Search

Your search keyword '"Marciante, K. (Kristin)"' showing total 9 results
Start Over Author "Marciante, K. (Kristin)"
9 results on '"Marciante, K. (Kristin)"'

1. Genetic variants in RBFOX3 are associated with sleep latency

Author

Amin, N. (Najaf), Allebrandt, K.V., Spek, A. (Ashley) van der, Müller-Myhsok, B. (B.), Hek, K. (Karin), Teder-Laving, M. (Maris), Hayward, C. (Caroline), Esko, T. (Tõnu), Mill, J. van, Mbarek, H., Watson, N.F. (Nathaniel F), Melville, S.A. (Scott), Del Greco, F.M. (Fabiola), Byrne, E.M. (Enda), Oole, E. (Edwin), Kolcic, I. (Ivana), Chen, T.H., Evans, D.S. (Daniel), Coresh, J. (Josef), Vogelzangs, N. (Nicole), Karjalainen, J. (Juha), Willemsen, G.A.H.M. (Gonneke), Gharib, S.A. (Sina), Zgaga, L. (Lina), Mihailov, E. (Evelin), Stone, K.L. (Katie L), Campbell, H. (Harry), Brouwer, R.W.W. (Rutger), Demirkan, A. (Ayşe), Isaacs, A.J. (Aaron), Dogas, Z., Marciante, K. (Kristin), Campbell, S. (Susan), Borovecki, F. (Fran), Luik, A.I. (Annemarie), Li, M. (Man), Hottenga, J.J. (Jouke Jan), Huffman, J.E. (Jennifer), van den hout, M.C.G.N. (Mirjam), Cummings, S.R. (Steven R.), Aulchenko, Y.S. (Yurii), Gehrman, P.R. (Philip), Uitterlinden, A.G. (André), Wichmann, H.E. (Heinz Erich), Müller-Nurasyid, M. (Martina), Fehrmann, R.S.N. (Rudolf), Montgomery, G.W. (Grant), Hofman, A. (Albert), Kao, W.H.L. (Wen Hong Linda), Oostra, B.A. (Ben), Wright, A. (Alan), Vink, J.M. (Jacqueline), Wilson, J.F. (James F), Pramstaller, P.P. (Peter Paul), Hicks, A.A. (Andrew), Polasek, O. (Ozren), Punjabi, N.M. (Naresh), Redline, S. (Susan), Psaty, B.M. (Bruce), Heath, A.C. (Andrew C.), Merrow, M., Tranah, G.J. (Gregory), Gottlieb, D.J. (Daniel J), Boomsma, D.I. (Dorret), Martin, N.G. (Nicholas), Rudan, I. (Igor), Tiemeier, H.W. (Henning), IJcken, W.F.J. (Wilfred) van, Penninx, B.W.J.H., Metspalu, A. (Andres), Meitinger, T. (Thomas), Franke, L. (Lude), Roenneberg, T., Duijn, C.M. (Cornelia) van, Amin, N. (Najaf), Allebrandt, K.V., Spek, A. (Ashley) van der, Müller-Myhsok, B. (B.), Hek, K. (Karin), Teder-Laving, M. (Maris), Hayward, C. (Caroline), Esko, T. (Tõnu), Mill, J. van, Mbarek, H., Watson, N.F. (Nathaniel F), Melville, S.A. (Scott), Del Greco, F.M. (Fabiola), Byrne, E.M. (Enda), Oole, E. (Edwin), Kolcic, I. (Ivana), Chen, T.H., Evans, D.S. (Daniel), Coresh, J. (Josef), Vogelzangs, N. (Nicole), Karjalainen, J. (Juha), Willemsen, G.A.H.M. (Gonneke), Gharib, S.A. (Sina), Zgaga, L. (Lina), Mihailov, E. (Evelin), Stone, K.L. (Katie L), Campbell, H. (Harry), Brouwer, R.W.W. (Rutger), Demirkan, A. (Ayşe), Isaacs, A.J. (Aaron), Dogas, Z., Marciante, K. (Kristin), Campbell, S. (Susan), Borovecki, F. (Fran), Luik, A.I. (Annemarie), Li, M. (Man), Hottenga, J.J. (Jouke Jan), Huffman, J.E. (Jennifer), van den hout, M.C.G.N. (Mirjam), Cummings, S.R. (Steven R.), Aulchenko, Y.S. (Yurii), Gehrman, P.R. (Philip), Uitterlinden, A.G. (André), Wichmann, H.E. (Heinz Erich), Müller-Nurasyid, M. (Martina), Fehrmann, R.S.N. (Rudolf), Montgomery, G.W. (Grant), Hofman, A. (Albert), Kao, W.H.L. (Wen Hong Linda), Oostra, B.A. (Ben), Wright, A. (Alan), Vink, J.M. (Jacqueline), Wilson, J.F. (James F), Pramstaller, P.P. (Peter Paul), Hicks, A.A. (Andrew), Polasek, O. (Ozren), Punjabi, N.M. (Naresh), Redline, S. (Susan), Psaty, B.M. (Bruce), Heath, A.C. (Andrew C.), Merrow, M., Tranah, G.J. (Gregory), Gottlieb, D.J. (Daniel J), Boomsma, D.I. (Dorret), Martin, N.G. (Nicholas), Rudan, I. (Igor), Tiemeier, H.W. (Henning), IJcken, W.F.J. (Wilfred) van, Penninx, B.W.J.H., Metspalu, A. (Andres), Meitinger, T. (Thomas), Franke, L. (Lude), Roenneberg, T., and Duijn, C.M. (Cornelia) van

Abstract

Time to fall asleep (sleep latency) is a major determinant of sleep quality. Chronic, long sleep latency is a major characteristic of sleep-onset insomnia and/or delayed sleep phase syndrome. In this study we aimed to discover common polymorphisms that contribute to the genetics of sleep latency. We performed a meta-analysis of genome-wide association studies (GWAS) including 2 572 737 single nucleotide polymorphisms (SNPs) established in seven European cohorts including 4242 individuals. We found a cluster of three highly correlated variants (rs9900428, rs9907432 and rs7211029) in the RNA-binding protein fox-1 homolog 3 gene (RBFOX3) associated with sleep latency (P-values=5.77 × 10-08, 6.59 × 10- 08 and 9.17 × 10- 08). These SNPs were replicated in up to 12 independent populations including 30 377 individuals (P-values=1.5 × 10- 02, 7.0 × 10- 03 and 2.5 × 10- 03; combined meta-analysis P-values=5.5 × 10-07, 5.4 × 10-07 and 1.0 × 10-07). A functional prediction of RBFOX3 based

