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1. Measuring the CMB spectral distortions with COSMO: the multi-mode antenna system

Author

Manzan, E., Albano, L., Franceschet, C., Battistelli, E. S., de Bernardis, P., Bersanelli, M., Cacciotti, F., Capponi, A., Columbro, F., Conenna, G., Coppi, G., Coppolecchia, A., D'Alessandro, G., De Gasperis, G., De Petris, M., Gervasi, M., Isopi, G., Lamagna, L., Limonta, A., Marchitelli, E., Masi, S., Mennella, A., Montonati, F., Nati, F., Occhiuzzi, A., Paiella, A., Pettinari, G., Piacentini, F., Piccirillo, L., Pisano, G., Tucker, C., and Zannoni, M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

In this work, we present the design and manufacturing of the two multi-mode antenna arrays of the COSMO experiment and the preliminary beam pattern measurements of their fundamental mode compared with simulations. COSMO is a cryogenic Martin-Puplett Fourier Transform Spectrometer that aims at measuring the isotropic y-type spectral distortion of the Cosmic Microwave Background from Antarctica, by performing differential measurements between the sky and an internal, cryogenic reference blackbody. To reduce the atmospheric contribution, a spinning wedge mirror performs fast sky-dips at varying elevations while fast, low-noise Kinetic Inductance detectors scan the interferogram. Two arrays of antennas couple the radiation to the detectors. Each array consists of nine smooth-walled multi-mode feed-horns, operating in the $120-180$ GHz and $210-300$ GHz range, respectively. The multi-mode propagation helps increase the instrumental sensitivity without employing large focal planes with hundreds of detectors. The two arrays have a step-linear and a linear profile, respectively, and are obtained by superimposing aluminum plates made with CNC milling. The simulated multi-mode beam pattern has a $\sim 20^{\circ} - 26^{\circ}$ FWHM for the low-frequency array and $\sim 16^{\circ}$ FWHM for the high-frequency one. The side lobes are below $-15$ dB. To characterize the antenna response, we measured the beam pattern of the fundamental mode using a Vector Network Analyzer, in far-field conditions inside an anechoic chamber at room temperature. We completed the measurements of the low-frequency array and found a good agreement with the simulations. We also identified a few non-idealities that we attribute to the measuring setup and will further investigate. A comprehensive multi-mode measurement will be feasible at cryogenic temperature once the full receiver is integrated., Comment: To appear in Proceedings of the SPIE Astronomical Telescopes + Instrumentation, 2024

Published
2024

2. The LiteBIRD mission to explore cosmic inflation

Author

Ghigna, T., Adler, A., Aizawa, K., Akamatsu, H., Akizawa, R., Allys, E., Anand, A., Aumont, J., Austermann, J., Azzoni, S., Baccigalupi, C., Ballardini, M., Banday, A. J., Barreiro, R. B., Bartolo, N., Basak, S., Basyrov, A., Beckman, S., Bersanelli, M., Bortolami, M., Bouchet, F., Brinckmann, T., Campeti, P., Carinos, E., Carones, A., Casas, F. J., Cheung, K., Chinone, Y., Clermont, L., Columbro, F., Coppolecchia, A., Curtis, D., de Bernardis, P., de Haan, T., de la Hoz, E., De Petris, M., Della Torre, S., Monache, G. Delle, Di Giorgi, E., Dickinson, C., Diego-Palazuelos, P., García, J. J. Díaz, Dobbs, M., Dotani, T., D'Alessandro, G., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Farias, N., Ferreira, E., Franceschet, C., Fuskeland, U., Galloni, G., Galloway, M., Ganga, K., Gerbino, M., Gervasi, M., Génova-Santos, R. T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., González, R. González, Grandsire, L., Gruppuso, A., Halverson, N. W., Hargrave, P., Harper, S. E., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Herranz, D., Hivon, E., Hlozek, R. A., Hoang, T. D., Hubmayr, J., Ichiki, K., Ikuma, K., Ishino, H., Jaehnig, G., Jost, B., Kohri, K., Konishi, K., Lamagna, L., Lattanzi, M., Leloup, C., Levrier, F., Lonappan, A. I., Luzzi, G., Macias-Perez, J., Maffei, B., Marchitelli, E., Martínez-González, E., Masi, S., Matarrese, S., Matsumura, T., Micheli, S., Migliaccio, M., Monelli, M., Montier, L., Morgante, G., Mousset, L., Nagano, Y., Nagata, R., Natoli, P., Novelli, A., Noviello, F., Obata, I., Occhiuzzi, A., Odagiri, K., Omae, R., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Patanchon, G., Pavlidou, V., Piacentini, F., Piat, M., Piccirilli, G., Pinchera, M., Pisano, G., Porcelli, L., Raffuzzi, N., Raum, C., Remazeilles, M., Ritacco, A., Rubino-Martin, J., Ruiz-Granda, M., Sakurai, Y., Savini, G., Scott, D., Sekimoto, Y., Shiraishi, M., Signorelli, G., Stever, S. L., Sullivan, R. M., Suzuki, A., Takaku, R., Takakura, H., Takakura, S., Tartari, Y. Takase. A., Tassis, K., Thompson, K. L., Tomasi, M., Tristram, M., Tucker, C., Vacher, L., van Tent, B., Vielva, P., Watanuki, K., Wehus, I. K., Westbrook, B., Weymann-Despres, G., Winter, B., Wollack, E. J., Zacchei, A., Zannoni, M., Zhou, Y., and Collaboration, the LiteBIRD

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, Physics - Instrumentation and Detectors
Abstract

LiteBIRD, the next-generation cosmic microwave background (CMB) experiment, aims for a launch in Japan's fiscal year 2032, marking a major advancement in the exploration of primordial cosmology and fundamental physics. Orbiting the Sun-Earth Lagrangian point L2, this JAXA-led strategic L-class mission will conduct a comprehensive mapping of the CMB polarization across the entire sky. During its 3-year mission, LiteBIRD will employ three telescopes within 15 unique frequency bands (ranging from 34 through 448 GHz), targeting a sensitivity of 2.2\,$\mu$K-arcmin and a resolution of 0.5$^\circ$ at 100\,GHz. Its primary goal is to measure the tensor-to-scalar ratio $r$ with an uncertainty $\delta r = 0.001$, including systematic errors and margin. If $r \geq 0.01$, LiteBIRD expects to achieve a $>5\sigma$ detection in the $\ell=$2-10 and $\ell=$11-200 ranges separately, providing crucial insight into the early Universe. We describe LiteBIRD's scientific objectives, the application of systems engineering to mission requirements, the anticipated scientific impact, and the operations and scanning strategies vital to minimizing systematic effects. We will also highlight LiteBIRD's synergies with concurrent CMB projects., Comment: 23 pages, 9 figures, 1 table, SPIE Astronomical Telescopes + Instrumentation 2024

