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6. Beta Blockade Prevents Cardiac Morphological and Molecular Remodelling in Experimental Uremia.

Author

Chinnappa, Shanmugakumar, Maqbool, Azhar, Viswambharan, Hema, Mooney, Andrew, Denby, Laura, and Drinkhill, Mark

Subjects
*UREMIA, *CHRONIC kidney failure, *CARDIAC hypertrophy, *HEART failure, *TISSUE extracts
Abstract

Heart failure and chronic kidney disease (CKD) share several mediators of cardiac pathological remodelling. Akin to heart failure, this remodelling sets in motion a vicious cycle of progressive pathological hypertrophy and myocardial dysfunction in CKD. Several decades of heart failure research have shown that beta blockade is a powerful tool in preventing cardiac remodelling and breaking this vicious cycle. This phenomenon remains hitherto untested in CKD. Therefore, we set out to test the hypothesis that beta blockade prevents cardiac pathological remodelling in experimental uremia. Wistar rats had subtotal nephrectomy or sham surgery and were followed up for 10 weeks. The animals were randomly allocated to the beta blocker metoprolol (10 mg/kg/day) or vehicle. In vivo and in vitro cardiac assessments were performed. Cardiac tissue was extracted, and protein expression was quantified using immunoblotting. Histological analyses were performed to quantify myocardial fibrosis. Beta blockade attenuated cardiac pathological remodelling in nephrectomised animals. The echocardiographic left ventricular mass and the heart weight to tibial length ratio were significantly lower in nephrectomised animals treated with metoprolol. Furthermore, beta blockade attenuated myocardial fibrosis associated with subtotal nephrectomy. In addition, the Ca++- calmodulin-dependent kinase II (CAMKII) pathway was shown to be activated in uremia and attenuated by beta blockade, offering a potential mechanism of action. In conclusion, beta blockade attenuated hypertrophic signalling pathways and ameliorated cardiac pathological remodelling in experimental uremia. The study provides a strong scientific rationale for repurposing beta blockers, a tried and tested treatment in heart failure, for the benefit of patients with CKD. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Biofuel production potential of indigenous isolates of Scenedesmus sp. from lake water in Pakistan.

Author

Najeeb, Muhammad Imran, Ahmad, Mansur-ud-Din, Anjum, Aftab Ahmad, Maqbool, Azhar, Ali, Muhammad Asad, Nawaz, Muhammad, Ali, Tehreem, and Manzoor, Rabia

Subjects
BIOMASS energy, SCENEDESMUS, CHLOROFORM, LINOLEIC acid
Abstract

Aims: This paper presents the report on biodiesel and biogas production at a laboratory scale from Scenedesmus strain. Methodology and results: Previously isolated and identified Scenedesmus were grown in 10 Liter flask using BG-11 media at 16 h light and 8 h dark cycle. Oven-dried biomass (20 g) from 16-day-old culture of Scenedesmus was finely grounded and subjected to lipids extraction by chloroform-methanol-NaCl mixture. Microalgal lipids (6 mL) were subjected to transesterification by using NaOH leading to the production of 5 mL biodiesel and 4 mL of glycerin. Biodiesel was rich in methyl esters of linoleic acid, phosphorothioc acid and dodecanoic acid, as shown by gas chromatography-mass spectrometry (GC-MS) analysis. Oven-dried microalgae (2 g) without lipid extraction and leftover biomass (2 g) after lipid extraction were subject to biogas production through anaerobic digestion. Biogas (34, 27 and 19 mL) were recorded respectively in oven-dried whole biomass; lipid extracted biomass and control over a period of 15 days of anaerobic digestion. Conclusion, significance and impact of study: It was concluded that water bodies are rich in diverse algae, especially Scenedesmus sp., and this algae can be cultured to produce biodiesel and biogas. But the lipid accumulation potential of microalgae requires special treatment and lipid extraction methods are not up to the mark, which is a major bottleneck in biofuel production from microalgae. [ABSTRACT FROM AUTHOR]

Published
2022
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17. Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance related vascular damage. Supplemental Material. Maqbool et al 2020

Author

Maqbool, Azhar

Subjects
urogenital system, cardiovascular system, lipids (amino acids, peptides, and proteins), hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology
Abstract

