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4. Intranasal human-recombinant NGF administration improves outcome in children with post-traumatic unresponsive wakefulness syndrome

Author

Gatto, Antonio, Capossela, Lavinia, Conti, Giorgio, Eftimiadi, Gemma, Ferretti, Serena, Manni, Luigi, Curatola, Antonietta, Graglia, Benedetta, Di Sarno, Lorenzo, Calcagni, Maria Lucia, Di Giuda, Daniela, Cecere, Stefano, Romeo, Domenico Marco, Soligo, Marzia, Picconi, Enzo, Piastra, Marco, Della Marca, Giacomo, Staccioli, Susanna, Ruggiero, Antonio, Cocciolillo, Fabrizio, Pulitanò, Silvia, and Chiaretti, Antonio

Published
2023
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5. Combined treatment of nerve growth factor and transcranical direct current stimulations to improve outcome in children with vegetative state after out-of-hospital cardiac arrest

Author

Curatola, Antonietta, Graglia, Benedetta, Granata, Giuseppe, Conti, Giorgio, Capossela, Lavinia, Manni, Luigi, Ferretti, Serena, Di Giuda, Daniela, Romeo, Domenico Marco, Calcagni, Maria Lucia, Soligo, Marzia, Castelli, Enrico, Piastra, Marco, Mantelli, Flavio, Marca, Giacomo Della, Staccioli, Susanna, Romeo, Tiziana, Pani, Marcello, Cocciolillo, Fabrizio, Mancino, Aldo, Gatto, Antonio, and Chiaretti, Antonio

Published
2023
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11. Clinical characteristics of a large cohort of patients with narcolepsy candidate for pitolisant: a cross-sectional study from the Italian PASS Wakix® Cohort

Author

Mutti, Carlotta, Brunetti, Valerio, Figorilli, Michela, Liguori, Claudio, Pizza, Fabio, Proserpio, Paola, Sacco, Tommaso, Pedrazzi, Giuseppe, Lecomte, Isabelle, Blanchard, Nora, Agostoni, Elio Clemente, Bonanni, Enrica, Centonze, Diego, Cicolin, Alessandro, Della Marca, Giacomo, Ferini-Strambi, Luigi, Ferri, Raffaele, Gigli, Gian Luigi, Izzi, Francesca, Liguori, Rocco, Lodi, Raffaele, Nobili, Lino, Parrino, Liborio, Placidi, Fabio, Puligheddu, Monica, Romigi, Andrea, Savarese, Maria Antonietta, Terzaghi, Michele, and Plazzi, Giuseppe

Published
2022
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14. Movement disorders following mechanical thrombectomy resulting in ischemic lesions of the basal ganglia: An emerging clinical entity

Author

Rigon, Leonardo, Genovese, Danilo, Piano, Carla, Brunetti, Valerio, Guglielmi, Valeria, Cimmino, Angelo Tiziano, Scala, Irene, Citro, Salvatore, Bentivoglio, Anna Rita, Rollo, Eleonora, Di Iorio, Riccardo, Broccolini, Aldobrando, Morosetti, Roberta, Monforte, Mauro, Frisullo, Giovanni, Caliandro, Pietro, Pedicelli, Alessandro, Caricato, Anselmo, Masone, Giovanna, Calabresi, Paolo, Della Marca, Giacomo, Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Broccolini, Aldobrando (ORCID:0000-0001-8295-9271), Caliandro, Pietro (ORCID:0000-0002-1190-4879), Pedicelli, Alessandro (ORCID:0000-0002-2558-8838), Caricato, Anselmo (ORCID:0000-0001-5929-120X), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Marca, Giacomo Della (ORCID:0000-0001-6914-799X), Rigon, Leonardo, Genovese, Danilo, Piano, Carla, Brunetti, Valerio, Guglielmi, Valeria, Cimmino, Angelo Tiziano, Scala, Irene, Citro, Salvatore, Bentivoglio, Anna Rita, Rollo, Eleonora, Di Iorio, Riccardo, Broccolini, Aldobrando, Morosetti, Roberta, Monforte, Mauro, Frisullo, Giovanni, Caliandro, Pietro, Pedicelli, Alessandro, Caricato, Anselmo, Masone, Giovanna, Calabresi, Paolo, Della Marca, Giacomo, Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Broccolini, Aldobrando (ORCID:0000-0001-8295-9271), Caliandro, Pietro (ORCID:0000-0002-1190-4879), Pedicelli, Alessandro (ORCID:0000-0002-2558-8838), Caricato, Anselmo (ORCID:0000-0001-5929-120X), Calabresi, Paolo (ORCID:0000-0003-0326-5509), and Marca, Giacomo Della (ORCID:0000-0001-6914-799X)

