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4 results on '"Marco-Betes V"'

1. Nivolumab en linfoma de Hodgkin recaído/refractario: experiencia en Aragón

Author

Auria Caballero, C., Marco Betes, V, De Poo Rodriguez, V, Murillo Florez, I, Lacalle Aicua, L., Dourdil Sahun, V, Mayor Perez, L., Amarilla Lanzas, I, Pimentel Feliciano, A., Rubio Escuin, R., Martinez Lazaro, B., Marco Amigot, J., and Palomera Bernal, L.

Abstract

PB-111 Introducción: En el linfoma de Hodgkin (LH) las alteraciones genéticas del cromosoma 9p24.1 de la célula de Reed-Sternberg, causan una sobreexpresión del ligando 1 de muerte programada (PDL-1), que conducen a una evasión del sistema inmune y resistencia terapéutica. Para pacientes refractarios primarios o que recaen después de un trasplante autólogo y de tratamiento con Brentuxumab, existen pocas posibilidades. Nivolumab es una opción para conseguir respuesta y poder realizar trasplante alogénico. Presentamos la experiencia de 4 casos clínicos de Aragón. Paciente y métodos: Caso 1: Varón de 69 años diagnosticado de LH celularidad mixta estadio IIIA en Junio de 2005. 1ª línea: ABVDx6 y radioterapia mediastínica con RC. 2ª línea: por recidiva cervical: Ifosfamida, Vinorelbina y Prednisona con RC. 3ª línea: afectación cervical y retoperitoneal: cisplatino, citarabina y dexametasona más radioterapia cervical con RC. 4ª línea: MOPPx4 y Rituximab Gemcitabina con RC. Autotrasplante en Noviembre de 2011 con RC. 5ª línea: por afectación cervical, retroperitoneal, esplénica e iliaco: Brentuximabx4 y por mala respuesta se añade Bendamustinax3 con RC. A los 4 meses recaída agresiva con amplia afectación ósea y esplénica. Se administra Nivolumab. Caso 2: Varón de 32 años con LH esclerosis nodular IIIB en 2015. Tratado en otro país con ABVDx6 con RC y recaída al año. Después BEACOPPx4, GEMOXx4 y DHAPx4 sin resultado. En nuestro país Brentuximabx4 con progresión. Se administra Nivolumab. Caso3: Varón de 56 años con LH esclerosis nodular IVsB, en Septiembre de 2017. 1ª línea: ABVDx3 y AVDx3 con refractariedad y neumonitis por Bleomicina.2ª línea:ESAHPx2 con persistencia y toxicidad. 3ª línea: Brentuximabx4 con RC, consolidando con Brentuximab- Bendamustinax4. Progresión posterior rápida. Se administra Nivolumab. Caso 4:varón de 32 años diagnosticado en Abril 2016 de LH depleción linfocítica IVB (ósea). 1ª línea:ABVDx6 con RC. Recaída Mayo 2018.2ª línea: ESHAPx2 con persistencia.3ª línea: Brentuximabx4 con progresión. Se administra Nivolumab. Resultados: En el caso 1 se consigue RC con ...

Published
2019

2. Fluorescence in situ hybridization of TP53 for the detection of chromosome 17 abnormalities in myelodysplastic syndromes

Author

Sanchez-Castro, J, Marco-Betes, V, Gomez-Arbones, X, Garcia-Cerecedo, T, Lopez, R, Talavera, E, Fernandez-Ruiz, S, Adema, V, Marugan, I, Luno, E, Sanzo, C, Vallespi, T, Arenillas, L, Marco-Buades, J, Batlle, A, Buno, I, Martin-Ramos, M, Blazquez-Rios, B, Collado-Nieto, R, Vargas, M, Gonzalez-Martinez, T, Sanz, G, Sole, F, Spanish Grp Mds Study GESMD, and Spanish Grp Clinical Cytogenetics

Subjects
FISH, Myelodysplastic syndromes, chromosome 17, cytogenetics
Abstract

Conventional G-banding cytogenetics (CC) detects chromosome 17 (chr17) abnormalities in 2% of patients with de novo myelodysplastic syndromes (MDS). We used CC and fluorescence in situ hybridization (FISH) (LSI p53/17p13.1) to assess deletion of 17p in 531 patients with de novo MDS from the Spanish Group of Hematological Cytogenetics. FISH detected - 17 or 17p abnormalities in 13 cases (2.6%) in whom no 17p abnormalities were revealed by CC: 0.9% of patients with a normal karyotype, 0% in non-informative cytogenetics, 50% of patients with a chr17 abnormality without loss of 17p and 4.7% of cases with an abnormal karyotype not involving chr17. Our results suggest that applying FISH of 17p13 to identify the number of copies of the TP53 gene could be beneficial in patients with a complex karyotype. We recommend using FISH of 17p13 in young patients with a normal karyotype or non-informative cytogenetics, and always in isolated del(17p)

