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4. Overcoming Chemoresistance in Cancer: The Promise of Crizotinib.

Author

Musa, Sanaa, Amara, Noor, Selawi, Adan, Wang, Junbiao, Marchini, Cristina, Agbarya, Abed, and Mahajna, Jamal

Subjects
THERAPEUTIC use of antineoplastic agents, PROTEIN metabolism, PROTEIN kinase inhibitors, DRUG resistance in cancer cells, THERAPEUTICS, CELL physiology, APOPTOSIS, DNA repair, TUMORS, DRUG synergism, PHARMACODYNAMICS
Abstract

Simple Summary: Cancer cells often become resistant to treatment, making it harder to fight the disease effectively. This resistance can happen due to genetic changes, proteins that pump out drugs, or the environment around the tumor. Crizotinib is a drug that helps overcome this resistance in certain lung cancers and lymphomas by targeting specific proteins. It can also break down a harmful protein found in some cancers. Researchers have found that combining crizotinib with other drugs can improve its effectiveness, especially for cancers with specific genetic mutations. Chemoresistance is a major obstacle in cancer treatment, often leading to disease progression and poor outcomes. It arises through various mechanisms such as genetic mutations, drug efflux pumps, enhanced DNA repair, and changes in the tumor microenvironment. These processes allow cancer cells to survive despite chemotherapy, underscoring the need for new strategies to overcome resistance and improve treatment efficacy. Crizotinib, a first-generation multi-target kinase inhibitor, is approved by the FDA for the treatment of ALK-positive or ROS1-positive non-small cell lung cancer (NSCLC), refractory inflammatory (ALK)-positive myofibroblastic tumors (IMTs) and relapsed/refractory ALK-positive anaplastic large cell lymphoma (ALCL). Crizotinib exists in two enantiomeric forms: (R)-crizotinib and its mirror image, (S)-crizotinib. It is assumed that the R-isomer is responsible for the carrying out various processes reviewed here The S-isomer, on the other hand, shows a strong inhibition of MTH1, an enzyme important for DNA repair mechanisms. Studies have shown that crizotinib is an effective multi-kinase inhibitor targeting various kinases such as c-Met, native/T315I Bcr/Abl, and JAK2. Its mechanism of action involves the competitive inhibition of ATP binding and allosteric inhibition, particularly at Bcr/Abl. Crizotinib showed synergistic effects when combined with the poly ADP ribose polymerase inhibitor (PARP), especially in ovarian cancer harboring BRCA gene mutations. In addition, crizotinib targets a critical vulnerability in many p53-mutated cancers. Unlike its wild-type counterpart, the p53 mutant promotes cancer cell survival. Crizotinib can cause the degradation of the p53 mutant, sensitizing these cancer cells to DNA-damaging substances and triggering apoptosis. Interestingly, other reports demonstrated that crizotinib exhibits anti-bacterial activity, targeting Gram-positive bacteria. Also, it is active against drug-resistant strains. In summary, crizotinib exerts anti-tumor effects through several mechanisms, including the inhibition of kinases and the restoration of drug sensitivity. The potential of crizotinib in combination therapies is emphasized, particularly in cancers with a high prevalence of the p53 mutant, such as triple-negative breast cancer (TNBC) and high-grade serous ovarian cancer (HGSOC). [ABSTRACT FROM AUTHOR]

Published
2024
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5. The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery.

Author

Cardarelli, Francesco, Digiacomo, Luca, Marchini, Cristina, Amici, Augusto, Salomone, Fabrizio, Fiume, Giuseppe, Rossetta, Alessandro, Gratton, Enrico, Pozzi, Daniela, and Caracciolo, Giulio

Subjects
CHO Cells, Cell Nucleus, Cytoplasm, Animals, Humans, Cricetulus, Lipids, DNA, Transfection, Biological Transport, Genetic Vectors, Genetic Therapy, Single Molecule Imaging, Genetics, Biotechnology, Generic Health Relevance, Biochemistry and Cell Biology, Other Physical Sciences
Abstract