Published
2024

4. Measuring the CMB primordial B-modes with Bolometric Interferometry

Author

Mennella, A., Ade, P., Almela, A., Amico, G., Arnaldi, L. H., Aumont, J., Banfi, S., Battistelli, E. S., Bélier, B., Bergé, L., Bernard, J. -Ph., de Bernardis, P., Bersanelli, M., Bonaparte, J., Bonilla, J. D., Bunn, E., Buzi, D., Cacciotti, F., Camilieri, D., Cavaliere, F., Chanial, P., Chapron, C., Colombo, L., Columbro, F., Coppolecchia, A., Costanza, M. B., D'Alessandro, G., De Gasperis, G., De Leo, M., De Petris, M., Del Castillo, N., Dheilly, S., Etchegoyen, A., Ferazzoli, S., Ferreyro, L. P., Franceschet, C., Lerena, M. M. Gamboa, Ganga, K., García, B., Redondo, M. E. García, Gayer, D., Geria, J. M., Gervasi, M., Giard, M., Gilles, V., Berisso, M. Gómez, Gonzalez, M., Gradziel, M., Grandsire, L., Hamilton, J. -Ch., Hampel, M. R., Isopi, G., Kaplan, J., Lamagna, L., Lazarte, F., Loucatos, S., Maffei, B., Mancilla, A., Mandelli, S., Manzan, E., Marchitelli, E., Marnieros, S., Marty, W., Masi, S., May, A., Maya, J., McCulloch, M., Mele, L., Melo, D., Mirón-Granese, N., Montier, L., Mousset, L., Müller, N., Nati, F., O'Sullivan, C., Paiella, A., Pajot, F., Paradiso, S., Pascale, E., Passerini, A., Pelosi, A., Perciballi, M., Pezzotta, F., Piacentini, F., Piat, M., Piccirillo, L., Pisano, G., Platino, M., Polenta, G., Prêle, D., Rambaud, D., Ramos, G., Rasztocky, E., Régnier, M., Reyes, C., Rodríguez, F., Rodríguez, C. A., Romero, G. E., Salum, J. M., Schillaci, A., Scóccola, C., Stankowiak, G., Tartari, A., Thermeau, J. -P., Timbie, P., Tomasi, M., Torchinsky, S., Tucker, G., Tucker, C., Vacher, L., Voisin, F., Wright, M., Zannoni, M., and Zullo, A.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Q&U Bolometric Interferometer for Cosmology (QUBIC) is the first bolometric interferometer designed to measure the primordial B-mode polarization of the Cosmic Microwave Background (CMB). Bolometric interferometry is a novel technique that combines the sensitivity of bolometric detectors with the control of systematic effects that is typical of interferometry, both key features in the quest for the faint signal of the primordial B-modes. A unique feature is the so-called "spectral imaging", i.e., the ability to recover the sky signal in several sub-bands within the physical band during data analysis. This feature provides an in-band spectral resolution of \Delta{\nu}/{\nu} \sim 0.04 that is unattainable by a traditional imager. This is a key tool for controlling the Galactic foregrounds contamination. In this paper, we describe the principles of bolometric interferometry, the current status of the QUBIC experiment and future prospects., Comment: To appear in Proc. of the mm Universe 2023 conference, Grenoble (France), June 2023, published by F. Mayet et al. (Eds), EPJ Web of conferences, EDP Sciences

Published
2023

5. The COSmic Monopole Observer (COSMO)

Author

Masi, S., Battistelli, E., de Bernardis, P., Coppolecchia, A., Columbro, F., D'Alessandro, G., De Petris, M., Lamagna, L., Marchitelli, E., Mele, L., Paiella, A., Piacentini, F., Pisano, G., Bersanelli, M., Franceschet, C., Manzan, E., Mennella, D., Realini, S., Cibella, S., Martini, F., Pettinari, G., Coppi, G., Gervasi, M., Limonta, A., Zannoni, M., Piccirillo, L., and Tucker, C.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The COSmic Monopole Observer (COSMO) is an experiment to measure low-level spectral distortions in the isotropic component of the Cosmic Microwave Background (CMB). Deviations from a pure blackbody spectrum are expected at low level ($<$ 1 ppm) due to several astrophysical and cosmological phenomena, and promise to provide important independent information on the early and late phases of the universe. They have not been detected yet, due to the extreme accuracy required, the best upper limits being still those from the COBE-FIRAS mission. COSMO is based on a cryogenic differential Fourier Transform Spectrometer, measuring the spectral brightness difference between the sky and an accurate cryogenic blackbody. The first implementation of COSMO, funded by the Italian PRIN and PNRA programs, will operate from the Concordia station at Dome-C, in Antarctica, and will take advantage of a fast sky-dip technique to get rid of atmospheric emission and its fluctuations, separating them from the monopole component of the sky brightness. Here we describe the instrument design, its capabilities, the current status. We also discuss its subsequent implementation in a balloon-flight, which has been studied within the COSMOS program of the Italian Space Agency., Comment: To be published on the proceedings of the 16th Marcel Grossmann Meeting on Recent Developments in Theoretical and Experimental General Relativity, Astrophysics and Relativistic Field Theories (MG16) - 5-9 July 2021. Online Conference, Italy - http://www.icra.it/mg/mg16/

Published
2021

6. Measuring CMB Spectral Distortions from Antarctica with COSMO: Blackbody Calibrator Design and Performance Forecast

Author

Mele, L., Battistelli, E. S., de Bernardis, P., Bersanelli, M., Columbro, F., Coppi, G., Coppolecchia, A., D’Alessandro, G., De Petris, M., Franceschet, C., Gervasi, M., Lamagna, L., Limonta, A., Manzan, E., Marchitelli, E., Masi, S., Mennella, A., Nati, F., Paiella, A., Pettinari, G., Piacentini, F., Piccirillo, L., Pisano, G., Realini, S., Tucker, C., and Zannoni, M.

