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941 results on '"Mao, Limin"'

3. Strengthening China’s National Essential Public Health Services Package for hypertension and diabetes care: protocol for an interrupted time series study with mixed-methods process evaluation and health economic evaluation

Author

Xiong, Shangzhi, Jiang, Wei, Zhang, Xinyi, Wang, Yongchen, Hu, Chi, Bao, Mingjia, Li, Fan, Yang, Jiajuan, Hou, Huinan, Peng, Nan, Wang, Qiujun, Jiang, Rui, Wang, Jin’ge, Liu, Tingzhuo, Ye, Pengpeng, Ma, Yanqiuzi, Li, Bingqin, Chen, Zhengming, Li, Qiang, Du, Xin, Lung, Thomas, Si, Lei, Mao, Limin, Peiris, David, and Tian, Maoyi

Published
2024
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11. Assessing HIV risk and the social and behavioural characteristics of gay and bisexual men who have recently migrated to Australia: an analysis of national, behavioural surveillance data 2019–2021

Author

Yu, Simin, Bavinton, Benjamin R., Chan, Curtis, Macgibbon, James, Mao, Limin, Vujcich, Daniel, Broady, Timothy R., and Holt, Martin

Subjects
Sentinel health events, Immigrants -- Health aspects, MSM (Men who have sex with men) -- Health aspects, Health risk assessment -- Evaluation, HIV infection -- Prevention, Health
Abstract

: Introduction:: Overseas‐born gay and bisexual men (GBM) are overrepresented in HIV diagnoses in Australia. We assessed social and sexual behaviours, and the use of HIV prevention and testing, by region of birth and length of residence in Australia. We sought to identify similarities and differences between recently arrived and non‐recently arrived GBM from non‐English‐speaking countries to improve targeting and engagement with HIV testing and prevention. Methods:: Data were collected in national repeated, behavioural surveillance surveys conducted across Australia during 2019–2021. Logistic regression was used to identify factors that differentiated between recently arrived ( Results: Among 24,707 participants in 2019–21, 2811 (11.4%) were from high‐income English‐speaking countries, 714 (2.9%) were recently arrived overseas‐born GBM and 3833 (15.5%) were non‐recently arrived migrants. Recently arrived GBM were most likely to be born in Asia (36.1%) and Europe (21.1%). Compared with non‐recently arrived GBM, recently arrived GBM from non‐English‐speaking countries were younger (aOR = 0.95, 95% CI = 0.94–0.96, p Conclusions: Recently arrived GBM from non‐English‐speaking countries reported similar levels of risk of HIV acquisition to longer‐term residents in Australia, but lower levels of PrEP awareness and use, and more reliance on HIV testing services which are free or low cost. It is necessary to enhance access to HIV testing and prevention among recently arrived GBM in Australia., INTRODUCTION In 2020, 29.8% of Australia's population was born overseas and over 7.6 million migrants were living in Australia [1]. In 2019, there were 2.43 million temporary migrants in Australia [...]

Published
2024
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24. Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models

Author

Wei, Ran, Mao, Limin, Xu, Ping, Zheng, Xinghai, Hackman, Robert M, Mackenzie, Gerardo G, and Wang, Yuefei

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Nutrition, Genetics, Women's Health, Cancer, Breast Cancer, Complementary and Integrative Health, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Animals, Apoptosis, Autophagy, Autophagy-Related Protein 5, Beclin-1, Breast Neoplasms, Caspase 3, Caspase 8, Caspase 9, Catechin, Cell Line, Tumor, Cell Proliferation, Cell Survival, Female, Glucose, Glucose Transporter Type 1, Hypoxia-Inducible Factor 1, alpha Subunit, Mice, Mice, Inbred BALB C, Microtubule-Associated Proteins, Polyphenols, Tea, Vascular Endothelial Growth Factor A, Xenograft Model Antitumor Assays, Food Sciences, Food sciences, Nutrition and dietetics
Abstract

Numerous studies propose that epigallocatechin-3-gallate (EGCG), an abundant polyphenol in green tea, has anti-cancer properties. However, its mechanism of action in breast cancer remains unclear. This study investigated the capacity of EGCG to suppress breast cancer cell growth in vitro and in vivo, characterizing the underlying mechanisms, focusing on the effect of EGCG on glucose metabolism. EGCG reduced breast cancer 4T1 cell growth in a concentration- (10-320 μM) and time- (12-48 h) dependent manner. EGCG induced breast cancer apoptotic cell death at 24 h, as evidenced by annexin V/PI, caspase 3, caspase 8 and caspase 9 activation. Furthermore, EGCG affected the expression of 16 apoptosis-related genes, and promoted mitochondrial depolarization. EGCG induced autophagy concentration-dependently in 4T1 cells by modulating the levels of the autophagy-related proteins Beclin1, ATG5 and LC3B. Moreover, EGCG affected glucose, lactate and ATP levels. Mechanistically, EGCG significantly inhibited the activities and mRNA levels of the glycolytic enzymes hexokinase (HK), phosphofructokinase (PFK), and lactic dehydrogenase (LDH), and to a lesser extent the activity of pyruvate kinase (PK). In addition, EGCG decreased the expression of hypoxia-inducible factor 1α (HIF1α) and glucose transporter 1 (GLUT1), critical players in regulating glycolysis. In vivo, EGCG reduced breast tumor weight in a dose-dependent manner, reduced glucose and lactic acid levels and reduced the expression of the vascular endothelial growth factor (VEGF). In conclusion, EGCG exerts an anti-tumor effect through the inhibition of key enzymes that participate in the glycolytic pathway and the suppression of glucose metabolism.