Published
2016
Full Text
View/download PDF

2. Novel loci associated with usual sleep duration: The CHARGE Consortium Genome-Wide Association Study

Author

Gottlieb, D.J. (Daniel J), Hek, K. (Karin), Chen, T.-H., Watson, N.F., Eiriksdottir, G. (Gudny), Byrne, E.M., Cornelis, M. (Marilyn), Warby, S.C., Bandinelli, S., Cherkas, L. (Lynn), Evans, D.S. (Daniel), Grabe, H.J. (Hans Jörgen), Lahti, J. (Jari), Li, M. (Man), Lehtimäki, T. (Terho), Lumley, T. (Thomas), Marciante, K. (Kristin), Perusse, L. (Louis), Psaty, B.M. (Bruce), Robbins, J., Tranah, G.J. (Gregory), Vink, J.M., Wilk, J.B., Stafford, J.M., Bellis, C. (Claire), Biffar, R., Bouchard, C. (Claude), Cade, B., Curhan, G.C. (Gary), Eriksson, J., Ewert, R., Ferrucci, L. (Luigi), Fülöp, T., Gehrman, P.R. (Philip), Goodloe, R. (Robert), Harris, T.B. (Tamara), Heath, A.C. (Andrew C.), Hernandez, D.G. (Dena), Hofman, A. (Albert), Hottenga, J.J. (Jouke Jan), Hunter, D. (David), Jensen, M.K. (Majken K.), Johnson, A.D. (Andrew), Kähönen, M. (Mika), Kao, W.H.L. (Wen), Kraft, P. (Peter), Larkin, E.K., Lauderdale, D.S., Luik, A.I. (Annemarie), Medici, M., Montgomery, G.W. (Grant W.), Palotie, A., Patel, S.R. (Sanjay), Pistis, G. (Giorgio), Porcu, E., Quaye, L. (Lydia), Raitakari, O. (Olli), Redline, S. (Susan), Rimm, E.B. (Eric B.), Rotter, J.I., Smith, A.V. (Albert), Spector, T.D. (Timothy), Teumer, A. (Alexander), Uitterlinden, A.G. (André), Vohl, M.-C. (Marie-Claude), Widen, E., Willemsen, G.A.H.M. (Gonneke), Young, T.L. (Terri L.), Zhang, X., Liu, Y., Blangero, J. (John), Boomsma, D.I. (Dorret), Gudnason, V. (Vilmundur), Hu, F., Mangino, M., Martin, N.G. (Nicholas), O'Connor, G.T. (George), Stone, K.L. (Katie L), Tanaka, T., Viikari, J. (Jorma), Gharib, S.A. (Sina), Punjabi, N.M. (Naresh), Räikkönen, K. (Katri), Völzke, H. (Henry), Mignot, E., Tiemeier, H.W. (Henning), Gottlieb, D.J. (Daniel J), Hek, K. (Karin), Chen, T.-H., Watson, N.F., Eiriksdottir, G. (Gudny), Byrne, E.M., Cornelis, M. (Marilyn), Warby, S.C., Bandinelli, S., Cherkas, L. (Lynn), Evans, D.S. (Daniel), Grabe, H.J. (Hans Jörgen), Lahti, J. (Jari), Li, M. (Man), Lehtimäki, T. (Terho), Lumley, T. (Thomas), Marciante, K. (Kristin), Perusse, L. (Louis), Psaty, B.M. (Bruce), Robbins, J., Tranah, G.J. (Gregory), Vink, J.M., Wilk, J.B., Stafford, J.M., Bellis, C. (Claire), Biffar, R., Bouchard, C. (Claude), Cade, B., Curhan, G.C. (Gary), Eriksson, J., Ewert, R., Ferrucci, L. (Luigi), Fülöp, T., Gehrman, P.R. (Philip), Goodloe, R. (Robert), Harris, T.B. (Tamara), Heath, A.C. (Andrew C.), Hernandez, D.G. (Dena), Hofman, A. (Albert), Hottenga, J.J. (Jouke Jan), Hunter, D. (David), Jensen, M.K. (Majken K.), Johnson, A.D. (Andrew), Kähönen, M. (Mika), Kao, W.H.L. (Wen), Kraft, P. (Peter), Larkin, E.K., Lauderdale, D.S., Luik, A.I. (Annemarie), Medici, M., Montgomery, G.W. (Grant W.), Palotie, A., Patel, S.R. (Sanjay), Pistis, G. (Giorgio), Porcu, E., Quaye, L. (Lydia), Raitakari, O. (Olli), Redline, S. (Susan), Rimm, E.B. (Eric B.), Rotter, J.I., Smith, A.V. (Albert), Spector, T.D. (Timothy), Teumer, A. (Alexander), Uitterlinden, A.G. (André), Vohl, M.-C. (Marie-Claude), Widen, E., Willemsen, G.A.H.M. (Gonneke), Young, T.L. (Terri L.), Zhang, X., Liu, Y., Blangero, J. (John), Boomsma, D.I. (Dorret), Gudnason, V. (Vilmundur), Hu, F., Mangino, M., Martin, N.G. (Nicholas), O'Connor, G.T. (George), Stone, K.L. (Katie L), Tanaka, T., Viikari, J. (Jorma), Gharib, S.A. (Sina), Punjabi, N.M. (Naresh), Räikkönen, K. (Katri), Völzke, H. (Henry), Mignot, E., and Tiemeier, H.W. (Henning)

Abstract

Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10 -9). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10 -4). The strongest combined association was at rs1823125 (P=1.5 × 10 -10, minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.