Published
2022
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7. Measuring the CMB primordial B-modes with Bolometric Interferometry

Author

Mennella A., Ade P., Almela A., Amico G., Arnaldi L.H., Aumont J., Banfi S., Battistelli E.S., Bélier B., Bergé L., Bernard J.-Ph., Bersanelli M., Bonaparte J., Bonilla J.D., Bunn E., Buzi D., Cacciotti F., Camilieri D., Cavaliere F., Chanial P., Chapron C., Colombo L., Columbro F., Coppolecchia A., Costanza M.B., D’Alessandro G., de Bernardis P., De Gasperis G., De Leo M., De Petris M., Del Castillo N., Dheilly S., Etchegoyen A., Ferazzoli S., Ferreyro L.P., Franceschet C., Lerena M.M. Gamboa, Ganga K., García B., Redondo M.E. García, Gayer D., Geria J.M., Gervasi M., Giard M., Gilles V., Berisso M. Gómez, Gonzalez M., Gradziel M., Grandsire L., Hamilton J.-Ch., Hampel M.R., Isopi G., Kaplan J., Lamagna L., Lazarte F., Loucatos S., Maffei B., Mancilla A., Mandelli S., Manzan E., Marchitelli E., Marnieros S., Marty W., Masi S., May A., Maya J., McCulloch M., Mele L., Melo D., Mirón-Granese N., Montier L., Mousset L., Müller N., Nati F., O’Sullivan C., Paiella A., Pajot F., Paradiso S., Pascale E., Passerini A., Pelosi A., Perciballi M., Pezzotta F., Piacentini F., Piat M., Piccirillo L., Pisano G., Platino M., Polenta G., Prêle D., Rambaud D., Ramos G., Rasztocky E., Régnier M., Reyes C., Rodríguez F., Rodríguez C.A., Romero G.E., Salum J.M., Schillaci A., Scóccola C., Stankowiak G., Tartari A., Thermeau J.-P., Timbie P., Tomasi M., Torchinsky S., Tucker G., Tucker C., Vacher L., Voisin F., Wright M., Zannoni M., and Zullo A.

Subjects
Physics, QC1-999
Abstract

The Q&U Bolometric Interferometer for Cosmology (QL’BIC) is the first bolometric interferometer designed to measure the primordial B-mode polarization of the Cosmic Microwave Background (CMB). Bolometric interferometry is a novel technique that combines the sensitivity of bolometric detectors with the control of systematic effects that is typical of interferometry, both key features in the quest for the faint signal of the primordial B-modes. A unique feature is the so-called “spectral imaging”, i.e., the ability to recover the sky signal in several sub-bands within the physical band during data analysis. This feature provides an in-band spectral resolution of ∆v/v ~ 0.04 that is unattainable by a traditional imager. This is a key tool for controlling the Galactic foregrounds contamination. In this paper, we describe the principles of bolometric interferometry, the current status of the QU BIC experiment and future prospects.

Published
2024
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8. Design and performance test of a modular readout electronic for the kinetic inductance detectors for the COSMO experiment based on commercial components

Author

Zmuidzinas, J, Gao, JR, Conenna, G, Limonta, A, Meinardi, S, Passerini, A, Coppi, G, Gervasi, M, Nati, F, Zannoni, M, Albano, L, Battistelli, E, Bersanelli, M, Boussaha, F, Cacciotti, F, Capponi, A, Columbro, F, Coppolecchia, A, D'Alessandro, G, de Bernardis, P, De Gasperis, G, de Petris, M, Franceschet, C, Isopi, G, Lamagna, L, Manzan, E, Marchitelli, E, Masi, S, Mennella, A, Montonati, F, Occhiuzzi, A, Paiella, A, Pettinari, G, Piacentini, F, Piccirillo, L, Pisano, G, Tartari, A, Tucker, C, Conenna, Giulia, Limonta, Andrea, Meinardi, Stefano, Passerini, Andrea, Coppi, Gabriele, Gervasi, Massimo, Nati, Federico, Zannoni, Mario, Albano, Lorenzo, Battistelli, Elia S., Bersanelli, Marco, Boussaha, Faouzi M., Cacciotti, Federico, Capponi, Alessandro, Columbro, Fabio, Coppolecchia, Alessandro, D'Alessandro, Giuseppe, de Bernardis, Paolo, De Gasperis, Giancarlo, de Petris, Marco, Franceschet, Cristian, Isopi, Giovanni, Lamagna, Luca, Manzan, Elenia, Marchitelli, Elisabetta, Masi, Silvia, Mennella, Aniello, Montonati, Filippo, Occhiuzzi, Andrea, Paiella, Alessandro, Pettinari, Giorgio, Piacentini, Francesco, Piccirillo, Lucio, Pisano, Gampaolo, Tartari, Andrea, Tucker, Carole, Zmuidzinas, J, Gao, JR, Conenna, G, Limonta, A, Meinardi, S, Passerini, A, Coppi, G, Gervasi, M, Nati, F, Zannoni, M, Albano, L, Battistelli, E, Bersanelli, M, Boussaha, F, Cacciotti, F, Capponi, A, Columbro, F, Coppolecchia, A, D'Alessandro, G, de Bernardis, P, De Gasperis, G, de Petris, M, Franceschet, C, Isopi, G, Lamagna, L, Manzan, E, Marchitelli, E, Masi, S, Mennella, A, Montonati, F, Occhiuzzi, A, Paiella, A, Pettinari, G, Piacentini, F, Piccirillo, L, Pisano, G, Tartari, A, Tucker, C, Conenna, Giulia, Limonta, Andrea, Meinardi, Stefano, Passerini, Andrea, Coppi, Gabriele, Gervasi, Massimo, Nati, Federico, Zannoni, Mario, Albano, Lorenzo, Battistelli, Elia S., Bersanelli, Marco, Boussaha, Faouzi M., Cacciotti, Federico, Capponi, Alessandro, Columbro, Fabio, Coppolecchia, Alessandro, D'Alessandro, Giuseppe, de Bernardis, Paolo, De Gasperis, Giancarlo, de Petris, Marco, Franceschet, Cristian, Isopi, Giovanni, Lamagna, Luca, Manzan, Elenia, Marchitelli, Elisabetta, Masi, Silvia, Mennella, Aniello, Montonati, Filippo, Occhiuzzi, Andrea, Paiella, Alessandro, Pettinari, Giorgio, Piacentini, Francesco, Piccirillo, Lucio, Pisano, Gampaolo, Tartari, Andrea, and Tucker, Carole

