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A novel embedded GFRP grid framework-UHPC composite plate without steel rebar was proposed to solve the problems of conventional reinforced concrete plate, such as heavy weight, easily cracking and poor durability. The composite plate is expected to be superior in mechanical mechanism and durability benefiting from the combination of UHPC and GFRP, and only minimal construction process was needed. The flexural properties of the novel composite plate, varying in centroid height of GFRP grid and loading shear span ratio, were investigated via four-point loading tests. The failure mode, load-deflection curve, sectional strain and ductility of the composite plate were analyzed. Experimental results showed that the flexural failure process of the composite plate could be divided into three stages: elastic stage, working stage with cracks and descent stage. The flexural failure of the composite plate was characterized by the tensile fracture of GFRP grid. The flexural bearing capacity and stiffness of the composite plate can be significantly improved, since the GRFP grid was more completely tensioned as the centroid of the embedded GFRP grid framework fell. The maximum bearing capacity of composite plates could reach 317.9 kN when the distance between GFRP grid and the plate bottom was 25 mm and the shear span ratio was 1.5. Shear failure was only observed in the composite plate with the distance between GFRP grid and the plate bottom of 0 mm and the shear span ratio of 1.5. Finite element (FE) models were established considering both geometric and material nonlinearities to further analyze the flexural failure mechanism of the composite plate. The reliable connection between GFRP grid and UHPC without additional shear connector was proved, and the numerical results coincided well with the experimental ones. Finally, the calculation method introducing the stress distribution non-uniformity coefficient of the GFRP grid plate was proposed to predict the flexural capacity of the composite plate.

Interdisciplinary fields have become the driving force of modern science and a significant source of scientific innovation. However, there is still a paucity of analysis about the essential characteristics of disciplines’ cross-disciplinary impact.

Abstract From October 2017 to June 2022, we retrospectively report outcomes of R/R DLBCL patients with failure of CAR-T therapy, then receiving allo-HSCT. Among 10 patients, 5 were males and 5 females, with a median age of 43.5 (27–52) years. All patients were diagnosed refractory/relapsed diffuse large B cell lymphoma. The median time from CAR-T treatment to transplantation was 84.5 (31–370) days. The median follow-up was 21 (3–69) months. 5/10 patients attained CR and 1/10 patient attained PR during the follow up. The objective response rate (ORR) was 60%. The 1-year overall survival (OS) and progression-free survival (PFS) were 70% and 40%, respectively. At the time of the analysis, 6 patients were still living. During the follow up, four patients have died and the causes were disease relapses and progressions (2 patients), acute renal failure (1 patient), severe pulmonary infection (1 patient). Non-relapse was 20.0%.

USRP (ultrasonic surface rolling processing) was used to change the surface layer of 6061 aluminum alloy, so as to realize the change of the second phase microstructure of 6061 aluminum alloy by USRP under different static pressure conditions to improve corrosion resistant, which was characterized by using scanning electron microscopy, laser confocal microscopy, scanning Kelvin probe force microscopy, etc. Based on the principle of microzone galvanic corrosion and considering the impedance of solution and oxide, the correlation law between the size of the second phase and the development of local corrosion was obtained. The effect of the size of the second phase on the development of local corrosion was verified by in-situ observation using laser confocal microscope. The results show that the initial self-corrosion current density of aluminum alloy in 3.5%(mass fraction) NaCl solution is only 1/15 of that of the untreated sample, the corrosion rate is reduced by 93.04%, when the surface layer is rolled with 0.10 MPa static pressure. The Mg2Si phase has no significant morphology change during the rolling process, and it has no significant effect on the corrosion performance before and after USRP. The AlFeSi phases with long strip continuous distribution are refined into micro- and nano-scale dispersion distributions under the action of USRP. The fully refined AlFeSi phase weakens the galvanic corrosion effect due to the reduction of the local anode/cathode area ratio of the corrosion microcell, which promotes the metastable pitting nucleation rate of the aluminum alloy matrix, but also cause the rapid dissolution of the aluminum alloy itself. When self-dissolution occurs or Al2O3 oxide film is formed in the inner wall of metastable corrosion hole, the electrochemical corrosion effect of AlFeSi relative to aluminum alloy matrix is greatly weakened, so as to improve the corrosion resistance of 6061 aluminum alloy as a whole.

Abstract Hypopharyngeal squamous cell carcinoma (HPSCC) is one of the most aggressive cancers and is notorious for its extremely poor prognosis. However, very few molecular biological studies have been performed. As a novel method of epigenetic gene modulation, N6-methyladenosine (m6A) RNA modification occurs in HPSCC. The expression of the m6A demethylase AlkB homolog 5 (ALKBH5) is frequently downregulated in human HPSCC. Furthermore, we found that ALKBH5 impaired cell proliferation by regulating human Toll-like receptor 2 (TLR2) in an m6A-dependent manner in HPSCC cells. ALKBH5 decreased TLR2 m6A modification, which could be recognized by the m6A readers IGF2BP2 and YTHDF1. IGF2BP2 facilitates TLR2 mRNA stability, whereas YTHDF1 promotes TLR2 mRNA translation. The current work uncovered a critical function of ALKBH5 in TLR2 regulation and provides a novel role for m6A demethylation of mRNA in HPSCC. The inhibition of m6A modification of ALKBH5 in HPSCC deserves further clinical investigation.