Lipofectamine reagents are widely accepted as "gold-standard" for the safe delivery of exogenous DNA or RNA into cells. Despite this, a satisfactory mechanism-based explanation of their superior efficacy has remained mostly elusive thus far. Here we apply a straightforward combination of live cell imaging, single-particle tracking microscopy, and quantitative transfection-efficiency assays on live cells to unveil the intracellular trafficking mechanism of Lipofectamine/DNA complexes. We find that Lipofectamine, contrary to alternative formulations, is able to efficiently avoid active intracellular transport along microtubules, and the subsequent entrapment and degradation of the payload within acidic/digestive lysosomal compartments. This result is achieved by random Brownian motion of Lipofectamine-containing vesicles within the cytoplasm. We demonstrate here that Brownian diffusion is an efficient route for Lipofectamine/DNA complexes to avoid metabolic degradation, thus leading to optimal transfection. By contrast, active transport along microtubules results in DNA degradation and subsequent poor transfection. Intracellular trafficking, endosomal escape and lysosomal degradation appear therefore as highly interdependent phenomena, in such a way that they should be viewed as a single barrier on the route for efficient transfection. As a matter of fact, they should be evaluated in their entirety for the development of optimized non-viral gene delivery vectors.

Published
2016

8. Factors Determining the Superior Performance of Lipid/DNA/Protammine Nanoparticles over Lipoplexes

Author

Caracciolo, Giulio, Pozzi, Daniela, Capriotti, Anna Laura, Marianecci, Carlotta, Carafa, Maria, Marchini, Cristina, Montani, Maura, Amici, Augusto, Amenitsch, Heinz, Digman, Michelle A, Gratton, Enrico, Sanchez, Susana S, and Laganà, Aldo

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Genetics, Bioengineering, Nanotechnology, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Animals, Cell Line, Cell Line, Tumor, Cell Nucleus, Cricetinae, DNA, Fatty Acids, Monounsaturated, Gene Transfer Techniques, Humans, Nanoparticles, Particle Size, Plasmids, Protamines, Quaternary Ammonium Compounds, Surface Properties, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, Pharmacology and pharmaceutical sciences, Medicinal and biomolecular chemistry, Organic chemistry
Abstract

The utility of using a protammine/DNA complex coated with a lipid envelope made of cationic 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) for transfecting CHO (Chinese hamster ovary cells), HEK293 (human embryonic kidney cells), NIH 3T3 (mouse embryonal cells), and A17 (murine cancer cells) cells was examined. The widely used DOTAP/DNA lipoplex was employed as a reference. In all the tested cell lines lipid/protamine/DNA (LPD) nanoparticles were more efficient in transfecting cells than lipoplexes even though the lipid composition of the lipid envelope was the same in both devices. Physical-chemical properties were found to control the ability of nanocarriers to release DNA upon interaction with cellular membranes. LPD complexes easily release their DNA payload, while lipoplexes remain largely intact and accumulate at the cell nucleus. Collectively, these data explain why LPD nanoparticles often exhibit superior performances compared to lipoplexes in trasfecting cells and represent a promising class of nanocarriers for gene delivery.

Published
2011

9. Video 1 from Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, primary, Curcio, Claudia, primary, Occhipinti, Sergio, primary, Massaccesi, Luca, primary, Giovarelli, Mirella, primary, Galeazzi, Roberta, primary, Iezzi, Manuela, primary, Tilio, Martina, primary, Gambini, Valentina, primary, Wang, Junbiao, primary, Marchini, Cristina, primary, and Amici, Augusto, primary

Published
2023
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10. Supplementary S1 from Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, primary, Curcio, Claudia, primary, Occhipinti, Sergio, primary, Massaccesi, Luca, primary, Giovarelli, Mirella, primary, Galeazzi, Roberta, primary, Iezzi, Manuela, primary, Tilio, Martina, primary, Gambini, Valentina, primary, Wang, Junbiao, primary, Marchini, Cristina, primary, and Amici, Augusto, primary

Published
2023
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11. Supplementary Tables from Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, primary, Curcio, Claudia, primary, Occhipinti, Sergio, primary, Massaccesi, Luca, primary, Giovarelli, Mirella, primary, Galeazzi, Roberta, primary, Iezzi, Manuela, primary, Tilio, Martina, primary, Gambini, Valentina, primary, Wang, Junbiao, primary, Marchini, Cristina, primary, and Amici, Augusto, primary

Published
2023
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12. Data from Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, primary, Curcio, Claudia, primary, Occhipinti, Sergio, primary, Massaccesi, Luca, primary, Giovarelli, Mirella, primary, Galeazzi, Roberta, primary, Iezzi, Manuela, primary, Tilio, Martina, primary, Gambini, Valentina, primary, Wang, Junbiao, primary, Marchini, Cristina, primary, and Amici, Augusto, primary