Published
2015
Full Text
View/download PDF

3. A genome-wide association study of depressive symptoms

Author

Hek, K. (Karin), Demirkan, A. (Ayşe), Lahti, J. (Jari), Terracciano, A., Teumer, A. (Alexander), Cornelis, M. (Marilyn), Amin, N. (Najaf), Bakshis, E. (Erin), Baumert, J. (Jens), Ding, J. (Jingzhong), Liu, Y. (YongMei), Marciante, K. (Kristin), Meirelles, O., Nalls, M.A. (Michael), Sun, Y.V. (Yan), Vogelzangs, N. (Nicole), Yu, L. (Lei), Bandinelli, S. (Stefania), Benjamin, E.J. (Emelia), Bennett, D.A. (David), Boomsma, D.I. (Dorret), Cannas, A., Coker, L.H. (Laura), Geus, E.J.C. (Eco) de, Jager, P.L. (Philip) de, Diez Roux, A.V. (Ana), Purcell, S. (Shaun), Hu, F.B. (Frank), Rimm, E., Hunter, D.J. (David), Jensen, M.K. (Majken), Curhan, G.C. (Gary), Rice, K.M. (Kenneth), Penman, A.D. (Alan), Rotter, J.I. (Jerome), Sotoodehnia, N. (Nona), Emeny, R. (Rebecca), Eriksson, J.G. (Johan), Evans, D.A. (Denis), Ferrucci, L. (Luigi), Fornage, M. (Myriam), Gudnason, V. (Vilmundur), Hofman, A. (Albert), Illig, T. (Thomas), Kardia, S.L.R. (Sharon), Kelly-Hayes, M. (Margaret), Koenen, M.E. (Marjorie), Kraft, P. (Peter), Kuningas, M. (Maris), Massaro, J. (Joseph), Melzer, D. (David), Mulas, A. (Antonella), Mulder, C.L. (Niels), Murray, A. (Anna), Oostra, B.A. (Ben), Palotie, A. (Aarno), Penninx, B.W.J.H. (Brenda), Petersmann, A. (Astrid), Pilling, L.C. (Luke), Psaty, B.M. (Bruce), Rawal, R. (Rajesh), Reiman, E.M. (Eric), Schulz, A. (Ansgar), Shulman, L. (Lee), Singleton, A.B. (Andrew), Smith, A.V. (Davey), Sutin, A.R., Uitterlinden, A.G. (André), Völzke, H. (Henry), Widen, E. (Elisabeth), Yaffe, K. (Kristine), Zonderman, A.B. (Alan), Cucca, F. (Francesco), Harris, T.B. (Tamara), Ladwig, K.-H. (Karl-Heinz), Llewellyn, D.J. (David), Räikkönen, K. (Katri), Tanaka, T. (Toshiko), Duijn, C.M. (Cornelia) van, Grabe, H.J. (Hans Jörgen), Launer, L.J. (Lenore), Lunetta, K.L. (Kathryn), Mosley, T.H. (Thomas), Newman, A.B. (Anne), Tiemeier, H.W. (Henning), Murabito, J. (Joanne), Hek, K. (Karin), Demirkan, A. (Ayşe), Lahti, J. (Jari), Terracciano, A., Teumer, A. (Alexander), Cornelis, M. (Marilyn), Amin, N. (Najaf), Bakshis, E. (Erin), Baumert, J. (Jens), Ding, J. (Jingzhong), Liu, Y. (YongMei), Marciante, K. (Kristin), Meirelles, O., Nalls, M.A. (Michael), Sun, Y.V. (Yan), Vogelzangs, N. (Nicole), Yu, L. (Lei), Bandinelli, S. (Stefania), Benjamin, E.J. (Emelia), Bennett, D.A. (David), Boomsma, D.I. (Dorret), Cannas, A., Coker, L.H. (Laura), Geus, E.J.C. (Eco) de, Jager, P.L. (Philip) de, Diez Roux, A.V. (Ana), Purcell, S. (Shaun), Hu, F.B. (Frank), Rimm, E., Hunter, D.J. (David), Jensen, M.K. (Majken), Curhan, G.C. (Gary), Rice, K.M. (Kenneth), Penman, A.D. (Alan), Rotter, J.I. (Jerome), Sotoodehnia, N. (Nona), Emeny, R. (Rebecca), Eriksson, J.G. (Johan), Evans, D.A. (Denis), Ferrucci, L. (Luigi), Fornage, M. (Myriam), Gudnason, V. (Vilmundur), Hofman, A. (Albert), Illig, T. (Thomas), Kardia, S.L.R. (Sharon), Kelly-Hayes, M. (Margaret), Koenen, M.E. (Marjorie), Kraft, P. (Peter), Kuningas, M. (Maris), Massaro, J. (Joseph), Melzer, D. (David), Mulas, A. (Antonella), Mulder, C.L. (Niels), Murray, A. (Anna), Oostra, B.A. (Ben), Palotie, A. (Aarno), Penninx, B.W.J.H. (Brenda), Petersmann, A. (Astrid), Pilling, L.C. (Luke), Psaty, B.M. (Bruce), Rawal, R. (Rajesh), Reiman, E.M. (Eric), Schulz, A. (Ansgar), Shulman, L. (Lee), Singleton, A.B. (Andrew), Smith, A.V. (Davey), Sutin, A.R., Uitterlinden, A.G. (André), Völzke, H. (Henry), Widen, E. (Elisabeth), Yaffe, K. (Kristine), Zonderman, A.B. (Alan), Cucca, F. (Francesco), Harris, T.B. (Tamara), Ladwig, K.-H. (Karl-Heinz), Llewellyn, D.J. (David), Räikkönen, K. (Katri), Tanaka, T. (Toshiko), Duijn, C.M. (Cornelia) van, Grabe, H.J. (Hans Jörgen), Launer, L.J. (Lenore), Lunetta, K.L. (Kathryn), Mosley, T.H. (Thomas), Newman, A.B. (Anne), Tiemeier, H.W. (Henning), and Murabito, J. (Joanne)

Abstract

Background: Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common variants for depressive symptoms. Methods: In this genome-wide association study, we combined the results of 17 population-based studies assessing depressive symptoms with the Center for Epidemiological Studies Depression Scale. Replication of the independent top hits (p<1×10-5) was performed in five studies assessing depressive symptoms with other instruments. In addition, we performed a combined meta-analysis of all 22 discovery and replication studies. Results: The discovery sample comprised 34,549 individuals (mean age of 66.5) and no loci reached genome-wide significance (lowest p = 1.05×10-7). Seven independent single nucleotide polymorphisms were considered for replication. In the replication set (n = 16,709), we found suggestive association of one single nucleotide polymorphism with depressive symptoms (rs161645, 5q21, p = 9.19×10-3). This 5q21 region reached genome-wide significance (p = 4.78×10-8) in the overall meta-analysis combining discovery and replication studies (n = 51,258). Conclusions: The results suggest that only a large sample comprising more than 50,000 subjects may be sufficiently powered to detect genes for depressive symptoms.

