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1. Frequency of inadequate consumption of vitamin B12 and its serum levels in people with diabetes mellitus type 2 under metformin treatment in health centers of the Province of Buenos Aires

Author

Gabriela G. Márquez, María Amelia Linari, Natalia De Elia, Dayani Toledo Rosales, Alejandra E. Cáceres Insfran, and Velia A. Löbbe

Subjects
encuesta de consumo, dosaje sérico de b12, diabetes mellitus tipo 2, metformina, Nutritional diseases. Deficiency diseases, RC620-627, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction: the prolonged use of metformin and the lack of consumption of vitamin B12 can cause its deficit, in T2D. Objectives: to analyze the frequency of insufficient consumption of vitamin B12 according to: personal characteristics, anthropometric and laboratory data, and use of metformin; associate serum cobalamin levels with metformin dose and time; establish a relationship between B12 intake and serum levels. Materials and methods: cross-sectional design. Through a survey of the frequency of consumption of food sources of B12 in 200 patients treated with metformin for more than 18 months. Clinical, anthropometric, laboratory data, time and dose of metformin were analyzed in 2 health centers in the Province of Buenos Aires. Results: the percentage of de cient consumption was 29%. 47.5% of unemployment was registered, which reached an in-take deficit of 32.6%. Serum B12 was measured in 65% of the sample where 53.8% of values were abnormal (0.8% in deficient levels) and 23% at levels normal lower cut-off point, with a significant association being observed at doses of metformin ≥1,500 mg. Deficiencies in B12 intake (

Published
2022
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2. Frequency of periodontal disease in adult patients with type 2 diabetes mellitus in the Autonomous city of Buenos Aires and the province of Buenos Aires

Author

María Soledad Monod Nuñez, Lorena Verónica Aransibia, María Justina Blanco Fernández, Tomás Hernández Oropesa, and María Amelia Linari

Subjects
diabetes mellitus tipo 2, enfermedad periodontal, frecuencia, inflamación, Nutritional diseases. Deficiency diseases, RC620-627, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction: periodontal disease (PD) is a risk factor in the genesis and evolution of numerous chronic systemic diseases, such as diabetes. Both share a complex evolution constituting a bidirectional relationship. Objectives: to describe the frequency of PD in adult patients diagnosed with type 2 diabetes (T2D), as well as its severity and extension at the time of initial diagnosis, its correlation with metabolic variables and signs of complications. Materials and methods: cross-sectional study; 626 medical records of adult patients with T2D in Autonomous city of Buenos Aires and the province of Buenos Aires. Results: the frequency of PD for the sample (n=614) was 98% (gingivitis and periodontitis), the relationship between men and women was 53/47%, respectively, mean age 57.7±10.4 years. The analysis between late referral, years of diabetes and severity were not signi cant (p=0.49; p=0.7). A positive correlation was observed with poor metabolic control for both HbA1c (p=0.02) and fasting glycemia, and the microalbuminuria/creatininuria ratio (p=0.0001). A relationship was found between health coverage categories, severity, and extension of PD (p=0.0001). Patients without health coverage presented more severe conditions. Conclusions: the frequency of PD is highly signi cant in patients with T2D. A direct and signi cant correlation was found for HbA1c and microalbuminuria with respect to the severity and extension of PD, associated with microangiopathic alterations. New studies are needed on the analysis of metabolic markers of micro and macro vascular complications in association with periodontal disease.

Published
2022
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3. Prevalence of diabetes mellitus and altered fasting blood glucose at the time of pancreatic cancer diagnosis, in a group of patients assisted in a gastroenterological referral center in Argentina

Author

Ana Florencia Costa, Andrea La Cava, María Mercedes Mon Ratti, Julieta Nosetto, Marcela Carballido, María Amelia Linari, and Velia Löbbe

Subjects
diabetes mellitus, adenocarcinoma ductal de páncreas, glucemia alterada en ayunas, prevalencia., Nutritional diseases. Deficiency diseases, RC620-627, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction: diabetes mellitus (DM) is considered to be a risk factor for the development of pancreatic ductal adenocarcinoma (PDAC). Objectives: describe the prevalence of DM and of impaired fasting glucose (IFG) at the diagnosis of PDAC, among patients assisted in a gastroenterological reference center. Analyze differences in personal and nutritional characteristics in patients with both PDAC and DM; with both PDAC and IFG; and with PDAC but neither DM nor IFG. Determine the time lapse between the diagnosis of DM and the diagnosis of PDAC. Materials and methods: between October 2019 and March 2020, we analyzed 465 clinical records of PDAC-diagnosed patients over 18 years, from Oncology and Nutrition Sections. Results: 171 clinical records (36.7%) showed both PDAC and DM; 294 clinical records (63.2%) showed PDAC but not DM. In 45.1% of the former, the interval between the diagnosis of DM and that of PDAC was 10 years, respectively.

