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La salud mental positiva es un constructo complejo que está relacionado con el funcionamiento óptimo de la persona. Comprende un conjunto de cualidades orientadas al desarrollo del potencial del individuo. La Escala de Salud Mental Positiva es uno de los instrumentos más utilizados para evaluarlo, sin embargo, los antecedentes señalan inconsistencias respecto a su estructura interna. El objetivo del presente estudio fue analizar las propiedades psicométricas de la Escala de Salud Mental Positiva en Arequipa-Perú. Participaron 3933 personas, 50.3% fueron mujeres y 49.7% fueron varones, incluyendo desde adolescentes hasta adultos mayores. La evaluación mediante AFC de la estructura original evidenció índices de ajuste pobres, por lo que se tuvo que evaluar la dimensionalidad y proponer una nueva estructura. Para lo cual, se dividió a la muestra (n1 = 1966 y n2 = 1967). En la primera, se aplicó un AFE y en la segunda se valida mediante un AFC. Se hallaron tres factores y se concluye que tiene un buen ajuste (χ2(431) = 2473.378; CFI = .959; TLI = .956, RMSEA = .049; SRMR = .051). La consistencia interna mostró valores mayores a .81. Finalmente, se evaluó la equivalencia de la medición según el sexo, hallando que el instrumento presenta invarianza de la medición. Positive mental health is a complex construct that is related to the optimal functioning of the person. It comprises a set of qualities aimed at the development of the individual's potential. The Positive Mental Health Scale is one of the most used instruments to evaluate it, however, the antecedents indicate inconsistencies regarding its internal structure. The objective of this study was to analyze the psychometric properties of the Positive Mental Health Scale in Arequipa-Peru. 3,933 people participated, 50.3% were women and 49.7% were men, including from adolescents to the elderly. The evaluation by CFA of the original structure showed poor fit indices, so the dimensionality had to be evaluated and a new structure had to be proposed. For which the sample is divided (n1 = 1,966 and n2 = 1,967). In the first, an EFA was applied and in the second, it is validated by means of a CFA. Three factors were found and it is concluded that it has a good fit (χ2 (431) = 2,473.378; CFI = .959; TLI = .956, RMSEA = .049; SRMR = .051). The internal consistency showed values ​​greater than .81. Finally, the equivalence of the measurement according to sex was evaluated, finding that the instrument presents measurement invariance.

Background: The COVID-19 pandemic has had a great impact on cognitive health in Latin American older adults, increasing the risk of cognitive impairment and dementia. Our objective was to analyze the prevalence of dementia and the associated factors in Latin American older adults during SARS-CoV-2 pandemic. Methods: A multicentric first phase cross-sectional observational study was conducted during the SARS-CoV-2 pandemic. Five thousand two hundred and forty-five Latin American adults over 60 years of age were studied in 10 countries: Argentina, Bolivia, Chile, Colombia, Ecuador, Guatemala, Mexico, Peru, the Dominican Republic, and Venezuela. We used the telephone version of Montreal Cognitive Assessment, the “Alzheimer Disease 8” scale for functional and cognitive changes, and the abbreviated version of the Yesavage depression scale. We also asked for sociodemographic and lockdown data. All the evaluation was made by telephone. Cross-tabulations and χ2 tests were used to determine the variability of the prevalence of impairment by sociodemographic characteristics and binary logistic regression to assess the association between dementia and sociodemographic factors. Results: We observed that the prevalence of dementia in Latin America is 15.6%, varying depending on the country (Argentine = 7.83 and Bolivia = 28.5%). The variables most associated with dementia were race and age. It does not seem to be associated with the pandemic but with social and socio-health factors. Conclusion: The prevalence of dementia shows a significant increase in Latin America, attributable to a constellation of ethnic, demographic, and socioeconomic factors.