Published
2024

9. Measuring the CMB spectral distortions with COSMO: the multi-mode antenna system

Author

Zmuidzinas, Jonas, Manzan, E, Albano, L, Franceschet, C, Battistelli, E, De Bernardis, P, Bersanelli, M, Cacciotti, F, Capponi, A, Columbro, F, Conenna, G, Coppi, G, Coppolecchia, A, D'Alessandro, G, De Gasperis, G, De Petris, M, Gervasi, M, Isopi, G, Lamagna, L, Limonta, A, Marchitelli, E, Masi, S, Mennella, A, Montonati, F, Nati, F, Occhiuzzi, A, Paiella, A, Pettinari, G, Piacentini, F, Piccirillo, L, Pisano, G, Tucker, C, Zannoni, M, Manzan, Elenia, Albano, Lorenzo, Franceschet, Cristian, Battistelli, Elia S., De Bernardis, Paolo, Bersanelli, Marco, Cacciotti, Federico, Capponi, Alessandro, Columbro, Fabio, Conenna, Giulia, Coppi, Gabriele, Coppolecchia, Alessandro, D'Alessandro, Giuseppe, De Gasperis, Giancarlo, De Petris, Marco, Gervasi, Massimo, Isopi, Giovanni, Lamagna, Luca, Limonta, Andrea, Marchitelli, Elisabetta, Masi, Silvia, Mennella, Aniello, Montonati, Filippo, Nati, Federico, Occhiuzzi, Andrea, Paiella, Alessandro, Pettinari, Giorgio, Piacentini, Francesco, Piccirillo, Lucio, Pisano, Giampaolo, Tucker, Carole, Zannoni, Mario, Zmuidzinas, Jonas, Manzan, E, Albano, L, Franceschet, C, Battistelli, E, De Bernardis, P, Bersanelli, M, Cacciotti, F, Capponi, A, Columbro, F, Conenna, G, Coppi, G, Coppolecchia, A, D'Alessandro, G, De Gasperis, G, De Petris, M, Gervasi, M, Isopi, G, Lamagna, L, Limonta, A, Marchitelli, E, Masi, S, Mennella, A, Montonati, F, Nati, F, Occhiuzzi, A, Paiella, A, Pettinari, G, Piacentini, F, Piccirillo, L, Pisano, G, Tucker, C, Zannoni, M, Manzan, Elenia, Albano, Lorenzo, Franceschet, Cristian, Battistelli, Elia S., De Bernardis, Paolo, Bersanelli, Marco, Cacciotti, Federico, Capponi, Alessandro, Columbro, Fabio, Conenna, Giulia, Coppi, Gabriele, Coppolecchia, Alessandro, D'Alessandro, Giuseppe, De Gasperis, Giancarlo, De Petris, Marco, Gervasi, Massimo, Isopi, Giovanni, Lamagna, Luca, Limonta, Andrea, Marchitelli, Elisabetta, Masi, Silvia, Mennella, Aniello, Montonati, Filippo, Nati, Federico, Occhiuzzi, Andrea, Paiella, Alessandro, Pettinari, Giorgio, Piacentini, Francesco, Piccirillo, Lucio, Pisano, Giampaolo, Tucker, Carole, and Zannoni, Mario

Published
2024

10. Measuring the CMB spectral distortions with COSMO: the multimode antenna system

Author

Zmuidzinas, Jonas, Gao, Jian-Rong, Manzan, E., Albano, L., Franceschet, C., Battistelli, E., De Bernardis, P., Bersanelli, M., Cacciotti, F., Capponi, A., Columbro, F., Conenna, G., Coppi, G., Coppolecchia, A., D'Alessandro, G., De Gasperis, G., De Petris, M., Gervasi, M., Isopi, G., Lamagna, L., Limonta, A., Marchitelli, E., Masi, S., Mennella, A., Montonati, F., Nati, F., Occhiuzzi, A., Paiella, A., Pettinari, G., Piacentini, F., Piccirillo, L., Pisano, G., Tucker, C., and Zannoni, M.

Published
2024
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11. The COSmic Monopole Observer (COSMO)

Author

Masi, S., primary, Battistelli, E., additional, de Bernardis, P., additional, Columbro, F., additional, Coppolecchia, A., additional, D’Alessandro, G., additional, De Petris, M., additional, Lamagna, L., additional, Marchitelli, E., additional, Mele, L., additional, Paiella, A., additional, Piacentini, F., additional, Pisano, G., additional, Bersanelli, M., additional, Franceschet, C., additional, Manzan, E., additional, Mennella, D., additional, Realini, S., additional, Cibella, S., additional, Martini, F., additional, Pettinari, G., additional, Coppi, G., additional, Gervasi, M., additional, Limonta, A., additional, Zannoni, M., additional, Piccirillo, L., additional, and Tucker, C., additional

Published
2023
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13. The LiteBIRD mission to explore cosmic inflation

Author

Coyle, Laura E., Matsuura, Shuji, Perrin, Marshall D., Ghigna, T., Adler, A., Aizawa, K., Akamatsu, H., Akizawa, R., Allys, E., Anand, A., Aumont, J., Austermann, J., Azzoni, S., Baccigalupi, C., Ballardini, M., Banday, A., Barreiro, R., Bartolo, N., Basak, S., Basyrov, A., Beckman, S., Bersanelli, M., Bortolami, M., Bouchet, F., Brinckmann, T., Campeti, P., Carinos, E., Carones, A., Casas, F. J., Cheung, K., Chinone, Y., Clermont, L., Columbro, F., Coppolecchia, A., Curtis, D., de Bernardis, P., de Haan, T., de la Hoz, E., De Petris, M., Della Torre, S., Delle Monache, G., Di Giorgi, E., Dickinson, C., Diego-Palazuelos, P., Díaz García, J. J., Dobbs, M., Dotani, T., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Farias, N., Ferreira, E., Franceschet, C., Fuskeland, U., Galloni, G., Galloway, M., Ganga, K., Gerbino, M., Gervasi, M., Génova-Santos, R. T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., González González, R., Grandsire, L., Gruppuso, A., Halverson, N., Hargrave, P., Harper, S. E., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Herranz, D., Hivon, E., Hlozek, R., Hoang, T. D., Hubmayr, J., Ichiki, K., Ikuma, K., Ishino, H., Jaehnig, G., Jost, B., Kohri, K., Konishi, K., Lamagna, L., Lattanzi, M., Leloup, C., Levrier, F., Lanoppan, A., Luzzi, G., Macias-Perez, J., Maffei, B., Marchitelli, E., Martínez-González, E., Masi, S., Matarrese, S., Matsumura, T., Micheli, S., Migliaccio, M., Monelli, M., Montier, L., Morgante, G., Mousset, L., Nagano, Y., Nagata, R., Natoli, P., Novelli, A., Noviello, F., Obata, I., Occhiuzzi, A., Odagiri, K., Omae, R., Pagano, L., Paiella, A., Paoletti, D., Pascual-Cisneros, G., Patanchon, G., Pavlidou, V., Piacentini, F., Piat, M., Piccirilli, G., Pinchera, M., Pisano, G., Porcelli, L., Raffuzzi, N., Raum, C., Remazeilles, M., Ritacco, A., Rubino-Martin, J., Ruiz-Granda, M., Sakurai, Y., Savini, G., Scott, D., Sekimoto, Y., Shiraishi, M., Signorelli, G., Stever, S. L., Sullivan, R., Suzuki, A., Takaku, R., Takakura, H., Takakura, S., Takase, Y., Tartari, A., Tassis, K., Thompson, K. L., Tomasi, M., Tristram, M., Tucker, C., Vacher, L., van Tent, B., Vielva, P., Watanuki, K., Wehus, I. K., Westbrook, B., Weymann-Despres, G., Winter, B., Wollack, E. J., Zacchei, A., Zannoni, M., and Zhou, Y.

