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1. Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy: a randomised controlled trial

Author

Acosta, Jesús, Alberola, María J., Alcón, Amalia, Almajano, Rosa, Álvarez, Carlos, Anaya, Rafael, Aragón, Cristian, Argilaga, Marta, Arocas, Blanca, Ayas, Begoña, Balandrón, Victor, Bárcena, Elizabeth, Bejarano, Natalia, Belmonte, Luis, Berges, Vanesa, Guillén Bermejo, Maria, Cabadas, Rafael, Cabrera, Sergio, Callejas, Raquel, Carbonell, Jose, Carrizo, Juan, Castillo, Jesús, Charco, Pedro, Colás, Ana, Colomina, Lorena, Cotter, Laura, Cruz, Patricia, Cuervo, Javier, Del Castillo, Gema, Del Río, Elena, Delgado, Juan, Dexeus, Carlos, Díaz, Rubén, Dinu, Mandalina, Duca, Alejandro, Duque, Paula, Echarri, Gemma, Fabra, Patricia, Fernández, Carmen, Florea, Raluca, Forcada, Pilar, Fuentes, Isabel, Garcés, Cristina, Del Valle, Santiago G., García, Beatriz, García, Esther, García, María, García, Mercedes, Garrigues, Beatriz, Garutti, Ignacio, Gil, Fernando, González, Domingo, Gracia, Alejandro, Gracia, Estefanía, Granell, Manuel, Guerra, Yessica, Gutierrez, Andrea, Hernando, Julia, Herrero, Miriam, Ibáñez, Maite, Imaz, Inés, Izquierdo, Blanca, Jurado, Ana, Lafuente, Noelia, Lascorz, Laura, León, Irene, López, Antonio, López-Herrera, Daniel, Lozano, Angels, Marcos, José M., Martínez, Graciela, Martínez, Sara, Mata, Esperanza, Matoses, Salomé, Mendez, Rosa, Merino, María, Millaruelo, Andrés, Molina, Carlos R., Monleon, Berta, Montenegro, Omar M., Mugarra, Ana, Muñoz, Jose L., Oliver-Forniés, Pablo, Ortega, Manuel, Palencia, María A., Parera, Ana, Pastor, Ernesto, del Mar Pérez, Maria, Pérez, Sara, Pestaña, David, Piñol, Santiago, Puig, Jaume, Pujol, Roger, Quesada, Natividad, Ramón, Ana, Rego, Consuelo, Reviriego, Laura, Rodríguez, Rayco, Romero, Blanca, Romero, Esther, Roselló, Marta, Rovira, Lucas, Ruiz, Lola, Sancho, Laura, Sandín, Francisco, Serralta, Ferran, Tres, Eva, Valls, Paola, Vaquero, Laura, Varela, Marina, Vega, Victor, Viguera, Laura, Villazala, Rubén, Villena, Abigail, Visiedo, Sara, Ferrando, Carlos, Aldecoa, César, Unzueta, Carmen, Belda, F. Javier, Librero, Julián, Tusman, Gerardo, Suárez-Sipmann, Fernando, Peiró, Salvador, Pozo, Natividad, Brunelli, Andrea, Gallego, Clara, Rodríguez, Aurelio, García, Jose Ignacio, Díaz-Cambronero, Oscar, Balust, Jaume, Redondo, Francisco J., de la Matta, Manuel, Gallego-Ligorit, Lucía, Hernández, Javier, Martínez, Pascual, Pérez, Ana, Leal, Sonsoles, Alday, Enrique, Monedero, Pablo, González, Rafael, Mazzirani, Guido, Aguilar, Gerardo, López-Baamonde, Manuel, Felipe, Mar, Torrente, Jara, Valencia, Lucia, Varón, Viviana, Sánchez, Sergio, Rodríguez, Benigno, Martín, Ana, India, Inmaculada, Azparren, Gonzalo, Molina, Rodrigo, Villar, Jesús, and Soro, Marina

Published
2020
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2. Efficacy of Tocilizumab in Patients With Moderate-to-Severe Corticosteroid-Resistant Graves Orbitopathy: A Randomized Clinical Trial

