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7. Endothelial Extracellular Vesicles Enriched in microRNA-34a Predict New-Onset Diabetes in Coronavirus Disease 2019 (COVID-19) Patients: Novel Insights for Long COVID Metabolic Sequelae

Author

Mone, Pasquale, primary, Jankauskas, Stanislovas S., additional, Manzi, Maria Virginia, additional, Gambardella, Jessica, additional, Coppola, Antonietta, additional, Kansakar, Urna, additional, Izzo, Raffaele, additional, Fiorentino, Giuseppe, additional, Lombardi, Angela, additional, Varzideh, Fahimeh, additional, Sorriento, Daniela, additional, Trimarco, Bruno, additional, and Santulli, Gaetano, additional

Published
2024
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8. Achieving a Systolic Blood Pressure Below 130 mmHg Reduces the Incidence of Cardiovascular Events in Hypertensive Patients with Echocardiographic Left Ventricular Hypertrophy

Author

Lembo, Maria, primary, Trimarco, Valentina, additional, Izzo, Raffaele, additional, Manzi, Maria Virginia, additional, Rozza, Francesco, additional, Gallo, Paola, additional, Morisco, Carmine, additional, Bardi, Luca, additional, Esposito, Giovanni, additional, Forzano, Imma, additional, Santulli, Gaetano, additional, and Trimarco, Bruno, additional

Published
2023
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16. The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension

Author

Trimarco, Valentina, Manzi, Maria Virginia, Izzo, Raffaele, Mone, Pasquale, Lembo, Maria, Pacella, Daniela, Esposito, Giovanni, Falco, Angela, Morisco, Carmine, Gallo, Paola, Santulli, Gaetano, Trimarco, Bruno, Trimarco, Valentina, Manzi, Maria Virginia, Izzo, Raffaele, Mone, Pasquale, Lembo, Maria, Pacella, Daniela, Esposito, Giovanni, Falco, Angela, Morisco, Carmine, Gallo, Paola, Santulli, Gaetano, and Trimarco, Bruno

Subjects
concordance, adverse drug reactions, hypertension, adverse drug reaction, adherence, blood pressure, compliance, pharmacologic resistance, resistant hypertension, Cardiology and Cardiovascular Medicine
Abstract

BackgroundAdverse drug reactions (ADRs) remain among the leading causes of therapy-resistant hypertension (TRH) and uncontrolled blood pressure (BP). We have recently reported beneficial results in BP control in patients with TRH adopting an innovative approach, defined as therapeutic concordance, in which trained physicians and pharmacists reach a concordance with patients to make them more involved in the therapeutic decision-making process.MethodsThe main scope of this study was to investigate whether the therapeutic concordance approach could lead to a reduction in ADR occurrence in TRH patients. The study was performed in a large population of hypertensive subjects of the Campania Salute Network in Italy (ClinicalTrials.gov Identifier: NCT02211365).ResultsWe enrolled 4,943 patients who were firstly followed-up for 77.64 ± 34.44 months, allowing us to identify 564 subjects with TRH. Then, 282 of these patients agreed to participate in an investigation to test the impact of the therapeutic concordance approach on ADRs. At the end of this investigation, which had a follow-up of 91.91 ± 54.7 months, 213 patients (75.5%) remained uncontrolled while 69 patients (24.5%, p ConclusionOur findings indicate that the therapeutic concordance approach significantly reduces ADRs in TRH patients.

Published
2023

17. Left Ventricular Mechano-Energetic Efficiency Identifies an Early Impairment of Myocardial Blood Flow in Arterial Hypertension

Author

Lembo, Maria, primary, Acampa, Wanda, additional, Elena Rao, Maria Assunta, additional, Manzi, Maria Virginia, additional, Morisco, Carmine, additional, Esposito, Giovanni, additional, Assante, Roberta, additional, Zampella, Emilia, additional, Nappi, Carmela, additional, Gaudieri, Valeria, additional, Mannarino, Teresa, additional, Mancusi, Costantino, additional, de Simone, Giovanni, additional, Izzo, Raffaele, additional, Cuocolo, Alberto, additional, and Trimarco, Bruno, additional