Supplemental Data consists of (a) Breeding and Genotyping Strategy(b) Genotyping Protocol, protocols for APOE PCR, ESMIRO PCR, Nox PCR (c) Details of Taqman Probes used(d) Data concerning metabolic phenotype of ESMIRO/ApoE-/-/Nox2-/y and ESMIRO/ApoE-/-/Nox2+/y mice(e) Data showing elastin fibre fragmentation(f) Data showing the effect of genetic ablation or pharmacological inhibition of Nox2 on Heavy Chain Myosin expression and alpha smooth muscle actin in aortas of mice(g) Data showing liver function and lipid deposition in ESMIRO/ApoE-/-/Nox2-/y and ESMIRO/ApoE-/-/Nox2+/y mice

Published
2020
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18. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Author

Burton, Paul R., Clayton, David G., Cardon, Lon R., Craddock, Nick, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P., McCarthy, Mark I., Ouwehand, Willem H., Samani, Nilesh J., Todd, John A., Donnelly, Peter, Barrett, Jeffrey C., Davison, Dan, Easton, Doug, Evans, David, Leung, Hin-Tak, Marchini, Jonathan L., Morris, Andrew P., Spencer, Chris C. A., Tobin, Martin D., Attwood, Antony P., Boorman, James P., Cant, Barbara, Everson, Ursula, Hussey, Judith M., Jolley, Jennifer D., Knight, Alexandra S., Koch, Kerstin, Meech, Elizabeth, Nutland, Sarah, Prowse, Christopher V., Stevens, Helen E., Taylor, Niall C., Walters, Graham R., Walker, Neil M., Watkins, Nicholas A., Winzer, Thilo, Jones, Richard W., McArdle, Wendy L., Ring, Susan M., Strachan, David P., Pembrey, Marcus, Breen, Gerome, St Clair, David, Caesar, Sian, Gordon-Smith, Katherine, Jones, Lisa, Fraser, Christine, Green, Elaine K., Grozeva, Detelina, Hamshere, Marian L., Holmans, Peter A., Jones, Ian R., Kirov, George, Moskvina, Valentina, Nikolov, Ivan, O'Donovan, Michael C., Owen, Michael J., Collier, David A., Elkin, Amanda, Farmer, Anne, Williamson, Richard, McGuffin, Peter, Young, Allan H., Ferrier, I. Nicol, Ball, Stephen G., Balmforth, Anthony J., Barrett, Jennifer H., Bishop, D. Timothy, Iles, Mark M., Maqbool, Azhar, Yuldasheva, Nadira, Hall, Alistair S., Braund, Peter S., Dixon, Richard J., Mangino, Massimo, Stevens, Suzanne, Thompson, John R., Bredin, Francesca, Tremelling, Mark, Parkes, Miles, Drummond, Hazel, Lees, Charles W., Nimmo, Elaine R., Satsangi, Jack, Fisher, Sheila A., Forbes, Alastair, Lewis, Cathryn M., Onnie, Clive M., Prescott, Natalie J., Sanderson, Jeremy, Mathew, Christopher G., Barbour, Jamie, Mohiuddin, M. Khalid, Todhunter, Catherine E., Mansfield, John C., Ahmad, Tariq, Cummings, Fraser R., Jewell, Derek P., Webster, John, Brown, Morris J., Lathrop, G. Mark, Connell, John, Dominiczak, Anna, Marcano, Carolina A. Braga, Burke, Beverley, Dobson, Richard, Gungadoo, Johannie, Lee, Kate L., Munroe, Patricia B., Newhouse, Stephen J., Onipinla, Abiodun, Wallace, Chris, Xue, Mingzhan, Caulfield, Mark, Farrall, Martin, Barton, Anne, Bruce, Ian N., Donovan, Hannah, Eyre, Steve, Gilbert, Paul D., Hider, Samantha L., Hinks, Anne M., John, Sally L., Potter, Catherine, Silman, Alan J., Symmons, Deborah P. M., Thomson, Wendy, Worthington, Jane, Dunger, David B., Widmer, Barry, Frayling, Timothy M., Freathy, Rachel M., Lango, Hana, Perry, John R. B., Shields, Beverley M., Weedon, Michael N., Hattersley, Andrew T., Hitman, Graham A., Walker, Mark, Elliott, Kate S., Groves, Christopher J., Lindgren, Cecilia M., Rayner, Nigel W., Timpson, Nicholas J., Zeggini, Eleftheria, Newport, Melanie, Sirugo, Giorgio, Lyons, Emily, Vannberg, Fredrik, Hill, Adrian V. S., Bradbury, Linda A., Farrar, Claire, Pointon, Jennifer J., Wordsworth, Paul, Brown, Matthew A., Franklyn, Jayne A., Heward, Joanne M., Simmonds, Matthew J., Gough, Stephen C. L., Seal, Sheila, Stratton, Michael R., Rahman, Nazneen, Ban, Maria, Goris, An, Sawcer, Stephen J., Compston, Alastair, Conway, David, Jallow, Muminatou, Rockett, Kirk A., Bumpstead, Suzannah J., Chaney, Amy, Downes, Kate, Ghori, Mohammed J. R., Gwilliam, Rhian, Hunt, Sarah E., Inouye, Michael, Keniry, Andrew, King, Emma, McGinnis, Ralph, Potter, Simon, Ravindrarajah, Rathi, Whittaker, Pamela, Widden, Claire, Withers, David, Cardin, Niall J., Ferreira, Teresa, Pereira-Gale, Joanne, Hallgrimsdottir, Ingileif B., Howie, Bryan N., Su, Zhan, Teo, Yik Ying, Vukcevic, Damjan, Bentley, David, and Compston, Alistair

