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1. Surgical complications and clinical outcomes after dose-escalated trimodality therapy for non-small cell lung cancer in the era of intensity-modulated radiotherapy

Author

Liu, Kevin X, Sierra-Davidson, Kailan, Tyan, Kevin, Orlina, Lawrence T, Marcoux, J Paul, Kann, Benjamin H, Kozono, David E, Mak, Raymond H, White, Abby, and Singer, Lisa

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Lung Cancer, Clinical Research, Lung, Patient Safety, Evaluation of treatments and therapeutic interventions, 6.5 Radiotherapy and other non-invasive therapies, Aged, Carcinoma, Non-Small-Cell Lung, Chemoradiotherapy, Disease-Free Survival, Female, Humans, Lung Neoplasms, Radiotherapy Dosage, Radiotherapy, Intensity-Modulated, Retrospective Studies, Non-small cell lung cancer, Trimodality, Radiation, Intensity modulated radiotherapy, IMRT, Radiation dose, Other Physical Sciences, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis, Medical and biological physics
Abstract

BackgroundTrimodality therapy (TMT) with preoperative chemoradiation followed by surgical resection is used for locally-advanced non-small-cell lung cancer (LA-NSCLC). Traditionally, preoperative radiation doses ≤54 Gy are used due to concerns regarding excess morbidity, but little is known about outcomes and toxicities after TMT with intensity-modulated radiotherapy (IMRT) to higher doses.MethodsA retrospective analysis of patients who received planned TMT with IMRT for LA-NSCLC at Brigham and Women's Hospital/Dana-Farber Cancer Institute between 2008 and 2017 was performed. Clinical and treatment characteristics, pathologic response, and surgical toxicity were assessed. Kaplan-Meier method and log-rank test was used for survival outcomes. Cox proportional-hazards regression was used for multivariable analysis.ResultsForty-six patients received less than definitive doses of 7 days were associated with OS.ConclusionsWith IMRT, there was no increased rate of surgical complications in patients receiving higher doses of radiation. Survival outcomes or LOS did not differ based on radiation dose, but increased LOS was associated with worse OS. Larger prospective studies are needed to further examine outcomes after IMRT in patients with LA-NSCLC receiving TMT.

Published
2021

6. Data from Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

Author

Farago, Anna F., primary, Yeap, Beow Y., primary, Stanzione, Marcello, primary, Hung, Yin P., primary, Heist, Rebecca S., primary, Marcoux, J. Paul, primary, Zhong, Jun, primary, Rangachari, Deepa, primary, Barbie, David A., primary, Phat, Sarah, primary, Myers, David T., primary, Morris, Robert, primary, Kem, Marina, primary, Dubash, Taronish D., primary, Kennedy, Elizabeth A., primary, Digumarthy, Subba R., primary, Sequist, Lecia V., primary, Hata, Aaron N., primary, Maheswaran, Shyamala, primary, Haber, Daniel A., primary, Lawrence, Michael S., primary, Shaw, Alice T., primary, Mino-Kenudson, Mari, primary, Dyson, Nicholas J., primary, and Drapkin, Benjamin J., primary

Published
2023
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7. Supplementary Tables 4-5 from Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

Author

Farago, Anna F., primary, Yeap, Beow Y., primary, Stanzione, Marcello, primary, Hung, Yin P., primary, Heist, Rebecca S., primary, Marcoux, J. Paul, primary, Zhong, Jun, primary, Rangachari, Deepa, primary, Barbie, David A., primary, Phat, Sarah, primary, Myers, David T., primary, Morris, Robert, primary, Kem, Marina, primary, Dubash, Taronish D., primary, Kennedy, Elizabeth A., primary, Digumarthy, Subba R., primary, Sequist, Lecia V., primary, Hata, Aaron N., primary, Maheswaran, Shyamala, primary, Haber, Daniel A., primary, Lawrence, Michael S., primary, Shaw, Alice T., primary, Mino-Kenudson, Mari, primary, Dyson, Nicholas J., primary, and Drapkin, Benjamin J., primary

Published
2023
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8. Clinical Trial Protocol from Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