Published
2023
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18. The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension

Author

Trimarco, Valentina, primary, Manzi, Maria Virginia, additional, Izzo, Raffaele, additional, Mone, Pasquale, additional, Lembo, Maria, additional, Pacella, Daniela, additional, Esposito, Giovanni, additional, Falco, Angela, additional, Morisco, Carmine, additional, Gallo, Paola, additional, Santulli, Gaetano, additional, and Trimarco, Bruno, additional

Published
2023
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20. Therapeutic concordance improves blood pressure control in patients with resistant hypertension

Author

Trimarco, Valentina, primary, Izzo, Raffaele, additional, Mone, Pasquale, additional, Lembo, Maria, additional, Manzi, Maria Virginia, additional, Pacella, Daniela, additional, Falco, Angela, additional, Gallo, Paola, additional, Esposito, Giovanni, additional, Morisco, Carmine, additional, Santulli, Gaetano, additional, and Trimarco, Bruno, additional

Published
2023
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22. 532 SEX-RELATED DIFFERENCES IN THROMBUS BURDEN IN ST-ELEVATION MYOCARDIAL INFARCTION PATIENTS UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION

Author

Manzi, Maria Virginia, primary, Buccheri, Sergio, additional, Jolly, Sanjit S, additional, Zijlstra, Felix, additional, Frobert, Ole, additional, Lagerqvist, Bo, additional, Mahmoud, Karim D, additional, Dzavik, Vladimir, additional, Barbato, Emanuele, additional, Sarno, Giovanna, additional, and James, Stefan, additional

Published
2022
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25. Association Between Lifestyle and Systemic Arterial Hypertension in Young Adults: A National, Survey-Based, Cross-Sectional Study

Author

Bruno, Rosa Maria, Pucci, Giacomo, Rosticci, Martina, Guarino, Laura, Guglielmo, Chiara, Agabiti Rosei, Claudia, Monticone, Silvia, Giavarini, Alessandra, Lonati, Chiara, Torlasco, Camilla, Fedecostante, Massimiliano, Manzi, Maria Virginia, Pezzutto, Francesca, Di Pilla, Marina, Artom, Nathan, Battistoni, Allegra, Pignatelli, Giulia, Sanga, Viola, and Pengo, Martino Francesco

Published
2016
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27. Sex-Related Differences in Thrombus Burden in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention

Author

Manzi, Maria Virginia, Buccheri, Sergio, Jolly, Sanjit S, Zijlstra, Felix, Frøbert, Ole, Lagerqvist, Bo, Mahmoud, Karim D, Džavík, Vladimír, Barbato, Emanuele, Sarno, Giovanna, James, Stefan, Manzi, Maria Virginia, Buccheri, Sergio, Jolly, Sanjit S, Zijlstra, Felix, Frøbert, Ole, Lagerqvist, Bo, Mahmoud, Karim D, Džavík, Vladimír, Barbato, Emanuele, Sarno, Giovanna, and James, Stefan

Abstract

BACKGROUND: Women have a worse prognosis after ST-segment elevation myocardial infarction (STEMI) than men. The prognostic role of thrombus burden (TB) in influencing the sex-related differences in clinical outcomes after STEMI has not been clearly investigated. OBJECTIVES: The aim of this study was to assess the sex-related differences in TB and its clinical implications in patients with STEMI. METHODS: Individual patient data from the 3 major randomized clinical trials of manual thrombus aspiration were analyzed, encompassing a total of 19,047 patients with STEMI, of whom 13,885 (76.1%) were men and 4,371 (23.9%) were women. The primary outcome of interest was 1-year cardiovascular (CV) death. The secondary outcomes of interest were recurrent myocardial infarction, heart failure, all-cause mortality, stroke, stent thrombosis (ST), and target vessel revascularization at 1 year. RESULTS: Patients with high TB (HTB) had worse 1-year outcomes compared with those presenting with low TB (adjusted HR for CV death: 1.52; 95% CI: 1.10-2.12; P = 0.01). In unadjusted analyses, female sex was associated with an increased risk for 1-year CV death regardless of TB. After adjustment, the risk for 1-year CV death was higher only in women with HTB (HR: 1.23; 95% CI: 1.18-1.28; P < 0.001), who also had an increased risk for all-cause death and ST than men. CONCLUSIONS: In patients with STEMI, angiographic evidence of HTB negatively affected prognosis. Among patients with HTB, women had an excess risk for ST, CV, and all-cause mortality than men. Further investigations are warranted to better understand the pathophysiological mechanisms leading to excess mortality in women with STEMI and HTB.

