100 results on '"Marasco SF"'
Search Results
2. Bi-National Outcomes of Redo Surgical Aortic Valve Replacement in the Era of Valve-in-Valve Transcatheter Aortic Valve.
- Author
-
Flynn CD, Tran L, Reid CM, Almeida A, and Marasco SF
- Abstract
Background: Implantation of bioprosthetic valves is more common as the population ages and there is a shift towards implanting bioprosthetic aortic valves in an increasingly younger surgical population. Bioprosthetic heart valve insertion, however, carries the long-term risk of valve failure through structural valve degeneration. Re-operative surgical aortic valve replacement has historically been the only definitive management option for patients with prosthetic valve dysfunction, however, data on the short- and long-term outcomes following re-operative surgery in Australia and New Zealand is limited., Method: Data on all patients who underwent redo aortic valve surgery, over a 20-year period (up to 2021) was obtained from the Australian and New Zealand Society of Cardiothoracic Surgery Registry., Results: A total of 1,199 patients (770 males; 64.2% and 429 females; 35.8%) were included in the overall analysis. The 30-day mortality was 6.4% with operative urgency status the most important risk factor for peri-operative mortality. The long-term survival rate of 1,145 patients was 90.5% (95% confidence interval [CI] 88.8%-92.3%), 77% (95% CI 73.9%-80.2%) and 57.2% (95% CI 55.2%-62.8%) at 1-, 5- and 10-years post-procedure, respectively, with a median survival of 12.7 years. Pre-existing chronic kidney disease was strongly associated with poorer long-term survival. For patients under 70 years of age the 1-, 5- and 10-year survival rates were 92.9% (95% CI 90.9%-95.1%), 83.6% (95% CI 80.1%-87.3%) and 73.1% (95% CI 67.4%-79.3%), respectively., Conclusions: The results from this registry study indicate that in Australia and New Zealand, a repeat surgical aortic valve replacement can result in a relatively low mortality rate, serving as a reference point for medical procedures in these regions., Competing Interests: Conflicts of Interest There are no conflicts of interest to disclose., (Crown Copyright © 2024. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
3. Surgical stabilisation of rib fractures: A meta-analysis of randomised controlled trials.
- Author
-
Sharma VJ, Summerhayes R, Wang Y, Kure C, and Marasco SF
- Subjects
- Humans, Treatment Outcome, Fracture Fixation, Internal methods, Fracture Fixation methods, Rib Fractures surgery, Randomized Controlled Trials as Topic, Respiration, Artificial, Quality of Life, Flail Chest surgery, Length of Stay statistics & numerical data
- Abstract
Introduction: Rib fixation for ventilator dependent flail chest patients has become a mainstay of management in major trauma centres. However, the expansion of rib fixation for fractured ribs beyond this remains largely in the hands of enthusiasts with the benefits in non ventilator dependent groups largely unproven. Previous meta-analyses have largely included non-randomised and retrospective data, much of which is now more than two decades out of date. We wanted to perform an updated meta-analysis including only rigorous prospective trials which were randomised. Further we wanted to include quality of life outcomes which have not been previously examined in published meta-analyses., Methods: This meta-analysis was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines and included randomised controlled trials only, of rib fixation compared to non-operative management in adult patients., Results: Eight studies comprising 752 patients of whom 372 had been randomised to receive rib fixation were included. Benefits of rib fixation were identified with significant reductions in mechanical ventilation and lengths of stay (both ICU and hospital) as well as rates of pneumonia and tracheostomy. No significant benefit in quality of life at 6 months was identified., Conclusion: Operative intervention for rib fractures leads to significantly lower rates of pneumonia, lengths of intensive care stay and time on mechanical ventilation compared to non-operative intervention. Further study is needed to investigate quality of life improvements after rib fractures as operative rib fixation expands to non-ventilator dependent groups., Competing Interests: Declaration of competing interest SM has received honorariums for lectures given by Johnson and Johnson and Zimmer Biomet. VS, RS, YW and CK declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Crown Copyright © 2024. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
4. Characteristics and Outcomes of a Single-Centre Cohort of Adult Congenital Heart Disease Patients Referred for Heart Transplant.
- Author
-
Jayadeva PS, Peters S, Tee SL, Burchill LJ, Marasco SF, Grigg L, Leet A, McGiffin D, and Zentner D
- Subjects
- Humans, Male, Female, Adult, Retrospective Studies, Follow-Up Studies, Heart Failure surgery, Survival Rate trends, Australia epidemiology, Middle Aged, Heart Defects, Congenital surgery, Heart Transplantation, Referral and Consultation, Waiting Lists
- Abstract
Background: Adult congenital heart disease (ACHD) services increasingly encounter heart failure (HF) in the ageing ACHD population. Optimal timing of referral for heart transplant (HTx) evaluation in this heterogeneous population is complex and ill-defined. We aim to outline the characteristics and outcomes of ACHD patients referred for HTx from a large Australian ACHD centre., Method: Retrospective review of ACHD patients referred for HTx from a primary ACHD centre (1992-2021). Database analysis of patient demographics, characteristics, wait-listing, and transplantation outcomes was performed., Results: A total of 45 patients (mean age 37±9.9 years old; 69% male) were referred for HTx with a mean follow-up of 5.9±6.3 years. Of these, 22 of 45 (49%) were listed and transplanted, including one heart-lung transplant. The commonest diagnosis was dextro-transposition of the great arteries (13/45, 29%). Most patients, 33 of 45 (73.3%) had undergone at least one cardiac surgery in childhood. Indications for HTx referral included HF in 34 of 45 (75%), followed by pulmonary hypertension in 7 of 45 (11%). Median transplant wait-list time was 145 days (interquartile range, 112-256). Of the 23 patients not wait-listed, the reasons included clinical stability in 13 of 45 (29%), psychosocial factors in 2 of 45 (4.4%) and prohibitive surgical risk, including multiorgan dysfunction, in 8 of 45 (17.7%). Transplant was of a single organ in most, 21 of 22 (95.5%). Overall mortality was 5 of 22 (22.7%) in those after HTx, and 14 of 23 (60.9%) in those not listed (p=0.0156)., Conclusions: Increasingly, ACHD patients demonstrate the need for advanced HF treatments. HTx decision-making is complex, and increased mortality is seen in those not wait-listed. Ultimately, the referral of ACHD patients for HTx is underpinned by local decision-making and experience, wait-list times and outcomes., Competing Interests: Conflicts of Interest There are no conflicts of interest to disclose., (Crown Copyright © 2024. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
5. Impact of postoperative hyperlactatemia in orthotopic heart transplantation.
- Author
-
Doi A, Batchelor R, Demase KC, Manfield JC, Burrell A, Paul E, Marasco SF, Kaye D, and McGiffin DC
- Subjects
- Humans, Male, Female, Retrospective Studies, Middle Aged, Adult, Extracorporeal Membrane Oxygenation, Lactic Acid blood, Length of Stay, Incidence, Respiration, Artificial, Heart Transplantation adverse effects, Hyperlactatemia etiology, Postoperative Complications etiology
- Abstract
Background: Hyperlactatemia (HL) is a common phenomenon after cardiac surgery which is related to tissue hypoperfusion and hypoxia and associated with poor outcomes. It is also often seen in the postoperative period after orthotopic heart transplantation (OHTx), but the association between HL and outcomes after OHTx is not well known. We evaluated the incidence and outcome of HL after OHTx., Methods: This was a retrospective study of 209 patients who underwent OHTx between January 2011 and December 2020. Patients were classified into 3 groups according to their peak lactate levels within the first 72 h postoperatively: group 1, normal to mild hyperlactatemia (<5 mmol/L, n = 42); group 2, moderate hyperlactatemia (5-10 mmol/L, n = 110); and group 3, severe hyperlactatemia (>10 mmol/L, n = 57). The primary composite endpoint was all-cause mortality or postoperative initiation of veno-arterial extracorporeal membrane oxygenation (VA ECMO) within 30 days. Secondary endpoints included duration of mechanical ventilation, intensive care unit length of stay, and hospital length of stay., Results: Patients with higher postoperative peak lactate levels were more commonly transplanted from left ventricular assist device support (33.3 % vs 50.9 % vs 64.9, p < 0.01) and had longer cardiopulmonary bypass time [127 min (109-148) vs 141 min (116-186) vs 153 min (127-182), p = 0.02]. Composite primary endpoint was met in 18 patients (8.6 %) and was significantly more common in patients with higher postoperative peak lactate levels (0.0 % vs 6.4 % vs 19.3 %, p < 0.01)., Conclusions: Severe hyperlactatemia following orthotopic heart transplant was associated with an increased risk of post-transplant VA ECMO initiation and mortality at 30 days., Competing Interests: Declaration of competing interest The authors declare no conflicts of interest., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
6. 2023 Cardiac Society of Australia and New Zealand Expert Position Statement on Catheter and Surgical Ablation for Atrial Fibrillation.
- Author
-
Kistler PM, Sanders P, Amarena JV, Bain CR, Chia KM, Choo WK, Eslick AT, Hall T, Hopper IK, Kotschet E, Lim HS, Ling LH, Mahajan R, Marasco SF, McGuire MA, McLellan AJ, Pathak RK, Phillips KP, Prabhu S, Stiles MK, Sy RW, Thomas SP, Toy T, Watts TW, Weerasooriya R, Wilsmore BR, Wilson L, and Kalman JM
- Subjects
- Humans, Australia, Cardiology standards, New Zealand, Societies, Medical, Atrial Fibrillation surgery, Catheter Ablation methods, Catheter Ablation standards
- Abstract
Catheter ablation for atrial fibrillation (AF) has increased exponentially in many developed countries, including Australia and New Zealand. This Expert Position Statement on Catheter and Surgical Ablation for Atrial Fibrillation from the Cardiac Society of Australia and New Zealand (CSANZ) recognises healthcare factors, expertise and expenditure relevant to the Australian and New Zealand healthcare environments including considerations of potential implications for First Nations Peoples. The statement is cognisant of international advice but tailored to local conditions and populations, and is intended to be used by electrophysiologists, cardiologists and general physicians across all disciplines caring for patients with AF. They are also intended to provide guidance to healthcare facilities seeking to establish or maintain catheter ablation for AF., (Copyright © 2024 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
7. HeartMate 3 implantation with an emphasis on the biventricular configuration.
- Author
-
Marasco SF, McLean J, Kure CE, Rix J, Lake T, Linton A, Farag J, Zhu MZL, Doi A, Bergin PJ, Leet AS, Taylor AJ, Hare JL, Patel HC, Kaye D, and McGiffin DC
- Subjects
- Humans, Middle Aged, Male, Female, Adult, Retrospective Studies, Treatment Outcome, Heart Transplantation methods, Australia epidemiology, Prosthesis Implantation instrumentation, Prosthesis Implantation adverse effects, Prosthesis Implantation methods, Heart-Assist Devices, Heart Failure surgery, Heart Failure mortality, Heart Failure therapy
- Abstract
Objectives: Right ventricular failure following implantation of a durable left ventricular assist device (LVAD) is a major driver of mortality. Reported survival following biventricular (BiVAD) or total artificial heart (TAH) implantation remains substantially inferior to LVAD alone. We report our outcomes with LVAD and BiVAD HeartMate 3 (HM3)., Methods: Consecutive patients undergoing implantation of an HM3 LVAD between November 2014 and December 2021, at The Alfred, Australia were included in the study. Comparison was made between the BiVAD and LVAD alone groups., Results: A total of 86 patients, 65 patients with LVAD alone and 21 in a BiVAD configuration underwent implantation. The median age of the LVAD and BiVAD groups was 56 years (Interquartile range 46-62) and 49 years (Interquartile range 37-55), respectively. By 4 years after implantation, 54% of LVAD patients and 43% of BiVAD patients had undergone cardiac transplantation. The incidence of stroke in the entire experience was 3.5% and pump thrombosis 5% (all in the RVAD). There were 14 deaths in the LVAD group and 1 in the BiVAD group. The actuarial survival for LVAD patients at 1 year was 85% and BiVAD patients at 1 year was 95%., Conclusions: The application of HM 3 BiVAD support in selected patients appears to offer a satisfactory solution to patients requiring biventricular support., (© 2024 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.)
