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45 results on '"Marchesi, Simona"'

2. Human endothelial impairment in sepsis

Author

Vaudo, Gaetano, Marchesi, Simona, Siepi, Donatella, Brozzetti, Matteo, Lombardini, Rita, Pirro, Matteo, Alaeddin, Abdalkader, Roscini, Anna Rita, Lupattelli, Graziana, and Mannarino, Elmo

Published
2008
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33. Early vascular damage in primary hypoalphalipoproteinemia

Author

Vaudo, Gaetano, primary, Marchesi, Simona, additional, Lupattelli, Graziana, additional, Pirro, Matteo, additional, Pasqualini, Leonella, additional, Roscini, Anna Rita, additional, Siepi, Donatella, additional, Schillaci, Giuseppe, additional, and Mannarino, Elmo, additional

Published
2003
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40. Relevance of homocysteine on brachial flow-mediated vasodilatation and carotid and femoral intima-media thickness in patients with hypercholesterolemia

Author

Vaudo, Gaetano, Marchesi, Simona, Siepi, Donatella, Bagaglia, Francesco, Paltriccia, Rita, Pirro, Matteo, Schillaci, Giuseppe, Lupattelli, Graziana, and Mannarino, Elmo

Subjects
*HYPERCHOLESTEREMIA, *ISOPENTENOIDS, *VASODILATION, *HOMOCYSTEINE
Abstract

The relevance of homocysteine to brachial flow-mediated vasodilatation and carotid and femoral intima-media thickness was investigated in 192 patients with hypercholesterolemia. Low-density lipoprotein cholesterol and homocysteine levels predicted brachial flow-mediated vasodilatation, internal carotid mean intima-media thickness, and intima-media thickening at all femoral sites. Homocysteine levels seem to be an additional factor in the initial atherosclerotic damage of patients with hypercholesterolemia. [Copyright &y& Elsevier]

Published
2004
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42. Prostaglandin E1Improves Endothelial Function in Critical Limb Ischemia

Author

Marchesi, Simona, Pasqualini, Leonella, Lombardini, Rita, Vaudo, Gaetano, Lupattelli, Graziana, Pirro, Matteo, Schillaci, Giuseppe, and Mannarino, Elmo

Abstract

Prostaglandin E1(PGE1) may relieve rest pain and heal ulcers in critical limb ischemia, but its mechanism of action is still incompletely understood. To investigate the effects of PGE1treatment on endothelial function evaluated as brachial artery flow-mediated vasodilation (FMV) and on soluble adhesion molecule plasma levels (vascular adhesion molecule-1 sVCAM-1 and intercellular adhesion molecule-1 sICAM-1), 12 patients with critical limb ischemia were treated with daily PGE1IV infusion (alprostadil 60 g) for 2 weeks. FMV and plasma sICAM-1 and sVCAM-1 concentrations were determined at baseline, after the first infusion, and after 1 and 2 weeks. Compared with 30 healthy control subjects, patients had higher baseline sVCAM-1 (2.402 ± 296 ng/ml vs 972 ± 117 ng/ml) and sICAM-1 levels (464 ± 51 ng/ml vs 206 ± 37 ng/ml, both p < 0.05) and lower FMV (1.0 ± 1.1 vs 5.6 ± 1.6, p < 0.05). sICAM-1 concentration progressively decreased with treatment (from 464 ± 51 ng/ml to 326 ± 56 ng/ml, 288 ± 42 ng/ml, and 279 ± 44 ng/ml after the first dose and, respectively, after 1 and 2 weeks; all p < 0.05). sVCAM-1 showed a reduction after 2 weeks (from 2.402 ± 296 ng/ml to 1.916 ± 176 ng/ml; p < 0.05). FMV improved after 1 and 2 weeks (from 1.0 ± 1.1 to 3.1 ± 0.6 and 5.2 ± 2.1, both p < 0.05). In conclusion, treatment with PGE1determines a significant improvement in endothelial function in patients with critical limb ischemia.

Published
2003

45. Relationship between dorsal ganglion cysts of the wrist and intraosseous ganglion cysts of the carpal bones.

Author

Van den Dungen S, Marchesi S, Ezzedine R, Bindou D, and Lorea P

Subjects
Bone Cysts diagnostic imaging, Bone Cysts etiology, Carpal Bones diagnostic imaging, Carpal Bones surgery, Ganglion Cysts etiology, Humans, Prevalence, Prospective Studies, Radiography, Bone Cysts pathology, Carpal Bones pathology, Ganglion Cysts complications, Ganglion Cysts diagnostic imaging, Wrist diagnostic imaging, Wrist pathology
Abstract

Soft tissue ganglion cysts are the most common benign tumours of the wrist; their pathogenesis remains controversial. We prospectively screened the radiographic appearance of the wrists of 51 patients presenting to a single surgeon with dorsal wrist ganglions during a one-year period. Postero-anterior and lateral radiographs were systematically performed looking for possible associated intraosseous ganglion cysts. There were 51 dorsal soft tissue ganglion cysts in 51 patients. We detected 29 associated intraosseous ganglia in 24 patients (47%): 16 ganglia in the lunate bone (55%), 5 in the capitate bone, 7 in the scaphoid and 1 in the trapezoid. Mean size of the intraosseous ganglia was 3 mm (range, 2 to 5 mm). This high prevalence of intraosseous ganglia in association with soft tissue ganglia has to our knowledge never been reported previously. A common aetiology for these two types of ganglion cysts may explain this high association rate.

Published
2005

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