Published
2022
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28. SEX-RELATED DIFFERENCES IN THROMBUS BURDEN IN ST-ELEVATION MYOCARDIAL INFARCTION PATIENTS UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION

Author

Manzi, Maria Virginia, Buccheri, Sergio, Jolly, Sanjit S., Zijlstra, Felix, Fröbert, Ole, Lagerqvist, Bo, Mahmoud, Karim D., Dzavik, Vladimir, Barbato, Emanuele, Sarno, Giovanna, James, Stefan, Manzi, Maria Virginia, Buccheri, Sergio, Jolly, Sanjit S., Zijlstra, Felix, Fröbert, Ole, Lagerqvist, Bo, Mahmoud, Karim D., Dzavik, Vladimir, Barbato, Emanuele, Sarno, Giovanna, and James, Stefan

Abstract

Background: Women have a worse prognosis after ST-segment elevation myocardial infarction (STEMI) than men. The prognostic role of thrombus burden (TB) in influencing the sex-related differences in clinical outcomes after STEMI has not been clearly investigated. Objectives: The aim of this study was to assess the sex-related differences in TB and its clinical implication in patients with STEMI. Methods: We analyzed individual patient data from the 3 major randomized clinical trials of manual thrombus aspiration, encompassing a total of 19,047 patients with STEMI, of whom 13,885 (76.1%) were men and 4,371 (23.9%) were women. The primary outcome of interest was 1-year cardiovascular (CV) death. The secondary outcomes of interest were recurrent myocardial infarction, heart failure, all-cause mortality, stroke, stent thrombosis (ST), and target vessel revascularization at 1 year. Results: Patients with high TB (HTB) had worse 1-year outcomes compared with those presenting with low TB (adjusted HR for CV death; 1.52; 95% CI: 1.10-2.12; P=0.01). In unadjusted analyses, female sex was associated with an increased risk for 1-year CV death regardless of TB. After adjustment, this risk for 1-year CV death was higher only in women with HTB (HR 1.23, 95% CI: 1.18-1.28; P<0.001) who also had an increased risk for all-cause death and ST than men. Conclusion: In patients with STEMI, angiographic evidence of HTB negatively affected prognosis. Among patients with HTB, women had an excess risk for stent thrombosis, CV and all-cause mortality than men. Further investigations are warranted to better understand the pathophysiological mechanisms leading to excess mortality in women with STEMI and HTB.

Published
2022
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29. Accuracy of home blood pressure measurement: the ACCURAPRESS study–a proposal of Young Investigator Group of the Italian Hypertension Society (Società Italiana dell’Ipertensione Arteriosa)

Author

Mancusi, C, Bisogni, V, Maloberti, A, Manzi, M, Visco, V, Biolcati, M, Giani, V, Spannella, F, Monticone, S, Saladini, F, Rivasi, G, Turrin, G, Pucci, G, Pengo, M, Bertacchini, F, Ferri, C, Grassi, G, Muiesan, M, Mancusi, Costantino, Bisogni, Valeria, Maloberti, Alessandro, Manzi, Maria Virginia, Visco, Valeria, Biolcati, Marco, Giani, Valentina, Spannella, Francesco, Monticone, Silvia, Saladini, Francesca, Rivasi, Giulia, Turrin, Giada, Pucci, Giacomo, Pengo, Martino, Bertacchini, Fabio, Ferri, Claudio, Grassi, Guido, Muiesan, Maria Lorenza, Mancusi, C, Bisogni, V, Maloberti, A, Manzi, M, Visco, V, Biolcati, M, Giani, V, Spannella, F, Monticone, S, Saladini, F, Rivasi, G, Turrin, G, Pucci, G, Pengo, M, Bertacchini, F, Ferri, C, Grassi, G, Muiesan, M, Mancusi, Costantino, Bisogni, Valeria, Maloberti, Alessandro, Manzi, Maria Virginia, Visco, Valeria, Biolcati, Marco, Giani, Valentina, Spannella, Francesco, Monticone, Silvia, Saladini, Francesca, Rivasi, Giulia, Turrin, Giada, Pucci, Giacomo, Pengo, Martino, Bertacchini, Fabio, Ferri, Claudio, Grassi, Guido, and Muiesan, Maria Lorenza