Abstract

Background and purposePost-stroke movement disorders (PMDs) following ischemic lesions of the basal ganglia (BG) are a known entity, but data regarding their incidence are lacking. Ischemic strokes secondary to proximal middle cerebral artery (MCA) occlusion treated with thrombectomy represent a model of selective damage to the BG. The aim of this study was to assess the prevalence and features of movement disorders after selective BG ischemia in patients with successfully reperfused acute ischemic stroke (AIS).MethodsWe enrolled 64 consecutive subjects with AIS due to proximal MCA occlusion treated with thrombectomy. Patients were clinically evaluated by a movement disorders specialist for PMDs onset at baseline, and after 6 and 12 months.ResultsNone of the patients showed an identifiable movement disorder in the subacute phase of the stroke. At 6 and 12 months, respectively, 7/25 (28%) and 7/13 (53.8%) evaluated patients developed PMDs. The clinical spectrum of PMDs encompassed parkinsonism, dystonia and chorea, either isolated or combined. In most patients, symptoms were contralateral to the lesion, although a subset of patients presented with bilateral involvement and prominent axial signs.ConclusionPost-stroke movement disorders are not uncommon in long-term follow-up of successfully reperfused AIS. Follow-up conducted by a multidisciplinary team is strongly advisable in patients with selective lesions of the BG after AIS, even if asymptomatic at discharge.

Published
2024

15. Mechanical thrombectomy in acute ischemic stroke due to large vessel occlusion in the anterior circulation and low baseline National Institute of Health Stroke Scale score: a multicenter retrospective matched analysis

Author

Alexandre, Andrea Maria, Valente, Iacopo, Pedicelli, Alessandro, Pezzullo, Angelo Maria, Colò, Francesca, Scarcia, Luca, Romi, Andrea, Piano, Mariangela, Macera, Antonio, Gabrieli, Joseph Domenico, Cester, Giacomo, Caragliano, Antonio Armando, Vinci, Sergio Lucio, Ruggiero, Maria, Commodaro, Christian, Saletti, Andrea, Lazzarotti, Guido Andrea, Cosottini, Mirco, Da Ros, Valerio, Bellini, Luigi, Lozupone, Emilio, Paladini, Adriana, Brunetti, Valerio, Morosetti, Roberta, Frisullo, Giovanni, Calabresi, Paolo, Marca, Giacomo Della, and Broccolini, Aldobrando

Published
2022
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16. Decompressive hemicraniectomy in patients with malignant middle cerebral artery infarction: A real-world study

Author

Pilato, Fabio, Pellegrino, Giovanni, Calandrelli, Rosalinda, Broccolini, Aldobrando, Della Marca, Giacomo, Frisullo, Giovanni, Morosetti, Roberta, Profice, Paolo, Brunetti, Valerio, Capone, Fioravante, D'Apolito, Gabriella, Quinci, Vincenzo, Albanese, Alessio, Mangiola, Annunziato, Marchese, Enrico, Pompucci, Angelo, and Di Lazzaro, Vincenzo

Published
2022
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20. Exploring the emotional and behavioural profile in paediatric narcolepsy type 1: A case–control study.

