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Introduction: the emergence of the pandemic caused by the SARS-Cov-2 virus has generated lifestyles changes for humanity. Strategies to prevent exponential contagion and the collapse of health systems such as social-distancing and quarantine have affected people in different ways according to their vulnerability, including marijuana consumers. Objective: to learn if the regular consumers of marijuana who remained in physical and social isolation due to COVID-19 altered or modified their consumption, in their disposition and in their method of supply. Method: a cross-sectional, non-probabilistic and analytical study that used the snowball technique, aimed at regular marijuana consumers in Mexico, of legal age, who have access to the Internet and/or WhatsApp. Results: 50 men and 25 women participated, most from the state of Veracruz; the only mood related variable that was statistically significant was the relief provided by marijuana use and level of marijuana use during quarantine, as well there were changes in consumption, in the method of supply and in the relationship established with the people with whom they live. Conclusions: this work addresses an emerging problem of which little is still known, especially regarding its correlation with mental health and disorders resulting from the use of psychoactive substances. Thus, contributing a building basis for understanding the impact of quarantine and for the attention of marijuana consumers.