Starr, JoAnn, additional, Belz, Jennifer L., additional, Putzulo, Charlene K., additional, Sandler, Dallas R., additional, Simmons, Jennifer L., additional, Singletary, Pamela V., additional, Davis, Ashley, additional, Simpson, Perel M., additional, Coffey, Teresa, additional, Ketner, Daniel J., additional, Cain, Terri, additional, Metzger, Ashley M., additional, Sotirakos, Peter, additional, Marcus, Dennis M., additional, Singh, Harinderjit, additional, Roberts, Courtney N., additional, Floyd, Geri L., additional, Ortiz, Siobhan O., additional, Mims, Virginia, additional, Foster, L. Allison, additional, Coursey, Christy, additional, Gardner, Jared C., additional, Ivey, Ken, additional, O'Keefe, John Stewart, additional, Astruc, Juan A., additional, Schwent, Bryan J., additional, Tabassian, Ali R., additional, Rosen, Suzette A., additional, Vaughan, David C., additional, Michaels, Jeffrey, additional, Arndt, Natalie J., additional, Maziarz, John J., additional, Friedman, Scott M., additional, Moinfar, Nader, additional, Williamson, Kimberly A., additional, Fagan, Damanda F., additional, Dawson, Katrina L., additional, Walters, Paige N., additional, McKinney, Allen, additional, Carlton, Steve, additional, Kwun, Robert C., additional, Knudsen, Victoria L., additional, Winward, Kirk E., additional, Swartz, Mano, additional, Howard, James G., additional, Riley, Michelle, additional, Taylor, Gena, additional, Holt, Michelle, additional, Winward, Jason G., additional, Walsh, Adam, additional, Taylor, Teresa, additional, Walsh, Daniel, additional, Hampton, G. Robert, additional, Brown, Jamin S., additional, Seth, Rajeev K., additional, Sienkiewycz, Laurie J., additional, Appleton, Deborah A., additional, Grinnell, Cindy J., additional, Cowley, Charity A., additional, Kwasniewski, Lynn M., additional, Manley, Michelle L., additional, Robarge, Nicole E., additional, DeSantis, Stefanie R., additional, Hay, Peter B., additional, DeForge, Teresa M., additional, Wong, Tien P., additional, Chen, Eric, additional, Brown, David M., additional, Kim, Rosa Y., additional, Major, James C., additional, Schefler, Amy C., additional, Fish, Richard H., additional, Benz, Matthew S., additional, Lipman, Meredith, additional, Hutson, Amy, additional, Landaverde, Nubia, additional, Chancey, Ashley E., additional, Cone, Cassie, additional, Royse, Tressa, additional, Sneed, Veronica A., additional, Almanza, Belinda A., additional, Dives, Brenda, additional, Richter, Beau A., additional, Kegley, Eric N., additional, Lauer, Andreas K., additional, Flaxel, Christina J., additional, Bailey, Steven T., additional, Schain, Mitchell, additional, Lundquist, Ann D., additional, Hanel, Shelley A., additional, Ira, Shirley D., additional, Nolte, Susan K., additional, Steinkamp, Peter N., additional, Ryan, Dawn M., additional, Pickell, Scott R., additional, Hui, Jocelyn T., additional, Brix, Michelle, additional, Barth, Jordan, additional, Howell, Chris S., additional, Fox, Gregory M., additional, Cooper, Blake A., additional, Batlle, Ivan R., additional, Manning, Lexie R., additional, Batlle, Karla A., additional, Wyrick, Holly, additional, Pippin, Katherine, additional, Perkins, Samantha, additional, Yeager, Frank T., additional, Rush, Ryan B., additional, Gardner, Glenn R., additional, Rush, Christi, additional, Hawkins, Johnathan R., additional, Dumas, Brenda, additional, Ysasaga, Ben, additional, Shah, Chirag P., additional, Morley, Michael G., additional, Wiegand, Torsten W., additional, Cleary, Tina S., additional, Topping, Trexler