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): The Wellcome Trust Case Control Consortium; Management Committee; Paul R. Burton [1]; David G. Clayton [2]; Lon R. Cardon [3]; Nick Craddock [4]; Panos Deloukas [5]; Audrey Duncanson [6]; [...]

Published
2007
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22. Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage

Author

Maqbool, Azhar, primary, Watt, Nicole T., additional, Haywood, Natalie, additional, Viswambharan, Hema, additional, Skromna, Anna, additional, Makava, Natalia, additional, Visnagri, Asjad, additional, Shawer, Heba M., additional, Bridge, Katherine, additional, Muminov, Shovkat K., additional, Griffin, Kathryn, additional, Beech, David J., additional, Wheatcroft, Stephen B., additional, Porter, Karen E., additional, Simmons, Katie J., additional, Sukumar, Piruthivi, additional, Shah, Ajay M., additional, Cubbon, Richard M., additional, Kearney, Mark T., additional, and Yuldasheva, Nadira Y., additional

Published
2020
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24. Fibroblast-specific deletion of IL-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction

Author

Bageghni, Sumia A., Hemmings, Karen E., Yuldasheva, Nadira Y., Maqbool, Azhar, Gamboa-Esteves, Filomena O., Humphreys, Neil E., Jackson, Maj Simonsen, Denton, Christopher P., Francis, Sheila, Porter, Karen E., Ainscough, Justin F.X., Pinteaux, Emmanuel, Drinkhill, Mark J., and Turner, Neil A.

Subjects
Inflammation, Heart Failure, Male, Mice, Knockout, Receptors, Interleukin-1 Type I, Ventricular Remodeling, Myocardium, Cardiology, Myocardial Infarction, Fibroblasts, Fibrosis, Disease Models, Animal, Mice, Interleukin-1alpha, Cytokines, Animals, Myocytes, Cardiac, Research Article, Signal Transduction
Abstract