The preclinical stages of dementia include subtle neurocognitive changes that are not easily detected in standard clinical evaluations. Neuropsychological evaluation is important for the classification and prediction of deterioration in all the phases of dementia. Objective: Compare the neuropsychological performance in healthy older adults with subjective cognitive decline (SCD) and with mild cognitive impairment (MCI) using principal components analysis. Methods: We evaluated 94 older adults with a clinical protocol which included general measures of mental, emotional and functional state. The neuropsychological protocol included tasks of memory, executive function, attention, verbal fluency and visuoconstructional abilities. We used principal component analysis (PCA) to reduce variables´ dimensionality on neuropsychological evaluation. Results: 33(35%) participants had a normal cognitive function, 35(37%) had subjective cognitive decline and 26(28%) had a mild cognitive impairment. The PCA showed seven factors: processing speed, memory, visuoconstruction, verbal fluency and executive components of cognitive flexibility, inhibitory control and working memory. ANOVA had shown significant differences between the groups in the memory (F=4.383, p=0.016, η2p=0.087) and visuoconstructional components (F=5.395, p=0.006, η2p=0.105). Post hoc analysis revealed lower memory scores in MCI than SCD participants and in visuospatial abilities between MCI and SCD and MCI and Normal participants. Conclusions: We observed differentiated cognitive profiles among the participants in memory and visuoconstruction components. The use of PCA in the neuropsychological evaluation could help to make a differentiation of cognitive abilities in preclinical stages of dementia. RESUMO. Os estágios pré-clínicos da demência incluem mudanças neurocognitivas sutis que não são facilmente detectadas nas avaliações clínicas padrão. A avaliação neuropsicológica é importante para a classificação e predição da deterioração em todas as fases da demência. Objetivo: Comparar o desempenho neuropsicológico em idosos saudáveis com declínio cognitivo subjetivo (DCS) e com comprometimento cognitivo leve (CCL) por meio da análise de componentes principais. Métodos: Avaliaram-se 94 idosos com um protocolo clínico que incluía medidas gerais do estado mental, emocional e funcional. O protocolo neuropsicológico incluiu tarefas de memória, função executiva, atenção, fluência verbal e habilidades visuoconstrutivas. Utilizou-se a análise de componentes principais (PCA, na sigla em inglês) para reduzir a dimensionalidade das variáveis na avaliação neuropsicológica. Resultados: Um total de 33 (35%) participantes apresentavam função cognitiva normal, 35 (37%) declínio cognitivo subjetivo e 26 (28%) comprometimento cognitivo leve. A PCA apresentou sete fatores: velocidade de processamento, memória, visuoconstrução, fluência verbal e componentes executivos de flexibilidade cognitiva, controle inibitório e memória de trabalho. ANOVA mostrou diferenças significativas entre os grupos na memória (F=4,383, p=0,016, η2p=0,087) e componentes visuoconstrutivos (F=5,395, p=0,006, η2p=0,105). A análise post hoc revelou escores de memória mais baixos no CCL do que os participantes com DCS e nas habilidades visuoespaciais entre CCL e DCS e CCL e participantes normais. Conclusões: Observaram-se perfis cognitivos diferenciados entre os participantes nos componentes de memória e visuoconstrução. O uso da PCA na avaliação neuropsicológica poderia auxiliar na diferenciação das habilidades cognitivas em estágios pré-clínicos da demência.

Nos propusimos comparar el rendimiento en tareas de función ejecutiva entre adolescentes y adultos mayores bilingües y monolingües. Utilizamos un diseño comparativo transversal. Evaluamos a 48 personas monolingües (24 adolescentes y 24 adultos mayores) y 56 bilingües (31 adolescentes y 25 adultos mayores) con una amplia batería neuropsicológica que comprendían tareas de flexibilidad cognitiva (Wisconsin Card Sorting Test), control inhibitorio (test de Stroop), memoria de trabajo (subescalas de Retención de dígitos, Secuencia de números y letras: test Wechsler de inteligencia) y acceso a la memoria a largo plazo (fluidez semántica y fonológica). Nuestros resultados indican que los adolescentes y adultos mayores monolingües rinden mejor en las pruebas de control ejecutivo que sus pares bilingües, siendo estas diferencias menores en los adultos mayores y no parecen asociarse a la edad y a la frecuencia de uso de L1 (castellano) y L2 (quechua). Estos resultados muestran que durante la adolescencia hay una desventaja a nivel ejecutivo en las personas bilingües, la cual parece disminuir en la adultez. Se discuten los resultados a la luz del peso de los factores socioculturales y a la posibilidad de entender al bilingüismo como un mecanismo ligado a la reserva cognitiva.

Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF. Fil: Parra, Mario Alfredo. Universidad Autónoma del Caribe; Colombia Fil: Baez, Sandra. Universidad de los Andes; Colombia Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gonzalez Campo, Cecilia. Universidad de San Andrés; Argentina Fil: Santamaría García, Hernando. Pontificia Universidad Javeriana; Colombia Fil: Aprahamian, Ivan. No especifíca; Fil: Bertolucci, Paulo. Universidade Federal de Sao Paulo; Brasil Fil: Bustin, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina Fil: Camargos Bicalho, Maria Aparecida. Universidade Federal de Minas Gerais; Brasil Fil: Cano Gutierrez, Carlos. Hospital Universitario San Ignacio; Colombia Fil: Caramelli, Paulo. Universidade Federal de Minas Gerais; Brasil Fil: Chaves, Marcia L. F.. Universidade Federal do Rio Grande do Sul; Brasil Fil: Perez Cogram, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina Fil: Beber, Bárbara Costa. Universidade Federal do Rio Grande do Sul; Brasil Fil: Court, Felipe A.. Universidad Mayor; Chile Fil: de Souza, Leonardo Cruz. Universidade Federal de Minas Gerais; Brasil Fil: Custodio, Nilton. Peruvian Institute of Neurosciences; Perú Fil: Damian, Andres. Universidad de la República; Uruguay Fil: de la Cruz, Myriam. University of California; Estados Unidos Fil: Diehl Rodriguez, Roberta. Universidade de Sao Paulo; Brasil Fil: Dozzi Brucki, Sonia Maria. Universidade de Sao Paulo; Brasil Fil: Fajersztajn, Lais. Universidade de Sao Paulo; Brasil Fil: Farías, Gonzalo A.. Universidad de Chile; Chile Fil: De Felice, Fernanda G.. Universidade Federal do Rio de Janeiro; Brasil Fil: Ferrari, Raffaele. Colegio Universitario de Londres; Reino Unido Fil: Ferreira de Oliveira, Fabricio. Universidade de Sao Paulo; Brasil Fil: Ferreira, Sergio Teixeira. Universidade Federal do Rio de Janeiro; Brasil Fil: Ferretti, Ceres. Universidade de Sao Paulo; Brasil Fil: Figueredo Balthazar, Marcio Luiz. Universidade Estadual de Campinas; Brasil Fil: Ferreira Frota, Norberto Anizio. Universidade de Fortaleza; Brasil Fil: Fuentes, Patricio. No especifíca; Fil: García, Adolfo Martín. Universidad Nacional de Cuyo; Argentina. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Garcia, Patricia J.. Cayetano Heredia University; Perú Fil: de Gobbi Porto, Fábio Henrique. Universidade de Sao Paulo; Brasil Fil: Duque Peñailillo, Lissette. Ecuadorian Dementia Association; Ecuador Fil: Engler, Henry Willy. Universidad de la República; Uruguay Fil: Maier, Irene. Universidad de Chile; Chile Fil: Mata, Ignacio F.. University of Pittsburgh; Estados Unidos Fil: González Billault, Christian. Universidad de Chile; Chile Fil: Lopez, Oscar L.. University of Pittsburgh; Estados Unidos Fil: Morelli, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Nitrini, Ricardo. Universidade de Sao Paulo; Brasil Fil: Quiroz, Yakeel T.. Harvard Medical School; Estados Unidos Fil: Guerrero Barragan, Alejandra. Universidad de la Sabana; Colombia Fil: Huepe, David. Universidad Adolfo Ibañez; Chile Fil: Pio, Fabricio Joao. Hospital Governador Celso Ramos; Brasil Fil: Suemoto, Claudia Kimie. Universidade de Sao Paulo; Brasil Fil: Kochhann, Renata. Pontificia Universidade Católica do Rio Grande do Sul; Brasil Fil: Kochen, Sara Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina Fil: Kumfor, Fiona. University of Western Sydney; Australia Fil: Lanata, Serggio. University of California; Estados Unidos Fil: Miller, Bruce. University of California; Estados Unidos Fil: Lessa Mansur, Leticia. Universidade de Sao Paulo; Brasil Fil: Lie Hosogi, Mirna. Universidade de Sao Paulo; Brasil Fil: Lillo, Patricia. Universidad de Chile; Chile Fil: Llibre Guerra, Jorge. University of California; Estados Unidos Fil: Lira, David. Peruvian Institute of Neurosciences; Perú Fil: Lopera, Francisco. Universidad de Antioquia; Colombia Fil: Comas, Adelina. No especifíca; Fil: Avila Funes, José Alberto. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; México Fil: Sosa, Ana Luisa. Instituto Nacional de Neurología y Neurocirugía; México Fil: Ramos, Claudia. University of California; Estados Unidos Fil: de Paula França Resende, Elisa. University of California; Estados Unidos Fil: Snyder, Heather M.. No especifíca; Fil: Tarnanas, Ioannis. University of California; Estados Unidos Fil: Yokoyama, Jenifer. University of California; Estados Unidos Fil: Llibre, Juan. Centro de Estudios de Alzheimer; Cuba Fil: Cardona Londoño, Juan Felipe. Universidad del Valle; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Possin, Kate. University of California; Estados Unidos Fil: Kosik, Kenneth. University of California; Estados Unidos Fil: Montesinos, Rosa. Peruvian Institute of Neurosciences; Perú Fil: Moguilner, Sebastian Gabriel. University of California; Estados Unidos Fil: Solis, Patricia Cristina Lourdes. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina. Universidad Nacional Arturo Jauretche; Argentina. Universidad de Buenos Aires; Argentina Fil: de Lucena Ferretti Rebustini, Renata Eloah. Universidade de Sao Paulo; Brasil Fil: Ramirez, Jeronimo Martin. No especifíca; Fil: Matallana, Diana. Pontificia Universidad Javeriana; Colombia Fil: Mbakile Mahlanza, Lingani. University of California; Estados Unidos Fil: Mendonça Marques Ton, Alyne. Universidade Federal do Rio de Janeiro; Brasil Fil: Melo Tavares, Ronnielly. Centro Universitario de Belo Horizonte.; Brasil Fil: Miotto, Eliane C.. Universidade de Sao Paulo; Brasil Fil: Muniz-Terrera, Graciela. University of Edinburgh; Reino Unido Fil: MuñozN evárez, Luis Arnoldo. University of California; Estados Unidos Fil: Orozco, David. Universidad Nacional del Sur; Argentina Fil: Okada de Oliveira, Maira. University of California; Estados Unidos Fil: Piguet, Olivier. University of Western Sydney; Australia Fil: Pintado Caipa, Maritza. University of California; Estados Unidos Fil: Piña Escudero, Stefanie Danielle. University of California; Estados Unidos Fil: Porcello Schilling, Lucas. Pontificia Universidade Católica do Rio Grande do Sul; Brasil Fil: Rodrigues Palmeira, André Luiz. Hospital Ernesto Dornelles; Brasil Fil: Sanches Yassuda, Mônica. Universidade de Sao Paulo; Brasil Fil: Santacruz Escudero, Jose Manuel. Pontificia Universidad Javeriana; Colombia Fil: Serafim, Rodrigo Bernardo. Universidade Federal do Rio de Janeiro; Brasil Fil: Smid, Jerusa. Universidade de Sao Paulo; Brasil Fil: Slachevsky, Andrea. Universidad de Chile; Chile Fil: Serrano, Cecilia Mariela. No especifíca; Fil: Soto Añari, Marcio. Universidad Católica San Pablo; Perú Fil: Takada, Leonel Tadao. Universidade de Sao Paulo; Brasil Fil: Tenenholz Grinberg, Lea. Universidade de Sao Paulo; Brasil Fil: Teixeira, Antonio Lucio. Universidade Federal de Minas Gerais; Brasil Fil: Tonidandel Barbosa, Maira. Universidade Federal de Minas Gerais; Brasil Fil: Trépel, Dominic. Trinity College; Estados Unidos Fil: Ibañez, Agustin Mariano. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