Published
2021
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4. QUALITY OF LIFE AND HEALTH BENEFITS IN PATIENTS WITH TYPE 2 DIABETES ACCORDING TO GEOGRAPHY REGION IN ARGENTINA

Author

María Amelia Linari, Claudio González, Guillermo Dieuzeide, María Florencia Badia, María Inés Argerich, Mariela Echenique, Gustavo Daniel Frechtel, Omar Álvaro, María del Carmen Babus, Leticia Barrera, Natalia Mabel Blanco Debat, Diego Botta, María Marta Curet, Raúl A. David, Alejandra Dib, Daniel Dionisi, Susana Fuentes, Sandra Geraci, Natalia Laguarde, Silvia Lapertosa, Astrid Libman, Elizabeth Méndez, Julieta Méndez, Luis Neira, María Florencia Noguero, Verónica Ojeda, Nelson Papini, Víctor Previtera, Erika Vago, Carla Wassner, and Débora Chan

Subjects
diabetes mellitus tipo 2, adulto, adherencia al tratamiento, calidad de vida, prestación de atención en salud, Nutritional diseases. Deficiency diseases, RC620-627, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction: adherence to treatment of diabetes mellitus type 2 (DT2) in the adult is a complex and multifactorial issue that combines aspects of the disease as not own, which impact on the quality of life. In Argentina there are great difficulties in paying for the entire treatment of the disease. The impact of income on health spending in DT2 is greater for lower income levels. Objectives: to analyze differences in quality of life and metabolic objectives according to geographic regions and health benefits in adults with DT2 in Argentina; know the out of pocket expenses in health and health costs linked to DT2; establish an association between out of pocket spending with socioeconomic variables and compliance with metabolic objectives.

Published
2019
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5. ADHERENCE TO TREATMENT IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN ARGENTINA DURING 2015

Author

María Amelia Linari, Claudio González, Gustavo Frechtel, Omar Álvaro, María Inés Argerich, María del Carmen Babus, María Florencia Badia, Leticia Barrera, Natalia Blanco Debat, Diego Botta, María Marta Curet, Raúl A. David, Alejandra Dib, Guillermo Dieuzeide, Daniel Dionisi, Mariela Echenique, Susana Fuentes, Sandra Geraci, Natalia Laguarde, Silvia Lapertosa, Astrid Libman, Elizabeth Méndez, Julieta Méndez, Luis Neira, María Florencia Noguero, Verónica Ojeda, Nelson Papini, Víctor Previtera, Erika Vago, Carla Wassner, and Débora Chan

Subjects
diabetes mellitus tipo 2, adultos, adherencia al tratamiento, prestación de atención en salud, Nutritional diseases. Deficiency diseases, RC620-627, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction: the interruption in the adherence to the prescribed treatments generates important obstacles which negatively impact on health indicators. Objectives: to evaluate adherence to treatment in adult patients with diabetes mellitus type 2 (DT2) in Argentina; associate with the type of health care provision and location. Materials and methods: we included 1.520 individuals belonging to eight different geographical regions of the Argentine Republic during 2015. A cross-sectional study was conducted. A self-reported validated questionnaire of multiple options with simple scoring polycotomic responses was applied. A quantitative scale and a multivariate analysis of main components were applied.