Published
2023
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15. Data from Stathmin Is Required for Normal Mouse Mammary Gland Development and Δ16HER2-Driven Tumorigenesis

Author

Segatto, Ilenia, primary, Zompit, Mara De Marco, primary, Citron, Francesca, primary, D'Andrea, Sara, primary, Vinciguerra, Gian Luca Rampioni, primary, Perin, Tiziana, primary, Berton, Stefania, primary, Mungo, Giorgia, primary, Schiappacassi, Monica, primary, Marchini, Cristina, primary, Amici, Augusto, primary, Vecchione, Andrea, primary, Baldassarre, Gustavo, primary, and Belletti, Barbara, primary

Published
2023
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16. Video S1 from Stathmin Is Required for Normal Mouse Mammary Gland Development and Δ16HER2-Driven Tumorigenesis

Author

Segatto, Ilenia, primary, Zompit, Mara De Marco, primary, Citron, Francesca, primary, D'Andrea, Sara, primary, Vinciguerra, Gian Luca Rampioni, primary, Perin, Tiziana, primary, Berton, Stefania, primary, Mungo, Giorgia, primary, Schiappacassi, Monica, primary, Marchini, Cristina, primary, Amici, Augusto, primary, Vecchione, Andrea, primary, Baldassarre, Gustavo, primary, and Belletti, Barbara, primary

Published
2023
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17. Supplementary Materials and Methods, Figure Legends, Figures 1 - 6, Tables 1 - 2 from Chimeric Rat/Human HER2 Efficiently Circumvents HER2 Tolerance in Cancer Patients

Author

Occhipinti, Sergio, primary, Sponton, Laura, primary, Rolla, Simona, primary, Caorsi, Cristiana, primary, Novarino, Anna, primary, Donadio, Michela, primary, Bustreo, Sara, primary, Satolli, Maria Antonietta, primary, Pecchioni, Carla, primary, Marchini, Cristina, primary, Amici, Augusto, primary, Cavallo, Federica, primary, Cappello, Paola, primary, Pierobon, Daniele, primary, Novelli, Francesco, primary, and Giovarelli, Mirella, primary

Published
2023
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18. Supplementary Data from Stathmin Is Required for Normal Mouse Mammary Gland Development and Δ16HER2-Driven Tumorigenesis

Author

Segatto, Ilenia, primary, Zompit, Mara De Marco, primary, Citron, Francesca, primary, D'Andrea, Sara, primary, Vinciguerra, Gian Luca Rampioni, primary, Perin, Tiziana, primary, Berton, Stefania, primary, Mungo, Giorgia, primary, Schiappacassi, Monica, primary, Marchini, Cristina, primary, Amici, Augusto, primary, Vecchione, Andrea, primary, Baldassarre, Gustavo, primary, and Belletti, Barbara, primary

Published
2023
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19. Data from Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer

Author

Citron, Francesca, primary, Segatto, Ilenia, primary, Vinciguerra, Gian Luca Rampioni, primary, Musco, Lorena, primary, Russo, Francesca, primary, Mungo, Giorgia, primary, D'Andrea, Sara, primary, Mattevi, Maria Chiara, primary, Perin, Tiziana, primary, Schiappacassi, Monica, primary, Massarut, Samuele, primary, Marchini, Cristina, primary, Amici, Augusto, primary, Vecchione, Andrea, primary, Baldassarre, Gustavo, primary, and Belletti, Barbara, primary

Published
2023
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20. Supplementary Tables from Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer

Author

Citron, Francesca, primary, Segatto, Ilenia, primary, Vinciguerra, Gian Luca Rampioni, primary, Musco, Lorena, primary, Russo, Francesca, primary, Mungo, Giorgia, primary, D'Andrea, Sara, primary, Mattevi, Maria Chiara, primary, Perin, Tiziana, primary, Schiappacassi, Monica, primary, Massarut, Samuele, primary, Marchini, Cristina, primary, Amici, Augusto, primary, Vecchione, Andrea, primary, Baldassarre, Gustavo, primary, and Belletti, Barbara, primary

Published
2023
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21. Supplementary Figures 1-6, Supplementary Materials and Methods from Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer

Author

Citron, Francesca, primary, Segatto, Ilenia, primary, Vinciguerra, Gian Luca Rampioni, primary, Musco, Lorena, primary, Russo, Francesca, primary, Mungo, Giorgia, primary, D'Andrea, Sara, primary, Mattevi, Maria Chiara, primary, Perin, Tiziana, primary, Schiappacassi, Monica, primary, Massarut, Samuele, primary, Marchini, Cristina, primary, Amici, Augusto, primary, Vecchione, Andrea, primary, Baldassarre, Gustavo, primary, and Belletti, Barbara, primary

Published
2023
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22. Supplementary Methods from A Better Immune Reaction to Erbb-2 Tumors Is Elicited in Mice by DNA Vaccines Encoding Rat/Human Chimeric Proteins

Author

Quaglino, Elena, primary, Mastini, Cristina, primary, Amici, Augusto, primary, Marchini, Cristina, primary, Iezzi, Manuela, primary, Lanzardo, Stefania, primary, De Giovanni, Carla, primary, Montani, Maura, primary, Lollini, Pier-Luigi, primary, Masucci, Giuseppe, primary, Forni, Guido, primary, and Cavallo, Federica, primary

Published
2023
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23. Supplementary Figure 7 from A Better Immune Reaction to Erbb-2 Tumors Is Elicited in Mice by DNA Vaccines Encoding Rat/Human Chimeric Proteins

Author

Quaglino, Elena, primary, Mastini, Cristina, primary, Amici, Augusto, primary, Marchini, Cristina, primary, Iezzi, Manuela, primary, Lanzardo, Stefania, primary, De Giovanni, Carla, primary, Montani, Maura, primary, Lollini, Pier-Luigi, primary, Masucci, Giuseppe, primary, Forni, Guido, primary, and Cavallo, Federica, primary

Published
2023
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24. Supplementary Figure 6 from A Better Immune Reaction to Erbb-2 Tumors Is Elicited in Mice by DNA Vaccines Encoding Rat/Human Chimeric Proteins

Author

Quaglino, Elena, primary, Mastini, Cristina, primary, Amici, Augusto, primary, Marchini, Cristina, primary, Iezzi, Manuela, primary, Lanzardo, Stefania, primary, De Giovanni, Carla, primary, Montani, Maura, primary, Lollini, Pier-Luigi, primary, Masucci, Giuseppe, primary, Forni, Guido, primary, and Cavallo, Federica, primary

Published
2023
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25. Data from A Better Immune Reaction to Erbb-2 Tumors Is Elicited in Mice by DNA Vaccines Encoding Rat/Human Chimeric Proteins

Author

Quaglino, Elena, primary, Mastini, Cristina, primary, Amici, Augusto, primary, Marchini, Cristina, primary, Iezzi, Manuela, primary, Lanzardo, Stefania, primary, De Giovanni, Carla, primary, Montani, Maura, primary, Lollini, Pier-Luigi, primary, Masucci, Giuseppe, primary, Forni, Guido, primary, and Cavallo, Federica, primary

Published
2023
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26. Supplementary Figure 8 from A Better Immune Reaction to Erbb-2 Tumors Is Elicited in Mice by DNA Vaccines Encoding Rat/Human Chimeric Proteins

Author

Quaglino, Elena, primary, Mastini, Cristina, primary, Amici, Augusto, primary, Marchini, Cristina, primary, Iezzi, Manuela, primary, Lanzardo, Stefania, primary, De Giovanni, Carla, primary, Montani, Maura, primary, Lollini, Pier-Luigi, primary, Masucci, Giuseppe, primary, Forni, Guido, primary, and Cavallo, Federica, primary

Published
2023
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27. Supplementary Figure 1 from A Better Immune Reaction to Erbb-2 Tumors Is Elicited in Mice by DNA Vaccines Encoding Rat/Human Chimeric Proteins

Author

Quaglino, Elena, primary, Mastini, Cristina, primary, Amici, Augusto, primary, Marchini, Cristina, primary, Iezzi, Manuela, primary, Lanzardo, Stefania, primary, De Giovanni, Carla, primary, Montani, Maura, primary, Lollini, Pier-Luigi, primary, Masucci, Giuseppe, primary, Forni, Guido, primary, and Cavallo, Federica, primary

Published
2023
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28. Supplementary Figure 5 from A Better Immune Reaction to Erbb-2 Tumors Is Elicited in Mice by DNA Vaccines Encoding Rat/Human Chimeric Proteins

