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Simple Summary Optical coherence tomography (OCT) is an established ophthalmologic diagnostic tool to visualise vital retinal structures. In glaucoma, it is used to quantify the thickness decrease in the peripapillary retinal nerve fibre layer (pRNFL) and in the macula. While glaucoma management in adults incorporates traditional clinical parameters as well as instrumental methods such as OCT, guidelines for paediatric glaucoma focus on conventional methods. Even though some reports encouraging a broader use of OCT in children are present, its diagnostic potential in this particular population has still not been sufficiently analysed. To address this, the present study compares the glaucoma discriminative ability of OCT measurements of the pRNFL and macular layers in a paediatric population. The results indicate a reduction of the pRNFL and of inner macular layer thickness in glaucoma eyes, as well as a high correlation with the presence of glaucoma. The glaucoma discriminative ability can be maximised combining either all pRNFL sectors or the thickness results of the three innermost macular layers, even though sensitivity remains moderate. In conclusion, the OCT measurements of the pRNFL and macular thickness have a strong ability to diagnose paediatric glaucoma. However, OCT should be used in addition to conventional diagnostic tools rather than as a standalone method. Abstract Paediatric glaucoma leads to a decreased thickness of the peripapillary retinal nerve fibre layer (pRNFL) and of the macula. These changes can be precisely quantified using spectral domain-optical coherence tomography (SD-OCT). Despite abundant reports in adults, studies on the diagnostic capacity of macular SD-OCT in paediatric glaucoma are rare. The aim of this study was to compare the glaucoma discriminative ability of pRNFL and macular segment thickness in paediatric glaucoma patients and healthy children. Data of 72 children aged 5–17 years (glaucoma: 19 (26.4%), healthy: 53 (73.6%)) examined with SD-OCT (SPECTRALIS®, Heidelberg Engineering) were analysed retrospectively. The thickness of pRNFL sectors and of macular segment subfields were compared between diseased and healthy participants. Areas under the receiver-operating characteristic curves (AUC), sensitivity, and specificity from logistic regression were used to evaluate the glaucoma discriminative capacity of single and combined pRNFL and macular segments’ thickness. The results revealed a reduced thickness of the pRNFL and of the three inner macular layers in glaucoma patients, which correlates highly with the presence of glaucoma. The highest glaucoma discriminative ability was observed for the combination of pRNFL sectors or inner macular segments (AUC: 0.83 and 0.85, respectively), although sensitivity remained moderate (both 63% at 95% specificity). In conclusion, while confirmation from investigations in larger cohorts is required, SD-OCT-derived pRNFL and macular thickness measurements seem highly valuable for the diagnosis of paediatric glaucoma.

Despite the increased risk of subsequent primary tumors (SPTs) external beam radiation (EBRT) may be the only therapeutic option to preserve a retinoblastoma eye. Due to their physical properties, proton beam therapy (PBT) offers the possibility to use the effectiveness of EBRT in tumor treatment and to decisively reduce the treatment‐related morbidity. We report our experiences of PBT as rescue therapy in a retrospectively studied cohort of 15 advanced retinoblastoma eyes as final option for eye‐preserving therapy. The average age at the initiation of PBT was 35 (14–97) months, mean fol-low‐up was 22 (2–46) months. Prior to PBT, all eyes were treated with systemic chemotherapy and a mean number of 7.1 additional treatments. Indication for PBT was non‐feasibility of intra‐arterial chemotherapy (IAC) in 10 eyes, tumor recurrence after IAC in another 3 eyes and diffuse infiltrating retinoblastoma in 2 eyes. Six eyes (40%) were enucleated after a mean time interval of 4.8 (1–8) months. Cataract formation was the most common complication affecting 44.4% of the preserved eyes, yet 77.8% achieved a visual acuity of >20/200. Two of the 15 children treated developed metastatic disease during follow‐up, resulting in a 13.3% metastasis rate. PBT is a useful treatment modality as a rescue therapy in retinoblastoma eyes with an eye‐preserving rate of 60%. As patients are at lifetime risk of SPTs con-sistent monitoring is mandatory. OA Förderung 2021

Mael Lever,1 Jan Darius Unterlauft,2 Christian Halfwassen,1 Nikolaos E Bechrakis,1 Anke Manthey,1 Michael RR Böhm1 1Department of Ophthalmology, University Hospital Essen, Essen, Germany; 2Department of Ophthalmology, University Hospital Leipzig, Leipzig, GermanyCorrespondence: Mael LeverDepartment of Ophthalmology, University Hospital Essen, Hufelandstr. 55, Essen 45147, GermanyTel +49 201 723 2900Fax +49 201 723 5917Email mael.lever@uk-essen.dePurpose: Diagnostic 24-hour intraocular pressure curves(IPC) are well established in the management of glaucoma. However, objective criteria for the IPC indication are lacking. The aim of this study was to evaluate the impact of individual patient characteristics and glaucoma-related parameters on therapy decisions after IPC and thus examine their relevance for glaucoma management.Patients and Methods: Retrospective analysis of adult primary open-angle glaucoma (POAG) patients who underwent an IPC (≥ 6 IOP measurements in 24 hours). The main exclusion criterion was previous IOP-lowering surgery. IPC-dependent (eg, mean and peak IOP) and IPC-independent parameters (eg, perimetry, RNFL thickness) were analyzed in relation to the therapeutic decision after IPC. Further, these parameters were compared in patient subgroups based on age, glaucoma stage, or therapy intensity.Results: A total of 101 eyes of 101 patients were included. In general, mean and peak IOP were elevated in patients with a therapeutic change after IPC. These subjects presented differences of IPC-independent parameters (eg, IOP at admission, RNFL thickness, glaucoma stage). Regression analysis results suggested a predictive role of IPC-independent parameters for IPC therapeutic decisions. In subgroups of patients of older age or advanced glaucoma, IPC-independent parameters did not correlate with therapeutic decisions after IPC.Conclusion: These results support the relevance of IPC in the therapeutic management of POAG. Moreover, the study promotes a personalized classification of patients using selected glaucoma characteristics to objectivize their individual benefit from IPC. Further prospective studies are needed to verify the utility of these parameters and IPC in the management of glaucoma.Keywords: glaucoma management, IOP phasing, diagnostic, antiglaucomatous therapy