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1. Nitrosyl-heme and Heme Iron Intake from Processed Meats and Risk of Colorectal Cancer in the EPIC-Spain Cohort.

Author

Rizzolo-Brime, Lucía, Lujan-Barroso, Leila, Farran-Codina, Andreu, Bou, Ricard, Lasheras, Cristina, Amiano, Pilar, Aizpurua, Amaia, Sánchez, Maria-Jose, Molina-Montes, Esther, Guevara, Marcela, Moreno-Iribas, Conchi, Gasque, Alba, Dolores Chirlaque-López, María, Colorado-Yohar, Sandra M., María Huerta, José, Zamora-Ros, Raul, Agudo, Antonio, and Jakszyn, Paula

Abstract

Background: The International Agency for Research on Cancer classified processed meats (PM) as "carcinogenic" and red meat as "probably carcinogenic" for humans. The possible relationship between colorectal cancer risk and the mechanisms involved in the carcinogenesis of PMs have not been established yet. Nitrosyl-heme and heme iron have been proposed as potential-related compounds. The aim of this study was to determine the association between nitrosyl-heme and heme iron intake and colorectal cancer risk among participants from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain study. Methods: This prospective study included 38,262 men and women from the EPIC-Spain study. Food consumption was assessed using diet history and food composition tables. Heme iron and nitrosyl-heme intake were determined by estimating the intake of PM items and conducting laboratory analyses. HR estimates were obtained by proportional hazard models, stratified by age at recruitment and study center and adjusted for sex, total energy intake, education, smoking, body mass index, waist size, physical activity, lifetime alcohol, fibre, calcium, and familiar colorectal cancer history. Results: During a mean follow-up of 16.7 years, 577 participants were diagnosed with colorectal cancer. We found no overall association between nitrosyl-heme [HRT3vsT1, 0.98; 95% confidence interval (CI), 0.79-1.21] or heme iron intakes (HRT3vsT1, 0.88; 95% CI, 0.70-1.10) with colorectal cancer risk, nor according to tumor subtypes. Conclusions: Our study found no evidence supporting a link between nitrosyl-heme or heme iron intake and colorectal cancer risk in Spanish subjects. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Author

Papadimitriou, Nikos, Dimou, Niki, Tsilidis, Konstantinos K., Banbury, Barbara, Martin, Richard M., Lewis, Sarah J., Kazmi, Nabila, Robinson, Timothy M., Albanes, Demetrius, Aleksandrova, Krasimira, Berndt, Sonja I., Timothy Bishop, D., Brenner, Hermann, Buchanan, Daniel D., Bueno-de-Mesquita, Bas, Campbell, Peter T., Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Ellingjord-Dale, Merete, Figueiredo, Jane C., Gallinger, Steven J., Giles, Graham G., Giovannucci, Edward, Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harlid, Sophia, Harrison, Tabitha A., Hoffmeister, Michael, Hopper, John L., Hsu, Li, María Huerta, José, Huyghe, Jeroen R., Jenkins, Mark A., Keku, Temitope O., Kühn, Tilman, La Vecchia, Carlo, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane M., Lynch, Brigid, Markowitz, Sanford D., Masala, Giovanna, May, Anne M., Milne, Roger, Monninkhof, Evelyn, Moreno, Lorena, Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Perduca, Vittorio, Pharoah, Paul D. P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Riboli, Elio, Sánchez, Maria-Jose, Schmit, Stephanie L., Schoen, Robert E., Severi, Gianluca, Sieri, Sabina, Slattery, Martha L., Song, Mingyang, Tangen, Catherine M., Thibodeau, Stephen N., Travis, Ruth C., Trichopoulou, Antonia, Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., Van Guelpen, Bethany, Vodicka, Pavel, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Peters, Ulrike, Gunter, Marc J., and Murphy, Neil

Published
2020
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3. Association of Dietary Diversity with Incident Type 2 Diabetes by Sex and Obesity Status in Eight European Countries: The Epic-Interact Case-Cohort Study

Author

Mozaffari, Hadis, primary, Imamura, Fumiaki, additional, Murphy, Rachel, additional, Jessri, Mahsa, additional, Sharp, Stephen, additional, Forouhi, Nita, additional, Wareham, Nicholas J., additional, Ibsen, Daniel Borch, additional, Dahm, Christina C., additional, María Huerta, José, additional, Molina-Montes, Esther, additional, Nickel, Daniela, additional, Rolandsson, Olov, additional, Sacerdote, Carlotta, additional, Schulze, Matthias, additional, Gonzalez-Martin, Jon Ander, additional, Guevara, Marcela, additional, Nilsson, Peter M., additional, Panico, Salvatore, additional, Winkvist, Anna, additional, and Conklin, Annalijn, additional

Published
2023
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5. Metabolic perturbations prior to hepatocellular carcinoma diagnosis : findings from a prospective observational cohort study

Author

Stepien, Magdalena, Keski-Rahkonen, Pekka, Kiss, Agneta, Robinot, Nivonirina, Duarte-Salles, Talita, Murphy, Neil, Perlemuter, Gabriel, Viallon, Vivian, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Dahm, Christina C., Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahannat-Saleh, Yahya, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Karakatsani, Anna, Panico, Salvatore, Tumino, Rosario, Palli, Domenico, Tagliabue, Giovanna, Naccarati, Alessio, Vermeulen, Roel C. H., Bueno-de-Mesquita, Hendrik Bastiaan, Weiderpass, Elisabete, Skeie, Guri, Ramón Quirós, Jose, Ardanaz, Eva, Mokoroa, Olatz, Sala, Núria, Sánchez, Maria-Jose, María Huerta, José, Winkvist, Anna, Harlid, Sophia, Ohlsson, Bodil, Sjöberg, Klas, Schmidt, Julie A., Wareham, Nick, Khaw, Kay-Tee, Ferrari, Pietro, Rothwell, Joseph A., Gunter, Marc, Riboli, Elio, Scalbert, Augustin, Jenab, Mazda, Stepien, Magdalena, Keski-Rahkonen, Pekka, Kiss, Agneta, Robinot, Nivonirina, Duarte-Salles, Talita, Murphy, Neil, Perlemuter, Gabriel, Viallon, Vivian, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Dahm, Christina C., Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahannat-Saleh, Yahya, Aleksandrova, Krasimira, Kaaks, Rudolf, Kühn, Tilman, Trichopoulou, Antonia, Karakatsani, Anna, Panico, Salvatore, Tumino, Rosario, Palli, Domenico, Tagliabue, Giovanna, Naccarati, Alessio, Vermeulen, Roel C. H., Bueno-de-Mesquita, Hendrik Bastiaan, Weiderpass, Elisabete, Skeie, Guri, Ramón Quirós, Jose, Ardanaz, Eva, Mokoroa, Olatz, Sala, Núria, Sánchez, Maria-Jose, María Huerta, José, Winkvist, Anna, Harlid, Sophia, Ohlsson, Bodil, Sjöberg, Klas, Schmidt, Julie A., Wareham, Nick, Khaw, Kay-Tee, Ferrari, Pietro, Rothwell, Joseph A., Gunter, Marc, Riboli, Elio, Scalbert, Augustin, and Jenab, Mazda

