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We study the magnetic activity in the ultrafast rotator dMe HK Aqr using tomography techniques with high-resolution spectroscopy. We aim to characterize how this magnetic activity appears in a regime of very fast rotation without external forces, given that HK Aqr is, very likely, a single star. We find dark spots located at low latitudes. We also detect prominences below the co-rotation radius and at low latitudes, coinciding with the spot latitudes. This apparent low-latitude activity contrasts with what is typically observed in fast rotators, which tend to form large polar spots. Moreover, we detect a stellar flare that produces an enhancement of the continuum and additional emission in the core of most photospheric and chromospheric lines. We find evidence that the flare is ignited above an active region, as seen in solar flares. This means that, with high probability, the flare is initiated by magnetic reconnection in complex active regions. We also present evidence of bulk redshifted velocities of about 15 km s−1 during the rise of the flare, and velocities of 5–10 km s−1 during the decay phase. An estimation of the heating during the flare results in about 200 kK close to the peak and in 100 kK at the end of the observations.

The importance of the quiet-Sun magnetism is that it is always there to a greater or lesser extent, being a constant provider of energy, independently of the solar cycle phase. The open questions about the quiet-Sun magnetism include those related to its origin. Most people claim that the local dynamo action is the mechanism that causes it. This fact would imply that the quiet-Sun magnetism is nearly the same at any location over the solar surface and at any time. Many works claim that the quiet Sun does not have any variation at all, although a few of them raise doubt on this claim and find mild evidence of a cyclic variation in the the quiet-Sun magnetism. In this work, we detect clear variations in the internetwork magnetism both with latitude and solar cycle. In terms of latitude, we find an increase in the averaged magnetic fields toward the solar poles. We also find long-term variations in the averaged magnetic field at the disk center and solar poles, and both variations are almost anticorrelated. These findings do not support the idea that the local dynamo action is the unique factory of the quiet-Sun magnetism., Comment: 8 pages, 4 figures, 1 table

Antecedentes El conducto arterioso permeable (CAP) es un defecto cardiaco congenito y se considera un problema de salud publica. Se presenta en un alto porcentaje de recien nacidos y en algunos mayores de 1 mes. El cierre farmacologico es el tratamiento inicial preferido, ya que ha tenido excelentes resultados; sin embargo, en aquellos casos en los que no es posible, esta indicado el cierre quirurgico. Objetivo Evaluar la eficacia y la seguridad del cierre quirurgico del CAP por cirujanos pediatras sin especialidad en cirugia cardiovascular. Metodo Ensayo clinico realizado en pacientes del Hospital General de Occidente, centro hospitalario publico de segundo nivel, con diagnostico de CAP, que requirieron correccion quirurgica. Se revisaron en forma retrospectiva los expedientes de enero de 2001 a diciembre de 2018. Resultados Se incluyeron 224 pacientes divididos en dos grupos: grupo I, con 184 (82%) recien nacidos, y grupo II, con 40 (18%) ninos grandes de 2 meses a 8 anos de edad. A todos se les realizo cierre quirurgico: 3 por toracoscopia y 221 por toracotomia posterolateral izquierda. Presentaron complicaciones 36 pacientes, lo que representa el 16% del total; solo el 5.3% fueron complicaciones mayores. Fallecieron 24 pacientes en el posoperatorio, lo que representa una mortalidad del 10.7%; ninguno fallecio por complicaciones transquirurgicas. El CAP es un defecto cardiaco congenito que se presenta en alto porcentaje en pacientes prematuros. El cierre farmacologico es el principal tratamiento por tener excelentes resultados en recien nacidos; sin embargo, en aquellos casos en los que no sea posible esta indicado el cierre quirurgico. Todos los pacientes fueron operados por cirujanos pediatras generales, con una sobrevida global del 92%. Conclusiones En los hospitales donde no hay cirujano cardiovascular pediatrico ni cardiologo intervencionista, la correccion quirurgica del CAP puede ser llevada a cabo por un cirujano pediatra. La tecnica es reproducible, facil de realizar y con minimas complicaciones. Background The Patent Ductus Arteriosus (PDA) is congenital heart defect and is considered a public health problem. It occurs in a high percentage of newborns and in some older than 1 month. Pharmacological closure is the preferred initial treatment, as it has had excellent results; however, in those cases where it is not possible, surgical closure is indicated. Objective The objective is to evaluate the efficacy and safety of the surgical closure of the patent PDA when it is carried out by pediatric surgeons without specialization in cardiovascular surgery. Methods This study was conducted at the West General Hospital, a 2nd level public hospital, with the diagnosis of patent ductus arteriosus that required surgical correction. For the collection of the information, the files from January 2001 to December 2018 were retrospectively reviewed. Results 224 patients were included; divided into two groups: Group I: 184 (82%) “newborns” and Group II: 40 (18%) “big children” with ages from 2 months to 8 years. All had a surgical closure; 3 by thoracoscopy and 221 by left posterolateral thoracotomy. 36 patients presented complications representing 16% of the total of patients, only 5.3% were major complications. 24 patients died in the postoperative period, representing a mortality of 10.7%, none died due to trans-surgical complications. PDA is a congenital heart defect that occurs in a high percentage of premature patients. The pharmacological closure is the principal treatment because it has had excellent results in newborns; however, in those cases where it is not possible, surgical closure it´s indicated. All patients were operated by general pediatric surgeons, with a global survival of 92%. Conclusions We conclude that in hospitals where there is no pediatric cardiovascular surgeon or interventional cardiologist, the surgical correction of the PDA can be carried out by a general pediatric surgeon. The technique is reproducible, easy to perform and with minimal complications.