Author

Simoncini Malucelli, Giorgia, Mercante, Anna, Pizza, Fabio, Brunetti, Valerio, Biscarini, Francesco, Vandi, Stefano, Mazzoni, Alice, Franceschini, Christian, Della Marca, Giacomo, Vollono, Catello, Chieffo, Daniela Pia Rosaria, and Plazzi, Giuseppe

Subjects
DROWSINESS, NARCOLEPSY, MENTAL depression, PSYCHOLOGICAL factors, CASE-control method, BODY mass index, TOTAL maximum daily load for water pollutants, YOUTH with attention-deficit hyperactivity disorder
Abstract

Summary: Narcolepsy type 1 (NT1) is a central disorder of hypersomnolence often arising in childhood and adolescence. NT1 has a significant, but poorly defined, psychological impact. We aimed to investigate the psycho‐social functioning of children and adolescents with NT1. We performed a cross‐sectional, child and parent‐reported questionnaire survey in 37 children and adolescents (6–17 years) with NT1, compared with age‐ and sex‐matched controls. Questionnaires (SSHS, ESS‐CHAD, CDI, MASC, CBCL, CRS‐R, and SNAP‐IV) evaluated various aspects of behavioural and emotional profiles, sleep habits, and daytime sleepiness. Subsequently, NT1 intra‐group analysis was performed to investigate the effect of sex (males vs females) and pharmacological treatment (treated vs non‐treated) on psychological features. The NT1 questionnaires total scores were then correlated with the clinical characteristics (age, body mass index [BMI], ESS‐CHAD score, cerebrospinal hypocretin‐1 [Hcrt‐1] levels, and diagnostic delay). Patients with NT1 showed a higher tendency to depressive symptoms, anxiety, somatisation, inattention, hyperactivity, oppositional/defiant problems, and other maladaptive behaviours compared with controls. Among NT1 patients, females showed a higher propensity to anxiety, and non‐treated patients displayed higher depressive symptoms. Psychological symptoms increased with age, BMI, and daytime sleepiness in patients with NT1, while a younger age was associated with more frequent somatisation symptoms. Lower cerebrospinal Hcrt‐1 levels correlated with poorer social competencies, daily activities, and inattention. Diagnostic delay was associated with a higher impact of depressive symptoms and behavioural problems. NT1 in children and adolescents is associated with poorer functioning in multiple psychological domains calling for a multidisciplinary approach and monitoring to reduce disease burden and to prevent psychiatric consequences. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Movement disorders following mechanical thrombectomy resulting in ischemic lesions of the basal ganglia: An emerging clinical entity

Author

Rigon, Leonardo, primary, Genovese, Danilo, additional, Piano, Carla, additional, Brunetti, Valerio, additional, Guglielmi, Valeria, additional, Cimmino, Angelo Tiziano, additional, Scala, Irene, additional, Citro, Salvatore, additional, Bentivoglio, Anna Rita, additional, Rollo, Eleonora, additional, Di Iorio, Riccardo, additional, Broccolini, Aldobrando, additional, Morosetti, Roberta, additional, Monforte, Mauro, additional, Frisullo, Giovanni, additional, Caliandro, Pietro, additional, Pedicelli, Alessandro, additional, Caricato, Anselmo, additional, Masone, Giovanna, additional, Calabresi, Paolo, additional, and Marca, Giacomo Della, additional

Published
2024
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24. Effect of the COVID-19 pandemic and the lockdown measures on the local stroke network

Author

Brunetti, Valerio, Broccolini, Aldobrando, Caliandro, Pietro, Di Iorio, Riccardo, Monforte, Mauro, Morosetti, Roberta, Piano, Carla, Pilato, Fabio, Bellavia, Simone, Marotta, Jessica, Scala, Irene, Pedicelli, Alessandro, Pennisi, Mariano Alberto, Caricato, Anselmo, Roberti, Cinzia, Altavista, Maria Concetta, Valenza, Alessandro, Distefano, Marisa, Cecconi, Emanuela, Fanella, Martina, Roncacci, Sabina, Tasillo, Miriam, Calabresi, Paolo, Frisullo, Giovanni, and Marca, Giacomo Della

Published
2021
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25. Automated Pupillometry Is Able to Discriminate Patients with Acute Stroke from Healthy Subjects: An Observational, Cross-Sectional Study.

