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The present article evaluates the effect of variation of WF on the tensile strength, modulus, and elongation at break. The pin-bearing properties usually correlate well with tensile properties. Tensile strength and pin-bearing strength decrease but tensile modulus increases on addition of WF. The tensile strength, pin-bearing strength, and mode of pin-bearing failure also depends on the void content. Increase in void content has a detrimental effect on all the mechanical properties. Wide variation is observed in impact strength because of unpredictable void content due to use of non-vented extrusion process. TGA indicates insignificant effect of WF on thermal stability of composites. Infrared spectroscopy indicates some interaction between PVC and WF. [ABSTRACT FROM AUTHOR]

Sonophoresis is the most approachable mode of transdermal drug delivery system, wherein low-frequency sonophoresis penetrates the drug molecules into the skin. It is an alternative method for an oral system of drug delivery and hypodermal injections. The cavitation effect is thought to be the main mechanism used in sonophoresis. The cavitation process involves forming a gaseous bubble and its rupture, induced in the coupled medium. Other mechanisms used are thermal effects, convectional effects, and mechanical effects. It mainly applies to transporting hydrophilic drugs, macromolecules, gene delivery, and vaccine delivery. It is also used in carrier-mediated delivery in the form of micelles, liposomes, and dendrimers. Some synergistic effects of sonophoresis, along with some permeation enhancers, such as chemical enhancers, iontophoresis, electroporation, and microneedles, increased the effectiveness of drug penetration. Sonophoresis-mediated ocular drug delivery, nail drug delivery, gene delivery to the brain, sports medicine, and sonothrombolysis are also widely used. In conclusion, while sonophoresis offers promising applications in diverse fields, further research is essential to comprehensively elucidate the biophysical mechanisms governing ultrasound-tissue interactions. Addressing these gaps in understanding will enable the refinement and optimization of sonophoresis-based therapeutic strategies for enhanced clinical efficacy., Competing Interests: All authors declare that they have no conflicts of interest regarding the publication of this article., (Copyright © 2024 Divya Marathe et al.)

Cyclic volatile methyl siloxanes (cVMS) have now become a subject of environmental contamination and risk assessment due to their widespread use and occurrence in different environmental matrices. Due to their exceptional physio-chemical properties, these compounds are diversely used for formulations of consumer products and others implying their continuous and significant release to environmental compartments. This has captured the major attention of the concerned communities on the grounds of potential health hazards to human and biota. The present study aims at comprehensively reviewing its occurrence in air, water, soil, sediments, sludge, dusts, biogas, biosolids, and biota and their environmental behavior as well. Concentrations of cVMS in indoor air and biosolids were higher; however, no significant concentrations were observed in water, soil, and sediments except for wastewaters. No threat to the aquatic organisms has been identified as their concentrations do not exceed the NOEC (maximum no observed effect concentration) thresholds. Mammalian (rodents) toxicity hazards were not very evident except for the occurrence of uterine tumors in very rare cases under long-term chronic and repeated dose exposures in laboratory conditions. Human relevancy to rodents were also not strongly enough established. Therefore, more careful examinations are required to develop stringent weight of evidences in scientific domain and ease the policy making with respect to their production and use so as to combat any environmental consequences., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

A seven month, pot study was conducted to evaluate the impact of moderately saline wastewater on the growth potential of six forestry plant species viz., Eucalyptus calmaldulensis, Dendrocalamus strictus , Casurina equisetfolia , Cassia fistula , Melia dubia , and Bambusa arundinacea under different drainage conditions namely, well-drained saline (WDS) condition and poor-drained saline condition (PDS) and the control with well-drained non-saline condition. WDS treatment resulted in no mortality whereas PDS treatment resulted in mortality in the range of 33-66%. The plant height and root dry biomass increased in the range of 145% to 221.6% and 4.3-37.1 g respectively in WDS treatment, however, 23.60% to 173.4% and 4.1-10.1 g in PDS treatment. Among all, Eucalyptus camaldulensis and Dendrocalamus strictus showed high Na + accumulation in roots (2.16 ± 0.02% and 1.13 ± 0.01%), shoots (1.98 ± 0.01% and 0.74 ± 0.01%) and leaves (1.27 ± 0.02% and 0.86 ± 0.01%) in WDS treatment and in case of PDS treatment root (1.01 ± 0.01% and 0.23 ± 0.01%), shoot (1.12 ± 0.02% and 0.11 ± 0.01%), and leaf (0.07 ± 0.01% and 0.1 ± 0.02). The overall performance of both Eucalyptus camaldulensis and Dendrocalamus strictus was highest in WDS treatment. Therefore, it was concluded, that both plants had better performance than other plant species, a proper drainage system defines the overall productivity and treatment efficiency.

