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1. Latent class analysis of actigraphy within the depression early warning (DEW) longitudinal clinical youth cohort

Author

Lydia Sequeira, Pantea Fadaiefard, Jovana Seat, Madison Aitken, John Strauss, Wei Wang, Peter Szatmari, and Marco Battaglia

Subjects
Depression, Adolescence, Actigraphy, Activity, Sleep, Latent Class Analysis, Pediatrics, RJ1-570, Psychiatry, RC435-571
Abstract

Abstract Background Wearable-generated data yield objective information on physical activity and sleep variables, which, are in turn, related to the phenomenology of depression. There is a dearth of wearable-generated data regarding physical activity and sleep variables among youth with clinical depression. Methods Longitudinal (up to 24 months) quarterly collections of wearable-generated variables among adolescents diagnosed with current/past major depression. Latent class analysis was employed to classify participants on the basis of wearable-generated: Activity, Sleep Duration, and Sleep efficiency. The Patient Health Questionnaire adapted for adolescents (PHQ-9-A), and the Ruminative Response Scale (RRS) at study intake were employed to predict class membership. Results Seventy-two adolescents (72.5% girls) were recruited over 31 months. Activity, Sleep Duration, and Sleep efficiency were reciprocally correlated, and wearable-generated data were reducible into a finite number (3 to 4) of classes of individuals. A PHQ-A score in the clinical range (14 and above) at study intake predicted a class of low physical activity (Acceleration) and a class of shorter Sleep Duration. Limitations Limited power related to the sample size and the interim nature of this study. Conclusions This study of wearable-generated variables among adolescents diagnosed with clinical depression shows that a large amount of longitudinal data is amenable to reduction into a finite number of classes of individuals. Interfacing wearable-generated data with clinical measures can yield insights on the relationships between objective psychobiological measures and symptoms of adolescent depression, and may improve clinical management of depression.

Published
2024
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2. Multiple sclerosis and spasticity: the role of anaesthetic nerve blocks on rectus femoris muscle. When should stiff knee be treated with botulinum toxin?

Author

Alessio Baricich, Marco Battaglia, Margherita B. Borg, Alberto Loro, Paola Morlino, Lucia Cosenza, Michele Bertoni, Alessandro Picelli, Andrea Santamato, and Thierry Deltombe

Subjects
Botulinum toxin, Multiple sclerosis, Nerve blocks, Personalized medicine, Spasticity, Rehabilitation, Therapeutics. Pharmacology, RM1-950
Abstract

Objective: To compare the effect of rectus femoris diagnostic motor nerve blocks (DNB) with anaesthetics and rectus femoris muscle botulinum toxin (BoNT-A) injection in multiple sclerosis patients with unilateral stiff-knee gait. Design: Prospective observational study Subjects/Patients: Multiple sclerosis patients in stable condition. Methods: Patients underwent evaluation before and 1 hour after the anaesthetic block, and 1 month after the botulinum injection. Assessment included a 10-m walking test, a 6-minute walking test, a timed-up-and-go (TUG) test, and a Baseline Expanded Disability Status Scale (EDSS). Post-DNB and post-BoNT-A satisfaction was measured with the global assessment of efficacy scale. Results: Fourteen patients with unilateral stiff-knee gait due to multiple sclerosis underwent a DNB, among whom 13 received botulinum injections in the rectus femoris muscle after a satisfying test result. Positive post-DNB results correlated with significant functional improvements after BoNT-A. Higher EDSS and longer time from diagnosis correlated with poorer post-DNB and post-BoNT-A absolute outcomes. Conclusion: DNB showed predictive value for BoNT-A outcomes, especially in the case of worse functional status. It effectively predicted endurance and walking speed improvement, while TUG showed greater improvement after botulinum. In cases of uncertain therapeutic benefit, nerve blocks may provide a valuable diagnostic support, particularly in patients with lower functional status.

Published
2024
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3. Do Diagnostic Nerve Blocks Affect the Starting Dose of Botulinum Neurotoxin Type A for Spasticity? A Case-Control Study

Author

Mirko Filippetti, Stefano Tamburin, Rita Di Censo, Roberto Aldegheri, Elisa Mantovani, Stefania Spina, Marco Battaglia, Alessio Baricich, Andrea Santamato, Nicola Smania, and Alessandro Picelli

Subjects
botulinum neurotoxin, drug utilization, muscle spasticity, nerve block, ultrasonography, Medicine
Abstract

One of the aims of diagnostic nerve blocks is to identify the overactive muscles that lead to a specific spasticity pattern. However, to date, there is no evidence on how nerve blocks may affect botulinum neurotoxin-A (BoNT-A) dose in patients with spasticity. This case-control study aims to assess the role of diagnostic nerve block in defining BoNT-A starting dose at first treatment. Patients with upper and lower limb spasticity treated for the first time with BoNT-A were retrospectively divided into two groups: Group 1 (n = 43) was evaluated with clinical assessment and diagnostic nerve block; Group 2 (n = 56) underwent clinical assessment only. Group 1 was injected with higher BoNT-A doses in some muscles (i.e., flexor digitorum profundus, soleus), and received a higher BoNT-A cumulative dose with a larger number of injected muscles for some spasticity patterns (i.e., “clenched fist”, “flexed fingers”, “adducted thigh”). Diagnostic nerve block may help the clinician to optimize and personalize the BoNT-A dose since the first BoNT-A treatment.

Published
2024
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4. Role of Diagnostic Nerve Blocks in the Goal-Oriented Treatment of Spasticity with Botulinum Toxin Type A: A Case–Control Study

Author

Mirko Filippetti, Stefano Tamburin, Rita Di Censo, Martina Adamo, Elisa Manera, Jessica Ingrà, Elisa Mantovani, Salvatore Facciorusso, Marco Battaglia, Alessio Baricich, Andrea Santamato, Nicola Smania, and Alessandro Picelli

Subjects
spasticity, neurorehabilitation, diagnostic nerve block, botulinum neurotoxin-A, personalized treatment, goal-setting process, Medicine
Abstract

The goal-setting process is pivotal in managing patients with disabling spasticity. This case–control study assessed the role of diagnostic nerve blocks in guiding the goal-setting process within goal-targeted treatment of spasticity with botulinum neurotoxin-A. In this case–control study, patients with disabling spasticity underwent either a goal-setting process based on the patient’s needs and clinical evaluation (control group) or additional diagnostic nerve block procedures (case group). All enrolled patients underwent a focal treatment with botulinum neurotoxin-A injection and a 1-month follow-up evaluation during which goal achievement was quantified using the goal attainment scaling-light score system. Data showed a higher goal achievement rate in the case group (70%) than in the control group (40%). In conclusion, diagnostic nerve blocks may help guide the goal-setting process within goal-targeted treatment of spasticity with botulinum neurotoxin-A towards more realistic and achievable goals, thereby improving the outcomes of botulinum neurotoxin-A injection. Future studies should better explore the role of diagnostic nerve blocks to further personalize botulinum neurotoxin-A according to individual patients’ preferences and requirements.

Published
2024
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5. Pharmacokinetics of intranasal amiloride in healthy volunteers

Author

Venkata K. Yellepeddi, Marco Battaglia, Simon J. C. Davies, Jeremiah Alt, Shaelene Ashby, Paige Shipman, David J. Anderson, Joseph E. Rower, Christopher Reilly, Michael Voight, and Sabiha Rahman Mim

Subjects
Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270
Abstract

Abstract Anxiety and panic disorders are the most common mental illnesses in the United States and lack effective treatment options. Acid‐sending ion channels (ASICs) in the brain were shown to be associated with fear conditioning and anxiety responses and therefore are potential targets for treating panic disorder. Amiloride is an inhibitor of the ASICs in the brain and was shown to reduce panic symptoms in preclinical animal models. An intranasal formulation of amiloride will be highly beneficial to treat acute panic attacks due to advantages such as the rapid onset of action and patient compliance. The aim of this single‐center, open‐label trial was to evaluate the basic pharmacokinetics (PKs) and safety of amiloride after intranasal administration in healthy human volunteers at three doses (0.2, 0.4, and 0.6 mg). Amiloride was detected in plasma within 10 min of intranasal administration and showed a biphasic PK profile with an initial peak within 10 min of administration followed by a second peak between 4 and 8 h of administration. The biphasic PKs indicate an initial rapid absorption via the nasal pathway and later slower absorption by non‐nasal pathways. Intranasal amiloride exhibited a dose‐proportional increase in the area under the curve and did not exhibit any systemic toxicity. These data indicate that intranasal amiloride is rapidly absorbed and safe at the doses evaluated and can be further considered for clinical development as a portable, rapid, noninvasive, and nonaddictive anxiolytic agent to treat acute panic attacks.

Published
2023
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6. 'We survived the pandemic together': The impact of the COVID-19 pandemic on Canadian families living with chronic pain

Author

Tieghan Killackey, Sabine Soltani, Melanie Noel, Kathryn A. Birnie, Manon Choinière, M. Gabrielle Pagé, Lise Dassieu, Anaïs Lacasse, Chitra Lalloo, Patricia Poulin, Samina Ali, Krista Baerg, Marco Battaglia, Fiona Campbell, Vina Mohabir, Fareha Nishat, Rachel Kelly, Tatiana Lund, Ariane Isaac-Bertrand, Myles Benayon, Isabel Jordan, and Jennifer Stinson

Subjects
COVID-19, chronic pain, qualitative research, pediatric pain, Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950
Abstract

ABSTRACTIntroduction Pediatric chronic pain is a significant problem in Canada, affecting one in five youth. This study describes the impact of the pandemic on the experiences of Canadian families living with chronic pain through interviews with youth living with chronic pain, parents, and siblings.Methods Employing a qualitative descriptive design, in-depth semistructured interviews were completed with Canadian youth living with pain, as well as parents and siblings. Participants were not required to be related. Interviews were analyzed using a reflexive thematic analysis approach.Results Forty-four interviews were completed with 14 parents, 19 youth with chronic pain, and 11 siblings from across the country. Three key themes were developed: (1) absorbing and shifting: the toll of the pandemic on the family system (e.g., loss of coping mechanisms, shifting roles to respond to the pandemic), (2) social ambiguity and abandonment (e.g., social sacrifice and abandonment by the health care system), and (3) building community resilience: familial adaptation to the pandemic (e.g., family cohesion, confidence, and self-management).Discussion/Conclusions Youth, parents, and siblings reported that the pandemic impacted coping strategies across the family system. These results outline the challenges youth experienced managing their pain and overall health throughout the pandemic and the resilience built within families during this time. Going forward, it would be relevant to examine how racialized and structurally marginalized youth with chronic pain and their families experienced the pandemic. Future research should examine how unexpected benefits of the pandemic (e.g., increased confidence and self-management) may be sustained into the future.

Published
2023
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8. Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal study

Author

Alessio Baricich, Marco Battaglia, Daria Cuneo, Lucia Cosenza, Marzia Millevolte, Michela Cosma, Mirko Filippetti, Stefania Dalise, Valentina Azzollini, Carmelo Chisari, Stefania Spina, Nicoletta Cinone, Lorenza Scotti, Marco Invernizzi, Stefano Paolucci, Alessandro Picelli, and Andrea Santamato

Subjects
botulinum toxin, pain, spasticity, movement disorders, multiple sclerosis, spinal cord injury, Neurology. Diseases of the nervous system, RC346-429
Abstract

Botulinum toxin type A (BoNT-A) is the treatment of choice for focal spasticity, with a concomitant effect on pain reduction and improvement of quality of life (QoL). Current evidence of its efficacy is based mainly on post stroke spasticity. This study aims to clarify the role of BoNT-A in the context of non-stroke spasticity (NSS). We enrolled 86 patients affected by multiple sclerosis, spinal cord injury, and traumatic brain injury with clinical indication to perform BoNT-A treatment. Subjects were evaluated before injection and after 1, 3, and 6 months. At every visit, spasticity severity using the modified Ashworth scale, pain using the numeric rating scale, QoL using the Euro Qol Group EQ-5D-5L, and the perceived treatment effect using the Global Assessment of Efficacy scale were recorded. In our population BoNT-A demonstrated to have a significant effect in improving all the outcome variables, with different effect persistence over time in relation to the diagnosis and the number of treated sites. Our results support BoNT-A as a modifier of the disability condition and suggest its implementation in the treatment of NSS, delivering a possible starting point to generate diagnosis-specific follow-up programs.Clinical trial identifierNCT04673240.

Published
2023
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9. Adjunctive treatment and BoNT-A for post-stroke spasticity: Are we really focusing on the patient-centered goals?

Author

Alessio Baricich, Michele Bertoni, Andrea Santamato, Maurizio Osio, Giulio Gasperini, Alessandro Picelli, Franco Molteni, The Collaborative Working Group, Roberto Antonacci, Fabrizio Balestrieri, Marco Battaglia, Luciano Bissolotti, Margherita Borg, Marcello Campagnoli, Anna Castagna, Carmelo Chisari, Nicoletta Cinone, Claudio Corradini, Michela Cosma, Davide Dalla Costa, Paolo De Blasiis, Alessandra Del Felice, Giovanni Morone, Antonio Robecchi Majnardi, Francesco Sciarrini, Alessandro Specchia, and Carlo Trompetto

Subjects
stroke, spasticity, rehabilitation, botulinum toxin type A, adjunctive treatment, Neurology. Diseases of the nervous system, RC346-429
Published
2023
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10. Adolescent anxiety and pain problems: A joint, genome-wide investigation and pathway-based analysis.

Author

Sara Mascheretti, Diego Forni, Valentina Lampis, Luca Fumagalli, Stéphane Paquin, Till F M Andlauer, Wei Wang, Ginette Dionne, Mara R Brendgen, Frank Vitaro, Isabelle Ouellet-Morin, Guy Rouleau, Jean-Philippe Gouin, Sylvana Côté, Richard E Tremblay, Gustavo Turecki, Gabrielle Garon-Carrier, Michel Boivin, and Marco Battaglia

Subjects
Medicine, Science
Abstract

Both common pain and anxiety problems are widespread, debilitating and often begin in childhood-adolescence. Twin studies indicate that this co-occurrence is likely due to shared elements of risk, rather than reciprocal causation. A joint genome-wide investigation and pathway/network-based analysis of adolescent anxiety and pain problems can identify genetic pathways that subserve shared etiopathogenetic mechanisms. Pathway-based analyses were performed in the independent samples of: The Quebec Newborn Twin Study (QNTS; 246 twin pairs and 321 parents), the Longitudinal Study of Child Development in Quebec (QLSCD; n = 754), and in the combined QNTS and QLSCD sample. Multiple suggestive associations (p

Published
2023
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11. Determinants of long COVID among adults hospitalized for SARS-CoV-2 infection: A prospective cohort study

Author

Mattia Bellan, Daria Apostolo, Alice Albè, Martina Crevola, Nicolò Errica, Giacomo Ratano, Stelvio Tonello, Rosalba Minisini, Davide D’Onghia, Alessio Baricich, Filippo Patrucco, Patrizia Zeppegno, Carla Gramaglia, Piero Emilio Balbo, Giuseppe Cappellano, Sara Casella, Annalisa Chiocchetti, Elisa Clivati, Mara Giordano, Marcello Manfredi, Giuseppe Patti, David James Pinato, Chiara Puricelli, Davide Raineri, Roberta Rolla, Pier Paolo Sainaghi, Mario Pirisi, the No-More COVID study group, Errica Nicolò, Antonio Acquavivas, Luigi Mario Castello, Gian Carlo Avanzi, Giulia Baldon, Michela Barini, Marco Battaglia, Simone Bor, Vincenzo Cantaluppi, Alessandro Carriero, Daria Cuneo, Eleonora Gambaro, Luisa Isabella, Alberto Loro, Debora Marangon, Emanuele Mones, Elena Paracchini, and Stefano Tricca

Subjects
long COVID-19, SARS-CoV-2 infection, cytokines, DLCO, depression, Immunologic diseases. Allergy, RC581-607
Abstract

RationaleFactors associated with long-term sequelae emerging after the acute phase of COVID-19 (so called “long COVID”) are unclear. Here, we aimed to identify risk factors for the development of COVID-19 sequelae in a prospective cohort of subjects hospitalized for SARS-CoV-2 infection and followed up one year after discharge.MethodsA total of 324 subjects underwent a comprehensive and multidisciplinary evaluation one year after hospital discharge for COVID-19. A subgroup of 247/324 who consented to donate a blood sample were tested for a panel of circulating cytokines.ResultsIn 122 patients (37.8%) there was evidence of at least one persisting physical symptom. After correcting for comorbidities and COVID-19 severity, the risk of developing long COVID was lower in the 109 subjects admitted to the hospital in the third wave of the pandemic than in the 215 admitted during the first wave, (OR 0.69, 95%CI 0.51-0.93, p=0.01). Univariable analysis revealed female sex, diffusing capacity of the lungs for carbon monoxide (DLCO) value, body mass index, anxiety and depressive symptoms to be positively associated with COVID-19 sequelae at 1 year. Following logistic regression analysis, DLCO was the only independent predictor of residual symptoms (OR 0.98 CI 95% (0.96-0.99), p=0.01). In the subgroup of subjects with normal DLCO (> 80%), for whom residual lung damage was an unlikely explanation for long COVID, the presence of anxiety and depressive symptoms was significantly associated to persistent symptoms, together with increased levels of a set of pro-inflammatory cytokines: interferon-gamma, tumor necrosis factor-alpha, interleukin (IL)-2, IL-12, IL-1β, IL-17. In logistic regression analysis, depressive symptoms (p=0.02, OR 4.57 [1.21-17.21]) and IL-12 levels (p=0.03, OR 1.06 [1.00-1.11]) 1-year after hospital discharge were independently associated with persistence of symptoms.ConclusionsLong COVID appears mainly related to respiratory sequelae, prevalently observed during the first pandemic wave. Among patients with little or no residual lung damage, a cytokine pattern consistent with systemic inflammation is in place.

