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211 results on '"Marchetti, Marcello"'

2. Stereotactic Radiosurgery for Intracranial Noncavernous Sinus Benign Meningioma: International Stereotactic Radiosurgery Society Systematic Review, Meta-Analysis and Practice Guideline

Author

Marchetti, Marcello, Sahgal, Arjun, De Salles, Antonio AF, Levivier, Marc, Ma, Lijun, Paddick, Ian, Pollock, Bruce E, Regis, Jean, Sheehan, Jason, Suh, John H, Yomo, Shoji, and Fariselli, Laura

Subjects
Brain Disorders, Cancer, Rare Diseases, Neurosciences, Brain Cancer, Female, Humans, Male, Meningeal Neoplasms, Meningioma, Radiosurgery, Treatment Outcome, Multisession-radiosurgery, Fractionated radiosurgery, Hypofractionated stereotactic radiotherapy, Guidelines, Systematic review, Clinical Sciences, Neurology & Neurosurgery
Abstract

BackgroundStereotactic radiosurgery (SRS) for benign intracranial meningiomas is an established treatment.ObjectiveTo summarize the literature and provide evidence-based practice guidelines on behalf of the International Stereotactic Radiosurgery Society (ISRS).MethodsArticles in English specific to SRS for benign intracranial meningioma, published from January 1964 to April 2018, were systematically reviewed. Three electronic databases, PubMed, EMBASE, and the Cochrane Central Register, were searched.ResultsOut of the 2844 studies identified, 305 had a full text evaluation and 27 studies met the criteria to be included in this analysis. All but one were retrospective studies. The 10-yr local control (LC) rate ranged from 71% to 100%. The 10-yr progression-free-survival rate ranged from 55% to 97%. The prescription dose ranged typically between 12 and 15 Gy, delivered in a single fraction. Toxicity rate was generally low.ConclusionThe current literature supporting SRS for benign intracranial meningioma lacks level I and II evidence. However, when summarizing the large number of level III studies, it is clear that SRS can be recommended as an effective evidence-based treatment option (recommendation level II) for grade 1 meningioma.

Published
2020

5. Study on the Fate of the Carbopol ® Polymer in the Use of Hand Sanitizer Gels: An Experimental Model to Monitor Its Physical State from Product Manufacturing up to the Final Hand Rinse.

Author

Marchetti, Marcello, Perini, Alessandro, Zanella, Michela, Benetti, Federico, and Donelli, Daniela

Subjects
*PRODUCT life cycle, *HAND sanitizers, *POLYACRYLIC acid, *MICROPLASTICS, *COPOLYMERS, *PLASTIC marine debris
Abstract

Carbopol® is a typical jelly agent belonging to the family of cross-linked polyacrylic acid copolymers. It is largely used in antibacterial gels due to its self-wetting properties. In its pristine physical form, Carbopol® falls under the definition of microplastics, though significant changes could occur once added to hydroalcoholic solvents of the liquid formulations. To date, no life-cycle data regarding the physical state are available for this substance or for other similar polymers of the same chemical class. The aim of the present study was the investigation of the fate of Carbopol®-derived microplastics used in the formulation of typical hand sanitizer gels available in the Italian market, such as Amuchina® X-Germ, along the product life cycle. An experimental model was designed to detect the presence of Carbopol® microparticles from product manufacturing to the final use. FTIR and µ-FTIR were used to detect and characterize solid particles after the optimization of the sample preparation of different experimental matrices. While Carbopol® as such can be classified as a microplastic, in the commercial product, Carbopol® particles were not detected. Ten volunteers used the product according to the instructions reported on the label, and finally they rinsed their hands. Carbopol®-based particles were not detected in the water rinse, indicating that, after usage, the original form of the Carbopol microparticles was not retrieved. The study proposes, for the first time, a simple and comprehensive experimental approach to identify and characterize microplastics in finished products and along the life cycle by simulating their real-life usage. This approach could be also useful to evaluate the release of chemical components into the environment through the use of dermal products. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Surgical and radiosurgical treatment of hypothalamic hamartoma: The Italian experience between 2011 and 2021.

Author

Rizzi, Michele, Consales, Alessandro, Tramacere, Irene, De Benedictis, Alessandro, Bua, Antonella, Specchio, Nicola, De Palma, Luca, Cognolato, Erica, Nobili, Lino, Tortora, Domenico, Barba, Carmen, Pommella, Marianna, Giordano, Flavio, Pastori, Chiara, Marchetti, Marcello, Garbelli, Rita, Zucchelli, Mino, Martinoni, Matteo, Ferri, Lorenzo, and Martucci, Matia

Subjects
EPILEPSY surgery, STEREOTACTIC radiosurgery, PEOPLE with epilepsy, UNIVARIATE analysis, SEIZURES (Medicine)
Abstract

Objective: To investigate the Italian experience on the surgical and radiosurgical treatment of drug‐resistant epilepsy due to hypothalamic hamartoma (HH) in the period 2011–2021 in six Italian epilepsy surgery centers, and to compare safety and efficacy profiles of the different techniques. Methods: We collected pseudo‐anonymized patient's data with at least 12 months of follow‐up. Surgical outcome was defined according to Engel classification of seizure outcome. Univariate analysis was performed to assess the risk of post‐operative seizures, categorized in dichotomous variable as favorable and unfavorable; explanatory variables were considered. Mann–Whitney or Chi‐squared test were used to assess the presence of an association between variables (p < 0.05). Results: Full presurgical and postoperative data about 42 patients from 6 epilepsy surgery centers were gathered. Engel class I was reached in the 65.8% and 66.6% of patients with gelastic and non‐gelastic seizures, respectively. Other than daily non‐gelastic seizures were associated with seizure freedom (p = 0.01), and the radiological type presented a trend toward significance (p = 0.12). Significance: Endoscopic disconnection and laser interstitial thermal therapy are effective in the treatment of HH‐related epilepsy, with a tolerable safety profile. Both gelastic and non‐gelastic seizures can be treated, also in patients with a long history of seizures. Plain Language Summary: This study collected data about 42 patients with HH‐related epilepsies. Endoscopic disconnection and laser therapy are both effective and safe in the treatment of hypothalamic hamartoma‐related epilepsies. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Spinal Meningioma Radiosurgery