M., additional, Colegrove, Lindsey, additional, Bechtel, Katharine, additional, Johnson, Britta, additional, Lebedew, Lisa, additional, Lorius, Natacha, additional, Chong, Sandy G., additional, Stone, Jennifer L., additional, Jones, Michael Cullen, additional, Donovan, Dennis, additional, Malone, Sherry, additional, Graham, Margie, additional, Santos, Audrey, additional, Bennett, Steve A., additional, Blinder, Kevin J., additional, Smith, Bradley T., additional, Nobel, Ginny S., additional, Weeks, Rhonda F., additional, Hoehn, Erika A., additional, Stuart, Maria A., additional, Pepple, Kelly E., additional, Boyd, Lynda K., additional, Pulliam, Brook G., additional, Schremp, Steve A., additional, Guevara, Stephanie L., additional, Wehmeier, Jarrod, additional, Wright, Timothy L., additional, Gabel, Dana L., additional, Miller, David G., additional, Schartman, Jerome P., additional, Singerman, Lawrence J., additional, Coney, Joseph M., additional, Novak, Michael A., additional, Rao, Llewelyn J., additional, Rath, Susan C., additional, McNamara, Elizabeth, additional, Stone, Larraine, additional, Smith, Veronica A., additional, Rykena, Cecelia, additional, DuBois, Kimberly A., additional, Ilc, Mary A., additional, Tanner, Vivian, additional, Drury, Kim, additional, Nitzsche, Trina M., additional, Greanoff, Gregg A., additional, DuBois, John C., additional, Burgess, Stuart K., additional, Lara, Tirso M., additional, Pereda, Noel H., additional, Fernandez, Cindy V., additional, Davis, Deborah, additional, Quinchia, Evelyn, additional, Workman, Karen, additional, Nielsen, Jared S., additional, Sohn, Jeong-Hyeon, additional, Alliman, Kyle J., additional, Saggau, David D., additional, Parker, Marianne, additional, George, Bethany, additional, Eastvold, Carrie L., additional, Sells, Kristin, additional, Woehl, Tami Jo, additional, Johnson, Marilyn A., additional, Keenan, Holly, additional, Coleman, Jennifer L., additional, Spillman, Jamie, additional, Freeman, Shannon, additional, Schmidt, Leigh S., additional, Boender, Lisa M., additional, Partin, Jill L., additional, Bennett, Bailey R., additional, Rostvold, Jay, additional, McLure Stone, Cameron, additional, Raymer, Lea R., additional, Menzel, Andrea K., additional, Rickman, Leslie D., additional, Campbell, Barbara, additional, Sherlin, Lorraine P., additional, Hawkins, Lisa H., additional, Buckner, Melissa L., additional, Matsipura, Olesya N., additional, Price, Paula A., additional, Ghuman, A. Thomas, additional, Raskauskas, Paul A., additional, Sharma, Ashish G., additional, Wing, Glenn, additional, Walker, Joseph P., additional, Knips, Eileen, additional, Kiesel, Cheryl, additional, Peters, Crystal Y., additional, Ryan, Cheryl, additional, Greenhoe, Laura, additional, Torres, Natalie N., additional, Youngblood, Rebecca J., additional, Turnbo, Danielle, additional, Leslie, Anita H., additional, Schoeman, Etienne C., additional, Kiesel, Raymond K., additional, Kingsley, Ronald M., additional, Shah, Vinay A., additional, Leonard, Robert E., additional, Miller, Heather R., additional, Icks, Sonny, additional, Bergman, Vanessa A., additional, Drummond, Vanessa K., additional, Ross, Brittany L., additional, Ellis, Reshial D., additional, Whittington, Tina R., additional, Almeida, Shannon R., additional, Butt, Amanda M., additional, Burris, Russ, additional, Peters, Mark A., additional, Lee, Michael S., additional, Tlucek, Paul S., additional, Ma, Colin, additional, Hobbs, Stephen, additional, Milliron, Amanda C., additional, Ho, Stephanie