Abstract

Purpose: Home blood pressure monitoring (HBPM) might be considered a valid alternative to ambulatory blood pressure monitoring (ABPM) for both the diagnosis and management of hypertension. Correct information on how to perform HBPM are crucial for its reliability. The aim of the present survey was to assess if hypertensive patients followed current recommendation on how to correctly perform HBPM measurements. Materials and methods: The survey included 30 different items on how to perform the HBPM. It was developed by the ‘Young Investigators’ group of the Italian Society of Arterial Hypertension (SIIA) and it was administered during the office visit between May 2019 and December 2021. Results: A total of 643 hypertensive patients participated in the study. Main results show that, despite the rate of informed patients was relatively high (71% of the whole population), unacceptable number of patients did not follow indications on how to perform a correct HBPM. Patients who were informed on how to measure home BP had a significantly higher rate of correct position during measurement (78 vs. 22%, p < 0.01), avoidance of talking and moving during measurement (68 vs. 32%, p < 0.0001), and correct number and time interval between two measurements (85 vs. 15%, p < 0.001). More accurate measurements of home BP were associated with less prevalence of carotid plaque. Conclusions: Correct performance for HBPM is low among patients treated in Italian hypertension centers. These findings shed light on the importance of correct HBPM measurements for the detection of accurate BP values for the proper management of hypertensive patients.

Published
2022

32. L-Arginine Enhances the Effects of Cardiac Rehabilitation on Physical Performance: New Insights for Managing Cardiovascular Patients During the COVID-19 Pandemic

Author

Mone, Pasquale, primary, Izzo, Raffaele, additional, Marazzi, Giuseppe, additional, Manzi, Maria Virginia, additional, Gallo, Paola, additional, Campolongo, Giuseppe, additional, Cacciotti, Luca, additional, Tartaglia, Domenico, additional, Caminiti, Giuseppe, additional, Varzideh, Fahimeh, additional, Santulli, Gaetano, additional, and Trimarco, Valentina, additional

Published
2022
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33. Insulin Resistance and Vitamin D Deficiency: A Link Beyond the Appearances

Author

Trimarco, Valentina, primary, Manzi, Maria Virginia, additional, Mancusi, Costantino, additional, Strisciuglio, Teresa, additional, Fucile, Ilaria, additional, Fiordelisi, Antonella, additional, Pilato, Emanuele, additional, Izzo, Raffaele, additional, Barbato, Emanuele, additional, Lembo, Maria, additional, and Morisco, Carmine, additional

Published
2022
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36. Accuracy of home blood pressure measurement: the ACCURAPRESS study – a proposal of Young Investigator Group of the Italian Hypertension Society (Società Italiana dell'Ipertensione Arteriosa).

Author

Mancusi, Costantino, Bisogni, Valeria, Maloberti, Alessandro, Manzi, Maria Virginia, Visco, Valeria, Biolcati, Marco, Giani, Valentina, Spannella, Francesco, Monticone, Silvia, Saladini, Francesca, Rivasi, Giulia, Turrin, Giada, Pucci, Giacomo, Pengo, Martino, Bertacchini, Fabio, Ferri, Claudio, Grassi, Guido, Muiesan, Maria Lorenza, Fucile, Ilaria, and Sorvillo, Gianmarco

Subjects
BLOOD pressure measurement, AMBULATORY blood pressure monitoring, BLOOD pressure, HYPERTENSION, ATHEROSCLEROTIC plaque
Abstract