Published
2019
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6. O7 Evaluation of the Degree of Anxiety and Stress in People with Type 1 and 2 Diabetes (T1D and T2D) during quarantine due to COVID-19 pandemic in Argentina

Author

María Laura Casandra Pomares, Carolina Gómez Martín, María Carolina Muratore, Pablo Javier Ávila, Susana Beatriz Apoloni, Elizabeth Gladys Méndez, Graciela Rubin, Alejandra Carolina Maldini, María Lidia Ruiz Morosini, Silvia Gorbán de Lapertosa, Lilia Sauer, Felipe Álvarez Fernandez, Judith Bendahan, Lorena Lequi, María Amelia Linari, Viviana Sosa, María Florencia Aranguren, Joaquín González, Gabriela Macello, Milena Suppo, Javier Aníbal Vilte, María Celina Soledad Acosta, Claudio Fabián Dituro, Alejandro Daín, Claudia Karina Koleff, Carolina Figueredo, María Julia Esperanza, Jorgelina Llense, Fabian Dávila, Graciela Fuente, Silvina Soledad Gómez, Rubén Alberto Guercetti, Marisol Mantovan, Matías Ré, Rosario Puente Olivera, Sandra Noemí Salva, Noelia Burgos, Elizabeth Herrera, Sandra Aixa Kremer Sendros, Elida Romero, Oscar Gustavo Lorenzo, Silvia Rodríguez Cuimbra, Ezequiel Hernán Forte, Claudio González, Sociedad Argentina de Diabetes Graduados, Grupo de Trabajo Virtual, and Sociedad Argentina de Diabetes Capítulo Nordeste

Subjects
impacto emocional, aislamiento, covid-19., Nutritional diseases. Deficiency diseases, RC620-627, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction: The COVID-19 pandemic led to the implementation of home quarantine in many countries to prevent the spread of the virus. Since people with diabetes had to stay in their homes, mood and psychological changes related to isolation may occur. Objectives: To evaluate the psychological impact of quarantine through the determination of anxiety and stress degrees, in adults with T1D and T2D. To assess the association of the questionaries scores obtained with other independent covariates. Material and Methods: Multi-center, cross-sectional observational study. Data collection through online survey, from April 1st to May 3rd, 2020. The degree of stress was evaluated by the Perceived Stress Scale (PSS), and the degree of anxiety by the Beck Anxiety Inventory (BAI). Statistical analysis: Descriptive statistics and hypothesis confrontation tests, multiple linear regression, chi2 and Spearman's correlation coefficient. Any value of p

Published
2020
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7. P3 Influence of habits: the consumption of fiber, omega 3 and physical activity in the development of metabolic syndrome

Author

María Eugenia Leone, Lisseth Acevedo, Eleonora Marotta, Lorena Mayoraz, Elena Pastor, and María Amelia Linari

Subjects
fibra, omega 3, actividad física, síndrome metabólico, Nutritional diseases. Deficiency diseases, RC620-627, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction: Multiple factors necessary for the development of metabolic syndrome (MS) increased risk of atherothrombotic cardiovascular disease. Objectives: to study the impact and association of the consumption of fiber, omega 3 and the practice of physical activity (PA) with the prevalence of MS. Analyze the association between: fiber consumption with anthropometric values; the consumption of fiber with consumption of omega 3 and triglycerides. Method: cross-sectional study. A targeted and individualized questionnaire was conducted that included semiquantitative consumption frequency and 24-hour recall, anthropometry and convenience laboratory to 179 adults from Hospital Sirio Libanés and from a private care center in nutrition areas from September 2019 to March 2020. It was considered a diagnosis of MS according to the last IDF definition. Those with poorly absorptive intestinal pathology, psychiatric pathology, cancer treatment or without informed consent were excluded

Published
2020
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8. O3 Impact of hyperglycaemia and the therapeutic action of metformin on the length of the telomers

Author

Andrea Millán, Constanza Pautasso, Ariel López, Alejandro De Dios, Andrea Iglesias Molli, María Amelia Linari, Gustavo Frechtel, and Gloria Cerrone

Subjects
hiperglucemia, metformina, telómeros, Nutritional diseases. Deficiency diseases, RC620-627, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction: Hyperglycemia is one of the most important factors that determine the production of oxidative stress and inflammation, processes that can accelerate telomere shortening. Objectives: The objectives were to analyse the absolute telomere length (aTL) in individuals with altered fasting glucose levels (AFG) compared to individuals with normal glucose levels (NFG). To study from a prospective controlled study, the variation in aTL in patients with decompensated type 2 diabetes (T2D) before and after treatment. Materials and Methods: A population of 246 individuals of both genders was studied, which were divided into a group of individuals with blood glucose levels 50Y). A subgroup of 30 patients with newly diagnosed T2D was studied, at the beginning (T0), and at 6 months (T6) of a pharmacological treatment and hygienic-dietary measures with the objective of achieving metabolic compensation. In both studies, the biochemical-clinical variables of all individuals and the aTL were determined by quantitative real-time PCR. Statistical analyses were performed using Graph Pad Prism and SPSS software.