L., additional, Kopfer, Marcia, additional, Logan, Joe, additional, Hoerner, Christine, additional, Khawly, Joseph A., additional, Rahman, Hassan T., additional, Abdelgani, Diana, additional, Miller, Pam S., additional, Fredrickson, Debbie, additional, Pineda, Erica, additional, Lopez, Desiree, additional, Lowd, Donald K., additional, Blank, Colin, additional, Martinez, Lorena R., additional, Muniz, Jason E., additional, Gottlieb, Justin, additional, Ip, Michael S., additional, Blodi, Barbara A., additional, Dietzman, Kristine A., additional, Burke, Kathryn F., additional, Smith, Christopher M., additional, Olson, Shelly R., additional, Wealti, Angela M., additional, Reed, Sandie L., additional, Krolnik, Denise A., additional, Peterson, John C., additional, Gonzalez, Victor Hugo, additional, Diaz-Rohena, Roberto, additional, Santiago, Juan G., additional, Adyanthaya, Rohit, additional, Patel, Nehal R., additional, Anaya, Deyla, additional, Garcia, Dina, additional, Cruz, Edna E., additional, Alvarez, Crystal A., additional, Iracheta, Ruth, additional, Rodriguez, Jessica, additional, Cantu, Monica R., additional, Flores, Rebecca R., additional, Jasso, Hector, additional, Rodriguez, Rachel, additional, Miranda, Karina, additional, Lozano, Krystle R., additional, Garza, Maricela, additional, Aguero, Lazaro, additional, Sandoval, Amanda L., additional, Montemayor, Monique, additional, Alonso, Samuel, additional, Garza, Santos, additional, DiLoreto, David Allen, additional, Ramchandran, Rajeev S., additional, Kleinman, David M., additional, O'Gara, George W., additional, Czubinski, Andrea M., additional, MacDowell, Peter, additional, Steinmetz, Kari M., additional, Castillo, Dan A., additional, Yu, Yvonne F., additional, Tongue, Salina M., additional, Keim, Melissa S., additional, Hollar, Rachel, additional, Deats, Brandi N., additional, Richardson, Brittany S., additional, Singer, Lynn, additional, Pannell, Taylor A., additional, Daniels, Stewart A., additional, Ranchod, Tushar M., additional, Leong, Craig J., additional, Touson, Stacey, additional, Earl, Shannon R., additional, Bartlett, Melissa C., additional, Fernando, Christine, additional, Factor, Djorella, additional, Garcia, Jessica, additional, Nguyen, Anna K., additional, Hom, Betty, additional, Walker, Cathy, additional, Marudo, Grace M., additional, Suazo, Jose Carlos, additional, McNeil, Leah M., additional, Hanamoto, Fred, additional, Hughes, Matthew D., additional, Ross, Robin D., additional, Sanford, Susan M., additional, Markiewicz, Nicole Martini, additional, Utley, Tracy M., additional, Henderson, Shannon, additional, Lippincott, Joanie H., additional, Streasick, Patricia, additional, Glazer, Louis C., additional, Garber, Frank W., additional, Zheutlin, Jeffrey D., additional, Listerman, Angela D., additional, Feehan, Christine E., additional, Cruz, Heather L., additional, Kuitula, Donald E., additional, Rainey, Olivia P., additional, Weatherbee, Sue, additional, Googe, Joseph M., additional, Shuler, R. Keith, additional, Anderson, Nicholas G., additional, Perkins, Stephen L., additional, Oliver, Kristina, additional, Grindall, Nicole, additional, Arnold, Ann, additional, Beerbower, Jennifer, additional, Hunt, Cecile, additional, Schulz, Kathy L., additional, Oelrich, Sarah M., additional, Whetstone, Jerry K., additional, Walsh, Justin, additional, Morris, Chris, additional, Wong, Robert W., additional, Nixon, Peter A., additional, Leon, Jeni L., additional, Montesclaros, Chris A., additional, Leung, Carrie E., additional, Le, Phill, additional, Harborth, Codey