Abstract

Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose serum concentrations are associated with HCC development, using biological samples from within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (>520 000 participants), where we identified 129 HCC cases matched 1:1 to controls. We conducted high-resolution untargeted liquid chromatography-mass spectrometry-based metabolomics on serum samples collected at recruitment prior to cancer diagnosis. Multivariable conditional logistic regression was applied controlling for dietary habits, alcohol consumption, smoking, body size, hepatitis infection and liver dysfunction. Corrections for multiple comparisons were applied. Of 9206 molecular features detected, 220 discriminated HCC cases from controls. Detailed feature annotation revealed 92 metabolites associated with HCC risk, of which 14 were unambiguously identified using pure reference standards. Positive HCC-risk associations were observed forN1-acetylspermidine, isatin,p-hydroxyphenyllactic acid, tyrosine, sphingosine,l,l-cyclo(leucylprolyl), glycochenodeoxycholic acid, glycocholic acid and 7-methylguanine. Inverse risk associations were observed for retinol, dehydroepiandrosterone sulfate, glycerophosphocholine, gamma-carboxyethyl hydroxychroman and creatine. Discernible differences for these metabolites were observed between cases and controls up to 10 years prior to diagnosis. Our observations highlight the diversity of metabolic perturbations involved in HCC development and replicate previous observations (metabolism of bile acids, amino acids and phospholipids) made in Asian and Scandinavian populations. These findings emphasize the role of metabolic pathways

Published
2021
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6. Comparing Calculated Nutrient Intakes Using Different Food Composition Databases: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort

Author

Van Puyvelde, Heleen, primary, Perez-Cornago, Aurora, additional, Casagrande, Corinne, additional, Nicolas, Geneviève, additional, Versele, Vickà, additional, Skeie, Guri, additional, B. Schulze, Matthias, additional, Johansson, Ingegerd, additional, María Huerta, José, additional, Oliverio, Andreina, additional, Ricceri, Fulvio, additional, Halkjær, Jytte, additional, Amiano Etxezarreta, Pilar, additional, Van Herck, Koen, additional, Weiderpass, Elisabete, additional, J. Gunter, Marc, additional, and Huybrechts, Inge, additional

Published
2020
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7. Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Author

MS MDL 1, CMM Groep Burgering, Epidemiology & Health Economics, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team A, Papadimitriou, Nikos, Dimou, Niki, Tsilidis, Konstantinos K, Banbury, Barbara, Martin, Richard M, Lewis, Sarah J, Kazmi, Nabila, Robinson, Timothy M, Albanes, Demetrius, Aleksandrova, Krasimira, Berndt, Sonja I, Timothy Bishop, D, Brenner, Hermann, Buchanan, Daniel D, Bueno-de-Mesquita, Bas, Campbell, Peter T, Castellví-Bel, Sergi, Chan, Andrew T, Chang-Claude, Jenny, Ellingjord-Dale, Merete, Figueiredo, Jane C, Gallinger, Steven J, Giles, Graham G, Giovannucci, Edward, Gruber, Stephen B, Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harlid, Sophia, Harrison, Tabitha A, Hoffmeister, Michael, Hopper, John L, Hsu, Li, María Huerta, José, Huyghe, Jeroen R, Jenkins, Mark A, Keku, Temitope O, Kühn, Tilman, La Vecchia, Carlo, Le Marchand, Loic, Li, Christopher I, Li, Li, Lindblom, Annika, Lindor, Noralane M, Lynch, Brigid, Markowitz, Sanford D, Masala, Giovanna, May, Anne M, Milne, Roger, Monninkhof, Evelyn, Moreno, Lorena, Moreno, Victor, Newcomb, Polly A, Offit, Kenneth, Perduca, Vittorio, Pharoah, Paul D P, Platz, Elizabeth A, Potter, John D, Rennert, Gad, Riboli, Elio, Sánchez, Maria-Jose, Schmit, Stephanie L, Schoen, Robert E, Severi, Gianluca, Sieri, Sabina, Slattery, Martha L, Song, Mingyang, Tangen, Catherine M, Thibodeau, Stephen N, Travis, Ruth C, Trichopoulou, Antonia, Ulrich, Cornelia M, van Duijnhoven, Franzel J B, Van Guelpen, Bethany, Vodicka, Pavel, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Peters, Ulrike, Gunter, Marc J, Murphy, Neil, MS MDL 1, CMM Groep Burgering, Epidemiology & Health Economics, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team A, Papadimitriou, Nikos, Dimou, Niki, Tsilidis, Konstantinos K, Banbury, Barbara, Martin, Richard M, Lewis, Sarah J, Kazmi, Nabila, Robinson, Timothy M, Albanes, Demetrius, Aleksandrova, Krasimira, Berndt, Sonja I, Timothy Bishop, D, Brenner, Hermann, Buchanan, Daniel D, Bueno-de-Mesquita, Bas, Campbell, Peter T, Castellví-Bel, Sergi, Chan, Andrew T, Chang-Claude, Jenny, Ellingjord-Dale, Merete, Figueiredo, Jane C, Gallinger, Steven J, Giles, Graham G, Giovannucci, Edward, Gruber, Stephen B, Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harlid, Sophia, Harrison, Tabitha A, Hoffmeister, Michael, Hopper, John L, Hsu, Li, María Huerta, José, Huyghe, Jeroen R, Jenkins, Mark A, Keku, Temitope O, Kühn, Tilman, La Vecchia, Carlo, Le Marchand, Loic, Li, Christopher I, Li, Li, Lindblom, Annika, Lindor, Noralane M, Lynch, Brigid, Markowitz, Sanford D, Masala, Giovanna, May, Anne M, Milne, Roger, Monninkhof, Evelyn, Moreno, Lorena, Moreno, Victor, Newcomb, Polly A, Offit, Kenneth, Perduca, Vittorio, Pharoah, Paul D P, Platz, Elizabeth A, Potter, John D, Rennert, Gad, Riboli, Elio, Sánchez, Maria-Jose, Schmit, Stephanie L, Schoen, Robert E, Severi, Gianluca, Sieri, Sabina, Slattery, Martha L, Song, Mingyang, Tangen, Catherine M, Thibodeau, Stephen N, Travis, Ruth C, Trichopoulou, Antonia, Ulrich, Cornelia M, van Duijnhoven, Franzel J B, Van Guelpen, Bethany, Vodicka, Pavel, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Peters, Ulrike, Gunter, Marc J, and Murphy, Neil

