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2. Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0612) for Parkinson's disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial

Author

Afshari, Mitra, Amelin, Alexander, Arkadir, David, Badarny, Samih, Balaguer Martinez, Ernest, Bogucki, Andrzej, Boyd, James, Buyan Dent, Laura, Carroll, Camille, Chaudhuri, Kallol Ray, Cooney, Jeffrey, Corbillé, Anne-Gaëlle, Danaila, Teodor, De Pandis, Maria Francesca, Dethy, Sophie, Dhall, Rohit, Djaldetti, Ruth, Durif, Franck, Flitman, Stephen, Freire Alvarez, Eric, Goudreau, John, Grandas Perez, Francisco, Gurevich, Tanya, Isa, Arnaldo, Juncos, Jorge L, Kanchana, Sulada, Klodowska-Duda, Gabriela, Koziorowski, Dariusz, Kulisevsky Bojarski, Jaime, Lopez Lozano, Juan, Luo, Lan, Lytvynenko, Nataliya, Marconi, Roberto, Marques, Ana-Raquel, Martinez Castrillo, Juan Carlos, Martinez Torres, Irene, Mentreddi, Aashoo, Mir Rivera, Pablo, Moskovko, Sergii, Neryanova, Yuliya, Onofrj, Marco, Ostrem, Jill, Pacchetti, Claudio, Pavese, Nicola, Pellicano, Clelia, Revuelta, Gonzalo, Rodrigues, Ana Margarida, Rodriguez, Ramon, Rudzinska, Monika, Sarwar, Nighat, Schwartzbard, Julie, Scorr, Laura, Slevin, John, Slobodin, Tatyana, Spalletta, Gianfranco, Tagliati, Michele, Tai, Yen, Tessitore, Alessandro, Valkovic, Peter, Verhagen, Leo, Vostrikova, Elena, Yahalom, Gilad, Zalyalova, Zuleykha, Zarubova, Katerina, Zhukova, Irina, Espay, Alberto J, Stocchi, Fabrizio, Pahwa, Rajesh, Albanese, Alberto, Ellenbogen, Aaron, Ferreira, Joaquim J, Giladi, Nir, Hassin-Baer, Sharon, Hernandez-Vara, Jorge, Isaacson, Stuart H, Kieburtz, Karl, LeWitt, Peter A, Lopez-Manzanares, Lydia, Olanow, C Warren, Poewe, Werner, Sarva, Harini, Yardeni, Tami, Adar, Liat, Salin, Laurence, Lopes, Nelson, Sasson, Nissim, Case, Ryan, and Rascol, Olivier

Published
2024
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4. Movement Disorders Emergencies

Author

Colosimo, Carlo, Galletti, Francesca, Cossu, Giovanni, Marconi, Roberto, Eleopra, Roberto, Micieli, Giuseppe, editor, Cavallini, Anna, editor, Ricci, Stefano, editor, Consoli, Domenico, editor, and Edlow, Jonathan A., editor

Published
2021
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6. Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0612) for Parkinson's disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial

Author

Espay, Alberto J, primary, Stocchi, Fabrizio, additional, Pahwa, Rajesh, additional, Albanese, Alberto, additional, Ellenbogen, Aaron, additional, Ferreira, Joaquim J, additional, Giladi, Nir, additional, Gurevich, Tanya, additional, Hassin-Baer, Sharon, additional, Hernandez-Vara, Jorge, additional, Isaacson, Stuart H, additional, Kieburtz, Karl, additional, LeWitt, Peter A, additional, Lopez-Manzanares, Lydia, additional, Olanow, C Warren, additional, Poewe, Werner, additional, Sarva, Harini, additional, Yardeni, Tami, additional, Adar, Liat, additional, Salin, Laurence, additional, Lopes, Nelson, additional, Sasson, Nissim, additional, Case, Ryan, additional, Rascol, Olivier, additional, Afshari, Mitra, additional, Amelin, Alexander, additional, Arkadir, David, additional, Badarny, Samih, additional, Balaguer Martinez, Ernest, additional, Bogucki, Andrzej, additional, Boyd, James, additional, Buyan Dent, Laura, additional, Carroll, Camille, additional, Chaudhuri, Kallol Ray, additional, Cooney, Jeffrey, additional, Corbillé, Anne-Gaëlle, additional, Danaila, Teodor, additional, De Pandis, Maria Francesca, additional, Dethy, Sophie, additional, Dhall, Rohit, additional, Djaldetti, Ruth, additional, Durif, Franck, additional, Flitman, Stephen, additional, Freire Alvarez, Eric, additional, Goudreau, John, additional, Grandas Perez, Francisco, additional, Isa, Arnaldo, additional, Juncos, Jorge L, additional, Kanchana, Sulada, additional, Klodowska-Duda, Gabriela, additional, Koziorowski, Dariusz, additional, Kulisevsky Bojarski, Jaime, additional, Lopez Lozano, Juan, additional, Luo, Lan, additional, Lytvynenko, Nataliya, additional, Marconi, Roberto, additional, Marques, Ana-Raquel, additional, Martinez Castrillo, Juan Carlos, additional, Martinez Torres, Irene, additional, Mentreddi, Aashoo, additional, Mir Rivera, Pablo, additional, Moskovko, Sergii, additional, Neryanova, Yuliya, additional, Onofrj, Marco, additional, Ostrem, Jill, additional, Pacchetti, Claudio, additional, Pavese, Nicola, additional, Pellicano, Clelia, additional, Revuelta, Gonzalo, additional, Rodrigues, Ana Margarida, additional, Rodriguez, Ramon, additional, Rudzinska, Monika, additional, Sarwar, Nighat, additional, Schwartzbard, Julie, additional, Scorr, Laura, additional, Slevin, John, additional, Slobodin, Tatyana, additional, Spalletta, Gianfranco, additional, Tagliati, Michele, additional, Tai, Yen, additional, Tessitore, Alessandro, additional, Valkovic, Peter, additional, Verhagen, Leo, additional, Vostrikova, Elena, additional, Yahalom, Gilad, additional, Zalyalova, Zuleykha, additional, Zarubova, Katerina, additional, and Zhukova, Irina, additional