Author

Farago, Anna F., primary, Yeap, Beow Y., primary, Stanzione, Marcello, primary, Hung, Yin P., primary, Heist, Rebecca S., primary, Marcoux, J. Paul, primary, Zhong, Jun, primary, Rangachari, Deepa, primary, Barbie, David A., primary, Phat, Sarah, primary, Myers, David T., primary, Morris, Robert, primary, Kem, Marina, primary, Dubash, Taronish D., primary, Kennedy, Elizabeth A., primary, Digumarthy, Subba R., primary, Sequist, Lecia V., primary, Hata, Aaron N., primary, Maheswaran, Shyamala, primary, Haber, Daniel A., primary, Lawrence, Michael S., primary, Shaw, Alice T., primary, Mino-Kenudson, Mari, primary, Dyson, Nicholas J., primary, and Drapkin, Benjamin J., primary

Published
2023
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9. Supplementary Data from Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

Author

Farago, Anna F., primary, Yeap, Beow Y., primary, Stanzione, Marcello, primary, Hung, Yin P., primary, Heist, Rebecca S., primary, Marcoux, J. Paul, primary, Zhong, Jun, primary, Rangachari, Deepa, primary, Barbie, David A., primary, Phat, Sarah, primary, Myers, David T., primary, Morris, Robert, primary, Kem, Marina, primary, Dubash, Taronish D., primary, Kennedy, Elizabeth A., primary, Digumarthy, Subba R., primary, Sequist, Lecia V., primary, Hata, Aaron N., primary, Maheswaran, Shyamala, primary, Haber, Daniel A., primary, Lawrence, Michael S., primary, Shaw, Alice T., primary, Mino-Kenudson, Mari, primary, Dyson, Nicholas J., primary, and Drapkin, Benjamin J., primary

Published
2023
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10. Supplementary Data from EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer

Author

Koivunen, Jussi P., primary, Mermel, Craig, primary, Zejnullahu, Kreshnik, primary, Murphy, Carly, primary, Lifshits, Eugene, primary, Holmes, Alison J., primary, Choi, Hwan Geun, primary, Kim, Jhingook, primary, Chiang, Derek, primary, Thomas, Roman, primary, Lee, Jinseon, primary, Richards, William G., primary, Sugarbaker, David J., primary, Ducko, Christopher, primary, Lindeman, Neal, primary, Marcoux, J. Paul, primary, Engelman, Jeffrey A., primary, Gray, Nathanael S., primary, Lee, Charles, primary, Meyerson, Matthew, primary, and Jänne, Pasi A., primary

Published
2023
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11. Data from A Novel ALK Secondary Mutation and EGFR Signaling Cause Resistance to ALK Kinase Inhibitors

Author

Sasaki, Takaaki, primary, Koivunen, Jussi, primary, Ogino, Atsuko, primary, Yanagita, Masahiko, primary, Nikiforow, Sarah, primary, Zheng, Wei, primary, Lathan, Christopher, primary, Marcoux, J. Paul, primary, Du, Jinyan, primary, Okuda, Katsuhiro, primary, Capelletti, Marzia, primary, Shimamura, Takeshi, primary, Ercan, Dalia, primary, Stumpfova, Magda, primary, Xiao, Yun, primary, Weremowicz, Stanislawa, primary, Butaney, Mohit, primary, Heon, Stephanie, primary, Wilner, Keith, primary, Christensen, James G., primary, Eck, Michel J., primary, Wong, Kwok-Kin, primary, Lindeman, Neal, primary, Gray, Nathanael S., primary, Rodig, Scott J., primary, and Jänne, Pasi A., primary

Published
2023
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12. Supplementary Figures 1-4 from A Novel ALK Secondary Mutation and EGFR Signaling Cause Resistance to ALK Kinase Inhibitors

Author

Sasaki, Takaaki, primary, Koivunen, Jussi, primary, Ogino, Atsuko, primary, Yanagita, Masahiko, primary, Nikiforow, Sarah, primary, Zheng, Wei, primary, Lathan, Christopher, primary, Marcoux, J. Paul, primary, Du, Jinyan, primary, Okuda, Katsuhiro, primary, Capelletti, Marzia, primary, Shimamura, Takeshi, primary, Ercan, Dalia, primary, Stumpfova, Magda, primary, Xiao, Yun, primary, Weremowicz, Stanislawa, primary, Butaney, Mohit, primary, Heon, Stephanie, primary, Wilner, Keith, primary, Christensen, James G., primary, Eck, Michel J., primary, Wong, Kwok-Kin, primary, Lindeman, Neal, primary, Gray, Nathanael S., primary, Rodig, Scott J., primary, and Jänne, Pasi A., primary