- Published
- 2024
- Full Text
- View/download PDF
8. Acute Kidney Injury after Heart Transplantation: Risk Stratification is Good; Risk Modification is Better-But can we do it?
- Author
-
Zhu MZL, Marasco SF, Evans RG, Kaye DM, and McGiffin DC
- Published
- 2024
- Full Text
- View/download PDF
9. Hypothermic oxygenated perfusion (HOPE) safely and effectively extends acceptable donor heart preservation times: Results of the Australian and New Zealand trial.
- Author
-
McGiffin DC, Kure CE, Macdonald PS, Jansz PC, Emmanuel S, Marasco SF, Doi A, Merry C, Larbalestier R, Shah A, Geldenhuys A, Sibal AK, Wasywich CA, Mathew J, Paul E, Cheshire C, Leet A, Hare JL, Graham S, Fraser JF, and Kaye DM
- Subjects
- Humans, Australia epidemiology, Graft Survival, New Zealand, Organ Preservation methods, Perfusion methods, Heart Transplantation, Tissue Donors
- Abstract
Background: Cold static storage preservation of donor hearts for periods longer than 4 hours increases the risk of primary graft dysfunction (PGD). The aim of the study was to determine if hypothermic oxygenated perfusion (HOPE) could safely prolong the preservation time of donor hearts., Methods: We conducted a nonrandomized, single arm, multicenter investigation of the effect of HOPE using the XVIVO Heart Preservation System on donor hearts with a projected preservation time of 6 to 8 hours on 30-day recipient survival and allograft function post-transplant. Each center completed 1 or 2 short preservation time followed by long preservation time cases. PGD was classified as occurring in the first 24 hours after transplantation or secondary graft dysfunction (SGD) occurring at any time with a clearly defined cause. Trial survival was compared with a comparator group based on data from the International Society of Heart and Lung Transplantation (ISHLT) Registry., Results: We performed heart transplants using 7 short and 29 long preservation time donor hearts placed on the HOPE system. The mean preservation time for the long preservation time cases was 414 minutes, the longest being 8 hours and 47 minutes. There was 100% survival at 30 days. One long preservation time recipient developed PGD, and 1 developed SGD. One short preservation time patient developed SGD. Thirty day survival was superior to the ISHLT comparator group despite substantially longer preservation times in the trial patients., Conclusions: HOPE provides effective preservation out to preservation times of nearly 9 hours allowing retrieval from remote geographic locations., (Copyright © 2024 International Society for the Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
10. Use of Sutureless Valve in Aortic Root Enlargement.
- Author
-
Marasco SF, Banham T, Gregory SD, Vu T, and Stephens AF
- Subjects
- Humans, Female, Aorta, Thoracic surgery, Aortic Valve diagnostic imaging, Aortic Valve surgery, Prosthesis Design, Treatment Outcome, Heart Valve Prosthesis Implantation methods, Bioprosthesis, Heart Valve Prosthesis, Aortic Valve Stenosis diagnosis, Aortic Valve Stenosis surgery
- Abstract
Aim: The small aortic annulus is a surgical challenge in patients undergoing aortic valve replacement which may lead to patient prosthesis mismatch. Management options include aortic root enlargement, aortic root replacement, and the use of sutureless valves. In this case series, we report our results with aortic root enlargement, sutureless valve implantation, and benchtop modelling of the radial forces exerted., Methods: Five patients underwent aortic root enlargement and insertion of the Perceval valve as part of the management strategy to enlarge their effective orifice area. We further investigate this strategy with a benchtop model to quantify the radial forces exerted by the Perceval valve on the aortic annulus. Radial and hoop forces on the aortic annulus and inner ring of the Perceval valve were recorded using a Mylar force tester., Results: Five female patients with native annulus between 18mm-20mm underwent root enlargement and insertion of a Perceval S valve. The postoperative course was uncomplicated for all patients except for one who required a permanent pacemaker insertion. Transvalvular pressure gradients remained low at up to 4 years of follow-up (12 mmHg-21 mmHg), with no evidence of paravalvular leak. Benchtop testing demonstrated radial forces exerted at the annulus in all-size Perceval S valves to be within physiological variables, whereas compressive forces required to deform the valves were supraphysiological., Conclusions: The deployment of a sutureless valve within a surgical enlarged aortic root is a feasible solution in patients with a small aortic root., Competing Interests: Conflicts of Interest There are no conflicts of interest to disclose., (Crown Copyright © 2023. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
11. Is enthusiasm for rib fixation outstripping the evidence?
- Author
-
Marasco SF
- Subjects
- Humans, Ribs surgery, Fracture Fixation, Internal, Retrospective Studies, Flail Chest surgery, Rib Fractures surgery
- Abstract
Competing Interests: Declaration of Competing Interest The author declares receiving honorariums for lectures given by Johnson & Johnson and Zimmer Biomet.
- Published
- 2023
- Full Text
- View/download PDF
12. Disclosing all complications of lung transplantation on ECMO.
- Author
-
Savage N, Wayne S, Doi A, Gooi J, Zimmet A, Merry C, and Marasco SF
- Subjects
- Humans, Treatment Outcome, Retrospective Studies, Extracorporeal Membrane Oxygenation, Lung Transplantation adverse effects
- Abstract
Competing Interests: Disclosure statement The authors have no financial conflicts of interest to disclose.
- Published
- 2023
- Full Text
- View/download PDF
13. Flail chest injury-changing management and outcomes.
- Author
-
Marasco SF, Nguyen Khuong J, Fitzgerald M, Summerhayes R, Sekandarzad MW, Varley V, Campbell RJ, and Bailey M
- Subjects
- Humans, Male, Adult, Middle Aged, Aged, Female, Hospitalization, Respiration, Artificial methods, Retrospective Studies, Length of Stay, Fracture Fixation, Internal methods, Flail Chest surgery, Rib Fractures, Thoracic Injuries surgery
- Abstract
Purpose: The purpose of this study was to assess trends in management of flail chest injuries over time and to determine impact on patient outcomes., Methods: A retrospective review of data from a prospectively collated database of all trauma patients admitted to a level 1 trauma service in Victoria was conducted. All trauma patients admitted to the hospital between July 2008 and June 2020 with an Abbreviated Injury Scale (AIS) code for flail chest injury were included., Results: Our study included 720 patients, mean age was 59.5 ± 17.3 years old, and 76.5% of patients were male. Length of ICU stay decreased on average by 9 h each year. Regional anaesthesia use increased by 15% per year (0% in 2009 to 36% in 2020) (p < 0.001). Surgical stabilisation of rib fractures increased by 16% per year (2.9% in 2009 to 22.3% in 2020) (p = 0.006). The use of invasive ventilation decreased by 14% per year (70% in 2008 to 27% in 2020) (p < 0.001), and invasive ventilation time decreased by 8 h per year (p = 0.007)., Conclusion: Over the past decade, we have seen increasing rates of regional anaesthesia and surgical rib fixation in the management of flail chest. This has resulted in lower requirements for and duration of invasive mechanical ventilation and intensive care unit stay but has not impacted mortality in this patient cohort., (© 2022. Crown.)
- Published
- 2023
- Full Text
- View/download PDF
14. Extracorporeal Membrane Oxygenation for Graft Dysfunction Early After Heart Transplantation: A Systematic Review and Meta-analysis.
- Author
-
Aleksova N, Buchan TA, Foroutan F, Zhu A, Conte S, Macdonald P, Noly PE, Carrier M, Marasco SF, Takeda K, Pozzi M, Baudry G, Atik FA, Lehmann S, Jawad K, Hickey GW, Defontaine A, Baron O, Loforte A, Cavalli GG, Absi DO, Kawabori M, Mastroianni MA, Simonenko M, Sponga S, Moayedi Y, Orchanian-Cheff A, Ross HJ, Rao V, Guyatt G, Billia F, and Alba AC
- Subjects
- Adult, Humans, Hospital Mortality, Patient Discharge, Retrospective Studies, Extracorporeal Membrane Oxygenation methods, Heart Failure, Heart Transplantation adverse effects
- Abstract
Introduction: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a prevailing option for the management of severe early graft dysfunction. This systematic review and individual patient data (IPD) meta-analysis aims to evaluate (1) mortality, (2) rates of major complications, (3) prognostic factors, and (4) the effect of different VA-ECMO strategies on outcomes in adult heart transplant (HT) recipients supported with VA-ECMO., Methods and Results: We conducted a systematic search and included studies of adults (≥18 years) who received VA-ECMO during their index hospitalization after HT and reported on mortality at any timepoint. We pooled data using random effects models. To identify prognostic factors, we analysed IPD using mixed effects logistic regression. We assessed the certainty in the evidence using the GRADE framework. We included 49 observational studies of 1477 patients who received VA-ECMO after HT, of which 15 studies provided IPD for 448 patients. There were no differences in mortality estimates between IPD and non-IPD studies. The short-term (30-day/in-hospital) mortality estimate was 33% (moderate certainty, 95% confidence interval [CI] 28%-39%) and 1-year mortality estimate 50% (moderate certainty, 95% CI 43%-57%). Recipient age (odds ratio 1.02, 95% CI 1.01-1.04) and prior sternotomy (OR 1.57, 95% CI 0.99-2.49) are associated with increased short-term mortality. There is low certainty evidence that early intraoperative cannulation and peripheral cannulation reduce the risk of short-term death., Conclusions: One-third of patients who receive VA-ECMO for early graft dysfunction do not survive 30 days or to hospital discharge, and one-half do not survive to 1 year after HT. Improving outcomes will require ongoing research focused on optimizing VA-ECMO strategies and care in the first year after HT., Competing Interests: Conflict of Interest The authors report no conflicts of interest., (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
15. Heart-Lung Transplantation: Technical Modifications to Simplify the Procedure.
- Author
-
Doi A, Marasco SF, Negri JC, Gooi JH, Zimmet A, and McGiffin DC
- Subjects
- Humans, Mediastinum, Phrenic Nerve surgery, Hemorrhage, Heart-Lung Transplantation methods, Lung Transplantation
- Abstract
Heart-lung transplantation is a mature therapy but has perioperative complications, such as phrenic nerve dysfunction and mediastinal bleeding. We report our technical modifications to simplify the procedure., (Copyright © 2023 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
16. Extracorporeal Membrane Oxygenation as a Bridge to Surgical Repair of Postinfarct Ventricular Septal Defect.
- Author
-
Doi A, Negri JC, Marasco SF, Gooi JH, Zimmet A, Pellegrino VA, Nanjayya VB, McGloughlin SA, and McGiffin DC
- Subjects
- Humans, Shock, Cardiogenic etiology, Shock, Cardiogenic surgery, Retrospective Studies, Death, Extracorporeal Membrane Oxygenation methods, Heart Septal Defects, Ventricular surgery
- Abstract
Postinfarct ventricular septal defect (PIVSD) is associated with high mortality and the management of these patients has been a challenge with little improvement in outcomes. We commenced a protocol of veno-arterial extracorporeal membrane oxygenation (VA ECMO) for those patients who present in cardiogenic shock with the aim to improve end-organ function before definitive surgical repair to reduce postoperative mortality. This study reviewed the results of this strategy. This was a single-center, retrospective review of all patients who were admitted to our institution with PIVSD in cardiogenic shock from September 2015 to November 2019. Clinical and investigative data were evaluated. Eight patients were referred with PIVSD during this period in cardiogenic shock. One patient had an anterior PIVSD and the other seven had inferior PIVSD. Six patients underwent surgical repair at a median (interquartile range, IQR) of 7 (5-8) days after initiation of VA ECMO. Two patients did not undergo surgical repair. Five patients survived after surgery and one patient died postoperatively due to multiorgan failure. Preoperative use of VA ECMO is a feasible strategy for PIVSD and may improve the results of repair., Competing Interests: Disclosure: The authors have no conflicts of interest to report., (Copyright © ASAIO 2022.)
