Search

A passive seismic experiment is carried out at the non-volcanic highly degassing site of Mefite d'Ansanto located at the northern tip of the Irpinia region (southern Italy), where the 1980 MS 6.9 destructive earthquake occurred. Between 2020 and 2021, background seismic noise was recorded by deploying a broadband seismic station and a seismic array composed of seven 1 Hz three-component sensors. Using two different array configurations, we were allowed to explore in detail the 1–20 Hz frequency band of the seismic noise wavefield as well as Rayleigh wave phase velocities in the 400–800 m/s range. Spectral analyses and array techniques were applied to one year of data showing that the frequency content of the signal is very stable in time. High frequency peaks are likely linked to the emission source, whereas at low frequencies seismic noise is clearly correlated to meteorological parameters. The results of this study show that small aperture seismic arrays probe the subsurface of tectonic CO2-rich emission areas and contribute to the understanding of the link between fluid circulation and seismogenesis in seismically active regions. [ABSTRACT FROM AUTHOR]

Mt. Vesuvius is a high-hazard active volcano surrounded by a densely populated area. Since human activities generate high levels of seismic noise, recognizing low-amplitude seismic events in the signals recorded by the local seismic monitoring network operating at Vesuvius is very difficult. Here, we describe an automatic procedure applied to continuous data with the aim of finding low-amplitude–low-frequency events hidden in the recorded signals. The methodology is based on the computation of two spectral parameters, central frequency Ω and shape factor ẟ, at selected sites, and the coherence of the seismic signal among different sites. The proposed procedure is applied to 28 months of recordings from 2019 to 2021, tuning the search parameters in order to find low-frequency signals similar to those occasionally observed in the past at the same volcano. The results allowed us to identify 80 seismic events that have the spectral features of low-frequency earthquakes or tremor. Among these, 12 events characterized by sufficiently high signal-to-noise ratio have been classified as deep low-frequency earthquakes, most of which are not reported in the catalog. The remaining events (more than 60) are characterized by similar spectral features but with an extremely low amplitude that prevents any reliable location of the source and definitive classification. The results of this work demonstrate that the low-frequency endogenous activity at Mt. Vesuvius volcano is more frequent that previously thought. [ABSTRACT FROM AUTHOR]

Following the M w 3.9 earthquake that occurred in the Ischia island (Naples, southern Italy) on 21 August 2017, the local monitoring seismic network was significantly improved in terms of both number of stations and instrumentation performance. Due to the huge amount of collected seismic ambient noise data, in this paper we present a first 3-D shear wave velocity model of the island retrieved from the inversion of horizontal-to-vertical spectral ratio curves by fixing the shear wave velocities (Vs) and modifying the thicknesses to get the corresponding 1-D Vs models. We are confident about the robustness of the attained models since the inversion process provided a good convergence towards the best-fitting solutions. Then, a first 3-D velocity model was obtained by contouring all the 1-D models obtained for the selected seismic stations to highlight possible lateral variations of the layer thicknesses and to reconstruct the morphology of the deeper interface characterized by a high-impedance contrast. A good correspondence between the 3-D Vs model and the geological features of the island was observed, especially in the northern sector where most of the stations are installed. In particular, the top of the high-impedance contrast interface appears deeper in the northern coastal areas and shallower in the central sector. This result agrees with the structural settings of the island likely due to the resurgence of Mount Epomeo. [ABSTRACT FROM AUTHOR]

Background: In the Italian Campania Region, 30.517 new cases of solid cancer have been diagnosed, in 2019. Of those, patients with metastatic disease are up to 20%. This class of patients is extremely diversified and copious, and the offer of radiotherapy may vary in different geographical areas within the same region. The aim of this observational multicenter retrospective and prospective trial is to evaluate the occurrence of metastatic metastatic cancer patients candidates for palliative radiotherapy in several areas of a great Italian region, the management of the disease through RT approaches, and its impact on cancer-related pain and overall HRQoL. Methods: This is a multicenter, retrospective and prospective observational investigation. The retrospective part of the study concerns all patients enrolled with a diagnosis of metastatic disease and treated in RT centers within the Campania Region between January 2019 and July 2020. The prospective phase is going to involve all the metastatic patients with an indication of palliative RT. Considering regional epidemiological data, we expect an enrollment of 12.500– 21.000 patients in 5 years. Conclusion: The MAMETIC Trial in an observational study designed for investigating on the use of radiotherapy in patients with advanced disease within a regional area, and for evaluating the local response to the patient's request. It can be a unique opportunity, not only to highlight possible geographic differences but also to regularly collect and share data to standardize the therapeutic offer within the regional area. ClinicalTrials.gov ID NCT04595032, retrospectively registered. [ABSTRACT FROM AUTHOR]