Estudios recientes muestran que una alta prevalencia de trastornos psicóticos y por consumo de sustancias comparten mecanismos cerebrales comunes que pueden afectar el rendimiento cognitivo, la adhesión al tratamiento y, con ello, aumentar el riesgo de recaídas. Objetivo: Comparar el rendimiento cognitivo en pacientes con alcoholismo y con esquizofrenia. Material y Métodos: Estudio observacional que evaluó a 18 pacientes con esquizofrenia y 32 con trastorno mental debido a consumo de alcohol. Se utilizó la batería neuropsicológica breve NEUROPSI, validada en español. Resultados: Se encontraron diferencias significativas entre ambos grupos en áreas de función ejecutiva y memoria declarativa (a largo plazo), con mayores puntajes de deterioro en el grupo de pacientes con esquizofrenia. Conclusiones: Los resultados permiten comprender y explicar las dificultades observadas en pacientes con esquizofrenia en cuanto a funciones de regulación conductual y recuperación de información.

Intellectual Property is a powerful legal and economic instrument. In our “knowledge economy”, patents are the preferred IP tool with special emphasis in the pharma – agro biotech industry. However, the growth of patents in the bio sector such as the pharma and agro fields, encounters many challenges. Life itself has not been defined yet. So, how can it be determined exactly when a living being, or a biological entity has been modified by itself or by human intervention, and thus address issues of patentability? Therefore, a researcher in the bio field cannot be alien to Intellectual Property, being the main actor in the revolution of the bio-pharma-agro sectors.

Fibromyalgia (FMS) is a chronic condition that encompasses widespread pain associated with cognitive impairment and significant emotional distress related to functional disability that affects mainly women. However, the mechanisms underlying the origin of the cognitive impairments and how the current COVID-19 pandemic impacts remain elusive. This study aimed to determine whether there is an association between cognitive performance in executive functions, physical pain, and psychological distress caused by the pandemic in a group of Chilean women with FMS using a novel online protocol of neuropsychological evaluation. We found that women with FMS present cognitive impairment predominantly explained by pain and anxiety symptoms, which are associated with the difficulties experienced from the COVID-19 pandemic. These results point out the importance of considering a broader perspective for treatment, including anxiety symptoms and the psychological distress caused by the pandemic as a therapeutic target for cognitive impairments.