Published
2020
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9. MINIDEBATE 11: The paradox between technological advances and the situations of crisis and inequity during a pandemic and an epidemic context

Author

María Amelia Linari, Alejandro Daín, María Lidia Ruíz, and Gabriela Krochik

Subjects
tecnología, diabetes mellitus, Nutritional diseases. Deficiency diseases, RC620-627, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Innovative technologies bring great possibilities of increasing human well-being. However, technological progress does not guarantee equitable health outcomes. While technological advances define the way in which people, systems and information interact, communities with fewer resources tend to be left excluded, and that will subsequently have an impact on quality. Publications explain that in communities where technological solutions have been imposed, there has later been abandoned equipment, software that is incompatible and frustrated management policies. Nevertheless, there are some cases of general technological implementations that undermine equity, justice and human rights. For example, the use of high technology in medical interventions as preventive measures or diagnosis, the use of genes which prevent the reuse of crop seeds allowed for consuming, and many more. To obtain equitable results, the design and planning of the technology must respect the ethical principles, local values and their folklore, among other points. Decisions require compromise in the medium and long term and local leadership.

Published
2020
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11. Frecuencia de enfermedad periodontal en pacientes adultos con diabetes mellitus tipo 2 en la Ciudad Autónoma de Buenos Aires y la Provincia de Buenos Aires

Author

María Soledad Monod Nuñez, Lorena Verónica Aransibia, María Justina Blanco Fernández, Tomás Hernández Oropesa, and María Amelia Linari

Subjects
DIABETES MELLITUS, General Earth and Planetary Sciences, PERIODONTITIS, ARTICULO, General Environmental Science
Abstract

Introducción: la enfermedad periodontal (EP) es un factor de riesgo en la génesis y evolución de numerosas enfermedades crónicas sistémicas como la diabetes mellitus (DM). Ambas comparten una evolución compleja y constituyen una relación bidireccional.Objetivos: describir la frecuencia de EP en pacientes adultos con diagnóstico de DM2, así como su gravedad y extensión al momento del diagnóstico inicial, su correlación con variables metabólicas y signos de complicación.Materiales y métodos: estudio transversal. Se recolectaron 626 historias clínicas de pacientes adultos con DM2 en la Ciudad Autónoma de Buenos Aires (CABA) y la Provincia de Buenos Aires. Resultados: la frecuencia de EP para la muestra (n=614) fue del 98% (gingivitis y periodontitis), la relación hombres y mujeres fue de 53/47% respectivamente, y la edad media 57,7±10,4 años. El análisis entre la derivación tardía, los años de antigüedad de la DM y la gravedad no resultaron signi cativos (p=0,49; p=0,7). Se observó correlación positiva con el mal control metabólico tanto para HbA1c (p=0,02) como para las glucemias en ayunas, y la relación microalbuminuria/creatininuria (p=0,0001). Se encontró relación entre las categorías de cobertura de salud, y la gravedad y extensión de la EP (p=0,0001). Los pacientes sin cobertura de salud presentaron cuadros más severos.Conclusiones: la frecuencia de EP fue altamente signi cativa en pacientes con DM2. Se evidenció correlación directa y signi cativa para la HbA1c y la microalbuminuria con respecto a la gravedad y la extensión de la EP, asociada con alteraciones microangiopáticas. Se requieren nuevos estudios sobre el análisis de marcadores metabólicos, de complicación micro y macrovascular en asociación con la EP.

Published
2022

12. Relationship between the IL-1β serum concentration, mRNA levels and rs16944 genotype in the hyperglycemic normalization of T2D patients

Author

Mónica Paula Spalvieri, Andrea Elena Iglesias Molli, María Fernanda Bergonzi, Gustavo Daniel Frechtel, María Amelia Linari, and Gloria Edith Cerrone