It has been hypothesized that IL-1α is released from damaged cardiomyocytes following myocardial infarction (MI) and activates cardiac fibroblasts via its receptor (IL-1R1) to drive the early stages of cardiac remodeling. This study aimed to definitively test this hypothesis using cell type–specific IL-1α and IL-1R1–KO mouse models. A floxed Il1a mouse was created and used to generate a cardiomyocyte-specific IL-1α–KO (MIL1AKO) mouse line. A tamoxifen-inducible fibroblast-specific IL-1R1 hemizygous KO (FIL1R1KO) mouse line was also generated. Mice underwent experimental MI (permanent left anterior descending coronary artery ligation), and cardiac function was determined 4 weeks later by conductance pressure-volume catheter analysis. Molecular markers of remodeling were evaluated at various time points by real-time RT-PCR and histology. MIL1AKO mice showed no difference in cardiac function or molecular markers of remodeling after MI compared with littermate controls. In contrast, FIL1R1KO mice showed improved cardiac function and reduced remodeling markers after MI compared with littermate controls. In conclusion, these data highlight a key role for the IL-1R1/cardiac fibroblast signaling axis in regulating remodeling after MI and provide support for the continued development of anti–IL-1 therapies for improving cardiac function after MI. Cardiomyocyte-derived IL-1α was not an important contributor to remodeling after MI in this model., Fibroblast-specific knockout of IL-1R1, but not cardiomyocyte-specific knockout of IL-1α, improved cardiac function and remodeling after myocardial infarction.

Published
2019

26. Prevalence and risk factors for IgG antibodies to Neospora spp. in three types of equids from Southern Punjab, Pakistan

Author

Nazir, Muhammad Mudasser, primary, Ayaz, Muhammad Mazhar, additional, Ahmed, Atif Nisar, additional, Rasheed, Imran, additional, Faraz, Asim, additional, Akram, Qaisar, additional, Akhtar, Saleem, additional, Maqbool, Azhar, additional, Tabassum, Shahida, additional, Zheng, Yadong, additional, and Lindsay, David S., additional

Published
2018
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27. Roost characteristics and habitat preferences of Indian flying fox(Pteropus giganteus) in urban areas of Lahore, Pakistan

Author

GULRAIZ, TAYIBA LATIF, JAVID, ARSHAD, MAHMOOD-UL-HASSAN, MUHAMMAD, MAQBOOL, AZHAR, ASHRAF, SANA, HUSSAIN, MAKHDOOM, and DAUD, SHAROON

Subjects
Tree height,diameter at breast height,bat roost,Jinnah garden,Indian flying fox,Pteropus giganteus,Mangifera indica, Animal Science and Zoology
Abstract

Roost characteristics of Indian flying fox Pteropus giganteus at the Jinnah (n = 1052) and Lalazar (n = 40) gardens in Lahore were observed for a period of 1 year to find roost preferences in these bats. The Jinnah garden harbors 4119 trees belonging to 46 families, 103 genera, and 132 species, of which 44 trees belonging to 17 families, 19 genera, and 21 species served as bat roosts. The Lalazar garden harbors 90 trees representing 7 families, 9 genera, and 9 species. Six of these belonging to 2 families, 2 genera, and 2 species each served as bat roosts. Height of the roosting trees varied from 7.5 m (Dendrocalamus hamiltonii) to 19.8 m (Celtis australis) and diameter at breast height (dbh) ranged from 0.10 m (Putranjiva roxburghii) to 0.89 m (Kigelia pinnata). Maximum average bats (n = 88) were roosting in P. roxburghii with total height of 13.4 m and dbh of 0.1 m, whereas minimum bats (n = 8) were observed on Manilkara hexandra having height of 14.4 m and dbh of 0.24 m. It can be concluded from the present study that P. giganteus prefers to roost near water bodies on tall trees with relatively smaller diameters.

Published
2015

29. Prevalence of Toxoplasma gondii, Neospora caninum, and Sarcocystis Species DNA in the Heart and Breast Muscles of Rock Pigeons (Columbia livia)

Author

Nazir, Muhammad Mudasser, primary, Ayaz, Muhammad Mazhar, additional, Ahmed, Atif Nisar, additional, Maqbool, Azhar, additional, Ashraf, Kamran, additional, Oneeb, Muhammad, additional, Yasin, Ghulam, additional, Subhani, Atta, additional, Ali, Muhammad Asif, additional, Nazir, Noman, additional, and Sajid, Muhammad Afzal, additional

Published
2018
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31. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