- Published
- 2023
- Full Text
- View/download PDF
17. Surgical stabilization of rib fractures versus nonoperative treatment in patients with multiple rib fractures following cardiopulmonary resuscitation: An international, retrospective matched case-control study.
- Author
-
Prins JTH, Van Lieshout EMM, Eriksson EA, Barnes M, Blokhuis TJ, Caragounis EC, Christie DB 3rd, De Loos ER, DeVoe WB, Formijne Jonkers HA, Kiel B, Ko HJ, Marasco SF, Spanjersberg WR, Su YH, Summerhayes RG, Van Huijstee PJ, Vermeulen J, Vos DI, Verhofstad MHJ, and Wijffels MME
- Subjects
- Humans, Retrospective Studies, Case-Control Studies, Treatment Outcome, Length of Stay, Rib Fractures complications, Rib Fractures surgery, Spinal Fractures complications
- Abstract
Background: The presence of six or more rib fractures or a displaced rib fracture due to cardiopulmonary resuscitation (CPR) has been associated with longer hospital and intensive care unit (ICU) length of stay (LOS). Evidence on the effect of surgical stabilization of rib fractures (SSRF) following CPR is limited. This study aimed to evaluate outcomes after SSRF versus nonoperative management in patients with multiple rib fractures after CPR., Methods: An international, retrospective study was performed in patients who underwent SSRF or nonoperative management for multiple rib fractures following CPR between January 1, 2012, and July 31, 2020. Patients who underwent SSRF were matched to nonoperative controls by cardiac arrest location and cause, rib fracture pattern, and age. The primary outcome was ICU LOS., Results: Thirty-nine operatively treated patient were matched to 66 nonoperatively managed controls with comparable CPR-related characteristics. Patients who underwent SSRF more often had displaced rib fractures (n = 28 [72%] vs. n = 31 [47%]; p = 0.015) and a higher median number of displaced ribs (2 [P 25 -P 75 , 0-3] vs. 0 [P 25 -P 75 , 0-3]; p = 0.014). Surgical stabilization of rib fractures was performed at a median of 5 days (P 25 -P 75 , 3-8 days) after CPR. In the nonoperative group, a rib fixation specialist was consulted in 14 patients (21%). The ICU LOS was longer in the SSRF group (13 days [P 25 -P 75 , 9-23 days] vs. 9 days [P 25 -P 75 , 5-15 days]; p = 0.004). Mechanical ventilator-free days, hospital LOS, thoracic complications, and mortality were similar., Conclusion: Despite matching, those who underwent SSRF over nonoperative management for multiple rib fractures following CPR had more severe consequential chest wall injury and a longer ICU LOS. A benefit of SSRF on in-hospital outcomes could not be demonstrated. A low consultation rate for rib fixation in the nonoperative group indicates that the consideration to perform SSRF in this population might be associated with other nonradiographic or injury-related variables., Level of Evidence: Therapeutic/Care Management; Level III., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
18. Surgical stabilization versus nonoperative treatment for flail and non-flail rib fracture patterns in patients with traumatic brain injury.
- Author
-
Prins JTH, Van Lieshout EMM, Ali-Osman F, Bauman ZM, Caragounis EC, Choi J, Christie DB 3rd, Cole PA, DeVoe WB, Doben AR, Eriksson EA, Forrester JD, Fraser DR, Gontarz B, Hardman C, Hyatt DG, Kaye AJ, Ko HJ, Leasia KN, Leon S, Marasco SF, McNickle AG, Nowack T, Ogunleye TD, Priya P, Richman AP, Schlanser V, Semon GR, Su YH, Verhofstad MHJ, Whitis J, Pieracci FM, and Wijffels MME
- Subjects
- Fracture Fixation, Internal, Humans, Length of Stay, Retrospective Studies, Brain Injuries, Traumatic complications, Brain Injuries, Traumatic therapy, Flail Chest surgery, Pneumonia, Rib Fractures complications
- Abstract
Purpose: Literature on outcomes after SSRF, stratified for rib fracture pattern is scarce in patients with moderate to severe traumatic brain injury (TBI; Glasgow Coma Scale ≤ 12). We hypothesized that SSRF is associated with improved outcomes as compared to nonoperative management without hampering neurological recovery in these patients., Methods: A post hoc subgroup analysis of the multicenter, retrospective CWIS-TBI study was performed in patients with TBI and stratified by having sustained a non-flail fracture pattern or flail chest between January 1, 2012 and July 31, 2019. The primary outcome was mechanical ventilation-free days and secondary outcomes were in-hospital outcomes. In multivariable analysis, outcomes were assessed, stratified for rib fracture pattern., Results: In total, 449 patients were analyzed. In patients with a non-flail fracture pattern, 25 of 228 (11.0%) underwent SSRF and in patients with a flail chest, 86 of 221 (38.9%). In multivariable analysis, ventilator-free days were similar in both treatment groups. For patients with a non-flail fracture pattern, the odds of pneumonia were significantly lower after SSRF (odds ratio 0.29; 95% CI 0.11-0.77; p = 0.013). In patients with a flail chest, the ICU LOS was significantly shorter in the SSRF group (beta, - 2.96 days; 95% CI - 5.70 to - 0.23; p = 0.034)., Conclusion: In patients with TBI and a non-flail fracture pattern, SSRF was associated with a reduced pneumonia risk. In patients with TBI and a flail chest, a shorter ICU LOS was observed in the SSRF group. In both groups, SSRF was safe and did not hamper neurological recovery., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
19. Rib fixation in non-ventilator-dependent chest wall injuries: A prospective randomized trial.
- Author
-
Marasco SF, Balogh ZJ, Wullschleger ME, Hsu J, Patel B, Fitzgerald M, Martin K, Summerhayes R, and Bailey M
- Subjects
- Fracture Fixation, Internal, Humans, Pain, Prospective Studies, Quality of Life, Ribs surgery, Flail Chest etiology, Flail Chest surgery, Rib Fractures complications, Rib Fractures surgery, Thoracic Injuries complications, Thoracic Injuries surgery, Thoracic Wall surgery
- Abstract
Background: The aim of this study was to assess pain and quality of life (QoL) outcomes in patients with multiple painful displaced fractured ribs with and without operative fixation. Rib fractures are common and can lead to significant pain and disability. There is minimal level 1 evidence for rib fixation in non-ventilator-dependent patients with chest wall injuries. We hypothesized that surgical stabilization of rib fractures would reduce pain and improve QoL during 6 months., Methods: A prospective multicenter randomized controlled trial comparing rib fixation to nonoperative management of nonventilated patients with at least three consecutive rib fractures was conducted. Inclusion criteria were rib fracture displacement and/or ongoing pain. Pain (McGill Pain Questionnaire) and QoL (Short Form 12) at 3 and 6 months postinjury were assessed. Surgeons enrolled patients in whom they felt there was clinical equipoise. Patients who were deemed to need surgical fixation or who were deemed to be too well to be randomized to rib fixation were not enrolled., Results: A total of 124 patients were enrolled at four sites between 2017 and 2020. Sixty-one patients were randomized to operative management and 63 to nonoperative management. No differences were seen in the primary endpoint of Pain Rating Index at 3 months or in the QoL measures. Return-to-work rates improved between 3 and 6 months, favoring the operative group., Conclusion: In this study, no improvements in pain or QoL at 3 and 6 months in patients undergoing rib fixation for nonflail, non-ventilator-dependent rib fractures have been demonstrated., Level of Evidence: Therapeutic/Care Management; Level II., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
20. Intra-aortic Balloon Pump Use With Extra Corporeal Membrane Oxygenation-A Mock Circulation Loop Study.
- Author
-
Farag J, Stephens AF, Juene Chong W, Gregory SD, and Marasco SF
- Subjects
- Hemodynamics, Humans, Intra-Aortic Balloon Pumping, Shock, Cardiogenic surgery, Extracorporeal Membrane Oxygenation, Heart Failure surgery, Heart-Assist Devices
- Abstract
Venoarterial extracorporeal membrane oxygenation (ECMO) is used in cardiogenic shock refractory to inotropic support and intra-aortic balloon pump (IABP) support. Peripheral ECMO can lead to ventricular distention, and IABP can be used to mitigate these effects. The aim of this study was to quantify the effects of IABP concomitant with ECMO, under different simulated hemodynamic conditions in a mock circulatory loop. Different simulated states of isolated left ventricular (LV) failure and biventricular failure with graded LV failure severities were supported with ECMO and ECMO with IABP. The impact on left ventricular end-diastolic pressure (LVEDP), volume (LVEDV), coronary flow rate, and cerebral flow rate were evaluated. Left ventricular volumes and pressures increased from the heart failure states with the addition of ECMO. The IABP provided between 3% and 7% reductions in LVEDP and between 1% and 10% reductions in LVEDV. The addition of IABP had minimal effect on cerebral blood flow (0% to 7%), but the variable impact on coronary blood flow with increased diastolic coronary flow of 23% to 50%, but the reduction in mean coronary flow by up to 30%. The efficacy of the IABP was strongly related to ventricular contractility. This study demonstrates the need for careful IABP selection concomitant with ECMO., Competing Interests: Disclosure: The authors have no conflicts of interest to report., (Copyright © ASAIO 2021.)