Published
2020

8. A prospective evaluation of plasma polyphenol levels and colon cancer risk

Author

Murphy, Neil, primary, Achaintre, David, additional, Zamora‐Ros, Raul, additional, Jenab, Mazda, additional, Boutron‐Ruault, Marie‐Christine, additional, Carbonnel, Franck, additional, Savoye, Isabelle, additional, Kaaks, Rudolf, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Aleksandrova, Krasimira, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Overvad, Kim, additional, Quirós, J. Ramón, additional, Sánchez, Maria‐Jose, additional, Altzibar, Jone M., additional, María Huerta, José, additional, Barricarte, Aurelio, additional, Khaw, Kay‐Tee, additional, Bradbury, Kathryn E., additional, Perez‐Cornago, Aurora, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Peppa, Eleni, additional, Palli, Domenico, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Panico, Salvatore, additional, Bueno‐de‐Mesquita, H. B(as), additional, Peeters, Petra H., additional, Rutegård, Martin, additional, Johansson, Ingegerd, additional, Freisling, Heinz, additional, Noh, Hwayoung, additional, Cross, Amanda J., additional, Vineis, Paolo, additional, Tsilidis, Kostas, additional, Gunter, Marc J., additional, and Scalbert, Augustin, additional

Published
2018
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9. Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence : analysis within EPIC-InterAct across eight European countries

Author

Li, Sherly X., Imamura, Fumiaki, Schulze, Matthias B., Zheng, Jusheng, Ye, Zheng, Agudo, Antonio, Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner, Dorronsoro, Miren, Dow, Courtney, Fagherazzi, Guy, Grioni, Sara, Gunter, Marc J., María Huerta, José, Ibsen, Daniel B., Jakobsen, Marianne Uhre, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay-Tee, Kyrø, Cecilie, Mancini, Francesca Romana, Molina-Portillo, Elena, Murphy, Neil, Nilsson, Peter M., Onland-Moret, N. Charlotte, Palli, Domenico, Panico, Salvatore, Poveda, Alaitz, Ramón Quirós, J., Ricceri, Fulvio, Sluijs, Ivonne, Spijkerman, Annemieke M. W., Tjonneland, Anne, Tumino, Rosario, Winkvist, Anna, Langenberg, Claudia, Sharp, Stephen J., Riboli, Elio, Scott, Robert A., Forouhi, Nita G., Wareham, Nicholas J., Li, Sherly X., Imamura, Fumiaki, Schulze, Matthias B., Zheng, Jusheng, Ye, Zheng, Agudo, Antonio, Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner, Dorronsoro, Miren, Dow, Courtney, Fagherazzi, Guy, Grioni, Sara, Gunter, Marc J., María Huerta, José, Ibsen, Daniel B., Jakobsen, Marianne Uhre, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay-Tee, Kyrø, Cecilie, Mancini, Francesca Romana, Molina-Portillo, Elena, Murphy, Neil, Nilsson, Peter M., Onland-Moret, N. Charlotte, Palli, Domenico, Panico, Salvatore, Poveda, Alaitz, Ramón Quirós, J., Ricceri, Fulvio, Sluijs, Ivonne, Spijkerman, Annemieke M. W., Tjonneland, Anne, Tumino, Rosario, Winkvist, Anna, Langenberg, Claudia, Sharp, Stephen J., Riboli, Elio, Scott, Robert A., Forouhi, Nita G., and Wareham, Nicholas J.

Abstract

Aims/hypothesis: Gene-macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes by investigating potential interactions between genes and macronutrient intake and their association with the incidence of type 2 diabetes. Methods: We investigated the influence of interactions between genetic risk scores (GRSs) for type 2 diabetes, insulin resistance and BMI and macronutrient intake on the development of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a prospective case-cohort study across eight European countries (N = 21,900 with 9742 incident type 2 diabetes cases). Macronutrient intake was estimated from diets reported in questionnaires, including proportion of energy derived from total carbohydrate, protein, fat, plant and animal protein, saturated, monounsaturated and polyunsaturated fat and dietary fibre. Using multivariable-adjusted Cox regression, we estimated country-specific interaction results on the multiplicative scale, using random-effects meta-analysis. Secondary analysis used isocaloric macronutrient substitution. Results: No interactions were identified between any of the three GRSs and any macronutrient intake, with low-to-moderate heterogeneity between countries (I-2 range 0-51.6%). Results were similar using isocaloric macronutrient substitution analyses and when weighted and unweighted GRSs and individual SNPs were examined. Conclusions/interpretation: Genetic susceptibility to type 2 diabetes, insulin resistance and BMI did not modify the association between macronutrient intake and incident type 2 diabetes. This suggests that macronutrient intake recommendations to prevent type 2 diabetes do not need to account for differences in genetic predisposition to these three metabolic conditions.

Published
2018
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10. A prospective evaluation of plasma polyphenol levels and colon cancer risk

Author

Murphy, Neil, Achaintre, David, Zamora-Ros, Raul, Jenab, Mazda, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Savoye, Isabelle, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Quirós, J Ramón, Sánchez, Maria-Jose, Altzibar, Jone M, María Huerta, José, Barricarte, Aurelio, Khaw, Kay-Tee, Bradbury, Kathryn E, Perez-Cornago, Aurora, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H B As, Peeters, Petra H, Rutegård, Martin, Johansson, Ingegerd, Freisling, Heinz, Noh, Hwayoung, Cross, Amanda J, Vineis, Paolo, Tsilidis, Kostas, Gunter, Marc J, Scalbert, Augustin, Murphy, Neil, Achaintre, David, Zamora-Ros, Raul, Jenab, Mazda, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Savoye, Isabelle, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Quirós, J Ramón, Sánchez, Maria-Jose, Altzibar, Jone M, María Huerta, José, Barricarte, Aurelio, Khaw, Kay-Tee, Bradbury, Kathryn E, Perez-Cornago, Aurora, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H B As, Peeters, Petra H, Rutegård, Martin, Johansson, Ingegerd, Freisling, Heinz, Noh, Hwayoung, Cross, Amanda J, Vineis, Paolo, Tsilidis, Kostas, Gunter, Marc J, and Scalbert, Augustin