Author

Scala, Irene, Miccoli, Massimo, Pafundi, Pia Clara, Rizzo, Pier Andrea, Vitali, Francesca, Bellavia, Simone, Giovanni, Jacopo Di, Colò, Francesca, Marca, Giacomo Della, Guglielmi, Valeria, Brunetti, Valerio, Broccolini, Aldobrando, Di Iorio, Riccardo, Monforte, Mauro, Calabresi, Paolo, and Frisullo, Giovanni

Subjects
PUPILLARY reflex, ISCHEMIC stroke, PUPILLOMETRY, STROKE patients, STROKE, INTRACRANIAL hypertension
Abstract

Background: Automated pupillometry (AP) is a handheld, non-invasive tool that is able to assess pupillary light reflex dynamics and is useful for the detection of intracranial hypertension. Limited evidence is available on acute ischemic stroke (AIS) patients. The primary objective was to evaluate the ability of AP to discriminate AIS patients from healthy subjects (HS). Secondly, we aimed to compute a predictive score for AIS diagnosis based on clinical, demographic, and AP variables. Methods: We included 200 consecutive patients admitted to a comprehensive stroke center who underwent AP assessment through NPi-200 (NeurOptics®) within 72 h of stroke onset and 200 HS. The mean values of AP parameters and the absolute differences between the AP parameters of the two eyes were considered in the analyses. Predictors of stroke diagnosis were identified through univariate and multivariate logistic regressions; we then computed a nomogram based on each variable's β coefficient. Finally, we developed a web app capable of displaying the probability of stroke diagnosis based on the predictive algorithm. Results: A high percentage of pupil constriction (CH, p < 0.001), a low constriction velocity (CV, p = 0.002), and high differences between these two parameters (p = 0.036 and p = 0.004, respectively) were independent predictors of AIS. The highest contribution in the predictive score was provided by CH, the Neurological Pupil Index, CV, and CV absolute difference, disclosing the important role of AP in the discrimination of stroke patients. Conclusions: The results of our study suggest that AP parameters, and in particular, those concerning pupillary constriction, may be useful for the early diagnosis of AIS. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Stroke-related delirium in patients undergoing revascularization treatments: A retrospective, observational study

Author

Rollo, Eleonora, primary, Monforte, Mauro, additional, Brunetti, Valerio, additional, Di Iorio, Riccardo, additional, Fulignati, Luisa, additional, De Scisciolo, Martina, additional, Silva, Serena, additional, Scavone, Angela, additional, Caricato, Anselmo, additional, Calabresi, Paolo, additional, and Marca, Giacomo Della, additional

Published
2023
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32. Association of Obstructive Sleep Apnea and Atrial Fibrillation in Acute Ischemic Stroke: A Cross-Sectional Study

Author

Brunetti, Valerio, Testani, Elisa, Losurdo, Anna, Vollono, Catello, Broccolini, Aldobrando, Di Iorio, Riccardo, Frisullo, Giovanni, Pilato, Fabio, Profice, Paolo, Marotta, Jessica, Rollo, Eleonora, Scala, Irene, Calabresi, Paolo, Della Marca, Giacomo, Broccolini, Aldobrando (ORCID:0000-0001-8295-9271), Pilato, Fabio (ORCID:0000-0002-7248-3916), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Della Marca, Giacomo (ORCID:0000-0001-6914-799X), Brunetti, Valerio, Testani, Elisa, Losurdo, Anna, Vollono, Catello, Broccolini, Aldobrando, Di Iorio, Riccardo, Frisullo, Giovanni, Pilato, Fabio, Profice, Paolo, Marotta, Jessica, Rollo, Eleonora, Scala, Irene, Calabresi, Paolo, Della Marca, Giacomo, Broccolini, Aldobrando (ORCID:0000-0001-8295-9271), Pilato, Fabio (ORCID:0000-0002-7248-3916), Calabresi, Paolo (ORCID:0000-0003-0326-5509), and Della Marca, Giacomo (ORCID:0000-0001-6914-799X)