Published
2015

3. Feasibility of allogeneic hematopoietic stem cell transplantation in advanced age.

Author

Fernandez-Luis S, Gomez Lamas D, Cerezo Martin JM, Mora Barrios JM, Yañez San Segundo L, Sanchez Escamilla M, Fernandez-Escalada N, Calvo Sanchez JA, Fernandez Garcia S, Dominguez-Garcia JJ, Colorado Araujo M, Lopez-Duarte M, Martin-Sanchez G, Insunza Gaminde A, Romon Alonso JI, Lobeira Rubio R, Arroyo Rodriguez JL, Rueda Ciller B, Hermosilla Fernandez M, Marco Betes V, Ocio EM, and Bermudez Rodriguez A

Subjects
Humans, Aged, Middle Aged, Feasibility Studies, Retrospective Studies, Recurrence, Transplantation Conditioning methods, Leukemia, Myeloid, Acute complications, Hematopoietic Stem Cell Transplantation adverse effects, Graft vs Host Disease etiology
Abstract

Although it is known that increasing age is associated with increased morbidity and mortality in allogeneic transplantation (allo-HSCT), individualization of the process may allow to perform it in progressively older patients.This study analyzed the outcome of 97 patients older than 60 years with a first allo-HSCT performed at our institution between 2011 and 2019.Median age was 66 years (range 60-79) and 15.4% were older than 70 years. The most frequent diagnosis was acute leukemia (50.5%), and 58.8% received a myeloablative conditioning. With a median follow-up of 33.9 months (range 7.9-111.5), at 3-years overall survival (OS) was 50%; progression-free survival (PFS), 46%; cumulative incidence of relapse, 22%; and non-relapse mortality (NRM), 32%. There were no significant differences in OS (p = 0.415), PFS (p = 0.691), cumulative incidence of relapse (p = 0.357) or NRM (p = 0.658) between patients of 60-64 years (n = 37), 65-69 (n = 45) and ≥ 70 years (n = 15). No differences were observed either depending on the intensity of the conditioning regimen in terms of OS (p = 0.858), PFS (p = 0.729), cumulative incidence of relapse (p = 0.416) or NRM (p = 0.270).In conclusion, older adults can safely and effectively undergo allo-HSCT with proper patient selection and individualized transplantation procedures., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2024
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4. Multivariate time-dependent comparison of the impact of lenalidomide in lower-risk myelodysplastic syndromes with chromosome 5q deletion.

Author

Sánchez-García J, Del Cañizo C, Lorenzo I, Nomdedeu B, Luño E, de Paz R, Xicoy B, Valcárcel D, Brunet S, Marco-Betes V, García-Pintos M, Osorio S, Tormo M, Bailén A, Cerveró C, Ramos F, Diez-Campelo M, Such E, Arrizabalaga B, Azaceta G, Bargay J, Arilla MJ, Falantes J, Serrano-López J, and Sanz GF

Subjects
Adult, Aged, Aged, 80 and over, Disease Progression, Drug Evaluation methods, Erythrocyte Transfusion, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Lenalidomide, Male, Middle Aged, Multivariate Analysis, Myelodysplastic Syndromes genetics, Prognosis, Retrospective Studies, Thalidomide therapeutic use, Treatment Outcome, Angiogenesis Inhibitors therapeutic use, Chromosome Deletion, Chromosomes, Human, Pair 5 genetics, Myelodysplastic Syndromes drug therapy, Thalidomide analogs & derivatives
Abstract

The impact of lenalidomide treatment on long-term outcomes of patients with lower risk myelodysplastic syndromes (MDS) and chromosome 5q deletion (del(5q)) is unclear. This study used time-dependent multivariate methodology to analyse the influence of lenalidomide therapy on overall survival (OS) and acute myeloblastic leukaemia (AML) progression in 215 patients with International Prognostic Scoring System (IPSS) low or intermediate-1 risk and del(5q). There were significant differences in several relevant characteristics at presentation between patients receiving (n = 86) or not receiving lenalidomide (n = 129). The 5-year time-dependent probabilities of OS and progression to AML were 62% and 31% for patients receiving lenalidomide and 42% and 25% for patients not receiving lenalidomide; differences were not statistically significant in multivariate analysis that included all variables independently associated with those outcomes (OS, P = 0·45; risk of AML, P = 0·31, respectively). Achievement of RBC transfusion independency (P = 0·069) or cytogenetic response (P = 0·021) after lenalidomide was associated with longer OS in multivariate analysis. These data clearly show that response to lenalidomide results in a substantial clinical benefit in lower risk MDS patients with del(5q). Lenalidomide treatment does not appear to increase AML risk in this population of patients., (© 2014 John Wiley & Sons Ltd.)

Published
2014
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