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1. Simulation to become a better neurosurgeon. An international prospective controlled trial: The Passion study

Author

Claudia Fanizzi, Giovanni Carone, Alessandra Rocca, Roberta Ayadi, Veronika Petrenko, Cecilia Casali, Martina Rani, Marta Giachino, Lydia Viviana Falsitta, Enrico Gambatesa, Tommaso Francesco Galbiati, Eleonora Francesca Orena, Irene Tramacere, Nicole Irene Riker, Alessandro Mocca, Karl Schaller, Torstein Ragnar Meling, Francesco DiMeco, Alessandro Perin, Abdelaziz Najib, Adrian Ndroqi, Ana Tomas-Biosca, Anatoli Dimitrov, Antanas Budenas, Augustinas Fedaravicius, Aicha Ouchene, Dauleac Corentin, Djenaba Bah, Friedrich Erhart, Fahrudin Alić, Foughali Mehdi, Hajar Bechri, Jagoš Golubović, Julien Delaunois, Angela Rampini, Karolis Simaitis, Milan Lepic, Mirel Grada, Miroslav Fimic, Mohamed Amgad Elsayed Matter, Benachour Mohamed Safouane, Nebojsa Lasica, Olga Parras, Ran Xu, Demaerel Rik, Sandra Rutkowska, Margherita Castaldo, Tatyana Sarnecki, Angela Elia, Tobias Rossmann, Volodymyr Smolanka, Fatima Fakhro, Yinqian Wang, Yakun Yang, Hu Yeshuai, Bianca Baldassarre, Giuseppe Di Perna, Lei Qi, Ye Zhongxing, Alice Lucifero, Yuhao Zhao, Vittoria Cojazzi, Gianluca Mezzini, Bektaşoğlu Pınar Kuru, Marina Minichiello, Wenping Xiong, Yan Cui, Zhigang Tan, Yue Lu, Li Xu, Deng Gang, Xiaoyang Tao, Norbert Svoboda, Shiqiang Wang, Zhijie Zhoul, Chang Tao, Antonio D'Ammando, Fabio Grassia, Dong Wang, Jidong Sun, Yanwei Chen, Zongdang Wei, Andrew Stevens, Niko Njiric, Marco Cancedda, Ahmet Faruk Özdemir, Burak Tahmazoglu, Edoardo Porto, Namer Thana, Aqsa Adil, and Francesco Crisà

Subjects
Simulation, Neurosurgery, Training, Soft skills, Psychometric testing, Virtual reality, Neurology. Diseases of the nervous system, RC346-429
Abstract

Introduction: Surgical training traditionally adheres to the apprenticeship paradigm, potentially exposing trainees to an increased risk of complications stemming from their limited experience. To mitigate this risk, augmented and virtual reality have been considered, though their effectiveness is difficult to assess. Research question: The PASSION study seeks to investigate the improvement of manual dexterity following intensive training with neurosurgical simulators and to discern how surgeons' psychometric characteristics may influence their learning process and surgical performance. Material and methods: Seventy-two residents were randomized into the simulation group (SG) and control group (CG). The course spanned five days, commencing with assessment of technical skills in basic procedures within a wet-lab setting on day 1. Over the subsequent core days, the SG engaged in simulated procedures, while the CG carried out routine activities in an OR. On day 5, all residents' technical competencies were evaluated. Psychometric measures of all participants were subjected to analysis. Results: The SG demonstrated superior performance (p

Published
2024
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2. Diffuse gliomas in patients aged 55 years or over: A suggestion for IDH mutation testing

Author

Giampietro Pinna, Francesco Sala, Aldo Scarpa, Bruno Bonetti, Francesca Calabria, Giuseppe Ricciardi, Rekha Cappellini, Albino Eccher, Claudio Ghimenton, Valeria Barresi, Michele Simbolo, Renzo Mazzarotto, and Marco Cancedda

Subjects
IDH, Male, Methyltransferase, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Glioma, medicine, Biomarkers, Tumor, Humans, In patient, Genetic Testing, glioma, immunohistochemistry, prognosis, neoplasms, Aged, business.industry, Brain Neoplasms, General Medicine, Middle Aged, medicine.disease, Isocitrate Dehydrogenase, nervous system diseases, Idh mutation, Isocitrate dehydrogenase, 030220 oncology & carcinogenesis, Mutation, Cancer research, Immunohistochemistry, Female, Neurology (clinical), Oligodendroglioma, business, 030217 neurology & neurosurgery, Anaplastic astrocytoma
Abstract

Diffuse gliomas are defined on the isocitrate dehydrogenase (IDH) gene (IDH) mutational mutational status. The most frequent IDH mutation is IDH1 R132H, which is detectable by immunohistochemistry; other IDH mutations are rare (10%). IDH mutant gliomas have better prognosis. Further, IDH wild-type low-grade (II/III) gliomas have clinical behaviors similar to those of glioblastoma (GBM) and it was suggested that they are submitted to similar post-surgical treatment. The incidence of IDH mutant gliomas (2%) and that of GBMs with non-canonical IDH mutations (< 1%) are very low in patients ≥ 55 years. For this reason, it was suggested that immunohistochemistry against IDH1 R132H is sufficient to classify GBM as IDH wild-type in this age group. However, no indication was provided for IDH mutational testing in low-grade diffuse gliomas. To address this issue, 273 diffuse gliomas were tested for IDH1 R132H immunohistochemistry. 2/4 diffuse astrocytomas (DAs), 4/9 anaplastic astrocytomas (AAs), 2/256 GBMs, and 4/4 oligodendrogliomas had positive staining. No other IDH mutations were found in immuno-negative low-grade cases by DNA sequencing. To validate our findings, we considered 311 diffuse gliomas in patients ≥ 55 years in The Cancer Genome Atlas database. Fifty-five out of 311 gliomas had IDH R132H mutations (9/16 DAs; 8/48 AAs; 3/211 GBMs; 35/36 oligodendrogliomas), one DA, and one oligodendroglioma had other IDH mutations. IDH mutant gliomas had significantly higher frequency of O-6-methylguanine-DNA methyltransferase promoter methylation (P = 0.0008) and longer overall survival (P

Published
2019

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