Resumen Antecedentes y objetivo Previamente se habia iniciado el proceso metodologico para la validacion transcultural al idioma espanol de la escala Hair Specific Skindex-29 (HSS-29), que mide el impacto de la alopecia androgenica femenina sobre la calidad de vida relacionada con la salud (CVRS). Para finalizar el proceso, el objetivo del estudio fue completar la validacion a traves de la determinacion de su sensibilidad al cambio y su correlacion con una escala generalista de CVRS (SF-12). Material y metodo Se establecieron dos visitas, una basal y otra tras 6 meses de tratamiento con suplemento alimenticio con actividad inhibidora de la enzima 5-alfa reductasa. En cada visita, investigadores y pacientes valoraron la gravedad de la alopecia mediante la escala Sinclair, el estado de la apariencia del cabello, y se administraron las escalas HSS-29 y SF-12. Resultados Participaron 983 mujeres con alopecia androgenica. La media de puntuacion en la escala HSS-29 cambio de 27,5 ± 18,7 en la visita basal a 19,3 ± 15,7 en la de seguimiento, y sus dimensiones funcional, emocional y sintomatica tambien cambiaron significativamente. Tanto las diferencias entre basal y seguimiento en el indice HSS-29 global como en cada una de sus dimensiones se correlacionaron significativamente con las diferencias encontradas en las dimensiones de SF-12. Los coeficientes de correlacion de Pearson oscilaron entre −0,1 y −0,4, y en todos los casos el grado de significacion fue p Conclusiones La version en espanol de la escala HSS-29 posee sensibilidad, es decir, detecta cambios relacionados con la calidad de vida cuando las condiciones objetivas varian. Igualmente, se observo una correlacion entre las escalas HSS-29 y SF-12.

La cardiologia pediatrica y la cirugia cardiovascular han tenido avances importantes en los ultimos anos; las cardiopatias congenitas (CC) son una de las principales causas de mortalidad en ninos. Muchos de los factores que determinan la evolucion final de estos pacientes incluyen el tipo de cardiopatia y el tiempo del diagnostico y tratamiento; infortunadamente, dos de los que presentan mayores efectos son el estado socioeconomico y el area geografica de atencion en Mexico. El objetivo de este estudio es conocer el tipo de atencion para los pacientes con CC en hospitales publicos del pais. Pediatric cardiology and cardiovascular surgery have made significant advances in recent years, congenital heart diseases (CHD) are one of the leading causes of mortality in children. Many of the factors that determine the final evolution of these patients include the type of heart disease, the time of diagnosis and treatment; unfortunately, in our country, two of those greatest impact area the socioeconomic status and the geographic area of attention. The objective of this study is to know the type of care for patients with CHD in public hospitals in the country.