Published
2024
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7. Comprehensive Cardiovascular Management of Myotonic Dystrophy Type 1 Patients: A Report from the Italian Neuro-Cardiology Network

Author

Russo, Vincenzo, primary, Antonini, Giovanni, additional, Massa, Roberto, additional, Casali, Carlo, additional, Mauriello, Alfredo, additional, Martino, Anna, additional, Marconi, Roberto, additional, Garibaldi, Matteo, additional, Franciosa, Pasquale, additional, Zecchin, Massimo, additional, Gaudio, Carlo, additional, D’Andrea, Antonello, additional, and Strano, Stefano, additional

Published
2024
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8. Comprehensive Cardiovascular Management of Myotonic Dystrophy Type 1 Patients: A Report from Italian Neuro-Cardiology Network

Author

Russo, Vincenzo, primary, Antonini, Giovanni, additional, Massa, Roberto, additional, Carlo, Casali, additional, Mauriello, Alfredo, additional, Martino, Annamaria, additional, Marconi, Roberto, additional, Garibaldi, Matteo, additional, Franciosa, Pasquale, additional, Zecchin, Massimo, additional, Gaudio, Carlo, additional, D’Andrea, Antonello, additional, and Strano, Stefano, additional

Published
2024
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10. Appropriateness, safety, and effectiveness of “drip and ship” teleconsultation model in Southeastern Tuscany: a feasibility study

Author

Gallerini, Simone, Marsili, Luca, Groccia, Vincenzo, Bartalucci, Manuele, Innocenti, Eleonora, Marotti, Caterina, Pieri, Sergio, Plewnia, Katrin, Scarpini, Chiara, Keeling, Elizabeth G., Gregorio, Massimo, Geraci, Simone, Zocchi, Mauro, Cirinei, Marco, De Stefano, Teresa, Galassi, Stefania, Martini, Giuseppe, Tassi, Rossana, Bracco, Sandra, Cerase, Alfonso, Dami, Stefano, Panzardi, Giuseppe, Breggia, Mauro, and Marconi, Roberto

Published
2020
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12. Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy–Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study

Author

Antolini, Laura, DiFrancesco, Jacopo C., Zedde, Marialuisa, Basso, Gianpaolo, Arighi, Andrea, Shima, Atsushi, Cagnin, Annachiara, Caulo, Massimo, Carare, Roxana O., Charidimou, Andreas, Cirillo, Mario, Di Lazzaro, Vincenzo, Ferrarese, Carlo, Giossi, Alessia, Inzitari, Domenico, Marcon, Michela, Marconi, Roberto, Ihara, Masafumi, Nitrini, Ricardo, Orlandi, Berardino, Padovani, Alessandro, Pascarella, Rosario, Perini, Francesco, Perini, Giulia, Sessa, Maria, Scarpini, Elio, Tagliavini, Fabrizio, Valenti, Raffaella, Vázquez-Costa, Juan Francisco, Villarejo-Galende, Alberto, Hagiwara, Yuta, Ziliotto, Nicole, and Piazza, Fabrizio

Published
2021
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13. Movement Disorders Emergencies

Author

Colosimo, Carlo, primary, Galletti, Francesca, additional, Cossu, Giovanni, additional, Marconi, Roberto, additional, and Eleopra, Roberto, additional

Published
2020
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14. PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability

