1. Acute promyelocytic leukemia in a long-standing HIV-positive patient: Case report and literature review
- Author
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Daniela P. Mendes-de-Almeida, Teresa de Souza Fernandez, Viviane Lamim Lovatel, Moises Martins da Rocha, Bernadete Evangelho Gomes, Bárbara C.R. Monte-Mór, Danielle Tavares Vianna, Marília T.G. Alcoforado, João Marcello P.B. Kronemberg, João Pedro S.C. Cardoso, Vanessa da Gama Oliveira, Joanna Bokel, Alexandre G. Vizzoni, Estevão Portela Nunes, and Beatriz Grinsztejn
- Subjects
Acute myeloid leukemia ,HIV infection ,AIDS ,Antiretroviral therapy ,Acute promyelocytic leukemia ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
The use of antiretroviral therapy has drastically improved the life quality and prognosis of people living with the human immunodeficiency virus (HIV). The risk of acute myeloid leukemia (AML) currently does not appear to be significantly increased compared to the general population. Acute promyelocytic leukemia (APL), infrequent in people with HIV, is a distinct subtype of AML with unique molecular pathogenesis, clinical manifestations, and treatment. Herein we describe a fatal case of APL hypogranular variant in an HIV-positive patient presenting with hyperleukocytosis. Also, we conducted a literature review of the ten cases reported so far.
- Published
- 2022
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