Introduction: Early-life educational experiences are associated with cognitive performance in aging. Early literacy seems to improve executive control mechanisms, however, it is not clear whether early education would still be an advantage in countries like Peru, where access to and quality of education is highly variable.Aim: Our objective was to analyze the association of literacy level with executive control factors.Method: We evaluated 93 healthy older adults with a clinical protocol that included the Mini-Mental State Examination, the Geriatric Depression Scale and Global Dementia Staging. We also used a neuropsychological executive function battery which included the Trail-Making Test parts A and B, the Stroop Test, phonological and semantic verbal fluency tasks, Forward and Backward Digits, Numbers and Letters of the Wechsler Scale, and the Go/No-Go task. We used a principal component analysis for the dimensional reduction of the variables. To measure the level of literacy we used the word accentuation test (WAT).Results: We observed statistically significant correlations between the principal components (PCs) of working memory, cognitive flexibility and inhibitory control with the WAT scores. Furthermore, we observed that processing speed and WAT predict the scores on PCs factors better than years of education and age.Conclusions: Literacy level correlates more closely with better cognitive performance than years of education and thus, might improve executive control factors that could compensate and protect against brain changes in cognitive decline and dementia.

The COVID-19 pandemic has shown the need for neuropsychological care for older adults with memory complaints in different contexts, including rural areas or areas with difficult access.This study aimed to analyze the clinical utility of the Phototest, through telemedicine, to identify mild cognitive impairment in rural older adults with memory complaints, during the COVID-19 pandemic.We performed a cross-sectional, case-control, and clinical utility comparison of brief cognitive tests (BCTs). The sample included 111 rural elderly people with mild cognitive impairment (MCI) and 130 healthy controls from the Los Lagos region, Chile. The instruments adopted were modified Mini-Mental State Examination (MMSEm) and adapted version of the Phototest (PT) for Chile.To identify mild cognitive impairment, using a cutoff score of 27-28 points, the Phototest showed a sensitivity of 96.6% and a specificity of 81.8%; indicators superior to those of the MMSEm.The Phototest is more accurate than the MMSEm in identifying cognitive alterations in rural older adults with cognitive memory complaints through telemedicine. Therefore, its use in primary care is recommended in order to perform early detection of preclinical cognitive alterations in mild cognitive impairment or neurodegenerative diseases.A pandemia de COVID-19 mostrou a necessidade de cuidados neuropsicológicos para adultos idosos com queixas de memória em diferentes contextos, incluindo áreas rurais ou áreas de difícil acesso.Analisar a utilidade clínica do Phototest, por meio da telemedicina, para identificar uma leve deficiência cognitiva em adultos idosos rurais com queixas de memória, durante a pandemia de COVID-19.Realizamos uma comparação transversal, caso-controle e utilidade clínica dos testes cognitivos breves. Amostra: Cento e onze idosos rurais com deficiência cognitiva leve (DCL) e 130 controles saudáveis da região de Los Lagos, Chile. Instrumentos: Minimental modificado (MMSEm) e versão do teste fotográfico (PT) adaptada para o Chile.Para identificar a DCL, usando pontuação de corte de 27-28 pontos, o Phototest mostrou sensibilidade de 96,6% e especificidade de 81,8%; indicadores superiores aos do MMSEm.O Phototest é mais preciso que o MMSEm para identificar, por meio da telemedicina, alterações cognitivas em adultos idosos rurais com queixas de memória cognitiva. Sendo assim, seu uso na atenção primária é recomendado para realizar a detecção precoce de alterações cognitivas pré-clínicas em DCL ou doenças neurodegenerativas.

Introducción La detección de síntomas de ansiedad entre el personal sanitario que atiende a pacientes contagiados de COVID-19 es una prioridad actual. Se requieren instrumentos rápidos y válidos para esta población. El objetivo es establecer la validez de constructo y la confiabilidad de la Escala de Ansiedad Generalizada (GAD-7) en médicos colombianos durante la cuarentena por la COVID-19. Métodos Estudio eSalud, en el que se recopilaron datos transversales en línea (n = 1.030) de 610 médicos de COVID y 420 no de COVID durante la cuarentena colombiana, entre el 20 de abril y el 10 de agosto de 2020. Se contactó con cada sujeto, que confirmó participación, identidad y función profesional. Resultados Se encontró una estructura factorial de 1 solo factor, conformado por los 7 ítems del instrumento, que logró explicar el 70% de la varianza. Los índices de bondad de ajuste (RMSEA = 0,080; CFI = 0,995; SRMR = 0,053; p 0,07. Por último, la consistencia interna del instrumento fue buena, con alfa de Cronbach = 0,920 (IC95%, 8,80-9,71). Conclusiones El GAD-7 es un instrumento que presenta indicadores adecuados de validez y confiabilidad. Es un excelente instrumento, confiable, fácil y rápido de usar para la detección de los síntomas de ansiedad generalizada en personal médico, atienda o no a pacientes contagiados de COVID-19.

