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Background: Reduced information-processing speed (IPS) is a primary cognitive deficit of multiple sclerosis (MS) patients. The neural efficiency hypothesis describes an inverse relationship between cognitive performance in a task and the amount of cognitive resources devoted to it. Previous studies have shown that the neural efficiency hypothesis provides an appropriate framework to explore cognitive dysfunction in neurological patients. Objective: The aim of this study was to explore the neural efficiency hypothesis regarding IPS capabilities in cognitively preserved MS patients. Methods: 16 MS patients and 17 healthy controls (HCs) were enrolled and neuropsychologically assessed. All participants also performed a functional magnetic resonance imaging (fMRI)-adapted version of the Symbol Digit Modalities Test (SDMT) at different interstimulus intervals (ISI: 1.5, 2, and 2.5 s). Results: MS patients only displayed lower SDMT performance when the ISI was set at 1.5 s. However, MS patients´ normal SDMT performance at larger ISIs was achieved at the cost of increased brain activation, hence revealing that they were less cognitively efficient than the HCs. Regression analyses confirmed this conclusion by showing an opposite relationship between SDMT performance and the amount of neural resources recruited in the HC and MS groups. Thus, while a positive relationship between both variables was observed in MS patients, this correlation was negative for the HC group. Conclusions: MS patients require more cognitive resources than HCs to achieve a normal SDMT performance, then revealing that they are less efficient regarding IPS capabilities. Fil: Fittipaldi, María Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universitat Jaume I; España Fil: Cruz Gómez, Álvaro Javier. Universitat Jaume I; España Fil: Sanchis Segura, Carla. Universitat Jaume I; España Fil: Belenguer, Antonio. Hospital General de Castellón; España Fil: Ávila, César. Universitat Jaume I; España Fil: Forn, Cristina. Universitat Jaume I; España

Introducción: En los últimos años ha habido un interés creciente en abordar el trata-miento de los trastornos emocionales (te) desde una perspectiva transdiagnóstica. Los protocolos transdiagnósticos enfatizan los procesos esenciales subyacentes a los distintos te, son adecuados para el tratamiento de distintos trastornos psicológicos y permiten un abordaje más adecuado de la comorbilidad entre este tipo de trastornos. Por otra parte, el uso de las tecnologías de la información y la comunicación (tic) puede ayudar a que los tratamientos psicológicos lleguen a un mayor número de personas, contribuyendo de esta manera a mejorar su eficiencia. La mayoría de tra-bajos sobre protocolos de tratamiento online se centran en el estudio de su eficacia, sin embargo es importante también estudiar la aceptabilidad de este tipo de interven-ciones. Nuestro grupo de investigación ha desarrollado un protocolo de tratamiento transdiagnóstico para los te, y lo ha adaptado para que pueda ser aplicado a través de Internet. En este trabajo se describe este protocolo y se presentan datos prelimi-nares sobre su aceptabilidad. metodología: 12 participantes (edad media = 28,58, d. t. = 5,35) de una muestra clínica con un diagnóstico de te que recibieron un pro-tocolo de tratamiento transdiagnóstico combinado (terapia presencial + protocolo de tratamiento online). Se obtuvieron datos acerca de las expectativas y opinión de los participantes evaluadas con la escala de expectativas sobre el tratamiento y la esca-la de opinión sobre el tratamiento. resultados: Las puntuaciones obtenidas fueron elevadas en ambas variables relacionadas con la aceptación (expectativas y opi-nión). discusión: El estudio de la aceptabilidad por parte de los pacientes hacia estos programas es importante, ya que puede influir en la decisión acerca de iniciar y/o seguir este tipo de tratamientos. Contar con esta información puede ayudarnos en el desarrollo y mejora de los tratamientos psicológicos autoaplicados a través de Internet. Introduction: In recent years there has been great interest in addressing the treatment of ed from a transdiagnostic perspective. Transdiagnostic treatment protocols empha-size the essential underlying processes that are common to ed and are conceived of for the treatment of several mental disorders. Also, comorbidity among these disorders can be more adequately addressed from this perspective. In addition, Information and Communication Technologies (icts) can facilitate access by people for whom traditional therapy is not available thereby contributing to an improvement in its cost-effectiveness. Most of the articles about online treatment protocols are efficacy studies, nevertheless it is also important to analyze the acceptability of these types of interventions. Our re-search group has developed a transdiagnostic treatment protocol for the treatment of ed that has been adapted to be applied online over the Internet. The aim of this article is to describe the treatment protocol and to present data about its acceptability. me-thodology: 12 participants (mean age = 28.58, d. t. = 5.35) from a clinical sample with a diagnosis of ed which received a blended transdiagnostic protocol treatment (face-to-face therapy plus online treatment protocol). Scores of expectancies and opinion of treatment were assessed with the Expectancies Treatment Scale and the Opinion Treatment Scale. results: High scores in both variables related to acceptability (expec-tations and opinion of treatment) were obtained. discussion: The study of the accep-tability towards this kind of programs is important, since it may influence the participant’s decision to initiate and/or follow this kind of treatments. Counting on this information can help us in the development and improvement of Internet-based treatment proto-cols.