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4. Amylose cardiaque scintigraphique après chirurgie du canal carpien : facteurs de risque démographiques, chirurgicaux et histologiques

Author

Delbarre, M.A., primary, Marchal, E., additional, Blanc-Durand, P., additional, Hubaut, M.A., additional, Balcaen, T., additional, Hanquiez, T., additional, Rattier, S., additional, Moughabghab, M., additional, Duhaut, P., additional, Buob, D., additional, Tribouilloy, C., additional, and Schmidt, J., additional

Published
2023
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6. Baseline [18F]FDG PET features are associated with survival and toxicity in patients treated with CAR T cells for large B cell lymphoma.

Author

Marchal, E., Palard-Novello, X., Lhomme, F., Meyer, M. E., Manson, G., Devillers, A., Marolleau, J. P., Houot, R., and Girard, A.

Subjects
*B cells, *B cell lymphoma, *T cells, *OVERALL survival, *CYTOKINE release syndrome, *BODY surface area
Abstract

Purpose: Chimeric antigen receptor (CAR) T cells have established themselves as an effective treatment for refractory or relapsed large B cell lymphoma (LBCL). Recently, the sDmax, which corresponds to the distance separating the two farthest lesions standardized by the patient's body surface area, has appeared as a prognostic factor in LBCL. This study aimed to identify [18F]FDG-PET biomarkers associated with prognosis and predictive of adverse events in patients treated with CAR T cells. Methods: Patients were retrospectively included from two different university hospitals. They were being treated with CAR T cells for LBCL and underwent [18F]FDG-PET just before CAR T cell infusion. Lesions were segmented semi-automatically with a threshold of 41% of the maximal uptake. In addition to clinico-biological features, sDmax, total metabolic tumor volume (TMTV), SUVmax, and uptake intensity of healthy lymphoid organs and liver were collected. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method. The occurrence of adverse events, such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), was reported. Results: Fifty-six patients were included. The median follow-up was 9.7 months. Multivariate analysis showed that TMTV (cut-off of 36 mL) was an independent prognostic factor for PFS (p < 0.001) and that sDmax (cut-off of 0.15 m−1) was an independent prognostic factor for OS (p = 0.008). Concerning the occurrence of adverse events, a C-reactive protein level > 35 mg/L (p = 0.006) and a liver SUVmean > 2.5 (p = 0.027) before CAR T cells were associated with grade 2 to 4 CRS and a spleen SUVmean > 1.9 with grade 2 to 4 ICANS. Conclusion: TMTV and sDmax had independent prognostic values, respectively, on PFS and OS. Regarding adverse events, the mean liver and spleen uptakes were associated with the occurrence of grade 2 to 4 CRS and ICANS, respectively. Integrating these biomarkers into the clinical workflow could be useful for early adaptation of patients management. [ABSTRACT FROM AUTHOR]

Published
2024
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10. A fast point-of-care PCR test for infectious diseases, based on aerosol capturing

Author

Verbruggen, B, primary, Raymenants, J, additional, Stakenborg, T, additional, Paeps, F, additional, Marchal, E, additional, Jauregui Uribe, A, additional, Duthoo, W, additional, Kossarev, A, additional, Dam, T, additional, El Jerrari, Y, additional, Sergio Wiederkehr, R, additional, Luo, Z, additional, Peca, M, additional, Mcrea, L, additional, Darriba Frederiks, A, additional, Yurt, A, additional, Ongena, K, additional, Hanifa, R, additional, Van Duppen, J, additional, El Mahmoudi, S, additional, Humbert, M, additional, Emmen, E, additional, Jones, B, additional, Taher, A, additional, Lambrechts, A, additional, André, E, additional, and Peumans, P, additional

Published
2022
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11. Détection automatique des amyloses cardiaques en scintigraphie osseuse à l’aide du machine learning

Author

Delbarre, M.A., primary, Girardon, F., additional, Blanc-Durand, P., additional, Hubaut, M.A., additional, Roquette, L., additional, Hachulla, E., additional, Semah, F., additional, Huglo, D., additional, Marchal, E., additional, El Esper, I., additional, Kharoubi, M., additional, Tribouilloy, C., additional, Lamblin, N., additional, Duhaut, P., additional, Itti, E., additional, Schmidt, J., additional, and Damy, T., additional

Published
2021
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17. The TAXINOMISIS Project: A multidisciplinary approach for the development of a new risk stratification model for patients with asymptomatic carotid artery stenosis

Author

Timmerman, N. Galyfos, G. Sigala, F. Thanopoulou, K. de Borst, G.J. Davidovic, L. Eckstein, H.-H. Filipovic, N. Grugni, R. Kallmayer, M. de Kleijn, D.P.V. Koncar, I. Mantzaris, M.D. Marchal, E. Matsagkas, M. Mutavdzic, P. Palombo, D. Pasterkamp, G. Potsika, V.T. Andreakos, E. Fotiadis, D.I. all partners of the TAXINOMISIS Consortium