The EARS2 nuclear gene encodes mitochondrial glutamyl-tRNA synthetase, a member of the class I family of aminoacyl-tRNA synthetases (aaRSs) that plays a crucial role in mitochondrial protein biosynthesis by catalyzing the charging of glutamate to mitochondrial tRNA(Glu). Pathogenic EARS2 variants have been associated with a rare mitochondrial disorder known as leukoencephalopathy with thalamus and brainstem involvement and high lactate (LTBL). The targeted sequencing of 150 nuclear genes encoding respiratory chain complex subunits and proteins implicated in the oxidative phosphorylation (OXPHOS) function was performed. The oxygen consumption rate (OCR), and the extracellular acidification rate (ECAR), were measured. The enzymatic activities of Complexes I-V were analyzed spectrophotometrically. We describe a patient carrying two heterozygous EARS2 variants, c.376C>T (p.Gln126*) and c.670G>A (p.Gly224Ser), with infantile-onset disease and a severe clinical presentation. We demonstrate a clear defect in mitochondrial function in the patient’s fibroblasts, suggesting the molecular mechanism underlying the pathogenicity of these EARS2 variants. Experimental validation using patient-derived fibroblasts allowed an accurate characterization of the disease-causing variants, and by comparing our patient’s clinical presentation with that of previously reported cases, new clinical and radiological features of LTBL were identified, expanding the clinical spectrum of this disease.

The EARS2 nuclear gene encodes mitochondrial glutamyl-tRNA synthetase, a member of the class I family of aminoacyl-tRNA synthetases (aaRSs) that plays a crucial role in mitochondrial protein biosynthesis by catalyzing the charging of glutamate to mitochondrial tRNA(Glu). Pathogenic EARS2 variants have been associated with a rare mitochondrial disorder known as leukoencephalopathy with thalamus and brainstem involvement and high lactate (LTBL). The targeted sequencing of 150 nuclear genes encoding respiratory chain complex subunits and proteins implicated in the oxidative phosphorylation (OXPHOS) function was performed. The oxygen consumption rate (OCR), and the extracellular acidification rate (ECAR), were measured. The enzymatic activities of Complexes I-V were analyzed spectrophotometrically. We describe a patient carrying two heterozygous EARS2 variants, c.376C&gt, T (p.Gln126*) and c.670G&gt, A (p.Gly224Ser), with infantile-onset disease and a severe clinical presentation. We demonstrate a clear defect in mitochondrial function in the patient&rsquo, s fibroblasts, suggesting the molecular mechanism underlying the pathogenicity of these EARS2 variants. Experimental validation using patient-derived fibroblasts allowed an accurate characterization of the disease-causing variants, and by comparing our patient&rsquo, s clinical presentation with that of previously reported cases, new clinical and radiological features of LTBL were identified, expanding the clinical spectrum of this disease.

Resumen La alimemazina (Variargil®) es un antihistaminico anti-H1 reversible inespecifico que atraviesa la barrera hematoencefalica. Actua como anticolinergico. Su forma de presentacion es en gotas en suspension oral. Su uso clinico esta extendido a rinitis alergica estacional, angioedema y urticaria leve a partir de los 2 anos de edad, conjuntivitis alergica e insomnio de conciliacion en la infancia. Presenta una farmacocinetica muy variable, somnolencia excesiva conocida como «heavy hangover» y efecto de rebote tras su retirada. No esta autorizado su uso en menores de 2 anos. Presentamos el caso de un paciente de 19 meses que acude a Urgencias por referir somnolencia y falta de respuesta a estimulos tras la administracion de alimemazina por dificultad para conciliar el sueno.