Home blood pressure monitoring (HBPM) might be considered a valid alternative to ambulatory blood pressure monitoring (ABPM) for both the diagnosis and management of hypertension. Correct information on how to perform HBPM are crucial for its reliability. The aim of the present survey was to assess if hypertensive patients followed current recommendation on how to correctly perform HBPM measurements. The survey included 30 different items on how to perform the HBPM. It was developed by the 'Young Investigators' group of the Italian Society of Arterial Hypertension (SIIA) and it was administered during the office visit between May 2019 and December 2021. A total of 643 hypertensive patients participated in the study. Main results show that, despite the rate of informed patients was relatively high (71% of the whole population), unacceptable number of patients did not follow indications on how to perform a correct HBPM. Patients who were informed on how to measure home BP had a significantly higher rate of correct position during measurement (78 vs. 22%, p < 0.01), avoidance of talking and moving during measurement (68 vs. 32%, p < 0.0001), and correct number and time interval between two measurements (85 vs. 15%, p < 0.001). More accurate measurements of home BP were associated with less prevalence of carotid plaque. Correct performance for HBPM is low among patients treated in Italian hypertension centers. These findings shed light on the importance of correct HBPM measurements for the detection of accurate BP values for the proper management of hypertensive patients. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Differenze legate al sesso nel thrombus burden nei pazienti con infarto del miocardio con sopraslivellamento del segmento ST sottoposti a rivascolarizzazione coronarica percutanea

Author

Manzi, Maria Virginia

Abstract

Numerosi studi hanno dimostrato che il sesso femminile si associa a tassi più alti di mortalità ed eventi avversi dopo infarto miocardico acuto, rispetto al sesso maschile. Anche se l'esatto meccanismo alla base dell'eccesso di mortalità riscontrato nelle donne, non è ancora chiaro, studi recenti hanno dimostrato l'esistenza di differenze sesso specifiche nella formazione e stabilizzazione del trombo, con una maggiore attivazione piastrinica nelle donne rispetto agli uomini. Rimane ancora sconosciuto se differenze nel burden di trombosi possono spiegare, almeno in parte, le differenze sesso specifiche riportate nella prognosi dopo infarto del miocardio. In questo studio è stata analizzata una popolazione di 19,047 soggetti, sottoposti a P-PCI per STEMI e precedentemente arruolati in uno dei seguenti studi randomizzati: the Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS), the Thrombus Aspiration in ST-Elevation myocardial infarction in Scandinavia (TASTE) e the routine aspiration thrombectomy with PCI versus PCI alone in patients with STEMI undergoing primary PCI (TOTAL) trials. Il principale outcome di interesse era la morte cardiovascolare ad un anno. Lo studio ha evidenziato che i pazienti con un elevato thrombus burden avevano una prognosi peggiore rispetto ai pazienti con basso thrombus burden (HR per morte cardiovascolare 1.51, 95% CI 1.07-2.12, p=0.02). Inoltre, nell'analisi di Cox non aggiustata per i fattori di confondimento, il sesso femminile era associato con un aumentato rischio di morte cardiovascolare ad un anno, indipendentemente dal grado di thrombus burden. Dopo aggiustamento per i fattori di confondimento, il rischio di morte cardiovascolare ad un anno era alto solo nelle donne con un aumentato thrombus burden (HR 1.22, 95% CI 1.15 -1.30, P

Published
2021

43. Serum Uric Acid and Left Ventricular Mass in Essential Hypertension

Author

Visco, Valeria, primary, Pascale, Antonietta Valeria, additional, Virtuoso, Nicola, additional, Mongiello, Felice, additional, Cinque, Federico, additional, Gioia, Renato, additional, Finelli, Rosa, additional, Mazzeo, Pietro, additional, Manzi, Maria Virginia, additional, Morisco, Carmine, additional, Rozza, Francesco, additional, Izzo, Raffaele, additional, Cerasuolo, Federica, additional, Ciccarelli, Michele, additional, and Iaccarino, Guido, additional

Published
2020
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44. Assessment of carotid cross-sectional area in hypertensive patients: phenotyping and prognostic validation in The Campania Salute Network