Black soldier fly (Hermetia illucens L. [Diptera: Stratiomyidae]) has gained huge popularity in different industrial and commercial sectors because of its excellent potential to treat organic waste and high biomass production. As the industrial application of BSF is expanding at accelerated rates, there is a need to optimize its mass scale production where the organic substrates play a very crucial role in optimal growth and development. The present study deals with the investigation of different life history attributes of BSF such as larval and adult weights, survival, pupation rate, and the development time as the function of different organic substrates [fruits and vegetable mix (T1); wheat bran, soy, and corn meal mix (T2); and the dairy manure (T3)]. The larval, pupal, and adult weights differed across all three treatments (P < 0.05). There was no significant difference in the survival rate of larvae among T1 and T2 however, T3 differed significantly from T1 and T2. Likewise, the pupation rate and the development time differed significantly between the three treatments. Results indicated that the BSF development was least in dairy manure treatment and therefore, higher percent mortality and higher development time were observed. However, to deal with the problems of waste management and treatment, BSF larvae can be successfully employed for the treatment of any type of waste since it showed significant treatment efficiencies., (© The Author(s) 2021. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

The present study focuses on determining the phyto-treatment efficiency for treatment of moderately saline wastewater using organic raw materials, such as rice husk, coconut husk, rice straw, and charcoal. The moderately saline wastewater with total dissolved solids (TDS) concentration up to 6143.33 ± 5.77 mg/L was applied to the lysimeters at the rate of 200 m 3 ha -1 day -1 in five different lysimeter treatments planted with Eucalyptus camaldulensis (T1, T2, T3, T4, and T5). T1 was a control without any filter bedding material, whereas rice straw, rice husk, coconut husk, and charcoal were used as filter bedding materials in the T2, T3, T4, and T5 treatment systems, respectively. Each treatment showed significant treatment efficiency wherein T3 had the highest removal efficiency of 76.21% followed by T4 (67.57%), T5 (65.18%), T2 (46.46%), and T1 (45.5%). T3 and T4 also showed higher salt accumulation, such as sodium (Na) and potassium (K). Further, the pollution load in terms of TDS and chemical and biological oxygen demand significantly reduced from leachate in the T3 and T4 treatments in comparison with other treatments. Parameters of the soil, such as electrical conductivity, exchangeable sodium percentage, and cation exchange capacity did not show values corresponding to high salinity or sodic soils, and therefore, no adverse impact on soil was observed in the present study. Also, Eucalyptus camaldulensis plant species showed good response to wastewater treatment in terms of growth parameters, such as root/shoot weight and nitrogen, phosphorus, and potassium (NPK) uptake, plant height, biomass, and chlorophyll content. Root and shoot dry weight were in the order T3 (51.2 and 44.6 g)>T4 (49.3 and 43.5 g) > T5 (47.6 and 40.5 g) > T2 (46.9 and 38.2 g) > T1 (45.6 and 37.1 g). Likewise, the total chlorophyll content was highest in T3 (12.6 μg/g) followed by T4 (12.3 μg/g), T5 (11.9 μg/g), T2 (11.5 μg/g), and the control, that is, T1 (11.0 μg/g). However, the most promising results were obtained for T3 and T4 treatments in comparison with the control (T1), which implies that, among all organic raw materials, coconut and rice husks showed the highest potential for salt accumulation and thereby wastewater treatment. Conclusively, the findings of the study suggest that organic raw material-based amendments are useful in managing the high salts levels in both plants and leachates., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Marathe, Raghunathan, Singh, Thawale and Kumari.)

Different industrial activities such as agro-food processing and manufacturing, leather manufacturing, and paper and pulp production generate highly saline wastewater. Direct discharge of saline wastewater has resulted in pollution of waterbodies by very high magnitudes. Consequently, an enormous number of pollutants such as heavy metals, salts, and organic matter are also released into the environment threatening the survival of human and biota. Saline wastewater also has significant effects on survival of plants, agricultural activities, and groundwater systems. Several treatments and disposal technologies are available for saline wastewater, but the selection of the most appropriate treatment and disposal technology still remains a major challenge with respect to the economic or technical constraints. Considering the sustainable management of saline wastewater, the present review is an attempt to compile the existing and emerging technologies for the treatment of saline wastewater. Among all the individual and hybrid technologies, land-based treatment systems are proven to be the most efficient technologies considering the energy demands, economic, and treatment efficiencies. Likewise, new and sustainable technologies are the need of hour integrating both the treatment and management and the resource recovery factors along with the ultimate goal of the protection in terms of human health and environmental aspect. PRACTITIONER POINTS: Physico-chemical treatment technologies for saline wastewater. Combined/Hybrid technologies for the treatment of saline wastewater. Land-based treatments as the environment friendly and sustainable method for saline wastewater treatment and disposal. Role of phytoremediation in land-based treatment., (© 2021 Water Environment Federation.)