Published
2022
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12. Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19

Author

Mattia Bellan, Alessio Baricich, Filippo Patrucco, Patrizia Zeppegno, Carla Gramaglia, Piero Emilio Balbo, Alessandro Carriero, Chiara Santa Amico, Gian Carlo Avanzi, Michela Barini, Marco Battaglia, Simone Bor, Vincenzo Cantaluppi, Giuseppe Cappellano, Federico Ceruti, Annalisa Chiocchetti, Elisa Clivati, Mara Giordano, Daria Cuneo, Eleonora Gambaro, Eleonora Gattoni, Alberto Loro, Marcello Manfredi, Umberto Morosini, Francesco Murano, Elena Paracchini, Giuseppe Patti, David James Pinato, Davide Raineri, Roberta Rolla, Pier Paolo Sainaghi, Stefano Tricca, and Mario Pirisi

Subjects
Medicine, Science
Abstract

Abstract Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363–369] days, 79 patients (39.5%) reported at least one symptom. A DLCO

Published
2021
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13. Sensitivity to BSM effects in the Higgs p T spectrum within SMEFT

Author

Marco Battaglia, Massimiliano Grazzini, Michael Spira, and Marius Wiesemann

Subjects
Beyond Standard Model, Hadron-Hadron scattering (experiments), Higgs physics, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The study of Higgs boson production at large transverse momentum is one of the new frontiers for the LHC Higgs physics programme. This paper considers boosted Higgs production in the Standard Model Effective Field Theory (SMEFT). We focus on the gluon fusion and t t ¯ $$ \overline{t} $$ H production processes and study the effects of three dimension-6 operators: the top Yukawa operator, the gluon-Higgs effective coupling and the chromomagnetic dipole operator of the top quark. We perform a detailed study of the sensitivity of current and future LHC data to the corresponding Wilson coefficients, consistently accounting for their renormalisation group evolution. We compare the sensitivities obtained with only linear and linear + quadratic terms in the SMEFT by using the spectrum shape and the addition of the Higgs signal yields. We also consider fits of p T spectra in models with heavy-top partners and in MSSM scenarios with a light scalar top and study the validity of the SMEFT assumptions as a function of the new-particle masses and the Higgs p T range. Finally, we extract constraints on the Wilson coefficients for gluon fusion from a simultaneous fit to the ATLAS and CMS data and compare our results with those obtained in global SMEFT analyses.

Published
2021
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14. Beyond the Wall. Renaissance Embodiments of the Old Norse god Freyr

Author

Marco Battaglia

Subjects
Adam of Bremen, Norse mythology, Freyr, Gothicism, Swedish Renaissance, Geography. Anthropology. Recreation, Language. Linguistic theory. Comparative grammar, P101-410, Translating and interpreting, P306-310
Abstract

In his Gespräch über die Poesie («Athenäum», III, 1800), Fr. Schlegel reworked some of the ideas put forward years earlier by J. G. Herder – in his controversy with J. Winckelmann – on the need to recover the mythopoietic dimension in national artistic creation and to get rid of the influence of the Greek model, which has been active in German thought for a long time. Schlegel’s work became the manifesto of an upcoming pre-Romantic aesthetic, which for at least two centuries had been rediscovering the memorial heritage of old Germanic mythology, best embodied in the XIIth and XIIIth cent. Old Norse literacy. Among the controversial sources conveying that tradition, works like the early Gesta Hammaburgensis Ecclesiae Pontificum by Adam of Bremen (ca. 1070) and some historical annals of late medieval Sweden generated unprecedented and long-lasting representations of divine simulacra, which were able to influence, both politically and ideologically, the Gothicist movement during the Renaissance. This essay focuses on the representation of Old Norse divine triads during the XVIth-and XVIIth centuries, and specifically on the reception of fertility myths connected with the god Freyr.

Published
2022
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15. CARIBOU‐1: A pilot controlled trial of an Integrated Care Pathway for the treatment of depression in adolescents

Author

Darren B. Courtney, Amy Cheung, Joanna Henderson, Kathryn Bennett, Wei Wang, Sheng Chen, Marco Battaglia, John Strauss, Rachel Mitchell, Karen Wang, Jacqueline Relihan, Matthew Prebeg, Karleigh Darnay, and Peter Szatmari

Subjects
adolescent, care pathway, depression, pilot controlled trial, Pediatrics, RJ1-570, Psychiatry, RC435-571
Abstract

Abstract Background To co‐ordinate a multidisciplinary team in the delivery of guideline recommendations using a measurement‐based care framework, our group previously developed a care pathway for the treatment of depression in adolescents. Core components of the pathway were: assessment, education, cognitive‐behavioural therapy, a caregiver intervention group, a medication algorithm, and monthly measurement‐based care “team reviews” with the adolescent present. The aim of this study was to test the feasibility of conducting a controlled clinical trial of the pathway. Method We conducted a 20‐week pilot controlled clinical trial of the care pathway relative to treatment as usual. Participants were adolescents (age 14–18) with a primary diagnosis of Major Depressive Disorder recruited from one of two outpatient psychiatric clinics at academic hospitals. Site of presentation was the method of allocation. Thirty‐five youth were allocated to the pathway and 31 were allocated to treatment as usual. As this is a pilot study, trial feasibility outcomes were of primary interest, including clinician fidelity to the care pathway. Results Our target sample size was recruited over a 15‐month time interval. Clinician fidelity and adolescent engagement in the care pathway components on a priori checklists were high (95% and 80%, respectively). We collected baseline and 20‐week endpoint data for our primary outcome of the Children's Depression Rating Scale – Revised (CDRS‐R) for 83% of the sample. On linear mixed effects modelling, we observed a linear decrease in CDRS‐R across 4‐week intervals up to the 20‐week endpoint in both groups (β = −2.07; 95% CI −3.14 to −1.01). Conclusion A controlled clinical trial of a complex, multi‐component intervention for the treatment of depression in adolescents is feasible. Given the need to find optimal strategies to deliver effective care for adolescents with depression, a definitive randomized controlled trial of the pathway is warranted. Trial is registered at Clinicaltrials.gov: NCT03428555

Published
2022
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16. COVID-19 Pandemic Impact and Response in Canadian Pediatric Chronic Pain Care: A National Survey of Medical Directors and Pain Professionals

Author

Tieghan Killackey, Melanie Noel, Kathryn A. Birnie, Manon Choinière, M. Gabrielle Pagé, Lise Dassieu, Anaïs Lacasse, Chitra Lalloo, Sarah Brennenstuhl, Patricia Poulin, Pablo Ingelmo, Samina Ali, Marco Battaglia, Fiona Campbell, Andrew Smith, Lauren Harris, Vina Mohabir, Myles Benayon, Isabel Jordan, Justina Marianayagam, and Jennifer Stinson

Subjects
covid-19, pediatric pain, pain clinics, distance treatments, e-health, telehealth, Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950
Abstract

Background: The COVID-19 pandemic presents one of the greatest threats to pediatric pain care seen in generations. Due to public health restrictions, many pediatric pain clinics halted in-person appointments, delaying and disrupting access to care. There is no existing research on the impacts of COVID-19 on pediatric chronic pain care in Canada or the challenges experienced by health care professionals and pain clinics. Aims: The aim of this study was to evaluate the impact of COVID-19 on Canadian pediatric chronic pain care by documenting how health care professionals provided care during the first six months of the pandemic. Methods: Two Canadian online cross-sectional surveys were conducted: one among Canadian pediatric pain clinic directors (Study 1) and another among multidisciplinary pediatric pain health care professionals (Study 2). Results: Responses from 13/13 Canadian pediatric pain clinics/rehabilitation programs indicated that all clinics provided virtual care during the pandemic. No significant changes were reported on the frequency of appointment requests. Most clinics reported no perceived change in patient pain levels (n = 9/13, 69%) or occurrence of pain flares (n = 10/13, 77%). Results from 151 individual health care professionals indicated that the majority (90%) of non–emergency department respondents were providing virtual care. The main challenges of virtual care included technological barriers, financial concerns, infrastructure and logistics, privacy, and clinical challenges. Conclusions: This study documented the impact of the COVID-19 pandemic on pediatric chronic pain care in Canada and highlighted the rapid shift to using virtual solutions. Simultaneously, respondents outlined current challenges and potential solutions to consider in the development of virtual care guidelines and policy in Canada.

Published
2021
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17. Balance Rehabilitation through Robot-Assisted Gait Training in Post-Stroke Patients: A Systematic Review and Meta-Analysis

Author

Alberto Loro, Margherita Beatrice Borg, Marco Battaglia, Angelo Paolo Amico, Roberto Antenucci, Paolo Benanti, Michele Bertoni, Luciano Bissolotti, Paolo Boldrini, Donatella Bonaiuti, Thomas Bowman, Marianna Capecci, Enrico Castelli, Loredana Cavalli, Nicoletta Cinone, Lucia Cosenza, Rita Di Censo, Giuseppina Di Stefano, Francesco Draicchio, Vincenzo Falabella, Mirko Filippetti, Silvia Galeri, Francesca Gimigliano, Mauro Grigioni, Marco Invernizzi, Johanna Jonsdottir, Carmelo Lentino, Perla Massai, Stefano Mazzoleni, Stefano Mazzon, Franco Molteni, Sandra Morelli, Giovanni Morone, Antonio Nardone, Daniele Panzeri, Maurizio Petrarca, Federico Posteraro, Andrea Santamato, Lorenza Scotti, Michele Senatore, Stefania Spina, Elisa Taglione, Giuseppe Turchetti, Valentina Varalta, Alessandro Picelli, and Alessio Baricich

Subjects
rehabilitation, robotics, balance, stroke, gait, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Background: Balance impairment is a common disability in post-stroke survivors, leading to reduced mobility and increased fall risk. Robotic gait training (RAGT) is largely used, along with traditional training. There is, however, no strong evidence about RAGT superiority, especially on balance. This study aims to determine RAGT efficacy on balance of post-stroke survivors. Methods: PubMed, Cochrane Library, and PeDRO databases were investigated. Randomized clinical trials evaluating RAGT efficacy on post-stroke survivor balance with Berg Balance Scale (BBS) or Timed Up and Go test (TUG) were searched. Meta-regression analyses were performed, considering weekly sessions, single-session duration, and robotic device used. Results: A total of 18 trials have been included. BBS pre-post treatment mean difference is higher in RAGT-treated patients, with a pMD of 2.17 (95% CI 0.79; 3.55). TUG pre-post mean difference is in favor of RAGT, but not statistically, with a pMD of −0.62 (95%CI − 3.66; 2.43). Meta-regression analyses showed no relevant association, except for TUG and treatment duration (β = −1.019, 95% CI − 1.827; −0.210, p-value = 0.0135). Conclusions: RAGT efficacy is equal to traditional therapy, while the combination of the two seems to lead to better outcomes than each individually performed. Robot-assisted balance training should be the focus of experimentation in the following years, given the great results in the first available trials. Given the massive heterogeneity of included patients, trials with more strict inclusion criteria (especially time from stroke) must be performed to finally define if and when RAGT is superior to traditional therapy.

Published
2023
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18. Reasons and Determinants of BoNT-A Treatment Discontinuation in Patients Living with Spasticity: A 10-Year Retrospective Analysis

Author

Nicoletta Cinone, Luigi Santoro, Stefania Spina, Salvatore Facciorusso, Marco Battaglia, Alessio Baricich, Pasqua Marcogiuseppe, and Andrea Santamato

Subjects
botulinum toxin, spasticity, discontinuation, Medicine
Abstract

Background: The present study aimed to evaluate the reasons and determinants of BoNT-A discontinuation in patients with stroke, multiple sclerosis, spinal cord injury, and traumatic brain injury. Methods: It is a retrospective study of 56 discontinuer patients treated with botulinum toxin between January 2011 and December 2021. Discontinuation rates and their predictors were estimated using Kaplan–Meier, Log rank test, and Cox’s regression method of analyses. Results: The mean age was 56.54 years, 53.57% were affected by post-stroke spasticity, 17.86% by spinal cord injury, 12.5% and 16.07% by traumatic brain injury and multiple sclerosis, respectively. The median discontinuation time was 5 months. The main reason for discontinuation were logistic problems (37%) and orthopedic surgeries or intrathecal baclofen (27%). Discontinuers were more likely to have severe spasticity (R = 1.785), have no pain (HR = 1.320), no access to rehabilitation services (HR = 1.402), and have cognitive impairment (HR = 1.403). Conclusions: The main reasons for discontinuation are related to logistic issues (due to distance or the absence of an adequate caregiver) and surgical interventions for spasticity, including intrathecal baclofen. It is crucial to identify possible predictors of discontinuation to improve the effectiveness of a multidisciplinary management. The study confirms the crucial role of rehabilitation and caregivers in achieving better long-term outcomes.

Published
2022
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19. Mid-term Psychiatric Outcomes of Patients Recovered From COVID-19 From an Italian Cohort of Hospitalized Patients

Author

Carla Gramaglia, Eleonora Gambaro, Mattia Bellan, Piero Emilio Balbo, Alessio Baricich, Pier Paolo Sainaghi, Mario Pirisi, Giulia Baldon, Sofia Battistini, Valeria Binda, Alessandro Feggi, Martina Gai, Eleonora Gattoni, Amalia Jona, Luca Lorenzini, Debora Marangon, Maria Martelli, Pierluigi Prosperini, Patrizia Zeppegno, The NO-MORE COVID Group, Gian Carlo Avanzi, Marco Battaglia, Emanuela Cadario, Vincenzo Cantaluppi, Luigi Mario Castello, Elisa Clivati, Martina Costanzo, Alessandro Croce, Carla De Benedittis, Simona De Vecchi, Francesco Gavelli, Leonardo Grisafi, Eyal Hayden, Marco Invernizzi, Paolo Marzullo, Erica Matino, Antonio Panero, Elena Parachini, Filippo Patrucco, Giuseppe Patti, Alice Pirovano, Cristina Rigamonti, Daniele Soddu, and Erika Zecca

Subjects
COVID-19, anxiety, depression, patients, follow-up, mid-term sequelae, Psychiatry, RC435-571
Abstract

Background: Although the usual primary clinical manifestation of Coronavirus disease (COVID-19) is respiratory, several non-respiratory symptoms have been described, including neuropsychiatric ones. The aim of this study was to investigate the mid-term mental health outcomes in patients recovered from COVID-19, 3–4 months after discharge from the University Hospital Maggiore della Carità, Novara, Italy. Furthermore, we investigated the possible association of the mid-term mental health consequences of the COVID-19 infection with patients' clinical current status, persistent physical impairment and severity of acute phase of the disease.Methods: Prospective study involving 238 individuals recovered from COVID-19. In the context of a multi-disciplinary approach, patients' assessment included both a clinical interview performed by an experienced psychiatrist, trained in the use of the Mini-International Neuropsychiatric Interview to assess the presence of anxiety and depressive symptoms and self-administered questionnaires: Beck Anxiety Inventory (BAI), Beck Depression Inventory-II (BDI-II), Resilience Scale for Adults (RSA), Impact of Event Scale (IES).Results: At the psychiatric assessment 32.9 and 29.5% of participants showed anxiety and depressive symptoms, respectively. Changes in appetite and sleep patterns emerged for 15.6 and 31.2% of patients. According to the self-administered questionnaires, 7.1% of participants had moderate-severe anxiety levels (BAI), while 10.5% had mild to severe depression (BDI-II). Twenty-six (11%) participants were referred to further psychiatric consultation. Psychiatric symptoms showed no correlation with acute COVID-19 severity; in our sample patients with depressive symptoms at the clinical interview, as well as those with mild to severe levels of depression according to BDI-II scores, had lower forced expiratory volume in the 1st second (FEV1) values than those without and greater odds for persistent, poor tolerance for physical efforts.Conclusions: As could be expected, an approach including both a psychiatric interview and the use of self-administered questionnaires is likely to capture the psychiatric outcome of patients recovered from COVID-19 better than questionnaires alone. Anxiety and depressive symptoms at follow-up had no correlation with the severity of COVID acute manifestations, but rather with ongoing and persistent physical symptoms. Further studies and longer follow-up duration will allow a better understanding of the complex relationship between residual physical symptoms, quality of life and psychological health.