Published
2024
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14. Design and performance test of a modular readout electronic for the kinetic inductance detectors for the COSMO experiment based on commercial components

Author

Zmuidzinas, Jonas, Gao, Jian-Rong, Conenna, G., Limonta, A., Meinardi, S., Passerini, A., Coppi, G., Gervasi, M., Nati, F., Zannoni, M., Albano, L., Battistelli, E., Bersanelli, M., Boussaha, F., Cacciotti, F., Capponi, A., Columbro, F., Coppolecchia, A., D'Alessandro, G., de Bernardis, P., De Gasperis, G., de Petris, M., Franceschet, C., Isopi, G., Lamagna, L., Manzan, E., Marchitelli, E., Masi, S., Mennella, A., Montonati, F., Occhiuzzi, A., Paiella, A., Pettinari, G., Piacentini, F., Piccirillo, L., Pisano, G., Tartari, A., and Tucker, C.

Published
2024
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16. Prevention of serious vascular events by aspirin amongst patients with peripheral arterial disease: randomized, double-blind trial

Author

Fabris, F., Pilger, E., Pabst, E., Kostner, G., Wautrecht, J. C., Baitsch, G., Breddin, K., Diehm, C., Podhaisky, H., Taute, B. M., Diamantoupolos, E. J., Aimar, T., Alari, G., Albano, S., Altamura, N., Arosio, E., Bortolon, M., Caccia, R., Carotta, M., Carzaniga, G., Catalano, M., Contini, P., Difolca, A., Dore, M., Falaschi, F., Franchini, B., Frare, C., Frascisco, M., Giansante, C., Giona, E., Giubbolini, M., Lucarelli, F., Marchitelli, E., Marcialis, M. R., Martignoni, A., Melillo, E., Minola, M., Monetti, D., Nenci, G., Paolicelli, M., Pasqualini, L., Perilli, E., Pettina, G., Poli, L., Radicchia, S., Rossi, M., Scandale, G., Scondotto, G., Sergi, D., Setacci, C., Spada, S., Todini, A. R., Vaudo, G., Verlato, F., Visona, A., Zannoni, M., Bielawiec, M., Jawien, A., Meissner, A., Michalak, J., Nizankowski, R., Wandzilak, M., Avram, J. A., Avram, R., Hancu, N., Marian, A., Marian, I., Murariu, M., Negrisanu, G., Olinic, D., Olinic, N., Trambitas, R., Veresiu, I., Victoria, I., Kozak, M., Mavri, A., Bahi, J. S., Bahi, P. S., Brunkwall, J., and Gallino, A.

Subjects
Male, medicine.medical_specialty, Settore MED/09 - Medicina Interna, Placebo, law.invention, Double-Blind Method, Randomized controlled trial, Ischemia, law, Internal medicine, Internal Medicine, medicine, Humans, Myocardial infarction, Stroke, Aged, Angiology, Peripheral Vascular Diseases, Leg, Aspirin, Vascular disease, business.industry, Antioxidant vitamins, Peripheral arterial disease, Prevention, medicine.disease, Surgery, Clinical trial, Treatment Outcome, Female, business, Platelet Aggregation Inhibitors, medicine.drug
Abstract

OBJECTIVE: To assess the prophylactic efficacy of aspirin and a high-dose antioxidant vitamin combination in patients with peripheral arterial disease (PAD) in terms of reduction of the risk of a first vascular event (myocardial infarction, stroke, vascular death) and critical limb ischaemia. DESIGN: Randomized, placebo-controlled, double-blind clinical trial with 2 x 2 factorial design. SETTING: Thirty-seven European angiology/vascular medicine units. SUBJECTS: A total of 366 outpatients with stage I-II PAD documented by angiography or ultrasound, with ankle/brachial index

Published
2007

17. Prevention of serious vascular events by aspirin amongst patients with peripheral arterial disease: a randomized, double-blind trial

Author

Pilger, E, Pabst, E, Kostner, G, Wautrecht, Jc, Baitsch, G, Breddin, K, Diehm, C, Podhaisky, H, Taute, Bm, Diamantoupolos, Ej, Aimar, T, Alari, G, Albano, S, Altamura, N, Arosio, E, Bortolon, M, Caccia, R, Carotta, M, Carzaniga, G, Catalano, M, Contini, P, Difolca, A, Dore, M, Fabris, F, Falaschi, F, Franchini, B, Frare, C, Frascisco, M, Giansante, C, Giona, E, Giubbolini, M, Lucarelli, F, Marchitelli, E, Marcialis, Mr, Martignoni, A, Melillo, E, Minola, M, Monetti, D, Nenci, G, Paolicelli, M, Pasqualini, Leonella, Perilli, E, Pettina, G, Poli, L, Radicchia, S, Rossi, M, Scandale, G, Scondotto, G, Sergi, D, Setacci, C, Spada, S, Todini, Ar, Vaudo, Gaetano, Verlato, F, Visona, A, Zannoni, M, Bielawiec, M, Jawien, A, Meissner, A, Michalak, J, Nizankowski, R, Wandzilak, M, Avram, Ja, Avram, R, Hancu, N, Marian, A, Marian, I, Murariu, M, Negrisanu, G, Olinic, D, Olinic, N, Trambitas, R, Veresiu, I, Victoria, I, Kozak, M, Mavri, A, Bahi, Js, Bahi, Ps, Brunkwall, J, and Gallino, A.