Rehabilitation of degraded lands due to mining and other activities requires rebuilding of the appropriate soil structure and microbial integrity. Organic wastes, in particular plant-based materials, play a vital role in restoration of degraded land when used as amendments for topsoil integrated with microbe-assisted phytoremediation. In this present study, a biotechnological approach using the combination of organic waste amendments, i.e., ETP (effluent treatment plant), sludge from sugarcane and paper industry, and the press mud respectively along with microbial and fungal inoculum isolated from the soil rhizosphere have been applied to study the influence on fertility and productivity of mine spoil from manganese and coal dumps. The organic amendments applied as 100-ton ha -1 and application of biofertilizers boosted the survival of plants such as Tectona grandis (Teak), Dalbergia sisso (North Indian rosewood), Phyllanthus emblica (Indian gooseberry), Gmelina arborea (Gamhar), and Acacia auriculiformis (Earpod wattle) from 80 to 100% with robust growth and development during the short span of 25 years. The physicochemical attributes of soil and the microbial count also increased significantly. The pH of mine soil dumps slightly shifted toward alkaline conditions (7.4 to 7.8) whereas bulk density, porosity, and the water holding capacity were greatly improved. Other than this, the nutrient status of mine dump soil and the plants such as available nitrogen, phosphorus, potassium and the organic carbon content in soil were improvised to a greater extent simultaneously decreasing the available manganese concentration. The findings of the study assure a better land reclamation and restoration approach., (© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

This study investigates stabilization of graphene oxide (GO) nanosheets in polyethylene oxide-polypropylene oxide (PEO-PPO) block copolymers (P103, P123 and F127). Changes in micellization of copolymers upon GO addition were monitored using dynamic light (DLS) and small angle neutron scattering (SANS). Structural developments at sheet surface were studied with two possibilities; (i) adsorption of PPO block over hydrophobic basal plane allowing the engagement of hydrophilic PEO with aqueous bulk, and (ii) adsorption of micelles mediated via carboxylated groups. Insignificant changes in micellar parameters for P123 and P127 were indicative of their inferior interaction with GO. On the other hand, P103 micelles exhibited high affinity for sheets, noticeable as emergence of mass fractals and more than two-fold enhancement in micelle number density. The latter allowed coverage of entire surface with P103 micelles. Existence of mass fractals was verified by extracting the form and structure factors from the fitted SANS data. Spectroscopic and thermogravimetric analyses illustrated non-covalent adsorption of copolymer aggregates. It was interesting to note that the dispersion remained stable against protein and electrolyte addition. A comprehensive understanding on colloidal stability can be valuable for drug delivery applications of GO sheets., Competing Interests: Declaration of competing interest Authors declare no conflict of interest., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Reliance on modeling and simulation in drug discovery and development has dramatically increased over the past decade. Two disciplines at the forefront of this activity, pharmacometrics and systems pharmacology (SP), emerged independently from different fields; consequently, a perception exists that only few examples integrate these approaches. Herein, we review the state of pharmacometrics and SP integration and describe benefits of combining these approaches in a model-informed drug discovery and development framework., (© 2018 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.)

On July 23, 2014, the FDA granted accelerated approval to idelalisib (Zydelig tablets; Gilead Sciences, Inc.) for the treatment of patients with relapsed follicular B-cell non-Hodgkin lymphoma or relapsed small lymphocytic lymphoma (SLL) who have received at least two prior systemic therapies. In a multicenter, single-arm trial, 123 patients with relapsed indolent non-Hodgkin lymphomas received idelalisib, 150 mg orally twice daily. In patients with follicular lymphoma, the overall response rate (ORR) was 54%, and the median duration of response (DOR) was not evaluable; median follow-up was 8.1 months. In patients with SLL, the ORR was 58% and the median DOR was 11.9 months. One-half of patients experienced a serious adverse reaction of pneumonia, pyrexia, sepsis, febrile neutropenia, diarrhea, or pneumonitis. Other common adverse reactions were abdominal pain, nausea, fatigue, cough, dyspnea, and rash. Common treatment-emergent laboratory abnormalities were elevations in alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, absolute lymphocytes, and triglycerides. Continued approval may be contingent upon verification of clinical benefit in confirmatory trials., (©2015 American Association for Cancer Research.)