Abstract

Background: There is a growing body of evidence suggesting a link between obstructive sleep apnea (OSA) and atrial fibrillation (AF). The primary objective of this study is to evaluate the association between OSA and AF in acute ischemic stroke. The secondary objective is to describe the clinical features of patients with acute ischemic stroke and concomitant OSA. Methods: We enrolled consecutive patients with acute ischemic stroke. All patients underwent full-night cardiorespiratory polygraphy. To determine if there is an association between AF and OSA, we compared the observed frequency of this association with the expected frequency from a random co-occurrence of the two conditions. Subsequently, patients with and without OSA were compared. Results: A total of 174 patients were enrolled (mean age 67.3 ± 11.6 years; 95 males). OSA and AF were present in 89 and 55 patients, respectively. The association OSA + AF was observed in 33/174 cases, which was not statistically different compared to the expected co-occurrence of the two conditions. Patients with OSA showed a higher neck circumference and body mass index, a higher prevalence of hypertension and dysphagia, and a higher number of central apneas/hypoapneas. In the multivariate analysis, dysphagia and hypertension were independent predictors of OSA. A positive correlation was observed between OSA severity, BMI, and neck circumference. The number of central apneas/hypoapneas was positively correlated with stroke severity. Conclusions: Our data suggest that OSA and AF are highly prevalent but not associated in acute stroke. Our findings support the hypothesis that OSA acts as an independent risk factor for stroke.

Published
2023

33. Prolonged Secondary Stroke Prevention with Edoxaban: A Long-Term Follow-Up of the SATES Study

Author

Scala, Irene, Bellavia, Simone, Rizzo, Pier Andrea, Di Giovanni, Jacopo, Monforte, Mauro, Morosetti, Roberta, Della Marca, Giacomo, Pilato, Fabio, Broccolini, Aldobrando, Profice, Paolo, Frisullo, Giovanni, Marca, Giacomo Della (ORCID:0000-0001-6914-799X), Broccolini, Aldobrando (ORCID:0000-0001-8295-9271), Scala, Irene, Bellavia, Simone, Rizzo, Pier Andrea, Di Giovanni, Jacopo, Monforte, Mauro, Morosetti, Roberta, Della Marca, Giacomo, Pilato, Fabio, Broccolini, Aldobrando, Profice, Paolo, Frisullo, Giovanni, Marca, Giacomo Della (ORCID:0000-0001-6914-799X), and Broccolini, Aldobrando (ORCID:0000-0001-8295-9271)

Abstract

Background: Little evidence is available on the long-term efficacy and safety of edoxaban, mainly due to the recent release date. The primary objective of the study was to evaluate the safety of edoxaban, defined by the incidence of major bleedings. We then aimed to evaluate the incidence of thromboembolic events and the persistence of edoxaban therapy in the long-term. Methods: In this observational cohort study, we included ischemic stroke patients enrolled in a previous study to evaluate the safety and efficacy of long-term edoxaban treatment. Data were collected by a trained investigator through a structured telephone interview. Results: Sixty-three subjects (median age 81.0 (73.5-88.0) years, 38.1% male) were included in the study, with a mean follow-up of 4.4 +/- 0.7 years (range: 3.2-5.5 years). Only one patient (1.6%, 0.4%/year) presented a major extracranial bleeding, and none had cerebral hemorrhage. Six thromboembolic events occurred in five patients (7.9%): three recurrent strokes, two transient ischemic attacks, and one myocardial infarction (2.2%/year). Over a follow-up period of more than three years, 13 patients discontinued edoxaban (20.6%). Conclusions: Edoxaban seems to be effective and safe in the long-term. The persistence rate of edoxaban therapy is optimal after more than three years of treatment.