Author

Nejentsev, Sergey, Howson, Joanna M. M., Walker, Neil M., Szeszko, Jeffrey, Field, Sarah F., Stevens, Helen E., Reynolds, Pamela, Hardy, Matthew, King, Erna, Masters, Jennifer, Hulme, John, Maier, Lisa M., Smyth, Deborah, Bailey, Rebecca, Cooper, Jason D., Ribas, Gloria, Campbell, R. Duncan, Clayton, David G., Todd, John A., Burton, Paul R., Cardon, Lon R., Craddock, Nick, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P., McCarthy, Mark I., Ouwehand, Willem H., Samani, Nilesh J., Donnelly, Peter, Barrett, Jeffrey C., Davison, Dan, Easton, Doug, Evans, David, Leung, Hin-Tak, Marchini, Jonathan L., Morris, Andrew P., Spencer, Chris C. A., Tobin, Martin D., Attwood, Antony P., Boorman, James P., Cant, Barbara, Everson, Ursula, Hussey, Judith M., Jolley, Jennifer D., Knight, Alexandra S., Koch, Kerstin, Meech, Elizabeth, Nutland, Sarah, Prowse, Christopher V., Taylor, Niall C., Walters, Graham R., Watkins, Nicholas A., Winzer, Thilo, Jones, Richard W., McArdle, Wendy L., Ring, Susan M., Strachan, David P., Pembrey, Marcus, Breen, Gerome, St Clair, David, Caesar, Sian, Gordon-Smith, Katherine, Jones, Lisa, Fraser, Christine, Green, Elaine K., Grozeva, Detelina, Hamshere, Marian L., Holmans, Peter A., Jones, Ian R., Kirov, George, Moskvina, Valentina, Nikolov, Ivan, O'Donovan, Michael C., Owen, Michael J., Collier, David A., Elkin, Amanda, Farmer, Anne, Williamson, Richard, McGuffin, Peter, Young, Allan H., Nicol Ferrier, I., Ball, Stephen G., Balmforth, Anthony J., Barrett, Jennifer H., Bishop, D. Timothy, Iles, Mark M., Maqbool, Azhar, Yuldasheva, Nadira, Hall, Alistair S., Braund, Peter S., Dixon, Richard J., Mangino, Massimo, Stevens, Suzanne, Thompson, John R., Bredin, Francesca, Tremelling, Mark, Parkes, Miles, Drummond, Hazel, Lees, Charles W., Nimmo, Elaine R., Satsangi, Jack, Fisher, Sheila A., Forbes, Alastair, Lewis, Cathryn M., Onnie, Clive M., Prescott, Natalie J., Sanderson, Jeremy, Mathew, Christopher G., Barbour, Jamie, Khalid Mohiuddin, M., Todhunter, Catherine E., Mansfield, John C., Ahmad, Tariq, Cummings, Fraser R., Jewell, Derek P., Webster, John, Brown, Morris J., Lathrop, G. Mark, Connell, John, Dominiczak, Anna, Braga, Carolina A., Burke, Beverley, Dobson, Richard, Gungadoo, Johannie, Lee, Kate L., Munroe, Patricia B., Newhouse, Stephen J., Onipinla, Abiodun, Wallace, Chris, Xue, Mingzhan, Caulfield, Mark, Farrall, Martin, Barton, Anne, Bruce, Ian N., Donovan, Hannah, Eyre, Steve, Gilbert, Paul D., Hider, Samantha L., Hinks, Anne M., John, Sally L., Potter, Catherine, Silman, Alan J., Symmons, Deborah P. M., Thomson, Wendy, Worthington, Jane, Dunger, David B., Widmer, Barry, Frayling, Timothy M., Freathy, Rachel M., Lango, Hana, Perry, John R. B., Shields, Beverley M., Weedon, Michael N., Hattersley, Andrew T., Hitman, Graham A., Walker, Mark, Elliott, Kate S., Groves, Christopher J., Lindgren, Cecilia M., Rayner, Nigel W., Timpson, Nicholas J., Zeggini, Eleftheria, Newport, Melanie, Sirugo, Giorgio, Lyons, Emily, Vannberg, Fredrik, Hill, Adrian V. S., Bradbury, Linda A., Farrar, Claire, Pointon, Jennifer J., Wordsworth, Paul, Brown, Matthew A., Franklyn, Jayne A., Heward, Joanne M., Simmonds, Matthew J., Gough, Stephen C. L., Seal, Sheila, Stratton, Michael R., Rahman, Nazneen, Ban, Maria, Goris, An, Sawcer, Stephen J., Compston, Alastair, Conway, David, Jallow, Muminatou, Rockett, Kirk A., Bryan, Claire, Bumpstead, Suzannah J., Chaney, Amy, Downes, Kate, Ghori, Jilur, Gwilliam, Rhian, Hunt, Sarah E., Inouye, Michael, Keniry, Andrew, King, Emma, McGinnis, Ralph, Potter, Simon, Ravindrarajah, Rathi, Whittaker, Pamela, Withers, David, Cardin, Niall J., Ferreira, Teresa, Pereira-Gale, Joanne, Hallgrimsdottir, Ingeleif B., Howie, Bryan N., Su, Zhan, Ying Teo, Yik, Vukcevic, Damjan, Bentley, David, and Compston, Alistair

