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The ENVISION project (2019-2021) supported the development of a participatory approach to the management of PAs, inclusive conservation, with the aim of improving biodiversity and human well-being. Inclusive conservation is an approach for accommodating and balancing different stakeholder visions and values for PA management to achieve socially relevant and environmentally sustainable outcomes in protected areas. This brief provides a current description of the international policy landscape for conservation and protected areas and outlines a set of tools to enhance inclusive management of protected areas. These tools have been developed and applied across four case study areas by a team of international researchers.

The Sierra de Guadarrama National Park is located in the Central MountainSystem of the Iberian Peninsula. It was established in 2013, becomingSpain's newest national park. This National Park covers 34,000 hectaresacross the regions of Madrid (64% of the territory) and Castilla y León.The National Park’s authority in the areais intertwined with the different scales of decision-making of multiplestate administrations. To compound this complexity, the Sierra deGuadarrama is the second most visited national park in Spain, and thereare a great variety of local stakeholders engaged in diverse activitiessuch as outdoor sports, extensive livestock farming, and environmentalconservation, education and research. The multiple and sometimescompeting uses and values create social tensions around how the parkshould be governed.Researchersareconducting research to provide practical guidance to understand, navigateand consider different visions, preferences, tensions, responsibilities andpower relations between stakeholders, in order to move towards bettersocial engagement in conservation decision-making.&nbsp

This report corresponds to ENVISION milestone 5.3., aiming to develop a workshop for participatory scenario planning to reflect on five possible future scenarios for the Sierra de Guadarrama National Park (Spain). The participatory scenario planning exercise involved a two-day online workshop with 45 participants, including decision-makers, researchers, local users, non-governmental organizations, and other social actors. On the basis of a common assessment of the current socio-ecological conditions and the factors driving change in recent years, they consideredwhat could happen in the next twenty years. The stakeholders discussed whether and how the area might continue to contribute to the quality of life of those who currently enjoy the ecosystem services it provides. Further, by identifying the advantages and disadvantages of the envisioned futurescenarios,who would lose or gain in the respective future scenarios was assessed. The stakeholdersprioritized several strategies to realize their desired futures for the National Park.

This deliverable corresponds to ENVISION task 5.1, aiming to identify the governance arrangements behind protected areas (PAs) management, as well as the strengths and gaps in coordination across involved institutions, through a case study in a European PA: The Sierra de Guadarrama National Park (Spain). Aquest lliurament correspon a la tasca 5.1 de ENVISION, l'objectiu de la qual és identificar els acords de governança que subjeuen a la gestió de les àrees protegides (AP), així com els punts forts i les llacunes en la coordinació entre les institucions implicades, a través d'un estudi de cas en un AP europeu: El Parc Nacional de la Serra de Guadarrama (Espanya). Esta entrega corresponde a la tarea 5.1 de ENVISION, cuyo objetivo es identificar los acuerdos de gobernanza que subyacen a la gestión de las áreas protegidas (AP), así como los puntos fuertes y las lagunas en la coordinación entre las instituciones implicadas, a través de un estudio de caso en un AP europeo: El Parque Nacional de la Sierra de Guadarrama (España).

In this paper, we develop a novel interpretation of the internal relationship between value, rent and finance, thereby enabling a new reading of the process of financialisation. As we argue, responding to the important question of how best to conceptualise the relationship between value and finance necessitates an understanding of the internal relations with a third moment, that of rent. We therefore develop a triadic understanding of these three interrelated moments. Crucially, we demonstrate that fictitious capital now actively pursues forms of rent, deepening the interrelationship between value, rent and finance. We conclude with a critical review of the literature on the financialisation of water, showing how the conceptual framework we develop sheds light upon the relations out of which water infrastructure has been financialised, as well as suggesting strategic entry points for its contestation.

Graphical abstract, We have previously reported a series of anilinoquinazoline derivatives as potent and selective biochemical inhibitors of the RET kinase domain. However, these derivatives displayed diminished cellular potency. Herein we describe further optimisation of the series through modification of their physicochemical properties, delivering improvements in cell potency. However, whilst cellular selectivity against key targets could be maintained, combining cell potency and acceptable pharmacokinetics proved challenging.