Author

Fevga, Christina, Tesson, Christelle, Carreras Mascaro, Ana, Courtin, Thomas, Van Coller, Riaan, Sakka, Salma, Ferraro, Federico, Farhat, Nouha, Bardien, Soraya, Damak, Mariem, Carr, Jonathan, Ferrien, Melanie, Boumeester, Valerie, Hundscheid, Jasmijn, Grillenzoni, Nicola, Kessissoglou, Irini A., Kuipers, Demy J.S., Quadri, Marialuisa, Agid, Yves, Anheim, Mathieu, Borg, Michel, Brice, Alexis, Broussolle, Emmanuel, Corvol, Jean Christophe, Damier, Philippe, Defebvre, Luc, Dürr, Alexandra, Durif, Franck, Houeto, Jean Luc, Krack, Paul, Klebe, Stephan, Lesage, Suzanne, Lohmann, Ebba, Martinez, Maria, Mangone, Graziella, Mariani, Louise Laure, Pollak, Pierre, Rascol, Olivier, Tison, François, Tranchant, Christine, Verin, Marc, Viallet, François, Vidailhet, Marie, Emre, Murat, Hanagasi, Hasmet, Bilgic, Basar, Lu, Bedia Marangozog, Benmahdjoub, Mustapha, Arezki, Mohammed, Bouchetara, Sofiane A., Benhassine, Traki, Tazir, Meriem, Djebara, Mouna Ben, Gouider, Riadh, Romdhan, Sawssan Ben, Mhiri, Chokri, Bouhouche, Ahmed, Bonifati, Vincenzo, Mandemakers, Wim, Kievit, Anneke J.A., Boon, Agnita J.W., Ferreira, Joaquim J., Guedes, Leonor Correia, Hanagasi, Hasmet A., Tufekcioglu, Zeynep, Elibol, Bulent, Dog.u, Okan, Gultekin, Murat, Chien, Hsin F., Barbosa, Egberto, Jardim, Laura Bannach, Rieder, Carlos R.M., Chang, Hsiu Chen, Lu, Chin Song, Wu-Chou, Yah Huei, Yeh, Tu Hsueh, Lopiano, Leonardo, Tassorelli, Cristina, Pacchetti, Claudio, Comi, Cristoforo, Raudino, Francesco, Bertolasi, Laura, Tinazzi, Michele, Bonizzato, Alberto, Ferracci, Carlo, Marconi, Roberto, Guidi, Marco, Onofrj, Marco, Thomas, Astrid, Vanacore, Nicola, Meco, Giuseppe, Fabrizio, Edito, Fabbrini, Giovanni, Berardelli, Alfredo, Stocchi, Fabrizio, Vacca, Laura, Barone, Paolo, Picillo, Marina, De Michele, Giuseppe, Criscuolo, Chiara, De Mari, Michele, Dell'aquila, Claudia, Iliceto, Giovanni, Toni, Vincenzo, Trianni, Giorgio, Saddi, Valeria, Cossu, Gianni, Melis, Maurizio, Hassan, Bassem A., Breedveld, Guido J., Erasmus University Medical Center [Rotterdam] (Erasmus MC), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Génétique médicale [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Faculty of Health Sciences [Pretoria], University of Pretoria [South Africa], Hopital Habib Bourguiba - Habib Bourguiba Hospital [Sfax], Stellenbosch University, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Motivation, cerveau et comportement = Motivation, Brain and Behavior [ICM Paris] (MBB), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Tesson, Christelle, Clinical Genetics, and Neurology

Subjects
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, intellectual disability, PTPA, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], PPP2R4, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, parkinsonism, PP2A
Abstract

The protein phosphatase 2A complex (PP2A), the major Ser/Thr phosphatase in the brain, is involved in a number of signalling pathways and functions, including the regulation of crucial proteins for neurodegeneration, such as alpha-synuclein, tau and LRRK2. Here, we report the identification of variants in the PTPA/PPP2R4 gene, encoding a major PP2A activator, in two families with early-onset parkinsonism and intellectual disability. We carried out clinical studies and genetic analyses, including genome-wide linkage analysis, whole-exome sequencing, and Sanger sequencing of candidate variants. We next performed functional studies on the disease-associated variants in cultured cells and knock-down of ptpa in Drosophila melanogaster. We first identified a homozygous PTPA variant, c.893T>G (p.Met298Arg), in patients from a South African family with early-onset parkinsonism and intellectual disability. Screening of a large series of additional families yielded a second homozygous variant, c.512C>A (p.Ala171Asp), in a Libyan family with a similar phenotype. Both variants co-segregate with disease in the respective families. The affected subjects display juvenile-onset parkinsonism and intellectual disability. The motor symptoms were responsive to treatment with levodopa and deep brain stimulation of the subthalamic nucleus. In overexpression studies, both the PTPA p.Ala171Asp and p.Met298Arg variants were associated with decreased PTPA RNA stability and decreased PTPA protein levels; the p.Ala171Asp variant additionally displayed decreased PTPA protein stability. Crucially, expression of both variants was associated with decreased PP2A complex levels and impaired PP2A phosphatase activation. PTPA orthologue knock-down in Drosophila neurons induced a significant impairment of locomotion in the climbing test. This defect was age-dependent and fully reversed by L-DOPA treatment. We conclude that bi-allelic missense PTPA variants associated with impaired activation of the PP2A phosphatase cause autosomal recessive early-onset parkinsonism with intellectual disability. Our findings might also provide new insights for understanding the role of the PP2A complex in the pathogenesis of more common forms of neurodegeneration.

