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4. Hemophagocytic Lymphohistiocytosis and Miliary Tuberculosis in an Apparently Immunocompetent Patient: A Case Report

Author

Filippo Ducci, Francesca Mariotti, Jessica Mencarini, Claudio Fabbri, Alessandra Francesca Manunta, Daniela Messeri, Paola Parronchi, Pierluigi Blanc, and Alessandro Bartoloni

Subjects
hemophagocytic lymphoistiocytosis, tuberculosis, paradoxical reaction, Other systems of medicine, RZ201-999
Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a serious haematologic condition that can be related to various diseases, including tuberculosis (TB). The patient is a previously healthy 26-year-old man, originally from western Africa, admitted to hospital for fever and weight loss. Given the results of a computed tomography (CT) scan, ocular examination and microbiologic tests, miliary TB with pulmonary, lymph nodal and ocular involvement was diagnosed. Following the introduction of antitubercular treatment (ATT), an increase in inflammation indexes and severe pancytopenia were observed; at this point, the patient presented with six of the eight diagnostic criteria for HLH, and a diagnosis of HLH secondary to TB was raised. Therefore, HLH treatment with a high dose of dexamethasone was started, with a good clinical response. We performed a literature review of TB-related HLH, which shows a high mortality rate. ATT is necessary to ensure patient survival to remove the antigenic driver. Our patient developed HLH after the initiation of ATT as a paradoxical reaction, which may be linked to the release of antigens due to the bactericidal effect of ATT.

Published
2024
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5. Sarcopenic obesity and pre-sarcopenia contribute to frailty in community-dwelling Italian older people: data from the FRASNET study

Author

Sarah Damanti, Lorena Citterio, Laura Zagato, Elena Brioni, Cristiano Magnaghi, Marco Simonini, Rebecca De Lorenzo, Mariapia Ruggiero, Simona Santoro, Eleonora Senini, Marco Messina, Giordano Vitali, Paolo Manunta, Angelo A. Manfredi, Chiara Lanzani, and Patrizia Rovere Querini

Subjects
Body composition, Frailty index, Sarcopenia, Sarcopenic obesity, Geriatrics, RC952-954.6
Abstract

Abstract Background The ageing process is characterized by a change of body composition with an increase of fat mass and a reduction of muscle mass. Above a certain threshold these alterations configure a condition named sarcopenic obesity (SO). SO is associated with physical frailty in Asian and Brazilian populations. SO impacts on physical frailty in other ethnic groups but its influence on general frailty which is multidimensional and includes cognitive, social and physical factors, remain insufficiently explored in the Italian population. Methods Frailty was measured in community dwelling Italian older adults enrolled in the FRASNET study with the frailty index (FI). The FI quantifies frailty as the ratio of the number of present health deficits to the total number of health deficits considered. Regression analyses were performed to assess the association between body composition categories and frailty. Classification and regression tree models were run to evaluate the frailty predictors. Results One Thousand One Hundred Fourteen participants of the FRASNET study were included in the present analysis. The sample was composed for the 60.5% by females and its median age was 72 years. The median FI score was 0.11 (IQR 0.07–0.20); 234 individuals (21%) were frail (FI ≥ 0.25). SO (B 0.074, 95% C.I. 0.05–0.1, p

Published
2024
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6. DNA polymorphisms in inflammatory and endocrine signals linked to frailty are also associated with obesity: data from the FRASNET cohort

Author

Sarah Damanti, Lorena Citterio, Laura Zagato, Elena Brioni, Cristiano Magnaghi, Marco Simonini, Rebecca De Lorenzo, Mariapia Ruggiero, Simona Santoro, Eleonora Senini, Marco Messina, Giordano Vitali, Paolo Manunta, Angelo Andrea Manfredi, Chiara Lanzani, and Patrizia Rovere Querini

Subjects
obesity, frailty, SNP, predisposition, older people, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

BackgroundObesity and frailty are prevalent geriatric conditions that share some pathophysiological mechanisms and are associated with adverse clinical outcomes. The relationship between frailty, obesity, and polymorphism remains inadequately explored. Single nucleotide polymorphisms (SNPs) offer insights into genetic predispositions that may influence the development of both frailty and obesity.MethodsWe aimed at investigating whether SNPs associated with frailty also play a role in obesity. Data were collected from the FRASNET cross-sectional study, which included community-dwelling older individuals residing in Milan and nearby areas. Participants were recruited through random sampling. They underwent multidimensional geriatric assessments, which included the collection of blood samples for SNP analysis. Frailty was assessed using the frailty index, and body composition was evaluated using bioelectrical impedance analysis and anthropometric measures.ResultsSNPs related to frailty and linked to the renin–angiotensin system (CYP11B2 rs1799998, AGT rs5051, and AGTR1 rs2131127), apoptosis pathways (CASP8 rs6747918), growth hormone signaling (GHR rs6180), inflammation (TLR4 rs5030717, CD33 rs3865444, and FN1 rs7567647), adducin (ADD3 rs3731566), and the 9p21–23 region (rs518054) were found to be associated with various measures of obesity in community-dwelling older adults.ConclusionsFrailty-related SNPs contribute to obesity in community-dwelling older adults. We identified a novel association between adducin SNPs and visceral fat, which has not been previously reported. Detecting genetic predispositions to obesity and frailty early could aid in identifying individuals at risk, facilitating the adoption of preventive interventions. This represents an initial step toward promoting early intervention strategies.

Published
2024
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12. Exploring Attitudes Toward “Sugar Relationships” Across 87 Countries: A Global Perspective on Exchanges of Resources for Sex and Companionship

Author

Meskó, Norbert, Kowal, Marta, Láng, András, Kocsor, Ferenc, Bandi, Szabolcs A., Putz, Adam, Sorokowski, Piotr, Frederick, David A., García, Felipe E., Aguilar, Leonardo A., Studzinska, Anna, Tan, Chee-Seng, Gjoneska, Biljana, Milfont, Taciano L., Topcu Bulut, Merve, Grigoryev, Dmitry, Aavik, Toivo, Boussena, Mahmoud, Mattiassi, Alan D. A., Afhami, Reza, Amin, Rizwana, Baiocco, Roberto, Brahim, Hamdaoui, Can, Ali R., Carneiro, Joao, Çetinkaya, Hakan, Chubinidze, Dimitri, Deschrijver, Eliane, Don, Yahya, Dubrov, Dmitrii, Duyar, Izzet, Jovic, Marija, Kamburidis, Julia A., Khan, Farah, Khun-Inkeeree, Hareesol, Koso-Drljevic, Maida, Lacko, David, Massar, Karlijn, Morelli, Mara, Natividade, Jean C., Nyhus, Ellen K., Park, Ju Hee, Pazhoohi, Farid, Pirtskhalava, Ekaterine, Ponnet, Koen, Prokop, Pavol, Šakan, Dušana, Tulyakul, Singha, Wang, Austin H., Aquino, Sibele D., Atamtürk, Derya D., Burduli, Nana, Chirumbolo, Antonio, Dural, Seda, Etchezahar, Edgardo, Ghahraman Moharrampour, Nasim, Aczel, Balazs, Kozma, Luca, Lins, Samuel, Manunta, Efisio, Marot, Tiago, Mebarak, Moises, Miroshnik, Kirill G., Misetic, Katarina, Papadatou-Pastou, Marietta, Bakos, Bence, Sahli, Fatima Zahra, Singh, Sangeeta, Solak, Çağlar, Volkodav, Tatiana, Wlodarczyk, Anna, Akello, Grace, Argyrides, Marios, Çoker, Ogeday, Galasinska, Katarzyna, Gómez Yepes, Talía, Kobylarek, Aleksander, Landa-Blanco, Miguel, Mayorga, Marlon, Özener, Barış, Pacquing, Ma. Criselda T., Reyes, Marc Eric S., Şahin, Ayşegül, Tamayo-Agudelo, William, Topanova, Gulmira, Toplu-Demirtaş, Ezgi, Türkan, Belgüzar N., Zumárraga-Espinosa, Marcos, Grassini, Simone, Antfolk, Jan, Cornec, Clément, Pisanski, Katarzyna, Stöckli, Sabrina, Eder, Stephanie Josephine, and Han, Hyemin

Published
2024
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13. Validation of the Short Version (TLS-15) of the Triangular Love Scale (TLS-45) across 37 Languages

Author

Kowal, Marta, Sorokowski, Piotr, Dinić, Bojana M., Pisanski, Katarzyna, Gjoneska, Biljana, Frederick, David A., Pfuhl, Gerit, Milfont, Taciano L., Bode, Adam, Aguilar, Leonardo, García, Felipe E., Roberts, S. Craig, Abad-Villaverde, Beatriz, Kavčič, Tina, Miroshnik, Kirill G., Ndukaihe, Izuchukwu L. G., Šafárová, Katarína, Valentova, Jaroslava V., Aavik, Toivo, Blackburn, Angélique M., Çetinkaya, Hakan, Duyar, Izzet, Guemaz, Farida, Ishii, Tatsunori, Kačmár, Pavol, Natividade, Jean C., Nussinson, Ravit, Omar-Fauzee, Mohd Sofian B., Pacquing, Ma. Criselda T., Ponnet, Koen, Wang, Austin H., Yoo, Gyesook, Amin, Rizwana, Pirtskhalava, Ekaterine, Afhami, Reza, Arvanitis, Alexios, Duyar, Derya Atamturk, Besson, Théo, Boussena, Mahmoud, Can, Seda, Can, Ali R., Carneiro, João, Castro, Rita, Chubinidze, Dimitri, Čunichina, Ksenija, Don, Yahya, Dural, Seda, Etchezahar, Edgardo, Fekih-Romdhane, Feten, Frackowiak, Tomasz, Moharrampour, Nasim Ghahraman, Yepes, Talía Gómez, Grassini, Simone, Jovic, Marija, Kertechian, Kevin S., Khan, Farah, Kobylarek, Aleksander, Križanić, Valerija, Lins, Samuel, Mandzyk, Tetyana, Manunta, Efisio, Martinac Dorčić, Tamara, Muthu, Kavitha N., Najmussaqib, Arooj, Otterbring, Tobias, Park, Ju Hee, Pavela Banai, Irena, Perun, Mariia, Reyes, Marc Eric S., Röer, Jan P., Şahin, Ayşegül, Sahli, Fatima Zahra, Šakan, Dušana, Singh, Sangeeta, Smojver-Azic, Sanja, Söylemez, Sinem, Spasovski, Ognen, Studzinska, Anna, Toplu-Demirtas, Ezgi, Urbanek, Arkadiusz, Volkodav, Tatiana, Wlodarczyk, Anna, Yaakob, Mohd Faiz Mohd Y., Yusof, Mat Rahimi, Zumárraga-Espinosa, Marcos, Zupančič, Maja, and Sternberg, Robert J.