- Published
- 2022
- Full Text
- View/download PDF
21. Mitral Valve Regurgitation After Lung Transplantation: Aetiology, Management and Outcome.
- Author
-
Shi WY, Bloom JE, Shen R, Levvey BJ, Walton AS, Marasco SF, Zimmet A, Snell G, and McGiffin DC
- Subjects
- Humans, Mitral Valve surgery, Retrospective Studies, Treatment Outcome, Lung Transplantation adverse effects, Mitral Valve Insufficiency diagnosis, Mitral Valve Insufficiency etiology, Mitral Valve Insufficiency surgery
- Abstract
Background: Problematic mitral regurgitation (MR) may develop following lung transplantation (LTx). There is limited information on the management of MR in LTx patients, as such we sought to evaluate our centre's experience., Methods: From 2000 to 2019, 1,054 patients underwent LTx at our centre (896 bilateral, 158 single). We identified patients in whom significant MR developed at any point post-LTx. The aetiology of MR, management and outcome were retrospectively analysed., Results: Eight (8) patients developed severe MR post-LTx, six following bilateral LTx and two following single LTx. Lung transplantation indications included interstitial lung disease (n=5), chronic obstructive pulmonary disease (n=2) and pulmonary arterial hypertension (n=1). Severe MR occurred intraoperatively (n=1), postoperative day 1 (n=1) with the remaining six cases between 80 and 263 days post-LTx. The aetiology was noted to be due to severe left ventricular dysfunction following unmasking of a chronically pulmonary hypertension-related under-preloaded left ventricle in one case, and in the remaining seven patients causes included myxomatous degeneration, ischaemic MR, and functional MR due to annular dilatation. In the patient with intraoperative severe MR, the MR became mild with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and in the remaining seven patients a variety of procedures were used, including mitral valve repair, valve replacement and transcatheter edge-to-edge mitral valve repair. All patients survived the mitral procedure. Two (2) deaths occurred at 12.9 years (stroke) and 5 years (cancer) from mitral valve surgery., Conclusions: Development of significant mitral valve regurgitation is a rare but morbid complication after lung transplantation. This may represent the progressive natural history of pre-existing degenerative mitral valve disease and rarely, early after transplantation may be related to changes in ventricular geometry. Management of severe MR can follow the same management approach as in the non-transplant community, with the expectation of similarly good results., (Copyright © 2021 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
22. Unexpected suicide left ventricle post-surgical aortic valve replacement requiring veno-arterial extracorporeal membrane oxygenation support despite gold-standard therapy: a case report.
- Author
-
Lioufas PA, Kelly DN, Brooks KS, and Marasco SF
- Abstract
Background: Suicide left ventricle is a well-documented phenomenon occurring after valve replacement, however, it is most commonly described in the mitral valve replacement (MVR) and transcatheter aortic valve replacement (TAVR) population. Cases within the surgical aortic valve replacement (SAVR) population usually resolve with optimal medical and interventional therapies. We describe a case of left ventricular suicide following SAVR presenting with persistent haemodynamic instability despite currently accepted medical and surgical therapies., Case Summary: A 62-year-old male with severe aortic stenosis presented for SAVR and a MAZE procedure. There were no significant signs of ventricular hypertrophy on preoperative transthoracic echocardiogram (TTE). Intraoperatively, there was mild chordal systolic anterior motion of the mitral valve (SAM) which only occurred when underfilled. During recovery in the intensive care unit, the patient's pulmonary arterial pressures were noted to rise with worsening cardiac output. Subsequent TTE showed severe dynamic left ventricular outflow tract (LVOT) obstruction secondary to SAM. Due to refractory medical management, an alcohol septal ablation was performed. Despite resolution of obstruction, the patient exhibited biochemical signs of systemic hypoperfusion, and thus veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support was initiated. Following 72 h of VA-ECMO support, the patient was weaned with complete resolution of biochemical insults. He was subsequently discharged from the hospital without complication., Discussion: Compared to the TAVR population, suicide ventricle post-SAVR is comparatively rare. Patients who exhibit persistent impaired cardiac output postoperatively should be investigated rapidly with echocardiography. Furthermore, resolution of a LVOT obstruction state from procedural intervention may not immediately follow with improved cardiac output, and may require further supportive management., (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.)
- Published
- 2022
- Full Text
- View/download PDF
23. Spinal cord infarction and peripheral extracorporeal membrane oxygenation: a case series.
- Author
-
Gangahanumaiah S, Zhu M, Summerhayes R, and Marasco SF
- Abstract
Background: Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is increasingly utilized in patients with cardiogenic shock due to improved technology and outcomes. Peripheral VA ECMO offers several advantages over central ECMO and is becoming increasingly popular. However, when configured via the femoral vessels, retrograde flow to the descending aorta and arch of aorta competes with antegrade ventricular output and can be associated with a watershed phenomenon and increased risk of neurologic and visceral injury., Case Summary: In this case series, we report three patients who were supported with peripheral VA ECMO for cardiogenic shock. All three were successfully weaned from peripheral VA ECMO; however, they had developed bilateral lower limb paralysis. Magnetic resonance imaging revealed spinal cord infarction in all three patients. All patients subsequently succumbed to multiorgan failure and did not survive to hospital discharge., Discussion: The use of mechanical circulatory support, in particular, peripheral ECMO, has escalated with advances in technology, better understanding of cardiac physiology and improving outcomes. Spinal cord infarction is a rare but serious complication of peripheral VA ECMO support with only a few case reports published. Further studies are needed to identify the exact cause and prevention of this rare but often terminal complication. Through this series of three patients supported on peripheral VA ECMO complicated by spinal cord infarction, we review previously published reports, analyse possible mechanisms, and propose alternate management strategies to be considered in patients at risk., (© The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.)
- Published
- 2021
- Full Text
- View/download PDF
24. Comparison of Circulatory Unloading Techniques for Venoarterial Extracorporeal Membrane Oxygenation.
- Author
-
Stephens AF, Wanigasekara D, Pellegrino VA, Burrell AJC, Marasco SF, Kaye DM, Steinseifer U, and Gregory SD
- Subjects
- Heart Failure physiopathology, Heart Failure therapy, Heart-Assist Devices, Hemodynamics, Humans, Intra-Aortic Balloon Pumping, Extracorporeal Membrane Oxygenation methods
- Abstract
Left ventricular (LV) distention and pulmonary congestion are major complications inherent to venoarterial extracorporeal membrane oxygenation (ECMO). This study aimed to quantitatively compare the hemodynamic differences between common circulatory unloading methods for ECMO. Ten circulatory unloading techniques were evaluated on a mock circulatory loop simulating acute LV failure supported by ECMO. Simulated unloading techniques included: surgical and percutaneous pulmonary artery (PA) venting, surgical left atrial venting, surgical and percutaneous LV venting, atrial septal defect, partial support ventricular assist device, intraaortic balloon pump, and temporary VAD with inline oxygenator (tVAD). The most LV unloading occurred with the surgically placed LV vent and tVAD, which reduced LV end-diastolic volume from 295 to 167 ml and 82 ml, respectively. Meanwhile, the PA surgical vent was the most effective at reducing mean PA pressure from 21.0 to 10.6 mm Hg, and the tVAD was most effective at reducing left atrial pressure from 13.3 to 4.4 mm Hg. The major limitation of this study was the use of a mock circulatory loop, which simulated lower left atrial pressure than is typically seen clinically. This study identified clinically significant hemodynamic variability between the different circulatory unloading techniques evaluated. However, the applicability of these techniques will vary with different patient disease etiology. Further studies on ECMO unloading will help to quantify hemodynamic benefits and establish treatment guidelines., Competing Interests: Disclosure: The authors have no conflicts of interest to report., (Copyright © ASAIO 2020.)
- Published
- 2021
- Full Text
- View/download PDF
25. Contemporary outcomes of continuous-flow biventricular assist devices.
- Author
-
Farag J, Woldendorp K, McNamara N, Bannon PG, Marasco SF, Loforte A, and Potapov EV
- Abstract
Background: Significant right ventricular failure (RVF) complicating left ventricular assist device (LVAD) placement has been reported at 10-30%. Although primarily indicated for left ventricular failure, ventricular assist devices (VADs) have become utilized in a biventricular setup to combat right ventricular failure (RVF) following LVAD implantation. With the advent of continuous-flow LVADs (CF-LVADs) superseding their pulsatile predecessors, the shift towards CF-biventricular assist devices (CF-BiVADs) come with the prospect of improved outcomes over previous pulsatile BiVADs. We aim to review the literature and determine the outcomes of CF-BiVAD recipients., Methods: A systematic review was performed to determine the outcomes of CF-BiVADs. Pre-operative demographics and device configuration data was collected. Primary outcomes evaluated were short-term survival, long-term survival, duration of support, and survival to transplant. Secondary outcomes evaluated included intensive care unit (ICU) and hospital length of stay (ICU-LOS and HLOS, respectively), pump thrombosis, pump exchange. Median and interquartile range was reported where appropriate. A major limitation was the likely overlap of cohorts across publications, which may have contributed to some selection bias., Results: Of 1,282 screened, 12 publications were evaluated. Sample size ranged from 4 to 93 CF-BiVAD recipients, and follow-up ranged from 6 to 24 months. Mean age ranged from 34 to 52 years old. Forty-five percent of CF-BiVADs had right atrial (RA-) inflow cannulation, with the remaining being right ventricular (RV). Thirty-day survival was a median of 90% (IQR 82-97.8%) and 12-month survival was a median of 58.5% (IQR 47.5-62%). Where reported, rate of pump thrombosis (predominantly the right VAD) was a median of 31% (IQR 14-36%), although pump exchange was only 9% (IQR 1.5-12.5%)., Conclusions: RVF post-LVAD implantation is a high morbidity and mortality complication. There is no on-label continuous-flow RVAD currently available. Thus, the modifications of LVADs for right ventricular support to combat pump thrombosis has resulted in various techniques. BiVAD recipients are predominantly transplant candidates, and complications of pump thrombosis and driveline infection whilst on wait-list are of great consequence. This study demonstrates the need for an on-label CF-BiVAD., Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare., (2021 Annals of Cardiothoracic Surgery. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
26. Outcome after surgical stabilization of rib fractures versus nonoperative treatment in patients with multiple rib fractures and moderate to severe traumatic brain injury (CWIS-TBI).