Published
2023
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15. LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study

Author

Bonifati, Vincenzo, Quadri, Marialuisa, Mandemakers, Wim, Kievit, Anneke J.A., Boon, Agnita J.W., Rood, Janneke P.A, Vergouw, Leonie J.M., de Jong, Frank J., van Swieten, John C., Mattace-Raso, Francesco U.S., Leenders, Klaus L., Ferreira, Joaquim J., Correia Guedes, Leonor, Puschmann, Andreas, Ygland, Emil, Nilsson, Christer, Chien, Hsin F., Barbosa, Egberto, Bannach Jardim, Laura, Rieder, Carlos R.M., Chang, Hsiu-Chen, Lu, Chin-Song, Wu-Chou, Yah-Huei, Yeh, Tu-Hsueh, Lopiano, Leonardo, Tassorelli, Cristina, Pacchetti, Claudio, Riboldazzi, Giulio, Bono, Giorgio, Comi, Cristoforo, Padovani, Alessandro, Borroni, Barbara, Raudino, Francesco, Fincati, Emiliana, Tinazzi, Michele, Bonizzato, Alberto, Ferracci, Carlo, Dalla Libera, Alessio, Abbruzzese, Giovanni, Cortelli, Pietro, Capellari, Sabina, Marconi, Roberto, Guidi, Marco, Onofrj, Marco, Thomas, Astrid, Vanacore, Nicola, Meco, Giuseppe, Fabrizio, Edito, Fabbrini, Giovanni, Berardelli, Alfredo, Stocchi, Fabrizio, Vacca, Laura, Barone, Paolo, Picillo, Marina, De Michele, Giuseppe, Criscuolo, Chiara, De Mari, Michele, Dell'Aquila, Claudia, Iliceto, Gianni, Toni, Vincenzo, Trianni, Giorgio, Gagliardi, Monica, Annesi, Grazia, Quattrone, Aldo, Saddi, Valeria, Cossu, Gianni, Melis, Maurizio, Grochowska, Martyna M, Masius, Roy, Geut, Hanneke, Breedveld, Guido J, Kuipers, Demy, Minneboo, Michelle, Vergouw, Leonie J M, Carreras Mascaro, Ana, Yonova-Doing, Ekaterina, Simons, Erik, Zhao, Tianna, Di Fonzo, Alessio B, Parchi, Piero, Melis, Marta, Brouwer, Rutger W W, Heijsman, Daphne, Ingrassia, Angela M T, Calandra Buonaura, Giovanna, Rood, Janneke P, Rozemuller, Annemieke J, Sarchioto, Marianna, Fen Chien, Hsin, Olgiati, Simone, Boon, Agnita J W, Hoogers, Susanne E, Ghazvini, Mehrnaz, IJpma, Arne S, van IJcken, Wilfred F J, Nicholl, David J, Kievit, Anneke J, Majoor-Krakauer, Danielle, van Swieten, John C, de Jong, Frank J, Ferreira, Joaquim J, Cossu, Giovanni, and van de Berg, Wilma D J

Published
2018
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25. The validity and reliability of the Italian Olfactory Identification Test (IOIT) in healthy subjects and in Parkinson's disease patients

Author

Maremmani, Carlo, Rossi, Giuseppe, Tambasco, Nicola, Fattori, Bruno, Pieroni, Aldo, Ramat, Silvia, Napolitano, Alessandro, Vanni, Paola, Serra, Palma, Piersanti, Patrizia, Zanetti, Michela, Coltelli, Maila, Orsini, Massimo, Marconi, Roberto, Purcaro, Carlo, Rossi, Aroldo, Calabresi, Paolo, and Meco, Giuseppe

Published
2012
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26. Bipartição gástrica para tratamento paliativo de câncer de estômago avançado

Author

Marconi Roberto Lemos Meira, Romulo Silva Furtado, Raquel Nogueira Cordeiro, Diego Laurentino Lima, and Jose Júlio Farias Arruda

Subjects
medicine.medical_specialty, Surgical team, Nausea, business.industry, Cancer, General Medicine, medicine.disease, Inferior vena cava, Surgery, medicine.anatomical_structure, medicine.vein, Epigastrium, medicine, Vomiting, Abdomen, medicine.symptom, business, Gastric Hemorrhage
Abstract

