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Despite medical advances, tuberculosis is responsible for over one billion deaths in the last 200 years. This study was carried out to determine interleukin 10 levels in serum of tuberculosis patients attending Aminu Kano Specialist Hospital, Kano (AKTH). A total of 330 subjects were enlisted for this study. The subjects were grouped into: Group A (30 control) and Group B (300 subjects). DNA sequences specific for Mycobacterium tuberculosis and rifampicin resistance were detected using Gene Xpert MTB/RIF assay. 5mls of blood were aseptically collected from subjects using standard venipuncture procedure into plain tubes for HIV and Interleukin 10 assay. TB patients co-infected with HIV were excluded from this study. The Interleukin 10 level was measured using commercial Sandwich ELISA kits. The result revealed that there was significant difference (p0.05) between the interleukin-10 levels of rifampicin resistant (11.80±3.87) and non-rifampicin resistant patients (11.65±3.55). Interleukin 10 was also found to be higher among patients aged 30-39 (12.33±3.31) and female patients (11.95±3.50) than in male patients (11.45±3.65). Furthermore, Interleukin 10 level was found to be higher in TB patients before anti TB treatment (12.54±3.82) than in patients after treatment (9.86±3.59). The findings of the study showed that interleukin 10 is a viable biomarker in the pathogenesis of TB infection and can be used as prognostic marker for management of TB patients.

Textile industry production processes generate one of the most highly polluted wastewaters in the world. Unfortunately, the field is also challenged by the availability of relatively cheap and highly effective technologies for wastewater purification. The application of natural zeolite as a depth filter offers an alternative and potential approach for textile wastewater treatment. The performance of a depth filter treatment system can be deeply affected by the column depth and the characteristics of the wastewater to be treated. Regrettably, the information on the potential of these filter materials for the purification of textile wastewater is still scarce. Therefore, this study investigated the potential applicability of natural zeolite in terms of column depth for the treatment of textile wastewater. From the analysis results, it was observed that the filtration efficiencies were relatively low (6.1 to 13.7%) for some parameters such as total dissolved solids, electrical conductivity, chemical oxygen demand, and sodium chloride when the wastewater samples were subjected to the 0.5 m column depth. Relatively high efficiency of 82 and 93.8% was observed from color and total suspended solids, respectively, when the wastewater samples were subjected to the 0.5 m column depth. Generally, the 0.75 m column depth achieved removal efficiencies ranging from 52.3% to 97.5%, whereas the 1 m column depth achieved removal efficiencies ranging from 86.9% to 99.4%. The highest removal efficiency was achieved with a combination of total suspended solids and 1 m column depth (99.4%). In summary, the treatment approach was observed to be highly effective for the removal of total suspended solids, with a 93.8% removal efficiency when the wastewater was subjected to the 0.5 m column depth, 97.5% for 0.75 m column depth, and 99.4% for 1 m column depth. Moreover, up to 218.233 mg of color per g of the filter material was captured. The results derived in this study provide useful information towards the potential applicability of natural zeolite in the textile wastewater treatment field.

New N, N′-substituted imidazolium salts (L1 and L2) and their corresponding diiodopyridinepalladium(II) complexes (C1 and C2) were successfully synthesized and characterized. Reactions of palladium iodide with the newly synthesized N, N′-substituted imidazolium iodides in pyridine afforded the corresponding new palladium-N-heterocyclic carbene pyridine complexes in high yields. The new palladium(II) complex C1 was characterized by single crystal X-ray diffraction analysis. The Pd(II) ion is bonded to the nitrogen atom of the pyridine, the carbon atom of the NHC carbene ligand and two trans iodides resulting in distorted square planar geometry. The two Pd-NHC-Py complexes C1 and C2 displayed higher catalytic activity in the carbonylative Suzuki-Miyaura coupling reactions with much lower catalyst loading as compared to the catalytic systems reported in the literature.

The catalytic activity and the recycling ability of palladium–bis(oxazoline) (Pd–BOX-M) complex supported on Merrifield’s resin have been investigated in Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions of aryl bromides and aryl chlorides. The supported palladium–bis(oxazoline) catalyst demonstrated exceptional catalytic activity and excellent recycling ability. The characterization of the recycled palladium catalyst reveals no significant change in its structure, oxidation state and the amount of loaded palladium. This confirms the excellent stability of the palladium-supported catalyst.