Published
2024
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15. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Andrea Lombardi, Simone Villa, Marta Colaneri, Giovanni Scaglione, Francesca Bai, Benedetta Varisco, Valeria Bono, Antonio Vena, Chiara Dentone, Chiara Russo, Mauro Tettamanti, Giulia Renisi, Giulia Viero, Cecilia Azzarà, Marco Mantero, Flora Peyvandi, Matteo Bassetti, Giulia Marchetti, Antonio Muscatello, Alessandro Nobili, Andrea Gori, Alessandra Bandera, Silvano Bosari, Luigia Scudeller, Giuliana Fusetti, Laura Rusconi, Silvia Dell’Orto, Daniele Prati, Luca Valenti, Silvia Giovannelli, Maria Manunta, Giuseppe Lamorte, Francesca Ferarri, Andrea Gori., Davide Mangioni, Laura Alagna, Giorgio Bozzi, Andrea Lombardi., Riccardo Ungaro, Giuseppe Ancona, Marco Mussa, Bianca Veronica Mariani, Matteo Bolis, Nathalie Iannotti, Serena Ludovisi, Agnese Comelli, Simona Biscarini, Valeria Castelli, Emanuele Palomba, Marco Fava, Carlo Alberto Peri, Paola Saltini, Teresa Itri, Valentina Ferroni, Valeria Pastore, Roberta Massafra, Arianna Liparoti, Toussaint Muheberimana, Alessandro Giommi, Rosaria Bianco, Grazia Eliana Chitani, Chiara Bobbio, Irene De Matteis, Angelo Bianchi Bonomi, Roberta Gualtierotti, Barbara Ferrari, Raffaella Rossio, Nadia Boasi, Erica Pagliaro, Costanza Massimo, Michele De Caro, Andrea Giachi, Nicola Montano, Barbara Vigone, Chiara Bellocchi, Angelica Carandina, Elisa Fiorelli, Valerie Melli, Eleonora Tobaldini, Francesco Blasi, Stefano Aliberti, Maura Spotti, Leonardo Terranova, Sofia Misuraca, Alice D’Adda, Silvia Della Fiore, Marta Di Pasquale, Marco Mantero., Martina Contarini, Margherita Ori, Letizia Morlacchi, Valeria Rossetti, Andrea Gramegna, Maria Pappalettera, Mirta Cavallini, Agata Buscemi, Marco Vicenzi, Irena Rota, Giorgio Costantino, Monica Solbiati, Ludovico Furlan, Marta Mancarella, Giulia Colombo, Giorgio Colombo, Alice Fanin, Mariele Passarella, Valter Monzani, Ciro Canetta, Angelo Rovellini, Laura Barbetta, Filippo Billi, Christian Folli, Silvia Accordino, Diletta Maira, Cinzia Maria Hu, Irene Motta, Natalia Scaramellini, Anna Ludovica Fracanzani, Rosa Lombardi, Annalisa Cespiati, Matteo Cesari, Tiziano Lucchi, Marco Proietti, Laura Calcaterra, Clara Mandelli, Carlotta Coppola, Arturo Cerizza, Antonio Maria Pesenti, Giacomo Grasselli, Alessandro Galazzi, Alessandro Nobili., Igor Monti, Alessia Antonella Galbussera, Ernesto Crisafulli, Domenico Girelli, Alessio Maroccia, Daniele Gabbiani, Fabiana Busti, Alice Vianello, Marta Biondan, Filippo Sartori, Paola Faverio, Alberto Pesci, Stefano Zucchetti, Paolo Bonfanti, Marianna Rossi, Ilaria Beretta, Anna Spolti, Sergio Harari, Davide Elia, Roberto Cassandro, Antonella Caminati, Francesco Cipollone, Maria Teresa Guagnano, Damiano D’Ardes, Ilaria Rossi, Francesca Vezzani, Antonio Spanevello, Francesca Cherubino, Dina Visca, Marco Contoli, Alberto Papi, Luca Morandi, Nicholas Battistini, Guido Luigi Moreo, Pasqualina Iannuzzi, Daniele Fumagalla, and Sara Leone

Subjects
Vaccination, Breakthrough infection, SARS-COV-2, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270
Abstract

Background: Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, and retrospective study aimed to investigate the clinical characteristics and outcomes of vaccinated vs. non-vaccinated patients, both hospitalised with SARS-CoV-2 infection in 3 major hospitals in Northern Italy. Methods: Data collection was retrospective, and paper and electronic medical records of adult patients with a diagnosed SARS-CoV-2 infection were pseudo-anonymised and analysed. Vaccinated and non-vaccinated individuals were manually paired, using a predetermined matching criterion (similar age, gender, and date of hospitalisation). Demographic, clinical, treatment, and outcome data were compared between groups differing by vaccination status using Pearson’s Chi-square and Mann-Whitney tests. Moreover, multiple logistic regression analyses were performed to assess the impact of vaccination status on ICU admission or intra-hospital mortality. Results: Data from 360 patients were collected. Vaccinated patients presented with a higher prevalence of relevant comorbidities, like kidney replacement therapy or haematological malignancy, despite a milder clinical presentation at the first evaluation. Non-vaccinated patients required intensive care more often than their vaccinated counterparts (8.8% vs. 1.7%, p = 0.002). Contrariwise, no difference in intra-hospital mortality was observed between the two groups (19% vs. 20%, p = 0.853). These results were confirmed by multivariable logistic regressions, which showed that vaccination was significantly associated with decreased risk of ICU admission (aOR=0.172, 95%CI: 0.039–0.542, p = 0.007), but not of intra-hospital mortality (aOR=0.996, 95%CI: 0.582–1.703, p = 0.987). Conclusions: This study provides real-world data on vaccinated patients hospitalised with COVID-19 in Northern Italy. Our results suggest that COVID-19 vaccination has a protective role in individuals with higher risk profiles, especially regarding the need for ICU admission. These findings contribute to our understanding of SARS-CoV-2 infection outcomes among vaccinated individuals and emphasise the importance of vaccination in preventing severe disease, particularly in those countries with lower first-booster uptake rates.

Published
2024
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16. Torre Viva | Torre Afona

Author

Houssam Mahi and Lorenzo Manunta

Subjects
Monumento memoriale, Lampedusa, Mito, Architecture, NA1-9428
Abstract

«Gli istanti si susseguono gli uni agli altri: nulla conferisce loro l'illusione di un contenuto o la parvenza di un significato; si svolgono; il loro corso non è il nostro; prigionieri di una percezione inebetita, li guardiamo passare; il vuoto del cuore dinanzi al vuoto del tempo: due specchi, uno di fronte all’altro, che riflettono la loro assenza, una stessa immagine di nullità... Come sotto l’effetto di un’idiozia sognante, ogni cosa si livella: niente più cime, niente più abissi... Dove scoprire la poesia delle menzogne, il pungolo di un enigma?» (Cioran 1996, p. 26). In questa “convalescenza incurabile” guidata dalla noia, ci si chiede in che modo, in una realtà in cui «i dati e le informazioni non possiedono alcuna forza simbolica, per cui non consentono il riconoscimento» (Chul Han 2021, p. 12), il Monumento possa imprimere nella memoria un determinato evento.

Published
2024
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17. First evidence of a geodetic anomaly in the Campi Flegrei caldera (Italy) ground deformation pattern revealed by DInSAR and GNSS measurements during the 2021–2023 escalating unrest phase

Author

Flora Giudicepietro, Francesco Casu, Manuela Bonano, Claudio De Luca, Prospero De Martino, Federico Di Traglia, Mauro Antonio Di Vito, Giovanni Macedonio, Michele Manunta, Fernando Monterroso, Pasquale Striano, and Riccardo Lanari

Subjects
DInSAR, GNSS, Campi Flegrei, Analytical Modeling, Anomaly detection, Physical geography, GB3-5030, Environmental sciences, GE1-350
Abstract

Campi Flegrei caldera is an Italian high-risk volcano experiencing a progressively more intense long-term uplift, accompanied by increasing seismicity and geochemical emissions over the last two decades. Ground deformation shows an axisymmetric bell-shaped pattern, with a maximum uplift of about 120 cm, from 2005, in the caldera central area. We analyzed Sentinel-1 and COSMO-SkyMed Multi-Temporal DInSAR measurements and GNSS data to reveal and investigate a geodetic anomaly that has clearly manifested since 2021, locally deviating from the typical bell-shaped deformation pattern. This anomaly is located east of Pozzuoli town, in the Mt. Olibano–Accademia area, covers an area of about 1.3 km2 and shows, in comparison to surrounding areas, a maximum uplift deficit of about 9 cm between 2021 and 2023. To investigate the anomaly causes, we analyzed the caldera seismicity and inverted the DInSAR data to determine the primary source of the ground deformation pattern, which is consistent with a penny-shaped source located approximately 3800 m beneath the Pozzuoli town, with a radius of about 1200 m. We also found that the time evolution of the uplift deficit in the geodetic anomaly area correlates well with the earthquake occurrence, with the greater magnitude events clustering in this area. These considerations suggest the geodetic anomaly is a local response to the tensile stress regime produced by the inflating primary deformation source. This phenomenon can be influenced by the Mt. Olibano–Accademia lava domes lithological heterogeneities that may induce a localized reaction to ground deformation during the inflationary phase. Our interpretation aligns with the concentration of earthquakes and hydrothermal fluid emissions in this area, indicating the presence of faults, fractures, and fluid circulation. Accordingly, the geodetic anomaly area represents a zone of crustal weakness that requires careful monitoring and study.