Abstract

Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95% CI] = 0.79-0.93; qvalue = 0.01) and homovanillic acid (OR per log2 -value, 1.46, 95% CI = 1.16-1.84; qvalue = 0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR = 0.61, 95% CI = 0.41-0.91, ptrend = 0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR = 1.72, 95% CI = 1.17-2.53, ptrend < 0.0001). No heterogeneity for these associations was observed by sex and across other colon cancer risk factors. The remaining polyphenols were not associated with colon cancer risk. Higher equol concentrations were associated with lower risk, and higher homovanillic acid concentrations were associated with greater risk of colon cancer. These findings support a potential role for specific polyphenols in colon tumorigenesis.

Published
2018
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11. A prospective evaluation of plasma polyphenol levels and colon cancer risk

Author

Epi Methoden Team 3, UMC Utrecht, Julius Centrum, Cancer, JC onderzoeksprogramma Kanker, Murphy, Neil, Achaintre, David, Zamora-Ros, Raul, Jenab, Mazda, Boutron-Ruault, Marie Christine, Carbonnel, Franck, Savoye, Isabelle, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Quirós, J. Ramón, Sánchez, Maria Jose, Altzibar, Jone M., María Huerta, José, Barricarte, Aurelio, Khaw, Kay Tee, Bradbury, Kathryn E., Perez-Cornago, Aurora, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H. B(as), Peeters, Petra H., Rutegård, Martin, Johansson, Ingegerd, Freisling, Heinz, Noh, Hwayoung, Cross, Amanda J., Vineis, Paolo, Tsilidis, Kostas, Gunter, Marc J., Scalbert, Augustin, Epi Methoden Team 3, UMC Utrecht, Julius Centrum, Cancer, JC onderzoeksprogramma Kanker, Murphy, Neil, Achaintre, David, Zamora-Ros, Raul, Jenab, Mazda, Boutron-Ruault, Marie Christine, Carbonnel, Franck, Savoye, Isabelle, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Quirós, J. Ramón, Sánchez, Maria Jose, Altzibar, Jone M., María Huerta, José, Barricarte, Aurelio, Khaw, Kay Tee, Bradbury, Kathryn E., Perez-Cornago, Aurora, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H. B(as), Peeters, Petra H., Rutegård, Martin, Johansson, Ingegerd, Freisling, Heinz, Noh, Hwayoung, Cross, Amanda J., Vineis, Paolo, Tsilidis, Kostas, Gunter, Marc J., and Scalbert, Augustin

Published
2018

12. Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries : a cross-sectional analysis in the EPIC-InterAct study

Author

Zheng, Ju-Sheng, Sharp, Stephen J., Imamura, Fumiaki, Koulman, Albert, Schulze, Matthias B., Ye, Zheng, Griffin, Jules, Guevara, Marcela, María Huerta, José, Kröger, Janine, Sluijs, Ivonne, Agudo, Antonio, Barricarte, Aurelio, Boeing, Heiner, Colorado-Yohar, Sandra, Dow, Courtney, Dorronsoro, Miren, Dinesen, Pia T., Fagherazzi, Guy, Franks, Paul W., Feskens, Edith J. M., Kühn, Tilman, Katzke, Verena Andrea, Key, Timothy J., Khaw, Kay-Tee, de Magistris, Maria Santucci, Romana Mancini, Francesca, Molina-Portillo, Elena, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Ramón Quirós, Jose, Rolandsson, Olov, Ricceri, Fulvio, Spijkerman, Annemieke M. W., Slimani, Nadia, Tagliabue, Giovanna, Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Langenberg, Claudia, Riboli, Elio, Forouhi, Nita G., Wareham, Nicholas J., Zheng, Ju-Sheng, Sharp, Stephen J., Imamura, Fumiaki, Koulman, Albert, Schulze, Matthias B., Ye, Zheng, Griffin, Jules, Guevara, Marcela, María Huerta, José, Kröger, Janine, Sluijs, Ivonne, Agudo, Antonio, Barricarte, Aurelio, Boeing, Heiner, Colorado-Yohar, Sandra, Dow, Courtney, Dorronsoro, Miren, Dinesen, Pia T., Fagherazzi, Guy, Franks, Paul W., Feskens, Edith J. M., Kühn, Tilman, Katzke, Verena Andrea, Key, Timothy J., Khaw, Kay-Tee, de Magistris, Maria Santucci, Romana Mancini, Francesca, Molina-Portillo, Elena, Nilsson, Peter M., Olsen, Anja, Overvad, Kim, Palli, Domenico, Ramón Quirós, Jose, Rolandsson, Olov, Ricceri, Fulvio, Spijkerman, Annemieke M. W., Slimani, Nadia, Tagliabue, Giovanna, Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Langenberg, Claudia, Riboli, Elio, Forouhi, Nita G., and Wareham, Nicholas J.

Abstract

Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. Methods: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested. Results: Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption. Conclusions: Subtypes

Published
2017
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13. Alcoholic Beverage Preference and Dietary Habits in Elderly across Europe : Analyses within the Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES) Project

Author

Sluik, Diewertje, Jankovic, Nicole, O'Doherty, Mark G., Geelen, Anouk, Schöttker, Ben, Rolandsson, Olov, Kiefte-de Jong, Jessica C., Ferrieres, Jean, Bamia, Christina, Fransen, Heidi P., Boer, Jolanda M. A., Eriksson, Sture, Martinez, Begoña, María Huerta, José, Kromhout, Daan, de Groot, Lisette C. P. G. M., Franco, Oscar H., Trichopoulou, Antonia, Boffetta, Paolo, Kee, Frank, Feskens, Edith J. M., Sluik, Diewertje, Jankovic, Nicole, O'Doherty, Mark G., Geelen, Anouk, Schöttker, Ben, Rolandsson, Olov, Kiefte-de Jong, Jessica C., Ferrieres, Jean, Bamia, Christina, Fransen, Heidi P., Boer, Jolanda M. A., Eriksson, Sture, Martinez, Begoña, María Huerta, José, Kromhout, Daan, de Groot, Lisette C. P. G. M., Franco, Oscar H., Trichopoulou, Antonia, Boffetta, Paolo, Kee, Frank, and Feskens, Edith J. M.