Published
2013
Full Text
View/download PDF

4. Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function

Author

Hancock, D.B. (Dana), Artigas, M.S., Gharib, S.A. (Sina), Henry, A. (Amanda), Manichaikul, A. (Ani), Ramasamy, A. (Adaikalavan), Loth, D.W. (Daan), Imboden, M. (Medea), Koch, B. (Beate), McArdle, W.L. (Wendy), Smith, A.V. (Davey), Smolonska, J. (Joanna), Sood, A. (Akshay), Tang, W. (Wenbo), Wilk, J.B. (Jemma), Zhai, G. (Guangju), Zhao, J.H. (Jing Hua), Aschard, H. (Hugues), Burkart, K.M. (Kristin), Curjuric, I. (Ivan), Eijgelsheim, M. (Mark), Elliott, P. (Paul), Gu, X. (Xiangjun), Harris, T.B. (Tamara), Janson, C. (Christer), Homuth, G. (Georg), Hysi, P.G. (Pirro), Liu, J. (Jason), Loehr, L.R. (Laura), Lohman, K. (Kurt), Loos, R.J.F. (Ruth), Manning, A.K. (Alisa), Marciante, K. (Kristin), Obeidat, M. (Ma'en), Postma, D.S. (Dirkje), Aldrich, M.C. (Melinda), Brusselle, G.G. (Guy), Chen, T.H., Eiriksdottir, G. (Gudny), Franceschini, N. (Nora), Heinrich, J. (Joachim), Rotter, J.I. (Jerome), Wijmenga, C. (Cisca), Williams, O.D. (Dale), Hofman, A. (Albert), Laurie, C.C. (Cathy), Lumley, T. (Thomas), Morrison, A.C. (Alanna), Joubert, B.R. (Bonnie), Rivadeneira Ramirez, F. (Fernando), Couper, D.J. (David), Kritchevsky, S.B. (Stephen), Liu, Y. (YongMei), Wjst, M. (Matthias), Wain, L.V. (Louise), Vonk, J.M. (Judith), Uitterlinden, A.G. (André), Rochat, T. (Thierry), Rich, S.S. (Stephen), Psaty, B.M. (Bruce), O'Connor, G.T. (George), North, K.E. (Kari), Mirel, D. (Daniel), Meibohm, B. (Bernd), Launer, L.J. (Lenore), Khaw, K-T. (Kay-Tee), Hartikainen, A.L., Hammond, C.J. (Christopher), Gläser, S. (Sven), Marchini, J. (Jonathan), Kraft, P. (Peter), Wareham, N.J. (Nick), Völzke, H. (Henry), Stricker, B.H.Ch. (Bruno), Spector, T.D. (Timothy), Probst-Hensch, N.M. (Nicole M.), Jarvis, D.L. (Deborah), Jarvelin, M.-R. (Marjo-Riitta), Heckbert, S.R. (Susan), Gudnason, V. (Vilmundur), Boezen, H.M. (Marike), Barr, R.G. (Graham), Cassano, P.A. (Patricia), Strachan, D.P. (David), Fornage, M. (Myriam), Hall, I.P. (Ian), Dupuis, J. (Josée), Tobin, M.D. (Martin), London, S.J. (Stephanie), Bentley, A.R. (Amy), Hancock, D.B. (Dana), Artigas, M.S., Gharib, S.A. (Sina), Henry, A. (Amanda), Manichaikul, A. (Ani), Ramasamy, A. (Adaikalavan), Loth, D.W. (Daan), Imboden, M. (Medea), Koch, B. (Beate), McArdle, W.L. (Wendy), Smith, A.V. (Davey), Smolonska, J. (Joanna), Sood, A. (Akshay), Tang, W. (Wenbo), Wilk, J.B. (Jemma), Zhai, G. (Guangju), Zhao, J.H. (Jing Hua), Aschard, H. (Hugues), Burkart, K.M. (Kristin), Curjuric, I. (Ivan), Eijgelsheim, M. (Mark), Elliott, P. (Paul), Gu, X. (Xiangjun), Harris, T.B. (Tamara), Janson, C. (Christer), Homuth, G. (Georg), Hysi, P.G. (Pirro), Liu, J. (Jason), Loehr, L.R. (Laura), Lohman, K. (Kurt), Loos, R.J.F. (Ruth), Manning, A.K. (Alisa), Marciante, K. (Kristin), Obeidat, M. (Ma'en), Postma, D.S. (Dirkje), Aldrich, M.C. (Melinda), Brusselle, G.G. (Guy), Chen, T.H., Eiriksdottir, G. (Gudny), Franceschini, N. (Nora), Heinrich, J. (Joachim), Rotter, J.I. (Jerome), Wijmenga, C. (Cisca), Williams, O.D. (Dale), Hofman, A. (Albert), Laurie, C.C. (Cathy), Lumley, T. (Thomas), Morrison, A.C. (Alanna), Joubert, B.R. (Bonnie), Rivadeneira Ramirez, F. (Fernando), Couper, D.J. (David), Kritchevsky, S.B. (Stephen), Liu, Y. (YongMei), Wjst, M. (Matthias), Wain, L.V. (Louise), Vonk, J.M. (Judith), Uitterlinden, A.G. (André), Rochat, T. (Thierry), Rich, S.S. (Stephen), Psaty, B.M. (Bruce), O'Connor, G.T. (George), North, K.E. (Kari), Mirel, D. (Daniel), Meibohm, B. (Bernd), Launer, L.J. (Lenore), Khaw, K-T. (Kay-Tee), Hartikainen, A.L., Hammond, C.J. (Christopher), Gläser, S. (Sven), Marchini, J. (Jonathan), Kraft, P. (Peter), Wareham, N.J. (Nick), Völzke, H. (Henry), Stricker, B.H.Ch. (Bruno), Spector, T.D. (Timothy), Probst-Hensch, N.M. (Nicole M.), Jarvis, D.L. (Deborah), Jarvelin, M.-R. (Marjo-Riitta), Heckbert, S.R. (Susan), Gudnason, V. (Vilmundur), Boezen, H.M. (Marike), Barr, R.G. (Graham), Cassano, P.A. (Patricia), Strachan, D.P. (David), Fornage, M. (Myriam), Hall, I.P. (Ian), Dupuis, J. (Josée), Tobin, M.D. (Martin), London, S.J. (Stephanie), and Bentley, A.R. (Amy)

