Search

Your search keyword '"Mapley, Bethany"' showing total 7 results
Start Over Author "Mapley, Bethany"
7 results on '"Mapley, Bethany"'

1. Poly(2‐Hydroxyethyl Methacrylate) Hydrogel‐Based Microneedles for Metformin Release

Author

Sharma, Manoj B., primary, Kap, Özlem, additional, Abdelmohsen, Hend A. M., additional, Ashton, Mark D., additional, Harper, Garry R., additional, Firlak, Melike, additional, Aaltonen, Jasmine E., additional, Bolland, Kerry A., additional, Bragg, Ryan, additional, Deeley, Sarah, additional, Francis, Ella, additional, Kazi, Nahin, additional, Mapley, Bethany L., additional, Oikonomou, Vasileios, additional, Aljohani, Amal D., additional, Cheneler, David, additional, Kilic, Volkan, additional, Horzum, Nesrin, additional, and Hardy, John G., additional

Published
2023
Full Text
View/download PDF

2. Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release

Author

Sharma, Manoj, Kap, Özlem, Abdelmohsen, Hend, Ashton, Mark, Harper, Garry, Firlak, Melike, Aaltonen, Jasmine, Bolland, Kerry, Bragg, Ryan, Deeley, Sarah, Francis, Ella, Kazi, Nahin, Mapley, Bethany, Oikonomou, Vasileios, Aljohani, Amal Dhaifallah, Cheneler, David, Kılıç, Volkan, Horzum, Nesrin, and Hardy, John

Abstract

The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature-dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.

Published
2023
Full Text
View/download PDF

3. Polymer hydrogel-based microneedles for metformin release

Author

Sharma, Manoj, Kap, Özlem, Abdelmohsen, Hend, Harper, Garry, Firlak, Melike, Aaltonen, Jasmine, Bolland, Kerry, Bragg, Ryan, Deeley, Sarah, Francis, Ella, Kazi, Nahin, Mapley, Bethany, Oikonomou, Vasileios, Aljohani, Amal, Halcovitch, Nathan, Cheneler, David, Kılıç, Volkan, Horzum, Nesrin, Hardy, John, Sharma, Manoj, Kap, Özlem, Abdelmohsen, Hend, Harper, Garry, Firlak, Melike, Aaltonen, Jasmine, Bolland, Kerry, Bragg, Ryan, Deeley, Sarah, Francis, Ella, Kazi, Nahin, Mapley, Bethany, Oikonomou, Vasileios, Aljohani, Amal, Halcovitch, Nathan, Cheneler, David, Kılıç, Volkan, Horzum, Nesrin, and Hardy, John

Abstract

Drug delivery devices ensure the effective delivery of a broad range of therapeutics to millions of patients worldwide on a daily basis.1 Microneedles are a class of drug delivery device that provide pain free transdermal delivery with improved patient compliance.2-4 The release of metformin, a drug used in the treatment of cancer and diabetes, from polymer hydrogel-based microneedle patches was demonstrated in vitro. Tuning the composition of the polymer hydrogels enabled preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ca. 40 N). Swelling experiments conducted at 20°C, 35°C and 60°C show temperature dependent degrees of swelling and kinetics (Fickian diffusion). Drug release from the hydrogel-based microneedles was fitted to various models (e.g., zero order, first order, second order, Korsmeyer-Peppas, Peppas-Sahlins), observing the best fit for the zero-order model. Such microneedles have potential application for transdermal delivery of metformin for the treatment of cancer and diabetes.

Published
2022

4. 19F Solid-State NMR and Vibrational Raman Characterization of Corticosteroid Drug-Lipid Membrane Interactions

Author

Mapley, Bethany, Townsend, David, Griffin, John, Ashton, Lorna, and Middleton, David

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

Drug interactions with phospholipid bilayers underpin their behaviour in cell membranes and in liposomal delivery formulations. Liposomal drug delivery in ocular medicine can overcome the physical barriers of the eye and better enable the active molecule to reach its target. Here, Raman and 19F solid-state NMR spectroscopy are used to characterise the interactions of two ocular corticosteroid drugs, difluprednate (DFP) and fluorometholone (FML), with multilamellar vesicles of phosphatidylcholine (PC). 31P NMR confirms that the lipid bilayer tolerates a high drug concentration (a drug: lipid molar ratio of 1 : 10). The 19F NMR spectra of the drugs in lipid bilayers reveal that FML and DFP have different average orientations within the lipid bilayer. Raman spectra of dried lipid films reveal that PC separates from DFP but not from FML, the less lipophilic of the two drugs. This combined approach will assist the design of, and inform the development of, improved liposomal preparations.

Published
2021
Full Text
View/download PDF

6. 19F Solid‐State NMR and Vibrational Raman Characterization of Corticosteroid Drug‐Lipid Membrane Interactions.

Author

Mapley, Bethany, Townsend, David, Griffin, John, Ashton, Lorna, and Middleton, David A.

Subjects
*CORTICOSTEROIDS, *BILAYER lipid membranes, *RAMAN spectroscopy, *CELL membranes, *NUCLEAR magnetic resonance spectroscopy, *PHOSPHOLIPIDS
Abstract

Drug interactions with phospholipid bilayers underpin their behaviour in cell membranes and in liposomal delivery formulations. Liposomal drug delivery in ocular medicine can overcome the physical barriers of the eye and better enable the active molecule to reach its target. Here, Raman and 19F solid‐state NMR spectroscopy are used to characterise the interactions of two ocular corticosteroid drugs, difluprednate (DFP) and fluorometholone (FML), with multilamellar vesicles of phosphatidylcholine (PC). 31P NMR confirms that the lipid bilayer tolerates a high drug concentration (a drug: lipid molar ratio of 1 : 10). The 19F NMR spectra of the drugs in lipid bilayers reveal that FML and DFP have different average orientations within the lipid bilayer. Raman spectra of dried lipid films reveal that PC separates from DFP but not from FML, the less lipophilic of the two drugs. This combined approach will assist the design of, and inform the development of, improved liposomal preparations. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

7. 19 F Solid-State NMR and Vibrational Raman Characterization of Corticosteroid Drug-Lipid Membrane Interactions.

Author

Mapley B, Townsend D, Griffin J, Ashton L, and Middleton DA

Subjects
Adrenal Cortex Hormones, Drug Interactions, Magnetic Resonance Spectroscopy, Lipid Bilayers, Pharmaceutical Preparations
Abstract

Drug interactions with phospholipid bilayers underpin their behaviour in cell membranes and in liposomal delivery formulations. Liposomal drug delivery in ocular medicine can overcome the physical barriers of the eye and better enable the active molecule to reach its target. Here, Raman and 19 F solid-state NMR spectroscopy are used to characterise the interactions of two ocular corticosteroid drugs, difluprednate (DFP) and fluorometholone (FML), with multilamellar vesicles of phosphatidylcholine (PC). 31 P NMR confirms that the lipid bilayer tolerates a high drug concentration (a drug: lipid molar ratio of 1 : 10). The 19 F NMR spectra of the drugs in lipid bilayers reveal that FML and DFP have different average orientations within the lipid bilayer. Raman spectra of dried lipid films reveal that PC separates from DFP but not from FML, the less lipophilic of the two drugs. This combined approach will assist the design of, and inform the development of, improved liposomal preparations., (© 2021 The Authors. ChemPlusChem published by Wiley-VCH GmbH.)

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results