1. Canine mammary carcinomas: influence of histological grade, vascular invasion, proliferation, microvessel density and VEGFR2 expression on lymph node status and survival time
- Author
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Julio Roberto Idiart, Enrique Leo Portiansky, Mónica Elizabeth Diessler, María Cecilia Castellano, and Sarah Lilian Burns
- Subjects
Pathology ,medicine.medical_specialty ,PROGNOSIS ,Proliferation index ,040301 veterinary sciences ,Angiogenesis ,Mammary gland ,NEOPLASIA ,Mammary Neoplasms, Animal ,ANGIOGENESIS ,0403 veterinary science ,03 medical and health sciences ,0302 clinical medicine ,Dogs ,Mammary Glands, Animal ,Antigen ,medicine ,DOG ,Animals ,Dog Diseases ,Lymph node ,Cell Proliferation ,General Veterinary ,biology ,Neovascularization, Pathologic ,business.industry ,Ciencias Veterinarias ,MAMMARY GLAND ,Kinase insert domain receptor ,04 agricultural and veterinary sciences ,Survival Analysis ,Vascular Endothelial Growth Factor Receptor-2 ,Proliferating cell nuclear antigen ,medicine.anatomical_structure ,CIENCIAS AGRÍCOLAS ,030220 oncology & carcinogenesis ,Lymphatic Metastasis ,Microvessels ,cardiovascular system ,biology.protein ,Female ,Lymph ,Neoplasm Grading ,business - Abstract
Spontaneous invasive non-inflammatory canine mammary carcinomas (CMC) and their regional lymph nodes (LN) were analysed (n = 136). Histological grade (HG) and vascular invasion (VI) in the tumours and lymph node status were recorded. Proliferation index (PI), microvessel density (MVD) and vascular endothelial growth factor receptor 2 (VEGFR2) expression were estimated using anti-proliferating cell nuclear antigen (PCNA), anti-von Willebrand factor and anti-Flk-1, respectively. Eighteen months follow-up was performed (34 bitches). Tumours of different grades showed differences regarding PI, Flk-1/integrated optical density (Flk-1/IOD) and MVD. Every feature showed significant association with LN status through bivariate analyses. From multivariate analyses, VI and Flk-1/IOD were selected to predict LN status. Data revealed that the probability of a CMC-bearing bitch to remain alive at 1, 4, 5 and 14–18 months was 0.91, 0.87, 0.81 and 0.77, respectively. Besides LN status, VI was the only feature positively correlated with survival time, although a trend to shorter survival of animal patients bearing high expressing VEGFR2 CMC was noted. Fil: Diessler, Mónica Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas; Argentina Fil: Castellano, M.C.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina Fil: Portiansky, Enrique Leo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina Fil: Burns, Sarah. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Laboratorio de Investigación en Sistemas Ecológicos y Ambientales; Argentina Fil: Idiart, Julio Roberto. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; Argentina
- Published
- 2015