Published
2024
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18. Correction to: Validation of the Short Version (TLS-15) of the Triangular Love Scale (TLS-45) Across 37 Languages

Author

Kowal, Marta, Sorokowski, Piotr, Dinić, Bojana M., Pisanski, Katarzyna, Gjoneska, Biljana, Frederick, David A., Pfuhl, Gerit, Milfont, Taciano L., Bode, Adam, Aguilar, Leonardo, García, Felipe E., Roberts, S. Craig, Abad-Villaverde, Beatriz, Kavčič, Tina, Miroshnik, Kirill G., Ndukaihe, Izuchukwu L. G., Šafárová, Katarína, Valentova, Jaroslava V., Aavik, Toivo, Blackburn, Angélique M., Çetinkaya, Hakan, Duyar, Izzet, Guemaz, Farida, Ishii, Tatsunori, Kačmár, Pavol, Natividade, Jean C., Nussinson, Ravit, Omar-Fauzee, Mohd Sofian B., Pacquing, Ma. Criselda T., Ponnet, Koen, Wang, Austin H., Yoo, Gyesook, Amin, Rizwana, Pirtskhalava, Ekaterine, Afhami, Reza, Arvanitis, Alexios, Duyar, Derya Atamturk, Besson, Théo, Boussena, Mahmoud, Can, Seda, Can, Ali R., Carneiro, João, Castro, Rita, Chubinidze, Dimitri, Čunichina, Ksenija, Don, Yahya, Dural, Seda, Etchezahar, Edgardo, Fekih-Romdhane, Feten, Frackowiak, Tomasz, Moharrampour, Nasim Ghahraman, Yepes, Talía Gómez, Grassini, Simone, Jovic, Marija, Kertechian, Kevin S., Khan, Farah, Kobylarek, Aleksander, Križanić, Valerija, Lins, Samuel, Mandzyk, Tetyana, Manunta, Efisio, Martinac Dorčić, Tamara, Muthu, Kavitha N., Najmussaqib, Arooj, Otterbring, Tobias, Park, Ju Hee, Pavela Banai, Irena, Perun, Mariia, Reyes, Marc Eric S., Röer, Jan P., Şahin, Ayşegül, Sahli, Fatima Zahra, Šakan, Dušana, Singh, Sangeeta, Smojver-Azic, Sanja, Söylemez, Sinem, Spasovski, Ognen, Studzinska, Anna, Toplu-Demirtas, Ezgi, Urbanek, Arkadiusz, Volkodav, Tatiana, Wlodarczyk, Anna, Yaakob, Mohd Faiz Mohd Y., Yusof, Mat Rahimi, Zumárraga-Espinosa, Marcos, Zupančič, Maja, and Sternberg, Robert J.

Published
2024
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21. The reimbursement system can influence the treatment choice and favor joint replacement versus other less invasive solutions in patients affected by osteoarthritis

Author

De Marziani, Luca, Boffa, Angelo, Di Martino, Alessandro, Andriolo, Luca, Reale, Davide, Bernasconi, Alessio, Corbo, Valentina Rita, de Caro, Francesca, Delcogliano, Marco, di Laura Frattura, Giorgio, Di Vico, Giovanni, Manunta, Andrea Fabio, Russo, Arcangelo, and Filardo, Giuseppe

Published
2023
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22. The Psychological Science Accelerator’s COVID-19 rapid-response dataset

Author

Buchanan, Erin M., Lewis, Savannah C., Paris, Bastien, Forscher, Patrick S., Pavlacic, Jeffrey M., Beshears, Julie E., Drexler, Shira Meir, Gourdon-Kanhukamwe, Amélie, Mallik, Peter R, Silan, Miguel Alejandro A., Miller, Jeremy K., IJzerman, Hans, Moshontz, Hannah, Beaudry, Jennifer L., Suchow, Jordan W., Chartier, Christopher R., Coles, Nicholas A., Sharifian, MohammadHasan, Todsen, Anna Louise, Levitan, Carmel A., Azevedo, Flávio, Legate, Nicole, Heller, Blake, Rothman, Alexander J., Dorison, Charles A., Gill, Brian P., Wang, Ke, Rees, Vaughan W., Gibbs, Nancy, Goldenberg, Amit, Thi Nguyen, Thuy-vy, Gross, James J., Kaminski, Gwenaêl, von Bastian, Claudia C., Paruzel-Czachura, Mariola, Mosannenzadeh, Farnaz, Azouaghe, Soufian, Bran, Alexandre, Ruiz-Fernandez, Susana, Santos, Anabela Caetano, Reggev, Niv, Zickfeld, Janis H., Akkas, Handan, Pantazi, Myrto, Ropovik, Ivan, Korbmacher, Max, Arriaga, Patrícia, Gjoneska, Biljana, Warmelink, Lara, Alves, Sara G., de Holanda Coelho, Gabriel Lins, Stieger, Stefan, Schei, Vidar, Hanel, Paul H. P., Szaszi, Barnabas, Fedotov, Maksim, Antfolk, Jan, Marcu, Gabriela-Mariana, Schrötter, Jana, Kunst, Jonas R., Geiger, Sandra J., Adetula, Adeyemi, Kocalar, Halil Emre, Kielińska, Julita, Kačmár, Pavol, Bokkour, Ahmed, Galindo-Caballero, Oscar J., Djamai, Ikhlas, Pöntinen, Sara Johanna, AGESIN, Bamikole Emmanuel, Jernsäther, Teodor, Urooj, Anum, Rachev, Nikolay R., Koptjevskaja-Tamm, Maria, Kurfalı, Murathan, Pit, Ilse L., Li, Ranran, Çoksan, Sami, Dubrov, Dmitrii, Paltrow, Tamar Elise, Baník, Gabriel, Korobova, Tatiana, Studzinska, Anna, Jiang, Xiaoming, Aruta, John Jamir Benzon R., Vintr, Jáchym, Chiu, Faith, Kaliska, Lada, Berkessel, Jana B., Tümer, Murat, Morales-Izquierdo, Sara, Chuan-Peng, Hu, Vezirian, Kevin, Rosa, Anna Dalla, Bialobrzeska, Olga, Vasilev, Martin R., Beitner, Julia, Kácha, Ondřej, Žuro, Barbara, Westerlund, Minja, Nedelcheva-Datsova, Mina, Findor, Andrej, Krupić, Dajana, Kowal, Marta, Askelund, Adrian Dahl, Pourafshari, Razieh, Đorđević, Jasna Milošević, Schmidt, Nadya-Daniela, Baklanova, Ekaterina, Szala, Anna, Zakharov, Ilya, Vranka, Marek A., Ihaya, Keiko, Grano, Caterina, Cellini, Nicola, Białek, Michał, Anton-Boicuk, Lisa, Dalgar, Ilker, Adıgüzel, Arca, Verharen, Jeroen P. H., Maturan, Princess Lovella G., Kassianos, Angelos P., Oliveira, Raquel, Čadek, Martin, Adoric, Vera Cubela, Özdoğru, Asil Ali, Sverdrup, Therese E., Aczel, Balazs, Zambrano, Danilo, Ahmed, Afroja, Tamnes, Christian K., Yamada, Yuki, Volz, Leonhard, Sunami, Naoyuki, Suter, Lilian, Vieira, Luc, Groyecka-Bernard, Agata, Kamburidis, Julia Arhondis, Reips, Ulf-Dietrich, Harutyunyan, Mikayel, Adetula, Gabriel Agboola, Allred, Tara Bulut, Barzykowski, Krystian, Antazo, Benedict G, Zsido, Andras N., Šakan, Dušana Dušan, Cyrus-Lai, Wilson, Ahlgren, Lina Pernilla, Hruška, Matej, Vega, Diego, Manunta, Efisio, Mokady, Aviv, Capizzi, Mariagrazia, Martončik, Marcel, Say, Nicolas, Filip, Katarzyna, Vilar, Roosevelt, Staniaszek, Karolina, Vdovic, Milica, Adamkovic, Matus, Johannes, Niklas, Hajdu, Nandor, Cohen, Noga, Overkott, Clara, Krupić, Dino, Hubena, Barbora, Nilsonne, Gustav, Mioni, Giovanna, Solorzano, Claudio Singh, Ishii, Tatsunori, Chen, Zhang, Kushnir, Elizaveta, Karaarslan, Cemre, Ribeiro, Rafael R., Khaoudi, Ahmed, Kossowska, Małgorzata, Bavolar, Jozef, Hoyer, Karlijn, Roczniewska, Marta, Karababa, Alper, Becker, Maja, Monteiro, Renan P., Kunisato, Yoshihiko, Metin-Orta, Irem, Adamus, Sylwia, Kozma, Luca, Czarnek, Gabriela, Domurat, Artur, Štrukelj, Eva, Alvarez, Daniela Serrato, Parzuchowski, Michal, Massoni, Sébastien, Czamanski-Cohen, Johanna, Pronizius, Ekaterina, Muchembled, Fany, van Schie, Kevin, Saçaklı, Aslı, Hristova, Evgeniya, Kuzminska, Anna O., Charyate, Abdelilah, Bijlstra, Gijsbert, Afhami, Reza, Majeed, Nadyanna M., Musser, Erica D., Sirota, Miroslav, Ross, Robert M., Yeung, Siu Kit, Papadatou-Pastou, Marietta, Foroni, Francesco, Almeida, Inês A. T., Grigoryev, Dmitry, Lewis, David M. G., Holford, Dawn L., Janssen, Steve M. J., Tatachari, Srinivasan, Batres, Carlota, Olofsson, Jonas K., Daches, Shimrit, Belaus, Anabel, Pfuhl, Gerit, Corral-Frias, Nadia Sarai, Sousa, Daniela, Röer, Jan Philipp, Isager, Peder Mortvedt, Godbersen, Hendrik, Walczak, Radoslaw B., Van Doren, Natalia, Ren, Dongning, Gill, Tripat, Voracek, Martin, DeBruine, Lisa M., Anne, Michele, Očovaj, Sanja Batić, Thomas, Andrew G., Arvanitis, Alexios, Ostermann, Thomas, Wolfe, Kelly, Arinze, Nwadiogo Chisom, Bundt, Carsten, Lamm, Claus, Calin-Jageman, Robert J, Davis, William E., Karekla, Maria, Zorjan, Saša, Jaremka, Lisa M., Uttley, Jim, Hricova, Monika, Koehn, Monica A, Kiselnikova, Natalia, Bai, Hui, Krafnick, Anthony J., Balci, Busra Bahar, Ballantyne, Tonia, Lins, Samuel, Vally, Zahir, Esteban-Serna, Celia, Schmidt, Kathleen, Macapagal, Paulo Manuel L., Szwed, Paulina, Zdybek, Przemysław Marcin, Moreau, David, Collins, W. Matthew, Joy-Gaba, Jennifer A., Vilares, Iris, Tran, Ulrich S., Boudesseul, Jordane, Albayrak-Aydemir, Nihan, Dixson, Barnaby James Wyld, Perillo, Jennifer T, Ferreira, Ana, Westgate, Erin C., Aberson, Christopher L., Arinze, Azuka Ikechukwu, Jaeger, Bastian, Butt, Muhammad Mussaffa, Silva, Jaime R., Storage, Daniel Shafik, Janak, Allison P, Jiménez-Leal, William, Soto, Jose A., Sorokowska, Agnieszka, McCarthy, Randy, Tullett, Alexa M, Frias-Armenta, Martha, Ribeiro, Matheus Fernando Felix, Hartanto, Andree, Forbes, Paul A. G., Willis, Megan L., del Carmen Tejada R, María, Torres, Adriana Julieth Olaya, Stephen, Ian D, Vaidis, David C., de la Rosa-Gómez, Anabel, Yu, Karen, Sutherland, Clare A. M., Manavalan, Mathi, Behzadnia, Behzad, Urban, Jan, Baskin, Ernest, McFall, Joseph P., Ogbonnaya, Chisom Esther, Fu, Cynthia H. Y., Rahal, Rima-Maria, Ndukaihe, Izuchukwu L. G., Hostler, Thomas J., Kappes, Heather Barry, Sorokowski, Piotr, Khosla, Meetu, Lazarevic, Ljiljana B., Eudave, Luis, Vilsmeier, Johannes K., Luis, Elkin O., Muda, Rafał, Agadullina, Elena, Cárcamo, Rodrigo A., Reeck, Crystal, Anjum, Gulnaz, Venegas, Mónica Camila Toro, Misiak, Michal, Ryan, Richard M., Nock, Nora L., Travaglino, Giovanni A., Mensink, Michael C., Feldman, Gilad, Wichman, Aaron L., Chou, Weilun, Ziano, Ignazio, Seehuus, Martin, Chopik, William J., Kung, Franki Y. H., Carpentier, Joelle, Vaughn, Leigh Ann, Du, Hongfei, Xiao, Qinyu, Lima, Tiago J. S., Noone, Chris, Onie, Sandersan, Verbruggen, Frederick, Radtke, Theda, and Primbs, Maximilian A.

