1. Deep brain stimulation by optimized stimulators in a phenotypic model of dystonia: Effects of different frequencies
- Author
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Maria Paap, Stefanie Perl, Anika Lüttig, Franz Plocksties, Christoph Niemann, Dirk Timmermann, Christian Bahls, Ursula van Rienen, Denise Franz, Monique Zwar, Marco Rohde, Rüdiger Köhling, and Angelika Richter
- Subjects
High frequency stimulation ,Globus pallidus ,Subthalamic nucleus ,Dystonic dtsz hamster ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Deep brain stimulation (DBS) of the globus pallidus internus (GPi, entopeduncular nucleus, EPN, in rodents) has become important for the treatment of generalized dystonia, a severe and often intractable movement disorder. It is unclear if lower frequencies of GPi-DBS or stimulations of the subthalamic nucleus (STN) are of advantage. In the present study, the main objective was to examined the effects of bilateral EPN-DBS at different frequencies (130 Hz, 40 Hz, 15 Hz) on the severity of dystonia in the dtsz mutant hamster. In addition, STN stimulations were done at a frequency, proven to be effective by the present EPN-DBS in dystonic hamsters. In order to obtain precise bilateral electrical stimuli with magnitude of 50 μA, a pulse width of 60 μs and defined frequencies, it was necessary to develop a new optimized stimulator prior to the experiments. Since the individual highest severity of dystonic episodes is known to be reached within three hours after induction in dtsz hamsters, the duration of DBS was 180 min. During DBS with 130 Hz the severity of dystonia was significantly lower within the third hour than without DBS in the same animals (p
- Published
- 2021
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