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Sergey Nejentsev [1, 57]; Joanna M. M. Howson (corresponding author) [1, 57]; Neil M. Walker [1]; Jeffrey Szeszko [1]; Sarah F. Field [1]; Helen E. Stevens [1]; Pamela Reynolds [...]

Published
2007
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33. Chemotherapy of Coccidiosis in Calves

Author

Sultana, Razia, primary, Ilyas, Shabnum CH, additional, Maqbool, Azhar, additional, Iqbal, Zafar CH, additional, Ahmad, Mansur-ud-Din, additional, and Ahmad, Zahid M, additional

Published
2017
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34. Affimer proteins are versatile and renewable affinity reagents

Author

Tiede, Christian, primary, Bedford, Robert, additional, Heseltine, Sophie J, additional, Smith, Gina, additional, Wijetunga, Imeshi, additional, Ross, Rebecca, additional, AlQallaf, Danah, additional, Roberts, Ashley PE, additional, Balls, Alexander, additional, Curd, Alistair, additional, Hughes, Ruth E, additional, Martin, Heather, additional, Needham, Sarah R, additional, Zanetti-Domingues, Laura C, additional, Sadigh, Yashar, additional, Peacock, Thomas P, additional, Tang, Anna A, additional, Gibson, Naomi, additional, Kyle, Hannah, additional, Platt, Geoffrey W, additional, Ingram, Nicola, additional, Taylor, Thomas, additional, Coletta, Louise P, additional, Manfield, Iain, additional, Knowles, Margaret, additional, Bell, Sandra, additional, Esteves, Filomena, additional, Maqbool, Azhar, additional, Prasad, Raj K, additional, Drinkhill, Mark, additional, Bon, Robin S, additional, Patel, Vikesh, additional, Goodchild, Sarah A, additional, Martin-Fernandez, Marisa, additional, Owens, Ray J, additional, Nettleship, Joanne E, additional, Webb, Michael E, additional, Harrison, Michael, additional, Lippiat, Jonathan D, additional, Ponnambalam, Sreenivasan, additional, Peckham, Michelle, additional, Smith, Alastair, additional, Ferrigno, Paul Ko, additional, Johnson, Matt, additional, McPherson, Michael J, additional, and Tomlinson, Darren Charles, additional

Published
2017
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35. Author response: Affimer proteins are versatile and renewable affinity reagents

Author

Tiede, Christian, primary, Bedford, Robert, additional, Heseltine, Sophie J, additional, Smith, Gina, additional, Wijetunga, Imeshi, additional, Ross, Rebecca, additional, AlQallaf, Danah, additional, Roberts, Ashley PE, additional, Balls, Alexander, additional, Curd, Alistair, additional, Hughes, Ruth E, additional, Martin, Heather, additional, Needham, Sarah R, additional, Zanetti-Domingues, Laura C, additional, Sadigh, Yashar, additional, Peacock, Thomas P, additional, Tang, Anna A, additional, Gibson, Naomi, additional, Kyle, Hannah, additional, Platt, Geoffrey W, additional, Ingram, Nicola, additional, Taylor, Thomas, additional, Coletta, Louise P, additional, Manfield, Iain, additional, Knowles, Margaret, additional, Bell, Sandra, additional, Esteves, Filomena, additional, Maqbool, Azhar, additional, Prasad, Raj K, additional, Drinkhill, Mark, additional, Bon, Robin S, additional, Patel, Vikesh, additional, Goodchild, Sarah A, additional, Martin-Fernandez, Marisa, additional, Owens, Ray J, additional, Nettleship, Joanne E, additional, Webb, Michael E, additional, Harrison, Michael, additional, Lippiat, Jonathan D, additional, Ponnambalam, Sreenivasan, additional, Peckham, Michelle, additional, Smith, Alastair, additional, Ferrigno, Paul Ko, additional, Johnson, Matt, additional, McPherson, Michael J, additional, and Tomlinson, Darren Charles, additional