Subjects
0301 basic medicine, Normalization (statistics), Adult, Blood Glucose, Male, medicine.medical_specialty, Genotype, Molecular biology, Interleukin-1beta, lcsh:Medicine, INFLAMACIÓN, Article, 03 medical and health sciences, Young Adult, 0302 clinical medicine, INTERLEUQUINA 1BETA, Medical research, purl.org/becyt/ford/3.2 [https], Genetics, Medicine, Humans, Hypoglycemic Agents, Genetic Predisposition to Disease, Prospective Studies, lcsh:Science, Alleles, Aged, Gynecology, Multidisciplinary, Molecular medicine, business.industry, lcsh:R, Serum concentration, Middle Aged, GENETICA, 030104 developmental biology, Mrna level, Diabetes Mellitus, Type 2, Hyperglycemia, DIABETES TIPO2, Leukocytes, Mononuclear, lcsh:Q, purl.org/becyt/ford/3 [https], Female, business, 030217 neurology & neurosurgery
Abstract

To evaluate Interleukin 1-beta (IL-1β) serum and mononuclear leucocyte mRNA levels, also rs16944 (−511C/T) genotype, in relation to hyperglycemic normalization in Type 2 diabetes (T2D) patients, we recruited 30 individuals recently T2D diagnosed with hyperglycemia studied at basal time and after 6 and 12 months of the normalization treatment. At basal time, the T polymorphic allele of the rs16944 was associated with lower IL-1β mRNA expression (p = 0.006); and higher glucose level was positive correlated to IL-1β protein levels (p = 0.015). After treatment, the individuals showed a significant decrease in glucose level (p = 0.003), but they did not express significant changes in the IL-1β serum levels. Surprisingly, we observed that the greater decreases in glucose level were associated to increased IL-1β serum levels (p = 0.040). This is the first follow-up study evaluating IL-1β mRNA expression and serum levels in hyperglycemic T2D individuals and after glycemic normalization treatment. The current results contribute to the knowledge of the relationship between inflammation and glucose metabolism in T2D. Fil: Iglesias Molli, Andrea Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Bergonzi, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Spalvieri, Mónica Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Linari, María Amelia. Union Obrera Metalurgica.; Argentina Fil: Frechtel, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina Fil: Cerrone, Gloria Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina

Published
2020

13. Cumplimiento, control de objetivos metabólicos, motivos de incumplimiento al tratamiento y a las recomendaciones prescriptas en adultos con diabetes tipo 2 en Argentina en 2015

Author

Gustavo Daniel Frechtel, Silvia Gorbán de Lapertosa, Guillermo Dieuzeide, Carla Wassner, Claudio González, Omar Álvaro, Diego Botta, Astrid Libman, Mariela Echenique, Verónica Ojeda, Erika Vago, María Amelia Linari, Nelson Papini, María Florencia-Badias, Elizabeth Méndez, Sandra Geraci, María Inés Argerich, María Marta Curet, Susana Fuentes, Julieta Méndez, Víctor Previtera, María del Carmen Babus, María Florencia-Noguerol, and Débora Chan

Subjects
General Earth and Planetary Sciences, General Environmental Science
Published
2019
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14. P10 Prevalencia de diabetes mellitus y glucemia en ayuno alterada al momento del diagnóstico de cáncer de páncreas en un grupo de pacientes asistidos en un centro de referencia gastroenterológico en Argentina

Author

Andrea La Cava, Julieta Nosetto, María Amelia Linari, Ana Florencia Costa, María Mercedes Mon Ratti, Velia Lobbe, and Marcela Carballido

Subjects
Gynecology, medicine.medical_specialty, Pancreatic ductal adenocarcinoma, endocrine system diseases, business.industry, Impaired fasting glucose, medicine.disease, digestive system diseases, Pancreatic cancer, Diabetes mellitus, medicine, General Earth and Planetary Sciences, In patient, Risk factor, business, Clinical record, General Environmental Science
Abstract

Introduction : diabetes mellitus (DM) is considered to be a risk factor for the development of pancreatic ductal adenocarcinoma (PDAC). Objectives : describe the prevalence of DM and of impaired fasting glucose (IFG) at the diagnosis of PDAC, among patients assisted in a gastroenterological reference center. Analyze differences in personal and nutritional characteristics in patients with both PDAC and DM; with both PDAC and IFG; and with PDAC but neither DM nor IFG. Determine the time lapse between the diagnosis of DM and the diagnosis of PDAC. Materials and methods : between October 2019 and March 2020, we analyzed 465 clinical records of PDAC-diagnosed patients over 18 years, from Oncology and Nutrition Sections. Results : 171 clinical records (36.7%) showed both PDAC and DM; 294 clinical records (63.2%) showed PDAC but not DM. In 45.1% of the former, the interval between the diagnosis of DM and that of PDAC was 10 years, respectively.