Introduction Epilepsy is a chronic neurological disorder that may occur alongside cognitive changes, with effects on multiple cognitive domains. Objective To compare the cognitive performance of patients with epilepsy and healthy controls through Montreal Cognitive Assessment (MoCA) during outpatient consultation at a reference diagnostic center in Colombia and analyze and the influencing factors. Materials and methodology One-hundred and four patients during neurology outpatient consultation in the city of Cartagena, Colombia, were assessed with the (MoCA) test, i.e., 54 people who consulted for headache and have not been diagnosed with epilepsy (NEP) and 50 with a diagnosis of epilepsy (EPs) according to the diagnostic criteria of the International League Against Epilepsy (ILAE). Results Significant differences were found in the total mean scores of the (MoCA) between (EPs) and (NPE) groups (t = 4.72; p

Resumen El presente estudio reporta la información normativa y psicométrica del DOT (forma A y B), una medida breve de organización perceptual-visual relevante para la investigación aplicada y la práctica clínica. Participó una muestra efectiva de 775 adultos universitarios, de Lima (Perú). La administración del test se hizo en grupo, con instrucciones estandarizadas. Se halló que la confiabilidad test-retest era moderadamente alta; la covariación con una prueba de inteligencia fluida fue pequeña, pero teóricamente consistente. La información clínico-métrica sobre el error de medición y el cambio confiable fue adecuada (mínimo cambio detectable). Las diferencias intra-grupos y entre-grupos (muestra americana) revelaron patrones de resultados esencialmente consistentes, detectándose un efecto de la práctica comparativamente mayor en la muestra peruana. Se discuten las implicaciones de los resultados. Abstract The present study reports the normative and psychometric information of DOT (form A and B), a brief measure of visuospatial organization relevant to applied research and clinical practice. A sample of 775 university adults participated, from Lima (Peru). The administration of the test was done in groups, with standardized instructions. We found moderately high test-retest reliability; and the covariation with a fluid intelligence test was small but theoretically consistent. The clinimetrics of the measurement error and the reliable change was adequate (minimum detectable change). The intra-group and between-group (American sample) differences revealed patterns of essentially consistent results, detecting a comparatively greater effect of practice in the Peruvian sample. The implications of the results are discussed. Resumo O estudo apresenta a informação normativa e psicométrica do DOT (formas A e B), uma medida breve da capacidade de organização perceptual-visual relevante para a pesquisa aplicada e para a prática clínica. Participou uma amostra efetiva de 775 adultos universitários de Lima (Peru). A administração do teste foi feita em grupos, com instruções padronizadas. Os resultados amostram uma confiabilidade teste-reteste moderadamente alta; a covariação com um teste de inteligência fluida foi pequena, mas teoricamente consistente. As informações clínicas sobre o erro de medição e a mudança confiável foram adequadas (mudança mínima detectável). As diferenças intragrupos e entre grupos (amostra americana) revelaram padrões de resultados essencialmente consistentes, detectando-se um efeito comparativamente maior da prática na amostra peruana. As implicações dos resultados são discutidas. Résumé La présente étude rapporte les informations normatives et psychométriques du DOT (formulaires A et B), une brève mesure de l’organisation capacité visuospatiale pertinente pour la recherche appliquée et la pratique clinique. Un échantillon effectif de 775 adultes universitaires ont participé, de Lima (Pérou). L’administration du test a été effectuée en groupes, avec des instructions normalisées. Nous avons constaté que la fiabilité test-retest était relativement élevée; la covariation avec un test d’intelligence fluide était petite mais théoriquement cohérente. Les informations clinométriques sur l’erreur de mesure et le changement fiable étaient adéquates (changement minimum détectable). Les différences entre groupes et entre groupes (échantillon américain) ont révélé des tendances de résultats essentiellement cohérents, détectant un effet comparativement plus important de la pratique dans l’échantillon péruvien. Les implications des résultats sont discutées.