Abstract

Introduction: Asymptomatic carotid artery stenosis (ACAS) may cause future stroke and therefore patients with ACAS require best medical treatment. Patients at high risk for stroke may opt for additional revascularization (either surgery or stenting) but the future stroke risk should outweigh the risk for peri/post-operative stroke/death. Current risk stratification for patients with ACAS is largely based on outdated rand-omized-controlled trials that lack the integration of improved medical therapies and risk factor control. Furthermore, recent circulating and imaging biomarkers for stroke have never been included in a risk stratification model. The TAXINOMISIS Project aims to develop a new risk stratification model for cerebrovascular complications in patients with ACAS and this will be tested through a prospective observational multicentre clinical trial performed in six major European vascular surgery centres. Methods and analysis: The risk stratification model will compromise clinical, circulating, plaque and imaging biomarkers. The prospective multicentre observational study will include 300 patients with 50%-99% ACAS. The primary endpoint is the three-year incidence of cerebrovascular complications. Biomarkers will be re-trieved from plasma samples, brain MRI, carotid MRA and duplex ultrasound. The TAXINOMISIS Project will serve as a platform for the development of new computer tools that assess plaque progression based on radiology images and a lab-on-chip with genetic variants that could predict medication response in individual patients. Conclusion: Results from the TAXINOMISIS study could potentially improve future risk stratification in patients with ACAS to assist personalized evidence-based treatment decision-making. © 2020 The Authors.

Published
2020

30. MÉLANGES

Author

Marchal, É.

Published
1873

39. L'importance des candidatures spontanées en France

Author

Bessy, Christian, Marchal, E., Riaucau, G., Institutions et Dynamiques Historiques de l'Economie (IDHE), École normale supérieure - Cachan (ENS Cachan)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Hétérochimie Fondamentale et Appliquée (LHFA), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Centre d'études de l'emploi (CEE), and Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)-Ministère du Travail, de l'Emploi et de la Santé

Subjects
[SHS.SOCIO]Humanities and Social Sciences/Sociology, emploi, candidature spontanée -France, [SHS.ECO]Humanities and Social Sciences/Economics and Finance
Abstract

Deux enquêtes récentes convergent pour mettre en évidence la place primordiale occupée en France par les candidatures spontanées parmi les modes de recrutement. À l'analyse, il apparaît que ce canal est une source d'embauche privilégiée pour les jeunes, les personnes peu diplômées et celles embauchées en contrat à durée déterminée. En outre, ce mode de recrutement est particulièrement utilisé par les grands établissements. La comparaison avec l'Espagne et le Royaume-Uni montre qu'il s'agit d'une spécificité française, le poids des candidatures spontanées étant beaucoup moins important ailleurs, au profit des relations en Espagne et des annonces d'offres d'emploi ou des agences de recrutement au Royaume-Uni. La répartition des canaux de recrutement dans chaque pays donne un éclairage original sur le fonctionnement des différents marchés du travail.

Published
2007

40. [From little to big announcements : the market of the job offers since 1960]

Author

Marchal, E., Torny, Didier, Inconnu, Sociétés, Techniques, Environnement, Politiques Economiques (STEPE), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
presse d'information, espace et société, [SHS] Humanities and Social Sciences, RECRUTEMENT, Environnement, espace et société, Environnement, [SHS]Humanities and Social Sciences
Abstract

Entre 1960 et 2000, les annonces d'emploi publiées dans la grande presse ont changé. Des petites annonces nombreuses, sommaires, invitant les demandeurs d'emploi à entrer directement en contact avec les entreprises qui embauchent, on est passé aux "grandes annonces", élaborées par des intermédiaires, professionnels du recrutement ou de la communication, et "mises en scène" sur le plan du message et du visuel. L'information véhiculée par ces annonces en est-elle plus complète ? Les auteurs montrent qu'une rédaction plus sophistiquée des annonces accroît leur degré de sélectivité et sollicite fortement les compétences interprétatives des lecteurs. Loin de favoriser la transparence sur les marchés du travail concernés, cette évolution accroît plutôt les déséquilibres de l'information entre entreprises et candidats au recrutement. Elle pourrait être contrecarrée par la formalisation nouvelle de la collecte de renseignements que nécessite la publication des annonces sur internet.

Published
2003

41. L'hydroacoustique, Méthode d'étude de la distribution spatiale et de l'abondance des peuplements de poissons lacustres

Author

Guillard, Jean, Marchal, E., Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques (CARRTEL), Institut National de la Recherche Agronomique (INRA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), D. Gerdeaux, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2001

42. Les espaces de l'halieutique

Author

Ménard, Frédéric, Ravier, C., Fonteneau, Alain, Gaertner, Daniel, Marchal, E., Gascuel, D. (ed.), Chavance, Pierre (ed.), Bez, N. (ed.), and Biseau, A. (ed.)