Author

Quaglino, Elena, primary, Mastini, Cristina, primary, Amici, Augusto, primary, Marchini, Cristina, primary, Iezzi, Manuela, primary, Lanzardo, Stefania, primary, De Giovanni, Carla, primary, Montani, Maura, primary, Lollini, Pier-Luigi, primary, Masucci, Giuseppe, primary, Forni, Guido, primary, and Cavallo, Federica, primary

Published
2023
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29. Supplementary Figure Legends 1-4, Tables Legends 1-8 from A Better Immune Reaction to Erbb-2 Tumors Is Elicited in Mice by DNA Vaccines Encoding Rat/Human Chimeric Proteins

Author

Quaglino, Elena, primary, Mastini, Cristina, primary, Amici, Augusto, primary, Marchini, Cristina, primary, Iezzi, Manuela, primary, Lanzardo, Stefania, primary, De Giovanni, Carla, primary, Montani, Maura, primary, Lollini, Pier-Luigi, primary, Masucci, Giuseppe, primary, Forni, Guido, primary, and Cavallo, Federica, primary

Published
2023
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30. Supplementary Figure 2 from A Better Immune Reaction to Erbb-2 Tumors Is Elicited in Mice by DNA Vaccines Encoding Rat/Human Chimeric Proteins

Author

Quaglino, Elena, primary, Mastini, Cristina, primary, Amici, Augusto, primary, Marchini, Cristina, primary, Iezzi, Manuela, primary, Lanzardo, Stefania, primary, De Giovanni, Carla, primary, Montani, Maura, primary, Lollini, Pier-Luigi, primary, Masucci, Giuseppe, primary, Forni, Guido, primary, and Cavallo, Federica, primary

Published
2023
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31. Supplementary Figure 3 from A Better Immune Reaction to Erbb-2 Tumors Is Elicited in Mice by DNA Vaccines Encoding Rat/Human Chimeric Proteins

Author

Quaglino, Elena, primary, Mastini, Cristina, primary, Amici, Augusto, primary, Marchini, Cristina, primary, Iezzi, Manuela, primary, Lanzardo, Stefania, primary, De Giovanni, Carla, primary, Montani, Maura, primary, Lollini, Pier-Luigi, primary, Masucci, Giuseppe, primary, Forni, Guido, primary, and Cavallo, Federica, primary

Published
2023
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32. Supplementary Figure 4 from A Better Immune Reaction to Erbb-2 Tumors Is Elicited in Mice by DNA Vaccines Encoding Rat/Human Chimeric Proteins

Author

Quaglino, Elena, primary, Mastini, Cristina, primary, Amici, Augusto, primary, Marchini, Cristina, primary, Iezzi, Manuela, primary, Lanzardo, Stefania, primary, De Giovanni, Carla, primary, Montani, Maura, primary, Lollini, Pier-Luigi, primary, Masucci, Giuseppe, primary, Forni, Guido, primary, and Cavallo, Federica, primary

Published
2023
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33. Mechanistic Insights into the Superior DNA Delivery Efficiency of Multicomponent Lipid Nanoparticles: An In Vitro and In Vivo Study

Author

Quagliarini, Erica, primary, Wang, Junbiao, additional, Renzi, Serena, additional, Cui, Lishan, additional, Digiacomo, Luca, additional, Ferri, Gianmarco, additional, Pesce, Luca, additional, De Lorenzi, Valentina, additional, Matteoli, Giulia, additional, Amenitsch, Heinz, additional, Masuelli, Laura, additional, Bei, Roberto, additional, Pozzi, Daniela, additional, Amici, Augusto, additional, Cardarelli, Francesco, additional, Marchini, Cristina, additional, and Caracciolo, Giulio, additional

Published
2022
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34. HER2-Displaying M13 Bacteriophages induce Therapeutic Immunity against Breast Cancer

Author

Wang, Junbiao, primary, Lamolinara, Alessia, additional, Conti, Laura, additional, Giangrossi, Mara, additional, Cui, Lishan, additional, Morelli, Maria Beatrice, additional, Amantini, Consuelo, additional, Falconi, Maurizio, additional, Bartolacci, Caterina, additional, Andreani, Cristina, additional, Orlando, Fiorenza, additional, Provinciali, Mauro, additional, Del Pizzo, Francesco Domenico, additional, Russo, Francesca, additional, Belletti, Barbara, additional, Riccardo, Federica, additional, Bolli, Elisabetta, additional, Quaglino, Elena, additional, Cavallo, Federica, additional, Amici, Augusto, additional, Iezzi, Manuela, additional, and Marchini, Cristina, additional