Published
2023
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14. Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells

Author

Reversade, Bruno, Planes, R.; Pinilla, M.; Santoni, K.; Hessel, A.; Passemar, C.; Lay, K.; Paillette, P.; Valadao, A.C.; Robinson, K.S.; Bastard, P.; Lam, N.; Fadrique, R.; Rossi, I.; Pericat, D.; Bagayoko, S.; Leon-Icaza, S.A.; Rombouts, Y.; Perouzel, E.; Tiraby, M.; COVID Human Genetic Effort; Zhang, Q.; Cicuta, P.; Jouanguy, E.; Neyrolles, O.; Bryant, C.E.; Floto, A.R.; Goujon, C.; Lei, F.Z.; Martin-Blondel, G.; Silva, S.; Casanova, J.L.; Cougoule, C.; Marcoux, J.; Ravet, E.; Meunier, E., School of Medicine, Reversade, Bruno, Planes, R.; Pinilla, M.; Santoni, K.; Hessel, A.; Passemar, C.; Lay, K.; Paillette, P.; Valadao, A.C.; Robinson, K.S.; Bastard, P.; Lam, N.; Fadrique, R.; Rossi, I.; Pericat, D.; Bagayoko, S.; Leon-Icaza, S.A.; Rombouts, Y.; Perouzel, E.; Tiraby, M.; COVID Human Genetic Effort; Zhang, Q.; Cicuta, P.; Jouanguy, E.; Neyrolles, O.; Bryant, C.E.; Floto, A.R.; Goujon, C.; Lei, F.Z.; Martin-Blondel, G.; Silva, S.; Casanova, J.L.; Cougoule, C.; Marcoux, J.; Ravet, E.; Meunier, E., and School of Medicine

Abstract

Inflammation observed in SARS-CoV-2-infected patients suggests that inflammasomes, proinflammatory intracellular complexes, regulate various steps of infection. Lung epithelial cells express inflammasome-forming sensors and constitute the primary entry door of SARS-CoV-2. Here, we describe that the NLRP1 in-flammasome detects SARS-CoV-2 infection in human lung epithelial cells. Specifically, human NLRP1 is cleaved at the Q333 site by multiple coronavirus 3CL proteases, which triggers inflammasome assembly and cell death and limits the production of infectious viral particles. Analysis of NLRP1-associated pathways unveils that 3CL proteases also inactivate the pyroptosis executioner Gasdermin D (GSDMD). Subsequently, caspase-3 and GSDME promote alternative cell pyroptosis. Finally, analysis of pyroptosis markers in plasma from COVID-19 patients with characterized severe pneumonia due to autoantibodies against, or inborn errors of, type I interferons (IFNs) highlights GSDME/caspase-3 as potential markers of disease severity. Overall, our findings identify NLRP1 as a sensor of SARS-CoV-2 infection in lung epithelia., Fondation pour la Recherche Med-icale (F.R.M.); European Union (EU); Horizon 2020; ERC StG (INFLAME); ERC StG (ANTIViR); French Ministry of Health; Goupe-ment Interregional de Recherche Clinique et d’Innovation Sud-Ouest Outre-Mer (PHRCI 2020 IMMUNOMARK-COV); LABEX; CIFRE PhD Fellowship; Investissement d'Avenir and foundation Bettencourt; InvivoGen; Mali Ministry of Education; Vaincre La Mucoviscidose (VLM); InvivoGen

Published
2022

15. Surgical complications and clinical outcomes after dose-escalated trimodality therapy for non-small cell lung cancer in the era of intensity-modulated radiotherapy

Author

Liu, Kevin X., primary, Sierra-Davidson, Kailan, additional, Tyan, Kevin, additional, Orlina, Lawrence T., additional, Marcoux, J. Paul, additional, Kann, Benjamin H., additional, Kozono, David E., additional, Mak, Raymond H., additional, White, Abby, additional, and Singer, Lisa, additional

Published
2021
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18. FP01.05 The ASCENT Trial: A Phase II Study of Neoadjuvant/Adjuvant Afatinib, Chemoradiation +/- Surgery for Stage III EGFR-Mutant NSCLC