Author

Marchetti, Marcello, Pinzi, Valentina, De Martin, Elena, Morlino, Sara, Fariselli, Laura, Longhi, Michele, editor, Motti, Enrico D. F., editor, Nicolato, Antonio, editor, and Picozzi, Piero, editor

Published
2021
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8. Movement Disorders

Author

Marchetti, Marcello, Conti, Alfredo, Franzini, Angelo, Fariselli, Laura, Conti, Alfredo, editor, Romanelli, Pantaleo, editor, Pantelis, Evangelos, editor, Soltys, Scott G., editor, Cho, Young Hyun, editor, and Lim, Michael, editor

Published
2020
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9. Perioptic Meningiomas

Author

Fariselli, Laura, Pinzi, Valentina, Morlino, Sara, Marchetti, Marcello, Conti, Alfredo, editor, Romanelli, Pantaleo, editor, Pantelis, Evangelos, editor, Soltys, Scott G., editor, Cho, Young Hyun, editor, and Lim, Michael, editor

Published
2020
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11. Fiber-Optics Quench Detection Schemes in HTS Cables for Fusion Magnets

Author

Colombo, Gabriele, Adibi, Sayyed Ashkan, Breschi, Marco, Caponero, Michele A., Castaldo, Antonio, Celentano, Giuseppe, Corte, Antonio della, Marchetti, Marcello, Masi, Andrea, Mazzotta, Cristina, Muzzi, Luigi, Polimadei, Andrea, Savoldi, Laura, Trotta, Antonio, Zanon, Fabio, and De Marzi, Gianluca

Abstract

In this article, we report the results from two test campaigns conducted to evaluate the feasibility of implementing a commercially available optical fiber-based distributed sensing technology for Quench Detection (QD) purposes. We successfully characterized the temperature response and sensitivity achievable by this technique when using a bare single mode fiber within a cryogen free cooling system operating in the temperature range from 4 K to 300 K. A fiber was also incorporated into a sample featuring an High-Temperature Superconductor (HTS) stack mounted onto an extruded Aluminum slotted-core cable. Quench-like events were triggered by locally lowering the critical current using the magnetic field produced by a set of permanent magnets placed near the center of the stack. The experiments were carried out at 77 K by cooling the sample through the central channel of the Aluminum core with a forced flow of liquid nitrogen. The test results indicate the viability of this technology as a suitable alternative for QD in long-length HTS cables and motivate further work to develop distributed sensing systems able to work in the conditions foreseen for HTS fusion coils.

Published
2024
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12. Schwannomas and Neurofibromas

Author

Marchetti, Marcello, De Martin, Elena, Fariselli, Laura, Chang, Eric L., editor, Brown, Paul D., editor, Lo, Simon S., editor, Sahgal, Arjun, editor, and Suh, John H., editor

Published
2018
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16. Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