Published
2023
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23. Supporting complexity: the psychologist’s role in multidisciplinary management of polycystic kidney disease

Author

Sara Farinone, Martina Catania, Liliana Italia De Rosa, Kristiana Kola, Micaela Petrone, Matteo Brambilla Pisoni, Andrea Gigliotti, Pierpaolo Bianca, Paola Maiucchi, Lorena Citterio, Paola Carrera, Giulia Mancassola, Gaia Perego, Francesca Milano, Valentina Elisabetta Di Mattei, Paolo Manunta, Giuseppe Vezzoli, and Maria Teresa Sciarrone Alibrandi

Subjects
ADPKD, Patient’s support, Autosomal Dominant Polycystic Kidney Disease, Psychological impact, Internal medicine, RC31-1245, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease. It is characterized by the formation of cysts in kidneys. This condition has a significant impact on people’s lives. It causes not only physical suffering but also psychological suffering. People with ADPKD may experience psychological distress, depending on their personal and health conditions. The inability to accept or adapt to the disease and its resulting changes causes individuals difficulties that appear in different levels of their lives: intrapersonal, interpersonal, social, and occupational. In the context of ADPKD, the psychologist is involved both at clinical and research levels. The psychologist has a crucial role in supporting patients by assessing how they react to the disease, to its related limitations, and to the resulting disabilities. The proposal of psychological support, considered as an intervention instrument, is helpful both at the diagnostic stage and in follow-up, as the disease worsens. The support aims to encourage acceptance and adaptation to the disease, process changes, and physical and mental consequences.

Published
2024
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24. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori., Andrea, Bandera, Alessandra, Muscatello, Antonio, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi., Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Renisi, Giulia, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Viero, Giulia, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Peyvandi, Flora, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero., Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili., Alessandro, Tettamanti, Mauro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, Leone, Sara, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Azzarà, Cecilia, Mantero, Marco, Bassetti, Matteo, Marchetti, Giulia, Nobili, Alessandro, and Gori, Andrea

Published
2024
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30. Techniques for Structural Assessment Based on MT-DInSAR Data, Applied to the San Michele Complex in Rome

Author

Talledo, Diego, Stella, Alberto, Bonano, Manuela, Di Carlo, Fabio, Lanari, Riccardo, Manunta, Michele, Meda, Alberto, Mele, Annalisa, Miano, Andrea, Prota, Andrea, Saetta, Anna, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Rizzo, Piervincenzo, editor, and Milazzo, Alberto, editor

Published
2023
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31. The Use of MT-DInSAR Data for the Safety Assessment and Monitoring of Structures and Infrastructures: The Case Study of 'Torri Stellari' in Rome

Author

Miano, Andrea, Mele, Annalisa, Bonano, Manuela, Di Carlo, Fabio, Lanari, Riccardo, Manunta, Michele, Meda, Alberto, Prota, Andrea, Saetta, Anna, Stella, Alberto, Talledo, Diego, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Rizzo, Piervincenzo, editor, and Milazzo, Alberto, editor

Published
2023
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35. Folic acid supplementation use during the peri-conceptional period among professionals of a hospital in France

Author

Pauline Blanc-Petitjean, Magali Jézequel, Andrea Manunta, Camille Olivari-Philiponnet, Emmanuelle Samson, and Emma Bajeux

Subjects
Folate, Folic acid, Dietary supplements, Preconception care, Pregnancy, Medicine
Abstract

Folic acid insufficiency is an important risk factor for congenital neural tube defects. Despite recommendations and national campaigns, the proportion of women taking folic acid in the peri-conceptional period remains insufficient worldwide. We describe in this study the proportion of peri-conceptional folic acid supplementation use and its determinants among a population of hospital workers during the course of a prevention campaign. We performed a single-center cross sectional study in a university hospital in France. Data were collected during 2 months in 2019 by an online questionnaire sent to all professionals. We collected information about folic acid supplementation use, its modalities (form, period, frequency and dosage) and reason for initiating or not supplementation. Response rate was 11.4 % (n = 1,075/9,447). Among the 748 women who reported at least one pregnancy, 72.7 % (95 % CI: 69.4–76.0 %) reported taking folic acid during their last pregnancy. Main reason for initiating supplementation was information given by a health professional (87.8 %), especially by gynaecologists-obstetricians. Principal factors associated with folic acid supplementation use were age between 25 and 35 years, high level of education and recent pregnancy. Folic acid supplementation use is still not systematic before and during pregnancy, even among health professionals. There is a case for mandatory folic acid fortification for the French general population.

Published
2024
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37. The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic

Author

Marta Canuti, Maria Cristina Monti, Chiara Bobbio, Antonio Muscatello, Toussaint Muheberimana, Sante Leandro Baldi, Francesco Blasi, Ciro Canetta, Giorgio Costantino, Alessandro Nobili, Flora Peyvandi, Mauro Tettamanti, Simone Villa, Stefano Aliberti, Mario C. Raviglione, Andrea Gori, Alessandra Bandera, COVID-19 Network Study Group, Bosari Silvano, Scudeller Luigia, Fusetti Giuliana, Rusconi Laura, Dell’Orto Silvia, Prati Daniele, Valenti Luca, Giovannelli Silvia, Manunta Maria, Lamorte Giuseppe, Ferarri Francesca, Mangioni Davide, Alagna Laura, Bozzi Giorgio, Lombardi Andrea, Ungaro Riccardo, Ancona Giuseppe, Zuglian Gianluca, Bolis Matteo, Iannotti Nathalie, Ludovisi Serena, Comelli Agnese, Renisi Giulia, Biscarini Simona, Castelli Valeria, Palomba Emanuele, Fava Marco, Fortina Valeria, Liparoti Arianna, Pastena Andrea, Alberto Peri Carlo, Saltini Paola, Viero Giulia, Itri Teresa, Ferroni Valentina, Pastore Valeria, Massafra Roberta, Curri Maria Teresa, Rizzo Alice, Scarpa Stefano, Giommi Alessandro, Bianco Rosaria, Chitani Grazia Eliana, Gualtierotti Roberta, Ferrari Barbara, Rossio Raffaella, Boasi Nadia, Pagliaro Erica, Massimo Costanza, Caro Michele De, Giachi Andrea, Montano Nicola, Vigone Barbara, Bellocchi Chiara, Carandina Angelica, Fiorelli Elisa, Melli Valerie, Tobaldini Eleonora, Spotti Maura, Terranova Leonardo, Misuraca Sofia, D’Adda Alice, Fiore Silvia Della, Pasquale Marta Di, Mantero Marco, Contarini Martina, Ori Margherita, Morlacchi Letizia, Rossetti Valeria, Gramegna Andrea, Pappalettera Maria, Cavallini Mirta, Buscemi Agata, Vicenzi Marco, Rota Irena, Solbiati Monica, Furlan Ludovico, Mancarella Marta, Colombo Giulia, Colombo Giorgio, Fanin Alice, Passarella Mariele, Monzani Valter, Rovellini Angelo, Barbetta Laura, Billi Filippo, Folli Christian, Accordino Silvia, Maira Diletta, Hu Cinzia Maria, Motta Irene, Scaramellini Natalia, Fracanzani Anna Ludovica, Lombardi Rosa, Cespiati Annalisa, Cesari Matteo, Lucchi Tiziano, Proietti Marco, Calcaterra Laura, Mandelli Clara, Coppola Carlotta, Cerizza Arturo, Grasselli Giacomo, Galazzi Alessandro, Monti Igor, and Galbusera Alessia Antonella

Subjects
SARS-CoV-2, COVID-19, disease outcome, hospitalization, COVID-19 vaccination, immune suppression, Medicine (General), R5-920
Abstract

Specific immune suppression types have been associated with a greater risk of severe COVID-19 disease and death. We analyzed data from patients >17 years that were hospitalized for COVID-19 at the “Fondazione IRCCS Ca′ Granda Ospedale Maggiore Policlinico” in Milan (Lombardy, Northern Italy). The study included 1727 SARS-CoV-2-positive patients (1,131 males, median age of 65 years) hospitalized between February 2020 and November 2022. Of these, 321 (18.6%, CI: 16.8–20.4%) had at least one condition defining immune suppression. Immune suppressed subjects were more likely to have other co-morbidities (80.4% vs. 69.8%, p