Author

Mancusi, Costantino, primary, Canciello, Grazia, additional, Losi, Maria Angela, additional, Barbato, Emanuele, additional, Morisco, Carmine, additional, Manzi, Maria Virginia, additional, Arnone, Maria Immacolata, additional, Rozza, Francesco, additional, De Luca, Nicola, additional, and Izzo, Raffaele, additional

Published
2020
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45. A single blind, multicenter, randomized controlled trial to evaluate the effectiveness and cost of a novel nutraceutical (LopiGLIK®) lowering cardiovascular disease risk

Author

Manfrin, Andrea, Trimarco, Valentina, Manzi, Maria Virginia, Rozza, Francesco, Izzo, Raffaele, Manfrin, Andrea, Trimarco, Valentina, Manzi, Maria Virginia, Rozza, Francesco, and Izzo, Raffaele

Subjects
nutraceuticals, RS0200, hypercholesterolemia, Clinical Trial Report, RA0421, effectiveness, cardiovascular risk reduction, effectivene, RS
Abstract

Context: Cardiovascular disease (CVD) costs the economy €210 billion per year in Europe. There is an association between low-density lipoprotein cholesterol (LDL-C) and CVD risk.\ud Objective: To evaluate the cost and effectiveness of LopiGLIK® (LOPI) in lowering LDL-C and CVD risk.\ud Design: Single blind multicenter randomized controlled trial; patients were divided into two groups, subjected to centralized randomization.\ud Setting: Four Italian regions.\ud Participants: Thirty-one physicians enrolled 573 adult patients with mild hypercholesterolemia between January 2016 and January 2018.\ud Intervention: Patients were treated for 16 weeks either with LOPI (intervention) or Armolipid Plus® (AP; control).\ud Outcome measures: Primary outcome: percentage of patients who achieved LDL-C

Published
2018

47. Severity of Coronary Atherosclerosis and Risk of Diabetes Mellitus

Author

Colaiori, Iginio, primary, Izzo, Raffaele, additional, Barbato, Emanuele, additional, Franco, Danilo, additional, Di Gioia, Giuseppe, additional, Rapacciuolo, Antonio, additional, Bartunek, Jozef, additional, Mancusi, Costantino, additional, Losi, Maria Angela, additional, Strisciuglio, Teresa, additional, Manzi, Maria Virginia, additional, de Simone, Giovanni, additional, Trimarco, Bruno, additional, and Morisco, Carmine, additional

Published
2019
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48. A single blind, multicenter, randomized controlled trial to evaluate the effectiveness and cost of a novel nutraceutical (LopiGLIK®) lowering cardiovascular disease risk

Author

Manfrin,Andrea, Trimarco,Valentina, Manzi,Maria Virginia, Rozza,Francesco, Izzo,Raffaele, Manfrin,Andrea, Trimarco,Valentina, Manzi,Maria Virginia, Rozza,Francesco, and Izzo,Raffaele

Abstract

Andrea Manfrin,1 Valentina Trimarco,2,3 Maria Virginia Manzi,2,4 Francesco Rozza,2,4 Raffaele Izzo2,5 1Sussex Pharmacy, School of Life Sciences, University of Sussex, Falmer, Brighton, UK; 2Hypertension Research Centre, University of Naples Federico II, Naples, Italy; 3Department of Neurosciences, Federico II University, Naples, Italy; 4Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy; 5Department of Translational Medical Science Sciences, Federico II University, Naples, Italy Context: Cardiovascular disease (CVD) costs the economy €210 billion per year in Europe. There is an association between low-density lipoprotein cholesterol (LDL-C) and CVD risk.Objective: To evaluate the cost and effectiveness of LopiGLIK® (LOPI) in lowering LDL-C and CVD risk.Design: Single blind multicenter randomized controlled trial; patients were divided into two groups, subjected to centralized randomization.Setting: Four Italian regions.Participants: Thirty-one physicians enrolled 573 adult patients with mild hypercholesterolemia between January 2016 and January 2018.Intervention: Patients were treated for 16 weeks either with LOPI (intervention) or Armolipid Plus® (AP; control).Outcome measures: Primary outcome: percentage of patients who achieved LDL-C <130 mg/dL. Secondary outcomes: reduction of HbA1c, survival analysis and HR linked to 38.67 mg/dL reduction of LDL-C and 1% reduction of HbA1c. Costs were assessed per unit and cure.Results: Three hundred and seventy patients treated with LOPI and 203 treated with AP were randomized and completed the study. At baseline 8.9% (n=18) patients treated with AP and 9.5% (n=35) treated with LOPI had LDL-C levels <130 mg/dL (P=0.815). At the 16-week follow-up, 41.4% (n=84) of patients treated with AP and 67.6% (n=250) with LOPI achieved LDL-C levels <130 mg/dL (P<0.001). LOPI patients were three times more likely to achieve LDL-C levels &am