Author

Rottoli, Matteo, Gori, Alice, Pellino, Gianluca, Flacco, Maria Elena, Martellucci, Cecilia, Spinelli, Antonino, Poggioli, Gilberto, Romano, Angela, Belvedere, Angela, Lanci Lanci, Antonio, Parlanti, Daniele, Vago, Gabriele, Pezzuto, Paola, Canavese, Anna, Dajti, Gerti, Cardelli, Stefano, Catalioto, Caterina, Russo, Iris S, Violante, Tommaso, Morezzi, Daniele, Maurino, Ludovica, Filippone, Eleonora, Cuicchi, Dajana, Bernante, Paolo, Jovine, Elio, Lombardi, Raffaele, Masetti, Michele, Cipressi, Chiara, Offi, Maria F, Larotonda, Cristina, Puglisi, Silvana B, Barbosa, Augusto, Vaiana, Roberto, Bianchi, Paolo M, Tonti, Carlo, Codignola, Claudio, Zorcolo, Luigi, Restivo, Angelo, Deidda, Simona, Marchetti, Marcello E, Ippolito, Luca, Spolverato, Gaya, Pucciarelli, Salvatore, Marchegiani, Francesco, Ghio, Giacomo, Zagolin, Gaya, Glavas, Dajana, Tomassi, Monica, Rosati, Riccardo, Elmore, Ugo, Gozzini, Lorenzo, Calef, Riccardo, Puccetti, Francesco, Cossu, Andrea, Vignali, Andrea, Morino, Mario, Allaix, Marco E, Cannata, Gaspare, Lombardi, Erica, Ammirati, Carlo A, Piceni, Chiara, Buccianti, Piero, Balestri, Riccardo, Puccini, Marco, Pezzati, Daniele, d'Ischia, Roberto, Asta, Vito F, Sargenti, Benedetta, Taddei, Giacomo, Bonari, Federica, Boni, Giulia, Ferrero, Alessandro, Mineccia, Michela, Gonella, Federica, Palisi, Marco, Danese, Francesco, Cherubini, Valeria, Perotti, Serena, Carvello, Michele, Carbone, Fabio, Luberto, Antonio, Calafiore, Eleonora, De Lucia, Francesca, Sacchi, Matteo, Sasia, Diego, Giuffrida, Maria C, Ballauri, Edoardo, Cardile, Mathieu, Armentano, Serena, Beltrami, Elsa, Preve, Gabriele, Vercellone, Barbara, Mozzon, Marta, Folliero, Cristina, Lirusso, Chiara, Vecchiato, Massimo, Ziccarelli, Antonio, Gattesco, Davide, Moretti, Luisa, Crestale, Sara, Banchini, Filippo, Capelli, Patrizio, Romboli, Andrea, Palmieri, Gerardo, Conti, Luigi, Rizzi, Nicholas, Bonfili, Deborah, de Manzini, Nicolò, Germani, Paola, Osenda, Edoardo, Cortinovis, Sara, Giunta, Carlotta, Fracon, Stefano, Abdallah, Hussein, Bogoni, Selene, Portolani, Nazario, Nascimbeni, Riccardo, Molfino, Sarah, Tiberio, Guido A M, Garosio, Ilenia, Lamperti, Giulia, Rigosa, Diego, Ercolani, Giorgio, Solaini, Leonardo, Cavaliere, Davide, Avanzolini, Andrea, D'Acapito, Fabrizio, Chiarella, Leonardo L, Di Pietrantonio, Daniela, Annunziata, Domenico, Piccolo, Roberta, Sorrentino, Mario, Pansini, Mauro, Cojutti, Alessandro, Graziano, Michele, Callegari, Francesco, Balzarotti, Laura, Dameno, Vitale R, Cattaneo, Antonio, Santolamazza, Giuliano, Altieri, Caterina, Magarini, Riccardo, Pietrabissa, Andrea, Dominioni, Tommaso, Pugliese, Luigi, Peri, Andrea, Botti, Marta, Salvetti, Francesco, Cassinotti, Elisa, Baldari, Ludovica, Boni, Luigi, Messina, Valentina, D'Abrosca, Vera, Cianci, Pasquale, Tumolo, Rocco, Gattulli, Domenico, Restini, Enrico, Minafra, Marina, Sederino, Maria G, Bottalico, Bernardino, Pilati, Pierluigi, Franzato, Boris, Mattara, Genny, De Simoni, Ottavia, Barina, Andrea, Tonello, Marco, Muratore, Andrea, Calabrò, Marcello, Federico Pipitone, Nicoletta S, Cuzzola, Bruno, Herranz van Nood, Elena, Passuello, Nicola, Frasson, Alvise, Mammano, Enzo, Faccio, Luca, Vittadello, Fabrizio, Bressan, Alice, Sarzo, Giacomo, Tamini, Nicolò, Oldani, Massimo, Cigagna, Luca, Carissimi, Francesca, De Carlo, Giulia, Baccalini, Edoardo, Nespoli, Luca, Giordano, Alessio, Cantafio, Stefano, Grifoni, Lucrezia, Matani, Davide, Livi, Serena, Delogu, Daniele, Scognamillo, Fabrizio, Marrosu, Antonio, Guerrini, Luca, Ugolini, Giampaolo, Ghignone, Federico, Frascaroli, Giacomo, Albertini, Nicola, Zattoni, Davide, Taffurelli, Giovanni, Montroni, Isacco, Colombo, Francesco, Danelli, Piergiorgio, Bondurri, Andrea, Maffioli, Anna, Bonomi, Alessandro, Pezzoli, Isabella, Cammarata, Francesco, Goletti, Orlando, Molteni, Mattia, Assisi, Alberto, Quartierini, Giorgio, Da Lio, Corrado, Verdi, Daunia, Mondi, Isabella, Peluso, Claudia, Macchi, Lorenzo, Tanzanu, Marta, Zanzi, Federico, Pellegrini, Sara, Andreuccetti, Jacopo, D'Alessio, Rossella, Pignata, Giusto, De Capua, Michele, Canfora, Ilaria, Ottaviani, Luca, Lepiane, Pasquale, Balla, Andrea, De Carlo, Antonio, Saraceno, Federica, Scaramuzzo, Rosa, Guida, Anna, Aguzzi, Daniele, Bellora, Paolo, Gentilli, Sergio, Monni, Manuela, Nikaj, Herald, Cillara, Nicola, Cannavera, Alessandro, Deserra, Antonello, Margiani, Carla, Cabula, Roberta, Dettori, Manuela, Gramignano, Giulia, Lezoche, Giovanni, Ortenzi, Monica, Orlandoni, Elena S, Curzi, Federica, Vitali, Francesca, Capomagi, Perla, Palmieri, Miriam, Giuffrida, Mario, Del Rio, Paolo, Bonati, Elena, Loderer, Tommaso, Cozzani, Federico, Rossini, Matteo, Agnesi, Stefano, Capolupo, Gabriella