Subjects
TECHNIQUE DE PECHE, PECHE HAUTURIERE, SENNE, PECHE THONIERE
Published
2000

44. Application des dosages par immunoéphélémétrie microparticulaire des caséines alpha, beta et kappa à l'évaluation de la qualité du lait, de sa production à sa valorisation fromagère

Author

Montagne, P., Cuilliere, M.L., Marchal, E., El Bari, N., Montagne, Marjorie, Benali, M., Faure, G., Duheille, J., Humbert, G., LINDEN, G., Heurtaux, N., Blesche, J.L., Gosselin, David, Desmares, A., Delahaye, D., ProdInra, Migration, Laboratoire des BioSciences de l'Aliment (LBSA), and Institut National de la Recherche Agronomique (INRA)-Université Henri Poincaré - Nancy 1 (UHP)

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences, [SDV.SA] Life Sciences [q-bio]/Agricultural sciences, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1995

45. Microparticle-enhanced nephelometric immunoassay of plasminogen in bovine milk

Author

Marchal, E., Haissat, S., Montagne, P., Cuilliere, M.L., Béné, M.C., Faure, G., Humbert, G., LINDEN, G., ProdInra, Migration, Laboratoire des BioSciences de l'Aliment (LBSA), and Institut National de la Recherche Agronomique (INRA)-Université Henri Poincaré - Nancy 1 (UHP)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], IMMUNOEPHELOMETRIE, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1995

46. A whirling ecosystem in the equatorial Atlantic

Author

Menkes, Christophe, Kennan, Sc, Flament, Pierre, Dandonneau, Y, Masson, S, Biessy, B, Marchal, E, Eldin, G, Grelet, J, Montel, Y, Morliere, A, Lebourges-dhaussy, A, Moulin, C, Champalbert, G, Herbland, Alain, Menkes, Christophe, Kennan, Sc, Flament, Pierre, Dandonneau, Y, Masson, S, Biessy, B, Marchal, E, Eldin, G, Grelet, J, Montel, Y, Morliere, A, Lebourges-dhaussy, A, Moulin, C, Champalbert, G, and Herbland, Alain

Abstract

[1] The equatorial Pacific and Atlantic oceans exhibit remarkable meridional undulations in temperature and chlorophyll fronts visible from space over thousands of kilometers and often referred to as tropical instability waves. Here, we present new observations of an ecosystem ranging through three trophic levels: phytoplankton, zooplankton and small pelagic fish whirling within a tropical vortex of the Atlantic ocean and associated with such undulations. Cold, nutrient and biologically rich equatorial waters are advected northward and downward to form sharp fronts visible in all tracers and trophic levels. The equatorward recirculation experiences upwelling at depth, with the pycnocline and ecosystem progressively moving toward the surface to reconnect with the equatorial water mass. The observations thus indicate that it is a fully three-dimensional circulation that dominates the distribution of physical and biological tracers in the presence of tropical instabilities and maintains the cusp-like shapes of temperature and chlorophyll observed from space.

Published
2002
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49. Valeur pronostique et prédictive de la TEP/TDM au [18F]FDG chez les patients traités par CAR-T cellspour un lymphome B diffus à grandes cellules

Author

Marchal, E., Novellox, E. Palard, Lhomme, F., Manson, G., Marolleau, J.P., Meyer, M.E., Houot, R., and Girard, A.

Abstract

Les CAR-T cells, autorisés depuis 2018 en France, ont transformé la prise en charge du lymphome B diffus à grandes cellules (LBDGC) réfractaire ou en rechute. Parmi les effets indésirables de ce traitement, les syndromes de relargage cytokinique et neurotoxiques sont fréquents et parfois graves. Plusieurs paramètres extraits de la TEP au [18F]FDG pré-thérapeutique chez les patients traités par CAR-T cellspour un LBDGC (comme le volume métabolique (TMTV) ou la distance séparant les deux lésions les plus éloignées (Dmax)) sont récemment apparus comme des facteurs pronostiques dans le LBDGC. L’objectif de notre étude est de confirmer ou non leur valeur pronostique, mais également d’évaluer leur valeur prédictive concernant les effets indésirables des CAR-T cells.

Published
2023
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50. On the relationship between scattering layer, thermal structure and tuna abundance in the eastern atlantic equatorial current system

Author

Marchal, E, Gerlotto, F, Stequert, B, Marchal, E, Gerlotto, F, and Stequert, B

Abstract

A migrating Sound Scattering Layer (SSL) was observed in the Eastern Atlantic equatorial system during warm and cool seasons. Averaged column scattering strength was nearly the same during daytime at 350-400 m depth and during night-time close to the surface. The depth of the nocturnal SSL was correlated with the depth of the thermocline. In the warm stable season, the maximum column scattering strength was found south of the equator in a dome shaped structure. In the cool season, the maximum was found at the northern convergence where the thermocline was well-marked, whereas upwelled waters were acoustically poor. For the warm season, this pattern is consistent with the distribution of chlorophyll, zooplankton and micronekton. For the cool season, it fits also rather well, except for the net-sampled micronekton : this discrepancy could be related to the poor efficiency of the net in sampling adequately a thin layer. Finally, SSL strength coincides well with tuna catch distribution in this area, suggesting a trophic relationship.

Published
1993

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