Published
2007

18. Effects of defibrotide in patients with chronic deep insufficiency - The PROVEDIS study

Author

Coccheri, S, Andreozzi, Gm, D'Addato, M, Gensini, Gf, Garibaldi, O, Signorelli, S, Di Pino, L, Belardi, P, Grana, A, Belcaro, G, Incandela, G, Laurora, G, Biasi, Gm, Bellucci, M, Careggi, P, Innocenti, Aa, Frosini, P, Borromeo, Osc, Bonfardeci, G, Cimminiello, C, Arpaia, G, Bracale, Cg, Selvetella, L, De Rosa, V, Martini, L, Coppi, G, Marra, F, Stella, A, Mirelli, M, Donini, I, Viaggi, R, Cataldi, A, Ferrero, S, Dorigo, B, Cameli, A, Licata, G, Pinto, A, Mannarino, Elmo, Pasqualini, Leonella, Vaudo, Gaetano, Marchitelli, E, Pepe, R, Novo, S, Tantillo, R, Nuzzaci, G, Righi, D, Pitzus, F, Manconi, E, Ponzio, F, Rizzon, P, Ciccone, M, Campagna, Mg, Scondotto, G, Aloisi, D, Valitutti, P, and Fornino, G.

Published
2004

20. Femoral Catheters: Safety and Efficacy in Peripheral Blood Stem Cell Collection

Author

Adorno, G., primary, Zinno, F., additional, Bruno, A., additional, Lanti, A., additional, Ballatore, G., additional, Masi, M., additional, Cudillo, L., additional, Del Poeta, G., additional, Riccitelli, A., additional, Del Principe, M.I., additional, Pepe, R., additional, Marchitelli, E., additional, Morosetti, M., additional, Meloni, C., additional, Isacchi, G., additional, and Amadori, S., additional

Published
1999
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22. Biological effects of a software-controlled voltage pulse generator (PhyBack PBK-2C) on the release of vascular endothelial growth factor (VEGF)

Author

Patrizia Ferroni, Roselli, M., Guadagni, F., Martini, F., Mariotti, S., Marchitelli, E., and Cipriani, C.

Subjects
Male, Vascular Endothelial Growth Factor A, Peripheral Vascular Diseases, Tumor Necrosis Factor-alpha, Settore MED/06 - Oncologia Medica, Pilot Projects, Middle Aged, Nitric Oxide, Electric Stimulation, Kinetics, Solubility, Italy, Equipment and Supplies, Humans, Cytokines, Female, Software, Aged, E-Selectin, Algorithms

25. The COSmic Monopole Observer (COSMO)

Author

Masi, S., Battistelli, E., de Bernardis, P., Columbro, F., Coppolecchia, A., D'Alessandro, G., De Petris, M., Lamagna, L., Marchitelli, E., Mele, L., Paiella, A., Piacentini, F., Pisano, G., Bersanelli, M., Franceschet, C., Manzan, E., Mennella, D., Realini, S., Cibella, S., Martini, F., Pettinari, G., Coppi, G., Gervasi, M., Limonta, A., Zannoni, M., Piccirillo, L., Tucker, C., Masi, S., Battistelli, E., de Bernardis, P., Columbro, F., Coppolecchia, A., D'Alessandro, G., De Petris, M., Lamagna, L., Marchitelli, E., Mele, L., Paiella, A., Piacentini, F., Pisano, G., Bersanelli, M., Franceschet, C., Manzan, E., Mennella, D., Realini, S., Cibella, S., Martini, F., Pettinari, G., Coppi, G., Gervasi, M., Limonta, A., Zannoni, M., Piccirillo, L., and Tucker, C.

Abstract

The COSmic Monopole Observer (COSMO) is an experiment to measure low-level spectral distortions in the isotropic component of the Cosmic Microwave Background (CMB). Deviations from a pure blackbody spectrum are expected at low level (< 1 ppm) due to several astrophysical and cosmological phenomena, and promise to provide important independent information on the early and late phases of the universe. They have not been detected yet, due to the extreme accuracy required, the best upper limits being still those from the COBE-FIRAS mission. COSMO is based on a cryogenic differential Fourier Transform Spectrometer, measuring the spectral brightness difference between the sky and an accurate cryogenic blackbody. The first implementation of COSMO, funded by the Italian PRIN and PNRA programs, will operate from the Concordia station at Dome-C, in Antarctica, and will take advantage of a fast sky-dip technique to get rid of atmospheric emission and its fluctuations, separating them from the monopole component of the sky brightness. Here we describe the instrument design, its capabilities, the current status. We also discuss its subsequent implementation in a balloon-flight, which has been studied within the COSMOS program of the Italian Space Agency.

26. Measuring CMB Spectral Distortions from Antarctica with COSMO: Blackbody Calibrator Design and Performance Forecast

Author

L. Mele, E. S. Battistelli, P. de Bernardis, M. Bersanelli, F. Columbro, G. Coppi, A. Coppolecchia, G. D’Alessandro, M. De Petris, C. Franceschet, M. Gervasi, L. Lamagna, A. Limonta, E. Manzan, E. Marchitelli, S. Masi, A. Mennella, F. Nati, A. Paiella, G. Pettinari, F. Piacentini, L. Piccirillo, G. Pisano, S. Realini, C. Tucker, M. Zannoni, Mele, L, Battistelli, E, de Bernardis, P, Bersanelli, M, Columbro, F, Coppi, G, Coppolecchia, A, D'Alessandro, G, De Petris, M, Franceschet, C, Gervasi, M, Lamagna, L, Limonta, A, Manzan, E, Marchitelli, E, Masi, S, Mennella, A, Nati, F, Paiella, A, Pettinari, G, Piacentini, F, Piccirillo, L, Pisano, G, Realini, S, Tucker, C, and Zannoni, M

Subjects
spectral distortions, General Materials Science, Blackbody, cosmology, Condensed Matter Physics, Spectral distortion, Atomic and Molecular Physics, and Optics, Cosmology, Spectral distortions
Abstract

COSMO is a ground-based instrument to measure the spectral distortions (SD) of the Cosmic Microwave Background (CMB). In this paper, we present preliminary results of electromagnetic simulations of its reference blackbody calibrator. HFSS simulations provide a calibrator reflection coefficient of $$R\sim 10^{-6}$$ R ∼ 10 - 6 , corresponding to an emissivity $$\epsilon =1-R=0.999999$$ ϵ = 1 - R = 0.999999 . We also provide a forecast for the instrument performance by using an ILC-based simulation. We show that COSMO can extract the isotropic Comptonization parameter (modeled as $$|y|=1.77 \cdot 10^{-6}$$ | y | = 1.77 · 10 - 6 ) as $$|y|=(1.79\pm 0.19)\cdot 10^{-6}$$ | y | = ( 1.79 ± 0.19 ) · 10 - 6 , in the presence of the main Galactic foreground (thermal dust) and of CMB anisotropies, and assuming perfect atmospheric emission removal.