Published
2021
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20. The Lack of Systemic and Subclinical Side Effects of Botulinum Neurotoxin Type-A in Patients Affected by Post-Stroke Spasticity: A Longitudinal Cohort Study

Author

Marco Battaglia, Margherita Beatrice Borg, Lara Torgano, Alberto Loro, Lucia Cosenza, Michele Bertoni, Alessandro Picelli, Andrea Santamato, Marco Invernizzi, Francesca Uberti, Claudio Molinari, Stefano Carda, and Alessio Baricich

Subjects
muscle spasticity, botulinum toxin, heart rate, stroke, autonomic nervous system, rehabilitation, Medicine
Abstract

Botulinum Neurotoxin type-A (BoNT-A) is the treatment of choice for focal post-stroke spasticity (PSS). Due to its mechanism of action and the administration method, some authors raised concern about its possible systemic diffusion leading to contralateral muscle weakness and autonomic nervous system (ANS) alterations. Stroke itself is a cause of motor disability and ANS impairment; therefore, it is mandatory to prevent any source of additional loss of strength and adjunctive ANS disturbance. We enrolled 15 hemiparetic stroke survivors affected by PSS already addressed to BoNT-A treatment. Contralateral handgrip strength and ANS parameters, such as heart rate variability, impedance cardiography values, and respiratory sinus arrythmia, were measured 24 h before (T0) and 10 days after (T1) the ultrasound (US)-guided BoNT-A injection. At T1, neither strength loss nor modification of the basal ANS patterns were found. These findings support recent literature about the safety profile of BoNT-A, endorsing the importance of the US guide for a precise targeting and the sparing of “critical” structures as vessels and nerves.

Published
2022
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21. Stability of extemporaneously compounded amiloride nasal spray.

Author

Venkata Yellepeddi, Casey Sayre, Anna Burrows, Kevin Watt, Simon Davies, John Strauss, and Marco Battaglia

Subjects
Medicine, Science
Abstract

Anxiety disorders (AD) are the most common mental conditions affecting an estimated 40 million adults in the United States. Amiloride, a diuretic agent, has shown efficacy in reducing anxious responses in preclinical models by inhibiting the acid-sensing ion channels (ASIC). By delivering amiloride via nasal route, rapid onset of action can be achieved due to direct "nose-to-brain" access. Therefore, this study reports the formulation, physical, chemical, and microbiological stability of an extemporaneously prepared amiloride 2 mg/mL nasal spray. The amiloride nasal spray was prepared by adding 100 mg of amiloride hydrochloride to 50 mL of sterile water for injection in a sterile reagent bottle. A stability-indicating high-performance liquid chromatography (HPLC) method was developed and validated. Forced-degradation studies were performed to confirm the ability of the HPLC method to identify the degradation products from amiloride distinctively. The physical stability of the amiloride nasal spray was assessed by pH, clarity, and viscosity assessments. For chemical stability studies, samples of nasal sprays stored at room temperature were collected at time-points 0, 3 hr., 24 hr., and 7 days and were assayed in triplicate using the stability-indicating HPLC method. Microbiological stability of the nasal spray solution was evaluated for up to 7 days based on the sterility test outlined in United States Pharmacopoeia (USP) chapter 71. The stability-indicating HPLC method identified the degradation products of amiloride without interference from amiloride. All tested solutions retained over 90% of the initial amiloride concentration for the 7-day study period. There were no changes in color, pH, and viscosity in any sample. The nasal spray solutions were sterile for up to 7 days in all samples tested. An extemporaneously prepared nasal spray solution of amiloride hydrochloride (2 mg/mL) was physically, chemically, and microbiologically stable for 7 days when stored at room temperature.

Published
2020
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22. Experiences of Pediatric Pain Professionals Providing Care during the COVID-19 Pandemic: A Qualitative Study

Author

Tieghan Killackey, Krista Baerg, Bruce Dick, Christine Lamontagne, Raju Poolacherla, G. Allen Finley, Melanie Noel, Kathryn A. Birnie, Manon Choinière, M. Gabrielle Pagé, Lise Dassieu, Anaïs Lacasse, Chitra Lalloo, Patricia Poulin, Samina Ali, Marco Battaglia, Fiona Campbell, Lauren Harris, Vina Mohabir, Fareha Nishat, Myles Benayon, Isabel Jordan, and Jennifer Stinson

Subjects
COVID-19, pediatric pain, pain clinics, distance treatments, e-health, telehealth, Pediatrics, RJ1-570
Abstract

Chronic pain affects 1 in 5 youth, many of whom manage their pain using a biopsychosocial approach. The COVID-19 pandemic has impacted the way that healthcare is delivered. As part of a larger program of research, this study aimed to understand the impact of the pandemic on pediatric chronic pain care delivery including impact on patients’ outcomes, from the perspective of pediatric healthcare providers. A qualitative descriptive study design was used and 21 healthcare providers from various professional roles, clinical settings, and geographic locations across Canada were interviewed. Using a reflexive thematic analysis approach 3 themes were developed: (1) duality of pandemic impact on youth with chronic pain (i.e., how the pandemic influenced self-management while also exacerbating existing socioeconomic inequalities); (2) changes to the healthcare system and clinical practices (i.e., triaging and access to care); (3) shift to virtual care (i.e., role of institutions and hybrid models of care). These findings outline provider perspectives on the positive and negative impacts of the pandemic on youth with chronic pain and highlight the role of socioeconomic status and access to care in relation to chronic pain management during the pandemic in a high-income country with a publicly funded healthcare system.

Published
2022
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23. Triceps Surae Muscle Characteristics in Spastic Hemiparetic Stroke Survivors Treated with Botulinum Toxin Type A: Clinical Implications from Ultrasonographic Evaluation

Author

Marco Battaglia, Lucia Cosenza, Lorenza Scotti, Michele Bertoni, Marco Polverelli, Alberto Loro, Andrea Santamato, and Alessio Baricich

Subjects
muscle spasticity, spastic equinovarus foot, botulinum toxin, diagnostic imaging, ultrasonography, diagnostic techniques, Medicine
Abstract

Equinovarus foot is one of the most commonly spasticity related conditions in stroke survivors, leading to an impaired gait and poor functional performances. Notably, spastic muscles undergo a dynamic evolution following typical pathophysiological patterns. Botulinum Neurotoxin Type A (BoNT-A) is the gold standard for focal spasticity treatment, and ultrasound (US) imaging is widely recommended to guide injections and monitor muscle evolution. The role of BoNT-A in influencing muscle fibroadipose degeneration is still unclear. In this study, we analyzed medial gastrocnemius (MG) and soleus (SOL) US characteristics (cross-sectional area, muscle thickness, pennation angle, and mean echo intensity) in 53 patients. MG and SOL alterations, compared to the unaffected side, depend on the spasticity only and not on the BoNT-A treatment. In functionally preserved patients (functional ambulation classification, FAC > 3; modified Ashworth scale, MAS ≤ 2), the ultrasonographic changes of MG compared to ipsilateral SOL observed in the paretic limb alone seems to be due to histological, anatomical, pathophysiological, and biomechanical differences between the two muscles. In subjects with poor walking capability and more severe spasticity, such ipsilateral difference was found in both calves. In conclusion, BoNT-A does not seem to influence muscle degeneration. Similar muscles undergo different evolution depending on the grade of walking deficit and spasticity.

Published
2021
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24. Repeated Cross-fostering Protocol as a Mouse Model of Early Environmental Instability

Author

Alessandra Luchetti, Marco Battaglia, and Francesca D’Amato

Subjects
Biology (General), QH301-705.5
Abstract

Early life events have a crucial role in programming the individual phenotype indeed the exposure to traumatic experiences during infancy can increase later risks for a variety of neuropsychiatric conditions, including mood and anxiety disorders. Several studies in rodents demonstrated the impact of short and long sessions of separation/isolation from caregivers in developing pups, on the behavioral and hormonal response to stress during infancy and adulthood (D’Amato et al., 1998; Meaney et al., 2000; Luchetti et al., 2015). The repeated cross-fostering (RCF) is an early manipulation carried out in mouse pups during the first four postnatal days life. Differently from other early manipulations, hypotalamic-pituitary-adrenal (HPA) axis functioning is not altered in RCF treated subjects. This manipulation is used to model human early environmental instability, a risk factor for internalizing disorders including separation anxiety disorder, panic disorder and CO2 hypersensitivity (Kendler et al., 1992; Forman and Davies, 2003; Battaglia et al., 2009).

Published
2016
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26. Iodine carry over in dairy cows: effects of levels of diet fortification and milk yield

Author

Francesco Masoero, Gianfranco Piva, Antonio Gallo, Maurizio Moschini, Gianluca Giuberti, and Marco Battaglia

Subjects
Iodine, Milk, Carry over., Animal culture, SF1-1100
Abstract

Thirty multiparous lactating cows were divided in three groups based on milk yield: high (H), average (A) and low (L). Within each group, cows were randomly allotted to two levels of iodine inclusions into the diet and respectively: level 1 (1): base diet containing 1.55 mg/kg dry matter, level 2 (2): base diet plus 47.2 mg/d. Potassium iodide was used. Feeds, orts, drinking water and individual milk samples were collected and analysed for the iodine content. The iodine concentration and total excretion in milk were affected by the level of iodine supplementation (P

Published
2010
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27. Effect of the presence of two commercial adsorbents in animal feed on Aflatoxin B1 determination by ELISA kit test

Author

Francesco Masoero, Marta Vilas Boas, Marco Battaglia, Maurizio Moschini, and Antonio Gallo

Subjects
Aflatoxins, Adsorbents, ELISA, feedstuffs, Animal culture, SF1-1100
Abstract

A rapid AFB1 detection method by ELISA kit test was used on feedstuff samples, and compared to an HPLC method, to verify if the presence of clay-adsorbent (SA) could cause erroneous quantification of the toxin. Samples were obtained using two AFB1-contaminated feedstuffs (7.92 and 17.58 µg/kg for low and high contaminated feeds; LC and HC respectively), added either one of two commercial SAs (Atox® and Myco AD) and three different inclusion doses (0, 10 and 20 g/kg, respectively for CTR, 1% and 2% doses). The HPLC and ELISA data were compared in CTR samples with a paired t-test. The AFB1 recoveries, performed with ELISA, were analysed as a completely randomized design using a 2×2×3 factorial arrangement. The ELISA method tended to underestimate the AFB1 concentrations with respect to the HPLC method, both in HC (P=0.050) and in LC (P

Published
2010
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28. Unstable maternal environment, separation anxiety, and heightened CO2 sensitivity induced by gene-by-environment interplay.

Author

Francesca R D'Amato, Claudio Zanettini, Valentina Lampis, Roberto Coccurello, Tiziana Pascucci, Rossella Ventura, Stefano Puglisi-Allegra, Chiara A M Spatola, Paola Pesenti-Gritti, Diego Oddi, Anna Moles, and Marco Battaglia

Subjects
Medicine, Science
Abstract

In man, many different events implying childhood separation from caregivers/unstable parental environment are associated with heightened risk for panic disorder in adulthood. Twin data show that the occurrence of such events in childhood contributes to explaining the covariation between separation anxiety disorder, panic, and the related psychobiological trait of CO(2) hypersensitivity. We hypothesized that early interference with infant-mother interaction could moderate the interspecific trait of response to CO(2) through genetic control of sensitivity to the environment.Having spent the first 24 hours after birth with their biological mother, outbred NMRI mice were cross-fostered to adoptive mothers for the following 4 post-natal days. They were successively compared to normally-reared individuals for: number of ultrasonic vocalizations during isolation, respiratory physiology responses to normal air (20%O(2)), CO(2)-enriched air (6% CO(2)), hypoxic air (10%O(2)), and avoidance of CO(2)-enriched environments.Cross-fostered pups showed significantly more ultrasonic vocalizations, more pronounced hyperventilatory responses (larger tidal volume and minute volume increments) to CO(2)-enriched air and heightened aversion towards CO(2)-enriched environments, than normally-reared individuals. Enhanced tidal volume increment response to 6%CO(2) was present at 16-20, and 75-90 postnatal days, implying the trait's stability. Quantitative genetic analyses of unrelated individuals, sibs and half-sibs, showed that the genetic variance for tidal volume increment during 6%CO(2) breathing was significantly higher (Bartlett χ = 8.3, p = 0.004) among the cross-fostered than the normally-reared individuals, yielding heritability of 0.37 and 0.21 respectively. These results support a stress-diathesis model whereby the genetic influences underlying the response to 6%CO(2) increase their contribution in the presence of an environmental adversity. Maternal grooming/licking behaviour, and corticosterone basal levels were similar among cross-fostered and normally-reared individuals.A mechanism of gene-by-environment interplay connects this form of early perturbation of infant-mother interaction, heightened CO(2) sensitivity and anxiety. Some non-inferential physiological measurements can enhance animal models of human neurodevelopmental anxiety disorders.

Published
2011
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29. Young offspring at genetic risk of adult psychoses: the form of the trajectory of IQ or memory may orient to the right dysfunction at the right time.

Author

Michel Maziade, Nancie Rouleau, Caroline Cellard, Marco Battaglia, Thomas Paccalet, Isabel Moreau, Valérie Gagnon, Nathalie Gingras, Cecilia Marino, Elsa Gilbert, Marc-André Roy, and Chantal Mérette

Subjects
Medicine, Science
Abstract

Neurocognitive dysfunctions analogous to those of adult patients have been detected in children at risk of schizophrenia and bipolar disorder. This led to the following developmental question: Do IQ and memory impairments exhibit different developmental courses from childhood to young adulthood in terms of stability or fluctuations?In a high risk sample, we used a step by step sampling approach to narrow-down the early disease mechanisms. Upstream, we started with a 20-year follow-up of 48 densely affected multigenerational kindreds, including 1500 clinically characterized adult members. We then identified 400 adult members affected by a DSM-IV schizophrenia or bipolar disorder. Downstream, we finally focused on 65 offspring (of an affected parent) aged 7 to 22, who were administered a neuropsychological battery. We then constructed cross-sectional trajectories that were compared to those of controls.The childhood IQ deficit displayed a stability until young adulthood. The delay in visual memory exhibited a non-linear two-stage trajectory: a lagging period during childhood followed by a recuperation period from adolescence until adulthood, as supported by a significant Group x Age Periods interaction. No data suggested deterioration between 7 and 22.In these offspring at genetic risk, the developmental trajectory of global IQ impairment may not apply to specific domains of cognition such as episodic memory. Different cognitive dysfunctions would mark different developmental courses. The shape of the trajectories might itself have a meaning and provide empirical leads for targeting the right dysfunction at the right time in future prevention research.

Published
2011
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30. We need to talk: The urgent conversation on chronic pain, mental health, prescribing patterns and the opioid crisis

Author

Marco Battaglia, Cornelius B Groenewald, Fiona Campbell, Simona Scaini, Yves De Koninck, Jennifer Stinson, and Patrick D Quinn

Subjects
Pharmacology, Psychiatry and Mental health, Pharmacology (medical)
Abstract

The opioid crisis’ pathways from first exposure onwards to eventual illnesses and fatalities are multiple, intertwined and difficult to dissect. Here, we offer a multidisciplinary appraisal of the relationships among mental health, chronic pain, prescribing patterns worldwide and the opioid crisis. Because the opioid crisis’ toll is especially harsh on young people, emphasis is given on data regarding the younger strata of the population. Because analgesic opioid prescription constitute a recognised entry point towards misuse, opioid use disorder, and ultimately overdose, prescribing patterns across different countries are examined as a modifiable hazard factor along these pathways of risk. Psychiatrists are called to play a more compelling role in this urgent conversation, as they are uniquely placed to provide synthesis and lead action among the different fields of knowledge and care that lie at the crossroads of the opioid crisis. Psychiatrists are also ideally positioned to gauge and disseminate the foundations for diagnosis and clinical management of mental conditions associated with chronic pain, including the identification of hazardous and protective factors. It is our hope to spark more interdisciplinary exchanges and encourage psychiatrists worldwide to become leaders in an urgent conversation with interlocutors from the clinical and basic sciences, policy makers and stakeholders including clients and their families.