In some centers, the pulse oximetry is not performed with the justification of lack of the adequate oximeter. We compared the effectiveness of two brands of oximeters to perform it.In neonates, a term of the joint housing service of the Hospital General de Occidente in Zapopan, Jalisco, Mexico, from May to November 2018, an examination of the characteristics of the American Academy of Pediatrics with both oximeters (ChoiceMMed® and Masimo SET®) was carried out, comparing the detection of critical congenital heart disease, time of intake, and false positives.In each group, 1022 patients were analyzed; with the Masimo SET® oximeter, 83 positive tests were obtained (8.12%), of which 22 cases had some heart disease (26.5%), which represents a sensitivity of 100%, specificity of 93.9%, positive predictive value of 26.5%, and negative predictive value of 100% (odds ratio [OR]: 0.73; 95% confidence interval [CI] 0.6-0.8). With the ChoiceMMed® oximeter, 168 positive tests were obtained (16.4%), of which 22 cases had some heart disease (13.09%), with a sensitivity of 100%, specificity of 85.4%, positive predictive value of 13.09%, and negative predictive value 100% (OR: 0.86; 95%CI: 0.8-0.92). Regarding the time to perform the cardiac sieve, the mean in minutes of the Masimo SET® oximeter was 5.38 and the ChoiceMMed® oximeter was 9.7 min.The ChoiceMMed® oximeter contains a large number of false positives and a greater number of echocardiograms and comparatively longer cardiac screen printing with Masimo SET®, however, both with a negative predictive value of 100% eliminating such excuses.En algunos centros el tamiz cardíaco no se realiza con la justificación de no tener el oxímetro adecuado. Comparamos la efectividad de dos marcas de oxímetros para realizarlo.En los neonatos a término del Servicio de alojamiento conjunto del Hospital General de Occidente en Zapopan Jalisco México de mayo a noviembre del 2018 se realizó tamiz cardíaco según las guías de la Academia Americana de Pediatría con dos oxímetros, el Masimo SET® (aprobado por la FDA) y el ChoiceMMed®, comparando su efectividad para la detección de cardiopatías congénitas críticas, el tiempo de toma y los falsos positivos.En cada grupo se analizaron 1,022 pacientes; con el oxímetro Massimo SET® se obtuvieron 83 pruebas positivas (8.12%) de las cuales 22 casos presentaron alguna cardiopatía (26.5%), lo que representa una sensibilidad del 100%, una especificidad del 93.9%, un valor predictivo positivo del 26.5% y un valor predictivo negativo del 100% (Odd Ratio [OR]: 0.73; IC 95%: 0.6-0.8). Con el oxímetro ChoiceMMed® se obtuvieron 168 pruebas positivas (16.4%), de las cuales 22 casos presentaron alguna cardiopatía (13.09%), con una sensibilidad del 100%, una especificidad del 85.4%, un valor predictivo positivo del 13.09% y un valor predictivo negativo del 100% (OR: 0.86; IC 95%: 0.8-0.92). En cuanto al tiempo para realizar el tamiz cardíaco, la media en minutos del oxímetro Masimo SET® fue 5.38 y del oxímetro ChoiceMMed® fue 9.7 minutos.El oxímetro ChoiceMMed® presentó mayor cantidad de falsos positivos y mayor tiempo de realización del tamiz cardíaco en comparación al Masimo SET®, sin embargo, ambos presentan un valor predictivo negativo del 100%, siendo igualmente útiles como método de detección de cardiopatías críticas.

In some centers the pulse oximetry is not performed with the justification of lack of the adequate oximeter. We compared the effectiveness of two brands of oximeters to perform it.In neonates a term of the joint housing service of a Hospital General de Occidente in Zapopan Jalisco Mexico from May-November 2018, an examination of the characteristics of the American Academy of Pediatrics with both oximeters (ChoiceMMed® and Masimo SET®) was carried out, comparing the detection of critical congenital heart disease (CCC), time of intake and false positives.In each group 1,022 patients were analyzed; with the Masimo SET® oximeter 83 positive tests were obtained (8.12%), of which 22 cases had some heart disease (26.5%), which represents a sensitivity of 100%, specificity of 93.9%, positive predictive value of 26.5% and negative predictive value of 100% (OR: 0.73; 95% CI: 0.6-0.8). With the ChoiceMMed® oximeter, 168 positive tests were obtained (16.4%), of which 22 cases had some heart disease (13.09%), with a sensitivity of 100%, specificity of 85.4%, positive predictive value of 13.09% and negative predictive value 100% (OR: 0.86; 95% CI: 0.8-0.92). Regarding the time to perform the cardiac sieve, the mean in minutes of the Masimo SET® oximeter was 5.38 and the ChoiceMMed® oximeter was 9.7 minutes.The ChoiceMMed® oximeter contains a large number of false positives and a greater number of echocardiograms and comparatively longer cardiac screen printing with Masimo SET®, however, both with a negative predictive value of 100% eliminating such excuses.En algunos centros el tamiz cardíaco no se realiza con la justificación de no tener el oxímetro adecuado. Comparamos la efectividad de dos marcas de oxímetros para realizarlo.En los neonatos a término del Servicio de alojamiento conjunto del Hospital General de Occidente en Zapopan Jalisco México de mayo a noviembre del 2018 se realizó tamiz cardíaco según las guías de la Academia Americana de Pediatría con dos oxímetros, el Masimo SET® (aprobado por la FDA) y el ChoiceMMed®, comparando su efectividad para la detección de cardiopatías congénitas críticas, el tiempo de toma y los falsos positivos.En cada grupo se analizaron 1,022 pacientes; con el oxímetro Massimo SET® se obtuvieron 83 pruebas positivas (8.12%) de las cuales 22 casos presentaron alguna cardiopatía (26.5%), lo que representa una sensibilidad del 100%, una especificidad del 93.9%, un valor predictivo positivo del 26.5% y un valor predictivo negativo del 100% (Odd Ratio [OR]: 0.73; IC 95%: 0.6-0.8). Con el oxímetro ChoiceMMed® se obtuvieron 168 pruebas positivas (16.4%), de las cuales 22 casos presentaron alguna cardiopatía (13.09%), con una sensibilidad del 100%, una especificidad del 85.4%, un valor predictivo positivo del 13.09% y un valor predictivo negativo del 100% (OR: 0.86; IC 95%: 0.8-0.92). En cuanto al tiempo para realizar el tamiz cardíaco, la media en minutos del oxímetro Masimo SET® fue 5.38 y del oxímetro ChoiceMMed® fue 9.7 minutos.El oxímetro ChoiceMMed® presentó mayor cantidad de falsos positivos y mayor tiempo de realización del tamiz cardíaco en comparación al Masimo SET®, sin embargo, ambos presentan un valor predictivo negativo del 100%, siendo igualmente útiles como método de detección de cardiopatías críticas.