Author

Gomez-Reino, Juan J., Maneiro, Jose, Tome Martinez de Rituerto, Maria A., Pampin, Eva Perez, Perez-Moreiras, Jose V., Alvarez, Alejandro, Lopez, Angel Romo, Troyano, Juan, Niño, Cristina, Vico, Eva, Montañez Zorrilla, Maria C., Sanz, Marco Sales, Martín Ucero, Ana M., Revenga, Marcelino, Gregori, Enrique España, Pérez Lazaro, Antonia M., Todoli, José A., Gonzalez Alejos, Alba M., Rodríguez Alvarez, Fernando M., Díaz, César, Cubero Marcos, José M., Castillo Laguarta, Jesús M., Polo, Angel Dominguez, Lavilla, Laura, Ginés, Cilia Peralta, Cabello, Aurora del Estad, Gómez Escobar, Antonio J., Díaz, Concepción, Sarabia, Federico Navarro, Hernández, Tomás Martín, Sorroche, María Gessa, Navarro, Elena, Rubio, Esteban, Blandón, Rafael Villanueva, Maiquez, María P., Maneiro, Jose R., Perez-Pampin, Eva, Romo Lopez, Angel, del Estad Cabello, Aurora, Gessa Sorroche, María, España Gregori, Enrique, and Sales-Sanz, Marco

Published
2018
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20. Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy: a randomised controlled trial

Author

Ferrando, Carlos, primary, Aldecoa, César, additional, Unzueta, Carmen, additional, Belda, F. Javier, additional, Librero, Julián, additional, Tusman, Gerardo, additional, Suárez-Sipmann, Fernando, additional, Peiró, Salvador, additional, Pozo, Natividad, additional, Brunelli, Andrea, additional, Garutti, Ignacio, additional, Gallego, Clara, additional, Rodríguez, Aurelio, additional, García, Jose Ignacio, additional, Díaz-Cambronero, Oscar, additional, Balust, Jaume, additional, Redondo, Francisco J., additional, de la Matta, Manuel, additional, Gallego-Ligorit, Lucía, additional, Hernández, Javier, additional, Martínez, Pascual, additional, Pérez, Ana, additional, Leal, Sonsoles, additional, Alday, Enrique, additional, Monedero, Pablo, additional, González, Rafael, additional, Mazzirani, Guido, additional, Aguilar, Gerardo, additional, López-Baamonde, Manuel, additional, Felipe, Mar, additional, Mugarra, Ana, additional, Torrente, Jara, additional, Valencia, Lucia, additional, Varón, Viviana, additional, Sánchez, Sergio, additional, Rodríguez, Benigno, additional, Martín, Ana, additional, India, Inmaculada, additional, Azparren, Gonzalo, additional, Molina, Rodrigo, additional, Villar, Jesús, additional, Soro, Marina, additional, Acosta, Jesús, additional, Alberola, María J., additional, Alcón, Amalia, additional, Almajano, Rosa, additional, Álvarez, Carlos, additional, Anaya, Rafael, additional, Aragón, Cristian, additional, Argilaga, Marta, additional, Arocas, Blanca, additional, Ayas, Begoña, additional, Balandrón, Victor, additional, Bárcena, Elizabeth, additional, Bejarano, Natalia, additional, Belmonte, Luis, additional, Berges, Vanesa, additional, Guillén