Published
2012
Full Text
View/download PDF

5. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction

Author

Wilk, J.B. (Jemma), Shrine, N.R.G. (Nick), Loehr, L.R. (Laura), Zhao, J.H. (Jing Hua), Manichaikul, A. (Ani), Lopez, L.M. (Lorna), Smith, A.V. (Davey), Heckbert, S.R. (Susan), Smolonska, J. (Joanna), Tang, W. (Wenbo), Loth, D.W. (Daan), Curjuric, I. (Ivan), Hui, J. (Jennie), Cho, M.H. (Michael), Latourelle, J.C. (Jeanne), Henry, A. (Amanda), Aldrich, M.C. (Melinda), Bakke, A.B. (Arnold B.), Beaty, T.H. (Terri), Bentley, A.R. (Amy), Borecki, I.B. (Ingrid), Brusselle, G.G. (Guy), Burkart, K.M. (Kristin), Chen, T.H., Couper, D.J. (David), Crapo, R.O. (Robert), Davies, G. (Gail), Dupuis, J. (Josée), Franceschini, N. (Nora), Gulsvik, A. (Amund), Hancock, D.B. (Dana), Harris, T.B. (Tamara), Hofman, A. (Albert), Imboden, M. (Medea), James, A.L. (Alan), Khaw, K-T. (Kay-Tee), Lahousse, L. (Lies), Launer, L.J. (Lenore), Litonjua, A.A. (Augusto), Liu, Y. (YongMei), Lohman, K. (Kurt), Lomas, D.J. (David John), Lumley, T. (Thomas), Marciante, K. (Kristin), McArdle, W.L. (Wendy), Meibohm, B. (Bernd), Morrison, A.C. (Alanna), Musk, A.W. (Arthur), Myers, R.H. (Richard), North, K.E. (Kari), Postma, D.S. (Dirkje), Psaty, B.M. (Bruce), Rich, S.S. (Stephen), Rivadeneira Ramirez, F. (Fernando), Rochat, T. (Thierry), Rotter, J.I. (Jerome), Soler Artigas, M. (Maria), Starr, J.M. (John), Uitterlinden, A.G. (André), Wareham, N.J. (Nick), Wijmenga, C. (Cisca), Zanen, P. (Pieter), Province, M.A. (Mike), Silverman, E. (Edwin), Deary, I.J. (Ian), Palmer, C. (Cameron), Cassano, P.A. (Patricia), Gudnason, V. (Vilmundur), Barr, R.G. (Graham), Loos, R.J.F. (Ruth), Strachan, D.P. (David), London, S.J. (Stephanie), Boezen, H.M. (Marike), Probst-Hensch, N. (Nicole), Gharib, S.A. (Sina), Hall, I.P. (Ian), O'Connor, G.T. (George), Tobin, M.D. (Martin), Stricker, B.H.Ch. (Bruno), Wilk, J.B. (Jemma), Shrine, N.R.G. (Nick), Loehr, L.R. (Laura), Zhao, J.H. (Jing Hua), Manichaikul, A. (Ani), Lopez, L.M. (Lorna), Smith, A.V. (Davey), Heckbert, S.R. (Susan), Smolonska, J. (Joanna), Tang, W. (Wenbo), Loth, D.W. (Daan), Curjuric, I. (Ivan), Hui, J. (Jennie), Cho, M.H. (Michael), Latourelle, J.C. (Jeanne), Henry, A. (Amanda), Aldrich, M.C. (Melinda), Bakke, A.B. (Arnold B.), Beaty, T.H. (Terri), Bentley, A.R. (Amy), Borecki, I.B. (Ingrid), Brusselle, G.G. (Guy), Burkart, K.M. (Kristin), Chen, T.H., Couper, D.J. (David), Crapo, R.O. (Robert), Davies, G. (Gail), Dupuis, J. (Josée), Franceschini, N. (Nora), Gulsvik, A. (Amund), Hancock, D.B. (Dana), Harris, T.B. (Tamara), Hofman, A. (Albert), Imboden, M. (Medea), James, A.L. (Alan), Khaw, K-T. (Kay-Tee), Lahousse, L. (Lies), Launer, L.J. (Lenore), Litonjua, A.A. (Augusto), Liu, Y. (YongMei), Lohman, K. (Kurt), Lomas, D.J. (David John), Lumley, T. (Thomas), Marciante, K. (Kristin), McArdle, W.L. (Wendy), Meibohm, B. (Bernd), Morrison, A.C. (Alanna), Musk, A.W. (Arthur), Myers, R.H. (Richard), North, K.E. (Kari), Postma, D.S. (Dirkje), Psaty, B.M. (Bruce), Rich, S.S. (Stephen), Rivadeneira Ramirez, F. (Fernando), Rochat, T. (Thierry), Rotter, J.I. (Jerome), Soler Artigas, M. (Maria), Starr, J.M. (John), Uitterlinden, A.G. (André), Wareham, N.J. (Nick), Wijmenga, C. (Cisca), Zanen, P. (Pieter), Province, M.A. (Mike), Silverman, E. (Edwin), Deary, I.J. (Ian), Palmer, C. (Cameron), Cassano, P.A. (Patricia), Gudnason, V. (Vilmundur), Barr, R.G. (Graham), Loos, R.J.F. (Ruth), Strachan, D.P. (David), London, S.J. (Stephanie), Boezen, H.M. (Marike), Probst-Hensch, N. (Nicole), Gharib, S.A. (Sina), Hall, I.P. (Ian), O'Connor, G.T. (George), Tobin, M.D. (Martin), and Stricker, B.H.Ch. (Bruno)

Abstract

Rationale: Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known. Objectives: Perform meta-analyses of GWAS for airflow obstruction, a key pathophysiologic characteristic ofCOPD assessedby spirometry, in population-based cohorts examining all participants, ever smokers, never smokers, asthma-free participants, and more severe cases. Methods: Fif

Published
2012
Full Text
View/download PDF

6. A genome-wide association study of aging

Author

Walter, S. (Stefan), Atzmon, G. (Gil), Demerath, E.W. (Ellen), Garcia, M. (Melissa), Kaplan, R.C. (Robert), Kumari, M. (Meena), Lunetta, K.L. (Kathryn), Milaneschi, Y. (Yuri), Tanaka, T. (Toshiko), Tranah, G.J. (Gregory), Völker, U. (Uwe), Yu, L. (Lei), Arnold, A.M. (Alice), Benjamin, E.J. (Emelia), Biffar, R. (Reiner), Buchman, A.S. (Aron), Boerwinkle, E.A. (Eric), Couper, D. (David), Jager, P.L. (Philip) de, Evans, D.A. (Denis), Harris, T.B. (Tamara), Hoffmann, W. (Wolfgang), Hofman, A. (Albert), Karasik, D. (David), Kiel, D.P. (Douglas), Kocher, T. (Thomas), Kuningas, M. (Maris), Launer, L.J. (Lenore), Lohman, K. (Kurt), Lutsey, P.L. (Pamela), Mackenbach, J.P. (Johan), Marciante, K. (Kristin), Psaty, B.M. (Bruce), Reiman, E.M. (Eric), Rotter, J.I. (Jerome), Seshadri, S. (Sudha), Shardell, M.D. (Michelle), Smith, A.V. (Albert Vernon), Tikka-Kleemola, P. (Päivi), Walston, J. (Jeremy), Zillikens, M.C. (Carola), Bandinelli, S. (Stefania), Baumeister, S.E. (Sebastian), Bennett, D.A. (David), Ferrucci, L. (Luigi), Gudnason, V. (Vilmundur), Kivimaki, M. (Mika), Liu, Y. (YongMei), Murabito, J. (Joanne), Newman, A.B. (Anne), Tiemeier, H.W. (Henning), Franceschini, N. (Nora), Walter, S. (Stefan), Atzmon, G. (Gil), Demerath, E.W. (Ellen), Garcia, M. (Melissa), Kaplan, R.C. (Robert), Kumari, M. (Meena), Lunetta, K.L. (Kathryn), Milaneschi, Y. (Yuri), Tanaka, T. (Toshiko), Tranah, G.J. (Gregory), Völker, U. (Uwe), Yu, L. (Lei), Arnold, A.M. (Alice), Benjamin, E.J. (Emelia), Biffar, R. (Reiner), Buchman, A.S. (Aron), Boerwinkle, E.A. (Eric), Couper, D. (David), Jager, P.L. (Philip) de, Evans, D.A. (Denis), Harris, T.B. (Tamara), Hoffmann, W. (Wolfgang), Hofman, A. (Albert), Karasik, D. (David), Kiel, D.P. (Douglas), Kocher, T. (Thomas), Kuningas, M. (Maris), Launer, L.J. (Lenore), Lohman, K. (Kurt), Lutsey, P.L. (Pamela), Mackenbach, J.P. (Johan), Marciante, K. (Kristin), Psaty, B.M. (Bruce), Reiman, E.M. (Eric), Rotter, J.I. (Jerome), Seshadri, S. (Sudha), Shardell, M.D. (Michelle), Smith, A.V. (Albert Vernon), Tikka-Kleemola, P. (Päivi), Walston, J. (Jeremy), Zillikens, M.C. (Carola), Bandinelli, S. (Stefania), Baumeister, S.E. (Sebastian), Bennett, D.A. (David), Ferrucci, L. (Luigi), Gudnason, V. (Vilmundur), Kivimaki, M. (Mika), Liu, Y. (YongMei), Murabito, J. (Joanne), Newman, A.B. (Anne), Tiemeier, H.W. (Henning), and Franceschini, N. (Nora)