With the Semantic Web, thesauri regain a relevant role supporting semantic searches and other added-value services. Thesaurus standards define the constructs a thesaurus can have and the integrity rules it must comply with. Thesaurus editors can be helped in their work if thesaurus tools offer them support for integrity, warning when integrity rules are violated and/or helping them to correct these mistakes. The most recent thesaurus standard is ISO 25964, which supersedes ISO 2788, evolving towards concept-based thesauri and better aligned with the Semantic Web approach than the term-based thesauri of ISO 2788. However, the W3C recommendation for Knowledge Organisation System (KOS) representation in the semantic web context is Simple Knowledge Organisation Systems (SKOS), which is in fact prior to ISO 25964. This article focuses on thesaurus integrity and the evolution from ISO 2788 to ISO 25964. Its effect on integrity issues is analysed. A methodological proposal for evaluating integrity support in thesaurus tools, arising from the results of this work, is presented. Its target audience is professionals in charge of thesaurus editing. Besides being adapted to the most recent thesaurus standard, ISO 25964, it also includes the comparison of ISO standards with SKOS. The article concludes with the presentation of the results obtained by applying the framework to three thesaurus tools.

La paz debe lograrse entre todos; desde dentro de las familias en cada hogar y en los entornos escolares, por medio de maestros y alumnos. Es relevante la funcion que le corresponde al docente en ese trabajo diario que lucha por la paz. Para llegar a ella, es necesario antes entender algunos origenes de la violencia desde las edades tempranas de la educacion basica. Principalmente, con los adolescentes, quienes pasan por una etapa de su vida en la que pueden tocar los linderos de la violencia y perderse en ella. Para evitarlo, padres y maestros deberan marcarles limites. Disciplina, comunicacion y programas preventivos son algunas de las acciones que se habran de tomar para lograrlo. En las escuelas, los retos de los maestros son enormes. Para consolidar una cultura de paz hay que vivir valores como tolerancia, libertad, responsabilidad, justicia, cooperacion y respeto. Y asi, lograr la paz por la distribucion equitativa del poder.

