115 results on '"Manthey, Carl L."'
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2. IL-23 regulation of myeloid cell biology during inflammation
3. Supplementary Figure 1, Tables 1-4 from JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia
4. c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat
5. Targeting renal macrophage accumulation via c-fms kinase reduces tubular apoptosis but fails to modify progressive fibrosis in the obstructed rat kidney
6. Identification of novel short chain 4-substituted indoles as potent α vβ 3 antagonist using structure-based drug design
7. Novel potent and selective α vβ 3/α vβ 5 integrin dual antagonists with reduced binding affinity for human serum albumin
8. Chapter 10 Advances in the Discovery of Anti-Inflammatory FMS Inhibitors
9. The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis
10. A functional radioreceptor assay of alpha-V-beta-3 (α vβ 3) inhibitors in plasma: Application as an ex vivo pharmacodynamic model
11. Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors
12. Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy
13. Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors
14. Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis
15. Structure-based optimization of a potent class of arylamide FMS inhibitors
16. Design and synthesis of a pyrido[2,3- d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors
17. Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor
18. Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors
19. Discovery of novel FMS kinase inhibitors as anti-inflammatory agents
20. Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141)
21. Matrix Metalloproteinase-9 Inhibition Reduces Inflammation and Improves Motility in Murine Models of Postoperative Ileus
22. JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia
23. Pyrido[2,3-d]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors
24. Identification of Novel Short Chain 4‐Substituted Indoles as Potent ανβ3 Antagonist Using Structure‐Based Drug Design.
25. Novel Potent and Selective αvβ3/αvβ5 Integrin Dual Antagonists with Reduced Binding Affinity for Human Serum Albumin.
26. A functional radioreceptor assay of alpha-V-beta-3 (αvβ3) inhibitors in plasma: Application as an ex vivo pharmacodynamic model
27. Non-peptidic αvβ3 antagonists containing indol-1-yl propionic acids
28. Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells
29. Differential Expression and Activation of p38 Mitogen-Activated Protein Kinase α, β, γ, and δ in Inflammatory Cell Lineages
30. Polymethoxylated Flavones Derived from Citrus Suppress Tumor Necrosis Factor-α Expression by Human Monocytes
31. ACID SPHINGOMYELINASE-DERIVED CERAMIDE IS NOT REQUIRED FOR INFLAMMATORY CYTOKINE SIGNALLING IN MURINE MACROPHAGES
32. SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes
33. Molecular Cloning and Functional Characterization of a Novel CC Chemokine, Stimulated T Cell Chemotactic Protein (STCP-1) That Specifically Acts on Activated T Lymphocytes
34. Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase
35. Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis.
36. Kupffer Cells Express Type I TGF-βReceptors, Migrate to TGF-βand Participate in Streptococcal Cell Wall Induced Hepatic Granuloma Formation
37. Identification of mouse liver aldehyde dehydrogenases that catalyze the oxidation of retinaldehyde to retinoic acid
38. Novel potent and selective αvβ3/αvβ5 integrin dual antagonists with reduced binding affinity for human serum albumin
39. TGF?1 Peptide and Two Distinct TGF?1 mRNA Transcripts Are Expressed in SCW-induced Granulomas
40. In Situ Expression of Transforming Growth Factor Beta in Streptococcal Cell Wall-induced Granulomatous Inflammation and Hepatic Fibrosis
41. c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat.
42. Kupffer Cells Express Type I TGF- β Receptors, Migrate to TGF- β and Participate in Streptococcal Cell Wall Induced Hepatic Granuloma Formation.
43. Targeting renal macrophage accumulation via c-fmskinase reduces tubular apoptosis but fails to modify progressive fibrosis in the obstructed rat kidney
44. Kinetic characterization of the catalysis of “activated” cyclophosphamide (4-hydroxycyclophosphamide/aldophosphamide) oxidation to carboxyphosphamide by mouse hepatic aldehyde dehydrogenases
45. Identification of Novel Short Chain 4-Substituted Indoles as Potent ανβ3 Antagonist Using Structure-Based Drug Design.
46. Identification of Novel Short Chain 4‐Substituted Indoles as Potent ανβ3Antagonist Using Structure‐Based Drug Design.
47. Novel Potent and Selective αvβ3/αvβ5Integrin Dual Antagonists with Reduced Binding Affinity for Human Serum Albumin.
48. A functional radioreceptor assay of alpha-V-beta-3 (αvβ3) inhibitors in plasma: Application as an ex vivo pharmacodynamic model
49. Non-peptidic αvβ3 antagonists containing indol-1-yl propionic acids
50. Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis.
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