Deregulation of the receptor tyrosine kinase RET has been implicated in medullary thyroid cancer, a small percentage of lung adenocarcinomas, endocrine-resistant breast cancer and pancreatic cancer. There are several clinically approved multi-kinase inhibitors that target RET as a secondary pharmacology but additional activities, most notably inhibition of KDR, lead to dose-limiting toxicities. There is, therefore, a clinical need for more specific RET kinase inhibitors. Herein we report our efforts towards identifying a potent and selective RET inhibitor using vandetanib 1 as the starting point for structure-based drug design. Phenolic anilinoquinazolines exemplified by 6 showed improved affinities towards RET but, unsurprisingly, suffered from high metabolic clearance. Efforts to mitigate the metabolic liability of the phenol led to the discovery that a flanking substituent not only improved the hepatocyte stability, but could also impart a significant gain in selectivity. This culminated in the identification of 36; a potent RET inhibitor with much improved selectivity against KDR., Graphical abstract, Highlights • Novel anilinoquinazoline RET inhibitors have been prepared. • Phenolic moieties display enhanced potency but decreased metabolic stability. • Substitution patterns adjacent to the phenol improve metabolic stability. • These substituents deliver unanticipated improvements in selectivity. • Improvements in selectivity are explained through X-ray crystallographic studies.

International audience; Within the frame work of implementation of Directive 97/43, a French dosimetry campaign in diagnostic radiology was carried out, from April 2001 to February 2003, under supervision of a steering Committee, involving representatives of scientific and professional societies, of the Directorate-General for Nuclear Safety and Radiation Protection (DGSNR) and experts of the Institute of Radiation Protection and Nuclear Safety (IRSN). The aim was to assess patient dose associated to the standardized radiology procedures recommended by the "Société française de radiologie" and to determine national dose reference levels (DRL) in diagnostic radiology. On the basis of protocols and data sheets established by the "Société française de physique médicale" and the IRSN, measurements were performed by multidisciplinary team (radiologist, physicists and radiographer) in 24 volunteer centers. The treatment of measured and collected data was in charge of the IRSN. For each of the 8 examinations selected, (4 in Conventional Radiology (CR) and 4 in Computed Tomography (CT)), data and dose measurements were assessed for 20 adult patients in each center. In CR, the entrance surface dose for each exposure was measured on 1231 patients using thermoluminescent dosimeters. In CT, the weighted Computed Tomography Dose Index and the Dose-Length Product were calculated for 667 patients, on base of the procedure parameters and the scanner normalized dose index values. For each type of examination, mean dose values and third quartile values were determined: depending on the type of examination, the results are either similar or lower than 1996 European DRL. These results are analyzed according the dose influencing parameters. Despite the 24 involved hospitals were not randomly selected, this preliminary study emphasizes the feasibility and great interest of a larger campaign of measurements based on a precise statistical survey of radiological practices in order to determine French DRL and to facilitate their periodic review in a continuous process of unnecessary doses reduction. © 2004 EDP Sciences.; Dans le cadre des travaux de transposition en droit français de la directive 97/43 Euratom relative à la radioprotection des patients, une campagne nationale de dosimétrie en radiodiagnostic s’est déroulée entre avril 2001 et février 2003, à l’initiative conjointe des sociétés savantes et professionnelles, de la Direction générale de la Sûreté nucléaire et de la radioprotection (DGSNR) et de l’Institut de radioprotection et de sûreté nucléaire (IRSN). Son objectif était d’associer des niveaux de doses aux procédures radiologiques standardisées, élaborées dans une étape précédente par la Société française de radiologie, et d’engager une première étude pour la détermination de niveaux de référence diagnostiques (NRD) français. Sur la base de protocoles de mesures et de fiches d’informations établis par l’IRSN et la Société française de physique médicale, la campagne a reposé sur des équipes pluridisciplinaires (radiologue, physicien, technicien), dans 24 services de radiologie volontaires. Son organisation pratique, la centralisation des données et le traitement des résultats ont été assurés par l’IRSN. Pour les 8 examens sélectionnés (4 en radiologie classique et 4 en scanographie), dans chaque service, 20 sujets d’âge adulte et de morphologie moyenne devaient faire l’objet d’une dosimétrie. En radiologie classique, la dose à l’entrée a été mesurée par dosimètres thermoluminescents placés à la peau, pour 1231 patients. En scanographie l’indice de dose de scanographie pondéré et le produit dose × longueur ont été déterminés pour 667 patients à partir des paramètres de l’examen et des données de base du scanner. Pour chaque type d’examen les valeurs moyennes de chacune de ces grandeurs ainsi que celles du 75e percentile ont été calculées. Pour la grande majorité des examens et des centres ayant participé à l’étude, il apparaît que ces valeurs se situent en dessous des NRD proposés par la Commission européenne en 1996. Ces résultats, analysés en fonction des facteurs d’influence sur la dose et des limites méthodologiques de l’étude (volontariat des services participant), prouvent la faisabilité et le grand intérêt d’une campagne nationale de mesures de doses en radiologie, à plus grande échelle, qui permettrait d’établir des NRD spécifiques à la pratique française, de prévoir leur révision périodique et de définir les démarches d’optimisation appropriées.