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Objectives: Natural autoantibodies serve as an important anti‐tumorigenic component in the body. This study was thus designed to investigate whether circulating natural IgG autoantibodies against a cluster of differentiation 47 (CD47) could exert inhibitory effects on oral squamous cell carcinoma (OSCC). Subjects and methods: The expression levels of 13 tumor‐targeted genes in three OSCC cell lines were analyzed by qPCR, and CD47 expression in OSCC tissues was also verified with IHC staining. An in‐house ELISA was performed to analyze circulating anti‐CD47 IgG levels in control subjects, oral benign tumor, and OSCC patients, and to detect anti‐CD47 IgG‐abundant plasma. Three OSCC cell lines were treated with anti‐CD47 IgG‐abundant and ‐deficient plasma, respectively, followed by the analysis of cell proliferation, apoptosis, and invasion/metastasis. Results: The CD47 gene showed the highest expression among 13 genes detected in three OSCC cell lines; its expression was significantly higher in OSCC tissues than adjacent tissues. Plasma anti‐CD47 IgG levels showed the differences between control subjects, oral benign tumor, and OSCC patients. Anti‐CD47 IgG‐abundant plasma could evidently reduce cell viability via suppressing p‐AKT expression and inducing cell apoptosis and inhibit the invasion of all three OSCC cell lines. Conclusions: Natural autoantibodies against CD47 may be a potential agent for OSCC immunotherapy. [ABSTRACT FROM AUTHOR]

Objective: The purpose of our study was to investigate body mass index (BMI) as a prognostic factor and to examine the relationship between pretreatment BMI and oral squamous cell carcinoma (OSCC) outcomes in northern Chinese patients. Methods: This retrospective study enrolled 633 patients with OSCC who underwent surgery between 2004 and 2014. Results: Most baseline characteristics (gender, sites, smoking history, comorbidity, hypertension, T stage, clinical features, perineural invasion, flap reconstruction) were differentiated by BMI groups. Overall, the Kaplan–Meier curves indicated no significant relationship between BMI and disease‐free survival (DFS) or disease‐specific survival (DSS). Interestingly, obese patients exhibited higher risks of recurrence and death than normal‐weight patients (DFS: HR: 1.86, 95% CI: 1.16–2.96; DSS: HR: 2.04, 95% CI: 1.08–3.86). However, postoperative complications occurred more frequently in underweight patients than in normal‐weight patients. Conclusions: Obesity may contribute to a higher recurrence rate and a worse prognosis in OSCC patients than in normal‐weight patients in northern China. However, underweight patients have a higher risk of postoperative complications. [ABSTRACT FROM AUTHOR]