Abstract

Introduction: The differential associations of beer, wine, and spirit consumption on cardiovascular risk found in observational studies may be confounded by diet. We described and compared dietary intake and diet quality according to alcoholic beverage preference in European elderly. Methods: From the Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES), seven European cohorts were included, i.e. four sub-cohorts from EPIC-Elderly, the SENECA Study, the Zutphen Elderly Study, and the Rotterdam Study. Harmonized data of 29,423 elderly participants from 14 European countries were analyzed. Baseline data on consumption of beer, wine, and spirits, and dietary intake were collected with questionnaires. Diet quality was assessed using the Healthy Diet Indicator (HDI). Intakes and scores across categories of alcoholic beverage preference (beer, wine, spirit, no preference, non-consumers) were adjusted for age, sex, socio-economic status, self-reported prevalent diseases, and lifestyle factors. Cohort-specific mean intakes and scores were calculated as well as weighted means combining all cohorts. Results: In 5 of 7 cohorts, persons with a wine preference formed the largest group. After multivariate adjustment, persons with a wine preference tended to have a higher HDI score and intake of healthy foods in most cohorts, but differences were small. The weighted estimates of all cohorts combined revealed that non-consumers had the highest fruit and vegetable intake, followed by wine consumers. Non-consumers and persons with no specific preference had a higher HDI score, spirit consumers the lowest. However, overall diet quality as measured by HDI did not differ greatly across alcoholic beverage preference categories. Discussion: This study using harmonized data from ~30,000 elderly from 14 European countries showed that, after multivariate adjustment, dietary habits and diet quality did not differ greatly according to alcoholic beverage

Published
2016
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14. Circulating Fetuin-A and Risk of Type 2 Diabetes: A Mendelian Randomization Analysis.

Author

Kröger, Janine, Meidtner, Karina, Stefan, Norbert, Guevara, Marcela, Kerrison, Nicola D., Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner, Dorronsoro, Miren, Dow, Courtney, Fagherazzi, Guy, Franks, Paul W., Freisling, Heinz, Gunter, Marc J., María Huerta, José, Kaaks, Rudolf, Key, Timothy J., Kay Tee Khaw, Krogh, Vittorio, and Kühn, Tilman

Abstract

Fetuin-A, a hepatic-origin protein, is strongly positively associated with risk of type 2 diabetes in human observational studies, but it is unknown whether this association is causal. We aimed to study the potential causal relation of circulating fetuin-A to risk of type 2 diabetes in a Mendelian randomization study with single nucleotide polymorphisms located in the fetuin-A-encoding AHSG gene. We used data from eight European countries of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study including 10,020 incident cases. Plasma fetuin-A concentration was measured in a subset of 965 subcohort participants and 654 case subjects. A genetic score of the AHSG single nucleotide polymorphisms was strongly associated with fetuin-A (28% explained variation). Using the genetic score as instrumental variable of fetuin-A, we observed no significant association of a 50 µg/mL higher fetuin-A concentration with diabetes risk (hazard ratio 1.02 [95% CI 0.97, 1.07]). Combining our results with those from the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) consortium (12,171 case subjects) also did not suggest a clear significant relation of fetuin-A with diabetes risk. In conclusion, although there is mechanistic evidence for an effect of fetuin-A on insulin sensitivity and secretion, this study does not support a strong, relevant relationship between circulating fetuin-A and diabetes risk in the general population. [ABSTRACT FROM AUTHOR]

Published
2018
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15. Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition.

Author

Leenders, Max, Leufkens, Anke M, Siersema, Peter D, van Duijnhoven, Fränzel J B, Vrieling, Alina, Hulshof, Paul J M, van Gils, Carla H, Overvad, Kim, Roswall, Nina, Kyrø, Cecilie, Boutron-Ruault, Marie-Christine, Fagerhazzi, Guy, Cadeau, Claire, Kühn, Tilman, Johnson, Theron, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Klinaki, Eleni, Androulidaki, Anna, Palli, Domenico, Grioni, Sara, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Bakker, Marije F, Skeie, Guri, Weiderpass, Elisabete, Jakszyn, Paula, Barricarte, Aurelio, María Huerta, José, Molina-Montes, Esther, Argüelles, Marcial, Johansson, Ingegerd, Ljuslinder, Ingrid, Key, Timothy J, Bradbury, Kathryn E, Khaw, Kay-Tee, Wareham, Nicholas J, Ferrari, Pietro, Duarte-Salles, Talita, Jenab, Mazda, Gunter, Marc J, Vergnaud, Anne-Claire, Wark, Petra A, Bueno-de-Mesquita, H B As, Leenders, Max, Leufkens, Anke M, Siersema, Peter D, van Duijnhoven, Fränzel J B, Vrieling, Alina, Hulshof, Paul J M, van Gils, Carla H, Overvad, Kim, Roswall, Nina, Kyrø, Cecilie, Boutron-Ruault, Marie-Christine, Fagerhazzi, Guy, Cadeau, Claire, Kühn, Tilman, Johnson, Theron, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Klinaki, Eleni, Androulidaki, Anna, Palli, Domenico, Grioni, Sara, Sacerdote, Carlotta, Tumino, Rosario, Panico, Salvatore, Bakker, Marije F, Skeie, Guri, Weiderpass, Elisabete, Jakszyn, Paula, Barricarte, Aurelio, María Huerta, José, Molina-Montes, Esther, Argüelles, Marcial, Johansson, Ingegerd, Ljuslinder, Ingrid, Key, Timothy J, Bradbury, Kathryn E, Khaw, Kay-Tee, Wareham, Nicholas J, Ferrari, Pietro, Duarte-Salles, Talita, Jenab, Mazda, Gunter, Marc J, Vergnaud, Anne-Claire, Wark, Petra A, and Bueno-de-Mesquita, H B As

Abstract

Carotenoids and vitamins A, C and E are possibly associated with a reduced colorectal cancer (CRC) risk through antioxidative properties. The association of prediagnostic plasma concentrations and dietary consumption of carotenoids and vitamins A, C and E with the risk of colon and rectal cancer was examined in this case-control study, nested within the European Prospective Investigation into Cancer and Nutrition study. Plasma concentrations of carotenoids (α- and β-carotene, canthaxanthin, β-cryptoxanthin, lutein, lycopene, zeaxanthin) and vitamins A (retinol), C and E (α-, β- and γ- and δ-tocopherol) and dietary consumption of β-carotene and vitamins A, C and E were determined in 898 colon cancer cases, 501 rectal cancer cases and 1,399 matched controls. Multivariable conditional logistic regression models were performed to estimate incidence rate ratios (IRR) and corresponding 95% confidence intervals (CIs). An association was observed between higher prediagnostic plasma retinol concentration and a lower risk of colon cancer (IRR for highest quartile = 0.63, 95% CI: 0.46, 0.87, p for trend = 0.01), most notably proximal colon cancer (IRR for highest quartile = 0.46, 95% CI: 0.27, 0.77, p for trend = 0.01). Additionally, inverse associations for dietary β-carotene and dietary vitamins C and E with (distal) colon cancer were observed. Although other associations were suggested, there seems little evidence for a role of these selected compounds in preventing CRC through their antioxidative properties.