T, Caricato, Marco, Carannante, Filippo, Mascianà, Gianluca, Marrelli, Martina, Miacci, Valentina, Lauricella, Sara, Tonini, Valeria, Cervellera, Maurizio, Pisconti, Salvatore, Lozito, Concetta, Shahu, Juliana, Mongelli, Claudia, Morelli, Giulia, Sartarelli, Lodovico, Sica, Giuseppe S, Siragusa, Leandro, Bagaglini, Giulia, Sensi, Bruno, Guida, Andrea M, Franceschilli, Marzia, Vinci, Danilo, Taddei, Antonio, Risaliti, Matteo, Bartolini, Ilenia, Ringressi, Maria N, Tirloni, Luca, Laface, Letizia, Abate, Emmanuele, Casati, Massimiliano, Gobbi, Pietro, Opocher, Enrico, Mariani, Nicolò M, Pisani Ceretti, Andrea, Giovenzana, Marco, Giuliani, Beatrice, Sironi, Martina, Grossi, Ugo, Zanus, Giacomo, Aniello Santoro, Giulio, Brizzolari, Marco, De Leo, Eugenio, Novello, Simone, Aquilino, Krizia, Milardi, Francesco, Olmi, Stefano, Uccelli, Matteo, Bonaldi, Marta, Cesana, Giovanni C, Bindi, Marco, Galleano, Raffaele, Langone, Antonio, Botto, Massimiliano, Franceschi, Angelo, Gambino, Elena, Ronconi, Maurizio, Casiraghi, Silvia, Casole, Giovanni, Ciulla, Salvatore L, Terrosu, Giovanni, Calandra, Sergio, Scarpa, Edoardo, Cherchi, Vittorio, Calini, Giacomo, Martinuzzo, Lisa, Clocchiatti, Lucrezia, Muschitiello, Davide, Romanzi, Andrea, Vignati, Barbara, Vannelli, Alberto, Scolaro, Roberta, Milanesi, Maria, Rossi, Fabrizio, Canonico, Giuseppe, Anastasi, Alessandro, Nelli, Tommaso, Barlettai, Marco, Fratarcangeli, Riccardo, Di Martino, Carmela, Damigella, Andrea, Adinolfi, Elvira, Birindelli, Arianna, Taglietti, Lucio, Dester, Sara E, Fleres, Francesco, Cucinotta, Eugenio, Viscosi, Francesca, Biondo Santino, Antonio, Badessi, Giorgio, Catarsini, Nivia, Mazzeo, Carmelo, Rega, Daniela, Delrio, Paolo, Cervone, Carmela, Aversano, Alessia, De Franciscis, Silvia, Di Marzo, Massimiliano, Marra, Bruno, Pace, Ugo, Amato, Antonio, Batistotti, Paola, Mina, Elisa, Serventi, Alberto, Lapolla, Pierfrancesco, Mingoli, Andrea, Sapienza, Paolo, Brachini, Gioia, Cirillo, Bruno, Fiori, Enrico, Crocetti, Daniele, Clementi, Ilaria, Martines, Gennaro, Picciariello, Arcangelo, Tomasicchio, Giovanni, Dibra, Rigers, Trigiante, Giuseppe, Rinaldi, Marcella, Lantone, Giuliano, Porcu, Alberto, Perra, Teresa, Scanu, Antonio M, Feo, Claudio F, Fancellu, Alessandro, Cossu, Maria L, Ginesu, Giorgio C, Patriti, Alberto, Coletta, Diego, Petrelli, Filippo, Greco, Paola A, Spadoni, Claudia, Cassiani, Giovanna, Bianchini, Federica, Arganini, Marco, Bianchini, Matteo, Perotti, Bruno, Palmeri, Matteo, Scabini, Stefano, Deiana, Selene, Carganico, Giacomo, Pertile, Davide, Soriero, Domenico, Fioravanti, Emanuela, Sperotto, Beatrice, Nardo, Bruno, Paglione, Daniele, Crocco, Veronica, Doni, Marco, Osso, Mariasara, Perri, Roberto, Sampietro, Gianluca M, Corbellini, Carlo, Lorusso, Leonardo, Manzo, Carlo A, Cigognini, Maria, Baldi, Caterina, Palomba, Giuseppe, Aprea, Giovanni, Capuano, Marianna, Basile, Raffaele, Tutino, Roberta, Massani, Marco, Marinelli, Laura, Canitano, Nicola, Pilia, Tiziana, Podda, Mauro, Pisanu, Adolfo, Murzi, Valentina, Incani, Silvia, Frongia, Federica, Esposito, Giuseppe, Luglio, Gaetano, Tropeano, Francesca P, Pagano, Gianluca, Spina, Eduardo, De Simone, Giuseppe, Cricrì, Michele, Catena, Fausto, Vallicelli, Carlo, Zanini, Nicola, Ronconi, Diana, Favi, Francesco, Mazzucchelli, Carlo, Convertini, Girolamo, Vincenti, Leonardo, Andriola, Valeria, Bizzoca, Cinzia, Feo, Carlo V, Fabbri, Nicolò, Fazzin, Marta, Pesce, Antonio, Gennari, Silvia, Torchiaro, Marco, Severi, Silvia, Frontali, Alice, Bracchetti, Greta, Granieri, Stefano, Cotsoglou, Christian, Carlini, Massimo, Lisi, Giorgio, Spoletini, Domenico, Mastrangeli, Maria R, Campanelli, Michela, Manigrasso, Michele, Milone, Marco, De Palma, Giovanni D, Vertaldi, Sara, Chini, Alessia, Maione, Francesco, Marello, Alessandra, Selvaggi, Francesco, Sciaudone, Guido, Selvaggi, Lucio, Menegon Tasselli, Francesco, Fuschillo, Giacomo, Oddis, Lidia, Grande, Simona, Grande, Michele, Ascanelli, Simona, Chimisso, Laura, Aisoni, Filippo, Rossin, Eleonora, Pepe, Francesco, Marchetti, Francesco, Picardi, Biagio, Rossi, Stefano, Rossi Del Monte, Simone, Picarelli, Matteo, Muttillo, Irnerio A, Ratto, Carlo, Marra, Angelo A, Parello, Angelo, Litta, Francesco, Campennì, Paola, De Simone, Veronica, Pata, Francesco, Riboni, Cristiana, Rausa, Emanuele, Celentano, Valerio, Institut Català de la Salut, [Rottoli M, Gori A, Pellino G] Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero–Universitaria di Bologna, Bologna, Italy. Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero–Universitaria di Bologna, Bologna, Italy. [Pellino G] Department of Advanced Medical and Surgical Sciences, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy. Unitat de Cirurgia de Còlon i Recte, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Flacco ME, Martellucci C] Department of Environmental and Preventive Sciences, University of Ferrara, Ferrara, Italy. [Spinelli A] Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy. Colorectal Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy, Vall d'Hebron Barcelona Hospital Campus, Rottoli, Matteo, Gori, Alice, Pellino, Gianluca, Flacco, Maria Elena, Martellucci, Cecilia, Spinelli, Antonino, Poggioli, Gilberto, Romano, Angela, Belvedere, Angela, Lanci Lanci, Antonio, Parlanti, Daniele, Vago, Gabriele, Pezzuto, Paola, Canavese, Anna, Dajti, Gerti, Cardelli, Stefano, Catalioto, Caterina, Russo, Iris S, Violante, Tommaso, Morezzi, Daniele, Maurino, Ludovica, Filippone, Eleonora, Cuicchi, Dajana, Bernante, Paolo, Jovine, Elio, Lombardi, Raffaele, Masetti, Michele, Cipressi, Chiara, Offi, Maria F, Larotonda, Cristina, Puglisi, Silvana B, Barbosa, Augusto, Vaiana, Roberto, Bianchi, Paolo M, Tonti, Carlo, Codignola, Claudio, Zorcolo, Luigi, Restivo, Angelo, Deidda, Simona, Marchetti, Marcello E, Ippolito, Luca, Spolverato, Gaya, Pucciarelli, Salvatore, Marchegiani, Francesco, Ghio, Giacomo, Zagolin, Gaya, Glavas, Dajana, Tomassi, Monica, Rosati, Riccardo, Elmore, Ugo, Gozzini, Lorenzo, Calef, Riccardo, Puccetti, Francesco, Cossu, Andrea, Vignali, Andrea, Morino, Mario, Allaix, Marco E, Cannata, Gaspare, Lombardi, Erica, Ammirati, Carlo A, Piceni, Chiara, Buccianti, Piero, Balestri, Riccardo, Puccini, Marco, Pezzati, Daniele, d'Ischia, Roberto, Asta, Vito F, Sargenti, Benedetta, Taddei, Giacomo, Bonari, Federica, Boni, Giulia, Ferrero, Alessandro, Mineccia, Michela, Gonella, Federica, Palisi, Marco, Danese, Francesco, Cherubini, Valeria, Perotti, Serena, Carvello, Michele, Carbone, Fabio, Luberto, Antonio, Calafiore, Eleonora, De Lucia, Francesca, Sacchi, Matteo, Sasia, Diego, Giuffrida, Maria C, Ballauri, Edoardo, Cardile, Mathieu, Armentano, Serena, Beltrami, Elsa, Preve, Gabriele, Vercellone, Barbara, Mozzon, Marta, Folliero, Cristina, Lirusso, Chiara, Vecchiato, Massimo, Ziccarelli, Antonio, Gattesco, Davide, Moretti, Luisa, Crestale, Sara, Banchini, Filippo, Capelli, Patrizio, Romboli, Andrea, Palmieri, Gerardo, Conti, Luigi, Rizzi, Nichola, Bonfili, Deborah, de Manzini, Nicolò, Germani, Paola, Osenda, Edoardo, Cortinovis, Sara, Giunta, Carlotta, Fracon, Stefano, Abdallah, Hussein, Bogoni, Selene, Portolani, Nazario, Nascimbeni, Riccardo, Molfino, Sarah, Tiberio, Guido A M, Garosio, Ilenia, Lamperti, Giulia, Rigosa, Diego, Ercolani, Giorgio, Solaini, Leonardo, Cavaliere, Davide, Avanzolini, Andrea, D'Acapito, Fabrizio, Chiarella, Leonardo L, Di Pietrantonio, Daniela, Annunziata, Domenico, Piccolo, Roberta, Sorrentino, Mario, Pansini, Mauro, Cojutti, Alessandro, Graziano, Michele, Callegari, Francesco, Balzarotti, Laura, Dameno, Vitale R, Cattaneo, Antonio, Santolamazza, Giuliano, Altieri, Caterina, Magarini, Riccardo, Pietrabissa, Andrea, Dominioni, Tommaso, Pugliese, Luigi, Peri, Andrea, Botti, Marta, Salvetti, Francesco, Cassinotti, Elisa, Baldari, Ludovica, Boni, Luigi, Messina, Valentina, D'Abrosca, Vera, Cianci, Pasquale, Tumolo, Rocco, Gattulli, Domenico, Restini, Enrico, Minafra, Marina, Sederino, Maria G, Bottalico, Bernardino, Pilati, Pierluigi, Franzato, Bori, Mattara, Genny, De Simoni, Ottavia, Barina, Andrea, Tonello, Marco, Muratore, Andrea, Calabrò, Marcello, Federico Pipitone, Nicoletta S, Cuzzola, Bruno, Herranz van Nood, Elena, Passuello, Nicola, Frasson, Alvise, Mammano, Enzo, Faccio, Luca, Vittadello, Fabrizio, Bressan, Alice, Sarzo, Giacomo, Tamini, Nicolò, Oldani, Massimo, Cigagna, Luca, Carissimi, Francesca, De Carlo, Giulia, Baccalini, Edoardo, Nespoli, Luca, Giordano, Alessio, Cantafio, Stefano, Grifoni, Lucrezia, Matani, Davide, Livi, Serena, Delogu, Daniele, Scognamillo, Fabrizio, Marrosu, Antonio, Guerrini, Luca, Ugolini, Giampaolo, Ghignone, Federico, Frascaroli, Giacomo, Albertini, Nicola, Zattoni, Davide, Taffurelli, Giovanni, Montroni, Isacco, Colombo, Francesco, Danelli, Piergiorgio, Bondurri, Andrea, Maffioli, Anna, Bonomi, Alessandro, Pezzoli, Isabella, Cammarata, Francesco, Goletti, Orlando, Molteni, Mattia, Assisi, Alberto, Quartierini, Giorgio, Da Lio, Corrado, Verdi, Daunia, Mondi, Isabella, Peluso, Claudia, Macchi, Lorenzo, Tanzanu, Marta, Zanzi, Federico, Pellegrini, Sara, Andreuccetti, Jacopo, D'Alessio, Rossella, Pignata, Giusto, De Capua, Michele, Canfora, Ilaria, Ottaviani, Luca, Lepiane, Pasquale, Balla, Andrea, De Carlo, Antonio, Saraceno, Federica, Scaramuzzo, Rosa, Guida, Anna, Aguzzi, Daniele, Bellora, Paolo, Gentilli, Sergio, Monni, Manuela, Nikaj, Herald, Cillara, Nicola, Cannavera, Alessandro, Deserra, Antonello, Margiani, Carla, Cabula, Roberta, Dettori, Manuela, Gramignano, Giulia, Lezoche, Giovanni, Ortenzi, Monica, Orlandoni, Elena