Published
2018

26. “We are studying abroad and need to protect ourselves first”: A mixed-methods study of attitudes towards hepatitis B among university students in Australia of Chinese and Vietnamese background

Author

Brener, Loren, primary, Horwitz, Robyn, additional, Cama, Elena, additional, Vu, Hoang Minh Khoi, additional, Jin, Defeng, additional, WU, Eric, additional, Rance, Jake, additional, Broady, Timothy, additional, Treloar, Carla, additional, Mao, Limin, additional, Okeke, Sylvester, additional, and Bryant, Joanne, additional

Published
2024
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45. A Hybrid Nested Partitions Method for Bi-objective Job Shop Scheduling Problem Considering Energy Consumption and Makespan

Author

Dai, Mei, Li, Xin, Mao, Limin, Angrisani, Leopoldo, Series editor, Arteaga, Marco, Series editor, Chakraborty, Samarjit, Series editor, Chen, Jiming, Series editor, Chen, Tan Kay, Series editor, Dillmann, Ruediger, Series editor, Duan, Haibin, Series editor, Ferrari, Gianluigi, Series editor, Ferre, Manuel, Series editor, Hirche, Sandra, Series editor, Jabbari, Faryar, Series editor, Kacprzyk, Janusz, Series editor, Khamis, Alaa, Series editor, Kroeger, Torsten, Series editor, Ming, Tan Cher, Series editor, Minker, Wolfgang, Series editor, Misra, Pradeep, Series editor, Möller, Sebastian, Series editor, Mukhopadhyay, Subhas Chandra, Series editor, Ning, Cun-Zheng, Series editor, Nishida, Toyoaki, Series editor, Panigrahi, Bijaya Ketan, Series editor, Pascucci, Federica, Series editor, Samad, Tariq, Series editor, Seng, Gan Woon, Series editor, Veiga, Germano, Series editor, Wu, Haitao, Series editor, Zhang, Junjie James, Series editor, Wang, Kesheng, editor, Wang, Yi, editor, Strandhagen, Jan Ola, editor, and Yu, Tao, editor

Published
2018
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49. Trends in illicit drug use and their association with HIV transmission risks from behavioural surveillance of Australian gay and bisexual men.

Author

Takeuchi, Jumpei, Chan, Curtis, MacGibbon, James, Broady, Timothy R., Lea, Toby, Mao, Limin, Bavinton, Benjamin R., and Holt, Martin

Subjects
HIV infection transmission, BISEXUAL men, DRUG abuse, GAY men, ANAL sex
Abstract

Introduction: Investigating drug trends among Australian gay and bisexual men (GBM) is crucial for understanding levels of use and the potential for harm, including HIV transmission risk. Method: Using repeated, national, cross‐sectional survey data collected between 2012 and 2021 (69,567 surveys), trends of recent (previous 6 months) and frequent (weekly) drug use were analysed, using logistic regression models. The last round of data from each jurisdiction (6709 surveys) was used to compare GBM who reported no use, infrequent (less than weekly) use and frequent (at least weekly) use of party drugs to investigate the association between party drug use and HIV transmission risk, using multinomial logistic regression models. Results: There was a significant upward trend in any recent drug use (from 58.4% in 2012 to 64.1% in 2021; p < 0.001). Frequent party drug use remained a minority practice over the period (consistently less than 3%). In cross‐sectional analysis, frequent party drug users were more likely to report behaviours with HIV transmission risks, such as condomless anal intercourse without biomedical prevention strategies (30.0% vs. 13.1%; adjusted relative risk ratio [aRRR], 2.08; 95% CI, 1.24–3.47), weekly group sex (16.3% vs. 0.6%; aRRR, 12.36; 95% CI, 5.75–26.56) and more than 20 recent sexual partners (42.5% vs. 5.0%; aRRR, 21.44; 95% CI, 5.82–78.89), compared with GBM who did not use party drugs. Discussion and Conclusion: Our findings suggest that the frequent use of party drugs remains a marker of HIV transmission risk among Australian GBM, despite the increased adoption of biomedical HIV prevention strategies over the past few years. [ABSTRACT FROM AUTHOR]

Published
2024
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