Published
2017
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37. Mycoplasma gallisepticum modifies virus shedding and immune response of Newcastle disease virus in broilers.

Author

Qamar-un-Nisa, Younus, Muhammad, Khan, Muti-ur-Rehman, Maqbool, Azhar, and Umar, Sajid

Subjects
NEWCASTLE disease virus, VIRAL shedding, MYCOPLASMA gallisepticum, BIRD food, IMMUNE response, POULTRY farms, BROILER chickens, POULTRY industry
Abstract

Respiratory diseases are responsible for major economic losses in poultry farms. Newcastle disease virus (NDV) infections cause huge economic losses in poultry industry especially in the presence of other co-infecting pathogens. The purpose of this study was to assess the less understood effect of Mycoplasma gallisepticum (MG) on the replication and immune responses of NDV in broiler chicken. Three-week-old commercial broiler chickens were inoculated with either NDV, MG or both etiological agents. The experimental groups were identified as follows: negative control (Group C), Mycoplasma challenged (Group M), NDV challenged (Group V) and virus and Mycoplasma challenged (Group V+M). Blood samples and swabs were collected on daily basis for two weeks. All infected birds showed positive results for NDV shedding, however, the pattern of virus shedding was different, with birds of the group V+M showing more pronounced virus shedding than the birds in the group V. In addition, birds of V+M group showed significant reduction in anti-AI antibody responses and interferon gene expression than the birds in the V group. The present study revealed that MG could facilitate replication of NDV by bringing alterations in immune responses. [ABSTRACT FROM AUTHOR]

Published
2019
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42. Pathological Alterations during Co-Infection of Newcastle Disease Virus with Escherichia coli in Broiler Chicken.

Author

Qamar-un-Nisa, Younus, Muhammad, Muti-ur-Rehman, Maqbool, Azhar, Khan, Iahtasham, and Umar, Sajid

Abstract

Respiratory diseases are responsible for major economic losses at poultry farms especially during during co-infections of respiratory pathogens. However, impact of co-infections is not well known, especially in broilers. The current study was aimed to assess the probable synergism of E. coli (O78) and velogenic Newcastle disease virus (vNDV-CK-Pakistan-NARC-13N39-2013), in the broiler model. Three-week-old commercial broilers were inoculated with either vNDV, E. coli serotype O78 or both agents simultaneously or 3 days apart. The birds were clinically observed and swabbed daily. They were killed at 4 and 14 days after single or dual inoculations and were inspected for gross lesions. Samples of the respiratory organs (trachea, lungs, and air sacs) were taken for histological analyses. All the infected subjects showed clinical signs of varying severity. Co-infected groups showed the most obvious clinical signs, associated with significant higher mortality and respiratory organ abnormalities, in comparison with the monoinfected groups (P<0.05). There was a non-significant (P>0.05) effect of the inoculation time intervals between vNDV and E. coli inoculation (none or 3 days). Microscopic lesions staining supported clinical and macroscopic findings. Higher virus shedding (P<0.05) in oropharyngeal swabs was observed in coinfected groups than single infected groups. The results revealed that experimental co-infection of E. coli and NDV enhances the degree of severity of clinical signs, gross lesions and death rate and warns that E. coli and NDV can cause substantial economic losses by exercising additive or synergistic pathogenic effect in the reproduction of respiratory disease if given simultaneously or three days apart. [ABSTRACT FROM AUTHOR]

Published
2017
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43. Prevalence ofEntamoeba histolytica-Like Cysts Compared toE. histolyticaAntigens Detected by ELISA in the Stools of 600 Patients from Three Socioeconomic Communities in the Metropolitan City of Lahore, Pakistan

