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1. Expansion of clonotypic T-cell populations in the peripheral blood of asymptomatic Gran Chaco Amerindians infected with HTLV-II

Author

Love, Jayne L., Marchioli, Carmine C., Dube, Syamalima, Bryz-Gornia, Virginia, Loughran, Thomas P., Jr., Glaser, Jordan B., Esteban, Eduardo, Feldman, Leonardo, Ferrer, Jorge F., and Poiesz, Bernard J.

Subjects
HTLV-II infections -- Genetic aspects, South American native peoples -- Health aspects, Health
Abstract

A genetic variant in human T-cells of South American Indians infected with human T-cell leukemia virus (HTLV-IIB) may indicate more progressive disease. These viruses have been associated with leukemia, autoimmune disorders, and neurodegenerative disease, and HTLV infection is endemic among Gran Chaco Amerindians in Paraguay and Argentina. Researchers performed genetic analysis of 30 HTLV-IIB-infected people and 30 uninfected people. HTLV-IIB infection was associated with V-beta clonotypic T-cell expansion, a finding which may be useful in developing more sensitive tests.

Published
1998

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