Published
2023

31. Mediating effect of genome-wide DNA methylation on suicidal ideation induced by stressful events

Author

Vincenzo, De Luca, Nzaar, Al-Chalabi, Zanib, Chaudhary, Jessica, Qian, Carol, Borlido, Araba, Chintoh, Philip, Gerretsen, Ariel, Graff, Gary, Remington, Marcos, Sanches, and Marco, Battaglia

Subjects
Psychiatry and Mental health, Genetics, Biological Psychiatry, Genetics (clinical)
Abstract

Schizophrenia is a debilitating disease that is associated with higher rates of death by unnatural causes including suicide. Exposure to stressful events is an important risk factor for suicidal ideation (SI); however, the mechanisms that link stress, SI, and suicide remain unclear. Epigenetic processes are involved in both vulnerability to suicidal behavior and stress. Therefore, we sought to study the relationship between epigenetic modifications and suicidal behavior and stress.This pilot study was conducted on 39 patients diagnosed with schizophrenia (54% men and age 45.5 ± 12.7). We analyzed the effects of (a) stress exposure and (b) the mediation of DNA methylation [via an epigenetic wide association study (EWAS) of more than 450 000 CpG sites across the genome] on SI severity.The top CpG site mediating the effect of global stress exposure on SI was cg27660192 located in an intergenic region on chromosome 11, exerting a facilitating effect on worsening SI through DNA hypomethylation.These preliminary results indicate that DNA methylation in peripheral tissues can shed light on the complex relationship between stress and SI in schizophrenia.

Published
2022

32. Novel intranasal treatment for anxiety disorders using amiloride, an acid-sensing ion channel antagonist: Pharmacokinetic modeling and simulation

Author

Mahmoud Azzeh, Marco Battaglia, Simon Davies, John Strauss, Prashant Dogra, and Venkata Yellepeddi

Subjects
Acid Sensing Ion Channels, Amiloride, Pharmacology, Acid Sensing Ion Channel Blockers, Administration, Oral, Humans, Computer Simulation, Pharmacology (medical), Anxiety Disorders, Models, Biological, Administration, Intranasal
Abstract

To develop a physiologically based pharmacokinetic (PBPK) model for amiloride, an acid-sensing ion channel (ASIC) antagonist, and to simulate its pharmacokinetics in plasma and the central nervous system following intranasal administration in a virtual human population.We first developed a PBPK model of amiloride after oral administration and optimized the model using data from five clinical studies. Next, we added a nasal compartment to the amiloride oral PBPK model and parameterized using data from previous clinical studies. We simulated amiloride's pharmacokinetics in plasma, brain, and cerebrospinal fluid (CSF) after intranasal administration of amiloride at various doses in a virtual human population.The target amiloride concentration in the central nervous system required for maximal ASIC inhibition was achieved with a 75-mg intranasal amiloride dose. However, this finding is based on simulations performed using a mathematical model and needs to be further validated with appropriate clinical data.The nasal PBPK model of amiloride could be used to design future clinical studies and allow for successful clinical translation of intranasal amiloride formulation.

Published
2022

34. Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19

Author

Gian Carlo Avanzi, Michela Barini, Piero Emilio Balbo, Simone Bor, Carla Gramaglia, Pier Paolo Sainaghi, Alberto Loro, Giuseppe Patti, Alessio Baricich, Alessandro Carriero, Mario Pirisi, Mattia Bellan, Davide Raineri, Francesco Murano, Filippo Patrucco, Patrizia Zeppegno, Marco Battaglia, Umberto Morosini, Annalisa Chiocchetti, Federico Ceruti, Stefano Tricca, Daria Cuneo, E. Gattoni, Roberta Rolla, Chiara Santa Amico, Elena Paracchini, Eleonora Gambaro, Mara Giordano, Giuseppe Cappellano, Elisa Clivati, David J. Pinato, Vincenzo Cantaluppi, and Marcello Manfredi

Subjects
Male, Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Science, Walk Test, Motor Activity, Microbiology, Article, Pulmonary function testing, Stress Disorders, Post-Traumatic, Post-Acute COVID-19 Syndrome, DLCO, Virology, medicine, Prevalence, Humans, Respiratory function, Lung volumes, Prospective Studies, Survivors, Prospective cohort study, Aged, Carbon Monoxide, Multidisciplinary, Lung, business.industry, Patient Acuity, COVID-19, Middle Aged, medicine.disease, Patient Discharge, Respiratory Function Tests, Hospitalization, Pneumonia, medicine.anatomical_structure, Logistic Models, Mental Health, Italy, Pulmonary Diffusing Capacity, Medicine, Female, business, Tomography, X-Ray Computed
Abstract

Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363–369] days, 79 patients (39.5%) reported at least one symptom. A DLCO

Published
2021

36. Individual- and Family-Level Associations between Child Psychopathology and Parenting

Author

Madison Aitken, Florence Perquier, John D. Haltigan, Li Wang, Brendan F. Andrade, Marco Battaglia, Peter Szatmari, and Katholiki Georgiades

Subjects
Psychiatry and Mental health, Developmental and Educational Psychology
Abstract

Parenting can protect against the development of, or increase risk for, child psychopathology; however, it is unclear if parenting is related to psychopathology symptoms in a specific domain, or to broad liability for psychopathology. Parenting differs between and within families, and both overall family-level parenting and the child-specific parenting a child receives may be important in estimating transdiagnostic associations with psychopathology. Data come from a cross-sectional epidemiological sample (N = 10,605 children ages 4–17, 6434 households). Parents rated child internalizing and externalizing symptoms and their parenting toward each child. General and specific (internalizing, externalizing) psychopathology factors, derived with bifactor modeling, were regressed on parenting using multilevel modeling. Less warmth and more aversive/inconsistent parenting in the family, and toward an individual child relative to family average, were associated with higher general psychopathology and specific externalizing problems. Unexpectedly, more warmth in the family, and toward an individual child relative to family average, was associated with higher specific internalizing problems in 4–11 (not 12–17) year-olds. Less warmth and more aversive/inconsistent parenting are broad correlates of child psychopathology. Aversive/inconsistent parenting, is also related to specific externalizing problems. Parents may behave more warmly when their younger children have specific internalizing problems, net of overall psychopathology.

Published
2022

37. Adolescent pain, anxiety, and depressive problems: a twin study of their co-occurrence and the relationship to substance use

Author

Marco Battaglia, Corrado Fagnani, Giorgia Michelini, Maria Antonietta Stazi, Emanuela Medda, Simona Scaini, Stefano De Francesco, Scaini, S, Michelini, G, De Francesco, S, Fagnani, C, Medda, E, Stazi, M, and Battaglia, M

Subjects
Schmidt sting pain index, Adolescent, Substance-Related Disorders, Diseases in Twins, Twins, Dizygotic, Humans, Medicine, pain, twin study, Risk factor, Depression (differential diagnoses), business.industry, Incidence (epidemiology), Twins, Monozygotic, anxiety, Anxiety Disorders, Twin study, Anesthesiology and Pain Medicine, Neurology, Opioid, depression, Etiology, Anxiety, adolescence, Neurology (clinical), medicine.symptom, business, Clinical psychology, medicine.drug
Abstract

Data on the etiological factors underlying the co-occurrence of common adolescent pain with anxiety and depression symptoms are very limited. Opioid prescriptions for adolescent pain problems are on the rise in North America and constitute a risk factor for diversion, misuse, and substance use. In this study, we aimed to investigate the phenotypic and etiological association among pain, depression, and anxiety and to test their link to substance use in adolescents. By taking advantage of the Italian National Twin Registry and of the relatively low incidence of opioid prescriptions in Italy, we applied multivariate modelling analyses to 748 Italian adolescent twins (374 pairs, mean age 16 ± 1.24 years). Twins' responses to the Achenbach Youth Self-Report questionnaire were used to build a composite adolescent pain index and to measure anxiety, depression, and substance use. All monozygotic within-pair correlations were higher than the dizygotic correlations, indicating genetic influences for adolescent pain, anxiety, and depressive problems. A common latent liability factor influenced by genetic and environmental elements shared among pain, depression, and anxiety provided the best fit to explain the co-occurrence of adolescent pain, anxiety, and depression problems. A common phenotypic factor capturing all 3 phenotypes was positively associated (β = 0.19, P < 0.001, confidence interval: 0.10-0.27) with substance use. These findings indicate that several intertwined mechanisms, including genetic factors, can explain a shared liability to common adolescent pain, anxiety, and depression problems. Their association with substance use remains traceable even in societies with relatively low prevalence of opioid prescriptions.

Published
2021

38. COVID-19 Pandemic Impact and Response in Canadian Pediatric Chronic Pain Care: A National Survey of Medical Directors and Pain Professionals

Author

Lauren Harris, Jennifer Stinson, Pablo Ingelmo, Chitra Lalloo, Andrew M. Smith, Anaïs Lacasse, Patricia A. Poulin, Lise Dassieu, Justina Marianayagam, Manon Choinière, Sarah Brennenstuhl, Samina Ali, Fiona Campbell, Marco Battaglia, Vina Mohabir, M. Gabrielle Pagé, Isabel Jordan, Melanie Noel, Tieghan Killackey, Kathryn A. Birnie, and Myles Benayon

Subjects
medicine.medical_specialty, 2019-20 coronavirus outbreak, Medicine (General), Coronavirus disease 2019 (COVID-19), telehealth, Telehealth, RM1-950, pediatric pain, 03 medical and health sciences, 0302 clinical medicine, R5-920, Pandemic, Medicine, 030212 general & internal medicine, business.industry, pain clinics, Public health, Chronic pain, COVID-19, medicine.disease, 3. Good health, Anesthesiology and Pain Medicine, Pain Clinics, Family medicine, Pediatric pain, distance treatments, e-health, Therapeutics. Pharmacology, business, 030217 neurology & neurosurgery, Research Article
Abstract

Background: The COVID-19 pandemic presents one of the greatest threats to pediatric pain care seen in generations. Due to public health restrictions, many pediatric pain clinics halted in-person appointments, delaying and disrupting access to care. There is no existing research on the impacts of COVID-19 on pediatric chronic pain care in Canada or the challenges experienced by health care professionals and pain clinics. Aims: The aim of this study was to evaluate the impact of COVID-19 on Canadian pediatric chronic pain care by documenting how health care professionals provided care during the first six months of the pandemic. Methods: Two Canadian online cross-sectional surveys were conducted: one among Canadian pediatric pain clinic directors (Study 1) and another among multidisciplinary pediatric pain health care professionals (Study 2). Results: Responses from 13/13 Canadian pediatric pain clinics/rehabilitation programs indicated that all clinics provided virtual care during the pandemic. No significant changes were reported on the frequency of appointment requests. Most clinics reported no perceived change in patient pain levels (n = 9/13, 69%) or occurrence of pain flares (n = 10/13, 77%). Results from 151 individual health care professionals indicated that the majority (90%) of non–emergency department respondents were providing virtual care. The main challenges of virtual care included technological barriers, financial concerns, infrastructure and logistics, privacy, and clinical challenges. Conclusions: This study documented the impact of the COVID-19 pandemic on pediatric chronic pain care in Canada and highlighted the rapid shift to using virtual solutions. Simultaneously, respondents outlined current challenges and potential solutions to consider in the development of virtual care guidelines and policy in Canada.

Published
2021

39. Monthly correlates of longitudinal child mental health during the COVID-19 pandemic according to children and caregivers

Author

Lance M. Rappaport, Alexandra Mactavish, Carli Mastronardi, Kimberley A. Babb, Rosanne Menna, Ananda B. Amstadter, and Marco Battaglia

Subjects
Psychiatry and Mental health, Pediatrics, Perinatology and Child Health, Developmental and Educational Psychology, General Medicine
Abstract

Background. Multiple reviews identify the broad, pervasive initial impact of the global COVID-19 pandemic on the mental health of children, who may be particularly vulnerable to long-term psychiatric sequelae of the ongoing pandemic. However, limited longitudinal research examines persistence of, or change in, children’s distress or psychiatric symptomatology.Methods. From June 2020 through December 2021, we enrolled two cohorts of families of children aged 8 to 13 from Southwestern Ontario into a staggered baseline, longitudinal design that leveraged multi-informant report (N=317 families). In each family, one child and one parent or guardian completed a baseline assessment, 6 monthly follow-up assessments, and one final follow-up assessment 9 months post-baseline. At each assessment, the child and parent or guardian completed the CoRonavIruS health Impact Survey and measures of child anxiety, depressive, irritability, and posttraumatic stress syndromes.Results. Results indicate a broad impact of the pandemic on children’s mental health, which fluctuated over the study period. Elevated local monthly COVID-19 prevalence, hospitalization, and death rates were associated with monthly elevations in children’s reported worry about contracting COVID-19 and stress related to non-pharmaceutical interventions (NPI). In turn, both elevated monthly worry about contracting COVID-19 and NPI-related stress were associated with monthly elevations in child- and parent- or guardian-report of children’s psychological distress and psychiatric syndromes.Conclusions. This study illustrates the importance of, and informs the potential design of, longitudinal research to track the broad, sustained impact of the COVID-19 pandemic on the mental health of children, who may be particularly vulnerable during the ongoing global crisis.

Published
2022

40. Review: Impact of urgent youth outpatient mental health care on patient and health system outcomes - a scoping review

Author

Mary Xie, Michael Wodzinski, Amy Gajaria, Marco Battaglia, and Amit Rotem

Subjects
Psychiatry and Mental health, Pediatrics, Perinatology and Child Health
Abstract

Young people often face barriers to psychiatric care and are increasingly seeking crisis services for mental health issues through the emergency department (ED). Urgent psychiatric care models provide youth in crisis with rapid access to time-limited mental health care on an outpatient basis. This scoping review aims to evaluate the impact of such urgent psychiatric services for youth aged 13-25 on patient and health system outcomes.We conducted a literature search on PubMed, EMBASE, MEDLINE, PsycINFO, and the Cochrane Database of Systematic Reviews for studies published from inception to November 20, 2020. We included studies that described outpatient psychiatric services designed for youth aged 13 to 25, took place in a clinical setting, and offered any combination of assessment, treatment, and referral. We excluded studies describing suicide intervention programmes.Our search yielded six studies, four of which were descriptive studies and two of which were randomized controlled trials. Most studies found that access to urgent psychiatric care for youth was associated with reduced ED volumes, fewer health system costs, and fewer hospitalizations. None of the studies presented evidence that urgent psychiatric services are associated with improved patient symptomatology or functioning.The results of this scoping review highlight the scarcity of robust evidence evaluating the effectiveness of urgent care for youth mental health. Further experimental studies and a set of standardized quality measures for evaluating these services are needed to bridge this critical gap in mental health care for youth in crisis.

Published
2022

41. COVID-19 Impacts on Child and Youth Anxiety and Depression: Challenges and Opportunities

Author

Darren B. Courtney, Priya Watson, Marco Battaglia, Benoit H. Mulsant, and Peter Szatmari

Subjects
medicine.medical_specialty, 2019-20 coronavirus outbreak, Adolescent, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, 03 medical and health sciences, 0302 clinical medicine, Pandemic, medicine, Child and adolescent psychiatry, Humans, 030212 general & internal medicine, Child, Psychiatry, Pandemics, Depression (differential diagnoses), Depressive Disorder, business.industry, COVID-19, Anxiety Disorders, 030227 psychiatry, Psychiatry and Mental health, Invited Commentaries, Anxiety, medicine.symptom, Coronavirus Infections, business, human activities
Abstract

No abstract available Keywords: anxiety; child and adolescent psychiatry; depressive disorders.

Published
2020

42. The role of genetic and environmental factors in covariation between anxiety and anger in childhood

Author

Maria Antonietta Stazi, Giulio Centorame, Stella Sardella, Francesca Lissandrello, Simona Scaini, Corrado Fagnani, Marco Battaglia, Chiara Brombin, Scaini, S., Centorame, G., Lissandrello, F., Sardella, S., Stazi, M. A., Fagnani, C., Brombin, C., and Battaglia, M.

Subjects
medicine.medical_specialty, media_common.quotation_subject, Dizygotic twin, CBCL, Anger, Anxiety, behavioral disciplines and activities, 03 medical and health sciences, 0302 clinical medicine, mental disorders, Developmental and Educational Psychology, medicine, Child and adolescent psychiatry, 0501 psychology and cognitive sciences, media_common, 05 social sciences, Twin study, General Medicine, Heritability, medicine.disease, Childhood, Comorbidity, 030227 psychiatry, Psychiatry and Mental health, Pediatrics, Perinatology and Child Health, behavior and behavior mechanisms, medicine.symptom, Psychology, 050104 developmental & child psychology, Clinical psychology
Abstract

Higher levels of anger expression, as well as lower levels of anger control, have been reported for adults with anxiety disorders compared to individuals without anxiety disorders. Different to the research on adults, very few studies examined the relationship between anxiety and anger in childhood. In our study, we investigated 398 Italian twin pairs (74 MZ male, 70 MZ female, 134 same-sex dizygotic-53 male, 81 female-, and 120 unlike-sex dizygotic twin pairs), aged 8–17 (mean 13.06 ± 2.59): (i) the heritability of a childhood anger phenotype; (ii) the association between five anxiety domains and anger; (iii) the role of possible common etiological factors in explaining the observed comorbidity and overlap in the risk between anxiety phenotypes and anger. The study demonstrated that anger, assessed by CBCL items, is heritable in children at a similar rate to prior studies (40%). Our research found low to moderate rate of correlation between anger and anxiety (from 0.10 to 0.19). Finally, the present study found that the majority of etiological influences on anxiety and anger are independent of each other. Data showed that shared environmental influences have some small effects on the phenotypic covariation between the anxiety phenotypes and anger (12%); whereas unique environmental influences have an almost negligible effect (1%). Our analyses did not reveal the effect of genetic effects in explaining the covariation between these phenotypes.