The present study reports the normative and psychometric information of DOT (form A and B), a brief measure of visuospatial organization relevant to applied research and clinical practice. A sample of 775 university adults participated, from Lima (Peru). The administra-tion of the test was done in groups, with standardized instructions. We found moderately high test-retest reliability; and the covariation with a fluid intelligence test was small but the-oretically consistent. The clinimetrics of the measurement error and the reliable change was adequate (minimum detectable change). The intra-group and between-group (American sample) differences revealed patterns of essentially consistent results, detecting a compara-tively greater effect of practice in the Peruvian sample. The implications of the results are discussed. El presente estudio reporta la información normativa y psicométrica del DOT (forma A y B), una medida breve de organización perceptual-visual relevante para la investigación aplicada y la práctica clínica. Participó una muestra efectiva de 775 adultos universitarios, de Lima (Perú). La administración del test se hizo en grupo, con instrucciones estandarizadas. Se halló que la confiabilidad test-retest era moderadamente alta; la covariación con una prueba de inteligencia fluida fue pequeña, pero teóricamente consistente. La información clínico-métrica sobre el error de medición y el cambio confiable fue adecuada (mínimo cambio detectable). Las diferencias intra-grupos y entre-grupos (muestra americana) revelaron patrones de resultados esencialmente consistentes, detectándose un efecto de la práctica comparativamente mayor en la muestra peruana. Se discuten las implicaciones de los resultados. La présente étude rapporte les informations normatives et psychométriques du DOT (formulaires A et B), une brève mesure de l’organisation capacité visuospatiale pertinente pour la recherche appliquée et la pratique clinique. Un échantillon effectif de 775 adultes universitaires ont participé, de Lima (Pérou). L’administration du test a été effectuée en groupes, avec des instructions normalisées. Nous avons constaté que la fiabilité test-retest était relativement élevée; la covariation avec un test d’intelligence fluide était petite mais théoriquement cohérente. Les informations clinométriques sur l’erreur de mesure et le chan-gement fiable étaient adéquates (changement minimum détectable). Les différences entre groupes et entre groupes (échantillon américain) ont révélé des tendances de résultats essen-tiellement cohérents, détectant un effet comparativement plus important de la pratique dans l’échantillon péruvien. Les implications des résultats sont discutées. O estudo apresenta a informação normativa e psicométrica do DOT (formas A e B), uma medida breve da capacidade de organização perceptual-visual relevante para a pesquisa apli-cada e para a prática clínica. Participou uma amostra efetiva de 775 adultos universitários de Lima (Peru). A administração do teste foi feita em grupos, com instruções padronizadas. Os resultados amostram uma confiabilidade teste-reteste moderadamente alta; a covariação com um teste de inteligência fluida foi pequena, mas teoricamente consistente. As infor-mações clínicas sobre o erro de medição e a mudança confiável foram adequadas (mudança mínima detectável). As diferenças intragrupos e entre grupos (amostra americana) revelaram padrões de resultados essencialmente consistentes, detectando-se um efeito comparativa-mente maior da prática na amostra peruana. As implicações dos resultados são discutidas.

In Latin America, the volume of care of infected patients, higher presence of comorbidities among older adults, and restricted access to clinical controls have become this age group into one with the highest risk (Dubey etal , 2020) [ ]a Consortium of universities, research centers, and clinical centers have joined forces to carry out research which seeks to know the emotional state of Latin American older adults during confinement by Coronavirus disease (COVID-19) The protocol we used includes a sociodemographic and clinical questionnaire, information on confinement, lifestyles, and the abbreviated version of the Yesavage Geriatric Depression Scale (Martinez de la Iglesia etal , 2020)

Objective To generate normative data for the Rey-Osterrieth Complex Figure (ROCF) in Spanish-speaking pediatric populations. Method The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the ROCF as part of a larger neuropsychological battery. The ROCF copy and immediate recall (3 minutes) scores were normed using multiple linear regressions and standard deviations of residual values. Age, age2, sex, and mean level of parental education (MLPE) were included as predictors in the analyses. Results The final multiple linear regression models showed main effect for age on copy and immediate recall scores, such that scores increased linearly as a function of age. Age2 affected ROCF copy score for all countries, except Puerto Rico; and ROCF immediate recall scores for all countries, except Chile, Guatemala, Honduras, Paraguay, and Puerto Rico. Models indicated that children whose parent(s) had a MLPE >12 years obtained higher scores compared to children whose parent(s) had a MLPE≤12 years for Chile, Puerto Rico, and Spain in the ROCF copy, and Paraguay and Spain for the ROCF immediate recall. Sex affected ROCF copy and immediate recall score for Chile and Puerto Rico with girls scoring higher than boys. Conclusions This is the largest Spanish-speaking pediatric normative study in the world, and it will allow neuropsychologists from these countries to have a more accurate approach to interpret the ROCF Test in pediatric populations.

To determine the prevalence of low scores on two neuropsychological tests commonly used to evaluate learning and memory in children. 6,030 healthy children from 10 countries in Latin America and Spain were administered Rey–Osterrieth Complex Figure (ROCF) and the Test de Aprendizaje y Memoria Verbal–Infantil (TAMV-I). Results showed that low scores are common when multiple neuropsychological outcomes (tests and/or scores) are evaluated in healthy individuals. Clinicians should consider the higher probability of low scores in a given individual when evaluating learning and memory using various sets of scores to reduce false-positive diagnoses of cognitive deficits in pediatric populations.

