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2. Periurethral granuloma following injection with dextranomer/hyaluronic acid copolymer for stress urinary incontinence

Author

María-Teresa Castillo-Vico, Miguel Ángel Checa-Vizcaíno, Antonio Payà-Panadés, Ramon Carreras-Collado, and Carolina Rueda-García

Subjects
medicine.medical_specialty, Stress incontinence, Urinary Incontinence, Stress, Urology, Urinary incontinence, Asymptomatic, Injections, Urethral Diseases, medicine, Humans, Hyaluronic Acid, Aged, Granuloma, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, Dextrans, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Surgery, Urethra, medicine.anatomical_structure, Female, Dextranomer, medicine.symptom, business, medicine.drug
Abstract

Periurethral injection of bulk-enhancing agents provides a simpler and cost-effective therapeutic approach for stress incontinence in women. We report a case of periurethral granuloma secondary to dextranomer/hyaluronic acid (Dx/HA) copolymer injection. A 73-year-old woman with history of radiotherapy for cervical carcinoma at the age of 55 presented with stress urinary incontinence. She underwent periurethral injection of Dx/HA copolymer, and incontinence was resolved. At 4 months postoperatively, a 3-4 cm noninflammatory painless mass in the external genitalia was noted. Cystic images compatible with urethral diverticula were seen in the magnetic resonance imaging scan, but voiding cystourethrography was unrevealing. Transvaginal tumor puncture yielded abundant creamy material, the culture of which was negative. Microscopic examination revealed refractile foreign material surrounded by foreign body giant cells. Surgical debridement of the granuloma using a cold scalpel was performed. Stress urinary incontinence recurred but resolved spontaneously within 1 month. One year later, the patient continues to be asymptomatic.

Published
2005
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3. Periurethral granuloma following injection with dextranomer/hyaluronic acid copolymer for stress urinary incontinence.

Author

María-Teresa Castillo-Vico, Miguel Checa-Vizcaíno, Antonio Payà-Panadés, Carolina Rueda-García, and Ramón Carreras-Collado

Subjects
*URINARY incontinence, *HYALURONIC acid, *WOMEN'S health, *THERAPEUTICS
Abstract

AbstractPeriurethral injection of bulk-enhancing agents provides a simpler and cost-effective therapeutic approach for stress incontinence in women. We report a case of periurethral granuloma secondary to dextranomer/hyaluronic acid (Dx/HA) copolymer injection. A 73-year-old woman with history of radiotherapy for cervical carcinoma at the age of 55 presented with stress urinary incontinence. She underwent periurethral injection of Dx/HA copolymer, and incontinence was resolved. At 4 months postoperatively, a 3–4 cm noninflammatory painless mass in the external genitalia was noted. Cystic images compatible with urethral diverticula were seen in the magnetic resonance imaging scan, but voiding cystourethrography was unrevealing. Transvaginal tumor puncture yielded abundant creamy material, the culture of which was negative. Microscopic examination revealed refractile foreign material surrounded by foreign body giant cells. Surgical debridement of the granuloma using a cold scalpel was performed. Stress urinary incontinence recurred but resolved spontaneously within 1 month. One year later, the patient continues to be asymptomatic. [ABSTRACT FROM AUTHOR]

Published
2007

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