Published
2022

27. Kalèdo, a new educational board-game, gives nutritional rudiments and encourages healthy eating in children: a pilot cluster randomized trial

Author

Bruno De Luca, Alessandro Viggiano, Maria Ena Baccari, Ida Madeo, S. Amaro, Emanuela Viggiano, Elena Marchitelli, Sunil Deepak, Marcellino Monda, Anna Di Costanzo, Maddalena Raia, Andrea Viggiano, Amaro, S, Viggiano, Alessandro, Di Costanzo, A, Madeo, I, Viggiano, A, Baccari, Me, Marchitelli, E, Raia, M, Viggiano, E, Deepak, S, Monda, Marcellino, and De Luca, B.

Subjects
Questionnaires, Male, Research design, Gerontology, Health Knowledge, Attitudes, Practice, Pediatrics, Nutrition Education, Health Behavior, Pilot Projects, Overweight, Body Mass Index, law.invention, Eating, Randomized controlled trial, law, Surveys and Questionnaires, Cluster Analysis, Child, Health Education, Practice, Anthropometry, Health Knowledge, Italy, Research Design, Regression Analysis, epidemiology, Female, Health education, medicine.symptom, medicine.medical_specialty, Educational measurement, Adolescent, Diet therapy, European Continental Ancestry Group, Health Promotion, Motor Activity, White People, medicine, Humans, Analysis of Variance, Random assignment, business.industry, Reproducibility of Results, Feeding Behavior, Attitudes, Adolescent, Analysis of Variance, Anthropometry, Body Mass Index, Child, Cluster Analysis, Eating, Educational Measurement, European Continental Ancestry Group, Female, Follow-Up Studies, Food Habits, Health Behavior, Health Education, Health Knowledge, Practice, Health Promotion, Humans, Italy, epidemiology, Male, Motor Activity, Pilot Projects, Questionnaires, Regression Analysis, Reproducibility of Results, Research Design, Pediatrics, Perinatology and Child Health, Food Habits, Educational Measurement, business, Follow-Up Studies
Abstract

Introduction: Prevention of obesity and overweight is an important target for health promotion. Early prevention requires an intervention during childhood and adolescence. At these stages, the game could be an appropriate means to teach nutrition knowledge and to influence dietary behaviour. To this end, the authors developed Kaledo, a new board-game. Objective: The aim of the present study was to test the efficacy of Kaledo on changes in nutrition knowledge and dietary behaviour in a pilot study conducted in three middle schools in Naples, Italy. Materials and Methods: A simple two-group design (treatment and control) with pre- and post-assessment was employed. The classroom was the unit of recruitment and random assignment to groups. All students (307) in the participating schools were invited to participate. Data analysis was performed on 241 subjects. During 24 weeks, a group of 153 children from 8 classrooms (11-14 year old Caucasian subjects; 78 male, 75 female) was involved in 15-30 minute-long play sessions once a week. A questionnaire was given to the participants at the beginning and at the end of the study to evaluate nutrition knowledge (31 questions), physical activity (8 questions) and food intake (34 questions). Anthropometric measurements were also carried out. A second group of 88 children from 5 classrooms (same age and ethnicity; 55 male, 33 female) was investigated at the same times with the same questionnaire and anthropometric measures but they did not receive any play sessions with Kaledo. Observation: Children playing Kaledo showed a significant increase in nutrition knowledge (p < 0.05) and in weekly vegetable intake (p < 0.01) with respect to the control. Conclusion: The results suggest that Kaledo could be an effective instrument to teach children about healthy diet. More research is needed to study the long term effect of this intervention.

Published
2006

28. Kalèdo, a new educational board-game, gives nutritional rudiments and encourages healthy eating in children: a pilot cluster randomized trial.

Author

Amaro S, Viggiano A, Di Costanzo A, Madeo I, Viggiano A, Baccari ME, Marchitelli E, Raia M, Viggiano E, Deepak S, Monda M, and De Luca B

Subjects
Adolescent, Analysis of Variance, Anthropometry, Body Mass Index, Child, Cluster Analysis, Eating, Educational Measurement, Female, Follow-Up Studies, Health Knowledge, Attitudes, Practice, Health Promotion, Humans, Italy epidemiology, Male, Motor Activity, Pilot Projects, Regression Analysis, Reproducibility of Results, Research Design, Surveys and Questionnaires, White People, Feeding Behavior, Health Behavior, Health Education
Abstract

Introduction: Prevention of obesity and overweight is an important target for health promotion. Early prevention requires an intervention during childhood and adolescence. At these stages, the game could be an appropriate means to teach nutrition knowledge and to influence dietary behaviour. To this end, the authors developed Kalèdo, a new board-game., Objective: The aim of the present study was to test the efficacy of Kalèdo on changes in nutrition knowledge and dietary behaviour in a pilot study conducted in three middle schools in Naples, Italy., Materials and Methods: A simple two-group design (treatment and control) with pre- and post-assessment was employed. The classroom was the unit of recruitment and random assignment to groups. All students (307) in the participating schools were invited to participate. Data analysis was performed on 241 subjects. During 24 weeks, a group of 153 children from 8 classrooms (11-14 year old Caucasian subjects; 78 male, 75 female) was involved in 15-30 minute-long play sessions once a week. A questionnaire was given to the participants at the beginning and at the end of the study to evaluate nutrition knowledge (31 questions), physical activity (8 questions) and food intake (34 questions). Anthropometric measurements were also carried out. A second group of 88 children from 5 classrooms (same age and ethnicity; 55 male, 33 female) was investigated at the same times with the same questionnaire and anthropometric measures but they did not receive any play sessions with Kalèdo., Observation: Children playing Kalèdo showed a significant increase in nutrition knowledge (p<0.05) and in weekly vegetable intake (p<0.01) with respect to the control., Conclusion: The results suggest that Kalèdo could be an effective instrument to teach children about healthy diet. More research is needed to study the long term effect of this intervention.

Published
2006
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29. Biological effects of a software-controlled voltage pulse generator (PhyBack PBK-2C) on the release of vascular endothelial growth factor (VEGF).