Published
2020

43. Twin studies of the covariation of pain with depression and anxiety: A systematic review and re-evaluation of critical needs

Author

Waqas Ullah Khan, Marco Battaglia, and Giorgia Michelini

Subjects
Depression, business.industry, Cognitive Neuroscience, Quantitative sensory testing, MEDLINE, Pain, Anxiety, Twin study, Original data, Behavioral Neuroscience, Neuropsychology and Physiological Psychology, Systematic review, Etiology, Humans, Twin Studies as Topic, Medicine, Gene-Environment Interaction, medicine.symptom, business, Depression (differential diagnoses), Clinical psychology
Abstract

Pain often co-occurs with depression and anxiety, and together cause considerable social and economic burden. Twin studies have investigated the aetiology of these covariations. However, to our knowledge, no systematic review examining the covariation between these conditions has been conducted. We searched the Cochrane Database of Systematic Reviews, EMBASE, MEDLINE, and PsychInfo for twin studies examining the covariation between pain with depression and/or anxiety published from inception to May 16, 2019. Included studies reported: original data on twin samples using the classical twin or co-twin control designs; investigated the association between pain and depression and/or anxiety; were published in peer-reviewed journals; used validated measures; included ≥100 twin pairs. Of 359 retrieved articles, 23 met our inclusion criteria. Most studies found that the covariation of pain with depression and/or anxiety was explained by genetic (n = 6) or both genetic and environmental (n = 16) factors. Most studies were cross-sectional, and all were led in adult populations. Future research requires the use of more standardized measurement tools, including quantitative sensory testing as well as assess child-adolescent cohorts.

Published
2020

44. Erratum to: Search for diboson resonances in hadronic final states in 139 fb−1 of pp collisions at √s = 13 TeV with the ATLAS detector

