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375 results on '"Mao, Yuxiang"'

7. Structurally divergent and recurrently mutated regions of primate genomes

Author

Mao, Yafei, Harvey, William T., Porubsky, David, Munson, Katherine M., Hoekzema, Kendra, Lewis, Alexandra P., Audano, Peter A., Rozanski, Allison, Yang, Xiangyu, Zhang, Shilong, Yoo, DongAhn, Gordon, David S., Fair, Tyler, Wei, Xiaoxi, Logsdon, Glennis A., Haukness, Marina, Dishuck, Philip C., Jeong, Hyeonsoo, del Rosario, Ricardo, Bauer, Vanessa L., Fattor, Will T., Wilkerson, Gregory K., Mao, Yuxiang, Shi, Yongyong, Sun, Qiang, Lu, Qing, Paten, Benedict, Bakken, Trygve E., Pollen, Alex A., Feng, Guoping, Sawyer, Sara L., Warren, Wesley C., Carbone, Lucia, and Eichler, Evan E.

Published
2024
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22. Three vs 6 Cycles of Chemotherapy for High-Risk Retinoblastoma: A Randomized Clinical Trial.

Author

Ye, Huijing, Xue, Kang, Zhang, Ping, Chen, Rongxin, Zhai, Xiaowen, Ling, Li, Xiao, Wei, Tang, Lijuan, Wang, Hongsheng, Mao, Yuxiang, Ai, Siming, Bi, Yingwen, Liu, Qing, Zou, Yusha, Qian, Jiang, and Yang, Huasheng

Subjects
CLINICAL trials, RETINOBLASTOMA, ADJUVANT chemotherapy, CANCER chemotherapy, PROGRESSION-free survival
Abstract

Key Points: Question: Is the long-term efficacy of adjuvant 3-cycle carboplatin, etoposide, and vincristine (CEV) regimen considered noninferior to the standard 6-cycle CEV regimen in patients with pathologically high-risk retinoblastoma? Findings: In this noninferiority randomized clinical trial of 187 patients with a median follow-up of 79.0 months, 5-year disease-free survival for patients receiving 3-cycle and 6-cycle CEV was 90.4% and 89.2%, respectively. The difference met the noninferiority margin criterion of 12%. Meaning: A 3-cycle CEV regimen demonstrated noninferiority compared with a 6-cycle approach and was and proved to be an efficacious adjuvant chemotherapy regimen for individuals diagnosed with pathologically high-risk retinoblastoma. Importance: Adjuvant therapy is an important and effective treatment for retinoblastoma. However, there is a lack of head-to-head clinical trials comparing 3 vs 6 cycles of CEV chemotherapy (carboplatin, etoposide, and vincristine) for enucleated unilateral retinoblastoma with high-risk pathological features. Objective: To assess whether 3 cycles of CEV chemotherapy is noninferior to 6 cycles for enucleated unilateral retinoblastoma with high-risk pathological features. Design, Setting, and Participants: This double-center, randomized, open-label, noninferiority trial was conducted at 2 premier eye centers in China and included 187 patients who had undergone enucleation for unilateral retinoblastoma with high-risk pathological features (massive choroidal infiltration, retrolaminar optic nerve invasion, or scleral infiltration) between August 2013 and March 2024. The final date of follow-up was March 21, 2024. Interventions: Patients were randomly assigned to receive either 3 (n = 94) or 6 (n = 93) cycles of CEV chemotherapy regimen after enucleation. Main Outcomes and Measures: The primary end point was disease-free survival, with a noninferiority margin of 12%. Secondary end points encompassed overall survival, safety, economic burden, and the quality of life of children. Results: All 187 patients (median [IQR] age, 25.0 [20.0-37.0] months; 83 [44.4%] female) completed the trial. Median (IQR) follow-up was 79.0 (65.5-102.5) months. Five-year disease-free survival was 90.4% for the 3-cycle group vs 89.2% for the 6-cycle group (difference, 1.2% [95% CI, −7.5% to 9.8%]), which met the noninferiority criterion (P =.003 for noninferiority). The 6-cycle group experienced a higher frequency of adverse events, greater reduction in quality of life scores, and increased costs compared with the 3-cycle group. Conclusions and Relevance: Among patients with unilateral pathologic high-risk retinoblastoma, 3 cycles of CEV chemotherapy resulted in 5-year disease-free survival that was noninferior to 6 cycles of CEV chemotherapy. Trial Registration: ClinicalTrials.gov Identifier: NCT01906814 This randomized clinical trial examines whether 3 cycles of carboplatin, etoposide, and vincristine chemotherapy is noninferior to 6 cycles for enucleated unilateral retinoblastoma with high-risk pathological features. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Carotenoid and Phenolic Compositions and Antioxidant Activity of 23 Cultivars of Corn Grain and Corn Husk Extract.

Author

Cai, Shaokai, Mao, Yuxiang, Gu, Yongjian, Huang, Bowen, He, Zhiyong, Zeng, Maomao, Wang, Zhaojun, Chen, Qiuming, Tang, Mingxia, and Chen, Jie

Subjects
FERULIC acid, PHENOLS, FUNCTIONAL foods, BIOACTIVE compounds, ZEAXANTHIN, CAROTENOIDS, LUTEIN
Abstract

As a byproduct of corn processing, corn husk is usually burned or disposed of. To make a better use of corn husk, its bioactive components need to be further explored. In this work, the carotenoids and phenolics of the extracts from the corn grain and corn husk of 15 different yellow corn and 8 different waxy corn were identified and quantified, and their antioxidant activities were assessed. The results showed many considerable variations in carotenoid contents. Four types of carotenoids were observed only in both yellow corn and black waxy corn. The highest lutein and zeaxanthin contents were both observed in yellow corn husks. Lutein dominates in yellow corn, ranging from 494.5 μg/g dw to 2870.8 μg/g dw, which is followed by zeaxanthin, ranging from 63.0 μg/g dw to 360.2 μg/g dw, and finally β-cryptoxanthin and β-carotene. The total content of polyphenols (TPC) and flavonoids (TFC) of the husk from 13 yellow corn cultivars, as well as the TPC of husk from 8 waxy corn cultivars, were all higher than those of their corn grain, with the highest TPC found in waxy corn husk. Additionally, a total of 20 phenolic compounds were identified, and ferulic acid showed the highest content and reached 1101.9 µg/g dw in a waxy corn husk. The average antioxidant activity of a waxy corn husk was 25–65% higher than that of a yellow corn husk, and the highest values were observed in the husk of the waxy corn cultivar Huhong 1. These results suggested that corn husk is a rich source of lutein and phenolics and provided excellent cultivars as a reference for functional food products in agriculture and the food industry. [ABSTRACT FROM AUTHOR]

Published
2024
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