This work assessed the anticorrosion and antifouling properties of a novel sol-gel derived hybrid coating functionalized with 5 different organic and inorganic biocides. FTIR and NMR analysis of the newly synthesized polymeric base material confirmed the photo-induced organic polymerization of the allyl groups in the allyltrimethoxysilane precursor of the polymer and the inertness of the allyl groups in the allyl glycidyl ether precursor. The parent coating and biocide-embedded coatings were applied on mild steel sheets, cured with UV light, and subjected to thermal, morphological and electrochemical characterization. The cured coatings were thermally stable, and their hydrophobicity increased after immersion in a saline medium, owing to further polymer crosslinking. According to lab-based electrochemical and visual evaluations of the corrosion protection performance of the different formulations, the coating embedded with Irgarol and MOLY-white 101 had an improved performance, compared with the formulations with the other added biocides. Field testing results from the coated samples were consistent with the lab results; i.e., some biocides positively affected the anticorrosion and antifouling behavior of the hybrid coatings, whereas other biocides negatively affected the newly developed hybrid coating. The methodology reported here holds promise for the development of multifunctional hybrid sol-gel coatings for mild steel substrates with interesting anticorrosion and antifouling activities in saline.

Charge-tagged bis(1,2,4-triazolin-5-ylidene)palladium(II) complexes have been successfully synthesized via a postmodification strategy. Reacting PdBr2 with bromo-functionalized 1,2,4-triazolium salts A·HBr and B·HBr in the presence of silver oxide afforded the bis(carbene)palladium(II) complexes trans-[PdBr2(A)2] (1a) and trans-[PdBr2(B)2] (1b), which contain tethered bromoalkyl chains. Subsequent postcoordinative nucleophilic substitution converted the bromo into ammonium groups, producing the water-soluble complexes trans-[PdBr2(C)2]Br2 (2a) and trans-[PdBr2(D)2]Br2 (2b), while attempts to prepare ammonium-functionalized triazolium salts for direct metalation were futile. All four complexes were fully characterized by means of multinuclear NMR spectroscopy, ESI mass spectrometry, elemental analysis, and X-ray diffraction analysis. The presence of trans-anti and trans-syn rotameric complexes in solution was elucidated by 1H and 13C NMR spectroscopy and theoretical calculations. Additionally, the two char...

A palladium(II)-bis(oxazoline) complex supported on silica (Pd-BOX-Si) was prepared, characterized and applied as a catalyst in Mizoroki–Heck cross-coupling reactions. The bis(oxazoline) (BOX) ligand has a hydroxyl group that can be anchored to 4-benzyl chloride-functionalized silica gel, followed by the coordination of palladium(II) chloride. The catalytic activity and the recyclability of Pd-BOX-Si have been investigated in the production of cinnamic acid derivatives via Mizoroki–Heck coupling reactions of acrylates with aryl halides; The Pd-BOX-Si catalyst demonstrated excellent catalytic activity. Characterization of the recycled Pd-BOX-Si catalyst revealed its good stability under the reaction conditions employed.

Palladium–bis(oxazoline) complexes (Pd-BOX-A and Pd-BOX-B) were synthesized and characterized by 1H, 13C NMR, IR and elemental analysis. The molecular structures of the complexes were confirmed by single-crystal X-ray analysis. In both cases, the palladium center is coordinated by the nitrogen atoms of the two oxazoline rings and two chloride ligands in a distorted square planar geometry. Despite the fact that the bis(oxazoline) ligand is achiral, the asymmetrical substitution on the phenyl spacer and the rigid backbone of the complex Pd-BOX-A induce inherent chirality and the compound crystallizes as a racemic mixture. Both complexes were found to be highly effective catalysts for Suzuki–Miyaura, Mizoroki–Heck and Sonogashira cross-coupling reactions. They also show excellent catalytic activities toward carbonylative coupling reactions.