BACKGROUND: Herpes simplex encephalitis can trigger autoimmune encephalitis that leads to neurological worsening. We aimed to assess the frequency, symptoms, risk factors, and outcomes of this complication. METHODS: We did a prospective observational study and retrospective analysis. In the prospective observational part of this study, we included patients with herpes simplex encephalitis diagnosed by neurologists, paediatricians, or infectious disease specialists in 19 secondary and tertiary Spanish centres (Cohort A). Outpatient follow-up was at 2, 6, and 12 months from onset of herpes simplex encephalitis. We studied another group of patients retrospectively, when they developed autoimmune encephalitis after herpes simplex encephalitis (Cohort B). We compared demographics and clinical features of patients who developed autoimmune encephalitis with those who did not, and in patients who developed autoimmune encephalitis we compared these features by age group (patients =4 years compared with patients >4 years). We also used multivariable binary logistic regression models to assess risk factors for autoimmune encephalitis after herpes simplex encephalitis. FINDINGS: Between Jan 1, 2014, and Oct 31, 2017, 54 patients with herpes simplex encephalitis were recruited to Cohort A, and 51 were included in the analysis (median age 50 years [IQR 5-68]). At onset of herpes simplex encephalitis, none of the 51 patients had antibodies to neuronal antigens; during follow-up, 14 (27%) patients developed autoimmune encephalitis and all 14 (100%) had neuronal antibodies (nine [64%] had NMDA receptor [NMDAR] antibodies and five [36%] had other antibodies) at or before onset of symptoms. The other 37 patients did not develop autoimmune encephalitis, although 11 (30%) developed antibodies (n=3 to NMDAR, n=8 to unknown antigens; p

Introduction Mutations in the titin gene (TTN) are related to a wide spectrum of disease. In recent years, congenital titinopathy has emerged as a cause of severe early onset myopathy. Case report A case of two female sisters born at 32 weeks of gestation by cesarean section, from a non-consanguineous, healthy couple. They had normal prenatal ultrasounds except from equinovarus foot in one twin. Apgar score was low at birth (6–10 at 1 and 5 min in both). Both girls needed ventilator support because of respiratory insufficiency, severe axial hypotonia, multiple joint contractures distal and proximal and multiple long bone fractures. Chromosomopathy and osteogenesis imperfect were ruled out in the Genetic unit of our institution. Cardiological studies were normal. The neurographic study performed at two months of life showed extremely low amplitudes of the CMAPs with normal conduction velocities and relative preservation of the SNAPs, without clear myopathic features or spontaneous activity in the needle EMG. The whole exome sequencing (GenExComplete) revealed two extremely rare mutations in the titin gene, only expressed in the fetal skeletal transcript of TTN. One of the twins died at 8 months of age from pneumonia and the other baby needs mechanical ventilation for life support to date. Conclusions In a case of severe congenital myopathy without cardiac involvement, it is essential to consider the global clinical context. Although very rare, mutations in the fetal skeletal transcript of TTN should be excluded.

To date, few cases of 3p proximal interstitial deletions have been reported and the phenotype and genotype correlation is not well understood. Here, we report a new case of a 3p proximal interstitial deletion. The patient is an 11-year-old female with speech and social interaction difficulties, learning disability, and slight facial dysmorphism, but no other major malformations. An 8 Mb de novo interstitial deletion at 3p14.2-p14.1, from position 60.461.316 to 68.515.453, was revealed by means of array comparative genomic hybridization and confirmed using quantitative reverse-transcription polymerase chain reaction assays. This region includes six genes:FEZF2, CADPS, SYNPR, ATXN7, PRICKLE, andMAGI1, that are known to have a role in neurodevelopment. These genes are located on the proximal side of the deletion. We compare our case with previously well-defined patients reported in the literature and databases.

La toxicologia forense requiere resultados analiticos cientificamente indiscutibles y legalmente defendibles. Disponer de datos analiticos fiables es indispensable para interpretar correctamente los resultados toxicologicos. Los criterios analiticos en toxicologia forense, basados en las normativas y recomendaciones vigentes son proporcionados por prestigiosos organismos de ambito internacional y local, y su cumplimiento es fundamental para obtener resultados toxicologicos cientificamente solidos. Este trabajo supone una continuacion en la revision y evaluacion de los criterios analiticos en toxicologia forense, iniciada con el anterior trabajo recientemente publicado en esta revista «Criterios cualitativos en toxicologia forense». Su objetivo es contribuir a la calidad de la pericia y al avance en la unidad de criterio cientifico, aspectos cruciales en toxicologia forense. Este trabajo revisa, evalua y recopila los criterios para una correcta cuantificacion detallandose los requisitos para validar las metodologias. Ademas, pretende servir a aquellos profesionales que deban evaluar resultados toxicologicos emitidos por laboratorios forenses.