Published
2023
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38. Automatic seismic source modeling of InSAR displacements

Author

Simone Atzori, Fernando Monterroso, Andrea Antonioli, Claudio De Luca, Nikos Svigkas, Francesco Casu, Michele Manunta, Matteo Quintiliani, and Riccardo Lanari

Subjects
InSAR, Earthquake modeling, Real-time analysis, Automatic processing, Fault scaling factors, Data analysis, Physical geography, GB3-5030, Environmental sciences, GE1-350
Abstract

In this work we describe the implementation of a processing chain for a fully automatic modeling of the seismic source parameters and its slip distribution through the inversion of the InSAR displacements generated from the EPOSAR service. This processing chain consists of a suite of procedures and algorithms handling a sequence of steps: selection of the highest quality InSAR datasets, definition of the area of interest, image sampling, non-linear and linear inversions to get, respectively, the source geometry and its slip distribution. A set of side procedures and interfaces also allows an interactive refinement and the publication of results, consisting of scientific data and graphical outputs. The whole procedure has been developed, tested and validated by considering 100 events with magnitudes between 5.5 and 8.2, worldwide distributed and covering an exhaustive range of mechanisms and tectonic contexts.Main aim of this work is describing the implementation of the automatic modeling procedures, used to produce solutions in real time, already during the emergency phase. These sources, validated by experts before their publication, can be a reference for operational purposes and initial scientific analyses. The creation of this repository sets also the framework to store, out of the emergency time, more sophisticated solutions, manually revised and/or with peer-review quality.

Published
2023
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41. The Psychological Science Accelerator’s COVID-19 rapid-response dataset

Author

Erin M. Buchanan, Savannah C. Lewis, Bastien Paris, Patrick S. Forscher, Jeffrey M. Pavlacic, Julie E. Beshears, Shira Meir Drexler, Amélie Gourdon-Kanhukamwe, Peter R Mallik, Miguel Alejandro A. Silan, Jeremy K. Miller, Hans IJzerman, Hannah Moshontz, Jennifer L. Beaudry, Jordan W. Suchow, Christopher R. Chartier, Nicholas A. Coles, MohammadHasan Sharifian, Anna Louise Todsen, Carmel A. Levitan, Flávio Azevedo, Nicole Legate, Blake Heller, Alexander J. Rothman, Charles A. Dorison, Brian P. Gill, Ke Wang, Vaughan W. Rees, Nancy Gibbs, Amit Goldenberg, Thuy-vy Thi Nguyen, James J. Gross, Gwenaêl Kaminski, Claudia C. von Bastian, Mariola Paruzel-Czachura, Farnaz Mosannenzadeh, Soufian Azouaghe, Alexandre Bran, Susana Ruiz-Fernandez, Anabela Caetano Santos, Niv Reggev, Janis H. Zickfeld, Handan Akkas, Myrto Pantazi, Ivan Ropovik, Max Korbmacher, Patrícia Arriaga, Biljana Gjoneska, Lara Warmelink, Sara G. Alves, Gabriel Lins de Holanda Coelho, Stefan Stieger, Vidar Schei, Paul H. P. Hanel, Barnabas Szaszi, Maksim Fedotov, Jan Antfolk, Gabriela-Mariana Marcu, Jana Schrötter, Jonas R. Kunst, Sandra J. Geiger, Adeyemi Adetula, Halil Emre Kocalar, Julita Kielińska, Pavol Kačmár, Ahmed Bokkour, Oscar J. Galindo-Caballero, Ikhlas Djamai, Sara Johanna Pöntinen, Bamikole Emmanuel AGESIN, Teodor Jernsäther, Anum Urooj, Nikolay R. Rachev, Maria Koptjevskaja-Tamm, Murathan Kurfalı, Ilse L. Pit, Ranran Li, Sami Çoksan, Dmitrii Dubrov, Tamar Elise Paltrow, Gabriel Baník, Tatiana Korobova, Anna Studzinska, Xiaoming Jiang, John Jamir Benzon R. Aruta, Jáchym Vintr, Faith Chiu, Lada Kaliska, Jana B. Berkessel, Murat Tümer, Sara Morales-Izquierdo, Hu Chuan-Peng, Kevin Vezirian, Anna Dalla Rosa, Olga Bialobrzeska, Martin R. Vasilev, Julia Beitner, Ondřej Kácha, Barbara Žuro, Minja Westerlund, Mina Nedelcheva-Datsova, Andrej Findor, Dajana Krupić, Marta Kowal, Adrian Dahl Askelund, Razieh Pourafshari, Jasna Milošević Đorđević, Nadya-Daniela Schmidt, Ekaterina Baklanova, Anna Szala, Ilya Zakharov, Marek A. Vranka, Keiko Ihaya, Caterina Grano, Nicola Cellini, Michał Białek, Lisa Anton-Boicuk, Ilker Dalgar, Arca Adıgüzel, Jeroen P. H. Verharen, Princess Lovella G. Maturan, Angelos P. Kassianos, Raquel Oliveira, Martin Čadek, Vera Cubela Adoric, Asil Ali Özdoğru, Therese E. Sverdrup, Balazs Aczel, Danilo Zambrano, Afroja Ahmed, Christian K. Tamnes, Yuki Yamada, Leonhard Volz, Naoyuki Sunami, Lilian Suter, Luc Vieira, Agata Groyecka-Bernard, Julia Arhondis Kamburidis, Ulf-Dietrich Reips, Mikayel Harutyunyan, Gabriel Agboola Adetula, Tara Bulut Allred, Krystian Barzykowski, Benedict G Antazo, Andras N. Zsido, Dušana Dušan Šakan, Wilson Cyrus-Lai, Lina Pernilla Ahlgren, Matej Hruška, Diego Vega, Efisio Manunta, Aviv Mokady, Mariagrazia Capizzi, Marcel Martončik, Nicolas Say, Katarzyna Filip, Roosevelt Vilar, Karolina Staniaszek, Milica Vdovic, Matus Adamkovic, Niklas Johannes, Nandor Hajdu, Noga Cohen, Clara Overkott, Dino Krupić, Barbora Hubena, Gustav Nilsonne, Giovanna Mioni, Claudio Singh Solorzano, Tatsunori Ishii, Zhang Chen, Elizaveta Kushnir, Cemre Karaarslan, Rafael R. Ribeiro, Ahmed Khaoudi, Małgorzata Kossowska, Jozef Bavolar, Karlijn Hoyer, Marta Roczniewska, Alper Karababa, Maja Becker, Renan P. Monteiro, Yoshihiko Kunisato, Irem Metin-Orta, Sylwia Adamus, Luca Kozma, Gabriela Czarnek, Artur Domurat, Eva Štrukelj, Daniela Serrato Alvarez, Michal Parzuchowski, Sébastien Massoni, Johanna Czamanski-Cohen, Ekaterina Pronizius, Fany Muchembled, Kevin van Schie, Aslı Saçaklı, Evgeniya Hristova, Anna O. Kuzminska, Abdelilah Charyate, Gijsbert Bijlstra, Reza Afhami, Nadyanna M. Majeed, Erica D. Musser, Miroslav Sirota, Robert M. Ross, Siu Kit Yeung, Marietta Papadatou-Pastou, Francesco Foroni, Inês A. T. Almeida, Dmitry Grigoryev, David M. G. Lewis, Dawn L. Holford, Steve M. J. Janssen, Srinivasan Tatachari, Carlota Batres, Jonas K. Olofsson, Shimrit Daches, Anabel Belaus, Gerit Pfuhl, Nadia Sarai Corral-Frias, Daniela Sousa, Jan Philipp Röer, Peder Mortvedt Isager, Hendrik Godbersen, Radoslaw B. Walczak, Natalia Van Doren, Dongning Ren, Tripat Gill, Martin Voracek, Lisa M. DeBruine, Michele Anne, Sanja Batić Očovaj, Andrew G. Thomas, Alexios Arvanitis, Thomas Ostermann, Kelly Wolfe, Nwadiogo Chisom Arinze, Carsten Bundt, Claus Lamm, Robert J Calin-Jageman, William E. Davis, Maria Karekla, Saša Zorjan, Lisa M. Jaremka, Jim Uttley, Monika Hricova, Monica A Koehn, Natalia Kiselnikova, Hui Bai, Anthony J. Krafnick, Busra Bahar Balci, Tonia Ballantyne, Samuel Lins, Zahir Vally, Celia Esteban-Serna, Kathleen Schmidt, Paulo Manuel L. Macapagal, Paulina Szwed, Przemysław Marcin Zdybek, David Moreau, W. Matthew Collins, Jennifer A. Joy-Gaba, Iris Vilares, Ulrich S. Tran, Jordane Boudesseul, Nihan Albayrak-Aydemir, Barnaby James Wyld Dixson, Jennifer T Perillo, Ana Ferreira, Erin C. Westgate, Christopher L. Aberson, Azuka Ikechukwu Arinze, Bastian Jaeger, Muhammad Mussaffa Butt, Jaime R. Silva, Daniel Shafik Storage, Allison P Janak, William Jiménez-Leal, Jose A. Soto, Agnieszka Sorokowska, Randy McCarthy, Alexa M Tullett, Martha Frias-Armenta, Matheus Fernando Felix Ribeiro, Andree Hartanto, Paul A. G. Forbes, Megan L. Willis, María del Carmen Tejada R, Adriana Julieth Olaya Torres, Ian D Stephen, David C. Vaidis, Anabel de la Rosa-Gómez, Karen Yu, Clare A. M. Sutherland, Mathi Manavalan, Behzad Behzadnia, Jan Urban, Ernest Baskin, Joseph P. McFall, Chisom Esther Ogbonnaya, Cynthia H. Y. Fu, Rima-Maria Rahal, Izuchukwu L. G. Ndukaihe, Thomas J. Hostler, Heather Barry Kappes, Piotr Sorokowski, Meetu Khosla, Ljiljana B. Lazarevic, Luis Eudave, Johannes K. Vilsmeier, Elkin O. Luis, Rafał Muda, Elena Agadullina, Rodrigo A. Cárcamo, Crystal Reeck, Gulnaz Anjum, Mónica Camila Toro Venegas, Michal Misiak, Richard M. Ryan, Nora L. Nock, Giovanni A. Travaglino, Michael C. Mensink, Gilad Feldman, Aaron L. Wichman, Weilun Chou, Ignazio Ziano, Martin Seehuus, William J. Chopik, Franki Y. H. Kung, Joelle Carpentier, Leigh Ann Vaughn, Hongfei Du, Qinyu Xiao, Tiago J. S. Lima, Chris Noone, Sandersan Onie, Frederick Verbruggen, Theda Radtke, and Maximilian A. Primbs

