1. Genome search in celiac disease
- Author
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S. Percopo, Alessandro Ventura, Giuseppe Iacono, Fiorella Balli, Salvatore Musumeci, Ettore Cardi, Giuliano Torre, Gino Roberto Corazza, Carlo Catassi, Wilma Mantavoni, Rosanna Gatti, Françoise Clerget-Darpoux, J.L. Serre, Roberto Tosi, Francesco Cataldo, Jean François Eliaou, Stefano De Virgiliis, Umberto Volta, F. Clot, Colette Dib, Francesco Perri, R. Lazzari, Gianluigi De Angelis, Roberto Ferrari, Marie Claude Fulchignoni-Lataud, Luigi Greco, Riccardo Troncone, Patrizia Zavattari, F. Bouguerra, Giuseppe Magazzù, Annamaria Giunta, Marie Claude Babron, Maria Teresa Bardella, Greco, L, Corazza, G, Babron, Mc, Clot, F, Fulchignonilataud, Mc, Percopo, S, Zavattari, P, Bouguerra, F, Dib, C, Tosi, R, Troncone, R, Ventura, Alessandro, Mantavoni, W, Magazzu, G, Gatti, R, Lazzari, R, Giunta, A, Perri, F, Iacono, G, Cardi, E, DE VIRGILIIS, S, Cataldo, F, DE ANGELIS, G, Musumeci, S, Clergetdarpoux, F., Greco, Luigi, Fulchignoni Lataud, Mc, Troncone, Riccardo, Ventura, A, Mantovani, W, Magazzù, G, de Virgiliis, S, De Angelis, G, Ferrari, R, Balli, F, Bardella, Mt, Volta, U, Catassi, C, Torre, G, Eliaou, Jf, Serre, Jl, and Clerget Darpoux, F.
- Subjects
Genotype ,Genetic Linkage ,Human leukocyte antigen ,Biology ,Coeliac disease ,Genetic determinism ,Genome screening ,Gene mapping ,Genetic linkage ,Genetics ,Genetic predisposition ,medicine ,Humans ,Genetics(clinical) ,Genetic Testing ,Risk factor ,Genetics (clinical) ,Genetic testing ,medicine.diagnostic_test ,Linkage ,Genome, Human ,medicine.disease ,HLA ,Celiac Disease ,Research Article - Abstract
SummaryCeliac disease (CD), a malabsorption disorder of the small intestine, results from ingestion of gluten. The HLA risk factors involved in CD are well known but do not explain the entire genetic susceptibility. To determine the localization of other genetic risk factors, a systematic screening of the genome has been undertaken. The typing information of 281 markers on 110 affected sib pairs and their parents was used to test linkage. Systematic linkage analysis was first performed on 39 pairs in which both sibs had a symptomatic form of CD. Replication of the regions of interest was then carried out on 71 pairs in which one sib had a symptomatic form and the other a silent form of CD. In addition to the HLA loci, our study suggests that a risk factor in 5qter is involved in both forms of CD (symptomatic and silent). Furthermore, a factor on 11qter possibly differentiates the two forms. In contrast, none of the regions recently published was confirmed by the present screening.
- Published
- 1998