L., additional, Rodriguez, Margaret A., additional, Mangham, Cory, additional, Aaberg, Thomas M., additional, Westhouse, Scott J., additional, Vincent, Holly L., additional, Malone, Rebecca, additional, Karsten, Kathy L., additional, Maturi, Raj K., additional, Harless, Ashley M., additional, Novak, Carolee K., additional, Bleau, Laura A., additional, Steele, Thomas, additional, Harris, Charlotte, additional, Bildner, Alisha, additional, Maple, Abby, additional, Stone, Thomas W., additional, Isernhagen, Rick D., additional, Kitchens, John W., additional, Holcomb, Diana M., additional, Van Arsdall, Jeanne, additional, Buck, Michelle, additional, Slade, Edward A., additional, Chiu, Mark T., additional, Reddy, Ashok K., additional, Wyant, Frank W., additional, Montano-Niles, Mary M., additional, Carter, Lorraine J., additional, Maerki, Shirley, additional, Tartaglia, Laura, additional, Gomez, Paul P., additional, Maestas, Stephen A., additional, Shanta, Camille, additional, Jimenez, Lisbrenda M., additional, Stoltz, Robert A., additional, Vanderveldt, Stephanie L., additional, Lampert, Scott I., additional, Marcus, Leslie G., additional, Fulbright, Shelly, additional, Martin, James P., additional, Novack, Roger L., additional, Liao, David S., additional, Lo, Tammy Eileen, additional, Kurokouchi, Janet, additional, Ngo, Richard, additional, Hoang, Connie V., additional, Sierra, Julio, additional, Zamboni, Adam, additional, Protacio, Eric G., additional, Kessinger, Jeff, additional, Garg, Seema, additional, Houghton, Odette M., additional, Ulrich, Jan Niklas, additional, Chavala, Sai H., additional, DuBose, Elizabeth L., additional, Barnhart, Cassandra J., additional, Karmalkar, Megha, additional, Jani, Pooja D., additional, Goble, Justin, additional, Cantrell, Debra, additional, Esquejo, Rona Lyn, additional, Shah, Sandeep N., additional, Harmon, Natasha, additional, Dhalla, Mandeep S., additional, del Cid, Mario R., additional, Halperin, Lawrence S., additional, Brady, Jaclyn A., additional, Hamlin, Monica, additional, Lopez, Monica L., additional, Mariano, Jamie, additional, Neale, Candace M., additional, Veksler, Rita R., additional, Mannarelli, Angelica, additional, Coffee, Robert E., additional, Carvounis, Petros Euthymiou, additional, Hemati, Pejman, additional, Dorenbach, Cindy J., additional, Joshi, Annika S., additional, Leger, April, additional, Barnett, Dana B., additional, Morales, Joseph F., additional, Mansour, Sam E., additional, Choyce, Cathy, additional, Dirawatun, Aissa L., additional, Nagy, Emma A., additional, Kerkstra, Jamie C., additional, Fan, Joseph T., additional, Suthar, Mukesh Bhogilal, additional, Rauser, Michael E., additional, Santiago, Gisela, additional, Marvyn Cerdenio, Liel, additional, Perez, Brandi J., additional, Halsey, Kara E., additional, Kiernan, William H., additional, Knabb, Jesse, additional, Catren, Rachel, additional, Shami, Michel, additional, Arrington, Brenda K., additional, Neuling, Keri S., additional, Meeks, Ashaki, additional, Garcia, Natalie R., additional, Blair, Kayla, additional, Rhymes, Ginger K., additional, Medrano, Janet, additional, Kim, Judy E., additional, Weinberg, David V., additional, Stepien, Kimberly E., additional, Connor, Thomas B., additional, Williams, Vesper V., additional, Kaczanowski, Tracy L., additional, Packard, Krissa L., additional, Flanders, Judy, additional, Barwick, Vicki, additional, Winter, Pat A., additional, Beringer, Joseph R., additional, Selchert, Kathy J., additional, Lehr, John