Exposure to ultraviolet-A (UVA) light can accidentally cause adverse effects in the skin and eyes. UVA induces DNA damage directly by creating pyrimidine dimers or by the formation of reactive oxygen species that can indirectly affect DNA integrity. UVA radiation is emitted by lamps from everyday devices. In adult rats, micronucleated erythrocytes (MNE) are removed from the circulation by the spleen. However, in newborn rats, MNE have been observed in peripheral blood erythrocytes. The objective of this study was to use micronucleus tests to evaluate the DNA damage caused in newborn rats exposed to UVA light from three different types of UVA lamps obtained from commonly used devices: counterfeit detectors, insecticide devices, and equipment used to harden resins for artificial nails. Rat neonates were exposed to UVA lamps for 20min daily for 6days. The neonates were sampled every third day, and the numbers of MNE and micronucleated polychromatic erythrocytes (MNPCE) in the peripheral blood were determined. The rat neonates exposed to the three types of UVA lamps showed increased numbers of MNE and MNPCE from 48h to 144h (P0.05 and P0.001 respectively). However, no relationship was observed between the number of MNE and the wattage of the lamps. In conclusion, under these conditions, UVA light exposure induced an increase in MNE without causing any apparent damage to the skin.

Ultraviolet-A Light Induces Micronucleated Erythrocytes in Newborn Rats Ultraviolet-A (UV-A) light induce DNA damage by creating pyrimidine dimers, or indirectly affects DNA by the formation of reactive oxygen species. The objective was to determine DNA damage by micronucleus test in neonatal rats exposed to UV-A light. Rat neonates were exposed to light from a LED lamp (control group), to UV-C light 254 nm (control group to desquamation skin) or UV-A light 365 nm and in one group the dams were supplemented with folic acid (FA), to determine micronucleated erythrocytes (MNE) and micronucleated polychromatic erythrocytes (MNPCE) in peripheral blood of offspring.

Resumen Presentamos el caso de una mujer de 80 anos con hepatopatia cronica secundaria a infeccion por virus de la hepatitis C (VHC) y linfoma primario marginal esplenico. Ingreso por episodios de descompensacion cardiaca siendo exitus por insuficiencia respiratoria. Se le diagnostico crioglobulinemia mixta tipo II asociada a infeccion por VHC debido a la presencia de crioglobulinas en sangre. El estudio necropsico revelo hallazgos cutaneos y renales compatibles con esta entidad y determino la presencia de infiltracion de diferentes organos por linfoma. La causa de muerte fue una hemorragia alveolar pulmonar bilateral masiva. La crioglobulinemia mixta asociada a virus de la hepatitis C (CMVHC) es una entidad reconocida que puede presentar complicaciones, entre las que destacan la afectacion renal y la pulmonar. La hemorragia pulmonar es una de las complicaciones mas graves, con un alto indice de mortalidad.

Late infantile neuronal ceroid lipofuscinosis (Jansky-Bielchowsky disease) is a rare disease caused by mutations in the CLN2 gene. The authors report the clinical outcome and correlate with genotype in 12 Spanish patients with this disease. Psychomotor regression, epilepsy, and other clinical symptoms/signs were assessed. Age at onset of clinical symptoms ranged from 18 months to 3.7 years, and they included delayed speech and simple febrile seizures followed by epilepsy. Partial seizures and myoclonic jerks occurred at an earlier age (median 3.4 and 3.7 years, respectively) than ataxia and cognitive decline (median 4 years). Clinical regression was initiated by loss of sentences (median 3.7 years) followed by loss of walking ability and absence of language (median 4.5 years). Patients showed blindness and lost sitting ability at similar age (median 5 years). The authors report 4 novel mutations in the CLN2 gene. This study provides detailed information about the natural history of this disease.

Pregnant hairless rat dams were exposed to ultraviolet-A light (UVA) to induce micronucleated erythrocytes (MNE) in their fetuses. The control group was exposed to conventional light; the experimental groups were exposed to UVA (365 nm) during gestational days 16–21. In some cases, ascorbic acid (Asc) was administered in the drinking water from gestational day 15 until delivery. Dams were sampled at 48-h intervals during gestation, from day 16 until delivery. Blood was also obtained from neonates at birth; MNE, micronucleated polychromatic erythrocytes (MNPCE), and polychromatic erythrocytes (PCE) were scored. Increased MNE and MNPCE were observed in neonates born to mothers exposed to UVA for 40, 80 or 160 min, compared to the control group. Asc treatment reduced MNE and MNPCE induction.