Author

M. Franklin, Philippe Calfayan, Ioannis Manthos, P. van Gemmeren, Martin Sykora, Gabriel John Facini, Michel Janus, Francesco Giuseppe Gravili, Valerio Bortolotto, Dirk Duschinger, Nico Giangiacomi, Laurent Serin, Edgar Kellermann, Andrew Chisholm, Kaushik De, Damir Duvnjak, Georgios Iakovidis, Daniela Boerner, Albert Olariu, Mikhail Demichev, Samuel Dysch, Valerio D'Amico, Marcelo Vogel, A. Ezhilov, Libor Nozka, A. Onofre, Jan Stark, Ingo Bloch, L. A. M. Wiik-Fuchs, Henry Lubatti, Marta Maria Perego, E. Yu. Soldatov, Raquel Pezoa, Louis D'eramo, Niklaus Lehmann, K. O. H. Vadla, Lidia Smirnova, Laurent Chevalier, Tetiana Hryn'ova, Louie Corpe, Kerstin Jon-And, Yanjun Tu, Kiyotomo Kawagoe, Daniel Guest, Tairan Xu, Giuseppe Lerner, Michael Ughetto, Milos Lokajicek, Mariusz Przybycien, Michael Andrew Parker, Tyler James Burch, Y. Kulchitsky, Liang Guan, Elias Michael Ruttinger, Calin Alexa, Fabrizio Napolitano, Y. Zhang, Stephanie Majewski, Ulrich Parzefall, M. Ziolkowski, Scott Snyder, Brian Moser, Carlos Lacasta, Masaya Ishino, R. Goncalves Gama, Amanda Steinhebel, Vincent Garonne, Sandro Palestini, Robert Les, Oleg Brandt, Didier Alexandre, J. Llorente Merino, Tingting Cao, Remi Lafaye, N. L. Abraham, Radim Slovak, B. R. Mellado Garcia, Johannes Erdmann, Sara Ghasemi, Naim Bora Atlay, H. Zhang, Philippe Mermod, Alexander Sakharov, Joseph Haley, Thorben Swirski, F. Wang, Michel Vetterli, Heidi Sandaker, Sten Hellman, Steve Muanza, Alexis Roger Louis Vallier, R. Cherkaoui El Moursli, Dimitrios Sampsonidis, R. Teixeira De Lima, Imma Riu, Rebecca Anne Linck, J. Manjarres Ramos, W. K. Di Clemente, Daniil Ponomarenko, Krzysztof Ciesla, Tomas Sykora, Valery Schegelsky, Sabrina Groh, Filip Nechansky, J. Chudoba, Fabian Wilk, Kevin Hildebrand, Bostjan Macek, L. Pedraza Diaz, A. Cueto, Y. Amaral Coutinho, Francesco Guescini, J. Barreiro Guimarães da Costa, Michela Paganini, Sergey Burdin, Dmitry Emeliyanov, Yasuhiro Makida, D. Vazquez Furelos, Jorge Andres Lopez Lopez, Baptiste Ravina, C. Schmitt, Bing Zhou, Martin Kocian, M. Garcia-Sciveres, Yu Nakahama, L. F. Flores, M. I. Gostkin, Sally Seidel, Steve McMahon, U. Soldevila, Laurent Schoeffel, Robert Gardner, Joaquin Hoya, Jack Henry Lindon, Stefano Manzoni, A. Sanchez Pineda, G. Rahal, Massimo Lazzaroni, Simen Hellesund, W. Y. Chan, Nabila Wahab Shaikh, Gianluca Introzzi, Y. W. Liu, Eva Hansen, Ryan Christopher Edgar, Martina Laura Ojeda, Zoya Karpova, Ki Lie, Helge Christoph Beck, Andrea Sansoni, Francesco Cirotto, Kyungeon Choi, Nicola Semprini-Cesari, Andrew Ferrante, Zachary Michael Schillaci, Kira Abeling, Martin Spousta, Fumihiko Ukegawa, Andrea Formica, Kentaro Kawade, Kerstin Lantzsch, Milene Calvetti, Oldrich Kepka, Oxana Smirnova, Christoph Falk Anders, Atanu Pathak, Akihiro Higashida, Daniel Lellouch, Wei Wang, Martine Bosman, Venetios Polychronakos, Sergio Gonzalez-Sevilla, Giulio Tiziano Forcolin, Pamela Ferrari, Dominique Pallin, Christos Bakalis, Armin Michael Nairz, Marzieh Bahmani, Konstantinos Bachas, Maike Christina Hansen, Michael Pitt, Laurent Vacavant, Sw. Banerjee, Suyog Shrestha, Steffen Maeland, S. Chen, Jovan Mitrevski, Luigi Longo, S. De Cecco, E. K. U. Gross, Göran Jarlskog, Sebastian Heer, Jannik Geisen, Marco Schioppa, Nikolaos Konstantinidis, Sebastian Mergelmeyer, R. D. Schamberger, Hanna Maria Borecka-Bielska, Giancarlo Spigo, Kathleen Whalen, John Kenneth Anders, S. Marti-Garcia, Vasiliki A Mitsou, Hongfang Liu, Ondrej Hladik, Athina Kourkoumeli-Charalampidi, Tomas Jakoubek, Krisztian Peters, Pascal Pralavorio, T. R. V. Billoud, Daniele Zanzi, Gonzalo Enrique Orellana, Lamberto Luminari, Simon Holm Stark, Shuwei Ye, Branislav Ristic, Y. W. Y. Ng, C. Garcia-Argos, Andrey Ryzhov, Andrea Bocci, Per Edvin Sidebo, Alberto Aloisio, Isabel Nitsche, Maciej Trzebinski, Vladimir Zhulanov, P. S. Wells, Alix Fell, Brian Le, Tetiana Moskalets, Loic Valery, Ryszard Stroynowski, Emily Marie Duffield, Valerio Ippolito, Agnieszka Ewa Ogrodnik, Polina Nechaeva, Esra Mohammed Shrif, Marco Valente, I. P. J. Shipsey, Deepak Kar, M. A. Pleier, Ji Zhu, Stuart Derek Walker, Gabriella Sciolla, A. Polini, Qiang Li, Bakar Chargeishvili, Jianming Qian, Andrew Hard, Markus Cristinziani, Nadav Michael Tamir, Efstathios Karentzos, Ivan Sykora, Abraham Seiden, Daniel Lawrence Briglin, Dave Charlton, Rachel Hyneman, Hulin Wang, Monique A. M. Gignac, Emmanuel Sauvan, Nedaa Asbah, S. De Castro, Thomas Meideck, Konstantin Beloborodov, Alexey Anisenkov, Nikita Belyaev, Ann Miao Wang, G. Duckeck, Vaclav Vacek, V. Andrei, Federica Legger, Elizaveta Shabalina, Harry James Moss, Sanmay Ganguly, P. Gadow, Sergey Karpov, Johannes Josef Junggeburth, Kenji Hamano, Corinne Goy, Shyam Balaji, Ahmed Hasib, Gabriella Gaudio, Cecilia Tosciri, Stanislav Pospisil, Louis Fayard, Thorwald Klapdor-kleingrothaus, Savanna Marie Shaw, A. Mirto, Stephen Albert Weber, Magdalena Slawinska, Shaojun Sun, Marc Escalier, Victor Solovyev, Clara Troncon, Sabrina Sacerdoti, I. M. Gregor, Tetsuro Mashimo, Hassane Hamdaoui, Luka Kanjir, Peter Charles Mcnamara, Stefania Xella, Fr Pastore, Jeanette Lorenz, David Milstead, Jia Jian Teoh, Ahmed Bassalat, Kevin Einsweiler, Fabian Becherer, Victor Maleev, Karl Jakobs, Ambrosius Thomas Vermeulen, Garabed Halladjian, Andreas Honle, Alyssa Montalbano, John Baines, S. Ketabchi Haghighat, E. V. Bouhova-Thacker, Timothy Andeen, Adam Maxwell Azoulay, E. Petit, Andrey Minaenko, Ariel Schwartzman, Stefania Spagnolo, Peter Johannes Falke, Klaus Hamacher, Tatiana Klioutchnikova, Terry Richard Wyatt, A. T. Watson, James Boyd, J. A. Wilson, Carlo Enrico Pandini, M. De Santis, Daniel Muenstermann, Nicolas Morange, Chung-Yau Lo, Andrey Soukharev, A. Nag Nag, Sergei Chekanov, Ourania Sidiropoulou, Sinem Simsek, Jonathan Butterworth, Julia Hrdinka, P. J. Clark, P. H. Sales De Bruin, Anum Qureshi, David DeMarco, J. M. P. Pasner, C. Young, Nurcan Ozturk, Nacim Haddad, Emre Celebi, Olivier Arnaez, Alexandra Tudorache, C. A. Solans Sanchez, Matthew Berg Epland, Giulia Gonella, Jelena Jovicevic, Kohei Yorita, Nansi Andari, Lianyou Shan, Richard Nisius, Cristinel Diaconu, O. Cakir, Virginia Ruth Bailey, Mario Campanelli, Joseph Reichert, Markus Schumacher, Elliot Lipeles, Saleh Sultansoy, Antonio Salvucci, S. Timoshenko, Russell James Turner, Laurie Iain McClymont, Haiping Peng, Borut Paul Kerševan, Anjishnu Bandyopadhyay, Janet Dietrich, Gustaaf Brooijmans, Lesya Anna Horyn, Tom McCarthy, Y. Li, Kilian Rosbach, Ehud Duchovni, Alexander Zaitsev, Koki Maekawa, Takahiro Fusayasu, Anjali Krishnan, Helena Santos, Gabriela Navarro, Veronica Fabiani, Melissa Ridel, Deshan Kavishka Abhayasinghe, Aranzazu Ruiz-Martinez, Giovandomenico Carducci, G. A. Chelkov, Sebastien Rettie, Amal Vaidya, Andre Schoening, Laura Jean Bergsten, S. V. Zeißner, Shi Che, Zihao Jiang, Yoav Afik, Timon Heim, J. Machado Miguens, A. Lanza, P. J. Hsu, Shogo Kido, Michael David Werner, Ioannis Nomidis, Francesco Lanni, Nikolai Fomin, Kristin Lohwasser, Sigve Haug, Mattias Birman, Joern Grosse-Knetter, E. Torró Pastor, Sergio Grancagnolo, Archil Durglishvili, Hella Leonie Snoek, Jean-Francois Grivaz, G. Otero, Ralf P. Richter, D. Rodriguez Rodriguez, Bertrand Laforge, M. El Kacimi, Akira Yamamoto, J. C. Rivera Vergara, Claudia Merlassino, Balthasar Maria Schachtner, Miriam Watson, Anastasia Kurova, A. T. H. Arce, Dirk Sammel, M. U. F. Martensson, Sven Menke, Bijan Haney, Ilya Korolkov, M. G. Alviggi, Mogens Dam, Daniel Christopher Kelsey, Andrea Sciandra, Kotaro Wakamiya, L. Bellagamba, Mazin Khader, Else Lytken, Trine Poulsen, P. de Jong, Matthias Saimpert, James Catmore, Artur Trofymov, D. Di Valentino, Tulin Varol, Hannes Mildner, Allison Mccarn Deiana, J. Jimenez Pena, M. J. Oreglia, Jean-Francois Laporte, Balazs Konya, Ina Carli, Andrew Blue, Peter Schacht, Geoffrey Gilles, Martin Spangenberg, Shigeru Odaka, Giuseppe Avolio, Givi Sekhniaidze, Juraj Smiesko, Roberto Spighi, Christopher Meyer, Sylvain Tisserant, Wolfgang Walkowiak, Jennet Dickinson, Christopher Deutsch, Christopher Samuel Pollard, Claudio Luci, Patrawan Pasuwan, Driss Benchekroun, Kunihiro Nagano, Shensheng Han, Trygve Buanes, J. Tanaka, F. A. Di Bello, Lidia Dell'Asta, Xuanhong Lou, Kathryn Grimm, Nikolai Marcel Hartmann, M. Morii, Uli Schäfer, Evangelos Gkougkousis, Sofia Adorni, Clement Camincher, E. Bergeaas Kuutmann, J. Albert, Masao Saito, V. Dao, H. Ten Kate, Simona Serena Bocchetta, A. Ventura, Y. Hernández Jiménez, Masahiro Yamatani, T. Ženiš, Fabrizio Trovato, Francesco Ragusa, Dimitris Varouchas, I. Lopez Paz, Yury Ryabov, Oleg Kuprash, V. Castillo Gimenez, Fabrice Hubaut, Ben Carlson, M. Wittgen, Petr Sicho, R. S. P. Mueller, Auriane Canesse, Carlos Escobar, E. D. Mendes Gouveia, Speranza Falciano, Geoffrey Mullier, Fabrice Balli, Tobias Kupfer, Georgios Zacharis, Alexander Gavrilyuk, Apostolos Tsirigotis, D. Levin, Bianca Monica Ciungu, C. A. Johnson, Jyoti Prakash Biswal, Karsten Köneke, E. von Toerne, Henrik Oppen, Jing Wang, Julien Caudron, Juraj Bracinik, Vit Vorobel, N. D. Dann, Petr Jacka, Manfredi Ronzani, Zineb Idrissi, John Rutherfoord, Dwayne Patrick Spiteri, Xiaohu Sun, Douglas Davis, Toshi Sumida, Diane Cinca, Fabien Jeanneau, Luca Fiorini, Jianqiao Ye, Marco Lavorgna, Frederic Deliot, J. J. Lozano Bahilo, Jacob Henry Rawling, Jing Guo, Patrick Scholer, Asma Hadef, Rachid Mazini, Joyful Elma Mdhluli, Tomoya Iizawa, Lydia Brenner, Emily Nurse, Merve Sahinsoy, D. Pohl, J. K. K. Liu, Elizabeth Gallas, Antonio Boveia, Gabriel Palacino, Arthur Rene Chomont, Jonathan Shlomi, W. Fedorko, Victor Sorin Martoiu, Bmm Allbrooke, Takanori Kono, Petr Balek, A. T. Doyle, Gregorio Bernardi, Johannes Balz, C. Di Donato, Xing Long Li, Francesco Spanò, Z. Liang, Edoardo Maria Farina, Takuto Kunigo, Zvi Hirsh Citron, Oleg Meshkov, Benedetto Giacobbe, O. M. Kind, Paul Gessinger-Befurt, Fernando Barreiro, O. E. Vickey Boeriu, Giuseppe Salamanna, Ines Ochoa, Helmut Wolters, Y-H. Chen, Gavin Pownall, Robert J. Bielski, Tomas Kosek, S. Yang, Sara Caroline Alderweireldt, Douglas Benjamin, Zuzana Rurikova, Francesco Maria Follega, Wouter Verkerke, V. Araujo Ferraz, Sergey Kuleshov, Nataliia Zakharchuk, Revital Kopeliansky, Harshna Jivan, Milena Bajic, Takashi Kubota, Raphael Vuillermet, Martina Javurkova, Hadar Yosef Cohen, F. J. Munoz Sanchez, Emma Sian Kuwertz, C. Adam Bourdarios, Ren-You Zhang, Mikhail Mineev, M. C. N. Fiolhais, Georges Aad, Antoine Marzin, Peter Tornambe, D. M. Strom, David William Thomas, Nikola Makovec, Jelena Krstic, Adam Trzupek, Anamika Aggarwal, Priscilla Pani, Rhys Edward Owen, Duc Ta, Alexey Boldyrev, Claudia Glasman, Simon Berlendis, Yoshiji Yasu, A. Andreazza, Evgeniy Khramov, Andrew Washbrook, Emilio Higón-Rodriguez, L. B. A. H. Hommels, M. Rescigno, Michael Hance, Yuji Minegishi, J. W. Smith, Carlos Sandoval, Tasneem Rashid, Will Davey, Alberto Cervelli, Maria Giulia Ratti, J. Kroll, A. Pacheco Pages, Nguyen Phuong Dang, Hidetoshi Otono, Torre Wenaus, A. J. Barr, Julian Wollrath, Yoram Rozen, F. Luehring, R. M. Faisca Rodrigues Pereira, Andreas Redelbach, Hiroshi Sakamoto, T. S. Lau, Luca Martinelli, Gen Kawamura, Are Sivertsen Traeet, Kevin Black, Y. Delabat Diaz, A. G. Clark, Ahmet Bingul, Elzbieta Richter-Was, Michal Marcisovsky, Adam James Bozson, Martin Aleksa, Elliott Cheu, Lotte Ansgaard Thomsen, Ferdinand Schenck, F. Lasagni Manghi, Dominic Hirschbuehl, Srinivasan Rajagopalan, Anne Marie Sickles, Matthew Edgar Leblanc, G. Lehmann Miotto, C. M. Vergel Infante, O. Estrada Pastor, Louise Heelan, Daniel Froidevaux, Sebastian Andreas Merkt, Fabio Tresoldi, Davide Melini, Gideon Bella, Alexandre Laurier, Carmen Maidantchik, L. Manhaes de Andrade Filho, A. P. Pereira Peixoto, Tae Hyoun Park, Zhidong Zhang, Barbara Wosiek, Marc Geisen, J. E. M. Robinson, Farid Ould-Saada, R. Iuppa, Elodie Deborah Resseguie, Hoang Dai Nghia Nguyen, Hal Evans, D. Fassouliotis, Enrico Pasqualucci, Marta Lidia Rimoldi, P. Bokan, Junpei Maeda, John Huth, Roberto Ferrari, Regina Moles-Valls, Konstantin Toms, Grigore Tarna, Konstantin Lehmann, Robert Arthur Mina, Alexey Zhemchugov, Dms Sultan, James Mueller, Kerim Suruliz, Jacqueline Batley, Roland Jansky, Antoine Laudrain, Florian Beisiegel, Elizabeth Brost, C. A. Marin Tobon, Osamu Sasaki, Christopher Grud, Boping Chen, S. George, Yongsheng Gao, Monika Wielers, C. F. Feng, Adam Edward Barton, Babar Ali, C. Bohm, Halina Abramowicz, Marco Montella, Andrii Verbytskyi, Artem Maevskiy, Mark Kruse, Alison Lister, D. Kobayashi, G. Zhang, Marlon Barbero, V. V. Lyubushkin, David Rousseau, Jakita O. Thomas, A. Bethani, Kerstin Tackmann, Olga Novgorodova, D. Su, Eric Lancon, David Paul Yallup, K. K. Gan, Maria Giovanna Foti, Brian Petersen, Namig Javadov, Alex Martyniuk, Wolfgang Wagner, Shohei Shirabe, Marie-Hélène Genest, Tamar Djobava, Sinan Kuday, R. Camacho Toro, Jan-Ulf Mjörnmark, Katja Hannele Mankinen, Igor Mandić, Thomas Daniel Weston, Yongke Zhao, Shuyang Hu, Anna Sfyrla, T. Theveneaux-Pelzer, Savannah Jennifer Thais, Nora Emilia Pettersson, Zinonas Zinonos, Margaret Susan Lutz, A. Korn, Paul Tipton, Oliver Majersky, Robert Hankache, Michael William Phipps, Vincent Hedberg, Yang Yang, A. Ferrer, Christopher Blake Martin, William Patrick McCormack, Adrian John Bevan, Mariyan Petrov, Mohamed Ouchrif, Christopher Willis, Silvia Franchino, L. F. Oleiro Seabra, Allen Mincer, Anatoly Kozhin, Ryan Justin Atkin, David Francis, Marcello Fanti, A. De Santo, Federico Scutti, Serban Protopopescu, Igor Boyko, Jerome Samarati, Adrian Chitan, Ning Zhou, Benjamin Wynne, Bengt Lund-Jensen, Donatas Ramilas Zaripovas, C. H. Chen, Andrey Sapronov, Nicolas Berger, Ivan Pogrebnyak, J. A. Parsons, Matteo Franchini, Ester Ricci, Lennart Adam, Stefan Koperny, Julie Kirk, Craig Sawyer, Susanne Kersten, Aidan Grummer, Sebastian Grinstein, Fabio Cerutti, Wolfgang Mader, A. De Salvo, Radek Novotny, Koji Terashi, Kelsey O'Connor, S. Hageböck, Peilian Liu, Benedikt Bergmann, Raimund Ströhmer, Audrey Ducourthial, Johannes Elmsheuser, Klaudia Burka, Fabrizio Scuri, Sergey Peleganchuk, Craig Buttar, M-S. Barisits, Ken-ichi Uchida, Rachik Soualah, Michele Pinamonti, Sabine Lammers, Samuel Joseph Crawley, Yuya Kano, Paola Giannetti, Susumu Oda, James Broughton, Julien Donini, Volker Büscher, J. S. Keller, Luca Ambroz, A. T. Goshaw, Hernan Wahlberg, Sune Jakobsen, Fernando Monticelli, Wenhao Xu, Elena Yatsenko, D. E. Ferreira de Lima, Andrey Kamenshchikov, S. Prell, Peter Krieger, Craig Wiglesworth, Lluisa-Maria Mir, Aaron Foley Webb, E. J. W. Moyse, Stewart Martin-Haugh, H. Bahrasemani, Ruth Magdalena Jacobs, Maosen Zhou, D. I. Narrias Villar, Alessandro Lapertosa, Stephen Hillier, M.A. Haleem, Noemi Calace, Luis Hervas, Filip Backman, D. Boscherini, Michele Renda, Thomas Philippe Calvet, Andy Haas, Laser Seymour Kaplan, Salvatore Loffredo, Yicheng Guo, Andrea Matic, Liang Li, Francois Vazeille, Mariya Shiyakova, Feng Lyu, D. Pietreanu, Jie Zhang, Giacomo Artoni, Sandra Kortner, M. I. Martínez, Filipp Dubinin, Jessica Metcalfe, James H Cochran, Marcela Mikestikova, Matthew Feickert, Michele Livan, Q. J. Li, Ikuo Ueda, Giuliano Gustavino, Alexi Gongadze, Giovanni Darbo, Stefan Simion, Marianna Testa, Holly Ann Pacey, Annick Lleres, Danilo Giugni, Daniel Whiteson, Otmar Biebel, Graeme Stewart, Peilong Wang, Takuya Nobe, Alexander Melzer, Angela Maria Burger, Michael Adersberger, Gino Marceca, Matthias Schott, Maximilian Swiatlowski, C. Haber, Hai Jiang, Tomoki Saito, Tina Sfiligoj, Saverio D'Auria, Oliver Stelzer-Chilton, Oliver James Winston, K. Potamianos, D. J. Lewis, Guy Rosin, H. J. Yang, Jamal Eddine Derkaoui, Monica Trovatelli, A. A. E. Bannoura, Mattias Ellert, M. Losada, P. M. Tuts, Lene Bryngemark, Gianluca Alimonti, Rainer Stamen, Franziska Iltzsche, Sergey Barsov, Jacob Julian Kempster, Christos Anastopoulos, Y. L. Liu, Jindong Li, Timothy Barklow, Daria Zieminska, Sebastian Liem, P. C. F. Glaysher, Junichi Kanzaki, Sabrina Perrella, Joao Seixas, Alan James Taylor, Philip Phillips, Samuel Silverstein, Chav Chhiv Chau, Philipp Thomas Koenig, Wing Sheung Chan, Jeffrey David Shahinian, Gerjan Bobbink, Marisilvia Donadelli, Yongsun Kim, Olga Igonkina, D. Shaked Renous, Sarah Jones, James Walder, Nurfikri Bin Norjoharuddeen, Filippo Ceradini, Adam Kaluza, Veronique Boisvert, Hideyuki Oide, Dugan O'Neil, T. Yamazaki, Antony Fray, Janna Katharina Behr, Yury Smirnov, Charles William Kalderon, Alexander Cheplakov, Robin Hayes, S. R. Hou, Mika Huhtinen, Julien Maurer, Benoit Lefebvre, Anna Kathryn Duncan, Bernardo Sotto-Maior Peralva, H. Meyer Zu Theenhausen, Manuella Vincter, F. A. Jimenez Morales, Daniel Turgeman, Magnar Kopangen Bugge, D. Chakraborty, Zhongyukun Xu, Michael Schernau, Till Eifert, K. Al Khoury, Abner Soffer, Lily Asquith, K. De Vasconcelos Corga, Ayda Beddall, Andrea Gaudiello, Jana Faltova, Alexey Kharlamov, Vadim Kostyukhin, M. 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Ravinovich, David Robinson, Kunlin Han, Ladislav Chytka, Tatsumi Nitta, Vasiliki Kouskoura, Emma Winkels, J. P. Thomas, Dusan Bruncko, Takahiko Kondo, Nicolas Scharmberg, Jun Gao, Igor Potrap, Jason Veatch, Kenta Uno, Stefan Kluth, A. L. Lionti, Elena Plotnikova, A. J. Lankford, L. Han, Tancredi Carli, Roberto Cardarelli, Jaroslav Guenther, Geoffrey Henry Herbert, Vasilis Konstantinides, Marcella Bona, Igor Gavrilenko, Matteo Bauce, Vassili Kazanin, Michael Holzbock, Rohin Narayan, Nathalie Besson, Benedict Tobias Winter, Ivana Hristova, Yu Him Justin Chiu, Laura Brittany Havener, Edisher Tskhadadze, Martin White, Eric Feng, Sahal Yacoob, W. Ding, S. Cabrera Urbán, B. H. Brunt, K. Papageorgiou, Josef Pacalt, D. M. Gingrich, Dingane Reward Hlaluku, Enrico Rossi, D. De Pedis, Alberto Stabile, Shlomit Tarem, Nishu Nishu, Gavin Grant Hesketh, Tiesheng Dai, Debarati Roy, Christian Luedtke, Iwona Grabowska-Bold, R. Caminal Armadans, Binish Batool, Bruno Galhardo, R. Di Sipio, Michael James Fenton, Chase Owen Shimmin, Kristina Anne Looper, Deywis Moreno, B. Di Micco, Oleg Solovyanov, Ulrike Schnoor, S. Malyukov, Jan Schaeffer, B. Safarzadeh Samani, Christian Gutschow, Kurt Brendlinger, S. P. Y. Yuen, Valeria Nikolaenko, Serban Constantinescu, Adele Rimoldi, A. P. Colijn, Terutaro Nakamura, Kristof Schmieden, Margherita Spalla, G. A. Cowan, Martin Nagel, Paul Dervan, I. van Vulpen, Rui Zou, Giulio Aielli, T. Lari, Johannes Frederic Damp, Alexander Bogdanchikov, C. Zeitnitz, Paolo Sabatini, Arnulf Quadt, Mikhail Levchenko, J. Urban, Gabriel Gallardo, D. Paredes Hernandez, Jiangyong Jia, Stefano Terzo, Kevin Kroeninger, Helen Hayward, Takashi Yamanaka, Elemer Nagy, Juan Pedro Ochoa-Ricoux, M. Mikuž, Shunsuke Honda, Marie Christine Lanfermann, Peter Jenni, V. S. Bobrovnikov, Alexey Maslennikov, F. Anulli, Ben William Whitmore, Akanksha Vishwakarma, Wladyslaw Dabrowski, Zekeriya Uysal, Brian Cole, Arka Santra, Andrej Filipcic, R. F. Naranjo Garcia, Adam Jinaru, C. N. P. Gee, Artem Basalaev, Kamil Augsten, Serkant Ali Cetin, Gerhard Ferdinand Rzehorz, R. P. Middleton, Rhys Thomas Roberts, Shan Jin, Sandra Leone, Marek Palka, A. M. Henriques Correia, Joseph Stanford Ennis, Christos Lampoudis, Lydia Roos, Yi-Tao Wang, Kazuya Mochizuki, Peter Love, Maximilian Georg Herrmann, H. S. Chen, Benjamin William Allen, David Dodsworth, Stefanie Todt, Kenneth Wraight, Yu-Ting Shen, Ivor Fleck, Sofiia Hyrych, V. Kartvelishvili, Santiago Juan Batista, Raymond Brock, G. Mikenberg, Giovanni Crosetti, Stefania Antonia Stucci, Giovanna Bruni, Klaus Mönig, A. M. Rodríguez Vera, Florian Bauer, S. Yu. Smirnov, Sebastian Artz, J. Proudfoot, Patrick Czodrowski, James Andrew Kendrick, Kayla Dawn McLean, M. Faucci Giannelli, Jonathan Crane, Karol Krizka, Stefan Gadatsch, M. A. L. Leite, Evangelos Gazis, Mathis Kolb, Eftychia Tzovara, Johannes Donatus Mellenthin, Matej Melo, Lorenzo Feligioni, Joleen Pater, Filomena Sopkova, N. Viaux Maira, Adomas Jelinskas, Kazuki Motohashi, Karel Cerny, Alessandro Gabrielli, Y. Jiang, Matthew Peter Heath, Chris Hays, Tord Ekelof, Monica Verducci, Stephen Sekula, Arthur Schaffer, Xifeng Ruan, Vladimir Tikhomirov, Ioulian Budagov, Makoto Tomoto, Lewis Joseph Wilkins, Yahya Tayalati, Ph. Schune, W-M. Yao, S. J. Lee, Claude Guyot, Gabriele Chiodini, Sinead Farrington, Georg Zobernig, E. Sideras Haddad, Wade Cameron Fisher, David Reikher, Takuya Tashiro, D. della Volpe, Thomas Peiffer, Christopher Hayes, Mario Grandi, P. A. Delsart, C. P. A. Roland, Mario Spina, Yoji Hasegawa, Matei Eugen Vasile, Juan Pedro Araque, Eduard Kladiva, Mjr Olsson, L. Aperio Bella, A. Farilla, Pedro Teixeira-Dias, Nicoletta Garelli, Michael R. Wessels, K. J. C. Leney, A. M. Cooper-Sarkar, Giacinto Piacquadio, Florian Hinterkeuser, L. L. Ma, Kalliopi Iordanidou, Aaron Liblong, Nadezda Proklova, Yun Sang Chow, Declan Andrew Millar, J.-H. Arling, Andrzej Smykiewicz, Stefano Camarda, Simona Gargiulo, Syed Haider Abidi, Ketevi Assamagan, Theodor Christian Herwig, Leonardo Paolo Rossi, Marzio Nessi, Jeremy Love, Rachael Ann Creager, Fudong He, Andrea Negri, Alberto Valero, Stefano Giagu, Alessandro Cerri, Jennifer Kathryn Roloff, Rinat Fakhrutdinov, A. Juste Rozas, Nicolo Vladi Biesuz, Kendall Reeves, Paul Jackson, S. R. Paredes Saenz, Philip Bechtle, A. Glazov, Filipe Veloso, Christos Vergis, Nenad Vranjes, R. M. D. Carney, Elena Rocco, Oliver Ricken, Jan Jongmanns, Monika Mittal, Dewen Zhong, Thomas James Stevenson, Jens Janssen, Pavel Staroba, Minyu Feng, Jemal Khubua, Merve Nazlim Agaras, Alexander Mann, Qipeng Hu, S. Campana, Annabelle Julia Chuinard, Yang Qin, Sophie Trincaz-Duvoid, Kazuhiko Hara, Irina Antonela Cioara, Matthew James Sullivan, Mariel Nelson Pettee, Sarah Demers, Johann Collot, Giordon Holtsberg Stark, Daniela Salvatore, Katsuo Tokushuku, Christophe Clement, Arnaud Dubreuil, Gaetano Barone, F. Rauscher, P. Skubic, Emery Nibigira, M. Del Gaudio, Dominik Derendarz, Johan Sebastian Bonilla, J. Beringer, J. Griffiths, Marco Scodeggio, Antonio Giannini, Audrey Katherine Kvam, Michel Lefebvre, Miroslav Myska, Elliot Reynolds, Rosy Nicolaidou, Francesco Gonnella, Mark Neubauer, Giorgi Arabidze, Kosuke Takeda, Darren Price, Fedor Prokoshin, Pierre Savard, Paul Fraser Harrison, Takuya Honda, D. Oliveira Damazio, Janusz Chwastowski, Sharka Todorova-Nova, Matthew Craig Mondragon, Frued Erik Braren, P. U. E. Onyisi, A. Di Girolamo, Edson Carquin, Fumiya Yamane, Christian Grefe, Robert Johannes Langenberg, L. Di Ciaccio, Mohammad Jawad Kareem, Pavel Murin, S. Willocq, Matthew Glenn Kurth, Vincenzo Canale, Vakhtang Tsulaia, Pavel Podberezko, Stewart Patrick Swift, Sarah Louise Barnes, David Cameron, John Stupak, Tomas Blazek, Giulia Ripellino, Julian Constantin Schmoeckel, Tomasz Bold, Yuta Okazaki, Yann Coadou, Faig Ahmadov, Blake Burghgrave, Karishma Sekhon, Salah-eddine Dahbi, Monica Dobre, Felix Fidelio Klitzner, Thibault Guillemin, Caterina Marcon, Umar Gul, Siegfried Bethke, Caterina Doglioni, Stanislav Tokár, J. Ocariz, Arnaud Duperrin, Heather Gray, Steven Williams, Andrey Karyukhin, M. Reale, R. M. Barnett, S. Y. Suzuki, Riccardo Vari, Maria Pilar Casado, Dennis Perepelitsa, Emma Tolley, Michaela Mlynarikova, Ian Brock, G. Eigen, Hicham Atmani, Mirta Dumancic, S. J. Chen, F. Safai Tehrani, Adrian Buzatu, R. Kowalewski, Andrei Alexandru Geanta, Albert Francis Casha, Robert Stanek, J. Huston, Souad Batlamous, Vanja Morisbak, T. R. Van Daalen, Tobias Flick, Gabriele D'amen, Lukasz Zwalinski, Andreas Reiss, Masahiro Morinaga, Sheena Schier, D. Camarero Munoz, Chrysostomos Valderanis, Yohei Yamaguchi, Peter Kodys, Venugopal Ellajosyula, Val O'Shea, T. Vazquez Schroeder, Aishik Ghosh, Paolo Morettini, Silvia Biondi, Alessia Murrone, Peter Buchholz, George Dyckes, K. F. Di Petrillo, Zdenek Dolezal, Mark Sutton, Abdeslam Hoummada, Laura Jeanty, Luca Pizzimento, Krystsina Petukhova, Alexandros Marantis, R. R. M. Fletcher, R. de Asmundis, Marek Tasevsky, Matthias Danninger, Dylan Perry Kisliuk, Uladzimir Kruchonak, R. W. L. Jones, Ovsat Abdinov, Oleg Zenin, Ismet Siral, J. Rothberg, Dimitrios Iliadis, Goetz Gaycken, Steven Worm, Sabine Crépé-Renaudin, Stavros Maltezos, Carsten Daniel Burgard, Bernd Stelzer, Maria Florencia Daneri, Kingman Cheung, Josu Cantero, N. B. Sinev, Hiroyuki Iwasaki, John-Bjarne Hansen, Bogdan Malaescu, Christopher John Mcnicol, J-Y. Hostachy, A. Baroncelli, Baojia Tong, Alec Swenson Drobac, E. Le Guirriec, Clement Helsens, Lorenzo Pezzotti, S. Tapia Araya, Yasuyuki Okumura, Dmitry Golubkov, Katharina Schleicher, W. D. Breaden Madden, Nihal Brahimi, Fabian Alexander Förster, J. A. Aparisi Pozo, Alexander Emerman, D. P. J. Lack, Tohru Takeshita, Luca Colasurdo, S. Calvente Lopez, Gordon Watts, Andrea Coccaro, Sergey Senkin, Bo Liu, Veysi Erkcan Ozcan, Stefanie Morgenstern, Iskander Ibragimov, Wen Guan, Shreya Saha, Tomas Komarek, Florian Christoph Fischer, Moritz Backes, Nikolaos Tsirintanis, Artur Cardoso Coimbra, Sofia Chouridou, Maria-Teresa Dova, Alexander Sydorenko, Patrick Fassnacht, P. D. Thompson, Herjuno Rah Nindhito, Uta Klein, Kate Shaw, Maria Smizanska, Lorne Levinson, M. Li, A. V. Akimov, Michel Raymond, Bruce Schumm, Jonathan Long, K. J. R. Cormier, Efe Yigitbasi, S. A. Olivares Pino, Jolanta Olszowska, Trevor Vickey, Phillip Gutierrez, Charles Delporte, Leonardo Merola, K. Nakamura, Aytul Adiguzel, Dmitri Tsybychev, Chiara Grieco, Georges Azuelos, Thomas James Neep, Matthew Thomas Anthony, G. R. Gonzalvo Rodriguez, Kim Katrin Heidegger, Josh Mcfayden, M. Stegler, Dalila Salamani, Thomas LeCompte, Andrew Pilkington, Vitaliano Chiarella, Bobby Samir Acharya, H. A. Neal, Barry King, S. C. Lee, Hannah Herde, C. M. Hawkes, Pavol Bartos, Marina Cobal, Michael Edward Nelson, B. Martin dit Latour, Chikuma Kato, Song-Ming Wang, Jana Schaarschmidt, Matous Vozak, Dennis Sperlich, Jiri Masik, Oleg Fedin, C. P. Ward, Yohei Noguchi, Ewan Hill, Tim Scanlon, Stanislav Suchek, Christos Leonidopoulos, V. M. M. Cairo, Stamatios Gkaitatzis, Isabel Marian Trigger, F. Lo Sterzo, Mauro Villa, James Frost, Pier-Olivier Deviveiros, Jonas Strandberg, David Malon, Anna Kaczmarska, Gilberto Giugliarelli, Christian Weber, Guillaume Unal, Amir Farbin, A. Artamonov, Daniela Bortoletto, Shigeki Hirose, D. Bakshi Gupta, Tadamitsu Kishimoto, T. Kuhl, Janina Anna Krzysiak, Dimitrii Krasnopevtsev, Andrey Kiryunin, Peter Nemethy, Siarhei Harkusha, Mario Sannino, M. A. Nomura, L. Masetti, J. C. Hill, Julien-christopher Beyer, R. Piegaia, Elmar Ritsch, Verena Herget, Nello Bruscino, Philipp Stolte, Flavia De Almeida Dias, Robert Adam Vallance, Iacopo Vivarelli, Reda Tafirout, Klaus Kurt Desch, Richard Nickerson, Francisco Alonso, Arnaud Lucotte, Georgios Stavropoulos, Y. A. Kurochkin, Liza Mijović, E. Torrence, Viktor Sinetckii, Ben Smart, Augusto Santiago Cerqueira, Dmytro Hohov, Alexander Kupco, Edoardo Gorini, Evgeny Starchenko, C. Padilla Aranda, Koji Sato, D. Álvarez Piqueras, S. Yu. Sivoklokov, H. Duran Yildiz, J. Montejo Berlingen, Giuseppe Callea, Pierre-Francois Giraud, Ian Dawson, Mathieu Benoit, Saskia Falke, Xuan Yang, Mihail Chizhov, Yuji Yamazaki, Lewis James Armitage, Jinhong Yu, Veronika Magerl, Bruno Mansoulie, Paul Newman, D. Xu, Alexei Klimentov, Alexander Undrus, Anton Wolf, D. Berge, Calum Michael Macdonald, Steven Patrick Alkire, Simon Henry Connell, Tatsuya Masubuchi, Oliver Keith Baker, Jiri Kvita, Iain Alexander Bertram, Elisa Fumagalli, Francesco Crescioli, Victoria Jane Martin, Cecile Deterre, John Alison, Sara Valentinetti, Tobias Klingl, Michael Rijssenbeek, Frank Winklmeier, L. R. Flores Castillo, Emily Charlotte Graham, A. Abed Abud, Andre Rummler, Jad Zahreddine, Christine Kourkoumelis, Pedro Jorge, Juan Terron, Frederic Schroeder, Xiaocong Ai, Fang-ying Tsai, Simone Monzani, Olaf Nackenhorst, Chiara Debenedetti, H. J. Cheng, Mauro Iodice, Ruggero Turra, Maia Mosidze, S. González de la Hoz, Bernard Brickwedde, M. Beretta, Thomas Naumann, Saminder Dhaliwal, Riccardo-Maria Bianchi, K. H. Hiller, Dale Charles Abbott, R. C. W. Henderson, Joseph Izen, R. Gupta, M. J. Shochet, Aimilianos Koulouris, Alexandre Rozanov, T. Kobayashi, Yakov Petrovich Kulinich, D. Gillberg, Rupert Leitner, Chloe Gray, Luigi Vigani, Edward Diehl, Konstantinos Nikolopoulos, Devin James Mahon, Puja Saha, Daniel Stefaniak Nielsen, Claudio Santoni, Stephen Jiggins, Ruslan Mashinistov, Quentin Buat, Alessandra Ciocio, Pavel Shatalov, K. Sliwa, Kurt Keys Hill, Stephanie Zimmermann, Marcel Michael Stanitzki, Junji Tojo, Y. C. Zhu, Paolo Camarri, Stefan Tapprogge, Stephen Burns Menary, Jochen Dingfelder, Alex Kastanas, Alaettin Serhan Mete, Chaowaroj Wanotayaroj, Massimo Corradi, Mario Lassnig, A. Maio, Cheng Chen, Eric Drechsler, Bibhuti Parida, A. Di Ciaccio, Cong Geng, R. F. H. Hunter, Nathan Rogers Bernard, Driss Goujdami, Pepijn Johannes Bakker, Nima Sherafati, David Calvet, Gregory David Hallewell, Jiri Dolejsi, Alastair Dewhurst, Heinz Pernegger, Alexander Oh, Hisaya Kurashige, Martin Klassen, R. El Kosseifi, H. L. Zhu, Cesare Bini, Zhen Yan, Michael Kagan, Rodney Walker, Ke Li, David Robert Wardrope, Didier Ferrere, Marcus Morgenstern, Trisha Farooque, and Alexander Paramonov