- Author
-
Prins JTH, Van Lieshout EMM, Ali-Osman F, Bauman ZM, Caragounis EC, Choi J, Christie DB 3rd, Cole PA, DeVoe WB, Doben AR, Eriksson EA, Forrester JD, Fraser DR, Gontarz B, Hardman C, Hyatt DG, Kaye AJ, Ko HJ, Leasia KN, Leon S, Marasco SF, McNickle AG, Nowack T, Ogunleye TD, Priya P, Richman AP, Schlanser V, Semon GR, Su YH, Verhofstad MHJ, Whitis J, Pieracci FM, and Wijffels MME
- Subjects
- Adult, Brain Injuries, Traumatic diagnosis, Brain Injuries, Traumatic therapy, Critical Care, Female, Fractures, Multiple diagnosis, Humans, Length of Stay, Male, Middle Aged, Odds Ratio, Postoperative Complications epidemiology, Respiration, Artificial, Retrospective Studies, Rib Fractures diagnosis, Treatment Outcome, Brain Injuries, Traumatic complications, Fracture Fixation, Fractures, Multiple complications, Fractures, Multiple surgery, Rib Fractures complications, Rib Fractures surgery
- Abstract
Background: Outcomes after surgical stabilization of rib fractures (SSRF) have not been studied in patients with multiple rib fractures and traumatic brain injury (TBI). We hypothesized that SSRF, as compared with nonoperative management, is associated with favorable outcomes in patients with TBI., Methods: A multicenter, retrospective cohort study was performed in patients with rib fractures and TBI between January 2012 and July 2019. Patients who underwent SSRF were compared to those managed nonoperatively. The primary outcome was mechanical ventilation-free days. Secondary outcomes were intensive care unit length of stay and hospital length of stay, tracheostomy, occurrence of complications, neurologic outcome, and mortality. Patients were further stratified into moderate (GCS score, 9-12) and severe (GCS score, ≤8) TBI., Results: The study cohort consisted of 456 patients of which 111 (24.3%) underwent SSRF. The SSRF was performed at a median of 3 days, and SSRF-related complication rate was 3.6%. In multivariable analyses, there was no difference in mechanical ventilation-free days between the SSRF and nonoperative groups. The odds of developing pneumonia (odds ratio [OR], 0.59; 95% confidence interval [95% CI], 0.38-0.98; p = 0.043) and 30-day mortality (OR, 0.32; 95% CI, 0.11-0.91; p = 0.032) were significantly lower in the SSRF group. Patients with moderate TBI had similar outcome in both groups. In patients with severe TBI, the odds of 30-day mortality was significantly lower after SSRF (OR, 0.19; 95% CI, 0.04-0.88; p = 0.034)., Conclusion: In patients with multiple rib fractures and TBI, the mechanical ventilation-free days did not differ between the two treatment groups. In addition, SSRF was associated with a significantly lower risk of pneumonia and 30-day mortality. In patients with moderate TBI, outcome was similar. In patients with severe TBI a lower 30-day mortality was observed. There was a low SSRF-related complication risk. These data suggest a potential role for SSRF in select patients with TBI., Level of Evidence: Therapeutic, level IV., (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
27. Apoptotic Markers in Donor Hearts After Brain Death vs Circulatory Death.
- Author
-
Marasco SF, Arthur JF, Ou R, Bailey M, and Rosenfeldt F
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Prospective Studies, Tissue Donors, Brain Death, Death, Heart, Heart Transplantation, Transplants pathology
- Abstract
Background: Use of donation after circulatory death (DCD) hearts is becoming more prevalent in cardiac transplantation. However, there is no standardized approach to myocardial preservation, and little data exists on ultrastructural changes in DCD hearts. We have previously identified increased proapoptotic and proinflammatory activity in brain dead donor (BDD) hearts that subsequently exhibit primary graft failure and lower levels in DCD left atrial tissue. This study further investigates these markers and correlates them with cardiac function in DCD hearts., Methods: This prospective study used donor hearts deemed unsuitable for transplant after gaining institutional ethics approval; 11 human hearts were obtained from 5 DCD donors and 6 BDDs. All hearts were preserved by continuous microperfusion for 4 hours with a cold crystalloid solution and then were evaluated on a blood perfusion bench rig. After 4 hours perfusion and working assessment, tissues from all cardiac chambers were stored for later messenger RNA (mRNA) analysis for proapoptotic and proinflammatory markers., Results: Significantly raised levels of caspase-1, BNIP3, and NADPH oxidase mRNA expression were identified in cardiac chambers from BDD hearts compared to DCD hearts, and these differences were exaggerated in older donors. In the pooled analysis, lower expression of caspase-1, NF-κB1, and BNIP3 mRNA correlated with developed pressure at 1 hour after reperfusion in the right ventricle, but not the left., Conclusion: Compared to BDD hearts, DCD hearts exhibit less stimulation of proapoptotic cascades and reactive oxygen species, potentially reducing their susceptibility to ischemic reperfusion injury., (Crown Copyright © 2020. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
28. Post Cardiotomy Extra Corporeal Membrane Oxygenation: Australian Cohort Review.
- Author
-
Farag J, Summerhayes R, Shen R, Bailey M, Williams-Spence J, Reid CM, and Marasco SF
- Subjects
- Australia epidemiology, Female, Heart Diseases epidemiology, Humans, Male, Middle Aged, Morbidity trends, New Zealand epidemiology, Prognosis, Retrospective Studies, Cardiac Surgical Procedures, Extracorporeal Membrane Oxygenation methods, Heart Diseases surgery
- Abstract
Background: Over the last two decades, technological advancements in the delivery of extra corporeal membrane oxygenation (ECMO) have seen its use broaden and results improve. However, in the post cardiotomy ECMO patient group, survival remains very poor without significant improvements over the last two decades. Our study aims to report on the Australian experience, with the intention of providing background data for the formation of guidelines in the future., Methods: Retrospective analysis of prospectively collected data from the Australian and New Zealand Society of Cardiothoracic Surgeons (ANZSCTS) Database was performed. The ANZSCTS database captures at least 60% of cardiac surgical data in Australia, annually. Data was collected on adult patients who received ECMO post cardiotomy from September 2016 to November 2017 inclusive. Transplant and primary cardiomyopathy patients were excluded., Results: Of the 16,605 adult patients undergoing cardiac surgery in the 15-month period of the study, 87 patients required post cardiotomy ECMO (0.52%). The average age of the entire cohort was 56 years. Overall survival to discharge was 43.7% (n=38). Multivariable logistic regression analysis demonstrated that multiorgan failure (MOF), increasing age and longer cardiopulmonary bypass time were significant predictors of in hospital mortality., Conclusions: Post cardiotomy ECMO support is an uncommon condition. Survival in this study appears to be better than historical reports. Identification of poor prognostic indicators in this study may help inform the development of guidelines for the most appropriate use of this support modality., (Crown Copyright © 2020. Published by Elsevier B.V. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
29. Emergency department resuscitative thoracotomy at an adult major trauma centre: Outcomes following a training programme with standardised indications.
- Author
-
Fitzgerald MC, Yong MS, Martin K, Zimmet A, Marasco SF, Mathew J, Smit V, Yeung M, Tan GA, Marquez M, Cheung Z, Boo E, and Mitra B
- Subjects
- Adult, Emergency Service, Hospital, Humans, Resuscitation, Retrospective Studies, Trauma Centers, Thoracic Injuries surgery, Thoracotomy
- Abstract
Objective: The objective of this study was to report the procedural incidence and patient outcomes after the 2009 introduction of an institutional resuscitative thoracotomy (RT) programme. Emergency physicians, general surgeons and emergency nursing trauma team members were trained to perform RT on thoracic trauma patients with an unresponsive systolic blood pressure (SBP) <70 mmHg within 30 min of arrival, prior to cardiothoracic team back-up., Methods: A retrospective cohort study was conducted on patients who underwent RT from 2009 to 2017. The primary outcome measures were the incidence of the procedure and patients' survival to hospital discharge. Variables associated with survival were assessed using univariable logistic regression analyses., Results: There were 12 399 major trauma patients, including 7657 with major thoracic trauma and 315 presenting with SBP <70 mmHg. There were 32 RTs performed (incidence of 0.4%; 95% confidence interval [CI] 0.3-0.6) among patients with major thoracic trauma and 10.2% (99% CI 7.3-13.4) among patients with major thoracic trauma and SBP <70 mmHg. There were eight (25%; 95% CI 13.2-42.1) survivors to hospital discharge and no late mortality (mean follow-up 2.8 years). Survival was significantly associated with the procedure performed within 30 min of arrival (odds ratio 0.09; 95% CI 0.01-0.67) while mortality was associated with the procedure being performed in the setting of traumatic cardiac arrest (odds ratio 18.3; 95% CI 2.4-140.4)., Conclusions: A formal training and credentialing programme was associated with a low incidence of the procedure, yet achieved a survival rate of 25%, which is comparable to other reported literature., (© 2020 Australasian College for Emergency Medicine.)
- Published
- 2020
- Full Text
- View/download PDF
30. Selective brain hypothermia: feasibility and safety study of a novel method in five patients.
- Author
-
Seyedsaadat SM, Marasco SF, Daly DJ, McEgan R, Anderson J, Rodgers S, Kreck T, Kadirvel R, and Kallmes DF
- Subjects
- Aged, Aged, 80 and over, Feasibility Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Brain physiopathology, Brain Injuries therapy, Hypothermia, Induced methods
- Abstract
Background/objective: Reduction of brain temperature remains the most common method of neuroprotection against ischemic injury employed during cardiac surgery. However, cooling delivered via the cardiopulmonary bypass circuit is brief and cooling the body core along with the brain has been associated with a variety of unwanted effects. This study investigated the feasibility and safety of a novel selective brain cooling approach to induce rapid, brain-targeted hypothermia independent of the cardiopulmonary bypass circuit., Methods: This first-in-human feasibility study enrolled five adults undergoing aortic valve replacement with cardiopulmonary bypass support. During surgery, the NeuroSave system circulated chilled saline within the pharynx and upper esophagus. Brain and body core temperature were continuously monitored. Adverse effects, cardiopulmonary function, and device function were noted., Results: Patient 1 received cooling fluid for an insignificant period, and Patients 2-5 successfully underwent the cooling procedure using the NeuroSave system for 56-89 minutes. Cooling fluid was 12°C for Patients 1-3, 6°C for Patient 4, and 2°C for Patient 5. There were no NeuroSave-related adverse events and no alterations in cardiopulmonary function during NeuroSave use. Brain temperature decreased by 3°C within 15 minutes and remained at least 3.5°C colder than the body core. During a brief episode of hypotension in one patient, the brain cooled an additional 4°C in 2 minutes, briefly reaching 27.4°C., Conclusion: The NeuroSave system can induce rapid brain-targeted hypothermia and simultaneously maintain a favorable body-brain temperature gradient, even during hypotension. Further studies are required to evaluate the function of the system during longer periods of use.