Published
2018

49. Assessment of carotid cross-sectional area in hypertensive patients: phenotyping and prognostic validation in The Campania Salute Network

Author

Mancusi, Costantino, Canciello, Grazia, Losi, Maria Angela, Barbato, Emanuele, Morisco, Carmine, Manzi, Maria Virginia, Arnone, Maria Immacolata, Rozza, Francesco, De Luca, Nicola, and Izzo, Raffaele

Abstract

Increased intima-media thickness (IMT) of common carotid artery (CA) is considered the hallmark of vascular hypertension-mediated target organ damage, even if vessel remodeling due to mechanical stress may also induce changes in diameter. We developed a method computing both diameter and IMT of CA, to assess correlates and prognostic impact of carotid cross-sectional area (CCSA) in a large registry of treated hypertensive patients. We selected 6300 hypertensive patients of the Campania Salute Network registry free of overt cardiovascular (CV) disease and with available CA ultrasound (54 ± 11 years; 57% male). CCSA was computed as:π×CAdiameter+2×meanIMT22−π×CAdiameter22.

Published
2021
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50. Evaluation of Unattended Automated Office, Conventional Office and Ambulatory Blood Pressure Measurements and Their Correlation with Target Organ Damage in an Outpatient Population of Hypertensives: Study Design and Methodological Aspects.

Author

Mancusi, Costantino, Saladini, Francesca, Pucci, Giacomo, Bertacchini, Fabio, Bisogni, Valeria, Bruno, Rosa Maria, Rivasi, Giulia, Maloberti, Alessandro, Manzi, Maria Virginia, Rosticci, Martina, Monticone, Silvia, de Feo, Martina, Del Pinto, Rita, Geraci, Giulio, Canciello, Grazia, Pengo, Martino, and Parati, Gianfranco

Subjects
ACADEMIC medical centers, AMBULATORY blood pressure monitoring, ATHEROSCLEROSIS, BLOOD pressure measurement, CARDIOVASCULAR diseases risk factors, ECHOCARDIOGRAPHY, HYPERTENSION, RISK assessment, ANKLE brachial index, LEFT ventricular hypertrophy, DISEASE complications
Abstract

Accurate measurement of blood pressure (BP) has a pivotal role in the management of patients with arterial hypertension. Recently, introduction of unattended office BP measurement has been proposed as a method allowing more accurate management of hypertensive patients and prediction of hypertension-mediated target organ damage (HMOD). This approach to BP measurement has been in particular proposed to avoid the white coat effect (WCE), which can be easily assessed once both attended and unattended BP measurements are obtained. In spite of its interest, the role of WCE in predicting HMOD remains largely unexplored. To fill this gap the Young Investigator Group of the Italian Hypertension Society (SIIA) conceived the study "Evaluation of unattended automated office, conventional office and ambulatory blood pressure measurements and their correlation with target organ damage in an outpatient population of hypertensives". This is a no-profit multicenter observational study aiming to correlate attended and unattended BP measurements for quantification of WCE and to correlate WCE with markers of HMOD, such us left ventricular hypertrophy, left atrial dilatation, and peripheral atherosclerosis. The Ethical committee of the Federico II University hospital has approved the study. [ABSTRACT FROM AUTHOR]

Published
2019
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