Published
2023

34. Basal ganglia ischaemic infarction after thrombectomy: cognitive impairment at acute stage

Author

Guglielmi, Valeria, Quaranta, Davide, Masone Iacobucci, Giovanna, Citro, Salvatore, Scala, Irene, Genovese, Danilo, Brunetti, Valerio, Marra, Camillo, Calabresi, Paolo, Della Marca, Giacomo, Marra, Camillo (ORCID:0000-0003-3994-4044), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Della Marca, Giacomo (ORCID:0000-0001-6914-799X), Guglielmi, Valeria, Quaranta, Davide, Masone Iacobucci, Giovanna, Citro, Salvatore, Scala, Irene, Genovese, Danilo, Brunetti, Valerio, Marra, Camillo, Calabresi, Paolo, Della Marca, Giacomo, Marra, Camillo (ORCID:0000-0003-3994-4044), Calabresi, Paolo (ORCID:0000-0003-0326-5509), and Della Marca, Giacomo (ORCID:0000-0001-6914-799X)

Abstract

Background and purpose: After successful mechanical thrombectomy for middle cerebral artery occlusion, basal ganglia infarction is commonly detectable. Whilst the functional outcome of these patients is often good, less knowledge is available about the cognitive outcome. The aim of our study was to assess the presence of cognitive impairment within 1 week after thrombectomy.Methods: In all, 43 subjects underwent a general cognitive assessment using the Montreal Cognitive Assessment and an extensive battery of tests. Patients were classified as cognitively impaired (CImp) or not (noCImp) according to a Montreal Cognitive Assessment score below 18.Results: Cognitively impaired and noCImp subjects did not differ either in their National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) at admittance, or in their Fazekas score and Alberta Stroke Program Early Computed Tomography Score. At discharge, CImp subjects showed higher scores than noCImp subjects on NIHSS (p = 0.002) and mRS (p < 0.001). The percentage of pathological performances on each neuropsychological test in the whole sample and in CImp and noCImp patients shows a similar cognitive profile between the groups.Conclusions: Some patients who underwent thrombectomy experienced a detectable cognitive impairment that probably led to worse NIHSS and mRS. The neuropsychological profile of such cognitive impairment at the acute stage consists of wide deficits in numerous cognitive domains, suggesting that basal ganglia damage may lead to complex functional impairments.

Published
2023

38. Prevalence and predictor factors of respiratory impairment in a large cohort of patients with Myotonic Dystrophy type 1 (DM1): A retrospective, cross sectional study

Author

Rossi, Salvatore, Della Marca, Giacomo, Ricci, Martina, Perna, Alessia, Nicoletti, Tommaso F., Brunetti, Valerio, Meleo, Emiliana, Calvello, Mariarosaria, Petrucci, Antonio, Antonini, Giovanni, Bucci, Elisabetta, Licchelli, Loretta, Sancricca, Cristina, Massa, Roberto, Rastelli, Emanuele, Botta, Annalisa, Di Muzio, Antonio, Romano, Sonia, Garibaldi, Matteo, and Silvestri, Gabriella

Published
2019
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40. Exploring the emotional and behavioural profile in paediatric narcolepsy type 1: A case–control study

Author

Simoncini Malucelli, Giorgia, primary, Mercante, Anna, additional, Pizza, Fabio, additional, Brunetti, Valerio, additional, Biscarini, Francesco, additional, Vandi, Stefano, additional, Mazzoni, Alice, additional, Franceschini, Christian, additional, Della Marca, Giacomo, additional, Vollono, Catello, additional, Chieffo, Daniela Pia Rosaria, additional, and Plazzi, Giuseppe, additional

Published
2023
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41. Short- vs long-term assessment of heart rate variability: Clinical significance in Dravet Syndrome

Author

Perulli, Marco, primary, Scala, Irene, additional, Venditti, Romina, additional, Amadio, Antonio, additional, Luigia Gambardella, Maria, additional, Quintiliani, Michela, additional, Contaldo, Ilaria, additional, Veredice, Chiara, additional, Della Marca, Giacomo, additional, Brunetti, Valerio, additional, and Battaglia, Domenica Immacolata, additional

Published
2023
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