- Published
- 2020
- Full Text
- View/download PDF
31. A donor PaO 2 /FiO 2 < 300 mm Hg does not determine graft function or survival after lung transplantation.
- Author
-
Whitford H, Kure CE, Henriksen A, Hobson J, Snell GI, Levvey BJ, Marasco SF, Gooi JH, Zimmet A, Negri J, Pick A, Buckland M, Williams T, Westall G, Paraskeva MA, Martin C, and McGiffin DC
- Subjects
- Adult, Female, Follow-Up Studies, Humans, Lung physiopathology, Male, Middle Aged, Prospective Studies, Extracorporeal Circulation methods, Graft Survival physiology, Lung metabolism, Lung Transplantation methods, Organ Preservation methods, Perfusion methods, Tissue Donors
- Abstract
Background: A donor arterial PO
2 /FiO2 (P/F ratio) of less than the 300 threshold would frequently result in either exclusion of the donor or placement of the lungs on ex vivo lung perfusion (EVLP). The aim was to investigate the veracity of the P/F ratio threshold of 300 for donor lung acceptability., Methods: In 93 brain dead lung donors, arterial blood gases were drawn in the intensive care unit (ICU) just before procurement and each of the 4 donor pulmonary veins in the operating room (OR). No donor lungs were rejected for transplantation based on the last ICU or OR P/F ratio, and EVLP was not used. The recipients were followed up 6 and 12 months following transplantation., Results: There were 93 recipients of bilateral lung transplantation. An arterial P/F ratio of < 300 was largely driven by a low P/F ratio in the lower lobes. There were no differences between the recipients receiving donor lungs where the ICU P/F ratio was < 300 compared with ≥ 300 in the time to extubation, grade of primary graft dysfunction, pulmonary function at 6 and 12 months, and 12-month survival., Conclusions: From this study:(1) If a donor P/F threshold of 300 was adhered to, 36% would have been rejected, and (2) The donor P/F ratio threshold of 300 is excessively conservative and results in the wastage of donor lungs and the application of unnecessary EVLP., (Copyright © 2019. Published by Elsevier Inc.)- Published
- 2020
- Full Text
- View/download PDF
32. A real-life experience with HeartMate III.
- Author
-
Marasco SF, Farag J, Kure C, Summerhayes R, Bailey M, and McGiffin D
- Subjects
- Equipment Design, Female, Follow-Up Studies, Heart Failure physiopathology, Humans, Incidence, Male, Middle Aged, Retrospective Studies, Survival Rate trends, Time Factors, Treatment Outcome, Ventricular Function, Left physiology, Victoria epidemiology, Heart Failure surgery, Heart Ventricles physiopathology, Heart-Assist Devices, Postoperative Complications epidemiology
- Abstract
Background: The HeartMate III (HM3) left ventricular assist device (LVAD) is the most recent LVAD to receive CE Mark and the Food and Drug Administration approval. It is a fully magnetically levitated pump with no reported haemolysis, pump thrombosis or pump failure in the first in-man study (a previous stody). It has now received market approval in the European Union, United States of America, and Australia. We reviewed our real-life experience with the device, to assess outcomes over the medium term., Methods: We conducted a retrospective review of prospectively collected data for 33 consecutive patients implanted with a HM3 LVAD between November 2014 and October 2018 at The Alfred Hospital, Melbourne, Australia., Results: Of the 33 patients, 31 remained alive at the census date, with only two early deaths and 11 patients transplanted. There were no pump thromboses, but there were three cases of clot ingestion (two on the right and one on the left). Seven patients required permanent biventricular assist device support. The duration of HM3 support at the time of census was a median of 196 (interquartile range, 118-386) days., Conclusion: This series demonstrates excellent results of the HM3 LVAD in an uncensored, real-life, consecutive group of patients in a single institution., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
- Full Text
- View/download PDF
33. Rapid deployment of an aortic valve prosthesis during ventricular assist device implantation.
- Author
-
Gangahanamaiah S and Marasco SF
- Subjects
- Heart Failure complications, Heart Valve Diseases complications, Humans, Male, Middle Aged, Prosthesis Implantation methods, Time Factors, Aortic Valve surgery, Heart Failure surgery, Heart Valve Diseases surgery, Heart Valve Prosthesis Implantation methods, Heart-Assist Devices
- Published
- 2019
- Full Text
- View/download PDF
34. Impact of rib fixation on quality of life after major trauma with multiple rib fractures.
- Author
-
Marasco SF, Martin K, Niggemeyer L, Summerhayes R, Fitzgerald M, and Bailey M
- Subjects
- Adult, Aged, Analgesia statistics & numerical data, Australia, Female, Flail Chest physiopathology, Flail Chest surgery, Fracture Fixation, Internal, Fracture Healing physiology, Humans, Intensive Care Units, Male, Middle Aged, Respiration, Artificial, Retrospective Studies, Rib Fractures complications, Rib Fractures physiopathology, Rib Fractures surgery, Surveys and Questionnaires, Thoracic Injuries complications, Thoracic Injuries physiopathology, Thoracic Injuries surgery, Time Factors, Young Adult, Flail Chest psychology, Length of Stay statistics & numerical data, Pain psychology, Quality of Life psychology, Rib Fractures psychology, Thoracic Injuries psychology
- Abstract
Introduction: Multiple rib fractures have been shown to reduce quality of life both in the short and long term. Treatment of rib fractures with operative fixation reduces ventilator requirements, intensive care unit stay, and pulmonary complications in flail chest patients but has not been shown to improve quality of life in comparative studies to date. We therefore wanted to analyse a large cohort of multiple fractured rib trauma patients to see if rib fixation improved their quality of life., Methods: Retrospective review (January 2012 - April 2015) of prospectively collected data on 1482 consecutive major trauma patients admitted to The Alfred Hospital with rib fractures. The main outcome measures were Quality of Life over 24 months post injury assessed using the Glasgow Outcome Scale Extended (GOSErate) and Short Form (SF12) health assessment forms and a pain questionnaire., Results: 67 (4.5%) patients underwent rib fixation and were older, with a higher incidence of flail chest injury, and higher AIS and ISS scores than the remainder of the cohort. Rib fixation provided no benefit in pain, SF-12 or GOSErate scores over 24 months post injury., Conclusions: This study has not been able to demonstrate any quality of life benefit of rib fixation over 24 months post injury in patients with major trauma., (Copyright © 2018. Published by Elsevier Ltd.)
- Published
- 2019
- Full Text
- View/download PDF
35. To zip or wire: An ongoing debate.
- Author
-
Marasco SF, Fuller L, Zimmet A, and McGiffin D
- Subjects
- Prospective Studies, Polymers, Sternotomy
- Published
- 2018
- Full Text
- View/download PDF
36. Prospective, randomized, controlled trial of polymer cable ties versus standard wire closure of midline sternotomy.
- Author
-
Marasco SF, Fuller L, Zimmet A, McGiffin D, Seitz M, Ch'ng S, Gangahanumaiah S, and Bailey M
- Subjects
- Aged, Analgesics administration & dosage, Female, Humans, Male, Middle Aged, Pain Measurement, Pain, Postoperative etiology, Pain, Postoperative prevention & control, Prospective Studies, Time Factors, Treatment Outcome, Victoria, Wound Closure Techniques adverse effects, Biocompatible Materials, Bone Wires, Polymers, Stainless Steel, Sternotomy adverse effects, Wound Closure Techniques instrumentation
- Abstract
Objective: Midline sternotomy remains the most common access incision for cardiac operations. Traditionally, the sternum is closed with stainless steel wires. Wires are well known to stretch and break, however, leading to pain, nonunion, and potential deep sternal wound infection. We hypothesized that biocompatible plastic cable ties would achieve a more rigid sternal fixation, reducing postoperative pain and analgesia requirements., Methods: A prospective, randomized study compared the ZIPFIX (De Puy Synthes, West Chester, Pa) sternal closure system (n = 58) with standard stainless steel wires (n = 60). Primary outcomes were pain and analgesia requirements in the early postoperative period. Secondary outcome was sternal movement, as assessed by ultrasound at the postoperative follow-up visit., Results: Groups were well matched in demographic and operative variables. There were no significant differences between groups in postoperative pain, analgesia, or early ventilatory requirements. Patients in the ZIPFIX group had significantly more movement in the sternum and manubrium on ultrasound at 4 weeks., Conclusions: ZIPFIX sternal cable ties provide reliable closure but no demonstrable benefit in this study in pain or analgesic requirements relative to standard wire closure after median sternotomy., (Crown Copyright © 2018. Published by Elsevier Inc. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
37. Donor Lung Procurement by Surgical Fellow With an Expectation of High Rate of Lung Utilisation.
- Author
-
Smail H, Saxena P, Wallinder A, Lin E, Snell GI, Hobson J, Zimmet AD, Marasco SF, and McGiffin DC
- Subjects
- Humans, Education, Medical, Graduate, Lung surgery, Lung Transplantation education, Surgeons education, Tissue Donors, Tissue and Organ Procurement methods
- Abstract
There is an ever increasing demand for donor lungs in patients waiting for transplantation. Lungs of many potential donors will be rejected if the standard criteria for donor assessment are followed. We have expanded our donor lung pool by accepting marginal donors and establishing a donation after circulatory death program. We have achieved comparable results using marginal donors and accepting donor lungs following donation after circulatory death. We present our assessment and technical guidelines on lung procurement taking into consideration an increasingly complex cohort of lung donors. These guidelines form the basis of the lung procurement training program involving surgical Fellows at the Alfred Hospital in Melbourne, Australia., (Copyright © 2017 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
38. A Phase 1 Study of a Novel Bidirectional Perfusion Cannula in Patients Undergoing Femoral Cannulation for Cardiac Surgery.
- Author
-
Marasco SF, Tutungi E, Vallance SA, Udy AA, Negri JC, Zimmet AD, McGiffin DC, Pellegrino VA, and Moshinsky RA
- Subjects
- Adult, Aged, Aortic Aneurysm, Thoracic surgery, Aortic Valve surgery, Cardiopulmonary Bypass methods, Cardiopulmonary Bypass statistics & numerical data, Catheterization, Peripheral adverse effects, Equipment Design, Female, Femoral Artery diagnostic imaging, Humans, Ischemia pathology, Male, Middle Aged, Minimally Invasive Surgical Procedures methods, Mitral Valve surgery, Peripheral Vascular Diseases diagnostic imaging, Peripheral Vascular Diseases pathology, Spectroscopy, Near-Infrared methods, Ultrasonography, Doppler, Cannula standards, Cardiac Surgical Procedures methods, Catheterization, Peripheral methods, Femoral Artery surgery, Perfusion instrumentation, Peripheral Vascular Diseases complications
- Abstract
Objective: Leg ischemia is a serious complication of femoral artery cannulation. The primary aim of this study was to assess the safety and efficacy of a novel bidirectional femoral arterial cannula (Sorin Group USA, a wholly owned subsidiary of LivaNova PLC, Arvada, CO USA) that provides both antegrade and retrograde flow, in patients undergoing peripheral cannulation for cardiopulmonary bypass during cardiac surgery., Methods: Patients undergoing routine cardiac surgery requiring femoral artery cannulation for cardiopulmonary bypass were identified preoperatively. Informed written consent was obtained in all cases. Bidirectional cannula insertion used either a surgical cut-down and wire through needle approach or a percutaneous technique. Flow in the superficial femoral artery was assessed using Doppler ultrasound after commencement of cardiopulmonary bypass. Lower limb perfusion was assessed using reflectance near-infrared spectroscopy to measure regional oxygen saturations in the cannulated limb during cardiopulmonary bypass., Results: Fifteen patients (median age = 61.3 years, range = 26-79 years, 10 males, 5 females) underwent femoral arterial cannulation using the novel bidirectional femoral cannula between August 2016 and May 2017. Fourteen cannulae were inserted directly into the femoral artery via a surgical cut-down and wire through needle technique. One bidirectional cannula was inserted using a percutaneous insertion technique. Indications included minimally invasive mitral and aortic valve surgery, thoracic aortic aneurysm repair, and redo cardiac surgery. The median duration of cardiopulmonary bypass was 129 minutes (range = 53-228 minutes). The cannula was inserted and positioned without difficulty in 14 of 15 patients. Incorrect sizing and arterial spasm prevented correct cannula positioning in one patient. Antegrade flow in the superficial femoral artery was observed on Doppler ultrasound in 12 of 12 patients in which this was performed. Continuous stable distal perfusion was demonstrated in the cannulated limb in 14 of 15 patients. No procedural complications occurred in the immediate or convalescent postoperative period., Conclusions: This study demonstrates that in patients undergoing femoral arterial cannulation for cardiopulmonary bypass during cardiac surgery, the use of a novel bidirectional cannula is safe and easy to insert and provides stable distal perfusion of the cannulated limb. Use of the device should largely obviate the need to insert a separate downstream perfusion cannula or use other techniques to protect against lower limb ischemia. Further research on a larger scale and in different patient populations is now warranted.