El desarrollo de la web semántica, entendida como un espacio compartido para el intercambio de datos estructurados, ha supuesto un interés renovado por los lenguajes controlados tradicionales. Este estudio presenta una metodología evaluativa que posibilita el análisis sistemático de herramientas para la gestión de tesauros mediante la aplicación de un conjunto de criterios que tienen en cuenta el propósito, las funcionalidades de la aplicación, el mantenimiento de la integridad o coherencia del vocabulario, así como otras cuestiones cruciales referidas a la interoperabilidad, con especial atención a la compatibilidad con los estándares de la web semántica (RDF/SKOS), a la integración de estas herramientas en otros sistemas de información, la interoperabilidad de la información contenida o la habilidad para combinar tesauros procedentes de diferentes fuentes.

The presence of magnetic fields is an attractive hypothesis for shaping PNe. We report on observations of the central star of the two Planetary Nebulae NGC1360 and LSS1326. We performed spectroscopy on circularly polarized light with the FOcal Reducer and low dispersion Spectrograph at the Very Large Telescope of the European Southern Observatory. Contrary to previous reports (Jordan et al. 2005, A&A, 432, 273), we find that the effective magnetic field, that is the average over the visible stellar disk of longitudinal components of the magnetic fields, is null within errors for both stars. We conclude that a direct evidence of magnetic fields on the central stars of PNe is still missing --- either the magnetic field is much weaker (< 600 G) than previously reported, or more complex (thus leading to cancellations), or both. Certainly, indirect evidences (e.g., MASER emission) fully justify further efforts to study the strength and morphology of such magnetic fields., Published in ApJ letters: Leone et al. 2011, ApJ, 731, 33L

Herpes simplex encephalitis is the most common form of sporadic viral encephalitis. It may occur at any age, giving rise to a syndrome with a high morbidity and mortality. Its presentation may be atypical, and the initial complementary investigations nonspecific, making early diagnosis difficult and thus worsening its prognosis. This report describes four infants with herpes encephalitis presenting with an opercular syndrome that left significant sequelae after the acute episode. The opercular syndrome is characterized clinically by a disturbance of voluntary control of the facio-linguo-glosso-pharyngeal muscles, affecting speech and swallowing. Recognition of the opercular syndrome as a form of presentation of herpes encephalitis enables early diagnosis to be made in these patients, with the rapid initiation of treatment with acyclovir, improving the clinical course.

Cavernous hemangioma is the most frequent focal liver lesion. It affects mainly women and may cause symptoms such as abdominal pain, mass, and early satiety, or complications such as heart failure or coagulopathy. There are several options for treatment in symptomatic patients. However, it seems that surgical resection is the only curative treatment.Evaluate indications and results of liver resection in patients with cavernous hemangiomas and hepatic hemangiomatosis.We conducted a retrospective analysis of clinical files of patients treated at the Instituto Nacional de Cancerología (INCan) and the Centro Médico ISSEMYM during a 8-year period. Epidemiological data as well as diagnostic work-up and treatment were analyzed.From August 1995 to May 2003, 24 patients with liver hemangiomas were resected at both institutions. Twenty three were female (95.8%) and one, male (4.1%). Indications for surgery were presence of symptoms in 20 patients (83.3%), undefined diagnosis in three (12.5%), and rapid growth in one (4.1%). Most frequent symptoms were abdominal pain in 20 (83.3%) patients, followed by abdominal mass in five (20.8%), and early gastric satiety in four (16.6%). Abdominal computed tomography (CT) scan was the most frequent imaging study used in 22 patients (91.6%), followed by ultrasound in 20 (83.3%). Size of lesion ranged from 4-30 cm (X: 8.7 cm), 16 patients were submitted to formal liver resection (66.6%), and eight to enucleation (33.3%). Four patients presented operative complications (16.6%) that included postoperative bleeding in two (8.3%), fever in one (4.1%) and abdominal haematoma in one (4.1%). There was no operative mortality. Twenty two patients were asymptomatic at time of evaluation (91%).This lesion affects mainly women, and presence of symptoms is the most common indication for treatment. Choice of surgical procedure to be carried out depends on location and morphology of the lesion. Liver resection or enucleation are safe forms of treatment that properly controlled symptomatology.