Published
2020
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15. P3 Influencia de hábitos: el consumo de fibra, el omega 3 y la actividad física en el desarrollo de síndrome metabólico

Author

Lisseth Acevedo, Eleonora Marotta, Elena Pastor, María Eugenia Leone, María Amelia Linari, and Lorena Mayoraz

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Physical activity, Care center, Anthropometry, medicine.disease, Cancer treatment, Increased risk, Multiple factors, medicine, General Earth and Planetary Sciences, Metabolic syndrome, business, General Environmental Science
Abstract

Introducción: múltiples factores contribuyen al desarrollo de síndrome metabólico (SM) aumentando el riesgo de enfermedad cardiovascular aterotrombótica.Objetivos: estudiar el impacto y la asociación del consumo de fibra, omega 3 y la práctica de actividad física (AF) con la prevalencia de SM. Analizar la asociación entre: el consumo de fibra con valores antropométricos, el consumo de fibra con consumo de omega 3 y triglicéridos.Materiales y métodos: estudio transversal. Se realizó cuestionario dirigido e individualizado que incluyó frecuencia de consumo semicuantitativo y recordatorio de 24 horas, antropometría y laboratorio por conveniencia a 179 adultos del Hospital Sirio Libanés y de un centro de asistencia privada en áreas de nutrición de septiembre de 2019 a marzo 2020. Se consideró diagnóstico de SM según ultima definición de IDF. Se excluyeron aquellos con patología intestinal malabsortiva, patología psiquiátrica, tratamiento oncológico o sin consentimiento informado.

Published
2020
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16. O3 Impacto de la hiperglucemia y de la relación de la acción terapéutica de la metformina en la longitud de los telómeros

Author

Ariel Pablo Lopez, Andrea Elena Iglesias Molli, Gustavo Daniel Frechtel, María Amelia Linari, Alejandro de Dios, Gloria Edith Cerrone, Andrea Millán, and Constanza Pautasso

Subjects
Gynecology, education.field_of_study, medicine.medical_specialty, business.industry, Population, Newly diagnosed, Type 2 diabetes, medicine.disease, Metformin, Pharmacological treatment, Fasting glucose, medicine, General Earth and Planetary Sciences, In patient, business, education, After treatment, General Environmental Science, medicine.drug
Abstract

Introducción: la hiperglucemia es uno de los más importantes factores que determinan la producción de estrés oxidativo e inflamación, procesos que pueden acelerar el acortamiento de los telómeros.Objetivos: analizar la longitud telomérica absoluta (LTa) en individuos con niveles de glucosa en ayunas alterada (GAA) en comparación con individuos que presentan niveles normales de glucosa (GAN). Estudiar a partir de un estudio prospectivo controlado, la variación en la LTa en pacientes con DM2 descompensada antes y después del tratamiento.Materiales y métodos: se estudió una población de 246 individuos de ambos sexos, conformada por individuos con obesidad, individuos con DM2 o MODY e individuos controles sanos. Se dividieron en individuos con niveles de glucemia =110 mg/dl y 50Y). Se estudió un subgrupo de 30 pacientes con DM2 de reciente diagnóstico, al inicio (T0) y a los 6 meses (T6) de un tratamiento farmacológico y medidas higiénico-dietéticas, con el objetivo de lograr la compensación metabólica. En ambos estudios se determinaron las variables bioquímico-clínicas de todos los individuos y la LTa por PCR cuantitativa en tiempo real. Los análisis estadísticos se realizaron utilizando el software GraphPad Prism y SPSS.

Published
2020
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17. MINI DEBATE 11: Paradoja entre los adelantos tecnológicos y las situaciones de crisis e inequidad en el contexto de epidemias y pandemias

Author

Gabriela Krochik, María Amelia Linari, Alejandro Daín, and María Lidia Ruiz

Subjects
Equity (economics), Folklore, Human rights, Technological change, Welfare economics, media_common.quotation_subject, Compromise, Psychological intervention, Reuse, Political science, General Earth and Planetary Sciences, Implementation, General Environmental Science, media_common
Abstract