Introdução: O Câncer Gástrico (CG) é o quarto câncer mais comumente diagnosticado e a segunda principal causa de morte por câncer em todo o mundo. A sobrevida mediana raramente ultrapassa os 12 meses e, na forma metastática, a sobrevida de 5 anos é inferior a 10%. A maioria dos pacientes apresenta-se em estágios avançados da doença, frequentemente com tumores distais obstrutivos e irressecáveis, demandando tratamento paliativo, cujo objetivo é dar ao doente maior qualidade de vida. Relato do caso: Paciente, sexo masculino, 59 anos, aposentado, tabagista e etilista. Procurou Serviço de Pronto Atendimento com queixa de vômitos pós-prandiais, associados a dor abdominal epigástrica e perda de aproximadamente 8kg nos últimos 20 dias. Ao exame físico, foi identificada massa palpável em regiões de epigastro e mesogastro, dolorosa e de consistência sólida. Paciente teve como hipótese diagnóstica inicial Síndrome Pilórica secundária a neoplasia. A tomografia de abdome mostrou presença de um processo expansivo sólido, de aspecto infiltrativo, envolvendo a parede gástrica, na região do antro, inclusive promovendo sinais de estase líquida. Nódulo heterogêneo, entrando em contiguidade com a veia cava inferior, chegando a medir cerca de 1,1x0,9 cm, em seus maiores diâmetros. Diante do diagnóstico de adenocarcinoma gástrico avançado, com invasão de veia cava inferior, pâncreas e metástase hepática, sem proposta cirúrgica ou oncológica curativa, foi optado por nutrir o paciente de forma parenteral. A equipe cirúrgica optou pela cirurgia de bipartição gástrica com gastrojejuno anastomose, sob a técnica aberta, com duração aproximada de 90 minutos. Paciente recebeu alta hospitalar no quarto DPO, em boas condições clínicas, boa aceitação de dieta via oral, sem náuseas ou vômitos. Paciente veio a falecer 16 meses após a cirurgia devido a hemorragia digestiva alta secundária ao tumor avançado e sepse. Conclusão: a técnica da bipartição pode ser considerada uma técnica efetiva e segura, proporcionando um menor número de sintomas como náusea e vômitos, manutenção de dieta via oral e qualidade de vida para os pacientes sem proposta curativa.

Published
2020
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27. Acral injury as the first manifestation of colon cancer: case report

Author

Thiago Alexandre Martins Marques, Ana Carolina Branco Neves Silva, Marconi Roberto Lemos Meira, Mariana de Albuquerque Borges, Raquel Nogueira Cordeiro, and Diego Laurentino Lima

Subjects
Pathology, medicine.medical_specialty, Gastrointestinal tumors, Bone lesion, business.industry, Colorectal cancer, Medicine, Bone metastasis, Gastrointestinal cancer, business, medicine.disease, Metastasis, Metastatic lesion
Abstract

During the diagnosis of the primary CRC, about 20% of patients have already developed metastatic diseases, and the most commons metastatic sites include the liver and lungs. Bone metastasis (BM) is rare and is reported only in 10–15% of patients with CRC. We describe a case of a patient who presented with a bone lesion on his right foot which was later diagnosed as a metastatic lesion from a gastrointestinal cancer.

Published
2020
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28. Fístula gastrobrônquica como complicação rara de gastroplastia para obesidade: relato de dois casos Gastrobronchial fistula as a rare complication of gastroplasty for obesity: a report of two cases

Author

Josemberg Marins Campos, Luciana Teixeira de Siqueira, Marconi Roberto de Lemos Meira, Álvaro Antônio Bandeira Ferraz, Edmundo Machado Ferraz, and Murilo José de Barros Guimarães

Subjects
Fístula, Abscesso pulmonar, Abscesso subfrênico, Obesidade, Endoscopia, Fistula, Lung abscess, Subphrenic abscess, Obesity, Endoscopy, Diseases of the respiratory system, RC705-779
Abstract

A fístula gastrobrônquica é uma condição rara como complicação decorrente de cirurgia da obesidade. O seu manejo exige a participação ativa de um pneumologista, o qual deve conhecer alguns aspectos dos principais tipos de cirurgia bariátrica. Neste relato, descrevemos dois casos de pacientes que apresentaram abscessos subfrênico e pulmonar recidivantes secundários a fístula no ângulo de His durante 19,5 meses, em média. Após o insucesso das relaparotomias, a cura foi obtida por meio da antibioticoterapia e, principalmente, por meio da estenostomia e da dilatação endoscópica, além do uso de clipes e cola de fibrina na fístula. Estas complicações pulmonares não devem ser tratadas isoladamente sem uma avaliação gastrintestinal pois isso pode resultar em piora do quadro respiratório, dificultando o manejo anestesiológico durante procedimentos endoscópicos.Gastrobronchial fistula is a rare condition as a complication following bariatric surgery. The management of this condition requires the active participation of a pulmonologist, who should be familiar with aspects of the main types of bariatric surgery. Herein, we report the cases of two patients who presented recurrent subphrenic and lung abscess secondary to fistula at the angle of His for an average of 19.5 months. After relaparotomy was unsuccessful, cure was achieved by antibiotic therapy and, more importantly, by stenostomy and endoscopic dilatation, together with the use of clips and fibrin glue in the fistula. These pulmonary complications should not be treated in isolation without a gastrointestinal evaluation since this can result in worsening of the respiratory condition, thus making anesthetic management difficult during endoscopic procedures.