S, Curzi, Federica, Vitali, Francesca, Capomagi, Perla, Palmieri, Miriam, Giuffrida, Mario, Del Rio, Paolo, Bonati, Elena, Loderer, Tommaso, Cozzani, Federico, Rossini, Matteo, Agnesi, Stefano, Capolupo, Gabriella T, Caricato, Marco, Carannante, Filippo, Mascianà, Gianluca, Marrelli, Martina, Miacci, Valentina, Lauricella, Sara, Tonini, Valeria, Cervellera, Maurizio, Pisconti, Salvatore, Lozito, Concetta, Shahu, Juliana, Mongelli, Claudia, Morelli, Giulia, Sartarelli, Lodovico, Sica, Giuseppe S, Siragusa, Leandro, Bagaglini, Giulia, Sensi, Bruno, Guida, Andrea M, Franceschilli, Marzia, Vinci, Danilo, Taddei, Antonio, Risaliti, Matteo, Bartolini, Ilenia, Ringressi, Maria N, Tirloni, Luca, Laface, Letizia, Abate, Emmanuele, Casati, Massimiliano, Gobbi, Pietro, Opocher, Enrico, Mariani, Nicolò M, Pisani Ceretti, Andrea, Giovenzana, Marco, Giuliani, Beatrice, Sironi, Martina, Grossi, Ugo, Zanus, Giacomo, Aniello Santoro, Giulio, Brizzolari, Marco, De Leo, Eugenio, Novello, Simone, Aquilino, Krizia, Milardi, Francesco, Olmi, Stefano, Uccelli, Matteo, Bonaldi, Marta, Cesana, Giovanni C, Bindi, Marco, Galleano, Raffaele, Langone, Antonio, Botto, Massimiliano, Franceschi, Angelo, Gambino, Elena, Ronconi, Maurizio, Casiraghi, Silvia, Casole, Giovanni, Ciulla, Salvatore L, Terrosu, Giovanni, Calandra, Sergio, Scarpa, Edoardo, Cherchi, Vittorio, Calini, Giacomo, Martinuzzo, Lisa, Clocchiatti, Lucrezia, Muschitiello, Davide, Romanzi, Andrea, Vignati, Barbara, Vannelli, Alberto, Scolaro, Roberta, Milanesi, Maria, Rossi, Fabrizio, Canonico, Giuseppe, Anastasi, Alessandro, Nelli, Tommaso, Barlettai, Marco, Fratarcangeli, Riccardo, Di Martino, Carmela, Damigella, Andrea, Adinolfi, Elvira, Birindelli, Arianna, Taglietti, Lucio, Dester, Sara E, Fleres, Francesco, Cucinotta, Eugenio, Viscosi, Francesca, Biondo Santino, Antonio, Badessi, Giorgio, Catarsini, Nivia, Mazzeo, Carmelo, Rega, Daniela, Delrio, Paolo, Cervone, Carmela, Aversano, Alessia, De Franciscis, Silvia, Di Marzo, Massimiliano, Marra, Bruno, Pace, Ugo, Amato, Antonio, Batistotti, Paola, Mina, Elisa, Serventi, Alberto, Lapolla, Pierfrancesco, Mingoli, Andrea, Sapienza, Paolo, Brachini, Gioia, Cirillo, Bruno, Fiori, Enrico, Crocetti, Daniele, Clementi, Ilaria, Martines, Gennaro, Picciariello, Arcangelo, Tomasicchio, Giovanni, Dibra, Riger, Trigiante, Giuseppe, Rinaldi, Marcella, Lantone, Giuliano, Porcu, Alberto, Perra, Teresa, Scanu, Antonio M, Feo, Claudio F, Fancellu, Alessandro, Cossu, Maria L, Ginesu, Giorgio C, Patriti, Alberto, Coletta, Diego, Petrelli, Filippo, Greco, Paola A, Spadoni, Claudia, Cassiani, Giovanna, Bianchini, Federica, Arganini, Marco, Bianchini, Matteo, Perotti, Bruno, Palmeri, Matteo, Scabini, Stefano, Deiana, Selene, Carganico, Giacomo, Pertile, Davide, Soriero, Domenico, Fioravanti, Emanuela, Sperotto, Beatrice, Nardo, Bruno, Paglione, Daniele, Crocco, Veronica, Doni, Marco, Osso, Mariasara, Perri, Roberto, Sampietro, Gianluca M, Corbellini, Carlo, Lorusso, Leonardo, Manzo, Carlo A, Cigognini, Maria, Baldi, Caterina, Palomba, Giuseppe, Aprea, Giovanni, Capuano, Marianna, Basile, Raffaele, Tutino, Roberta, Massani, Marco, Marinelli, Laura, Canitano, Nicola, Pilia, Tiziana, Podda, Mauro, Pisanu, Adolfo, Murzi, Valentina, Incani, Silvia, Frongia, Federica, Esposito, Giuseppe, Luglio, Gaetano, Tropeano, Francesca P, Pagano, Gianluca, Spina, Eduardo, De Simone, Giuseppe, Cricrì, Michele, Catena, Fausto, Vallicelli, Carlo, Zanini, Nicola, Ronconi, Diana, Favi, Francesco, Mazzucchelli, Carlo, Convertini, Girolamo, Vincenti, Leonardo, Andriola, Valeria, Bizzoca, Cinzia, Feo, Carlo V, Fabbri, Nicolò, Fazzin, Marta, Pesce, Antonio, Gennari, Silvia, Torchiaro, Marco, Severi, Silvia, Frontali, Alice, Bracchetti, Greta, Granieri, Stefano, Cotsoglou, Christian, Carlini, Massimo, Lisi, Giorgio, Spoletini, Domenico, Mastrangeli, Maria R, Campanelli, Michela, Manigrasso, Michele, Milone, Marco, De Palma, Giovanni D, Vertaldi, Sara, Chini, Alessia, Maione, Francesco, Marello, Alessandra, Selvaggi, Francesco, Sciaudone, Guido, Selvaggi, Lucio, Menegon Tasselli, Francesco, Fuschillo, Giacomo, Oddis, Lidia, Grande, Simona, Grande, Michele, Ascanelli, Simona, Chimisso, Laura, Aisoni, Filippo, Rossin, Eleonora, Pepe, Francesco, Marchetti, Francesco, Picardi, Biagio, Rossi, Stefano, Rossi Del Monte, Simone, Picarelli, Matteo, Muttillo, Irnerio A, Ratto, Carlo, Marra, Angelo A, Parello, Angelo, Litta, Francesco, Campennì, Paola, De Simone, Veronica, Pata, Francesco, Riboni, Cristiana, Rausa, Emanuele, and Celentano, Valerio