T., additional, Rodriguez-Roman, Elaine, additional, Jones, Teri, additional, Haddox, Martha Eileen, additional, Pena, Mark, additional, Hernandez, Brenda, additional, Chan, Clement K., additional, Lalezary, Maziar, additional, Lin, Steven G., additional, Walther, Kimberly S., additional, Gonzales, Tiana, additional, Myers, Lenise E., additional, Huff, Kenneth M., additional, Chace, Richard, additional, Kallay, Sunny, additional, Stevens, Kirsten, additional, Dolbec, Nicole, additional, Baker-Hill, Ronda, additional, Surette, Janea, additional, Rose, Steven J., additional, Connolly, Brian P., additional, Guillet, Ernest G., additional, Hall, Edward F., additional, Yagoda, Margaret M., additional, Doran, Mary Jo, additional, Burgess, Mindy, additional, Reynard, Ann, additional, Powers, Margaret, additional, Territo, Joe, additional, Mein, Calvin E., additional, Chica, Moises A., additional, Lane, R. Gary, additional, Holy, Sarah Elizabeth, additional, Kirschbaum, Lita, additional, Martinez, Vanessa D., additional, Baker, Jaynee, additional, Kincaid, Christa G., additional, Castillo, Elaine, additional, Wienecke, Christopher Sean, additional, Schlichting, Sara L., additional, Nakoski, Brenda, additional, Diddie, Kenneth R., additional, Cadwell, Deborah M., additional, Van Arsdale, Louise, additional, Boisvert, Taryn F., additional, Galonsky, Joyce, additional, O'Hayer, Susie, additional, Johnson, Melissa L., additional, McCabe, Frank J., additional, Baker, Brad J., additional, Defrin, Melvyn H., additional, Lampson, Marie V., additional, Pratte, Heather, additional, Baron, Selena A., additional, Borelli, Aundrea S., additional, Davidorf, Frederick H., additional, Wells, Michael B., additional, Chang, Susie, additional, Christoforidis, John Byron, additional, Letson, Alan D., additional, Salerno, Jill A., additional, Perry, Jerilyn G., additional, Shelley, Stephen E., additional, Fish, Patrick J., additional, Scott, Michael H., additional, Dixon, James A., additional, Walsh, Shannon R., additional, Ozpirincci, Philomina M., additional, Tebon, Brenda L., additional, Moyle, Marcia J., additional, Pavlica, Michael R., additional, Matta, Noelle S., additional, Brubaker, Cristina M., additional, Backer, Alyson B., additional, Bhagat, Neelakshi, additional, Fay, Catherine, additional, Mikheyeva, Tatiana, additional, Lazar, Michael, additional, Ellenberger, Janie D., additional, Malpica, Beth, additional, Brucker, Alexander J., additional, Kim, Benjamin J., additional, VanderBeek, Brian L., additional, Drossner, Sheri, additional, DuPont, Joan C., additional, Salvo, Rebecca, additional, Engelhard, Stephanie B., additional, Berger, Jim M., additional, Morales, Sara, additional, Serpentine, Beth, additional, Kaufman, Paul L., additional, McCluskey, Jessica D., additional, Wynne, Kathy T., additional, Jordan, Julian, additional, Watson, Brandun, additional, Wirthlin, Robert S., additional, Guglielmo, Eric S., additional, Dittman, Eileen A., additional, Waidelich, Dylan C., additional, Garza, Cristofer J., additional, Stone, Adeline M., additional, Oakes, Ashley Nicole, additional, Suner, Ivan J., additional, Hammer, Mark E., additional, Peden, Marc C., additional, Traynom, Janet R., additional, DenBoer, Rochelle, additional, Vargo, Heidi, additional, Ramsey, Susan, additional, Malzahn, Anita Kim, additional, Jeffres, Debra, additional, Chaudhry, Nauman A., additional, Shah, Sumit P., additional, Haffner, Gregory M., additional, German, Emiliya, additional, Moreau, Shannan, additional, Fox, Laura