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831 results on '"Mao, Chengde"'

7. Six-Letter DNA Nanotechnology: Incorporation of Z-PBase Pairs into Self-Assembling 3D Crystals

Author

Vecchioni, Simon, Ohayon, Yoel P., Hernandez, Carina, Hoshika, Shuichi, Mao, Chengde, Benner, Steven A., and Sha, Ruojie

Abstract

Artificially expanded genetic information systems (AEGIS) were developed to expand the diversity and functionality of biological systems. Recent experiments have shown that these expanded DNA molecular systems are robust platforms for information storage and retrieval as well as useful for basic biotechnologies. In tandem, nucleic acid nanotechnology has seen the use of information-based “semantomorphic” encoding to drive the self-assembly of a vast array of supramolecular devices. To establish the effectiveness of AEGIS toward nanotechnological applications, we investigated the ability of a six-letter alphabet composed of A:T, G:C and synthetic Z:P(Z, 6-amino-3-(1′-β-d-2′-deoxy ribofuranosyl)-5-nitro-(1H)-pyridin-2-one; P, 2-amino-8-(1′-β-d-2′-deoxyribofuranosyl)-imidazo-[1,2a]-1,3,5-triazin-(8H)-4-one) base pairs to engage in 3D self-assembly. We found that crystals could be programmably assembled from AEGIS oligomers. We conclude that unnatural base pairs can be used for the topological self-assembly of crystals. We anticipate the expansion of AEGIS-based nucleic acid nanotechnologies to enable the development of novel nanomaterials, high-fidelity signal cascades, and dynamic nanoscale devices.

Published
2024
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12. Light-regulated RNA interference induced by p-hydroxyphenacyl-modified siRNA in mammalian cells.

Author

Arora, Swati and Mao, Chengde

Subjects
*RNA interference, *SMALL interfering RNA, *GENETIC regulation, *CELL culture, *GENE expression, *ORGANIC synthesis
Abstract

siRNA is an important tool for modulating gene expression in current biomedical research. It would be highly desirable for siRNA to respond to an external stimulus. In this paper, we report a convenient, photolabile caging agent to regulate siRNA functions. 2-bromo-4'-hydroxyacetophenone (BHAP) can readily modify phosphorothioate backbones and inhibit siRNAs. Mild UV irradiation will cleave the modifying moiety to generate natural nucleic acid backbones, thus activating siRNA functions. Such modification is conveniently conducted in an aqueous solution with high efficiency and is cost-effective and scalable. This approach provides a convenient tool for the controlled regulation of gene expression by deploying minimal usage of complex organic synthesis for site-specific installation of the caging group to siRNA unlike previous reported works that required a series of intricate organic synthesis and cumbersome purification techniques to achieve similar aims. This study will open new doors for optochemical regulation of a variety of genes by pHP caging group in mammalian cell culture. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Heterobimetallic Base Pair Programming in Designer 3D DNA Crystals

Author

Lu, Brandon, primary, Ohayon, Yoel P., additional, Woloszyn, Karol, additional, Yang, Chu-fan, additional, Yoder, Jesse B., additional, Rothschild, Lynn J., additional, Wind, Shalom J., additional, Hendrickson, Wayne A., additional, Mao, Chengde, additional, Seeman, Nadrian C., additional, Canary, James W., additional, Sha, Ruojie, additional, and Vecchioni, Simon, additional

Published
2023
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17. Metal‐Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction

Author

Vecchioni, Simon, primary, Lu, Brandon, additional, Livernois, William, additional, Ohayon, Yoel P., additional, Yoder, Jesse B., additional, Yang, Chu‐Fan, additional, Woloszyn, Karol, additional, Bernfeld, William, additional, Anantram, M. P., additional, Canary, James W., additional, Hendrickson, Wayne A., additional, Rothschild, Lynn J., additional, Mao, Chengde, additional, Wind, Shalom J., additional, Seeman, Nadrian C., additional, and Sha, Ruojie, additional

Published
2023
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35. Augmented DNA Nanoarchitectures: A Structural Library of 3D Self‐Assembling Tensegrity Triangle Variants (Adv. Mater. 49/2022)

Author

Woloszyn, Karol, primary, Vecchioni, Simon, additional, Ohayon, Yoel P., additional, Lu, Brandon, additional, Ma, Yinglun, additional, Huang, Qiuyan, additional, Zhu, Eric, additional, Chernovolenko, Daniel, additional, Markus, Tiffany, additional, Jonoska, Nataša, additional, Mao, Chengde, additional, Seeman, Nadrian C., additional, and Sha, Ruojie, additional

Published
2022
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43. A Fresh Look at DNA Nanotechnology

Author

Deng, Zhaoxiang, Chen, Yi, Tian, Ye, Mao, Chengde, Rozenberg, G., editor, Bäck, Th., editor, Eiben, A. E., editor, Kok, J. N., editor, Spaink, H. P., editor, Chen, Junghuei, editor, Jonoska, Nataša, editor, and Rozenberg, Grzegorz, editor

Published
2006
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44. Structural DNA Nanotechnology: Molecular Construction and Computation

Author

Sha, Ruojie, Zhang, Xiaoping, Liao, Shiping, Constantinou, Pamela E., Ding, Baoquan, Wang, Tong, Garibotti, Alejandra V., Zhong, Hong, Israel, Lisa B., Wang, Xing, Wu, Gang, Chakraborty, Banani, Chen, Junghuei, Zhang, Yuwen, Yan, Hao, Shen, Zhiyong, Shen, Wanqiu, Sa-Ardyen, Phiset, Kopatsch, Jens, Zheng, Jiwen, Lukeman, Philip S., Sherman, William B., Mao, Chengde, Jonoska, Natasha, Seeman, Nadrian C., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Calude, Cristian S., editor, Dinneen, Michael J., editor, Păun, Gheorghe, editor, Pérez-Jímenez, Mario J., editor, and Rozenberg, Grzegorz, editor

Published
2005
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48. Nicks, Nodes, and New Motifs for DNA Nanotechnology

Author

Seeman, Nadrian C., Mao, Chengde, Liu, Furong, Sha, Ruojie, Yang, Xiaoping, Wenzler, Lisa, Li, Xiaojun, Shen, Zhiyong, Yan, Hao, Sa-Ardyen, Phiset, Zhang, Xiaoping, Shen, Wanqiu, Birac, Jeff, Lukeman, Philip, Pinto, Yariv, Qi, Jing, Liu, Bing, Qiu, Hangxia, Du, Shouming, Wang, Hui, Sun, Weiqiong, Wang, Yinli, Fu, Tsu-Ju, Zhang, Yuwen, Mueller, John E., Chen, Junghuei, Pavesi, Lorenzo, editor, and Buzaneva, Eugenia, editor

Published
2000
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