Bermejo, Maria, additional, Cabadas, Rafael, additional, Cabrera, Sergio, additional, Callejas, Raquel, additional, Carbonell, Jose, additional, Carrizo, Juan, additional, Castillo, Jesús, additional, Charco, Pedro, additional, Colás, Ana, additional, Colomina, Lorena, additional, Cotter, Laura, additional, Cruz, Patricia, additional, Cuervo, Javier, additional, Del Castillo, Gema, additional, Del Río, Elena, additional, Delgado, Juan, additional, Dexeus, Carlos, additional, Díaz, Rubén, additional, Dinu, Mandalina, additional, Duca, Alejandro, additional, Duque, Paula, additional, Echarri, Gemma, additional, Fabra, Patricia, additional, Fernández, Carmen, additional, Florea, Raluca, additional, Forcada, Pilar, additional, Fuentes, Isabel, additional, Garcés, Cristina, additional, Del Valle, Santiago G., additional, García, Beatriz, additional, García, Esther, additional, García, María, additional, García, Mercedes, additional, Garrigues, Beatriz, additional, Gil, Fernando, additional, González, Domingo, additional, Gracia, Alejandro, additional, Gracia, Estefanía, additional, Granell, Manuel, additional, Guerra, Yessica, additional, Gutierrez, Andrea, additional, Hernando, Julia, additional, Herrero, Miriam, additional, Ibáñez, Maite, additional, Imaz, Inés, additional, Izquierdo, Blanca, additional, Jurado, Ana, additional, Lafuente, Noelia, additional, Lascorz, Laura, additional, León, Irene, additional, López, Antonio, additional, López-Herrera, Daniel, additional, Lozano, Angels, additional, Marcos, José M., additional, Martínez, Graciela, additional, Martínez, Sara, additional, Mata, Esperanza, additional, Matoses, Salomé, additional, Mendez, Rosa, additional, Merino, María, additional, Millaruelo, Andrés, additional, Molina, Carlos R., additional, Monleon, Berta, additional, Montenegro, Omar M., additional, Muñoz, Jose L., additional, Oliver-Forniés, Pablo, additional, Ortega, Manuel, additional, Palencia, María A., additional, Parera, Ana, additional, Pastor, Ernesto, additional, del Mar Pérez, Maria, additional, Pérez, Sara, additional, Pestaña, David, additional, Piñol, Santiago, additional, Puig, Jaume, additional, Pujol, Roger, additional, Quesada, Natividad, additional, Ramón, Ana, additional, Rego, Consuelo, additional, Reviriego, Laura, additional, Rodríguez, Rayco, additional, Romero, Blanca, additional, Romero, Esther, additional, Roselló, Marta, additional, Rovira, Lucas, additional, Ruiz, Lola, additional, Sancho, Laura, additional, Sandín, Francisco, additional, Serralta, Ferran, additional, Tres, Eva, additional, Valls, Paola, additional, Vaquero, Laura, additional, Varela, Marina, additional, Vega, Victor, additional, Viguera, Laura, additional, Villazala, Rubén, additional, Villena, Abigail, additional, and Visiedo, Sara, additional