A., additional, Matteson, Jennifer M., additional, Pelletier, JoAnna L., additional, Fontecchio, Alison, additional, Morse, Emily, additional, McNamara, Greg, additional, Laglivia, Marie Grace, additional, Scherf, Marissa L., additional, LaPre, Angela, additional, Cocilo, Justin A., additional, Das, Arup, additional, Friesen, Linda, additional, Franco, Michele, additional, Lucero, Johnny, additional, Frazier, Melissa, additional, Laviolette, Robert, additional, Mian, Umar Khalil, additional, Riemer, Rebecca L., additional, Koestenblatt, Evelyn, additional, Wolf, Louise V., additional, Kim, Christine, additional, Katkovskaya, Irina, additional, Otoo, Erica, additional, Ellerbe, Kevin A., additional, Boyd, Kenneth, additional, Costa, Caroline, additional, Edwards, Paul Andrew, additional, Gao, Hua, additional, Hessburg, Thomas, additional, Desai, Uday, additional, Murphy, Janet, additional, Monk, Mary K., additional, Hall, Julianne, additional, Mazurek, Melina, additional, Ventimiglia, Katie M., additional, Rusinek, Brian A., additional, Stern, Bradley A., additional, Brouhard, Kris, additional, Weier, Katie M., additional, Allis, Megan, additional, Shaken, Jenny, additional, Massu, Nicole M., additional, Troszak, Tracy A., additional, Burley, David, additional, Bhavsar, Abdhish R., additional, Emerson, Geoffrey G., additional, Jones, Jacob M., additional, Anderson, Tracy A., additional, Gilchrist, Andrea, additional, Peloquin, Matt D., additional, Gaid, Gaid, additional, Vang, Yang, additional, Ryan, Samantha, additional, Vang, Denise, additional, Evans, Alanna C., additional, Scherer, Tonja, additional, Lazarus, Howard S., additional, Bunch, Debra Paige, additional, Davis, Liana C., additional, Booth, Kelly, additional, Trimble, Margaret, additional, Bledsaw, Mary A., additional, Moore, Jay, additional, Rosberger, Daniel F., additional, Groeschel, Sandra, additional, Madry, Miriam A., additional, DiGirolamo, Nikoletta, additional, Pressley, Dustin, additional, Santora, Robert, additional, Gomez, Yenelda M., additional, Olsen, Karl R., additional, Bergren, Robert L., additional, Conrad, P. William, additional, Rath, Pamela P., additional, Vyas, Avni Patel, additional, Liu, Judy C., additional, Merlotti, Lori A., additional, Chamberlin, Jennifer L., additional, Mechling, Holly M., additional, Kelly, Mary E., additional, Marfisi, Kellianne, additional, Yeckel, Kimberly A., additional, Bennett, Veronica L., additional, Schultz, Christina M., additional, Rigoni, Grace A., additional, Walter, Julie, additional, Forish, Missy A., additional, Fec, Amanda, additional, Foreman, Courtney L., additional, Steinberg, David, additional, McBroom, Keith D., additional, Chen, Melvin C., additional, Levy, Marc H., additional, Torres, Waldemar, additional, Jelemensky, Peggy, additional, Raphael, Tara L., additional, Rich, Joann, additional, Sneath, Mark, additional, Kinyoun, James L., additional, Vemulakonda, Gurunadh Atmaram, additional, Rath, Susan A., additional, Ernst, Patricia K., additional, Pettingill, Juli A., additional, Jones, Ronald C., additional, Clifton, Brad C., additional, Leslie, James D., additional, Solomon, Sharon D., additional, Levin, Lisa K., additional, Donohue, Deborah, additional, Frey, Mary, additional, Larez, Lorena, additional, Murray, Keisha, additional, Denbow, Rita L., additional, Graul, Janis, additional, Emmert, David, additional, Herring, Charles, additional, Rhoton, Nick, additional, Belz, Joe, additional, Lyon, Alice T., additional, Mirza, Rukhsana G., additional, Krug, Amanda