Subjects
Science
Abstract

Measurement(s) COVID-19 Protocols, Restrictions • Health Behaviors • Personality and Behavioral Change, CTCAE • Emotion • Message Framing • Self-Determination Technology Type(s) Survey • Experiment Design Type Factor Type(s) COVID-19 Protocols, Restrictions • Health Behaviors • Loss-Gain Framing • Cognitive Reappraisal • Self-Determination Messaging Sample Characteristic - Organism Homo Sample Characteristic - Environment Daily Life Sample Characteristic - Location North America • South America • Africa • Australia • Europe • United Kingdom • Asia

Published
2023
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42. Automated classification of A-DInSAR-based ground deformation by using random forest

Author

Davide Festa, Nicola Casagli, Francesco Casu, Pierluigi Confuorto, Claudio De Luca, Matteo Del Soldato, Riccardo Lanari, Michele Manunta, Mariarosaria Manzo, and Federico Raspini

Subjects
ground deformation, a-dinsar, machine learning, random forest, automated classification, Mathematical geography. Cartography, GA1-1776, Environmental sciences, GE1-350
Abstract

Wide-area ground motion monitoring is nowadays achievable via advanced Differential Interferometry SAR (A-DInSAR) techniques which benefit from the availability of large sets of Copernicus Sentinel-1 images. However, it is of primary importance to implement automated solutions aimed at performing integrated analysis of large amounts of interferometric data. To effectively detect high-displacement areas and classify ground motion sources, here we explore the feasibility of a machine learning-based approach. This is achieved by applying the random forest (RF) technique to large-scale deformation maps spanning 2015–2018. Focusing on the northern part of Italy, we train the model to identify landslide, subsidence, and mining-related ground motion with which to construct a balanced training dataset. The presence of noisy signals and other sources of deformation is also tackled within the model construction. The proposed approach relies on the use of explanatory variables extracted from the A-DInSAR datasets and from freely accessible informative layers such as Digital Elevation Model (DEM), land cover maps, and geohazard inventories. In general, the model performance is very promising as we achieved an overall accuracy of 0.97, a true positive rate of 0.94 and an F1-Score of 0.93. The obtained outcomes demonstrate that such transferable and automated approach may constitute an asset for stakeholders in the framework of geohazards risk management.

Published
2022
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44. Recommandations sur la gestion du risque et la prise en charge urologique du patient adulte atteint de dysraphisme spinal (spina bifida)

Author

Manunta, A., Peyronnet, B., Olivari-Philiponnet, C., Chartier-Kastler, E., Saussine, C., Phé, V., Robain, G., Denys, P., Even, A., Samson, E., Grise, P., Karsenty, G., Hascoet, J., Castel-Lacanal, E., Charvier, K., Guinet-Lacoste, A., Chesnel, C., Amarenco, G., Haffner, F., Haddad, M., Le Normand, L., Perrouin-Verbe, M.-A., Perrouin-Verbe, B., De Seze, M., Ruffion, A., and Gamé, X.

Published
2023
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45. In COVID-19 Health Messaging, Loss Framing Increases Anxiety with Little-to-No Concomitant Benefits: Experimental Evidence from 84 Countries