New cationic palladium-bis(oxazoline)-phosphine (Pd-BOX-PR3) complexes (Pd-BOX-B and Pd-BOX-C) have been synthesized and characterized using 1H, 13C and 31P NMR, FTIR spectroscopy, and electrospray ionization mass spectrometry (ESI-MS). The new complexes were used as catalysts in the alkoxycarbonylation of alkynes with various alcohols as nucleophiles. The carbonylation has produced the gem-α,β-unsaturated ester isomer (3) in high regioselectivity and excellent yields. The catalyst systems have been optimized by screening the type of palladium complexes and also by varying the reaction parameters including the reaction time, solvent, and temperature. A mechanism of the catalytic cycle based on a N-protonated palladium bis(oxazoline) phosphine active species was proposed for the alkoxycarbonylation reaction.

A highly efficient protocol for the copper and phosphine free Sonogashira cross-coupling reactions of aryl iodides with terminal alkynes under aerobic conditions has been developed. Using 1 mol % of the palladium-bis(oxazoline) complex, Pd-BOX A, in the presence of KOH, and a CH 3 CN–H 2 O solvent system allowed for the cross-coupling reactions to proceed at room temperature or 60 °C. This new catalytic system was found to be highly active for the cross-coupling reaction of aryl diiodo substrates with unactivated alkyl alkynes to produce various symmetrical dialkynes, as well as for the cross-coupling of terminal dialkynes with aryl iodides to generate symmetrical disubstituted internal alkynes.

The catalytic synthesis of aryl esters and amides has been successfully achieved in the presence of the efficient palladium–bisoxazoline supported on Merrifield's resin (Pd–BOX-M). The palladium heterogeneous catalyst was prepared and characterized using various spectroscopic techniques. A bisoxazoline ligand having a suitable functional group (BOX-OH) was first synthesized, characterized, chemically supported on Merrifield's resin, and finally coordinated to palladium(II) chloride. The catalytic activity and the recycling ability of the new palladium supported catalyst have been investigated in the alkoxycarbonylation and aminocarbonylation of various aryl iodides using different alkyl and aromatic alcohols and amines as nucleophiles. The palladium heterogeneous catalyst demonstrated excellent catalytic activity and very high recycling ability in the above two carbonylation reactions. The palladium heterogeneous catalysts showed an excellent stability under carbon monoxide and under the experimental conditions.

An efficient catalytic system based on a new palladium–bis(oxazoline) (Pd-BOX-1) complex has been developed. The complex Pd-BOX-1 adopts a legless chair-type structure where the distorted square planar [PdN2Cl2] moiety and the benzene ring spacer represent the seat and the chair back, respectively. The catalytic activity of Pd-BOX-1 has been investigated in dimethylformamide–water under aerobic and mild conditions in Suzuki–Miyaura coupling reactions of arylboronic acids with aryl iodides, aryl bromides and aryl chlorides, Mizoroki–Heck coupling reactions of aryl halides with styrene derivatives, and Sonogashira coupling reactions of aryl halides with terminal alkynes. A wide range of functional groups as substituents on the arylboronic acids and aryl halides were considered. Pd-BOX-1 demonstrates exceptional air and moisture stability. Of note, the catalyst system based on Pd-BOX-1 shows high recycling ability in Suzuki–Miyaura coupling reactions in dimethylformamide–water without any loss in catalytic activity. Copyright © 2015 John Wiley & Sons, Ltd.

New bis(oxazoline) ligands and their palladium complexes were synthesized and characterized. X-ray crystal structures of the two new complexes showed distorted square planar geometry with the palladium ion bonded to nitrogens of two bidentate heterocycles in addition to two bromides and two acetate ions for Pd-BOX-1 and Pd-BOX-2, respectively. The complexes adopt a chair structure with a rigid curvature inducing an inherent chirality. The complexes were effective catalysts for Suzuki–Miyaura, Mizoroki–Heck, and copper-free Sonogashira coupling reactions in aqueous dimethylformamide and under aerobic conditions. The reaction conditions were optimized for best solvent, base, and temperature. The substrate scope of the new catalytic system was evaluated for coupling reactions of a variety of aryl halides with aryl boronic acids, alkenes, and alkynes.