Abstract

Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for 2 outcomes: (1) all-cause mortality, and (2) survival free of major disease or death. No single nucleotide polymorphism (SNP) was a genome-wide significant predictor of either outcome (p < 5 × 10-8). We found 14 independent SNPs that predicted risk of death, and 8 SNPs that predicted event-free survival (p < 10-5). These SNPs are in or near genes that are highly expressed in the brain (HECW2, HIP1, BIN2, GRIA1), genes involved in neural development and function (KCNQ4, LMO4, GRIA1, NETO1) and autophagy (ATG4C), and genes that are associated with risk of various diseases including cancer and Alzheimer's disease. In addition to considerable overlap between the traits, pathway and network analysis corroborated these findings. These findings indicate that variation in genes involved in neurological processes may be an important factor in regulating aging free of major disease and achieving longevity.

Published
2011
Full Text
View/download PDF

7. RANTES/CCL5 and risk for coronary events: Results from the MONICA/KORA Augsburg case-cohort, Athero-express and CARDIoGRAM studies

Author

Kathiresan, S. (Sekar), Reilly, M.P. (Muredach), Samani, N.J. (Nilesh), Schunkert, H. (Heribert), Erdmann, J. (Jeanette), Moll, F.L. (Frans), Boerwinkle, E.A. (Eric), Hall, A. (Anne), Hengstenberg, C. (Christian), König, I.R. (Inke), Laaksonen, R. (Reijo), McPherson, R. (Ruth), Thompson, J.R. (John), Thorsteinsdottir, U. (Unnur), Ziegler, A. (Andreas), Koenig, W. (Wolfgang), Chen, L. (Li), Cupples, L.A. (Adrienne), Halperin, E. (Eran), Musunuru, K. (Kiran), Preuss, M. (Michael), Schillert, A. (Arne), Thorleifsson, G. (Gudmar), Voight, B.F. (Benjamin), Wells, G.A. (George), Deloukas, P. (Panagiotis), Holm, H. (Hilma), Roberts, R. (Robert), Stewart, A.F.R. (Alexandre), Fortmann, S.P. (Stephen), Go, A.T.J.I. (Attie), Hlatky, M.A. (Mark), Iribarren, C. (Carlos), Knowles, J.W. (Joshua), Myers, R.H. (Richard), Quertermous, T. (Thomas), Sidney, S. (Steven), Risch, N., Tang, H. (Hui), Blankenberg, S. (Stefan), Zeller, T. (Tanja), Wild, P.S. (Philipp), Schnabel, R.B. (Renate), Sinning, C. (Christoph), Lackner, K.J. (Karl), Tiret, L. (Laurence), Nicaud, V., Cambien, F. (François), Bickel, H. (Horst), Rupprecht, H.J., Perret, C. (Claire), Proust, C. (Carole), Munzel, T. (Thomas), Barbalic, M. (maja), Bis, J.C. (Joshua), Chen, I.Y.-D. (Ida Yii-Der), Dehghan, A. (Abbas), Demissie-Banjaw, S. (Serkalem), Folsom, A.R. (Aaron), Glazer, N.L. (Nicole), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Heckbert, S.R. (Susan), Levy, D. (Daniel), Lumley, T. (Thomas), Marciante, K. (Kristin), Morrison, A.C. (Alanna), O'Donnell, C.J. (Christopher), Psaty, B.M. (Bruce), Rice, K. (Kenneth), Rotter, J.I. (Jerome), Siscovick, D.S. (David), Smith, N.L. (Nicholas), Smith, A.V. (Davey), Taylor, K.D. (Kent), Duijn, C.M. (Cornelia) van, Volcik, K.A. (Kelly), Whitteman, J. (Jaqueline), Ramachandran, V.S. (Vasan), Hofman, A. (Albert), Uitterlinden, A.G. (André), Gretarsdottir, S. (Solveig), Gulcher, J.R. (Jeffrey), Kong, A. (Augustine), Zwart, J-A. (John-Anker), Thorgeirsson, G. (Gudmundur), Andersen, K.K. (Karl), Fischer, M. (Marcus), Großhennig, A. (Anika), Lieb, W. (Wolfgang), Linsel-Nitschke, P. (Patrick), Stark, K. (Klaus), Schreiber, S. (Stefan), Wichmann, H.E. (Heinz Erich), Aherrahrou, Z. (Zouhair), Bruse, P. (Petra), Doering, A. (Angela), Illig, T. (Thomas), Klopp, N. (Norman), Loley, C. (Christina), Medack, A. (Anja), Meisinger, C. (Christa), Meitinger, T. (Thomas), Nahrstedt, J. (Janja), Peters, A. (Annette), Wagner, A.K. (Arnika), Willenborg, C. (Christina), Böhm, B., Dobnig, H. (Harald), Grammer, T.B. (Tanja), Hoffmann, M.M. (Michael), Kleber, M. (Martina), März, W. (Winfried), Meinitzer, A. (Andreas), Winkelmann, B., Pilz, D.T. (Daniela), Renner, W. (Wilfried), Scharnagl, H. (Hubert), Stojakovic, T. (Tatjana), Tomaschitz, A. (Andreas), Winkler, K. (Karl), Guiducci, C. (Candace), Burtt, N.P. (Noël), Gabriel, S.B. (Stacey), Elosua, R. (Roberto), Peltonen, L. (Leena Johanna), Salomaa, V. (Veikko), Schwartz, S.M. (Stephen), Melander, O. (Olle), Altshuler, D. (David), Dandona, S. (Sonny), Jarinova, O. (Olga), Qu, L. (Liming), Wilensky, A. (Asaf), Matthai, W. (William), Hakonarson, H. (Hakon), Devaney, J. (Joseph), Burnett, M.S., Pichard, A.D., Kent, K.M. (Kenneth), Satler, L.F., Lindsay, J.M. (Joseph), Waksman, R. (Ron), Knouff, C.W. (Christopher), Waterworth, D. (Dawn), Walker, M.C. (Max), Mooser, V. (Vincent), Epstein, S.E. (Stephen), Rader, D.J. (Daniel), Braund, P.S. (Peter), Nelson, C.P. (Christopher