Abstract Introduction This is an observational study and the aim is to evaluate the effect of dietary supplements based on Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor®) in reducing skin toxicity due to external beam radiotherapy in patients affected by breast cancer. Materials and methods 71 patients were enrolled and they were divided in two different groups: a control group (CG) of 41 patients treated with prophylactic topical therapy based on hyaluronic acid and topical steroid therapy in case of occurrence of radiodermatitis, and a Ixor-Group (IG) of 30 patients treated also with an oral therapy based on Resveratrol, Lycopene, Vitamin C and Anthocyanin (Ixor®) at a dose of 2 tablets/day, starting from 10 days before the radiation treatment until 10 days after the end of treatment. Skin toxicity has been related to PTV, to breast volume that received a radiation dose equal or lower than 107%, included between 107% and 110%, or greater than 110% of the prescribed dose. Moreover it's been studied the relationship between skin toxicity and the chemotherapy schedule used before treatment. We calculated in both groups the percentage of patients who had a skin toxicity of grade 2 or 3 (according to RTOG scale). Absolute risk reduction (ARR), relative risk (RR) and odds ratio (OR) have been calculated for each relationship. Results Control Group (CG) patients with a PTV > 500 ml presented skin toxicity G2 + G3 in 30% of cases, versus 25% of Ixor-Group (IG) [OR 0.77]. In patients with a PTV < 500 ml G2 + G3 toxicity was 0% in the IG compared to 18% in CG (OR 0.23). When Dmax was less than or equal to 107% of the prescribed dose skin toxicity was G2 + G3 in 12.5% in CG, versus 0% in IG (OR 0.73), instead when Dmax was included between 107 and 110% of the prescribed dose, G2 + G3 skin toxicity was 35% in CG and 21% in IG (OR 0.50). In patients undergoing chemotherapy with anthracyclines and taxanes, G2 + G3 toxicity was 27% in CG, against 20% in IG (OR 0.68). Conclusions The protective effect of Resveratrol, Lycopene, Vitamin C and Anthocyanin (Ixor®) is more detected in patients with PTV < 500 ml, when Dmax reaches values lower or equal to 107%, but not exceeding 110% of the prescribed dose, and in patients undergoing adjuvant chemotherapy with anthracyclines and taxanes.

Background and purpose: The purpose of this study was to add, to the objective evaluation, an instrumental assessment of the skin damage induced by radiation therapy. Materials and methods: A group of 100 patients affected by breast cancer was recruited in the study over one year. Patients were divided into five groups of 20 patients. For each group it was prescribed a different topical treatment. The following products were used: Betaglucan, sodium hyaluronate (Neoviderm®), Vitis vinifera A. s-I-M.t- O.dij (Ixoderm®), Alga Atlantica plus Ethylbisiminomethylguaicolo and Manganese Cloruro (Radioskin1®) and Metal Esculetina plus Ginko Biloba and Aloe vera (Radioskin 2®); Natural triglycerides-fitosterols (Xderit®); Selectiose plus thermal water of Avene (Trixera+®). All hydrating creams were applied twice a day starting 15 days before and one month after treatment with radiations. Before and during treatment patients underwent weekly skin assessments and corneometry to evaluate the symptoms related to skin toxicity and state of hydration. Evaluation of acute cutaneous toxicity was defined according to the RTOG scale. Results: All patients completed radiotherapy; 72% of patients presented a G1 cutaneous toxicity, 18% developed a G2 cutaneous toxicity, 10% developed a G3 toxicity, no one presented G4 toxicity. The corneometry study confirmed the protective role of effective creams used in radiation therapy of breast cancer and showed its usefulness to identify radiation-induced dermatitis in a very early stage. Conclusions: The preventive use of topic products reduces the incidence of skin side effects in patients treated with radiotherapy for breast cancer. An instrumental evaluation of skin hydration can help the radiation oncologist to use strategies that prevent the onset of toxicity of high degree. All moisturizing creams used in this study were equally valid in the treatment of skin damage induced by radiotherapy. [ABSTRACT FROM AUTHOR]

The real-time monitoring of densely populated areas with high seismic and volcanic risk is of crucial importance for the safety of people and infrastructures. When an earthquake occurs, the Earth surface experiences both translational and rotational motions. The latter are usually not monitored, but their measurement and characterization are essential for a full description of the ground motion. Here we present preliminary observational data of a high-sensitivity rotational sensor based on a 2-km-long fiber-optic Sagnac gyroscope, presently under construction in the middle of the Campi Flegrei Volcanic Area (Pozzuoli, Italy). We have evaluated its performance by analyzing data continuously recorded during an acquisition campaign of five months. The experimental setup was composed of a digital nine-component seismic station equipped with both a rotational sensor and conventional seismic sensors (seismometers, accelerometers, and tiltmeters). During this experiment we detected seismic noise and ground rotations wavefield induced by small to medium local earthquakes ( M D <3). The prototype gyroscope shows a very promising sensitivity in the range of 5×10 -7 -8×10 -9 r a d / s / H z over the frequency bandwidth 5 mHz-50 Hz. Future upgrades and perspectives are discussed.

Oncologic emergencies are clinical situations that can lead to death in a short time (24-48 hours) if not quickly faced. In the clinical practice of the medical oncologist, such situations do not infrequently occur. The onset of oncologic emergencies may depend on the presence of cancer itself, the therapies carried out to counteract cancer, or the patient’s predisposition to develop such events. Mediastinal syndrome, spinal cord compression, endocranial hypertension, pancytopenia, metabolic syndromes, deep vein thrombosis, pulmonary thromboembolism, disseminated intravascular coagulation and the massive pericardial effusion are the main medical emergencies in oncology occurring in clinical practice. It is essential to recognize the aforementioned situations early in order to treat them promptly, thus avoiding serious consequences. This paper is aimed at presenting an overview on the topic, offering practical suggestions useful in daily clinical practice.