Published
2022
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35. Efficient Delivery of DNA Using Lipid Nanoparticles

Author

Cui, Lishan, primary, Renzi, Serena, additional, Quagliarini, Erica, additional, Digiacomo, Luca, additional, Amenitsch, Heinz, additional, Masuelli, Laura, additional, Bei, Roberto, additional, Ferri, Gianmarco, additional, Cardarelli, Francesco, additional, Wang, Junbiao, additional, Amici, Augusto, additional, Pozzi, Daniela, additional, Marchini, Cristina, additional, and Caracciolo, Giulio, additional

Published
2022
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41. The water soluble ruthenium(II) organometallic compound [Ru(p-cymene)(bis(3,5 dimethylpyrazol-1-yl)methane)Cl]Cl suppresses triple negative breast cancer growth by inhibiting tumor infiltration of regulatory T cells

Author

Montani, Maura, Pazmay, Gretta V. Badillo, Hysi, Albana, Lupidi, Giulio, Pettinari, Riccardo, Gambini, Valentina, Tilio, Martina, Marchetti, Fabio, Pettinari, Claudio, Ferraro, Stefano, Iezzi, Manuela, Marchini, Cristina, and Amici, Augusto

Published
2016
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42. Microfluidic Formulation of DNA-Loaded Multicomponent Lipid Nanoparticles for Gene Delivery

Author

Quagliarini, Erica, primary, Renzi, Serena, additional, Digiacomo, Luca, additional, Giulimondi, Francesca, additional, Sartori, Barbara, additional, Amenitsch, Heinz, additional, Tassinari, Valentina, additional, Masuelli, Laura, additional, Bei, Roberto, additional, Cui, Lishan, additional, Wang, Junbiao, additional, Amici, Augusto, additional, Marchini, Cristina, additional, Pozzi, Daniela, additional, and Caracciolo, Giulio, additional

Published
2021
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46. Evaluation of anticancer role of a novel ruthenium(II)-based compound compared with NAMI-A and cisplatin in impairing mitochondrial functionality and promoting oxidative stress in triple negative breast cancer models

Author

Silvestri, Sonia, primary, Cirilli, Ilenia, additional, Marcheggiani, Fabio, additional, Dludla, Phiwayinkosi, additional, Lupidi, Giulio, additional, Pettinari, Riccardo, additional, Marchetti, Fabio, additional, Di Nicola, Corrado, additional, Falcioni, Giancarlo, additional, Marchini, Cristina, additional, Orlando, Patrick, additional, Tiano, Luca, additional, and Amici, Augusto, additional

Published
2021
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48. Acetylshikonin isolated from Lithospermum erythrorhizon roots inhibits dihydrofolate reductase and hampers autochthonous mammary carcinogenesis in Δ16HER2 transgenic mice

Author

Wang, Junbiao, primary, Iannarelli, Romilde, additional, Pucciarelli, Stefania, additional, Laudadio, Emiliano, additional, Galeazzi, Roberta, additional, Giangrossi, Mara, additional, Falconi, Maurizio, additional, Cui, Lishan, additional, Navia, Aleix Marti, additional, Buccioni, Michela, additional, Marucci, Gabriella, additional, Tomassoni, Daniele, additional, Serini, Laura, additional, Sut, Stefania, additional, Maggi, Filippo, additional, Dall’Acqua, Stefano, additional, Marchini, Cristina, additional, and Amici, Augusto, additional

Published
2020
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49. Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer

Author

Citron, Francesca, primary, Segatto, Ilenia, additional, Vinciguerra, Gian Luca Rampioni, additional, Musco, Lorena, additional, Russo, Francesca, additional, Mungo, Giorgia, additional, D'Andrea, Sara, additional, Mattevi, Maria Chiara, additional, Perin, Tiziana, additional, Schiappacassi, Monica, additional, Massarut, Samuele, additional, Marchini, Cristina, additional, Amici, Augusto, additional, Vecchione, Andrea, additional, Baldassarre, Gustavo, additional, and Belletti, Barbara, additional

Published
2020
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