P.), Li, M. (Mingyao), Wright, B.J. (Benjamin), Balmforth, A.J. (Anthony), Ball, S.G. (Stephen), Kathiresan, S. (Sekar), Reilly, M.P. (Muredach), Samani, N.J. (Nilesh), Schunkert, H. (Heribert), Erdmann, J. (Jeanette), Moll, F.L. (Frans), Boerwinkle, E.A. (Eric), Hall, A. (Anne), Hengstenberg, C. (Christian), König, I.R. (Inke), Laaksonen, R. (Reijo), McPherson, R. (Ruth), Thompson, J.R. (John), Thorsteinsdottir, U. (Unnur), Ziegler, A. (Andreas), Koenig, W. (Wolfgang), Chen, L. (Li), Cupples, L.A. (Adrienne), Halperin, E. (Eran), Musunuru, K. (Kiran), Preuss, M. (Michael), Schillert, A. (Arne), Thorleifsson, G. (Gudmar), Voight, B.F. (Benjamin), Wells, G.A. (George), Deloukas, P. (Panagiotis), Holm, H. (Hilma), Roberts, R. (Robert), Stewart, A.F.R. (Alexandre), Fortmann, S.P. (Stephen), Go, A.T.J.I. (Attie), Hlatky, M.A. (Mark), Iribarren, C. (Carlos), Knowles, J.W. (Joshua), Myers, R.H. (Richard), Quertermous, T. (Thomas), Sidney, S. (Steven), Risch, N., Tang, H. (Hui), Blankenberg, S. (Stefan), Zeller, T. (Tanja), Wild, P.S. (Philipp), Schnabel, R.B. (Renate), Sinning, C. (Christoph), Lackner, K.J. (Karl), Tiret, L. (Laurence), Nicaud, V., Cambien, F. (François), Bickel, H. (Horst), Rupprecht, H.J., Perret, C. (Claire), Proust, C. (Carole), Munzel, T. (Thomas), Barbalic, M. (maja), Bis, J.C. (Joshua), Chen, I.Y.-D. (Ida Yii-Der), Dehghan, A. (Abbas), Demissie-Banjaw, S. (Serkalem), Folsom, A.R. (Aaron), Glazer, N.L. (Nicole), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Heckbert, S.R. (Susan), Levy, D. (Daniel), Lumley, T. (Thomas), Marciante, K. (Kristin), Morrison, A.C. (Alanna), O'Donnell, C.J. (Christopher), Psaty, B.M. (Bruce), Rice, K. (Kenneth), Rotter, J.I. (Jerome), Siscovick, D.S. (David), Smith, N.L. (Nicholas), Smith, A.V. (Davey), Taylor, K.D. (Kent), Duijn, C.M. (Cornelia) van, Volcik, K.A. (Kelly), Whitteman, J. (Jaqueline), Ramachandran, V.S. (Vasan), Hofman, A. (Albert), Uitterlinden, A.G. (André), Gretarsdottir, S. (Solveig), Gulcher, J.R. (Jeffrey), Kong, A. (Augustine), Zwart, J-A. (John-Anker), Thorgeirsson, G. (Gudmundur), Andersen, K.K. (Karl), Fischer, M. (Marcus), Großhennig, A. (Anika), Lieb, W. (Wolfgang), Linsel-Nitschke, P. (Patrick), Stark, K. (Klaus), Schreiber, S. (Stefan), Wichmann, H.E. (Heinz Erich), Aherrahrou, Z. (Zouhair), Bruse, P. (Petra), Doering, A. (Angela), Illig, T. (Thomas), Klopp, N. (Norman), Loley, C. (Christina), Medack, A. (Anja), Meisinger, C. (Christa), Meitinger, T. (Thomas), Nahrstedt, J. (Janja), Peters, A. (Annette), Wagner, A.K. (Arnika), Willenborg, C. (Christina), Böhm, B., Dobnig, H. (Harald), Grammer, T.B. (Tanja), Hoffmann, M.M. (Michael), Kleber, M. (Martina), März, W. (Winfried), Meinitzer, A. (Andreas), Winkelmann, B., Pilz, D.T. (Daniela), Renner, W. (Wilfried), Scharnagl, H. (Hubert), Stojakovic, T. (Tatjana), Tomaschitz, A. (Andreas), Winkler, K. (Karl), Guiducci, C. (Candace), Burtt, N.P. (Noël), Gabriel, S.B. (Stacey), Elosua, R. (Roberto), Peltonen, L. (Leena Johanna), Salomaa, V. (Veikko), Schwartz, S.M. (Stephen), Melander, O. (Olle), Altshuler, D. (David), Dandona, S. (Sonny), Jarinova, O. (Olga), Qu, L. (Liming), Wilensky, A. (Asaf), Matthai, W. (William), Hakonarson, H. (Hakon), Devaney, J. (Joseph), Burnett, M.S., Pichard, A.D., Kent, K.M. (Kenneth), Satler, L.F., Lindsay, J.M. (Joseph), Waksman, R. (Ron), Knouff, C.W. (Christopher), Waterworth, D. (Dawn), Walker, M.C. (Max), Mooser, V. (Vincent), Epstein, S.E. (Stephen), Rader, D.J. (Daniel), Braund, P.S. (Peter), Nelson, C.P. (Christopher P.), Li, M. (Mingyao), Wright, B.J. (Benjamin), Balmforth, A.J. (Anthony), and Ball, S.G. (Stephen)

Abstract

Background: The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be reflected by associations between CCL5 gene variants, RANTES serum concentrations and protein levels in atherosclerotic plaques and risk for coronary events. Methods and Findings: We conducted a case-cohort study within the population-based MONICA/KORA Augsburg studies. Baseline RANTES serum levels were measured in 363 individuals with incident coronary events and 1,908 non-cases (mean follow-up: 10.2±4

