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382 results on '"Manyande, Anne"'

41. Neurogenesis manifestations of solid tumor and tracer imaging studies: a narrative review

Author

Huang, Yan, Xiang, Boqi, Manyande, Anne, Xiang, Hongbing, and Xiong, Jun

Subjects
Review Article
Abstract

With the emergence of the scientific research field of tumor microenvironment, the idea that tumor growth and propagation cannot be separated from the tumor microenvironment has become common. The autonomic nervous system is involved in the whole process of growth and development of the organism, and it is undeniable that the tumor microenvironment is equally regulated by both the autonomic nervous system and the immune system. Our research focused on the cancer-nerve crosstalk process and revealed the regulatory mechanisms between the autonomic nervous system and prostate, gastric, pancreatic ductal and breast cancers, mainly elucidating that (1) the release of neurotransmitters and their receptors by autonomic nerves may be important for solid tumor progression, and (2) in combination with the latest targeted small molecule imaging technology, we summarized the biological pathways related to neurotransmitters as small molecule tracers to track solid tumor progression. This research focused on combining targeted small molecules and imaging techniques to observe sympathetic and parasympathetic processes that promote or inhibit cancer development, providing new potential therapeutic targets for prostate, gastric, pancreatic ductal and breast cancers. It also provided cutting-edge research evidence for the development of biological small molecule drugs and targeted tracers in cancer therapy.

Published
2023

42. Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations

Author

Qin, Yuanyuan, Wu, Jinfeng, Chen, Tao, Li, Jia, Zhang, Guiling, Wu, Di, Zhou, Yiran, Zheng, Ning, Cai, Aoling, Ning, Qin, Manyande, Anne, Xu, Fuqiang, Wang, Jie, and Zhu, Wenzhen

Subjects
Prognosis -- Evaluation, Blood flow -- Health aspects, Health care industry
Abstract

BACKGROUND. The coronavirus disease 2019 (COVID-19) rapidly progressed to a global pandemic. Although some patients totally recover from COVID-19 pneumonia, the disease's long-term effects on the brain still need to be explored. METHODS. We recruited 51 patients with 2 subtypes of COVID-19 (19 mild and 32 severe) with no specific neurological manifestations at the acute stage and no obvious lesions on the conventional MRI 3 months after discharge. Changes in gray matter morphometry, cerebral blood flow (CBF), and white matter (WM) microstructure were investigated using MRI. The relationship between brain imaging measurements and inflammation markers was further analyzed. RESULTS. Compared with healthy controls, the decrease in cortical thickness/CBF and the changes in WM microstructure were more severe in patients with severe disease than in those with mild disease, especially in the frontal and limbic systems. Furthermore, changes in brain microstructure, CBF, and tract parameters were significantly correlated (P < 0.05) with the inflammatory markers C-reactive protein, procalcitonin, and interleukin 6. CONCLUSION. Indirect injury related to inflammatory storm may damage the brain, altering cerebral volume, CBF, and WM tracts. COVID-19-related hypoxemia and dysfunction of vascular endothelium may also contribute to neurological changes. The abnormalities in these brain areas need to be monitored during recovery, which could help clinicians understand the potential neurological sequelae of COVID-19. FUNDING. Natural Science Foundation of China., Introduction The highly infectious coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly progressed to a global pandemic and unleashed widespread concern around the world [...]

Published
2021
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50. The connectome from the cerebral cortex to skeletal muscle using viral transneuronal tracers: a review

Author

Huang, Yan, Zhang, Yunhua, He, Zhigang, Manyande, Anne, Wu, Duozhi, Feng, Maohui, and Xiang, Hongbing

Subjects
health
Abstract

Connectomics has developed from an initial observation under an electron microscope to the present wellknown medical imaging research approach. The emergence of the most popular transneuronal tracers has further advanced connectomics research. Researchers use the virus trans-nerve tracing method to trace the whole brain, mark the brain nerve circuit and nerve connection structure, and construct a complete nerve conduction pathway. This review assesses current methods of studying cortical to muscle connections using viral neuronal tracers and demonstrates their application in disease diagnosis and prognosis.

Published
2022

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