Las tecnologías innovadoras tienen grandes posibilidades de aumentar el bienestar humano. Sin embargo, el progreso tecnológico no garantiza resultados sanitarios equitativos. Mientras los adelantos de la tecnología definen la forma en que las personas, los sistemas y la información interactúan, las comunidades de menores recursos suelen quedar excluidas y eso impacta luego en calidad. Las publicaciones refieren que en comunidades donde se han impuesto soluciones tecnológicas, luego hubo equipos abandonados, programas informáticos incompatibles y políticas con gestiones frustradas. No obstante se encuentran casos de aplicaciones tecnológicas en general que socavan la equidad, la justicia y los derechos humanos: por ejemplo, el uso de intervenciones médicas de alta tecnología para medidas preventivas o de diagnóstico, el empleo de genes que impiden la reutilización de semillas de cultivos alimentarios, etc. Para obtener resultados equitativos, el diseño y la planificación de la tecnología deben respetar los principios éticos, los valores locales y su folklore, entre otros puntos. Las decisiones requieren compromiso a mediano y largo plazo, además de protagonismo local.

Published
2020
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18. NETosis before and after Hyperglycemic Control in Type 2 Diabetes Mellitus Patients

Author

Claudio Gonzalez, Agostina Carestia, María Amelia Linari, Mirta Schattner, Patricia Casais, Gloria Edith Cerrone, and Gustavo Daniel Frechtel

Subjects
Male, 0301 basic medicine, Neutrophils, Physiology, Gene Expression, lcsh:Medicine, Type 2 diabetes, Extracellular Traps, White Blood Cells, Endocrinology, Animal Cells, Immune Physiology, Medicine and Health Sciences, Platelet, Endothelial dysfunction, lcsh:Science, Innate Immune System, Multidisciplinary, biology, Chromosome Biology, Hematology, Middle Aged, Chromatin, Nucleosomes, Body Fluids, Type 2 Diabetes, Blood, Cytokines, Epigenetics, Female, Cellular Types, Anatomy, Research Article, Platelets, Blood Platelets, medicine.medical_specialty, Endocrine Disorders, Immune Cells, Immunology, Blood Plasma, 03 medical and health sciences, Von Willebrand factor, Internal medicine, Diabetes mellitus, Diabetes Mellitus, Genetics, medicine, Humans, Hypoglycemic Agents, Platelet activation, Blood Coagulation, Inflammation, Blood Cells, business.industry, lcsh:R, Biology and Life Sciences, Type 2 Diabetes Mellitus, Cell Biology, Neutrophil extracellular traps, Molecular Development, Platelet Activation, medicine.disease, Glucose, 030104 developmental biology, Diabetes Mellitus, Type 2, Metabolic Disorders, Immune System, Case-Control Studies, Hyperglycemia, biology.protein, lcsh:Q, business, Developmental Biology
Abstract

Introduction and Objective Diabetes is characterized by chronic inflammation, endothelial dysfunction, increased risk of infections and early cardiovascular disease. By releasing neutrophil extracellular traps (NETs), neutrophils kill bacteria and exert pro-inflammatory and pro-thrombotic activities. Increased NETosis has been found in cross-sectional studies including treated type 2 diabetes mellitus (T2DM) patients. In this study, we determined whether the ability of neutrophils to form NETs differs in diabetic patients pre- and post-hyperglycemic control versus healthy donors (HD), and the relationship between NETosis with pro-thrombotic, pro-inflammatory biomarkers and thrombotic clinical events. Methods Diabetic patients recently diagnosed and after 6 and 12 months of treatment (N = 25) and HD (N = 25) were included. NET formation was studied by microscopy and fluorometry. Nucleosomes, HNE-DNA complexes, von Willebrand factor (vWF), IL6 and TNFα plasma levels were measured by ELISA and P-selectin on the platelet surface was assessed by cytometry. Results Basal levels of NETs in recently diagnosed T2DM patients were higher compared to HD. While TNFα stimulation of control neutrophils resulted in DNA release, patient neutrophils were not responsive. Although glycemia decreased after 6 months of metformin treatment, basal and TNFα and PMA-stimulated NETs reached normal values after 12 months. Compared to controls, nucleosomes, HNE-DNA complexes, IL-6 and TNFα levels were increased in recently diagnosed patients and decreased after 12 months of treatment. P-selectin and vWF levels were similar in both populations. Conclusion Our data suggest that NETs could represent a biomarker for T2DM. Increased NETosis in T2DM patients does not appear to be the consequence of impaired glycemic control but rather due to pro-inflammatory cytokines and is not related to thrombotic events.

Published
2016

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