This article summarizes the regulatory evaluation that led to the full approval of enzalutamide (XTANDI, Medivation Inc.) by the U.S. Food and Drug Administration (FDA) on August 31, 2012, for the treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel. This approval was based on the results of a randomized, placebo-controlled trial which randomly allocated 1,199 patients with mCRPC who had received prior docetaxel to receive either enzalutamide, 160 mg orally once daily (n = 800), or placebo (n = 399). All patients were required to continue androgen deprivation therapy. The primary endpoint was overall survival. At the prespecified interim analysis, a statistically significant improvement in overall survival was demonstrated for the enzalutamide arm compared with the placebo arm [HR = 0.63; 95% confidence interval: 0.53-0.75; P < 0.0001]. The median overall survival durations were 18.4 months and 13.6 months in the enzalutamide and placebo arms, respectively. The most common adverse reactions (≥10%) included asthenia or fatigue, back pain, diarrhea, arthralgia, hot flush, peripheral edema, musculoskeletal pain, headache, and upper respiratory infection. Seizures occurred in 0.9% of patients on enzalutamide compared with no patients on the placebo arm. Overall, the FDA's review and analyses of the submitted data confirmed that enzalutamide had a favorable benefit-risk profile in the study patient population, thus supporting its use for the approved indication. The recommended dose is 160 mg of enzalutamide administered orally once daily. Enzalutamide represents the third product that the FDA has approved in the same disease setting within a period of 2 years. Clin Cancer Res; 19(22); 6067-73. ©2013 AACR.

Soluble oligosaccharide mimetics of natural selectin ligands act as competitive inhibitors of leukocyte adhesion in models of inflammation. We quantified the binding of simple oligosaccharides based on sialyl Lewis-X (sLe(X)) and complex molecules with the core-2 structure to L- and P-selectin, under both static and fluid flow conditions. Isolated human neutrophils were employed to mimic the physiological valency of selectins and selectin ligands. Surface plasmon resonance studies quantified binding kinetics. We observed the following: (i) The functional group at the anomeric position of carbohydrates plays an important role during selectin recognition, since sLe(X) and sialyl Lewis-a (sLe(a)) were approximately 5-7-fold poorer inhibitors of L-selectin mediated cell adhesion compared to their methyl glycosides. (ii) Despite their homology to physiological glycans, the putative carbohydrate epitopes of GlyCAM-1 and PSGL-1 bound selectins with low affinity comparable to that of sLe(X)-selectin interactions. Thus, besides the carbohydrate portion, the protein core of GlyCAM-1 or the presentation of carbohydrates in clusters on this glycoprotein may contribute to selectin recognition. (iii) A compound Galbeta1,4(Fucalpha1,3)GlcNAcbeta1,6(GalNAcbeta1,3)GalNAcalpha-OMe was identified which blocked L- and P-selectin binding at 30-100-fold lower doses than sLe(X). (iv) Surface plasmon resonance experiments determined that an sLe(X) analogue (TBC1269) competitively inhibited, via steric/allosteric mechanisms, the binding of two anti-P-selectin function blocking antibodies that recognized different epitopes of P-selectin. (v) TBC1269 bound P-selectin via both calcium-dependent and -independent mechanisms, with K(D) of approximately 111.4 microM. The measured on- and off-rates were high (k(off) > 3 s(-)(1), k(on) > 27,000 M(-)(1) s(-)(1)). Similar binding kinetics are expected for sLe(X)-selectin interactions. Taken together, our study provides new insight into the kinetics and mechanisms of carbohydrate interaction with selectins.

Gamma-radiation-induced oxidative damage in unilamellar dipalmitoylphosphatidylcholine liposomes was investigated using a fluorescence technique. Liposomal changes in permeability induced by gamma radiation were monitored by measuring the leakage of pre-encapsulated 6-carboxyfluorescein, and alterations in lipid bilayer fluidity were determined by 1,6-diphenyl-1,3,5-hexatriene fluorescence polarization. The changes in permeability and fluidity in the bilayer were found to be dependent on the radiation dose in a biphasic fashion. The results are interpreted in terms of lipid bilayer fluidization after exposure to doses up to 1 kGy, but rigidization of the bilayer at higher doses. These results indicate a relationship between alterations in permeability and fluidity in the lipid bilayer after irradiation. The vesicles were protected significantly against radiation-induced oxidative damage in the presence of alpha-tocopherol and ascorbic acid. Radiation-induced changes in the permeability of the liposomes after exposure to gamma radiation and their modification by antioxidants indicate the involvement of a free radical mechanism in the production of damage, which may offer new insights in to the modification of cellular radiosensitivity by modulation of membrane damage.