Author

Piper-Vallillo, A., primary, Mak, R., additional, Lanuti, M., additional, Muzikansky, A., additional, Rotow, J., additional, Jänne, P., additional, Mino-Kenudson, M., additional, Swanson, S., additional, Wright, C., additional, Kozono, D., additional, Marcoux, J., additional, Piotrowska, Z., additional, Willers, H., additional, and Sequist, L., additional

Published
2021
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21. Turnaround Time of Plasma Next-Generation Sequencing in Thoracic Oncology Patients: A Quality Improvement Analysis

Author

Lee, Yi, primary, Clark, Evan W., additional, Milan, Marina S.D., additional, Champagne, Christine, additional, Michael, Kesi S., additional, Awad, Mark M., additional, Barbie, David A., additional, Cheng, Michael L., additional, Kehl, Kenneth L., additional, Marcoux, J. Paul, additional, Rabin, Michael S., additional, Rotow, Julia K., additional, Sands, Jacob M., additional, Jänne, Pasi A., additional, and Oxnard, Geoffrey R., additional

Published
2020
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22. Reply to Letter

Author

Sohn, N, Marcoux, J, Mycyk, T, Krahn, J, and Meng, Q H

Published
2010

25. Penalty predictability enhanced: FERC modifies its enforcement guidelines

Author

Marcoux, J. Michel

Subjects
United States. Federal Energy Regulatory Commission -- Energy policy -- Economic policy, United States. Congress -- Economic policy -- Energy policy, Electric utilities -- Laws, regulations and rules -- Evaluation, Natural gas -- Pipe lines, Government regulation, Business, Petroleum, energy and mining industries, Telecommunications industry
Abstract

In 2005, the U.S. Congress increased Federal Energy Regulatory Commission (FERC) penalty authority over the country's natural gas pipeline and electric utility industries. Five years later, FERC implemented September 2010 [...]

Published
2010

26. Presumed power: growing gas storage depends on fair regulatory treatment

Author

Marcoux, J. Michel

Subjects
Natural gas -- Supply and demand -- Prices and rates -- Forecasts and trends, Gas industry -- Prices and rates -- Industry forecasts -- Forecasts and trends, Market trend/market analysis, Company pricing policy, Business, Petroleum, energy and mining industries, Telecommunications industry
Abstract

Customers of natural gas storage facilities use them to stockpile a lower-cost gas supply inventory when demand weakens. Later, they draw down the inventory to avoid higher, spot-market gas commodity [...]

Published
2010

29. Penalty predictability: bringing fairness to FERC enforcement

Author

Marcoux, J. Michel

Subjects
Government regulation, Electric utilities -- Laws, regulations and rules, Natural gas -- Pipe lines, United States. Federal Energy Regulatory Commission -- Energy policy -- Laws, regulations and rules
Abstract

Seeking to add consistency, transparency, and fairness to its enforcement process, the Federal Energy Regulatory Commission (FERC) proposed civil penalty guidelines in its March 18, 2010, interim policy statement for [...]

Published
2010

34. Chapter 12 The cat model of spinal injury

Author

Rossignol, S., primary, Chau, C., additional, Giroux, N., additional, Brustein, E., additional, Bouyer, L., additional, Marcoux, J., additional, Langlet, C., additional, Barthelémy, D., additional, Provencher, J., additional, Leblond, H., additional, Babeau, H., additional, and Reader, T.A., additional

Published
2002
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35. Proving intent to manipulate markets: should FERC look to all Securities and Exchange Commission precedent for a model?

Author

Marcoux, J. Michael

Subjects
United States. Federal Energy Regulatory Commission -- Management, Securities fraud -- Laws, regulations and rules, Securities industry -- Laws, regulations and rules, Securities industry, Government regulation, Company business management, Business, Petroleum, energy and mining industries, Telecommunications industry, Securities Exchange Act
Abstract

New regulations from the Federal Energy Regulatory Commission (FERC) to prevent energy industry market manipulation take deep root in securities industry law. Modeled in part on the Securities Exchange Act [...]