Author

Dorison, Charles A., Lerner, Jennifer S., Heller, Blake H., Rothman, Alexander J., Kawachi, Ichiro I., Wang, Ke, Rees, Vaughan W., Gill, Brian P., Gibbs, Nancy, Ebersole, Charles R., Vally, Zahir, Tajchman, Zuzanna, Zsido, Andras N., Zrimsek, Mija, Chen, Zhang, Ziano, Ignazio, Gialitaki, Zoi, Ceary, Chris D., Lin, Yijun, Kunisato, Yoshihiko, Yamada, Yuki, Xiao, Qinyu, Jiang, Xiaoming, Du, Xinkai, Yao, Elvin, Wilson, John Paul, Cyrus-Lai, Wilson, Jimenez-Leal, William, Law, Wilbert, Collins, W. Matthew, Richard, Karley L., Vranka, Marek, Ankushev, Vladislav, Schei, Vidar, Križanić, Valerija, Kadreva, Veselina Hristova, Adoric, Vera Cubela, Tran, Ulrich S., Yeung, Siu Kit, Hassan, Widad, Houston, Ralph, Lima, Tiago J. S., Ostermann, Thomas, Frizzo, Thomas, Sverdrup, Therese E., House, Thea, Gill, Tripat, Fedotov, Maksim, Paltrow, Tamar, Jernsäther, Teodor, Koptjevskaja-Tamm, Maria, Hostler, Thomas J., Ishii, Tatsunori, Szaszi, Barnabas, Adamus, Sylwia, Suter, Lilian, Habib, Sumaiya, Studzinska, Anna, Stojanovska, Dragana, Janssen, Steve M. J., Stieger, Stefan, Schulenberg, Stefan E., Tatachari, Srinivasan, Azouaghe, Soufian, Sorokowski, Piotr, Sorokowska, Agnieszka, Song, Xin, Lewis, Savannah C., Sinkolova, Sladjana, Grigoryev, Dmitry, Drexler, Shira Meir, Daches, Shimrit, Geniole, Shawn N., Vračar, Selena, Massoni, Sébastien, Zorjan, Saša, Sarıoğuz, Eylül, Izquierdo, Sara Morales, Alves, Sara G., Pöntinen, Sara, Solas, Sara Álvarez, Ordoñez-Riaño, Santiago, Očovaj, Sanja Batić, Onie, Sandersan, Lins, Samuel, Çoksan, Sami, Sacakli, Asli, Ruiz-Fernández, Susana, Geiger, Sandra J., FatahModares, Saeideh, Walczak, Radoslaw B., Betlehem, Ruben, Vilar, Roosevelt, Cárcamo, Rodrigo, Ross, Robert M., McCarthy, Randy, Ballantyne, Tonia, Westgate, Erin C., Afhami, Reza, Ren, Dongning, Monteiro, Renan P., Reips, Ulf-Dietrich, Reggev, Niv, Calin-Jageman, Robert J., Pourafshari, Razieh, Oliveira, Raquel, Nedelcheva-Datsova, Mina, Rahal, Rima-Maria, Ribeiro, Rafael R., Radtke, Theda, Searston, Rachel, Habte, Redeate, Zdybek, Przemysław, Chen, Sau-Chin, Maturan, Princess Lovella G., Perillo, Jennifer T., Isager, Peder Mortvedt, Kačmár, Pavol, Macapagal, Paulo Manuel, Szwed, Paulina, Hanel, Paul H. P., Forbes, Paul A. G., Arriaga, Patrícia, Paris, Bastien, Papachristopoulos, Konstantinos, Correa, Pablo Sebastián, Kácha, Ondřej, Bernardo, Márcia, Campos, Olatz, Bravo, Olalla Niño, Galindo-Caballero, Oscar J., Ogbonnaya, Chisom Esther, Bialobrzeska, Olga, Kiselnikova, Natalia, Simonovic, Nicolle, Cohen, Noga, Nock, Nora L., Johannes, Niklas, Albayrak-Aydemir, Nihan, Say, Nicolas, Torunsky, Nathan, Van Doren, Natalia, Sunami, Naoyuki, Rachev, Nikolay R., Majeed, Nadyanna M., Schmidt, Nadya-Daniela, Nadif, Khaoula, Corral-Frías, Nadia S., Ouherrou, Nihal, Pantazi, Myrto, Lucas, Marc Y., Vasilev, Martin R., Ortiz, María Victoria, Butt, Muhammad Mussaffa, Kabir, Muhib, Muda, Rafał, Tejada Rivera, Maria del Carmen MC, Sirota, Miroslav, Seehuus, Martin, Parzuchowski, Michal, Toro, Mónica, Hricova, Monika, Maldonado, Mónica Alarcón, Marszalek, Magdalena, Karekla, Maria, Mioni, Giovanna, Bosma, Minke Jasmijn, Westerlund, Minja, Vdovic, Milica, Bialek, Michal, Silan, Miguel A., Anne, Michele, Misiak, Michal, Grinberg, Maurice, Capizzi, Mariagrazia, Espinoza Barría, Mauricio F., Kurfali, Merve A., Mensink, Michael C., Harutyunyan, Mikayel, Khosla, Meetu, Korbmacher, Max, Adamkovič, Matúš, Ribeiro, Matheus Fernando Felix, Terskova, Maria, Hruška, Matej, Martončik, Marcel, Voracek, Martin, Čadek, Martin, Frías-Armenta, Martha, Kowal, Marta, Topor, Marta, Roczniewska, Marta, Oosterlinck, Marlies, Kohlová, Markéta Braun, Paruzel-Czachura, Mariola, Romanova, Marina, Papadatou-Pastou, Marietta, Lund, Maria Louise, Antoniadi, Maria, Jones, Marc V., Ortiz, Manuel S., Manavalan, Mathi, Muminov, Abdumalik, Kossowska, Małgorzata, Friedemann, Maja, Wielgus, Magdalena, Varella, Marco A. C., Colloff, Melissa F., Bradford, Maria, Vaughn, Leigh Ann, Eudave, Luis, Vieira, Luc, Pineda, Lina Maria Sanabria, Pérez, Laura Calderón, Lazarevic, Ljiljana B., Jaremka, Lisa M., Kushnir, Elizaveta, Anton-Boicuk, Lisa, de Holanda Coelho, Gabriel Lins, Ahlgren, Lina, Levitan, Carmel A., Micheli, Leticia, Volz, Leonhard, Stojanovska, Marija, Boucher, Leanne, Samojlenko, Lara, Delgado, Lady Grey Javela, Kaliska, Lada, Warmelink, Lara, Rojas-Berscia, Luis Miguel, Yu, Karen, Wachowicz, Jakub, Desai, Kermeka, Barzykowski, Krystian, Kozma, Luca, Evans, Kortnee, Kirgizova, Komila, Agesin, Bamikole Emmanuel, Koehn, Monica A, Wolfe, Kelly, Korobova, Tatiana, Klevjer, Kristoffer, van Schie, Kevin, Vezirian, Kevin, Damnjanović, Kaja, Thommesen, Katrine Krabbe, Schmidt, Kathleen, Filip, Katarzyna, Grzech, Karolina, Hoyer, Karlijn, Moon, Karis, Rana, Kafeel, Janjić, Kristina, Suchow, Jordan W., Kielińska, Julita, Cruz Vásquez, Julio E, Beitner, Julia, Vargas-Nieto, Juan Camilo, Roxas, Jose Carlos T., Taber, Jennifer, Urriago-Rayo, Joan, Pavlacic, Jeffrey M., Bavolar, Jozef, Soto, José A., Olofsson, Jonas K., Vilsmeier, Johannes K., Messerschmidt, Johanna, Czamanski-Cohen, Johanna, Boudesseul, Jordane, Lee, Jeong Min, Kamburidis, Julia, Zickfeld, Janis, Miranda, Jacob F., Verharen, Jeroen P. H., Hristova, Evgeniya, Beshears, Julie E., Đorđević, Jasna Milošević, Bosch, Jasmijn, Valentova, Jaroslava Varella, Antfolk, Jan, Berkessel, Jana B., Schrötter, Jana, Urban, Jan, Röer, Jan Philipp, Norton, James O, Silva, Jaime R., Pickering, Jade S., Vintr, Jáchym, Uttley, Jim, Kunst, Jonas R., Ndukaihe, Izuchukwu L. G., Iyer, Aishwarya, Vilares, Iris, Ivanov, Aleksandr, Ropovik, Ivan, Sula, Isabela, Sarieva, Irena, Metin-Orta, Irem, Prusova, Irina, Pinto, Isabel, Bozdoc, Andreea Ioana, Almeida, Inês A. T., Pit, Ilse L., Dalgar, Ilker, Zakharov, Ilya, Arinze, Azuka Ikechukwu, Ihaya, Keiko, Stephen, Ian D., Gjoneska, Biljana, Brohmer, Hilmar, Flowe, Heather, Godbersen, Hendrik, Kocalar, Halil Emre, Hedgebeth, Mattie V., Chuan-Peng, Hu, Sharifian, MohammadHasan, Manley, Harry, Akkas, Handan, Hajdu, Nandor, Azab, Habiba, Kaminski, Gwenael, Nilsonne, Gustav, Anjum, Gulnaz, Travaglino, Giovanni A., Feldman, Gilad, Pfuhl, Gerit, Czarnek, Gabriela, Marcu, Gabriela Mariana, Hofer, Gabriela, Banik, Gabriel, Adetula, Gabriel Agboola, Bijlstra, Gijsbert, Verbruggen, Frederick, Kung, Franki Y. H., Foroni, Francesco, Singer, Gage, Muchembled, Fany, Azevedo, Flavio, Mosannenzadeh, Farnaz, Marinov, Evelina, Štrukelj, Eva, Etebari, Zahra, Baskin, Ernest, Garcia, Elkin Oswaldo Luis, Musser, Erica, van Steenkiste, I.M.M., Ahn, El Rim, Pronizius, Ekaterina, Jackson, Emily A, Manunta, Efisio, Agadullina, Elena, Šakan, Dušana, Dursun, Pinar, Dujols, Olivier, Dubrov, Dmitrii, Willis, Megan, Tümer, Murat, Beaudry, Jennifer L., Popović, Dora, Dunleavy, Daniel, Djamai, Ikhlas, Krupić, Dino, Vega, Diego, Du, Hongfei, Mola, Débora, Davis, William E., Holford, Dawn Liu, Lewis, David M. G., Vaidis, David C., Ozery, Daphna Hausman, Ricaurte, Danilo Zambrano, Storage, Daniel, Sousa, Daniela, Alvarez, Daniela Serrato, Rosa, Anna Dalla, Krupić, Dajana, Marko, Dafne, Moreau, David, Reeck, Crystal, Correia, Rita C., Whitt, Cassie M., Lamm, Claus, Solorzano, Claudio Singh, von Bastian, Claudia C., Sutherland, Clare AM, Overkott, Clara, Aberson, Christopher L., Wang, Chunhui, Karashiali, Christiana, Noone, Chris, Chiu, Faith, Picciocchi, Chiara, Karaarslan, Cemre, Cellini, Nicola, Esteban-Serna, Celia, Reyna, Cecilia, Batres, Carlota, Li, Ranran, Grano, Caterina, Carpentier, Joelle, Tamnes, Christian K., Fu, Cynthia H.Y., Ishkhanyan, Byurakn, Bylinina, Lisa, Jaeger, Bastian, Bundt, Carsten, Allred, Tara Bulut, Bokkour, Ahmed, Bogatyreva, Natalia, Chopik, William J., Antazo, Benedict, Behzadnia, Behzad, Becker, Maja, Cocco, Beatrice, Chou, Wei-Lun, Hubena, Barbora, Žuro, Barbara, Aczel, Balazs, Baklanova, Ekaterina, Bai, Hui, Balci, Busra Bahar, Babinčák, Peter, Dixson, Barnaby James Wyld, Mokady, Aviv, Kappes, Heather Barry, Atari, Mohammad, Szala, Anna, Szabelska, Anna, Aruta, John Jamir Benzon, Domurat, Artur, Arinze, Nwadiogo Chisom, Modena, Arianna, Adiguzel, Arca, Monajem, Arash, ARABI, Kanza AIT EL, Özdoğru, Asil Ali, Olaya Torres, Adriana Julieth, Theodoropoulou, Andriana, Jurković, Anita Penić, Kassianos, Angelos P., Findor, Andrej, Hartanto, Andree, Thibault Landry, Anais, Ferreira, Ana, Santos, Anabela Caetano, De la Rosa-Gomez, Anabel, Gourdon-Kanhukamwe, Amélie, Todsen, Anna Louise, Karababa, Alper, Janak, Allison, Bran, Alexandre, Tullett, Alexa M., Kuzminska, Anna O., Krafnick, Anthony J, Urooj, Anum, Khaoudi, Ahmed, Ahmed, Afroja, Groyecka-Bernard, Agata, Askelund, Adrian Dahl, Adetula, Adeyemi, Belaus, Anabel, Charyate, Abdelilah Ca, Wichman, Aaron L., Stoyanova, Alina, Greenburgh, Anna, Thomas, Andrew G., Arvanitis, Alexios, Forscher, Patrick S., Mallik, Peter R, Primbs, Maximilian A., Miller, Jeremy K., Moshontz, Hannah, Urry, Heather L., IJzerman, Hans, Basnight-Brown, Dana M., Chartier, Christopher R., Buchanan, Erin M., and Coles, Nicholas A.

Published
2022
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46. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Lombardi, A, Villa, S, Colaneri, M, Scaglione, G, Bai, F, Varisco, B, Bono, V, Vena, A, Dentone, C, Russo, C, Tettamanti, M, Renisi, G, Viero, G, Azzarà, C, Mantero, M, Peyvandi, F, Bassetti, M, Marchetti, G, Muscatello, A, Nobili, A, Gori, A, Bandera, A, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell’Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferarri, F, Gori., A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi., A, Ungaro, R, Ancona, G, Mussa, M, Mariani, B, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Peri, C, Saltini, P, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, Chitani, G, Bobbio, C, De Matteis, I, Bonomi, A, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D’Adda, A, Della Fiore, S, Di Pasquale, M, Mantero., M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Nobili., A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Harari, S, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D’Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalla, D, Leone, S, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Tettamanti, Mauro, Renisi, Giulia, Viero, Giulia, Azzarà, Cecilia, Mantero, Marco, Peyvandi, Flora, Bassetti, Matteo, Marchetti, Giulia, Muscatello, Antonio, Nobili, Alessandro, Gori, Andrea, Bandera, Alessandra, Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori. , Andrea, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi. , Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero. , Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili. , Alessandro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, Leone, Sara, Lombardi, A, Villa, S, Colaneri, M, Scaglione, G, Bai, F, Varisco, B, Bono, V, Vena, A, Dentone, C, Russo, C, Tettamanti, M, Renisi, G, Viero, G, Azzarà, C, Mantero, M, Peyvandi, F, Bassetti, M, Marchetti, G, Muscatello, A, Nobili, A, Gori, A, Bandera, A, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell’Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferarri, F, Gori., A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi., A, Ungaro, R, Ancona, G, Mussa, M, Mariani, B, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Peri, C, Saltini, P, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, Chitani, G, Bobbio, C, De Matteis, I, Bonomi, A, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D’Adda, A, Della Fiore, S, Di Pasquale, M, Mantero., M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Nobili., A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Harari, S, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D’Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalla, D, Leone, S, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Tettamanti, Mauro, Renisi, Giulia, Viero, Giulia, Azzarà, Cecilia, Mantero, Marco, Peyvandi, Flora, Bassetti, Matteo, Marchetti, Giulia, Muscatello, Antonio, Nobili, Alessandro, Gori, Andrea, Bandera, Alessandra, Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori. , Andrea, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi. , Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero. , Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili. , Alessandro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, and Leone, Sara

Abstract

Background: Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, and retrospective study aimed to investigate the clinical characteristics and outcomes of vaccinated vs. non-vaccinated patients, both hospitalised with SARS-CoV-2 infection in 3 major hospitals in Northern Italy. Methods: Data collection was retrospective, and paper and electronic medical records of adult patients with a diagnosed SARS-CoV-2 infection were pseudo-anonymised and analysed. Vaccinated and non-vaccinated individuals were manually paired, using a predetermined matching criterion (similar age, gender, and date of hospitalisation). Demographic, clinical, treatment, and outcome data were compared between groups differing by vaccination status using Pearson's Chi-square and Mann-Whitney tests. Moreover, multiple logistic regression analyses were performed to assess the impact of vaccination status on ICU admission or intra-hospital mortality. Results: Data from 360 patients were collected. Vaccinated patients presented with a higher prevalence of relevant comorbidities, like kidney replacement therapy or haematological malignancy, despite a milder clinical presentation at the first evaluation. Non-vaccinated patients required intensive care more often than their vaccinated counterparts (8.8% vs. 1.7%, p = 0.002). Contrariwise, no difference in intra-hospital mortality was observed between the two groups (19% vs. 20%, p = 0.853). These results were confirmed by multivariable logistic regressions, which showed that vaccination was significantly associated with decreased risk of ICU admission (aOR=0.172, 95%CI: 0.039–0.542, p = 0.007), but not of intra-hospital mortality (aOR=0.996, 95%CI: 0.582–1.703, p = 0.987). Conclusions: This study provides real-world data on vaccinated patients hospitalised wit