M., additional, Ramirez, Carmen, additional, Kaminski, Lori, additional, Castro-Malek, Anna Liza M., additional, Mills, Amber N., additional, Rozenbajgier, Zuzanna, additional, Skelly, Marriner L., additional, Simjanoski, Evica, additional, Degillio, Andrea R., additional, Lim, Jennifer I., additional, Chau, Felix Y., additional, Niec, Marcia, additional, Johnson, Tametha, additional, Ovando, Yesenia, additional, Janowicz, Mark, additional, Carroll, Catherine, additional, Gross, Jeffrey G., additional, Fishburne, Barron C., additional, Flowers, Amy M., additional, Stroman, Riley, additional, Ochieng, Christen, additional, McDowell, Angelique S.A., additional, Paul, Ally M., additional, Price, Randall L., additional, Drouilhet, John H., additional, Lacaden, Erica N., additional, Nobler, Deborah J., additional, Cummings, Howard L., additional, Long, Deanna Jo, additional, McCord, Ben, additional, Robinson, Jason, additional, Swift, Jamie, additional, Maynard, Julie P., additional, Pahk, Patricia J., additional, Palmer-Dwore, Hannah, additional, Dave, Dipali H., additional, Pacheco, Mariebelle, additional, Galati, Barbara A., additional, Simpson, Eneil, additional, Barkmeier, Andrew J., additional, Vogen, Diane L., additional, Berg, Karin A., additional, Howard, Shannon L., additional, Burrington, Jean M., additional, Morgan, Jessica Ann, additional, Overend, Joan T., additional, Goddard, Shannon, additional, Lewison, Denise M., additional, Tesmer, Jaime L., additional, Greven, Craig Michael, additional, Fish, Joan, additional, Everhart, Cara, additional, Clark, Mark D., additional, Miller, David T., additional, Hubbard, George Baker, additional, Yan, Jiong, additional, Cribbs, Blaine E., additional, Curtis, Linda T., additional, Brower, Judy L., additional, Dobbs, Jannah L., additional, Jordan, Debora J., additional, Ahmad, Baseer U., additional, Huang, Suber S., additional, Sedlacek, Hillary M., additional, Hornsby, Cherie L., additional, Ferguson, Lisa P., additional, Carlton, Kathy, additional, Sholtis, Kelly A., additional, Allchin, Peggy, additional, Clow, Claudia, additional, Harrod, Mark A., additional, Pankhurst, Geoffrey, additional, Baum-Rawraway, Irit, additional, Hrvatin, Stacie A., additional, Gentile, Ronald C., additional, Yang, Alex, additional, Carrasquillo-Boyd, Wanda, additional, Masini, Robert, additional, Samy, Chander N., additional, Kraut, Robert J., additional, Shirley, Kathy, additional, Corso, Linsey, additional, Ely, Karen, additional, Scala, Elizabeth, additional, Gross, Stewart, additional, Alava, Vanessa, additional, Margalit, Eyal, additional, Neely, Donna G., additional, Blaiotta, Maria, additional, Hagensen, Lori, additional, Harris, April E., additional, Lennon, Rita L., additional, Cota, Denice R., additional, Wilson, Larry, additional, Aiello, Lloyd P., additional, Beck, Roy W., additional, Bressler, Susan B., additional, Chalam, Kakarla V., additional, Danis, Ronald P., additional, Arnold-Bush, Bambi J., additional, Ferris, Frederick, additional, Almukhtar, Talat, additional, Dale, Brian B., additional, Baptista, Alyssa, additional, Connor, Crystal, additional, Conner, Jasmine, additional, Constantine, Sharon R., additional, Dowling, Kimberly, additional, Dupre, Simone S., additional, Ayala, Allison R., additional, Huggins, Meagan L., additional, Inusah, Seidu, additional, Johnson, Paula A., additional, Loggins, Brenda L., additional, McClellan, Shannon L., additional, Melia, Michele, additional, Battle, Eureca, additional, Stockdale, Cynthia R., 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Published