This review focuses on organometallic surfactant frameworks considering their wide applications. Organometallic surfactants have grown from being used as dewaxers in complex industrial processes to the production of nanoparticles and for use in many drug delivery applications. Their properties such as self assembly, forming supramolecular structures are outstanding, providing for their myriad industrial usage. In this review, an account of properties, preparation techniques, characterisation techniques and uses of organometallic surfactants are covered.

New palladium–bis(oxazoline) (Pd–BOX) complexes were synthesized and characterized. The X-ray crystal structures of the two complexes showed that the palladium ion is bound to the nitrogen atoms of the two heterocycles of the bidentate ligand and two chloride ions in a distorted square planar geometry. The coordination to the palladium ion allows these non C2-symmetric bis(oxazoline) ligand-based complexes to acquire a rigid backbone curvature generating an inherent chirality. The catalytic activities were evaluated in Suzuki–Miyaura, Mizoroki–Heck and Sonogashira coupling reactions. The complexes showed high catalytic activities towards numerous C–C coupling reactions with various aryl halides, aryl boronic acids, alkenes and alkynes. The reactions were optimized for the most suitable temperature, solvent, and base system.

Background: Doctors and nurses are the largest and very important human resources for health within health service organizations; therefore their performance will impact the overall organizational performance. The study was aimed to assess the predictors of job motivation among Doctors and nurses of a tertiary hospital.Methods: A descriptive cross sectional study was conducted among 334 doctors and nurses. Multi-stage sampling method was used to select study respondents and self-administered questionnaires developed based on Maslow and Herzberg theories of motivation. Linear regression analysis was performed to determine the predictors of job motivation. The level of statistical significance was set at p

A highly efficient protocol for the copper and phosphine free Sonogashira cross-coupling reactions of aryl iodides with terminal alkynes under aerobic conditions has been developed. Using 1 mol % of the palladium-bis(oxazoline) complex, Pd-BOX A, in the presence of KOH, and a CH 3 CN–H 2 O solvent system allowed for the cross-coupling reactions to proceed at room temperature or 60 °C. This new catalytic system was found to be highly active for the cross-coupling reaction of aryl diiodo substrates with unactivated alkyl alkynes to produce various symmetrical dialkynes, as well as for the cross-coupling of terminal dialkynes with aryl iodides to generate symmetrical disubstituted internal alkynes.

New N,N′-substituted imidazolium salts and their corresponding dibromidopyridine–palladium(II) complexes were successfully synthesized and characterized. Reactions of palladium bromide with the newly synthesized N,N′-substituted imidazolium bromides (2a and 2b) in pyridine afforded the corresponding new N-heterocyclic carbene pyridine palladium(II) complexes (3a and 3b) in high yields. Their single-crystal X-ray structures show a distorted square planar geometry with the carbene and pyridine ligands in trans position. Both complexes show a high catalytic activity in carbonylative Sonogashira coupling reactions of aryl iodides and aryl diiodides with arylalkynes, alkylalkynes and dialkynes.

An efficient catalytic system for the title cross coupling reactions based on a novel palladium-bis(oxazoline) complex is developed which exhibits exceptional air and moisture stability.

International audience; An efficient catalytic system based on a new palladium–bis(oxazoline) () complex has been developed. The complex adopts a legless chair-type structure where the distorted square planar [PdN2Cl2] moiety and the benzene ring spacer represent the seat and the chair back, respectively. The catalytic activity of has been investigated in dimethylformamide–water under aerobic and mild conditions in Suzuki–Miyaura coupling reactions of arylboronic acids with aryl iodides, aryl bromides and aryl chlorides, Mizoroki–Heck coupling reactions of aryl halides with styrene derivatives, and Sonogashira coupling reactions of aryl halides with terminal alkynes. A wide range of functional groups as substituents on the arylboronic acids and aryl halides were considered. demonstrates exceptional air and moisture stability. Of note, the catalyst system based on shows high recycling ability in Suzuki–Miyaura coupling reactions in dimethylformamide–water without any loss in catalytic activity. Copyright © 2015 John Wiley & Sons, Ltd