Published
2020
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22. Capacidad antiaterogénica y antiinflamatoria de las HDL en la hiperlipemia familiar combinada. Efectos del tratamiento hipolipemiante

Author

Cubero Marcos, José M., Pérez Pérez, Antonio, Leiva Hidalgo, Alberto de, and Universitat Autònoma de Barcelona. Departament de Medicina

Subjects
Hiperlipemia familiar combinada, Inflammation, HDL, Inflamación, lipids (amino acids, peptides, and proteins), Familial combined hyperlipemia, Inflamació, Ciències de la Salut, Hiperlipèmia familiar combinada
Abstract

La hiperlipemia familiar combinada (HFC) es la dislipemia genética más prevalente y se asocia a un elevado riesgo cardiovascular. El objetivo de esta tesis doctoral es definir las características del proceso inflamatorio y las modificaciones de las HDLs y LDLs asociadas a los cambios en el metabolismo lipídico en la HFC, e investigar los efectos de la terapéutica hipolipemiante sobre las mismas. Se realizaron dos estudios para evaluar estos objetivos. Inicialmente, un estudio transversal con 110 pacientes con HFC sin terapia hipolipemiante y 93 controles sin la dislipemia. El segundo, un estudio longitudinal de 57 de los pacientes del estudio transversal valorados antes y después del inicio del tratamiento hipolipemiante (seguimiento medio 98,33 + 60,31 días). Los resultados globales mostraron que la HFC se asocia a un estado de inflamación de bajo grado con elevación de la proteína C reactiva y de las quimioquinas leucocitarias sin modificación a corto plazo con el tratamiento hipolipemiante. Las LDL son modificadas oxidativamente y se favorece un fenotipo de partículas pequeñas y densas que son revertidas con el tratamiento. La disminución de LDL oxidada con el tratamiento parece depender más de la reducción de los niveles de LDL que de una menor susceptibilidad a oxidación producida por las HDL. Las HDL muestran un enriquecimiento en triglicéridos y en apo A-II y una reducción de apo A-I que mejoran con la terapia hipolipemiante. La actividad PAF-AH total y en las HDLs estaba aumentada y se corrigió con el tratamiento. Por tanto, la HFC se caracteriza por un estado de inflamación de bajo grado, cambios en el proteoma y lipidoma de las HDL y fenómenos prooxidativos. El tratamiento hipolipemiante a corto plazo mejora los cambios oxidativos y de las HDL sin un efecto significativo en el proceso inflamatorio. Combined familial hyperlipidemia (HFC) is the most prevalent genetic dyslipidemia and is associated with a high cardiovascular risk. The aim of this doctoral thesis is to define the characteristics of the inflammatory process and the modifications of HDLs and LDLs associated with changes in lipid metabolism in HFC, and to investigate the effects of lipid-lowering therapy on them. Two studies were conducted to evaluate these objectives. Initially, a cross-sectional study with 110 patients with HFC without lipid-lowering therapy and 93 controls without dyslipidemia. Afterwards, a longitudinal study of 57 of the patients participating in the cross-sectional study assessed before and after the start of lipid-lowering treatment (mean follow-up 98.33 + 60.31 days). The overall results showed that HFC is associated with a low-grade inflammation state including elevation of C-reactive protein and leukocyte chemokines plasma levels without short-term modification with lipid-lowering therapy. The LDL shows oxidative modifications and a phenotype of small and dense particles that are reversed with the treatment. The decrease in oxidized LDL with treatment seems to depend more on the reduction of LDL levels than on a lower susceptibility to oxidation produced by HDL. HDL show an enrichment in triglycerides and in apo A-II and a reduction of apo A-I that improve with lipid-lowering therapy. The PAF-AH total activity and in the HDLs was increased and corrected with the treatment. Therefore, HFC is characterized by a state of low-grade inflammation, changes in the proteome and lipidoma of HDL and pro-oxidative phenomena. The short-term lipid lowering treatment improves the oxidative and HDL changes without a significant effect on the inflammatory process.

Published
2018

25. Efficacy of Tocilizumab in Patients With Moderate-to-Severe Corticosteroid-Resistant Graves Orbitopathy: A Randomized Clinical Trial

Author

Perez-Moreiras, Jose V., primary, Gomez-Reino, Juan J., additional, Maneiro, Jose R., additional, Perez-Pampin, Eva, additional, Romo Lopez, Angel, additional, Rodríguez Alvarez, Fernando M., additional, Castillo Laguarta, Jesús M., additional, del Estad Cabello, Aurora, additional, Gessa Sorroche, María, additional, España Gregori, Enrique, additional, Sales-Sanz, Marco, additional, Maneiro, Jose, additional, Tome Martinez de Rituerto, Maria A., additional, Pampin, Eva Perez, additional, Perez-Moreiras, Jose V., additional, Alvarez, Alejandro, additional, Lopez, Angel Romo, additional, Troyano, Juan, additional, Niño, Cristina, additional, Vico, Eva, additional, Montañez Zorrilla, Maria C., additional, Sanz, Marco Sales, additional, Martín Ucero, Ana M., additional, Revenga, Marcelino, additional, Gregori, Enrique España, additional, Pérez Lazaro, Antonia M., additional, Todoli, José A., additional, Gonzalez Alejos, Alba M., additional, Díaz, César, additional, Cubero Marcos, José M., additional, Polo, Angel Dominguez, additional, Lavilla, Laura, additional, Ginés, Cilia Peralta, additional, Cabello, Aurora del Estad, additional, Gómez Escobar, Antonio J., additional, Díaz, Concepción, additional, Sarabia, Federico Navarro, additional, Hernández, Tomás Martín, additional, Sorroche, María Gessa, additional, Navarro, Elena, additional, Rubio, Esteban, additional, Blandón, Rafael Villanueva, additional, and Maiquez, María P., additional

Published
2018
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30. Adoptions in a co-operative population of Carrion Crow Corvus corone corone.

Author

Marcos, José M. and Baglione, Vittorio

Abstract

Provides data on the occurrence of adoptions in a Spanish cooperative population of Carrion Crow Corvus corone corone. Observation that adoptions occurred at low rate, probably as a result of a mistake in early offspring recognition; Indication that the data fit uncomfortably into the intergenerational conflict hypothesis.

Published
2003
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