Published
2007
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30. Tratamento laparoscópico de hérnias femoral e obturadora concomitantes

Author

Flavio Malcher, Marconi Roberto Lemos Meira, Diego Laurentino Lima, Raquel Nogueira Cordeiro, and Roberto Pabst Ramos

Subjects
General Medicine
Abstract

Paciente sexo feminino, 68 anos, com história de dor abdominal em Fossa Ilíaca esquerda e tumoração em região inguinal ipsilateral foi submetida a tratamento laparoscópico (TAPP). Durante procedimento cirúrgico, foram identificadas hérnia femoral e obturadora esquerdas. O conteudo herniário foi reduzido e uma tela de polipropileno foi colocada cobrindo os defeitos. Paciente evoluiu bem, sem dor no pós-operatório, recebendo alta no dia seguinte.

Published
2019
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33. Outcome After Acute Ischemic Stroke Treatment During Covid-19 Outbreak in South-East Tuscany

Author

Acampa, Maurizio, primary, Peresso, Valentina, additional, Lazzerini, Pietro Enea, additional, Domenichelli, Carlo, additional, Guideri, Francesca, additional, Tassi, Rossana, additional, Dami, Stefano, additional, Marconi, Roberto, additional, Iannelli, Giovanni, additional, Linoli, Giovanni, additional, Peppoloni, Giulia, additional, Nocentini, Simone, additional, Gallerini, Simone, additional, Cartocci, Alessandra, additional, Bracco, Sandra, additional, and Martini, Giuseppe, additional

Published
2021
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34. The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life

Author

Antonini, Angelo, Barone, Paolo, Marconi, Roberto, Morgante, Letterio, Zappulla, Salvatore, Pontieri, Francesco Ernesto, Ramat, Silvia, Ceravolo, Maria Gabriella, Meco, Giuseppe, Cicarelli, Giulio, Pederzoli, Massimo, Manfredi, Michela, Ceravolo, Roberto, Mucchiut, Marco, Volpe, Giampiero, Abbruzzese, Giovanni, Bottacchi, Edo, Bartolomei, Luigi, Ciacci, Giuseppe, Cannas, Antonino, Randisi, Maria Giovanna, Petrone, Alfredo, Baratti, Mario, Toni, Vincenzo, Cossu, Giovanni, Del Dotto, Paolo, Bentivoglio, Anna Rita, Abrignani, Michele, Scala, Rossana, Pennisi, Franco, Quatrale, Rocco, Gaglio, Rosa Maria, Nicoletti, Alessandra, Perini, Michele, Avarello, Tania, Pisani, Antonio, Scaglioni, Augusto, Martinelli, Paolo Emilio, Iemolo, Francesco, Ferigo, Laura, Simone, Pasqualino, Soliveri, Paola, Troianiello, Biagio, Consoli, Domenico, Mauro, Alessandro, Lopiano, Leonardo, Nastasi, Giuseppe, and Colosimo, Carlo

Published
2012
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35. Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders

Author

Marconi, Roberto, Antonini, Angelo, Barone, Paolo, Colosimo, Carlo, Avarello, Tania P., Bottacchi, Edo, Cannas, Antonino, Ceravolo, Maria G., Ceravolo, Roberto, Cicarelli, Giulio, Gaglio, Rosa M., Giglia, Luisa, Iemolo, Francesco, Manfredi, Michela, Meco, Giuseppe, Nicoletti, Alessandra, Pederzoli, Massimo, Petrone, Alfredo, Pisani, Antonio, Pontieri, Francesco E., Quatrale, Rocco, Ramat, Silvia, Scala, Rossana, Volpe, Giampiero, Zappulla, Salvatore, Bentivoglio, Anna Rita, Stocchi, Fabrizio, Trianni, Giorgio, Del Dotto, Paolo, De Gaspari, Danilo, Grasso, Lucia, Morgante, Francesca, Santangelo, Gabriella, Fabbrini, Giovanni, and Morgante, Letterio

Published
2012
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37. Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study

Author

Colosimo, Carlo, Morgante, Letterio, Antonini, Angelo, Barone, Paolo, Avarello, Tania P., Bottacchi, Edo, Cannas, Antonino, Ceravolo, Maria Gabriella, Ceravolo, Roberto, Cicarelli, Giulio, Gaglio, Rosa M., Giglia, Luisa, Iemolo, Francesco, Manfredi, Michela, Meco, Giuseppe, Nicoletti, Alessandra, Pederzoli, Massimo, Petrone, Alfredo, Pisani, Antonio, Pontieri, Francesco E., Quatrale, Rocco, Ramat, Silvia, Scala, Rossana, Volpe, Giampiero, Zappulla, Salvatore, Bentivoglio, Anna Rita, Stocchi, Fabrizio, Trianni, Giorgio, Del Dotto, Paolo, Simoni, Lucia, Marconi, Roberto, and and PRIAMO STUDY GROUP

Published
2010
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40. Tratamento conservador na síndrome de Boerhaave

Author

Geraldo José Paraíso Wanderley, Diego Laurentino Lima, Marconi Roberto Lemos Meira, Camila Maria Nascimento Firme, and Raquel Nogueira Cordeiro