Published
2014
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16. Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition

Author

Leenders, Max, primary, Leufkens, Anke M., additional, Siersema, Peter D., additional, van Duijnhoven, Fränzel J.B., additional, Vrieling, Alina, additional, Hulshof, Paul J.M., additional, van Gils, Carla H., additional, Overvad, Kim, additional, Roswall, Nina, additional, Kyrø, Cecilie, additional, Boutron-Ruault, Marie-Christine, additional, Fagerhazzi, Guy, additional, Cadeau, Claire, additional, Kühn, Tilman, additional, Johnson, Theron, additional, Boeing, Heiner, additional, Aleksandrova, Krasimira, additional, Trichopoulou, Antonia, additional, Klinaki, Eleni, additional, Androulidaki, Anna, additional, Palli, Domenico, additional, Grioni, Sara, additional, Sacerdote, Carlotta, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Bakker, Marije F., additional, Skeie, Guri, additional, Weiderpass, Elisabete, additional, Jakszyn, Paula, additional, Barricarte, Aurelio, additional, María Huerta, José, additional, Molina-Montes, Esther, additional, Argüelles, Marcial, additional, Johansson, Ingegerd, additional, Ljuslinder, Ingrid, additional, Key, Timothy J., additional, Bradbury, Kathryn E., additional, Khaw, Kay-Tee, additional, Wareham, Nicholas J., additional, Ferrari, Pietro, additional, Duarte-Salles, Talita, additional, Jenab, Mazda, additional, Gunter, Marc J., additional, Vergnaud, Anne-Claire, additional, Wark, Petra A., additional, and Bueno-de-Mesquita, H. Bas, additional

Published
2014
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17. Dietary Flavonoid and Lignan Intake and Mortality in a Spanish Cohort

Author

Zamora-Ros, Raul, primary, Jiménez, Carolina, additional, Cleries, Ramón, additional, Agudo, Antonio, additional, Sánchez, María-José, additional, Sánchez-Cantalejo, Emilio, additional, Molina-Montes, Esther, additional, Navarro, Carmen, additional, Chirlaque, María-Dolores, additional, María Huerta, José, additional, Amiano, Pilar, additional, Redondo, M. Luisa, additional, Barricarte, Aurelio, additional, and González, Carlos A., additional

Published
2013
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18. Differences in dietary intakes, food sources and determinants of total flavonoids between Mediterranean and non-Mediterranean countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, primary, Knaze, Viktoria, additional, Luján-Barroso, Leila, additional, Romieu, Isabelle, additional, Scalbert, Augustin, additional, Slimani, Nadia, additional, Hjartåker, Anette, additional, Engeset, Dagrun, additional, Skeie, Guri, additional, Overvad, Kim, additional, Bredsdorff, Lea, additional, Tjønneland, Anne, additional, Halkjær, Jytte, additional, Key, Timothy J., additional, Khaw, Kay-Tee, additional, Mulligan, Angela A., additional, Winkvist, Anna, additional, Johansson, Ingegerd, additional, Bueno-de-Mesquita, H. Bas, additional, Peeters, Petra H. M., additional, Wallström, Peter, additional, Ericson, Ulrika, additional, Pala, Valeria, additional, de Magistris, Maria Santucci, additional, Polidoro, Silvia, additional, Tumino, Rosario, additional, Trichopoulou, Antonia, additional, Dilis, Vardis, additional, Katsoulis, Michael, additional, María Huerta, José, additional, Martínez, Virginia, additional, Sánchez, María-José, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Teucher, Birgit, additional, Grote, Verena, additional, Bendinelli, Benedetta, additional, Boeing, Heiner, additional, Förster, Jana, additional, Touillaud, Marina, additional, Perquier, Florence, additional, Fagherazzi, Guy, additional, Gallo, Valentina, additional, Riboli, Elio, additional, and González, Carlos A., additional

Published
2012
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19. Comparison of standardised dietary folate intake across ten countries participating in the European Prospective Investigation into Cancer and Nutrition

Author

Park, Jin Young, primary, Nicolas, Genevieve, additional, Freisling, Heinz, additional, Biessy, Carine, additional, Scalbert, Augustin, additional, Romieu, Isabelle, additional, Chajès, Véronique, additional, Chuang, Shu-Chun, additional, Ericson, Ulrika, additional, Wallström, Peter, additional, Ros, Martine M., additional, Peeters, Petra H. M., additional, Mattiello, Amalia, additional, Palli, Domenico, additional, María Huerta, José, additional, Amiano, Pilar, additional, Halkjær, Jytte, additional, Dahm, Christina C., additional, Trichopoulou, Antonia, additional, Orfanos, Philippos, additional, Teucher, Birgit, additional, Feller, Silke, additional, Skeie, Guri, additional, Engeset, Dagrun, additional, Boutron-Ruault, Marie-Christine, additional, Clavel-Chapelon, Françoise, additional, Crowe, Francesca, additional, Khaw, Kay-Tee, additional, Vineis, Paolo, additional, and Slimani, Nadia, additional

Published
2011
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20. Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort

Author

Zamora-Ros, Raul, primary, Knaze, Viktoria, additional, Luján-Barroso, Leila, additional, Slimani, Nadia, additional, Romieu, Isabelle, additional, Fedirko, Veronika, additional, Santucci de Magistris, Maria, additional, Ericson, Ulrica, additional, Amiano, Pilar, additional, Trichopoulou, Antonia, additional, Dilis, Vardis, additional, Naska, Androniki, additional, Engeset, Dagrun, additional, Skeie, Guri, additional, Cassidy, Aedin, additional, Overvad, Kim, additional, Peeters, Petra H. M., additional, María Huerta, José, additional, Sánchez, María-José, additional, Quirós, J. Ramón, additional, Sacerdote, Carlotta, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Johansson, Gerd, additional, Johansson, Ingegerd, additional, Drake, Isabel, additional, Crowe, Francesca L., additional, Barricarte, Aurelio, additional, Kaaks, Rudolf, additional, Teucher, Birgit, additional, Bas Bueno-de-Mesquita, H., additional, van Rossum, Caroline T. M., additional, Norat, Teresa, additional, Romaguera, Dora, additional, Vergnaud, Anne-Claire, additional, Tjønneland, Anne, additional, Halkjær, Jytte, additional, Clavel-Chapelon, Françoise, additional, Boutron-Ruault, Marie-Christine, additional, Touillaud, Marina, additional, Salvini, Simonetta, additional, Khaw, Kay-Thee, additional, Wareham, Nicholas, additional, Boeing, Heiner, additional, Förster, Jana, additional, Riboli, Elio, additional, and González, Carlos A., additional

Published
2011
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21. Adherence to the Mediterranean diet reduces mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain)

Author

Buckland, Genevieve, primary, Agudo, Antonio, additional, Travier, Noemie, additional, María Huerta, José, additional, Cirera, Lluís, additional, Tormo, María-José, additional, Navarro, Carmen, additional, Dolores Chirlaque, María, additional, Moreno-Iribas, Conchi, additional, Ardanaz, Eva, additional, Barricarte, Aurelio, additional, Etxeberria, Jaione, additional, Marin, Pilar, additional, Ramón Quirós, J., additional, Redondo, María-Luisa, additional, Larrañaga, Nerea, additional, Amiano, Pilar, additional, Dorronsoro, Miren, additional, Arriola, Larraitz, additional, Basterretxea, Mikel, additional, Sanchez, María-José, additional, Molina, Esther, additional, and González, Carlos A., additional

Published
2011
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22. Comparison of standardised dietary folate intake across ten countries participating in the European Prospective Investigation into Cancer and Nutrition.

Author

Park, Jin Young, Nicolas, Genevieve, Freisling, Heinz, Biessy, Carine, Scalbert, Augustin, Romieu, Isabelle, Chajès, Véronique, Chuang, Shu-Chun, Ericson, Ulrika, Wallström, Peter, Ros, Martine M., Peeters, Petra H. M., Mattiello, Amalia, Palli, Domenico, María Huerta, José, Amiano, Pilar, Halkjær, Jytte, Dahm, Christina C., Trichopoulou, Antonia, and Orfanos, Philippos

Subjects
AUTOMATIC data collection systems, COMPARATIVE studies, DIET, FOLIC acid, INTERVIEWING, PROBABILITY theory, RESEARCH funding, SEASONS, SURVEYS, T-test (Statistics), TUMORS, LIFESTYLES, CROSS-sectional method, FOOD diaries, DATA analysis software
Abstract

Folate plays an important role in the synthesis and methylation of DNA as a cofactor in one-carbon metabolism. Inadequate folate intake has been linked to adverse health events. However, comparable information on dietary folate intake across European countries has never been reported. The objective of the present study was to describe the dietary folate intake and its food sources in ten countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cross-sectional analysis was conducted in 36 034 participants (aged 35–74 years) who completed a single 24 h dietary recall using a computerised interview software program, EPIC-Soft® (International Agency for Research on Cancer, Lyon). Dietary folate intake was estimated using the standardised EPIC Nutrient DataBase, adjusted for age, energy intake, weight and height and weighted by season and day of recall. Adjusted mean dietary folate intake in most centres ranged from 250 to 350 μg/d in men and 200 to 300 μg/d in women. Folate intake tended to be lower among current smokers and heavier alcohol drinkers and to increase with educational level, especially in women. Supplement users (any types) were likely to report higher dietary folate intake in most centres. Vegetables, cereals and fruits, nuts and seeds were the main contributors to folate intake. Nonetheless, the type and pattern of consumption of these main food items varied across the centres. These first comparisons of standardised dietary folate intakes across different European populations show moderate regional differences (except the UK health conscious group), and variation by sex, educational level, smoking and alcohol-drinking status, and supplement use. [ABSTRACT FROM PUBLISHER]

Published
2012
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23. Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Author

Papadimitriou, Nikos, Dimou, Niki, Tsilidis, Konstantinos K, Banbury, Barbara, Martin, Richard M, Lewis, Sarah J, Kazmi, Nabila, Robinson, Timothy M, Albanes, Demetrius, Aleksandrova, Krasimira, Berndt, Sonja I, Timothy Bishop, D, Brenner, Hermann, Buchanan, Daniel D, Bueno-De-Mesquita, Bas, Campbell, Peter T, Castellví-Bel, Sergi, Chan, Andrew T, Chang-Claude, Jenny, Ellingjord-Dale, Merete, Figueiredo, Jane C, Gallinger, Steven J, Giles, Graham G, Giovannucci, Edward, Gruber, Stephen B, Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harlid, Sophia, Harrison, Tabitha A, Hoffmeister, Michael, Hopper, John L, Hsu, Li, María Huerta, José, Huyghe, Jeroen R, Jenkins, Mark A, Keku, Temitope O, Kühn, Tilman, La Vecchia, Carlo, Le Marchand, Loic, Li, Christopher I, Li, Li, Lindblom, Annika, Lindor, Noralane M, Lynch, Brigid, Markowitz, Sanford D, Masala, Giovanna, May, Anne M, Milne, Roger, Monninkhof, Evelyn, Moreno, Lorena, Moreno, Victor, Newcomb, Polly A, Offit, Kenneth, Perduca, Vittorio, Pharoah, Paul DP, Platz, Elizabeth A, Potter, John D, Rennert, Gad, Riboli, Elio, Sánchez, Maria-Jose, Schmit, Stephanie L, Schoen, Robert E, Severi, Gianluca, Sieri, Sabina, Slattery, Martha L, Song, Mingyang, Tangen, Catherine M, Thibodeau, Stephen N, Travis, Ruth C, Trichopoulou, Antonia, Ulrich, Cornelia M, Van Duijnhoven, Franzel JB, Van Guelpen, Bethany, Vodicka, Pavel, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Peters, Ulrike, Gunter, Marc J, and Murphy, Neil

