The Querari Complex corresponds to the basement rocks from Uaupés Domain and represents one of the least studied units in the northwest of the Rio Negro Province, Amazonian Craton. In this paper, we present new field geology, petrographic, and geochemical data of deformed granites from the Querari Complex. Based on our results, we suggest the differentiation of the Querari Complex into two magmatic facies. The Panã-Panã Facies comprise mainly porphyritic syeno to monzogranites with biotite as the main mafic mineral, and titanite, epidote, and allanite as accessory phases. The rocks of the Panã-Panã Facies have calc-alkaline and metaluminous affinities. The Matapi Facies have a syenogranite composition, coarse to porphyritic texture with magmatic muscovite and biotite, normative corundum higher than 1% (1.85-2.06), and mostly a peraluminous character. Both facies are generally enriched in silica and have a small spectrum of variation. (67.5 to 70.1 wt.% Panã-Panã Facies - 71.1 to 73 wt.% Matapi Facies), but they differ by the high Al2O3, Fe2O3, MgO, CaO, Sr, and Ba contents in the Matapi Facies. Geological and geochemical compositions suggest that the magmatic precursors of these rocks of Matapi Facies may be derived from partial melting of metasedimentary sources, whereas the Panã-Panã Facies are probably derived from a meta-ignea source of intermediate composition, such as tonalitic gneisses. The rocks of the Querari Complex would have been generated in the collisional tectonic settings during the Paleoproterozoic (between 1778 and 1740 Ma). During this 1.78-1.74 Ga tectono-magmatic event (D1), the magmatic fabric (S0) and the parallel S1 foliation have been developed, with NE-SE orientation. A subsequent tectonic event (D2) was responsible for the folding S1 foliation, creating the S2 axial planar foliation with an approximate orientation E-W. This D2 event is thought to represent a Calymmian (1.52 - 1.48 Ga) tectono-metamorphic event, associated with widespread I- and S-type granite emplacement in the Rio Negro Province. The deformation textures, as well as the mineral paragenesis for the Panã-Panã and Matapi facies, reveal temperature conditions at upper amphibolite facies, up to 700ºC. Finally, the D3 tectono-metamorphic event comprises the reactivation of many NE-SW ductile shear zones with sinistral kinematic, creating a mylonitic foliation (S3) in the rocks of the Querari Complex. This D3 tectono-metamorphic event is probably linked to the intracratonic K´Mudku tectono-metamorphic event (between 1317 and 1198 Ma) of the Amazonian Greenvillian-Sunsás continental collision.