Subjects
transverse momentum: high, Atlas detector, 13000 GeV-cms, Hadron, mass [jet], 01 natural sciences, high [transverse momentum], W: pair production, Hadron-Hadron scattering (experiments), scattering [p p], Z0: pair production, skin and connective tissue diseases, Z0: hadronic decay, vector boson: associated production, Physics, hadronic decay [Z0], new physics, mass [gauge boson], ATLAS, channel cross section: branching ratio: upper limit, pair production [Z0], CERN LHC Coll, pair production [W], final state: hadronic, lower limit [mass], gauge boson: mass, colliding beams [p p], narrow resonance, Nuclear and High Energy Physics, Particle physics, p p: scattering, mass: lower limit, boosted particle, hadronic [final state], 0103 physical sciences, ddc:530, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, High Energy Physics, structure, 010306 general physics, S056ZOT, hadronic decay [W], W: hadronic decay, branching ratio: upper limit [channel cross section], 010308 nuclear & particles physics, background, S056W1C, jet: mass, Experimental High Energy Physics, lcsh:QC770-798, S071RSG, associated production [vector boson], sense organs, p p: colliding beams, experimental results
Abstract

Journal of high energy physics 2020(6), 42 (1-19) (2020). doi:10.1007/JHEP06(2020)042, Published by SISSA, [Trieste]

Published
2020

46. A Way through the woods: Development of an integrated care pathway for adolescents with depression

Author

Joanna Henderson, Marco Battaglia, Darren B. Courtney, John Strauss, Karleigh Darnay, Kathryn Bennett, Peter Szatmari, and Priya Watson

Subjects
Male, Canada, Adolescent, medicine.medical_treatment, media_common.quotation_subject, Pilot Projects, Session (web analytics), 03 medical and health sciences, 0302 clinical medicine, Nursing, Excellence, medicine, Psychoeducation, Humans, Quality (business), Program Development, Biological Psychiatry, Depression (differential diagnoses), media_common, Depressive Disorder, Major, Cognitive Behavioral Therapy, Delivery of Health Care, Integrated, Tertiary Healthcare, Guideline, medicine.disease, 030227 psychiatry, Integrated care, Psychiatry and Mental health, Practice Guidelines as Topic, Major depressive disorder, Female, Pshychiatric Mental Health, Psychology, 030217 neurology & neurosurgery
Abstract

AIMS Depression in adolescents is common and debilitating. Treatment approaches vary widely across clinics and may not reflect evidence-based care. Integrated care pathways (ICPs) are implementation tools to facilitate bridging the gap between rigorous but often complex clinical practice guidelines and what is actually practiced. We describe the development of an ICP for the treatment of Adolescents with Major Depressive Disorder (MDD-A) based on the best-available clinical practice guidelines and derived in collaboration with clinicians, administrators, youth partners and caregivers. METHODS With clinician and health service manager input, we took the recommendations from a high quality clinical practice guideline (the National Institute of Health and Care Excellence Clinical Practice Guideline for Depression in Children and Young People) and translated them into an ICP. Feedback from youth partners and clinicians was iteratively incorporated into the current version of the pathway using a collaborative approach. RESULTS The current iteration of the pathway at a Canadian tertiary care teaching hospital is described. All youth (and caregivers, if applicable) are offered a multi-family psychoeducation session, a 16-session Group Cognitive Behaviour Therapy and team reviews every 4 weeks that include measurement-based care. Conditional branches of the pathway include a medication algorithm and an 8-session group for caregivers. CONCLUSIONS The resulting ICP provides a tool to facilitate bridging the gap between evidence and clinical practice.

Published
2019

47. Experiences of Pediatric Pain Professionals Providing Care during the COVID-19 Pandemic: A Qualitative Study

Author

Tieghan Killackey, Krista Baerg, Bruce Dick, Christine Lamontagne, Raju Poolacherla, G. Allen Finley, Melanie Noel, Kathryn A. Birnie, Manon Choinière, M. Gabrielle Pagé, Lise Dassieu, Anaïs Lacasse, Chitra Lalloo, Patricia Poulin, Samina Ali, Marco Battaglia, Fiona Campbell, Lauren Harris, Vina Mohabir, Fareha Nishat, Myles Benayon, Isabel Jordan, and Jennifer Stinson

Subjects
Pediatrics, Perinatology and Child Health, COVID-19, pediatric pain, pain clinics, distance treatments, e-health, telehealth
Abstract

Chronic pain affects 1 in 5 youth, many of whom manage their pain using a biopsychosocial approach. The COVID-19 pandemic has impacted the way that healthcare is delivered. As part of a larger program of research, this study aimed to understand the impact of the pandemic on pediatric chronic pain care delivery including impact on patients’ outcomes, from the perspective of pediatric healthcare providers. A qualitative descriptive study design was used and 21 healthcare providers from various professional roles, clinical settings, and geographic locations across Canada were interviewed. Using a reflexive thematic analysis approach 3 themes were developed: (1) duality of pandemic impact on youth with chronic pain (i.e., how the pandemic influenced self-management while also exacerbating existing socioeconomic inequalities); (2) changes to the healthcare system and clinical practices (i.e., triaging and access to care); (3) shift to virtual care (i.e., role of institutions and hybrid models of care). These findings outline provider perspectives on the positive and negative impacts of the pandemic on youth with chronic pain and highlight the role of socioeconomic status and access to care in relation to chronic pain management during the pandemic in a high-income country with a publicly funded healthcare system.