Author

Ferroni P, Roselli M, Guadagni F, Martini F, Mariotti S, Marchitelli E, and Cipriani C

Subjects
Aged, Algorithms, Cytokines metabolism, E-Selectin blood, Electric Stimulation instrumentation, Female, Humans, Italy, Kinetics, Male, Middle Aged, Nitric Oxide biosynthesis, Peripheral Vascular Diseases physiopathology, Pilot Projects, Solubility, Tumor Necrosis Factor-alpha metabolism, Vascular Endothelial Growth Factor A blood, Electric Stimulation methods, Equipment and Supplies, Peripheral Vascular Diseases therapy, Software, Vascular Endothelial Growth Factor A metabolism
Abstract

Background: Electrical stimulation (ES) may induce vascular permeability and physiological angiogenesis. ES of rat muscles significantly increases the microvessel density and vascular endothelial growth factor (VEGF) protein levels. Thus, a pilot study was designed to analyze the effects of low-voltage electric impulses on VEGF levels in patients with dystrophic ulcers., Materials and Methods: Circulating VEGF levels were analyzed in 9 patients undergoing an ES session with low voltage software-controlled impulses applied through topical transducers (1-9 micros width, 1-420-Hz frequency and 30-120 V strength-100 microA max)., Results: The session was accompanied by a peak of circulating VEGF (3-10 min from start) in all 9 patients, which was preceded by a rise of TNF-alpha (2-min) and was independently associated with soluble E-selectin levels. Nitric oxide generation was significantly improved on the day after treatment. No hemostatic activation or sustained inflammatory reaction were observed., Conclusion: ES may represent a safe method for augmenting VEGF-mediated vascular protection, either directly or by induction of NO.

Published
2005

30. Different circumstances of the first venous thromboembolism among younger or older heterozygous carriers of the G20210A polymorphism in the prothrombin gene.

Author

De Stefano V, Rossi E, Paciaroni K, D'Orazio A, Cina G, Marchitelli E, Pepe R, and Leone G

Subjects
Adult, Age Factors, Aged, Aged, 80 and over, Case-Control Studies, Female, Heterozygote, Humans, Italy epidemiology, Male, Middle Aged, Polymorphism, Single Nucleotide, Prothrombin genetics, Thromboembolism genetics, Venous Thrombosis genetics
Abstract

Background and Objectives: The G20210A polymorphism in the prothrombin gene is a common cause of inherited thrombophilia. Scarce information is available about the circumstances of the heralding thrombotic manifestation at different ages. The aim of this study was to determine the risk of spontaneous or secondary venous thromboembolism (VTE) among younger and older carriers of the G20210A prothrombin polymorphism., Design and Methods: We performed a case-control study, investigating 650 patients with a first objectively documented deep venous thrombosis of the legs or pulmonary embolism and 703 individuals with no history of vascular disease. In all of them we carried out laboratory screening for antithrombin III, protein C and protein S deficiencies, and for the presence of the factor V Leiden and the G20210A prothrombin polymorphisms., Results: After adjustment for other inherited causes of thrombophilia (deficiency of antithrombin III, protein C or S, factor V Leiden) the overall risk for VTE associated with the prothrombin polymorphism was 3.4 times higher than in the controls (95% CI, 2.0 to 5.8). Stratification according to the age and to the circumstances of the first event revealed an increased risk of spontaneous VTE only among the patients older than 45 years in comparison with age-matched controls (odds ratio 4.4, 95% CI 1.8 to 10.6); among the younger individuals the risk was increased for secondary VTE (odds ratio 4.8, 95% CI, 2.3 to 9.8) but not for spontaneous VTE., Interpretation and Conclusions: The clinical penetrance of the thrombotic tendency associated with the G20210A prothrombin polymorphism is more expressed in the presence of a circumstantial risk factor (oral contraceptives, pregnancy, surgery, trauma) and in the presence of older age, which acts as an additional circumstantial risk factor. Accordingly, such situations should not discourage from carrying out laboratory screening.

Published
2003

32. Tolerability and clinical efficacy of desmin in the treatment of superficial thrombovaricophlebitis.

Author

Andreozzi GM, Signorelli S, Di Pino L, Martini R, Marchitelli E, Pinto A, Romeo S, Zamboni V, and Palazzini E

Subjects
Adult, Aged, Dermatan Sulfate adverse effects, Female, Fibrinolytic Agents adverse effects, Humans, Injections, Intramuscular, Injections, Subcutaneous, Male, Middle Aged, Molecular Weight, Thrombophlebitis complications, Dermatan Sulfate administration & dosage, Fibrinolytic Agents administration & dosage, Thrombophlebitis drug therapy, Varicose Veins complications
Abstract

Fifty-six patients with superficial thrombovaricophlebitis of the lower limbs were enrolled in an open and multicenter (4 centers) trial for a period of thirty days. Patients were randomly allocated to three treatment groups to receive a new low-molecular-weight dermatan sulfate (Desmin) at the dose, respectively, of 100 mg once daily by subcutaneous (SC) route, 100 mg twice a day SC, and 200 mg once daily by intramuscular (IM) route. The general and local tolerability and the clinical efficacy of the drug were evaluated by means of clinical, instrumental, and laboratory parameters. Desmin proved capable of effectively improving the symptoms of patients affected by thrombovaricophlebitis, inducing rapid regression by the tenth day of treatment. The daily dose of 200 mg (either SC or IM) was more effective than the 100 mg dose. The systemic tolerability of the drug, administered for the first time for one month, was extremely good, without significant variations in the relevant laboratory tests. Local tolerance (at the site of injection) of the drug was also good.

Published
1996
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34. [Migrating phlebitis: nosographic definition and clinical contribution].

Author

Bartolo M, Allegra C, and Marchitelli E

Subjects
Adult, Aged, Blood Platelet Disorders complications, Bronchitis complications, Female, Gastrointestinal Neoplasms complications, Hernia, Diaphragmatic complications, Humans, Infections complications, Male, Middle Aged, Splenectomy adverse effects, Thromboangiitis Obliterans complications, Arteriosclerosis Obliterans complications, Phlebitis etiology
Published
1967

38. [Phenomena of hemometakinesia in clinical practice].

Author

Marcacci W, Bartolo M, Marchitelli E, and Allegra C

Subjects
Female, Humans, Male, Middle Aged, Regional Blood Flow, Rheology, Vasodilator Agents adverse effects, Blood Circulation, Iliac Artery, Ischemia, Leg blood supply, Thrombosis
Published
1967

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