Published
2006

37. Day of decision for FERC: how will the commission answer Congress' call for energy market transparency?

Author

Marcoux, J. Michel

Subjects
United States -- Energy policy, Energy industry -- Industry forecasts, Business, Petroleum, energy and mining industries, Telecommunications industry, Energy Policy Act of 2005
Abstract

With the Energy Policy Act of 2005 (EPACT), Congress gives a big boost to Federal Energy Regulatory Commission (FERC) efforts to encourage greater transparency of price formation and restore confidence [...]

Published
2005

38. The storage conundrum: Congress allows market-based rates. How will FERC respond?

Author

Marcoux, J. Michel

Subjects
United States. Federal Energy Regulatory Commission -- Laws, regulations and rules, Gas industry -- Laws, regulations and rules, Government regulation, Business, Petroleum, energy and mining industries, Telecommunications industry
Abstract

Under Natural Gas Act (NGA) Sections 4(a) and (b), and 5(a), natural gas companies engaged in interstate commerce must charge just and reasonable, non-discriminatory rates) When the Federal Energy Regulatory [...]

Published
2005

39. Changes in the pipeline: a new FERC decision veers away from congressional intent not to burden intrastate pipelines with interstate policies

Author

Marcoux, J. Michael

Subjects
United States. Federal Energy Regulatory Commission -- Laws, regulations and rules, Natural gas -- Pipe lines, Natural gas -- Laws, regulations and rules, Government regulation, Business, Petroleum, energy and mining industries, Telecommunications industry
Abstract

State commissions can set intrastate natural gas pipeline transportation rates except when the intrastate pipeline moves gas in interstate commerce. Then, the Federal Energy Regulatory Commission (FERC) regulates the rates [...]

Published
2004

40. The coming transmission credit crisis: how can transmission providers safely serve noncreditworthy customers?

Author

Marcoux, J. Michel and Blackburn, Thomas L.

Subjects
Electric power transmission -- Finance, Electric power transmission -- Forecasts and trends, Market trend/market analysis, Company financing, Business, Petroleum, energy and mining industries, Telecommunications industry
Abstract

In 2001, with California and Midwest energy markets in turmoil, the Federal Energy Regulatory Commission (FERC) warned that such market uncertainty had sounded a 'wake-up call' for electricity transmission providers [...]

Published
2003

44. Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

Author

Farago, Anna F., primary, Yeap, Beow Y., additional, Stanzione, Marcello, additional, Hung, Yin P., additional, Heist, Rebecca S., additional, Marcoux, J. Paul, additional, Zhong, Jun, additional, Rangachari, Deepa, additional, Barbie, David A., additional, Phat, Sarah, additional, Myers, David T., additional, Morris, Robert, additional, Kem, Marina, additional, Dubash, Taronish D., additional, Kennedy, Elizabeth A., additional, Digumarthy, Subba R., additional, Sequist, Lecia V., additional, Hata, Aaron N., additional, Maheswaran, Shyamala, additional, Haber, Daniel A., additional, Lawrence, Michael S., additional, Shaw, Alice T., additional, Mino-Kenudson, Mari, additional, Dyson, Nicholas J., additional, and Drapkin, Benjamin J., additional

Published
2019
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46. More FERC investigation risks: new transparency practice turns confidentiality on its head

Author

Marcoux, J. Michel

Subjects
United States. Federal Energy Regulatory Commission -- Laws, regulations and rules -- Cases, Investigations -- Cases -- Laws, regulations and rules, Company legal issue, Government regulation, Investigation, Business, Petroleum, energy and mining industries, Telecommunications industry
Abstract

The Federal Energy Regulatory Commission (FERC) now authorizes the director of its Office of Enforcement (OE) to cause the names of subjects under investigation, and summaries of their alleged wrongful [...]

Published
2011

47. A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo

Author

Raimondi, S., Porcari R., Pp, Mangione, ., Verona, G., Marcoux J., S, Giorgetti, ., Taylor, G. w., Ellmerich, S., Ballico, M., Zanini, S., Pardon, E., Al Shawi, R., Simons, J. p., Corazza, A., Fogolari, F., Leri, Manuela, Stefani, Massimo, Bucciantini, Monica, Gillmore, J. d., Hawkins, P. N., Valli, M., Stoppini, M., Robinson, C. v., Steyaert, J., Esposito, G, and Bellotti, V.

Subjects
nanobody, b2-microglobulina, amiloidosi
Published
2017

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