Published
2021

49. Search for New Phenomena in Final States with Two Leptons and One or No b -Tagged Jets at s=13 TeV Using the ATLAS Detector

Author

John-Bjarne Hansen, Maheyer Jamshed Shroff, Clement Helsens, Lorenzo Pezzotti, Otmar Biebel, Peilong Wang, Takuya Nobe, Shahzad Ali, Joseph Mullin, Guy Rosin, Wing Sheung Chan, Jeffrey David Shahinian, Gerjan Bobbink, Simon Berlendis, Dmitry Golubkov, Katharina Schleicher, W. D. Breaden Madden, Kirill Grevtsov, Karel Smolek, Werner Wiedenmann, M. J. Alconada Verzini, Shunichi Akatsuka, Attila Krasznahorkay, Ilija Vukotic, Lukas Ehrke, Petter Nilsson, Panagiotis Gkountoumis, Xiangke Zhang, Rui Yuan, Anna Goussiou, Marco Sessa, Marisilvia Donadelli, Elisabetta Pianori, Blair Daniel Seidlitz, A. V. Kotwal, Daniel Hayden, R. J. Teuscher, Christopher Andrew Garner, Julia Lynne Gonski, S. Pagan Griso, Federico Sforza, Maria-evanthia Tsopoulou, Nikolai Zimine, D. Amidei, Jackson Carl Burzynski, Fabian Alexander Förster, D. Gillberg, Rupert Leitner, Edward Diehl, J. A. Aparisi Pozo, Konstantinos Nikolopoulos, Devin James Mahon, Evgeniy Khramov, Hideyuki Oide, Dugan O'Neil, Andy Chen, Robert Astalos, Emmanuel Monnier, R. S. Orr, R. Hyneman, Roman Lysak, Christian Wiel, Matthieu Robin, S. Calvente Lopez, Gordon Watts, W. Y. Chan, T. S. Lau, J. W. S. Carter, Kevin Nicholas Barends, Rafal Staszewski, Gabija Zemaityte, M. R. Sutton, Li Xu, Kun Liu, Nicholas Adam Styles, R. W. Wölker, Federico Meloni, V. Izzo, Mark Owen, Didier Ferrere, Simone Francescato, Lorenzo Marcoccia, Christos Vergis, Nuno Filipe Castro, Michael James Fenton, Haifeng Li, Luigi Marchese, Dario Barberis, A. G. Clark, Igor Gavrilenko, Matteo Bauce, Puja Saha, Marcel Michael Stanitzki, Evelin Bakos, Junji Tojo, Y. C. Zhu, Paolo Camarri, Stefan Tapprogge, Y. Kulchitsky, Fabrizio Alfonsi, Artur Cardoso Coimbra, Kate Shaw, Lorne Levinson, Adam Jinaru, S. H. Tlou, P. Conde Muiño, Giancarlo Spigo, Kathleen Whalen, Athina Kourkoumeli-Charalampidi, Barbara Wosiek, Trevor Vickey, Olga Zormpa, Phillip Gutierrez, Darij Markian Starko, M. Della Pietra, Xiaohu Sun, Y. S. Ng, Jafar Shojaii, Sarah Whitney Ferguson, Andrea Catinaccio, S. Li, A. Rocchi, Arnaud Ferrari, Lingxin Meng, Marcia Begalli, Ilaria Luise, Sebastian Andreas Merkt, Gideon Bella, Massimo Corradi, Mario Lassnig, A. Maio, Marc Geisen, Teresa Barillari, Marcus Morgenstern, M. K. Ayoub, Matthew Thomas Anthony, Dewen Zhong, G. R. Gonzalvo Rodriguez, Judith Hofer, R. Di Nardo, Shangfeng Yang, Callum Jacob Birch-Sykes, Ljiljana Morvaj, Chikuma Kato, Norbert Wermes, Marjorie Shapiro, Song-Ming Wang, Thomas James Stevenson, H. Herde, Pavol Strizenec, J. Salt, K. Graham, Siegfried Wenig, Raymond Brock, M. N. Agaras, Diptaparna Biswas, A. Rodriguez Rodriguez, Cheng Chen, Yusong Tian, Eric Drechsler, A. Di Ciaccio, Osamu Sasaki, S. George, K. Al Khoury, Abner Soffer, Jana Schaarschmidt, M. Valente, D. Fassouliotis, Trisha Farooque, Alexander Paramonov, Peter Berta, Jacqueline Batley, Sophie Trincaz-Duvoid, Kazuhiko Hara, Thomas Mathisen, Emmanuel Sauvan, Nedaa Asbah, G. Mikenberg, Giovanni Crosetti, Stefania Antonia Stucci, Giovanna Bruni, Klaus Mönig, S. De Castro, Stephen Albert Weber, Magdalena Slawinska, Shaojun Sun, Mark Kruse, Matous Vozak, A. Sbrizzi, Dennis Sperlich, Gareth Adam Bird, Filomena Sopkova, Lewis Joseph Wilkins, Ph. Schune, W-M. Yao, Alison Lister, Sebastien Rettie, K. H. Hiller, Bryan Kortman, Dale Charles Abbott, R. C. W. Henderson, Marija Glisic, Irina Antonela Cioara, Are Sivertsen Traeet, G. Lehmann Miotto, Jason Lea Oliver, Marine Kuna, Soshi Tsuno, S. L. Wu, Hamish Edward Teagle, Sara Strandberg, Tomomi Kawaguchi, Babar Ali, R.-J. Wang, Tracey Berry, Eric Schanet, Abdualazem Fadol Mohammed, Matthias Saimpert, Fabio Cerutti, R. Gupta, James David Shinner, Candice Ruth Basson, Giordon Holtsberg Stark, Daniela Salvatore, Marco Aurelio Diaz, Yumeng Cao, Tim Martin, Bernhard Matthias Flierl, Kerstin Tackmann, Olga Novgorodova, Marlon Barbero, Sicong Lu, Julien Donini, P. A. Delsart, Monika Wielers, C. F. Feng, Adam Edward Barton, D. Su, Gregory Barbour, Lars Henkelmann, Rena Wakasa, A. Tarek Abouelfadl Mohamed, Paul Tipton, Allen Mincer, Anatoly Kozhin, Ryan Justin Atkin, David Francis, Marcello Fanti, A. C. Abusleme Hoffman, Pepijn Johannes Bakker, J. Beringer, J. Walder, Jun Yan, R. F. Coelho Barrue, Jiri Hejbal, Vincent Hedberg, Vadim Bednyakov, Stefan Simion, Angelos Tsiamis, Lily Asquith, Marco Aparo, Eric Ballabene, Garabed Halladjian, Shalu Solomon, Iacopo Longarini, Victor Kukhtin, Stefan Richter, Reiyo Oishi, A. De Maria, Eric Lancon, J. Boudreau, M. Franklin, Mohamed Ouchrif, Michael R. 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Liu, Xin Wu, Abdenour Lounis, Yi Fan Hu, Rong Zhang, Jahred Adelman, Alain Bellerive, Takashi Mitani, Harry Cooke, Christian Nass, G. N. Taylor, Marco Bomben, C. L. Cheng, Nansi Andari, Lianyou Shan, Richard Nisius, Simone Sottocornola, Stergios Kazakos, Shuaiyan Kang, Melissa Ridel, Deshan Kavishka Abhayasinghe, Michael Dührssen, Henso Abreu, Arabinda Behera, Troels Petersen, Francesco Lanni, Nikolai Fomin, Benjamin Brau, Zihang Jia, Nazim Huseynov, Jaroslava Schovancova, Wenge Wang, E. Thomson, Matteo Negrini, L. Zhang, S. Rodriguez Bosca, Seppe Kuehn, R. E. Long, Christian Ohm, Nandish Arjan Gorasia, Q. Ouyang, Alice Polyxeni Morris, Xiaoxiong Wang, Ilya Korolkov, M. G. Alviggi, Peiliang Liu, Zhiqing Zhang, Balazs Konya, Xiaoguang Yue, Ben Bruers, Alicia Wongel, J. A. Valls Ferrer, Sascha Mehlhase, Marco Cristoforetti, L. Aperio Bella, Nikolaos Rompotis, Ruth Poettgen, Gregor Kramberger, Cigdem Issever, Peter Steinberg, Anatoli Romaniouk, Horst Severini, Cyril Becot, C. M. Gee, Trygve Buanes, Kevin Sedlaczek, S. Ozturk, Christopher Don Milke, J. Tanaka, Y. Hernández Jiménez, Wen-Xu Wang, Vladimir Smakhtin, J. O. Nielsen, Aviv Ruben Cukierman, Paolo Bagnaia, Apostolos Tsirigotis, Guang-Ming Zhang, D. Levin, Karsten Köneke, E. von Toerne, Rachid Mazini, Joyful Elma Mdhluli, R. J. Hawkings, J. Chen, D. Pohl, L. F. Gutierrez Zagazeta, Gabriel Alexandru Popeneciu, Marcel Vos, S. Gonzalez Fernandez, Gavin Pownall, M. C. N. Fiolhais, Chuanshun Wei, Georges Aad, Leonid Serkin, Hubert Kroha, Hong Ma, Lara Katharina Schildgen, Cheng Guang Zhu, Matt Zhang, Peter Tornambe, Jennifer Kathryn Roloff, P. J. Clark, M. Rezaei Estabragh, F. G. Diaz Capriles, J. Kroll, A. Pacheco Pages, Hidetoshi Otono, Alexandre Laurier, P. Johansson, William Trischuk, Alexandra Tudorache, Carmen Maidantchik, L. Manhaes de Andrade Filho, A. P. Pereira Peixoto, Eloisa Arena, Alexander Zaitsev, Martin Habedank, Antoine Laudrain, Hella Leonie Snoek, Jean-Francois Grivaz, Christopher Grud, Dmitriy Maximov, Trine Poulsen, P. de Jong, Christopher Samuel Pollard, Claudio Luci, Patrawan Pasuwan, Driss Benchekroun, A. Korn, Oliver Majersky, Robert Hankache, Michael William Phipps, Kunihiro Nagano, M. Sahinsoy, F. L. Castillo, I. Turk Cakir, John Rutherfoord, Florian Urs Bernlochner, Eunchong Kim, Dwayne Patrick Spiteri, Giacomo Artoni, Martin Murin, Jessica Metcalfe, Miroslav Hrabovsky, Kazunori Hanagaki, Benjamin Philip Nachman, I. Bloch, Iurii Naryshkin, Kanae Asai, Alessandro Caltabiano, A. Soloshenko, Thomas Dennis Powell, Reinhard Schwienhorst, Y. Chen, Adelina D'onofrio, Nils Gillwald, Helmut Wolters, Y-H. Chen, Ferdinand Krieter, Mateusz Dyndal, Ewelina Lobodzinska, Toshiaki Kaji, B. M. Waugh, Philipp Do Nascimento Gaspar, Ellis Fawn Kay, Claire Antel, Marcin Stolarski, David William Thomas, Nikola Makovec, Matthias Hamer, K. Bjørke, K. Zhang, Shaun Roe, S. Tzamarias, Farid Ould-Saada, Harry John Lyons, R. Iuppa, Evan Michael Carlson, Olga Rezanova, Samuel Calvet, Bryn Arthur Roberts, Charles Leggett, Fabian Huegging, N. Nishu, Alex Martyniuk, Wolfgang Wagner, Simonetta Gentile, Marie-Hélène Genest, Minghui Liu, Ivan Pogrebnyak, Matteo Franchini, Igor Aleksandrov, Ruth Magdalena Jacobs, Alessandro Lapertosa, Chen Peng, Rute Pedro, Miha Muskinja, J. B. Liu, Patrick Bauer, Benjamin John Rosser, Andrea Doria, Monica Dunford, Daniel Williams, Y. Wu, Atsuhiko Ochi, E. Fullana Torregrosa, M. E. Pozo Astigarraga, Armin Fehr, Laura Perini, Andreas Salzburger, Zachary Pollock, Martin Errenst, Stephen Haywood, S. Van Stroud, Walter Lampl, Shuangxi Wang, William Dale Heidorn, Lorenzo Rinaldi, F. Parodi, M. LeBlanc, Chris Malena Delitzsch, Thomas Paul Charman, Krzysztof Woźniak, Henri Bachacou, Daniel Fournier, David Miller, Eric Edward Corrigan, Nikiforos Nikiforou, Leonardo Carminati, Francesca Ungaro, Christopher Potter, Gabriel Stoicea, Philip Patrick Allport, Christoph Rembser, Gabriel Facini, Etienne Dreyer, Alexander Lincoln Read, Jessica Levêque, Brendon Bullard, Radu Hobincu, R. Gamboa Goni, S. Passaggio, Luiz Caloba, Henric George Wilkens, Sabina Czekierda, Michael A. Strauss, Joel Hengwei Foo, M. Kaneda, Maximiliano Sioli, Marco Delmastro, Fridolin Dittus, Yan Ke, Miao Liu, H. Arnold, G. H. A. Viehhauser, Tomas Davidek, M. Vranjes Milosavljevic, Melissa Yexley, Michael Düren, Danping Huang, Tobias Golling, Adam Bailey, Eleni Myrto Asimakopoulou, Vangelis Vladimirov, Xiaotong Chu, Peter Sherwood, Pavel Starovoitov, Bernhard Meirose, Cristiano David Sebastiani, Marianna Liberatore, Rahul Balasubramanian, M. A. B. do Vale, A. A. Affolder, Lukas Adamek, Antonio Sidoti, Ian Hinchliffe, Emily Ann Smith, Shikma Bressler, Mariya Shiyakova, Feng Lyu, and Danilo Giugni

Subjects
Quark, Physics, Particle physics, Muon, Large Hadron Collider, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, ATLAS experiment, General Physics and Astronomy, Lambda, Coupling (probability), 7. Clean energy, 01 natural sciences, 0103 physical sciences, High Energy Physics::Experiment, Invariant mass, 010306 general physics, Lepton
Abstract

A search for new phenomena is presented in final states with two leptons and one or no $b$-tagged jets. The event selection requires the two leptons to have opposite charge, the same flavor (electrons or muons), and a large invariant mass. The analysis is based on the full Run-2 proton-proton collision dataset recorded at a center-of-mass energy of $\sqrt{s} = 13$ TeV by the ATLAS experiment at the LHC, corresponding to an integrated luminosity of 139 fb$^{-1}$. No significant deviation from the expected background is observed in the data. A four-fermion contact interaction between two quarks ($b,s$) and two leptons ($ee$ or $\mu\mu$), inspired by the $B$-meson decay anomalies, is used as a benchmark signal model. This model is characterized by the energy scale and coupling, $\Lambda$ and $g_*$ respectively. Contact interactions with $\Lambda / g_*$ lower than 2.0 (2.4) TeV are excluded for electrons (muons) at the 95% confidence level, still far below the value which is favored by the $B$-meson decay anomalies. In addition, model-independent limits are set as a function of the selection on the dilepton invariant mass, which allows the results to be reinterpreted in other signal scenarios.

Published
2021

50. Sensitivity to BSM effects in the Higgs $p_T$ spectrum within SMEFT

Author

Marius Wiesemann, Michael Spira, Marco Battaglia, Massimiliano Grazzini, University of Zurich, and Grazzini, Massimiliano

Subjects
Top quark, Particle physics, Nuclear and High Energy Physics, 530 Physics, High Energy Physics::Lattice, Scalar (mathematics), FOS: Physical sciences, 10192 Physics Institute, QC770-798, Computer Science::Digital Libraries, 7. Clean energy, 01 natural sciences, Standard Model, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), Hadron-Hadron scattering (experiments), Nuclear and particle physics. Atomic energy. Radioactivity, 0103 physical sciences, Effective field theory, 3106 Nuclear and High Energy Physics, 010306 general physics, Physics, Large Hadron Collider, 010308 nuclear & particles physics, Computer Science::Information Retrieval, High Energy Physics::Phenomenology, Yukawa potential, Higgs physics, 3. Good health, Gluon, High Energy Physics - Phenomenology, Beyond Standard Model, Higgs boson, High Energy Physics::Experiment
Abstract

The study of Higgs boson production at large transverse momentum is one of the new frontiers for the LHC Higgs physics programme. This paper considers boosted Higgs production in the Standard Model Effective Field Theory (SMEFT). We focus on the gluon fusion and $t{\bar t}H$ production processes and study the effects of three dimension-6 operators: the top Yukawa operator, the gluon-Higgs effective coupling and the chromomagnetic dipole operator of the top quark. We perform a detailed study of the sensitivity of current and future LHC data to the corresponding Wilson coefficients, consistently accounting for their renormalisation group evolution. We compare the sensitivities obtained with only linear and linear + quadratic terms in the SMEFT by using the spectrum shape and the addition of the Higgs signal yields. We also consider fits of $p_T$ spectra in models with heavy-top partners and in MSSM scenarios with a light scalar top and study the validity of the SMEFT assumptions as a function of the new-particle masses and the Higgs $p_T$ range. Finally, we extract constraints on the Wilson coefficients for gluon fusion from a simultaneous fit to the ATLAS and CMS data and compare our results with those obtained in global SMEFT analyses., 39 pages, 14 figures, 1 table

Published
2021

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