Resumen El uso combinado de actividad cognitiva (AC) y actividad fisica (AF) parece modular los factores asociados a la incidencia de Alzheimer leve. Objetivos Examinar los efectos de una intervencion combinada de AC y AF sobre el rendimiento cognitivo en ancianos con EA leve. Metodo Diseno cuasiexperimental con asignacion aleatoria al grupo de intervencion y grupo control. Participantes Ochenta sujetos ≥ 60 anos con diagnostico neurologico de demencia tipo Alzheimer de grado leve, de los cuales 60 concluyeron el estudio (19 hombres y 41 mujeres). Los participantes fueron divididos de forma aleatoria en un grupo de intervencion (GI: n = 24, M ± DE 71,8 ± 5,5 anos) sometido a un programa combinado de entrenamiento cognitivo y actividad fisica de 6 meses de duracion y un grupo control (GC: n = 36) integrado por sujetos sedentarios (M ± DE 73,8 ± 6,3 anos) que no realizaron actividad fisica ni estuvieron sometidos a entrenamiento cognitivo durante el estudio. Resultados La t de Student inter e intragrupal reporto diferencias significativas en MMSE, TFCR, TAAVR y TMT-A y B a favor del GI, mostrando un incremento en las medias de desempeno de todas las dimensiones evaluadas despues del programa de AF y AC, respecto del GC. El ANCOVA reporto evidencia a favor del impacto de la AC y la AF en la funcion cognitiva del GI vs. controles (f = 17,378; p Conclusiones Se encontraron resultados favorables que muestran una diferencia significativa en los grupos de estudio, revelando como la AC y AF mejora el desempeno cognitivo de los ancianos con demencia.

Objective To generate normative data for the Stroop Word-Color Interference test in Spanish-speaking pediatric populations. Method The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the Stroop Word-Color Interference test as part of a larger neuropsychological battery. The Stroop Word, Stroop Color, Stroop Word-Color, and Stroop Interference scores were normed using multiple linear regressions and standard deviations of residual values. Age, age2, sex, and mean level of parental education (MLPE) were included as predictors in the analyses. Results The final multiple linear regression models showed main effects for age on all scores, except on Stroop Interference for Guatemala, such that scores increased linearly as a function of age. Age2 affected Stroop Word scores for all countries, Stroop Color scores for Ecuador, Mexico, Peru, and Spain; Stroop Word-Color scores for Ecuador, Mexico, and Paraguay; and Stroop Interference scores for Cuba, Guatemala, and Spain. MLPE affected Stroop Word scores for Chile, Mexico, and Puerto Rico; Stroop Color scores for Mexico, Puerto Rico, and Spain; Stroop Word-Color scores for Ecuador, Guatemala, Mexico, Puerto Rico and Spain; and Stroop-Interference scores for Ecuador, Mexico, and Spain. Sex affected Stroop Word scores for Spain, Stroop Color scores for Mexico, and Stroop Interference for Honduras. Conclusions This is the largest Spanish-speaking pediatric normative study in the world, and it will allow neuropsychologists from these countries to have a more accurate approach to interpret the Stroop Word-Color Interference test in pediatric populations.

OBJECTIVE: To generate normative data for the Modified Wisconsin Card Sorting Test (M-WCST) in Spanish-speaking pediatric populations. METHOD: The sample consisted of 4,373 healthy children from nine countries in Latin America (Chile, Cuba, Ecuador, Guatemala, Honduras, Mexico, Paraguay, Peru, and Puerto Rico) and Spain. Each participant was administered the M-WCST as part of a larger neuropsychological battery. Number of categories, perseverative errors, and total error scores were normed using multiple linear regressions and standard deviations of residual values. Age, age2, sex, and mean level of parental education (MLPE) were included as predictors in the analyses. RESULTS: The final multiple linear regression models indicated main effects for age on all scores, such that the number of categories correct increased and total number of perseverative errors and total number of errors decrease linearly as a function of age. Age2 had a significant effect in Chile, Cuba, Ecuador, and Spain for numbers of categories; a significant effect for number of perseverative errors in Chile, Cuba, Mexico, and Spain; and a significant effect for number of total errors in Chile, Cuba, Peru, and Spain. Models showed an effect for MLPE in Cuba (total errors), Ecuador (categories and total errors), Mexico (all scores), Paraguay (perseverative errors and total error), and Spain (categories and total errors). Sex affected number of total errors for Ecuador. CONCLUSIONS: This is the largest Spanish-speaking pediatric normative study in the world, and it will allow neuropsychologists from these countries to have a more accurate way to interpret the M-WCST with pediatric populations.

The study of cognitive functions in ageing, especially the executive functions in illiterate populations have not received the necessary attention. Studies show a significant increase of risk to develop cognitive impairment or dementia in populations with low level of education and/or illiterate. This increase of cases would be associated with the low capacity of brain and cognition to cope with neurodegenerative processes and which would be mediated by formal educational process. The aim of the study is compare the performance in executive functions in literate and illiterates. A total of 156 older adults were divided into four groups according to educational level: illiterates; subjects with basic and high school and subjects with university degree with the frontal assessment battery (FAB). Our results show significant differences between literates and illiterates in those variables mediated by verbal aspects and inhibitory control mechanisms. We also note that illiterate subjects and with basic school level are significantly different from subjects with higher school level and with university education. These first approximations show us the importance that formal schooling has on brain and functional architecture and opens up a line of promising research that analyzes the role of the executive function in normal and pathological cognitive ageing.