Subjects
General Medicine
Abstract

A Síndrome de Boerhaave, ruptura esofagiana espontânea, é uma doença de difícil diagnóstico, por não apresentar manifestações clínicas específicas e seus achados de sinais e sintomas sugerirem outros diagnósticos diferenciais. É uma síndrome que apresenta elevadas taxas de mortalidade e o principal fator para esse desfecho desfavorável é o atraso entre a perfuração do esófago e o tratamento adequado. Exames de imagem são fundamentais para elucidação diagnostica, contribuindo para o tratamento precoce. Diversas modalidades de tratamento estão descritas na literatura, dentre elas, o tratamento cirúrgico, endoscópico ou manejo conservador. A cirurgia ainda é considerada padrão-ouro no tratamento da maioria dos casos. Contudo, apesar de poucos casos descritos na literatura, o manejo conservador, sem necessidade de cirurgia em um primeiro momento, pode ser indicado para determinados grupos de pacientes, com sucesso. Relatamos um caso de paciente com diagnóstico de Síndrome de Boerhaave tratado conservadoramente, com excelente resultado. O tratamento conservador da perfuração esofágica é uma boa alternativa para determinados perfis de paciente e deve ser bem indicado para que se obtenha êxito.

Published
2018
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42. Psychosis associated to Parkinsonʼs disease in the early stages: relevance of cognitive decline and depression

Author

Morgante, Letterio, Colosimo, Carlo, Antonini, Angelo, Marconi, Roberto, Meco, Giuseppe, Pederzoli, Massimo, Pontieri, Francesco E, Cicarelli, Giulio, Abbruzzese, Giovanni, Zappulla, Salvatore, Ramat, Silvia, Manfredi, Michela, Bottacchi, Edo, Abrignani, Michele, Berardelli, Alfredo, Cozzolino, Autilia, Paradiso, Claudio, De Gaspari, Danilo, Morgante, Francesca, and Barone, Paolo

Published
2012
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45. Reduced Admissions for Cerebrovascular Events During COVID-19 Outbreak in Italy