Author

Alam, Muhammad Azhar, primary, Maqbool, Azhar, additional, Nazir, Muhammad Mudasser, additional, Lateef, Muhammad, additional, Khan, Muhammad Sarwar, additional, Ahmed, Atif Nisar, additional, Ziaullah, M., additional, and Lindsay, David S., additional

Published
2015
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44. Trivalent Gd-DOTA reagents for modification of proteins

Author

Fisher, Martin J., primary, Williamson, Daniel J., additional, Burslem, George M., additional, Plante, Jeffrey P., additional, Manfield, Iain W., additional, Tiede, Christian, additional, Ault, James R., additional, Stockley, Peter G., additional, Plein, Sven, additional, Maqbool, Azhar, additional, Tomlinson, Darren C., additional, Foster, Richard, additional, Warriner, Stuart L., additional, and Bon, Robin S., additional

Published
2015
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47. PREVALENCE AND CHEMOTHERAPY OF TRICHOSTRONGYLOIDS IN CAMELS IN CHARSADA.

Author

QASIM, MUHAMMAD, MAQBOOL, AZHAR, IJAZ, MUHAMMAD, AHMAD, ABRAR, and DYAB, AHMED

Subjects
*STRONGYLIDA, *NEMATODE infections, *CAMEL diseases, *SAUSSUREA, *ALBENDAZOLE
Abstract

The prevalence of Ttrichostrongyloids among camels in Charsada district was measured and trials conducted to determine the efficacy of Saussurea lappa and Fumaria parviflora and Albendazole. 500 camels were examined, and trichostrongyloids were observed in 175 (35%). Haemonchos longisteps was the most predominant specie with the prevalence of (52.57%), followed by Trichostrongylus probolurus, Ostertagia Ostertagi, Dictyocaulus and Nematodirus dromedari being10.85%, 9.71%, 9.14% and 9.14% respectively. Cooperia was found to be the least prevalent 8.57% parasite. Young animals were found to be at higher risk of infection than adult animals. The efficacy of Saussurea lappa was 65.85%, Fumaria parviflora was 46.34, and albendazole was (66.66%) at one dose. Whereas the efficacy after second dose was of Saussurea lappa (85.36%), Fumaria parviflora was (82.92 %), and albendazole was (97.4 3%). Making albendazole is the most effective treatment against trichostrongyloids in camels. [ABSTRACT FROM AUTHOR]

Published
2017
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48. EFFECTS OF ASCORBIC ACID AND ACETYLSALICYLIC ACID SUPPLEMENTATION ON THE PERFORMANCE OF BROILER CHICKS EXPOSED TO HEAT STRESS

Author

Anwar, Bilal, Khan, Shakil Akhtar, Aslam, Asim, Maqbool, Azhar, Khan, Kashif Aziz, and Khan, Kashif Aziz

Subjects
heat stress, chicks, animal structures, [SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, Ascorbic acid, chemical and pharmacologic phenomena, acetylsalicylic acid
Abstract

A total of 100, day-old broiler chicks were randomly divided into 5 equal groups and kept under elevated temperature (93-97°F) to see the effect of ascorbic acid and acetylsalicylic acid on the feed conversion ratio (FCR), immune status and ratio of weight of bursa, thymus and spleen to body weight. Heat stress increased the FCR but decreased the immune response and ratio of bursa, thymus and spleen to body weight of the birds. Ascorbic acid and acetylsalicylic acid supplementation during heat stress had beneficial effects on FCR, immune status and ratio of bursa, thymus and spleen to body weight. Grossly, bursa, thymus and spleen of heat stressed birds were atrophied but in ascorbic acid and acetylsalicylic acid supplemented birds these organs were not atrophied. No specific histopathological changes were observed in all groups

Published
2004

50. Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms

Author

Riches, Kirsten, primary, Franklin, Larissa, additional, Maqbool, Azhar, additional, Peckham, Michelle, additional, Adams, Matthew, additional, Bond, Jacquelyn, additional, Warburton, Philip, additional, Feric, Nicole T., additional, Koschinsky, Marlys L., additional, O’Regan, David J., additional, Ball, Stephen G., additional, Turner, Neil A., additional, and Porter, Karen E., additional

Published
2013
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