Subjects
Risk Factors, Accelerometry, Odds Ratio, Humans, Breast Neoplasms, Female, Genetic Predisposition to Disease, Mendelian Randomization Analysis, Colorectal Neoplasms, Exercise, Polymorphism, Single Nucleotide, 3. Good health
Abstract

Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

24. Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Author

Papadimitriou, Nikos, Dimou, Niki, Tsilidis, Konstantinos K., Banbury, Barbara, Martin, Richard M., Lewis, Sarah J., Kazmi, Nabila, Robinson, Timothy M., Albanes, Demetrius, Aleksandrova, Krasimira, Berndt, Sonja I., Timothy Bishop, D., Brenner, Hermann, Buchanan, Daniel D., Bueno-De-Mesquita, Bas, Campbell, Peter T., Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Ellingjord-Dale, Merete, Figueiredo, Jane C., Gallinger, Steven J., Giles, Graham G., Giovannucci, Edward, Gruber, Stephen B., Gsur, Andrea, Hampe, Jochen, Hampel, Heather, Harlid, Sophia, Harrison, Tabitha A., Hoffmeister, Michael, Hopper, John L., Hsu, Li, María Huerta, José, Huyghe, Jeroen R., Jenkins, Mark A., Keku, Temitope O., Kühn, Tilman, La Vecchia, Carlo, Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane M., Lynch, Brigid, Markowitz, Sanford D., Masala, Giovanna, May, Anne M., Milne, Roger, Monninkhof, Evelyn, Moreno, Lorena, Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Perduca, Vittorio, Pharoah, Paul D. P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Riboli, Elio, Sánchez, Maria-Jose, Schmit, Stephanie L., Schoen, Robert E., Severi, Gianluca, Sieri, Sabina, Slattery, Martha L., Song, Mingyang, Tangen, Catherine M., Thibodeau, Stephen N., Travis, Ruth C., Trichopoulou, Antonia, Ulrich, Cornelia M., Van Duijnhoven, Franzel J. B., Van Guelpen, Bethany, Vodicka, Pavel, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Peters, Ulrike, Gunter, Marc J., and Murphy, Neil

Subjects
631/67, 631/67/1504/1885, 141, 45, 631/67/68, article, 631/67/2324, 45/23, 631/67/1347, 3. Good health
Abstract

Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

25. A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk

Author

Aurelio Barricarte, Marc J. Gunter, Amanda J. Cross, Eleni Peppa, H. B. Bueno-De-Mesquita, Cecilie Kyrø, Augustin Scalbert, J. Ramón Quirós, Isabelle Savoye, José María Huerta, Tilman Kühn, Heiner Boeing, Marie-Christine Boutron-Ruault, Ingegerd Johansson, Salvatore Panico, Martin Rutegård, Carlotta Sacerdote, Kim Overvad, Kostas Tsilidis, Rosario Tumino, Neil Murphy, Raul Zamora-Ros, Anne Tjønneland, Mazda Jenab, Heinz Freisling, Hwayoung Noh, Aurora Perez-Cornago, María José Sánchez, Franck Carbonnel, Antonia Trichopoulou, David Achaintre, Paolo Vineis, Jone M. Altzibar, Kathryn E. Bradbury, Krasimira Aleksandrova, Sara Grioni, Petra H.M. Peeters, Rudolf Kaaks, Anna Karakatsani, Domenico Palli, Kay-Tee Khaw, Murphy, Neil, Achaintre, David, Zamora-Ros, Raul, Jenab, Mazda, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Savoye, Isabelle, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Quirós, J Ramón, Sánchez, Maria-Jose, Altzibar, Jone M, María Huerta, José, Barricarte, Aurelio, Khaw, Kay-Tee, Bradbury, Kathryn E, Perez-Cornago, Aurora, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H B A, Peeters, Petra H, Rutegård, Martin, Johansson, Ingegerd, Freisling, Heinz, Noh, Hwayoung, Cross, Amanda J, Vineis, Paolo, Tsilidis, Kosta, Gunter, Marc J, and Scalbert, Augustin

Subjects
0301 basic medicine, Oncology, Male, Cancer Research, Colorectal cancer, Prospective evaluation, COLORECTAL-CANCER, Body Mass Index, EPIC COHORT, Prostate cancer, chemistry.chemical_compound, 0302 clinical medicine, nested case-control study, Risk Factors, Prospective Studies, Biochemical markers, food and beverages, Biological activity, Equol, Middle Aged, Prognosis, PROSTATE-CANCER, Estudi de casos, colon cancer, 030220 oncology & carcinogenesis, Polifenols, Colonic Neoplasms, Marcadors bioquímics, biomarker, NUTRITION, Female, Life Sciences & Biomedicine, EQUOL, Cancer Epidemiology, FLAVONOID INTAKE, medicine.medical_specialty, ESTROGEN-RECEPTOR-BETA, PHENOL-EXPLORER DATABASE, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Càncer colorectal, Internal medicine, SYSTEMATIC ANALYSIS, medicine, Biomarkers, Tumor, Humans, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, METAANALYSIS, Estrogen receptor beta, polyphenols, Cancer och onkologi, Science & Technology, business.industry, biomarkers, nested case–control study, medicine.disease, digestive system diseases, 030104 developmental biology, chemistry, Polyphenol, Case-Control Studies, Cancer and Oncology, Nested case-control study, Case studies, business, EPIC, Follow-Up Studies
Abstract

Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre‐diagnostic plasma polyphenols and colon cancer risk in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (q values) was computed to control for multiple comparisons. All statistical tests were two‐sided. After false discovery rate correction and in continuous log2‐transformed multivariable models, equol (odds ratio [OR] per log2‐value, 0.86, 95% confidence interval [95% CI] = 0.79–0.93; q value = 0.01) and homovanillic acid (OR per log2‐value, 1.46, 95% CI = 1.16–1.84; q value = 0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR = 0.61, 95% CI = 0.41–0.91, p trend = 0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR = 1.72, 95% CI = 1.17–2.53, p trend, What's new? Polyphenols are antioxidants abundant in food, and some polyphenols have demonstrated an anti‐cancer effect. Here, the authors looked for an association between polyphenols and colon cancer risk by conducting a nested case–control analysis within the EPIC cohort. Rather than employing questionnaires that rely on participant memories of their diet, this study directly measured 35 polyphenols in plasma samples and compared them with colon cancer risk. Only 2 chemicals showed any association. Concentrations of equol, which is metabolized from soy foods, were inversely associated with colon cancer risk. Higher levels of homovanillic acid, on the other hand, were associated with increased risk.

Published
2018
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