Published
2024

49. Large-scale cross-societal examination of real- and minimal-group biases

Author

Yang, Xin, primary, Schulz, Jonathan Friedemann, additional, Schmidt, Kathleen, additional, Kenny, Adam R, additional, Pfuhl, Gerit, additional, Gjoneska, Biljana, additional, Dalgar, Ilker, additional, Lewis, Savannah C, additional, Exner, Anna, additional, Lander, Karen, additional, Becker, Maja, additional, Du, Hongfei, additional, Johri, Akshay, additional, Selcuk, Emre, additional, Gallyamova, Albina, additional, Calluso, Cinzia, additional, Reggev, Niv, additional, Vranka, Marek Albert, additional, Acar, Oguz A., additional, Palma, Tomás A, additional, kocur, miroslaw, additional, Oliveros, Juan C., additional, Montefinese, Maria, additional, Wilton, Leigh Solano, additional, Zdybek, Przemysław, additional, Pfattheicher, Stefan, additional, Akkas, Handan, additional, Autin, Frederique, additional, Sorokowska, Agnieszka, additional, Janssen, Steve M. J., additional, March, David Scott, additional, Young, Danielle Magan, additional, Valentova, Jaroslava Varella, additional, Tasbas, Esra H. Oguz, additional, Bukun, Mehmet Fatih, additional, Giammusso, Isabella, additional, Brandt, Mark John, additional, Stewart, Suzanne, additional, Couto, Cleno, additional, Simon, Derek, additional, Cutler, Jo, additional, Prokosch, Marjorie L., additional, Sjåstad, Hallgeir, additional, Manunta, Efisio, additional, Whyte, Stephen, additional, Marsh, Abigail, additional, Papadatou-Pastou, Marietta, additional, Jaeger, Bastian, additional, Morvinski, Coby, additional, Primbs, Maximilian, additional, Akil, Atakan M., additional, Kapoor, Hansika, additional, Barzykowski, Krystian, additional, Ghai, Sakshi, additional, Moreau, David, additional, Seehuus, Martin, additional, Kowal, Marta, additional, Evans, Thomas Rhys, additional, Hill, Kimberley, additional, Calvillo, Dustin P, additional, Wiechert, Sera, additional, Afhami, Reza, additional, Hoyer, Karlijn, additional, Korbmacher, Max, additional, Elbaek, Christian T., additional, Alsuhaibani, Zainab, additional, Pronizius, Ekaterina, additional, Cui, Qianqain, additional, Cundiff, Jenny, additional, Taghipanahi, Alireza, additional, Bjornsdottir, R. Thora, additional, Baskin, Ernest, additional, Ergiyen, Tolga, additional, Metin-Orta, Irem, additional, Collins, W. Matthew, additional, Bø, Simen, additional, Marinucci, Marco, additional, Baker, Bradley James, additional, Özdoğru, Asil Ali, additional, Anne, Michele, additional, Standage, Martyn, additional, Tullett, Alexa Mary, additional, Milfont, Taciano L, additional, Flynn, Francis, additional, Zidkova, Radka, additional, Ruiz-Fernandez, Susana, additional, Sachs, Tobias, additional, Bilancini, Ennio, additional, Verheyen, Steven, additional, Massoni, Sébastien, additional, Wen, Jiahui, additional, Camargo, Andrés, additional, Wang, Yilin Andre, additional, Zhou, Steven, additional, Peetz, Hannah Katharina, additional, Grigoryev, Dmitry, additional, Ghasemi, Omid, additional, Westgate, Erin Corwin, additional, Goh, Jin X., additional, Sutherland, Clare, additional, Boucher, Leanne, additional, Grigoryan, Lusine, additional, Paltoglou, Aspa, additional, Al-Hoorie, Ali H., additional, Sacco, Donald F., additional, Thomas, Andrew G., additional, Haeffel, Gerald, additional, Davis, William E., additional, Mandalaywala, Tara M, additional, Cruz, Francisco, additional, Ross, Robert M, additional, Jiang, Xiaoming, additional, Studzinska, Anna, additional, Dumbravă, Andrei, additional, Misiak, Michał, additional, Tran, Ulrich S., additional, Felisberti, Fatima Maria, additional, Nagy, Tamas, additional, Gunaydin, Gul, additional, Buchanan, Erin Michelle, additional, Miranda, Jacob Francisco, additional, Behnke, Maciej, additional, Akin, Karen, additional, Berkessel, Jana, additional, Johnson, David Charles, additional, Morariu, Roxana E., additional, Wu, Yang, additional, Godbersen, Hendrik, additional, Edlund, John, additional, Gourdon-Kanhukamwe, Amélie, additional, Martin, Doug, additional, Salvador, Cristina, additional, Norman, Jasmine B, additional, Batres, Carlota, additional, Kutuk, Bahtim, additional, Szumowska, Ewa, additional, Storage, Daniel, additional, Bouguettaya, Ayoub, additional, Lins, Samuel, additional, Voracek, Martin, additional, Trémolière, Bastien, additional, Cyrus-Lai, Wilson, additional, Alzahawi, Shilaan, additional, Tavel, Petr, additional, Anderson, Leif Douglas, additional, Röer, Jan Philipp, additional, Malinakova, Klara, additional, KARABABA, Alper, additional, Walczak, Radoslaw B., additional, Ribeiro, Gianni, additional, Sarı, Erkin, additional, Pypno, Katarzyna, additional, Paruzel-Czachura, Mariola, additional, Travaglino, Giovanni A., additional, Neta, Maital, additional, Vaidis, David C., additional, Lu, Jackson G., additional, Tatachari, Srinivasan, additional, Camgöz, Selin Metin, additional, Lockwood, Patricia, additional, Mitkidis, Panagiotis, additional, Lin, Wenzheng, additional, Rathje, Steve, additional, van Lent, Tjits, additional, Greijdanus, Hedy, additional, Faure, Ruddy, additional, Lamm, Claus, additional, Brick, Cameron, additional, Zhao, Xian, additional, Aquino, Sibele Dias, additional, Ulloa Fulgeri, Jose Luis, additional, Walker, Bradley, additional, Malecki, W. P., additional, Lou, Nigel Mantou, additional, Pizziol, Veronica, additional, Kuzminska, Anna O., additional, Schepisi, Michael, additional, Adıgüzel, Arca, additional, Karadeniz, Gizem, additional, Yücel, Emine, additional, Isloi, Chris, additional, Chwiłkowska, Patrycja, additional, Yu, Zhaoliang, additional, Fay, Nicolas, additional, Papaioannou, Kostas, additional, Peker, Mhmet, additional, Huang, Guanxiong, additional, El-Haddad, Rita W., additional, Verschuere, Bruno, additional, Meier, Zdenek, additional, Vaughn, Leigh Ann, additional, Albayrak-Aydemir, Nihan, additional, Ciesla, Kylie L, additional, Stieger, Stefan, additional, Çoksan, Sami, additional, Bijlstra, Gijsbert, additional, Alves, Sara Gouveia, additional, Hartanto, Andree, additional, Mallik, Peter Robert, additional, Jami, Waleed, additional, Chen, Rong, additional, Fellnhofer, Katharina, additional, Marcu, Gabriela Mariana, additional, Batalha, Luisa, additional, Kocalar, Halil Emre, additional, Vieira, Luc, additional, Gleibs, Ilka Helene, additional, Sharifian, MohammadHasan, additional, Hadjisolomou, Stavros P., additional, Riva, Paolo, additional, Sirota, Miroslav, additional, Novák, Lukas, additional, Sorokowski, Piotr, additional, Li, Yansong, additional, and Dunham, Yarrow, additional

Published
2024
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50. Protective Effect of Knee Postoperative Fluid on Oxidative-Induced Damage in Human Knee Articular Chondrocytes

Author

Roberta Giordo, Smitha Tulasigeri Totiger, Gianfilippo Caggiari, Annalisa Cossu, Andrea Fabio Manunta, Anna Maria Posadino, and Gianfranco Pintus

Subjects
reactive oxygen species, osteoarthritis, chondrocytes, growth factors, post-operation knee fluid, Therapeutics. Pharmacology, RM1-950
Abstract

The oxidative-stress-elicited deterioration of chondrocyte function is the initial stage of changes leading to the disruption of cartilage homeostasis. These changes entail a series of catabolic damages mediated by proinflammatory cytokines, MMPs, and aggrecanases, which increase ROS generation. Such uncontrolled ROS production, inadequately balanced by the cellular antioxidant capacity, eventually contributes to the development and progression of chondropathies. Several pieces of evidence show that different growth factors, single or combined, as well as anti-inflammatory cytokines and chemokines, can stimulate chondrogenesis and improve cartilage repair and regeneration. In this view, hypothesizing a potential growth-factor-associated action, we investigate the possible protective effect of post-operation knee fluid from patients undergoing prosthesis replacement surgery against ROS-induced damage on normal human knee articular chondrocytes (HKACs). To this end, HKACs were pre-treated with post-operation knee fluid and then exposed to H2O2 to mimic oxidative stress. Intracellular ROS levels were measured by using the molecular probe H2DCFDA; cytosolic and mitochondrial oxidative status were assessed by using HKACs infected with lentiviral particles harboring the redox-sensing green fluorescent protein (roGFP); and cell proliferation was determined by measuring the rate of DNA synthesis with BrdU incorporation. Moreover, superoxide dismutase (SOD), catalase, and glutathione levels from the cell lysates of treated cells were also measured. Postoperative peripheral blood sera from the same patients were used as controls. Our study shows that post-operation knee fluid can counteract H2O2-elicited oxidative stress by decreasing the intracellular ROS levels, preserving the cytosolic and mitochondrial redox status, maintaining the proliferation of oxidatively stressed HKACs, and upregulating chondrocyte antioxidant defense. Overall, our results support and propose an important effect of post-operation knee fluid substances in maintaining HKAC function by mediating cell antioxidative system upregulation and protecting cells from oxidative stress.

Published
2024
Full Text
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