Author

Sacco, Simona, primary, Ricci, Stefano, additional, Ornello, Raffaele, additional, Eusebi, Paolo, additional, Petraglia, Luca, additional, Toni, Danilo, additional, Rota, Eugenia, additional, Bruzzone, Gianluca, additional, Testa, Lucia, additional, Bongioanni, Roberta, additional, Rosso, Mara, additional, Labate, Carmelo, additional, Tarletti, Roberto, additional, Cantello, Roberto, additional, Fleetwood, Thomas, additional, Melis, Fabio, additional, Imperiale, Daniele, additional, Amarù, Salvatore, additional, Reggiani, Monica, additional, Ruiz, Luigi, additional, Cipriano, Elia, additional, Ferrandi, Delfina, additional, Julita, Patrizia, additional, Africa, Liana, additional, Meinieri, Piero, additional, Grasso, Maria Federica, additional, Servo, Serena, additional, Cavallo, Roberto, additional, Chianale, Gigliola, additional, Naldi, Andrea, additional, Cerrato, Paolo, additional, Rubino, Elisa, additional, Giossi, Alessia, additional, Puglisi, Valentina, additional, Vinciguerra, Luisa, additional, Santilli, Ignazio, additional, Bordo, Bianca Maria, additional, Marcheselli, Simona, additional, Bottini, Julia, additional, D’Alessandro, Caterina Mariotto, additional, Micieli, Giuseppe, additional, Cavallini, Anna, additional, Canavero, Isabella, additional, Muscia, Francesco, additional, Nuzzaco, Graziamaria, additional, Ciccone, Alfonso, additional, Silvestrelli, Giorgio, additional, Salmaggi, Andrea, additional, Sangalli, Davide, additional, Zanferrari, Carla, additional, Fanucchi, Simona, additional, Ranieri, Michela, additional, Beretta, Simone, additional, Ferrarese, Carlo, additional, Pasini, Francesco, additional, Santangelo, Francesco, additional, Checcarelli, Nicoletta, additional, Beretta, Sandro, additional, Bazzi, Paola, additional, Camerlingo, Massimo, additional, Tognozzi, Marcello, additional, Caneve, Giorgio, additional, Adami, Alessandro, additional, Quatrale, Rocco, additional, Critelli, Adriana, additional, Bartolomei, Luigi, additional, Masato, Maela, additional, Perini, Francesco, additional, De Boni, Antonella, additional, Disco, Caterina, additional, Baracchini, Claudio, additional, Pieroni, Alessio, additional, Lerario, Roberto, additional, Russo, Monia, additional, Polo, Alberto, additional, Danese, Alessandra, additional, Valentinis, Luca, additional, Baldi, Antonio, additional, Tonello, Simone, additional, Paladin, Francesco, additional, Tonon, Agnese, additional, Bonetti, Bruno, additional, Cappellari, Manuel, additional, Teatini, Francesco, additional, Dossi, Roberto Currò, additional, Franchini, Enrica, additional, Giometto, Bruno, additional, Bignamini, Valeria, additional, Manganotti, Paolo, additional, Naccarato, Marcello, additional, Gigli, Gian Luigi, additional, Lorenzut, Simone, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Rana, Michele, additional, Gentile, Carolina, additional, Tassinari, Tiziana, additional, Sugo, Annalisa, additional, Saia, Valentina, additional, Balestrino, Maurizio, additional, Coccia, Alberto, additional, Finocchi, Cinzia, additional, Valzania, Franco, additional, Zedde, Maria Luisa, additional, Toschi, Giulia, additional, Longoni, Marco, additional, Paolucci, Matteo, additional, Tugnoli, Valeria, additional, Querzani, Pietro, additional, Padroni, Marina, additional, Meletti, Stefano, additional, Bigliardi, Guido, additional, Dall’Acqua, Maria Luisa, additional, Zini, Andrea, additional, Gentile, Mauro, additional, Migliaccio, Ludovica, additional, Chiti, Alberto, additional, Tassi, Rossana, additional, Martini, Giuseppe, additional, Nencini, Patrizia, additional, Lamassa, Maria, additional, Mancuso, Michelangelo, additional, Orlandi, Giovanni, additional, Ferrari, Elena, additional, Marconi, Roberto, additional, Gallerini, Simone, additional, Groggia, Vincenzo, additional, Volpi, Gino, additional, Menichetti, Chiara, additional, Spolveri, Stefano, additional, Silvestrini, Mauro, additional, Viticchi, Giovanna, additional, Buratti, Laura, additional, Pelliccioni, Giuseppe, additional, Potente, Eleonora, additional, Mazzoli, Tatiana, additional, Marsili, Erica, additional, Cenciarelli, Silvia, additional, Picchioni, Antonella, additional, Costantini, Franco, additional, Colosimo, Carlo, additional, Paciaroni, Maurizio, additional, Caso, Valeria, additional, Rasura, Maurizia, additional, Beccia, Mario, additional, Falcone, Nicola, additional, Di Stefano, Marisa, additional, Cecconi, Emanuela, additional, Anticoli, Sabrina, additional, Pezzella, Francesca Romana, additional, Mangiardi, Marilena, additional, Plocco, Maurizio, additional, Magarelli, Maria, additional, Saggese, Carlo Emanuele, additional, Berto, Irene, additional, Altavista, Maria Concetta, additional, Roberti, Cinzia, additional, Diomedi, Marina, additional, Sallustio, Fabrizio, additional, Rocco, Alessandro, additional, Cupini, Letizia Maria, additional, Bonaffini, Novella, additional, De Angelis, Maria Vittoria, additional, Digiovanni, Anna, additional, Rispoli, Marianna, additional, Orlandi, Berardino, additional, Santis, Federica De, additional, Colangeli, Enrico, additional, Blasio, Francesco Di, additional, Carmine, Caterina Di, additional, Tocco, Pierluigi, additional, Melis, Maurizio, additional, Moller, Jessica, additional, Saddi, Valeria, additional, Manca, Antonio, additional, Baule, Antonio, additional, Caddeo, Antonello, additional, Iorio, Nicola, additional, Napoletano, Rosa, additional, di Gregorio, Maria, additional, Volpe, Giampiero, additional, D’Onofrio, Florindo, additional, Spitaleri, Daniele, additional, Barbarini, Leonardo, additional, Barbagallo, Gaetano, additional, Caggiula, Marcella, additional, Ardito, Bonaventura, additional, Noia, Domenico Di, additional, Viesti, Pietro Di, additional, Leone, Maurizio Angelo, additional, Inchingolo, Vincenzo, additional, Petruzzellis, Marco, additional, Rizzo, Federica, additional, Savarese, Mariantonietta, additional, Petrone, Alfredo, additional, Galati, Franco, additional, Arcudi, Luciano, additional, Branca, Damiano, additional, Aridon, Paolo, additional, Arnao, Valentina, additional, Musolino, Rosa, additional, Dell’Aera, Cristina, additional, Francalanza, Isabella, additional, Grimaldi, Luigi, additional, Gammino, Matilde, additional, Giordano, Antonello, additional, Zelante, Giuseppe, additional, Sanzaro, Enzo, additional, and Gasparro, Antonio, additional

Published
2020
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50. The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinsonʼs disease

Author

Barone, Paolo, Antonini, Angelo, Colosimo, Carlo, Marconi, Roberto, Morgante, Letterio, Avarello, Tania P., Bottacchi, Eugenio, Cannas, Antonino, Ceravolo, Gabriella, Ceravolo, Roberto, Cicarelli, Giulio, Gaglio, Roberto M., Giglia, Rosa M., Iemolo, Francesco, Manfredi, Michela, Meco, Giuseppe, Nicoletti, Alessandra, Pederzoli, Massimo, Petrone, Alfredo, Pisani, Antonio, Pontieri, Francesco E., Quatrale, Rocco, Ramat, Silvia, Scala, Rosanna, Volpe, Giuseppe, Zappulla, Salvatore, Bentivoglio, Anna Rita, Stocchi, Fabrizio, Trianni, Giorgio, and Dotto, Paolo Del

Published
2009
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