Subjects
Adult, Male, Settore MED/18 - CHIRURGIA GENERALE, Otros calificadores::/diagnóstico [Otros calificadores], Hospitals, Community, colorectal cancer, Community, advanced stage, COVID-19 (Malaltia), Cohort Studies, Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms [DISEASES], Retrospective Studie, Other subheadings::/diagnosis [Other subheadings], virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Humans, Pandemics, Aged, Retrospective Studies, Pandemic, SARS-CoV-2, COVID-19, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], General Medicine, neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales [ENFERMEDADES], Hospitals, Recte - Càncer - Diagnòstic, Settore MED/18, Italy, Còlon - Càncer - Diagnòstic, Cohort Studie, Colorectal Neoplasms, Human
Abstract

ImportanceDelays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis.ObjectiveTo evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer.Design, Setting, and ParticipantsThis retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery.ExposuresAny type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections.Main Outcomes and MeasuresThe primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable.ResultsA total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95% CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95% CI, 1.15-1.53; P P = .03).Conclusions and RelevanceThis cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients.

Published
2022

25. 2D Numerical Simulations of HTS Cable-in-Conduit Conductor Cables

Author

De Marzi, Gianluca, Celentano, Giuseppe, Augieri, Andrea, Marchetti, Marcello, Vannozzi, Angelo, Italian National agency for new technologies, Energy and sustainable economic development [Frascati] (ENEA), and Université de Lorraine

Subjects
Critical current, Finite element Model, Superconducting Cable, HTS stack, A Formulation, [SPI.NRJ]Engineering Sciences [physics]/Electric power, T Formulation, Current distribution
Abstract

International audience; Among the designs of high-temperature superconducting (HTS) cables considered for fusion magnet applications, the Twisted Stacked Tape Cable-in-Conduit-Conductor (TSTC-CICC) has gained considerable interest due to its easy manufacturing process, very high tape length usage, and flexibility capabilities. Over the past decade, ENEA has launched several experimental campaigns aimed primarily at studying the electromechanical capabilities of these TSTC-CICCs. In order to clarify different aspects of the experimental results, we have developed a 2D finite element (FE) model based on the recently proposed T-A formulation. The simulations have been implemented using a commercial FE analysis, solver and multiphysics simulation software. Such FE model includes the contact resistance of the electrical terminations used to inject the current and takes into account the angular dependence of the critical current on the local magnetic field. This 2D model allows to reproduce the experimental V-I results obtained in TSTC-CICCs with excellent agreement. Furthermore, the numerical simulations have allowed to deepen the understanding of those mechanisms that govern the current distribution inside the cable. The numerical model will be used to analyze the ac losses of a fully energized cable, to improve the capabilities of existing designs and to find an optimal configuration.

Published
2021

42. Multisession Radiosurgery for Sellar and Parasellar Benign Meningiomas

Author

Marchetti, Marcello, primary, Bianchi, Stefania, additional, Pinzi, Valentina, additional, Tramacere, Irene, additional, Fumagalli, Maria Luisa, additional, Milanesi, Ida Maddalena, additional, Ferroli, Paolo, additional, Franzini, Angelo, additional, Saini, Marco, additional, DiMeco, Francesco, additional, and Fariselli, Laura, additional

Published
2016
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43. Prospective study of carmustine wafers in combination with 6-month metronomic temozolomide and radiation therapy in newly diagnosed glioblastoma: preliminary results

Author

Salmaggi, Andrea, primary, Milanesi, Ida, additional, Silvani, Antonio, additional, Gaviani, Paola, additional, Marchetti, Marcello, additional, Fariselli, Laura, additional, Solero, Carlo Lazzaro, additional, Maccagnano, Carmelo, additional, Casali, Cecilia, additional, Guzzetti, Sara, additional, Pollo, Bianca, additional, Ciusani, Emilio, additional, and DiMeco, Francesco, additional

Published
2013
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45. Radiosurgery for pituitary adenomas: Monoinstitutional analysis.

Author

Marchetti, Marcello, Pinzi, Valentina, Fumagalli, Maria Luisa, Martin, Elena De, Morlino, Sara, Iezzoni, Cecilia, and Fariselli, Laura

Subjects
*PITUITARY tumors, *RADIOSURGERY, *INTRACRANIAL tumors, *SURGICAL excision, *DISEASE relapse, *HYPOPITUITARISM
Abstract

Introduction: Pituitary adenomas (PA) represent one of the most common intracranial pathologies, accounting for 10-20% of intracranial tumors. Although PA are histologically benign, the neurological and physiological consequences can be devastating, particularly if these tumors involve the anterior optic pathways. Surgery is the first line treatment in many cases. However, about 30% of patients require additional treatment after microsurgery for recurrent or residual tumors. Radiosurgery (RS) represents a viable option as adjuvant treatment following incomplete surgical resection, tumor recurrence, or failure of medical therapy. The RS literature data report tumor control rate higher than 90% at 10 years. However, the concern about the optic neuropathy may limit the single session radiosurgery (sRS) indications. The aim of this study is to retrospectively evaluate the efficacy and safety of multi-session radiosurgery (mSRS) for such cases. Materials and methods: Forty-two patients treated by means of mRS between 2011 and 2019 have been analyzed. All patients have at least a post RS radiological (MRI), endocrinological and ophthalmological follow-up. Results: The median age at the time of mSRS was 54 years. Twenty-six (62%) patients had evidence of partial or total hypopituitarism before mSRS. Visual defects were present in 66.7% of patients. The median followup was 29.5 months (range 6-110 months). The median tumour volume pre-mSRS was 7070 mm3 (range, 1339 - 74530 mm3 ). The mean prescription dose was 25 Gy in 5 fractions. After the treatment, 33 patients (78,6 %) have stable disease, 7 (16.6 %) showed partial response; one patient (2.4%) had a complete response; one patient (2.4) experienced a tumor progression. One patient (2.4 %) developed mild visual worsening. None of the analyzed patients developed new or worsened hypopituitarism. Conclusion: Our results suggest that mRS can be proposed as a safe and effective treatment modality for patients suffering from recurrent or residual pituitary adenomas. [ABSTRACT FROM AUTHOR]

Published
2022

46. Multisession compared to single-session radiosurgery to preserve the hearing in patients affected by sporadic vestibular schwannoma. The results from a prospective randomized clinical trial.

Author

Marchetti, Marcello, Cuccarini, Valeria, Tramacere, Irene, Cane, Irene, Ghielmetti, Francesco, Morlino, Sara, Pinzi, Valentina, Iezzoni, Cecilia, and Fariselli, Laura

Subjects
*ACOUSTIC neuroma, *CLINICAL trials, *RADIOSURGERY, *SCHWANNOMAS, *VESTIBULAR stimulation, *VOLUMETRIC analysis, *FACIAL paralysis, *ACOUSTIC stimulation
Abstract

Objective: Radiosurgery for acoustic schwannoma is continuously increasing. The attention is actually focusing on the hearing function sparing. The aim of the present study is to investigate about potential advantages of multisession radiosurgery(mRS) compared to single session radiosurgery(sRS) in terms of hearing preservation in patients with serviceable hearing. Patients and methods: The primary end-point of this prospective, randomized clinical trial is the difference in term of hearing preservation between patients treated with mRS and sRS because of a sporadic acoustic neuroma. The conditions for patient eligibility are: -sporadic acoustic neuroma diagnosis. -Age≥18 years old -KPS≥70 -Serviceable hearing: class A/B (AAOHNS classification) -Written consent All the enrolled patients are clinically, radiologically and audiometrically evaluated. The volumetric analysis of the tumor is always performed. Results: One-hundred-eight patients were enrolled and treated according to the study protocol. Three patients refused the treatment after the randomization process and in 4 cases the eligibility criteria were not satisfied, 101 patient were therefore evaluated. Forty-seven patients had a 12Gy sRS on a mean volume of 1.9cc; 54 patients had a mRS (18Gy/3 fractions) on mean volume of 1.7cc. After a mean follow-up period of 34 months (range 4-97 months) 59 patients (58%) maintained a serviceable hearing. No significant differences were observed between sRS and mRS in term of hearing preservation. Particularly, forty-two patients (42%) experienced a hearing deterioration (class C and D); with 21 patients undergoing sRS and 21 mRS. The most important predictor factor was the pre-treatment haring status. The treatment related toxicity was always mild. The most common side effect was a transient balance impairment. Along all the observation period three patients required surgery because of tumor progression. One patient had an excellent surgical outcome (HB1); one had an intermedium outcome (HB2-3),while the third developed a complete facial palsy (HB4). In all these cases, the histology confirmed the radiological diagnosis of schwannoma. Conclusions: At our knowledge, the present clinical trial is the first one comparing two different radiosurgical regimens in terms of hearing sparing. While we are waiting for a longer follow-up period, the preliminary results from this study suggest that mRS has no advantages compared to sRS in terms of hearing preservation. Our preliminary results suggest that the better is the auditory function at the moment of the treatment, the more probable is the hearing preservation. The volumetric analysis confirms the very good post radiosurgery tumor control rate. [ABSTRACT FROM AUTHOR]