2018
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46. Intravitreal Aflibercept for Diabetic Macular Edema: 100-Week Results From the VISTA and VIVID Studies

Author

Brown, David M, Schmidt Erfurth, Ursula, Diana V., Do, Holz, Frank G., Boyer, David S., Midena, Edoardo, Heier, Jeffrey S., Terasaki, Hiroko, Kaiser, Peter K., Marcus, Dennis M., Nguyen, Quan D., Jaffe, Glenn J., Slakter, Jason S., Simader, Christian, Soo, Yuhwen, Schmelter, Thomas, Yancopoulos, George D., Stahl, Neil, Vitti, Robert, Berliner, Alyson J., Zeitz, Oliver, Metzig, Carola, and Korobelnik, Jean François

Subjects
Vascular Endothelial Growth Factor A, Diabetic Retinopathy, Laser Coagulation, Recombinant Fusion Proteins, Visual Acuity, Angiogenesis Inhibitors, Macular Edema, Ophthalmology, Diabetes Mellitus, Type 1, Receptors, Vascular Endothelial Growth Factor, Diabetes Mellitus, Type 2, Double-Blind Method, Sickness Impact Profile, Intravitreal Injections, Humans, Fluorescein Angiography, Tomography, Optical Coherence
Abstract

To compare efficacy and safety of 2 dosing regimens of intravitreal aflibercept injection (IAI) with macular laser photocoagulation for diabetic macular edema (DME).Two similarly designed, randomized, phase 3 trials, VISTA(DME) and VIVID(DME).Patients (eyes; n=872) with type 1 or 2 diabetes mellitus who had DME with central involvement.Eyes received IAI 2 mg every 4 weeks (2q4), IAI 2 mg every 8 weeks after 5 monthly doses (2q8), or laser control.The primary end point was mean change from baseline in best-corrected visual acuity (BCVA) at week 52. This report presents the 100-week results including mean change from baseline in BCVA, proportion of eyes that gained ≥15 letters, and proportion of eyes with a ≥2-step improvement in the Diabetic Retinopathy Severity Scale (DRSS) score.Mean BCVA gain from baseline to week 100 with IAI 2q4, IAI 2q8, and laser control was 11.5, 11.1, and 0.9 letters (P0.0001) in VISTA and 11.4, 9.4, and 0.7 letters (P0.0001) in VIVID, respectively. The proportion of eyes that gained ≥15 letters from baseline at week 100 was 38.3%, 33.1%, and 13.0% (P0.0001) in VISTA and 38.2%, 31.1%, and 12.1% (P ≤ 0.0001) in VIVID. The proportion of eyes that lost ≥15 letters at week 100 was 3.2%, 0.7%, and 9.7% (P ≤ 0.0220) in VISTA and 2.2%, 1.5%, and 12.9% (P ≤ 0.0008) in VIVID. Significantly more eyes in the IAI 2q4 and 2q8 groups versus those in the laser control group had a ≥2 step improvement in the DRSS score in both VISTA (37.0% and 37.1% vs. 15.6%; P0.0001) and VIVID (29.3% and 32.6% vs. 8.2%; P ≤ 0.0004). In an integrated safety analysis, the most frequent serious ocular adverse event was cataract (2.4%, 1.0%, and 0.3% for 2q4, 2q8, and control).In both VISTA and VIVID, the 52-week visual and anatomic superiority of IAI over laser control was sustained through week 100, with similar efficacy in the 2q4 and 2q8 groups. Safety in these studies was consistent with the known safety profile of IAI.

Published
2015

47. Factors Associated With Visual Acuity and Central Subfield Thickness Changes When Treating Diabetic Macular Edema With Anti-Vascular Endothelial Growth Factor Therapy: An Exploratory Analysis of the Protocol T Randomized Clinical Trial.

Author

Bressler, Susan B., Odia, Isoken, Maguire, Maureen G., Dhoot, Dilsher S., Glassman, Adam R., Jampol, Lee M., Marcus, Dennis M., Solomon, Sharon D., Sun, Jennifer K., and Diabetic Retinopathy Clinical Research Network

Published
2019
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