Published
2011
Full Text
View/download PDF

8. Genome-wide association study of PR interval

Author

Pfeufer, A. (Arne), Noord, C. (Charlotte) van, Marciante, K. (Kristin), Arking, D.E. (Dan), Larson, M.G. (Martin), Smith, A.V. (Albert Vernon), Tarasov, K.V. (Kirill), Müller, M. (Martina), Sotoodehnia, N. (Nona), Sinner, M.F. (Moritz), Verwoert, G.C. (Germaine), Li, M. (Man), Kao, W.H.L. (Wen), Köttgen, A. (Anna), Coresh, J. (Josef), Bis, J.C. (Joshua), Psaty, B.M. (Bruce), Rice, K. (Kenneth), Rotter, J.I. (Jerome), Rivadeneira Ramirez, F. (Fernando), Hofman, A. (Albert), Kors, J.A. (Jan), Stricker, B.H.Ch. (Bruno), Uitterlinden, A.G. (André), Tikka-Kleemola, P. (Päivi), Beckmann, B.M. (Britt), Sauter, W. (Wiebke), Gieger, C. (Christian), Lubitz, S.A. (Steven), Newton-Cheh, C. (Christopher), Wang, T.J. (Thomas), Magnani, J.W. (Jared), Schnabel, R. (Renate), Chung, M.K. (Mina), Barnard, J. (John), Wagoner, D.R. (David) van, Vasan, R.S. (Ramachandran Srini), Aspelund, T. (Thor), Eiriksdottir, G. (Gudny), Harris, T.B. (Tamara), Launer, L.J. (Lenore), Najjar, S.S. (Samer), Lakatta, E. (Edward), Schlessinger, D. (David), Uda, M. (Manuela), Abecasis, G.R. (Gonçalo), Artto, V. (Ville), Ehret, G.B. (Georg), Boerwinkle, E.A. (Eric), Chakravarti, A. (Aravinda), Soliman, E.Z. (Elsayed), Lunetta, K.L. (Kathryn), Perz, S. (Siegfried), Wichmann, H.E. (Erich), Meitinger, T. (Thomas), Levy, D. (Daniel), Gudnason, V. (Vilmundur), Ellinor, P.T. (Patrick), Sanna, S. (Serena), Kääb, S. (Stefan), Witteman, J.C.M. (Jacqueline), Alonso, A. (Alvaro), Benjamin, E.J. (Emelia), Heckbert, S.R. (Susan), Pfeufer, A. (Arne), Noord, C. (Charlotte) van, Marciante, K. (Kristin), Arking, D.E. (Dan), Larson, M.G. (Martin), Smith, A.V. (Albert Vernon), Tarasov, K.V. (Kirill), Müller, M. (Martina), Sotoodehnia, N. (Nona), Sinner, M.F. (Moritz), Verwoert, G.C. (Germaine), Li, M. (Man), Kao, W.H.L. (Wen), Köttgen, A. (Anna), Coresh, J. (Josef), Bis, J.C. (Joshua), Psaty, B.M. (Bruce), Rice, K. (Kenneth), Rotter, J.I. (Jerome), Rivadeneira Ramirez, F. (Fernando), Hofman, A. (Albert), Kors, J.A. (Jan), Stricker, B.H.Ch. (Bruno), Uitterlinden, A.G. (André), Tikka-Kleemola, P. (Päivi), Beckmann, B.M. (Britt), Sauter, W. (Wiebke), Gieger, C. (Christian), Lubitz, S.A. (Steven), Newton-Cheh, C. (Christopher), Wang, T.J. (Thomas), Magnani, J.W. (Jared), Schnabel, R. (Renate), Chung, M.K. (Mina), Barnard, J. (John), Wagoner, D.R. (David) van, Vasan, R.S. (Ramachandran Srini), Aspelund, T. (Thor), Eiriksdottir, G. (Gudny), Harris, T.B. (Tamara), Launer, L.J. (Lenore), Najjar, S.S. (Samer), Lakatta, E. (Edward), Schlessinger, D. (David), Uda, M. (Manuela), Abecasis, G.R. (Gonçalo), Artto, V. (Ville), Ehret, G.B. (Georg), Boerwinkle, E.A. (Eric), Chakravarti, A. (Aravinda), Soliman, E.Z. (Elsayed), Lunetta, K.L. (Kathryn), Perz, S. (Siegfried), Wichmann, H.E. (Erich), Meitinger, T. (Thomas), Levy, D. (Daniel), Gudnason, V. (Vilmundur), Ellinor, P.T. (Patrick), Sanna, S. (Serena), Kääb, S. (Stefan), Witteman, J.C.M. (Jacqueline), Alonso, A. (Alvaro), Benjamin, E.J. (Emelia), and Heckbert, S.R. (Susan)

Abstract

The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N = 28,517). We identified nine loci associated with PR interval at P 5 × 10 8. At the 3p22.2 locus, we observed two independent associations in voltage-gated sodium channel genes, SCN10A and SCN5A. Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes. Five of the loci, SCN5A, SCN10A, NKX2-5, CAV1-CAV2, and SOX5, were also associated with atrial fibrillation (N = 5,741 cases, P 0.0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation.

Published
2010
Full Text
View/download PDF

9. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

Author

Hancock, D.B. (Dana), Eijgelsheim, M. (Mark), Wilk, J.B. (Jemma), Gharib, S.A. (Sina), Loehr, L.R. (Laura), Marciante, K. (Kristin), Franceschini, N. (Nora), Durme, Y.M.T.A. van, Chen, T.H., Barr, R.G. (Graham), Schabath, M.B. (Matthew), Couper, D.J. (David), Brusselle, G.G. (Guy), Psaty, B.M. (Bruce), Tikka-Kleemola, P. (Päivi), Rotter, J.I. (Jerome), Uitterlinden, A.G. (André), Hofman, A. (Albert), Punjabi, N.M. (Naresh), Rivadeneira Ramirez, F. (Fernando), Morrison, A.C. (Alanna), Enright, P.L. (Paul), North, K.E. (Kari), Heckbert, S.R. (Susan), Lumley, T. (Thomas), Stricker, B.H.Ch. (Bruno), O'Connor, G.T. (George), London, S.J. (Stephanie), Hancock, D.B. (Dana), Eijgelsheim, M. (Mark), Wilk, J.B. (Jemma), Gharib, S.A. (Sina), Loehr, L.R. (Laura), Marciante, K. (Kristin), Franceschini, N. (Nora), Durme, Y.M.T.A. van, Chen, T.H., Barr, R.G. (Graham), Schabath, M.B. (Matthew), Couper, D.J. (David), Brusselle, G.G. (Guy), Psaty, B.M. (Bruce), Tikka-Kleemola, P. (Päivi), Rotter, J.I. (Jerome), Uitterlinden, A.G. (André), Hofman, A. (Albert), Punjabi, N.M. (Naresh), Rivadeneira Ramirez, F. (Fernando), Morrison, A.C. (Alanna), Enright, P.L. (Paul), North, K.E. (Kari), Heckbert, S.R. (Susan), Lumley, T. (Thomas), Stricker, B.H.Ch. (Bruno), O'Connor, G.T. (George), and London, S.J. (Stephanie)

Abstract

Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV1) and its ratio to forced vital capacity (FEV1/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV 1 /FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV1(INTS12-GSTCD-NPNT) at or near genome-wide significance (P 5 × 10-8) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results