- Published
- 2018
- Full Text
- View/download PDF
39. Novel Sternal Protection Device for Cardiac Surgery Via Median Sternotomy Incision.
- Author
-
Marasco SF, McGiffin DC, Zimmet AD, Solis PC, Bingham JM, and Moshinsky RA
- Subjects
- Aged, Aortic Valve surgery, Cardiac Surgical Procedures methods, Coronary Artery Bypass methods, Female, Humans, Male, Mammary Arteries surgery, Middle Aged, Myocardial Revascularization methods, Palmitates adverse effects, Palmitates therapeutic use, Pilot Projects, Sternotomy methods, Stress, Mechanical, Surgical Instruments adverse effects, Treatment Outcome, Waxes adverse effects, Waxes therapeutic use, Wound Healing, Cardiac Surgical Procedures instrumentation, Hemorrhage prevention & control, Myocardial Revascularization instrumentation, Protective Devices standards, Sternotomy instrumentation, Sternum surgery
- Abstract
Objective: Sternal bleeding during cardiac surgery is currently controlled using bone wax or other chemical substances that may result in adverse effects and affect wound healing and recovery. The purpose of this study was to identify a safe, cost-effective, and easy-to-use technique to reduce sternal bleeding and sternal trauma during cardiac surgery., Methods: After sternotomy, a sternal protection device was placed over each hemisternal section before insertion of the retractor and remained in situ until the end of surgery. Sternal bleeding and ease of use were assessed and recorded during surgery. Sternal trauma was assessed and recorded within 5 minutes of removal of the device, and overall satisfaction (Global Impression) and any intraoperative adverse events or device malfunction were reported at surgery completion. Patients were followed up 24 hours and 4 weeks after surgery., Results: Twelve patients completed the study. Adverse events reported were not considered related to the device. No sternal trauma was identified in any patient. In 9 of 11 patients, sternal bleeding was reduced after insertion of the device. The device was generally considered easy to use, although some difficulty was encountered when used with the Internal Mammary Artery retractor., Conclusions: Our data suggest that the device is safe and able to reduce sternal bleeding during surgery using sternal retractors. We recommend further studies in a larger population of patients with a control group to evaluate the device's ability to reduce the morbidity associated with sternal bleeding and sternal trauma.
- Published
- 2017
- Full Text
- View/download PDF
40. Intra-operative protective mechanical ventilation in lung transplantation: a randomised, controlled trial.
- Author
-
Verbeek GL, Myles PS, Westall GP, Lin E, Hastings SL, Marasco SF, Jaffar J, and Meehan AC
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Oxygen blood, Positive-Pressure Respiration, Lung Transplantation adverse effects, Respiration, Artificial methods, Ventilator-Induced Lung Injury prevention & control
- Abstract
Primary graft dysfunction occurs in up to 25% of patients after lung transplantation. Contributing factors include ventilator-induced lung injury, cardiopulmonary bypass, ischaemia-reperfusion injury and excessive fluid administration. We evaluated the feasibility, safety and efficacy of an open-lung protective ventilation strategy aimed at reducing ventilator-induced lung injury. We enrolled adult patients scheduled to undergo bilateral sequential lung transplantation, and randomly assigned them to either a control group (volume-controlled ventilation with 5 cmH
2 O, positive end-expiratory pressure, low tidal volumes (two-lung ventilation 6 ml.kg-1 , one-lung ventilation 4 ml.kg-1 )) or an alveolar recruitment group (regular step-wise positive end-expiratory pressure-based alveolar recruitment manoeuvres, pressure-controlled ventilation set at 16 cmH2 O with 10 cmH2 O positive end-expiratory pressure). Ventilation strategies were commenced from reperfusion of the first lung allograft and continued for the duration of surgery. Regular PaO2 /FI O2 ratios were calculated and venous blood samples collected for inflammatory marker evaluation during the procedure and for the first 24 h of intensive care stay. The primary end-point was the PaO2 /FI O2 ratio at 24 h after first lung reperfusion. Thirty adult patients were studied. The primary outcome was not different between groups (mean (SD) PaO2 /FI O2 ratio control group 340 (111) vs. alveolar recruitment group 404 (153); adjusted p = 0.26). Patients in the control group had poorer mean (SD) PaO2 /FI O2 ratios at the end of the surgical procedure and a longer median (IQR [range]) time to tracheal extubation compared with the alveolar recruitment group (308 (144) vs. 402 (154) (p = 0.03) and 18 (10-27 [5-468]) h vs. 15 (11-36 [5-115]) h (p = 0.01), respectively). An open-lung protective ventilation strategy during surgery for lung transplantation is feasible, safe and achieves favourable ventilation parameters., (© 2017 The Association of Anaesthetists of Great Britain and Ireland.)- Published
- 2017
- Full Text
- View/download PDF
41. Outcomes of ventricular assist device implantation in children and young adults: the Melbourne experience.
- Author
-
Shi WY, Marasco SF, Saxena P, d'Udekem Y, Yong MS, Mitnovetski S, Brizard CP, McGiffin DC, Weintraub RG, and Konstantinov IE
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Female, Heart Defects, Congenital mortality, Heart Transplantation, Humans, Infant, Infant, Newborn, Male, Retrospective Studies, Survival Rate trends, Treatment Outcome, Victoria epidemiology, Young Adult, Heart Defects, Congenital therapy, Heart-Assist Devices
- Abstract
Background: We evaluated our experience with ventricular assist device (VAD) implantation in children and young adults., Methods: A total of 64 patients underwent VAD implantation in two centres. The mean age was 15 ± 7.2 years. Thirty-five (55%) patients were under 18 years of age. Devices implanted included the Thoratec Paracorporeal in 30 (47%) patients, Berlin Heart EXCOR in 11 (17%) and VentrAssist in 14 (22%). The diagnosis was cardiomyopathy in 53, congenital heart disease in 11, and graft failure in four patients., Results: There were 10 (16%) in-hospital deaths. Mortality was higher in patients <18 years of age (26% compared with 3.4% for those ≥18 years, P = 0.02). The use of extracorporeal membrane oxygenation prior to VAD implantation was associated with higher mortality (P = 0.006). Seventeen (27%) patients experienced stroke. Nine patients (14%) required change of VAD because of thrombosis. Transplantation was performed in 44 patients after a mean of 131 ± 141 days on VAD, 11 patients died without transplantation and three patients currently await transplantation. The VAD was explanted in six patients because of recovery. Overall survival from VAD implantation was 69% and 61% at 5 and 10 years, respectively. The 5-year post-transplant survival for those bridged with VAD support was 91% and was comparable with a cohort of patients who did not receive a pre-transplant VAD., Conclusions: Children requiring pre-transplant VAD support have a higher mortality and morbidity compared with young adults. Survival after heart transplantation those supported with VADs was similar to patients of similar age who did not require pre-transplant support., (© 2015 Royal Australasian College of Surgeons.)
- Published
- 2016
- Full Text
- View/download PDF
42. Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI.
- Author
-
Lukito P, Wong A, Jing J, Arthur JF, Marasco SF, Murphy DA, Bergin PJ, Shaw JA, Collecutt M, Andrews RK, Gardiner EE, and Davis AK
- Subjects
- Adolescent, Adult, Aged, Aortic Valve Stenosis physiopathology, Blood Platelets metabolism, Cohort Studies, Female, Heart Failure complications, Hemorrhage complications, Heparin therapeutic use, Humans, Male, Middle Aged, Platelet Activation, Stress, Mechanical, Thrombosis, Warfarin therapeutic use, Young Adult, von Willebrand Factor chemistry, Blood Platelets cytology, Extracorporeal Membrane Oxygenation, Heart-Assist Devices, Platelet Glycoprotein GPIb-IX Complex chemistry, Platelet Membrane Glycoproteins chemistry
- Abstract
Essentials Relationship of acquired von Willebrand disease (VWD) and platelet dysfunction is explored. Patients with ventricular assist devices and on extracorporeal membrane oxygenation are investigated. Acquired VWD and platelet receptor shedding is demonstrated in the majority of patients. Loss of platelet adhesion receptors glycoprotein (GP) Ibα and GPVI may increase bleeding risk., Summary: Background Ventricular assist devices (VADs) and extracorporeal membrane oxygenation (ECMO) are associated with bleeding that is not fully explained by anticoagulant or antiplatelet use. Exposure of platelets to elevated shear in vitro leads to increased shedding. Objectives To investigate whether loss of platelet receptors occurs in vivo, and the relationship with acquired von Willebrand syndrome (AVWS). Methods Platelet counts, coagulation tests and von Willebrand factor (VWF) analyses were performed on samples from 21 continuous flow VAD (CF-VAD), 20 ECMO, 12 heart failure and seven aortic stenosis patients. Levels of platelet receptors were measured by flow cytometry or ELISA. Results The loss of high molecular weight VWF multimers was observed in 18 of 19 CF-VAD and 14 of 20 ECMO patients, consistent with AVWS. Platelet receptor shedding was demonstrated by elevated soluble glycoprotein (GP) VI levels in plasma and significantly reduced surface GPIbα and GPVI levels in CF-VAD and ECMO patients as compared with healthy donors. Platelet receptor levels were also significantly reduced in heart failure patients. Conclusions These data link AVWS and increased platelet receptor shedding in patients with CF-VADs or ECMO for the first time. Loss of the platelet surface receptors GPIbα and GPVI in heart failure, CF-VAD and ECMO patients may contribute to ablated platelet adhesion/activation, and limit thrombus formation under high/pathologic shear conditions., (© 2016 International Society on Thrombosis and Haemostasis.)
- Published
- 2016
- Full Text
- View/download PDF
43. Fixation of a human rib by an intramedullary telescoping splint anchored by bone cement.
- Author
-
Liovic P, Šutalo ID, and Marasco SF
- Subjects
- Animals, Computer Simulation, Finite Element Analysis, Humans, Hydrodynamics, Models, Theoretical, Stress, Mechanical, Sus scrofa, Bone Cements pharmacology, Fracture Fixation, Intramedullary methods, Rib Fractures surgery, Splints
- Abstract
A novel concept for rib fixation is presented that involves the use of a bioresorbable polymer intramedullary telescoping splint. Bone cement is used to anchor each end of the splint inside the medullary canal on each side of the fracture site. In this manner, rib fixation is achieved without fixation device protrusion from the rib, making the splint completely intramedullary. Finite element analysis is used to demonstrate that such a splint/cement composite can preserve rib fixation subjected to cough-intensity force loadings. Computational fluid dynamics and porcine rib experiments were used to study the anchor formation process required to complete the fixation.