Published
2022

47. Stereotactic radiosurgery and fractionated stereotactic radiosurgery as adjuvant treatment for resected brain metastases: A single center series.

Author

Pinzi, Valentina, Romeo, Anna, Marchetti, Marcello, morlino, Sara, Tramacere, Irene, and Fariselli, Laura

Subjects
STEREOTACTIC radiosurgery, KARNOFSKY Performance Status, PROGRESSION-free survival, NON-small-cell lung carcinoma, SURGICAL excision
Abstract

Post-operative SRS and fSRS are effective and safe approaches commonly used to treat BMs. In our series, 71 patients (pts) who underwent partial or total resection for BM and adjuvant SRS or fSRS with Cyberknife (CK) were retrospectively analyzed. Pts with prior whole brain irradiation (WBRT) or leptomeningeal disease (LMD) were excluded. The main represented histologies were breast and non-small cell lung cancers. Almost all pts had no ongoing systemic therapies at the moment of CK. Twenty-nine pts underwent SRS (14-20 Gy in single fraction), 42 fSRS (21-24 Gy in 3 fractions). They all had a Karnofsky performance status ≥ 70. The cumulative 1-year local control (LC) rate and progression free survival (PFS) were 78.5% and 87%, respectively. The cavity recurrence rate was 38% versus (vs) 17% for SRS and fSRS group, respectively (p=0.15), with a median time to progression of 17 months vs 12. Only 4 events of late brain radiation necrosis (RN) were registered, all G2 graded according to CTCAE v.5. No other G2 toxicities were reported. The median overall survival (OS) was 47 months, with a 12-months OS rate of 83%. A 20% rate of LMD was reported; the type of surgical resection of the BM (piecemeal vs en-bloc), and the inclusion or exclusion of the surgical corridor leading to the cavity in PTV volume did not show a statistically significant correlation with the onset of LMD. A better trend for PFS emerged for pts with a waiting time from surgery to treatment ≤ 45 days vs > 45 days (p=0.07). PTV volume, dose prescription, fractionation and histology seemed not to affect LC, nor OS. A DS-GPA score ≥ 3 vs < 3, an extracranic (EXC) disease absent or oligometastatic vs present not oligometastatic, and an EXC disease at last follow-up stable vs in progression were found to be significantly correlated with a better OS (p=0.0000, p=0.02, p=0.0009, respectively). We can confirm that both SRS and fSRS are effective and safe approaches in the adjuvant setting of resected BMs; dose prescription and fractionation must be selected according to PTV volume. With regards to OS, they are a valid alternative to WBRT. Further data are needed to better assess the role of target delineation, waiting time from surgery to irradiation, and systemic therapies to improve pts outcomes. [ABSTRACT FROM AUTHOR]

Published
2022

48. Assessment of post-radiosurgery response for intracranial meningiomas: is volumetric analysis the proper outlook?

Author

Pinzi, Valentina, Viola, Anna, Tramacere, Irene, morlino, Sara, De Martin, Elena, Marchetti, Marcello, and Fariselli, Laura

Subjects
VOLUMETRIC analysis, BRAIN tumors, STEREOTACTIC radiotherapy, MAGNETIC resonance imaging, PROGRESSION-free survival, STEREOTACTIC radiosurgery
Abstract

Defining both a threshold of progression and the optimal endpoint for clinical trials on radiation therapy for benign meningiomas is difficult. In fact, the growth rates of meningiomas are variable, overall survival (OS) is often very long, and progression-free survival (PFS) requires long-term follow-up. To assess radiation response various strategies have been evaluated. Although most of the published studies describe the criteria for control assessment, there is no uniform definition. Volumetric analysis of magnetic resonance imaging (MRI) imaging has been proposed as the most appropriate method for detecting change in slowly evolving brain tumors. In this scenario, we analyzed this method in post-radiosurgical intracranial meningiomas as part of a prospective clinical trial. The primary aim of the present study was to validate a volumetric assessment method after fractionated radiosurgery or fractionated stereotactic radiotherapy (fSRS) for benign intracranial meningiomas. Secondary aims were evaluation of a cut-off to define progression, stable or partial response and volumetric response after fSRS treatment. To validate the volumetric assessment, we appraised delta values (ΔV) of volume variations. To evaluate tumor response, a volumetric analysis has been performed by means of co-registration of each follow-up MRI on baseline MRI and contouring of the lesion on each post-treatment exam. Overall, 150 patients were considered eligible for the purpose of the volumetric analysis. After a mean followup of 60.5 months (SD 17.45, median 59, range 14–101 months) the median reduction in tumor volume was -21.26%, (range -82.26% to 91.36%) to reach a median final tumor of 8.65 cm3 (range 0.38 - 56.28 cm3) that differed significantly from baseline (p < 0.001). Among 150 irradiated meningiomas, 75 (50%) ultimately regressed, 67 (45%) remained stable, and 8 (5%) progressed. Baseline volumes were similar in each group (p = 0.092), and final volumes were significantly larger in tumors that progressed (p < 0.001) supporting the use of a ΔV of 20% as a cutoff for progression. The mean %ΔV became significantly different by 10 months, with continued diversion up to 36 months. Our results suggest quantitative volumetric assessment of tumor response to fSRS may help clinicians to better understand early response profiles and provide a valuable tool for patient management following fSRS for meningiomas. [ABSTRACT FROM AUTHOR]

Published
2022

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