- Published
- 2016
- Full Text
- View/download PDF
44. Heart transplantation in Fontan patients across Australia and New Zealand.
- Author
-
Shi WY, Yong MS, McGiffin DC, Jain P, Ruygrok PN, Marasco SF, Finucane K, Keogh A, d'Udekem Y, Weintraub RG, and Konstantinov IE
- Subjects
- Australia, Catchment Area, Health, Chi-Square Distribution, Child, Child, Preschool, Disease-Free Survival, Female, Fontan Procedure mortality, Fontan Procedure trends, Heart Defects, Congenital diagnosis, Heart Defects, Congenital mortality, Heart Defects, Congenital physiopathology, Humans, Kaplan-Meier Estimate, Male, Multivariate Analysis, New Zealand, Nonlinear Dynamics, Postoperative Complications diagnosis, Postoperative Complications mortality, Postoperative Complications physiopathology, Proportional Hazards Models, Referral and Consultation, Registries, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, Fontan Procedure adverse effects, Healthcare Disparities trends, Heart Defects, Congenital surgery, Heart Transplantation adverse effects, Heart Transplantation mortality, Heart Transplantation trends, Postoperative Complications surgery
- Abstract
Objective: Patients with Fontan physiology may eventually require heart transplantation (HT). We determined the rates and outcomes of HT in a national, population-based multicentre study., Methods: From 1990 to 2015, 1369 patients underwent the Fontan procedure as recorded in the Australia and New Zealand Fontan Registry. We identified those who underwent HT and analysed their outcomes. We compared rates of HT between two catchment areas. In area 1 (n=721), patients were referred to the national paediatric HT programme or its associated adult programme. In area 2 (n=648), patients were referred to the national paediatric HT programme or one of the other adult HT programmes., Results: Mean follow-up time post-Fontan was 11±8 years. Freedom from Fontan failure was 74%±3.9% at 20 years. HT was performed in 34 patients. Patients living in area 1 were more likely to have HT (4.0%, 29/721 vs 0.8%, 5/648, p<0.001) with a cumulative proportion of 3.4% vs 0.7% at 10 years and 6.8% vs 1.2% at 20 years (p=0.002). Area 1 patients were more likely to undergo HT (hazard ratio 4.7, 95% CI 1.7 to 13.5, p=0.003) on multivariable regression. Post-HT survival at 1, 5 and 10 years was 91%, 78% and 71%, respectively. Compared with other patients with congenital heart disease (n=87), Fontan patients had similar in-hospital outcomes and long-term survival., Conclusions: Although HT after the Fontan procedure can be achieved with excellent outcomes, most patients with Fontan failure do not undergo HT. Significant regional differences in rates of HT in Fontan patients exist., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/)
- Published
- 2016
- Full Text
- View/download PDF
45. Increasing Complexity of Heart Transplantation in Patients With Congenital Heart Disease.
- Author
-
Shi WY, Saxena P, Yong MS, Marasco SF, McGiffin DC, Shipp A, Weintraub RG, d'Udekem Y, Brizard CP, and Konstantinov IE
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Female, Heart Defects, Congenital diagnostic imaging, Heart Defects, Congenital physiopathology, Hospital Mortality, Humans, Infant, Infant, Newborn, Kaplan-Meier Estimate, Male, Middle Aged, Postoperative Complications etiology, Postoperative Complications mortality, Reoperation, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, Victoria, Young Adult, Heart Defects, Congenital surgery, Heart Transplantation adverse effects
- Abstract
Owing to improved surgical results, there is a growing population of patients with repaired congenital heart disease (CHD) requiring heart transplantation. The objective of the study was to review our experience in these patients. A retrospective review of the outcomes of heart transplantation in patients with CHD (n = 77) between 1988 and 2014 was performed. Outcomes of early (1988-1999) and late (2000-2014) eras were compared. In results, the mean age was 18 ± 14 years (range: 16 days-58 years). Seventy (91%) patients underwent a mean of 2.6 ± 1.3 (range: 1-6) cardiac operations before transplantation, whereas 7 were primary transplants. Univentricular palliation had been performed in 44 (57%) patients. Patients with CHD in the later era had longer mean cardiopulmonary bypass time (early: 190 ± 70 minute vs late: 271 ± 115 minute; P < 0.001), ischemic times (early: 222 ± 98 minute vs late: 275 ± 102 minute; P = 0.039), and more often required reconstruction of the great arteries at the time of transplantation (8% vs 28%; P = 0.036). In those with prior univentricular palliations, the ratio of ischemic to cardiopulmonary bypass time decreased in the later era (early: 1.41 ± 0.60 vs late: 0.99 ± 0.37; P = 0.016), reflecting increased intraoperative complexity. Following transplantation, hospital mortality was 13% (10/77; 7 due to primary graft failure). There was no difference in inhospital mortality between the 2 eras (P = 0.52); however, patients in the later era more often required postoperative extracorporeal membrane oxygenation (early: 8%, 3/38 vs late: 28%, 11/39; P = 0.036). In patients with prior univentricular palliations, those in the late era were more likely to experience postoperative renal impairment (early: 1/21, 5% vs late: 9/23, 39%; P = 0.01). Patients with CHD had higher 30-day mortality (CHD: n = 8, 10% vs non-CHD: n = 17, 3.8%; P = 0.021), but similar survival at 10 years (67% ± 12% vs 70% ± 4.7%; P = 0.87) compared to those without CHD. In conclusion, patients with CHD undergoing cardiac transplantation in the recent era were more complex. They had a greater number of prior cardiac operations, and more often underwent complex vascular reconstructions and required more prolonged intraoperative preparation., (Crown Copyright © 2016. Published by Elsevier Inc. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
46. Cost comparison of heart transplant vs. left ventricular assist device therapy at one year.
- Author
-
Marasco SF, Summerhayes R, Quayle M, McGiffin D, and Luthe M
- Subjects
- Cost-Benefit Analysis, Female, Follow-Up Studies, Graft Rejection etiology, Graft Survival, Heart Failure complications, Heart Failure therapy, Heart Transplantation adverse effects, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Risk Factors, Graft Rejection economics, Heart Failure economics, Heart Transplantation economics, Heart-Assist Devices economics, Pacemaker, Artificial economics
- Abstract
With the worldwide shortage of donor organs, use of ventricular assist device (VAD) therapy is rapidly increasing in both the bridge to transplant and destination therapy settings. However, the high cost of VADs and VAD care is a cause for concern for policy makers who have relied on the limited supply of donor hearts to naturally cap health expenditure on heart transplantation (HTx). We sought to compare costs of the first 12 months of care of VADs vs. HTx. Single center retrospective study utilizing real generated costs over a three yr span from 2010-2012. Only patients with 12 months of costing data were included. Costs of 28 HTx patients and 24 VAD patients were analyzed. Index admission costs were more than double in the VAD group compared to the HTx group and this was driven by the procurement costs and length of stay which increased almost all aspects of in hospital care costs. Subsequent costs were six times higher in the HTx group and this was driven largely by pharmaceuticals. VAD therapy remains a very expensive treatment option for end stage heart failure patients. Device prices need to reduce substantially to make this a more widely applicable and cost effective treatment option., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2016
- Full Text
- View/download PDF
47. Extracorporeal Life Support Bridge to Ventricular Assist Device: The Double Bridge Strategy.
- Author
-
Marasco SF, Lo C, Murphy D, Summerhayes R, Quayle M, Zimmet A, and Bailey M
- Subjects
- Adult, Extracorporeal Membrane Oxygenation adverse effects, Extracorporeal Membrane Oxygenation mortality, Female, Heart Failure diagnosis, Heart Failure mortality, Heart Failure physiopathology, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Prosthesis Design, Recovery of Function, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, Ventricular Function, Left, Victoria, Extracorporeal Membrane Oxygenation instrumentation, Heart Failure therapy, Heart-Assist Devices, Oxygenators, Membrane
- Abstract
In patients requiring left ventricular assist device (LVAD) support, it can be difficult to ascertain suitability for long-term mechanical support with LVAD and eventual transplantation. LVAD implantation in a shocked patient is associated with increased morbidity and mortality. Interest is growing in the utilization of extracorporeal life support (ECLS) as a bridge-to-bridge support for these critically unwell patients. Here, we reviewed our experience with ECLS double bridging. We hypothesized that ECLS double bridging would stabilize end-organ dysfunction and reduce ventricular assist device (VAD) implant perioperative mortality. We conducted a retrospective review of prospectively collected data for 58 consecutive patients implanted with a continuous-flow LVAD between January 2010 and December 2013 at The Alfred Hospital, Melbourne, Victoria, Australia. Twenty-three patients required ECLS support pre-LVAD while 35 patients underwent LVAD implantation without an ECLS bridge. Preoperative morbidity in the ECLS bridge group was reflected by increased postoperative intensive care duration, blood loss, blood product use, and postoperative renal failure, but without negative impact upon survival when compared with the no ECLS group. ECLS stabilization improved end-organ function pre-VAD implant with significant improvements in hepatic and renal dysfunction. This series demonstrates that the use of ECLS bridge to VAD stabilizes end-organ dysfunction and reduces VAD implant perioperative mortality from that traditionally reported in these "crash and burn" patients., (Copyright © 2015 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.)
- Published
- 2016
- Full Text
- View/download PDF
48. Surgical management of tricuspid valve endocarditis in the current era: A review.
- Author
-
Yong MS, Coffey S, Prendergast BD, Marasco SF, Zimmet AD, McGiffin DC, and Saxena P
- Subjects
- Endocarditis complications, Heart Valve Diseases etiology, Humans, Prosthesis Design, Endocarditis surgery, Heart Valve Diseases surgery, Heart Valve Prosthesis, Tricuspid Valve surgery
- Abstract
The incidence of isolated tricuspid valve infective endocarditis is increasing. Medical management is the mainstay of treatment but surgical intervention is required in a subset of patients. Surgical treatment options include valve excision and replacement or valve reconstruction. We searched PubMed and the Cochrane library to identify articles to be included in this review of surgical outcomes. References of selected articles were crosschecked for other relevant studies. Surgical management of tricuspid valve endocarditis can be achieved with satisfactory outcomes. However, the optimal indication and timing of surgery remain unclear, and the frequent association with intravenous drug use complicates management. Repair techniques are preferable though there is no clear evidence supporting one method over another., (Crown Copyright © 2015. Published by Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
49. Tunneling a Pulmonary Artery Graft: A Simplified Way to Insert and Remove a Temporary Right Ventricular Assist Device.
- Author
-
Saxena P and Marasco SF
- Subjects
- Adolescent, Adult, Blood Vessel Prosthesis Implantation methods, Device Removal methods, Female, Heart Failure diagnosis, Heart Failure physiopathology, Humans, Male, Middle Aged, Prosthesis Design, Pulmonary Artery physiopathology, Recovery of Function, Time Factors, Treatment Outcome, Ventricular Function, Left, Young Adult, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation instrumentation, Device Removal instrumentation, Heart Failure therapy, Heart-Assist Devices, Pulmonary Artery surgery, Ventricular Function, Right
- Abstract
Right ventricular failure can occur early or late after left ventricular assist device implantation. Support with a right ventricular assist device is needed in patients whose right ventricular failure does not respond to conservative management. The use of a temporary right ventricular assist device can enable the recovery of right ventricular function and avoid the use of a more permanent biventricular assist device, which is associated with complications and higher costs. We present our technique of instituting temporary right ventricular assist device support in patients who have undergone left ventricular assist device implantation.
- Published
- 2015
- Full Text
- View/download PDF
50. Improving the Exposure of the Left Hilum for Lung Transplantation: The Value of a Simple Pericardial Stitch.
- Author
-
Saxena P, McGiffin DC, Zimmet AD, Gooi JH, Marasco SF, Negri J, and Pick A
- Subjects
- Humans, Lung Transplantation methods
- Published
- 2015
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.